MCID: SKN020
MIFTS: 36

Skin Papilloma malady

Cancer diseases, Skin diseases categories

Summaries for Skin Papilloma

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MalaCards based summary: Skin Papilloma, also known as cutaneous papilloma, is related to papilloma and adenoma. An important gene associated with Skin Papilloma is SP8 (Sp8 transcription factor), and among its related pathways are Development A3 receptor signaling and Development A2A receptor signaling. The compounds parthenolide and n-(4-hydroxyphenyl)retinamide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lung, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Aliases & Classifications for Skin Papilloma

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Skin Papilloma, Aliases & Descriptions:

Name: Skin Papilloma 9 11 61
Cutaneous Papilloma 9 61
Papilloma of Skin 9 61
 
Skin Papilloma Nos 9
Papilloma Skin 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:3178
NCIt39 C4614

Related Diseases for Skin Papilloma

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Diseases related to Skin Papilloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma31.3LALBA, TP53
2adenoma10.2
3costello syndrome10.0
4squamous cell papilloma of skin10.0
5breast adenoma10.0
6lung adenoma10.0
7endotheliitis10.0
8lung benign neoplasm10.0CHUK, TP53
9ataxia telangiectasia9.9CHUK, TP53
10thyroid hurthle cell carcinoma9.8TP53, PRKAR1A
11burkitt's lymphoma9.6TP53, CHUK, PRKAR1A
12breast cancer9.5TP53, LALBA, CHUK, PRKAR1A

Graphical network of diseases related to Skin Papilloma:



Diseases related to skin papilloma

Symptoms for Skin Papilloma

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Drugs & Therapeutics for Skin Papilloma

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Drug clinical trials:

Search ClinicalTrials for Skin Papilloma

Search NIH Clinical Center for Skin Papilloma

Genetic Tests for Skin Papilloma

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Anatomical Context for Skin Papilloma

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MalaCards organs/tissues related to Skin Papilloma:

32
Skin, Breast, Lung, Endothelial

Animal Models for Skin Papilloma or affiliated genes

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MGI Mouse Phenotypes related to Skin Papilloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9PRKAR1A, CHUK, TP53
2MP:00053718.7CHUK, TP53, SP8
3MP:00053828.6PRKAR1A, CHUK, TP53, SP8
4MP:00053888.6SP8, TP53, CHUK, PRKAR1A
5MP:00053818.6PRKAR1A, CHUK, TP53, SP8
6MP:00053908.5PRKAR1A, CHUK, TP53, SP8
7MP:00053808.4SP8, TP53, CHUK, PRKAR1A
8MP:00053798.1TP53, LALBA, CHUK, PRKAR1A

Publications for Skin Papilloma

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Articles related to Skin Papilloma:

(show all 35)
idTitleAuthorsYear
1
Flower-deficient mice have reduced susceptibility to skin papilloma formation. (22362363)
2012
2
Photodynamic therapy using a novel photosensitizer, TONS501, is similarly effective to ALA and EC036 photodynamic therapy on DMBA-and TPA-induced mouse skin papilloma. (22464765)
2012
3
Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice. (19617203)
2011
4
Increased skin papilloma formation in mice lacking glutathione transferase GSTP. (21975931)
2011
5
Phellinus rimosus (Berk.) pilat attenuates 7,12-dimethylbenz[a] anthracene induced and croton oil promoted skin papilloma formation in mice. (22070052)
2011
6
Bilharzia of the breast masquerading as a breast skin papilloma in a pregnant woman. (22353277)
2011
7
Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. (20619141)
2010
8
Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling. (20080939)
2010
9
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. (19587094)
2009
10
Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma. (17622315)
2007
11
Congenital mucus retention cyst of penis presenting as skin papilloma. (17320684)
2007
12
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. (17909021)
2007
13
Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice. (16624193)
2006
14
Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice. (16329151)
2006
15
Treatment of skin papillomas with topical alpha-lactalbumin-oleic acid. (15215482)
2004
16
Control of intracellular movement of connexins by E-cadherin in murine skin papilloma cells. (11640887)
2001
17
Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Momordica charantia. (10958332)
2000
18
Comparative expression of novel vascular endothelial growth factor/vascular permeability factor transcripts in skin, papillomas, and carcinomas of v-Ha-ras Tg.AC transgenic mice and FVB/N mice. (9647747)
1998
19
Topical retinoic acid reduces skin papilloma formation but resistant papillomas are at high risk for malignant conversion. (9537245)
1998
20
Mathematical modeling of skin papilloma data in SENCAR mice. (9439737)
1997
21
Suppression of mouse skin papilloma by canthaxanthin and beta-carotene in vivo: possibility of the regression of tumorigenesis by carotenoids without conversion to retinoic acid. (8875557)
1996
22
Inhibition of 12-O-tetradecanoylphorbol-13-acetate promoted mouse skin papilloma by digalactosyl diacylglycerols from the fresh water cyanobacterium Phormidium tenue. (8640752)
1996
23
Effect of excess dietary retinoic acid on skin papilloma and carcinoma formation induced by a complete carcinogenesis protocol in female Sencar mice. (8180970)
1994
24
Expression of protein kinase C isoforms in skin papilloma and carcinoma of mice. (8062222)
1994
25
Mouse skin papilloma formation by chronic dermal application of 7,12-dimethylbenz[a]anthracene is not reduced by diet restriction. (8293538)
1994
26
Effects of dietary retinoic acid on skin papilloma and carcinoma formation in female SENCAR mice. (8453733)
1993
27
Dietary retinoids are essential for skin papilloma formation induced by either the two-stage or the complete tumorigenesis model in female SENCAR mice. (1451104)
1992
28
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papilloma by saponins. (1846234)
1991
29
Inhibition of 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation in mice by dehydroepiandrosterone and two synthetic analogs. (2529051)
1989
30
A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocols. (3780626)
1986
31
Dehydroepiandrosterone (DHEA) and 3 beta-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice. (6231135)
1984
32
Inhibition by quercetin of the promoting effect of teleocidin on skin papilloma formation in mice initiated with 7,12-dimethylbenz[a]anthracene. (6428958)
1984
33
Further studies of eel virus (Berlin) isolated from the blood of eels (Anguilla anguilla) with skin papilloma. (981684)
1976
34
Suspicious influence of thymectomy on skin papilloma induction. (5781976)
1969
35
Close-packed array of virus-like particles within cells of a human skin papilloma. (13121031)
1953

Variations for Skin Papilloma

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Expression for genes affiliated with Skin Papilloma

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Expression patterns in normal tissues for genes affiliated with Skin Papilloma

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Pathways for genes affiliated with Skin Papilloma

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Pathways related to Skin Papilloma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development A1 receptor signaling59
G protein signaling G Protein alpha q signaling cascades59
9.5CHUK, PRKAR1A
2
Show member pathways
Development A2B receptor action via G protein alpha s59
9.5CHUK, PRKAR1A
39.5CHUK, PRKAR1A
4
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.4CHUK, TP53
5
Show member pathways
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.4CHUK, TP53
6
Show member pathways
9.4CHUK, TP53
79.4CHUK, TP53
89.4CHUK, TP53
9
Show member pathways
9.4TP53, CHUK
10
Show member pathways
9.4TP53, CHUK
11
Show member pathways
Immune response MIF in innate immunity response59
9.4CHUK, TP53
12
Show member pathways
Signal transduction PTEN pathway59
9.4TP53, CHUK
13
Show member pathways
9.4CHUK, TP53
149.4CHUK, TP53
15
Show member pathways
9.4CHUK, TP53
16
Show member pathways
9.4CHUK, TP53
17
Show member pathways
9.4CHUK, TP53
189.3PRKAR1A, TP53
199.3TP53, PRKAR1A
20
Show member pathways
8.9PRKAR1A, CHUK, TP53
21
Show member pathways
8.9PRKAR1A, CHUK, TP53
22
Show member pathways
8.9PRKAR1A, CHUK, TP53
23
Show member pathways
8.9TP53, CHUK, PRKAR1A
24
Show member pathways
8.4TP53, CHUK, PRKAR1A, HTR1E

Compounds for genes affiliated with Skin Papilloma

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Compounds related to Skin Papilloma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1parthenolide44 310.7CHUK, TP53
2n-(4-hydroxyphenyl)retinamide449.7CHUK, TP53
3c2ceramide449.7CHUK, TP53
4bortezomib44 50 1211.6CHUK, TP53
5pdtc449.6TP53, CHUK
6geldanamycin44 50 60 1212.5TP53, CHUK
7sp 60012544 6010.5CHUK, TP53
8resveratrol44 60 25 1212.4TP53, CHUK
9egcg449.4CHUK, TP53
10camptothecin44 60 1211.1CHUK, TP53
11oligonucleotide449.1HTR1E, CHUK, TP53
12steroid448.9PRKAR1A, CHUK, LALBA
13glutamate448.6PRKAR1A, CHUK, LALBA
14arginine448.6PRKAR1A, LALBA, TP53

GO Terms for genes affiliated with Skin Papilloma

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Products for genes affiliated with Skin Papilloma

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Sources for Skin Papilloma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet