MCID: SKN022
MIFTS: 47

Skin Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Skin Squamous Cell Carcinoma

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32MalaCards
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MalaCards: Skin Squamous Cell Carcinoma, also known as squamous cell carcinoma of skin, is related to squamous cell carcinoma and papilloma. An important gene associated with Skin Squamous Cell Carcinoma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are PAK Pathway and Apoptotic cleavage of cell adhesion proteins. The compounds cycloheximide and ursolic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Skin Squamous Cell Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

skin squamous cell carcinoma 8
squamous cell carcinoma of skin 8 60
epidermoid skin carcinoma 8


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Disease Ontology8 DOID:3151
SNOMED-CT56 254651007
NCIt39 C4819

Related Diseases for Skin Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Skin Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.4EIF4E, CDH1, EGF
2papilloma30.2TP63
3melanoma30.2PARP1, EIF4E, IL10, CDH1, TP63, STAT2
4clear cell squamous cell skin carcinoma10.3
5acantholytic squamous cell skin carcinoma10.3
6palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.3
7pseudovascular skin squamous cell carcinoma10.3
8epidermodysplasia verruciformis10.3
9basal cell carcinoma10.2
10squamous cell papilloma10.1
11anal margin squamous cell carcinoma10.1
12xeroderma pigmentosum10.1
13spindle cell carcinoma10.1
14keratoacanthoma10.1
15renal cell carcinoma10.1
16skin disease10.1
17skin melanoma10.1
18skin papilloma10.1
19laryngeal benign neoplasm10.0EIF4E
20esophageal cancer10.0CDH1
21insulin resistance10.0RARRES2
22gastritis10.0TXN
23hepatitis10.0PARP1
24kidney cancer10.0CDH1
25hepatoblastoma10.0CASP3
26hepatitis b10.0TXN, SHFM1
27pancreatitis10.0IL10
28actinic keratosis10.0TP63
29adult t-cell leukemia10.0TXN
30eye disease10.0CASP3
31pertussis10.0PARP1
32meningioma10.0EGF
33fibrosarcoma10.0STAT2, TXN
34sarcoma10.0TP63, TCF19
35pemphigus vulgaris10.0CDH1
36cholangiocarcinoma10.0CDH1, EIF4E
37hepatitis c10.0IL10
38thyroid cancer10.0EGF
39acute pancreatitis10.0IL10
40cervical cancer10.0CASP3, PARP1
41ischemia10.0CASP3, PARP1
42medulloblastoma10.0CASP3, PARP1
43ataxia telangiectasia10.0PARP1, CASP3
44osteosarcoma10.0PARP1, CASP3
45asthma10.0PARP1, IL10
46myeloid leukemia10.0PARP1, STAT2, CASP3
47laryngeal squamous cell carcinoma10.0TP63, CDH1, EIF4E
48malignant mesothelioma10.0TP63, CDH1, TXN
49endometrial carcinoma10.0CDH1, EGF
50oral cancer10.0CASP3, CDH1, PARP1

Graphical network of the top 20 diseases related to Skin Squamous Cell Carcinoma:



Diseases related to skin squamous cell carcinoma

Clinical Features for Skin Squamous Cell Carcinoma

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Drugs & Therapeutics for Skin Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Skin Squamous Cell Carcinoma

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Anatomical Context for Skin Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Skin Squamous Cell Carcinoma:

32
Skin, Breast, Lymph node, Smooth muscle, Lung, Monocytes, T cells

Animal Models for Skin Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Skin Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0PARP1, CDH1, CASP3
2MP:00053799.6CEBPA, EGF, CASP3, KLF4
3MP:00053899.1KLF4, CASP3, EGF, CDH1, PARP1, CEBPA
4MP:00053819.0KLF4, CASP3, EGF, CDH1, IL10, CEBPA
5MP:00020068.9KLF4, CDH1, IL10, EIF4E, CEBPA, TP63
6MP:00053848.2KLF4, TXN, CASP3, STAT2, CDH1, IL10

Publications for Skin Squamous Cell Carcinoma

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50PubMed
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Articles related to Skin Squamous Cell Carcinoma:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Increased expression of enhancer of Zeste Homolog 2 (EZH2) differentiates squamous cell carcinoma from normal skin and actinic keratosis. (24413452)
2014
2
Low grade malignant proliferating pilar tumor arising from breast skin simulating squamous cell carcinoma, a case report. (24426769)
2013
3
Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. (23460078)
2013
4
Selective in situ protein expression profiles correlate with distinct phenotypes of basal cell carcinoma and squamous cell carcinoma of the skin. (23446646)
2013
5
Host characteristics, sun exposure, indoor tanning and risk of squamous cell carcinoma of the skin. (24408678)
2013
6
Treatment of unresectable squamous cell carcinoma of the skin with epidermal growth factor receptor antibodies--a case series. (24135559)
2013
7
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. (23188079)
2012
8
Itch and pain in nonmelanoma skin cancer: pain as an important feature of cutaneous squamous cell carcinoma. (23247491)
2012
9
Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]. (21602158)
2011
10
Association between basal, squamous cell carcinomas, dysplastic nevi and myotonic muscular dystrophy indicates an important role of RNA-binding proteins in development of human skin cancer. (19902230)
2010
11
Aberrant upregulation of MUC4 mucin expression in cutaneous condyloma acuminatum and squamous cell carcinoma suggests a potential role in the diagnosis and therapy of skin diseases. (20591909)
2010
12
Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: a spectrum of disease progression. (20231500)
2010
13
Expression, clinical and pathological significance of KIAA1173 gene in skin squamous cell carcinoma]. (20646595)
2010
14
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. (19729838)
2009
15
Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. (18963287)
2009
16
Downregulation of tazarotene induced gene-2 (TIG2) in skin squamous cell carcinoma. (18955196)
2008
17
Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin. (18770863)
2008
18
Nuclear KrA1ppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. (18376139)
2008
19
Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. (17525275)
2007
20
Significance of eIF4E expression in skin squamous cell carcinoma. (17689990)
2007
21
Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. (17283176)
2007
22
A case of epidermodysplasia verruciformis with squamous cell carcinomas on non-sun-exposed areas of skin. (17367237)
2007
23
Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's disease and squamous cell carcinoma of the skin. (16700665)
2006
24
A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. (16565508)
2006
25
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. (16683253)
2006
26
Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. (16823845)
2006
27
Invasive squamous cell carcinoma arising from verrucous carcinoma. Recognition of verrucous carcinoma of skin as an in situ carcinoma. (16935807)
2006
28
Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures. (16700662)
2006
29
Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon alpha action in skin squamous cell carcinoma cells. (12748307)
2003
30
Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (12534602)
2003
31
Pagetoid variant of actinic keratosis with or without squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget's disease. (12383215)
2002
32
Molecular carcinogenesis of squamous cell carcinomas of the skin. (12322999)
2002
33
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry. (11357224)
2001
34
PTCH mutations in squamous cell carcinoma of the skin. (11286632)
2001
35
Internalization of the E-cadherin/catenin complex and scattering of human mammary carcinoma cells MCF-7/AZ after treatment with conditioned medium from human skin squamous carcinoma cells COLO 16. (10714391)
2000
36
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. (10583054)
1999
37
Mixed Merkel cell carcinoma and squamous cell carcinoma of the skin. (9810922)
1998
38
Opposite effect of stable transfection of bioactive transforming growth factor-beta 1 (TGF beta 1) versus exogenous TGF beta 1 treatment on expression of 92-kDa type IV collagenase in mouse skin squamous cell carcinoma CH72 cells. (9210959)
1997
39
Ultrastructural localization of gap junction protein connexin 43 in normal human skin, basal cell carcinoma, and squamous cell carcinoma. (9449490)
1997
40
Increased concentrations of 3,4-didehydroretinol and retinoic acid-binding protein (CRABPII) in human squamous cell carcinoma and keratoacanthoma but not in basal cell carcinoma of the skin. (8618041)
1996
41
Proliferating cell nuclear antigen (PCNA) expression in pseudoepitheliomatous hyperplasia, keratoacanthoma and squamous cell carcinoma of the skin. (8893923)
1996
42
Induction of the 72-kD heat shock protein in human skin melanoma and squamous cell carcinoma cell lines. (8647995)
1995
43
p53 expression in Bowen's disease and in microinvasive squamous cell carcinoma of the skin. (7675772)
1995
44
Patterns of cell proliferation in actinic keratoacanthomas and squamous cell carcinomas of the skin. Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections. (8600794)
1995
45
p53 expression in pseudoepitheliomatous hyperplasia, keratoacanthoma, and squamous cell carcinoma of skin. (8168036)
1994
46
Multiple metachronous skin squamous cell carcinomas and epidermodysplasia verruciformis in the head region: a human papilloma virus-associated disease. (7848644)
1994
47
13-cis-retinoic acid and interferon alpha-2a: effective combination therapy for advanced squamous cell carcinoma of the skin. (1734084)
1992
48
Keratoacanthoma and squamous cell carcinoma of the skin: immunohistochemical localization of involucrin and keratin proteins. (2419374)
1986
49
Eosinophil infiltration in keratoacanthoma and squamous cell carcinoma of the skin. (6479904)
1984
50
Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease? (626922)
1978

Genetic Variations for Skin Squamous Cell Carcinoma

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Expression for genes affiliated with Skin Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Squamous Cell Carcinoma

Search GEO for disease gene expression data for Skin Squamous Cell Carcinoma.

Pathways for genes affiliated with Skin Squamous Cell Carcinoma

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51QIAGEN, 53Reactome, 55SinoBiological, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Skin Squamous Cell Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7PARP1
2ursolic acid4410.5PARP1
3honokiol4410.4CASP3, PARP1
4pki-1664410.4CDH1, EGF
5polyadenosine diphosphate ribose4410.4PARP1, CASP3
6d-api4410.4PARP1, CASP3
7oridonin4410.4PARP1, CASP3
8se-methylselenocysteine44 2411.3PARP1, CASP3
9deta nonoate4410.3PARP1, EIF4E
104,6-diamidino-2-phenylindole4410.3PARP1, CASP3
11beta-lapachone4410.3PARP1, CASP3
12indole-3-carbinol4410.3PARP1, CDH1, CASP3
13manumycin4410.2PARP1, EGF, CASP3
14ifn-alpha4410.2EIF4E, IL10, STAT2
15celecoxib44 59 28 49 11 2415.2CASP3, CDH1, PARP1
16rottlerin4410.1CASP3, EGF, PARP1
17sanguinarine4410.1PARP1, CASP3
18irinotecan44 49 1112.1EGF, CDH1, PARP1
19exisulind4410.1CDH1, CASP3
20dexamethasone44 49 28 1113.0TXN, CDH1, PARP1
21h2o24410.0EGF, EIF4E, PARP1
22sulforaphane4410.0PARP1, CASP3, TXN
23rotenone4410.0TXN, CASP3, PARP1
24gemcitabine44 49 1112.0CASP3, EGF, IL10, PARP1
25geldanamycin44 49 59 1113.0EGF, CDH1, PARP1
26u0126449.9EGF, CASP3
2715-deoxy-delta-12,14-prostaglandin j2449.9IL10, CASP3, TXN
28suberoylanilide hydroxamic acid449.9PARP1, CDH1, CASP3, TXN
29mg 13244 5910.9CASP3, EGF, CDH1, EIF4E, PARP1
30docetaxel44 49 59 1112.9TXN, CASP3, CDH1, PARP1
31genistein44 28 59 2 11 2414.8CASP3, STAT2, EGF, CDH1, PARP1
324-hydroxynonenal44 2410.8TXN, CASP3, IL10, PARP1
33arsenite44 2410.8PARP1, EIF4E, CASP3, TXN
34rapamycin449.8CASP3, EGF, CDH1, IL10, EIF4E
35agar449.8TXN, EGF, CDH1, EIF4E
36paclitaxel44 49 1111.8PARP1, CDH1, EGF, CASP3
37etoposide44 49 59 1112.7PARP1, EIF4E, CDH1, CASP3, TXN
38n acetylcysteine449.7TXN, CASP3, CDH1, EIF4E, PARP1
39sb 20358044 5910.6CASP3, EGF, CDH1, IL10, EIF4E, PARP1
40ly294002449.6CASP3, EGF, CDH1, IL10, EIF4E, PARP1
41actinomycin d449.6TXN, CASP3, EGF, EIF4E, PARP1
42mitomycin c449.6TXN, IL10, TP63
43pd 98,059449.6KLF4, CASP3, EGF, CDH1, EIF4E, PARP1
44doxorubicin44 49 1111.4TXN, CASP3, EGF, CDH1, PARP1, TP63
45cisplatin44 49 59 1112.3TXN, CASP3, EGF, CDH1, EIF4E, PARP1
46cysteine449.2TXN, CASP3, EGF, CDH1, EIF4E, RARRES2
47vegf449.0TXN, CASP3, EGF, CDH1, IL10, EIF4E
48retinoic acid44 249.7TP63, TXN, CASP3, STAT2, EGF, CDH1
49serine448.5TXN, CASP3, STAT2, EGF, CDH1, EIF4E

GO Terms for genes affiliated with Skin Squamous Cell Carcinoma

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16Gene Ontology
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Biological processes related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.1CDH1, EGF
2cellular response to lithium ionGO:07128510.1CEBPA, CDH1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.0CDH1, CASP3
4negative regulation of B cell proliferationGO:0308899.7IL10, CASP3
5negative regulation of transcription from RNA polymerase II promoterGO:0001229.2KLF4, TXN, PARP1, CEBPA, TP63
6positive regulation of transcription, DNA-dependentGO:0458938.8TP63, KLF4, CRLF3, EGF, TRIM16, CDH1

Molecular functions related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2TP63, TXN, CASP3, STAT2, EGF, SHFM1

Products for genes affiliated with Skin Squamous Cell Carcinoma

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Sources for Skin Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet