MCID: SKN022
MIFTS: 47

Skin Squamous Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Skin Squamous Cell Carcinoma

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32MalaCards
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MalaCards: Skin Squamous Cell Carcinoma, also known as squamous cell carcinoma of skin, is related to squamous cell carcinoma and papilloma. An important gene associated with Skin Squamous Cell Carcinoma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are PAK Pathway and Apoptotic cleavage of cell adhesion proteins. The compounds cycloheximide and ursolic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Skin Squamous Cell Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

skin squamous cell carcinoma 8
squamous cell carcinoma of skin 8 60
epidermoid skin carcinoma 8


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Disease Ontology8 DOID:3151
SNOMED-CT56 254651007
NCIt39 C4819

Related Diseases for Skin Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Skin Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.4EIF4E, CDH1, EGF
2papilloma30.2TP63
3melanoma30.2PARP1, EIF4E, IL10, CDH1, TP63, STAT2
4clear cell squamous cell skin carcinoma10.3
5acantholytic squamous cell skin carcinoma10.3
6palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.3
7pseudovascular skin squamous cell carcinoma10.3
8epidermodysplasia verruciformis10.3
9basal cell carcinoma10.2
10squamous cell papilloma10.1
11anal margin squamous cell carcinoma10.1
12xeroderma pigmentosum10.1
13spindle cell carcinoma10.1
14keratoacanthoma10.1
15renal cell carcinoma10.1
16skin disease10.1
17skin melanoma10.1
18skin papilloma10.1
19laryngeal benign neoplasm10.0EIF4E
20esophageal cancer10.0CDH1
21insulin resistance10.0RARRES2
22gastritis10.0TXN
23hepatitis10.0PARP1
24kidney cancer10.0CDH1
25hepatoblastoma10.0CASP3
26hepatitis b10.0TXN, SHFM1
27pancreatitis10.0IL10
28actinic keratosis10.0TP63
29adult t-cell leukemia10.0TXN
30eye disease10.0CASP3
31pertussis10.0PARP1
32meningioma10.0EGF
33fibrosarcoma10.0STAT2, TXN
34sarcoma10.0TP63, TCF19
35pemphigus vulgaris10.0CDH1
36cholangiocarcinoma10.0CDH1, EIF4E
37hepatitis c10.0IL10
38thyroid cancer10.0EGF
39acute pancreatitis10.0IL10
40cervical cancer10.0CASP3, PARP1
41ischemia10.0CASP3, PARP1
42medulloblastoma10.0CASP3, PARP1
43ataxia telangiectasia10.0PARP1, CASP3
44osteosarcoma10.0PARP1, CASP3
45asthma10.0PARP1, IL10
46myeloid leukemia10.0PARP1, STAT2, CASP3
47laryngeal squamous cell carcinoma10.0TP63, CDH1, EIF4E
48malignant mesothelioma10.0TP63, CDH1, TXN
49endometrial carcinoma10.0CDH1, EGF
50oral cancer10.0CASP3, CDH1, PARP1

Graphical network of the top 20 diseases related to Skin Squamous Cell Carcinoma:



Diseases related to skin squamous cell carcinoma

Clinical Features for Skin Squamous Cell Carcinoma

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Drugs & Therapeutics for Skin Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Skin Squamous Cell Carcinoma

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Anatomical Context for Skin Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Skin Squamous Cell Carcinoma:

32
Skin, Breast, Lymph node, Lung, Monocytes, T cells, Smooth muscle

Animal Models for Skin Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Skin Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0PARP1, CDH1, CASP3
2MP:00053799.6KLF4, CASP3, CEBPA, EGF
3MP:00053899.1PARP1, CDH1, EGF, CASP3, CEBPA, KLF4
4MP:00053819.0TP63, KLF4, CASP3, EGF, CDH1, IL10
5MP:00020068.9CEBPA, TP63, KLF4, CDH1, IL10, EIF4E
6MP:00053848.2KLF4, TXN, CASP3, STAT2, CDH1, IL10

Publications for Skin Squamous Cell Carcinoma

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50PubMed
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Articles related to Skin Squamous Cell Carcinoma:

(show top 50)    (show all 181)
idTitleAuthorsYear
1
Immunohistochemical analysis of TIMP-3 and MMP-9 in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma. (24011615)
2013
2
Significance of cyclooxygenase 2, EZH-2 polycomb group and p53 expression in actinic keratosis and squamous cell carcinomas of the skin. (23095338)
2013
3
Expression and function of NET-1 in human skin squamous cell carcinoma. (24196235)
2013
4
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. (22824799)
2013
5
Pronounced allelic imbalance at D9S162 in skin squamous cell carcinoma of organ transplant recipients. (22508773)
2012
6
Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck. (22513208)
2012
7
Direct skin involvement of cervical lymph node metastasis from mucosal squamous cell carcinoma of the head and neck. (23217250)
2012
8
Molecular discrimination of cutaneous squamous cell carcinoma from actinic keratosis and normal skin. (21743436)
2011
9
Vulvar skin metastasis of lung squamous cell carcinoma. (22148044)
2011
10
C/EBPI+ expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPI+ confers susceptibility to UVB-induced skin squamous cell carcinomas. (21346772)
2011
11
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin. (21569099)
2011
12
Cutaneous squamous cell carcinoma (SCC) and the DNA damage response: pATM expression patterns in pre-malignant and malignant keratinocyte skin lesions. (21747934)
2011
13
Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma. (21480386)
2011
14
Basaloid squamous cell carcinoma of the skin. (21167410)
2011
15
High-mobility group A1 (HMGA1) protein expression correlates with cisplatin-induced cell death in squamous cell carcinoma of skin. (19916743)
2010
16
Xeroderma pigmentosum: neck lymph node metastasis of a squamous cell carcinoma of the skin treated with cetuximab. (19106040)
2009
17
Proteinase-activated receptor-2 expression in basal and squamous cell carcinomas compared with normal skin. (19032384)
2009
18
Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin. (18404670)
2008
19
Polymorphisms in the DNA repair gene XRCC1 associated with basal cell carcinoma and squamous cell carcinoma of the skin in a Korean population. (17355263)
2007
20
Beta-catenin and CD44 expression in keratoacanthoma and squamous cell carcinoma of the skin. (17679465)
2007
21
The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin. (17334634)
2007
22
Expression of peripheral benzodiazepine receptor, PCNA, and caspase-3 in cells of skin melanoma and squamous cell carcinoma. (18256758)
2007
23
Activation of the extracellular signal-regulated kinases signaling pathway in squamous cell carcinoma of the skin. (20103886)
2007
24
Laryngeal squamous cell carcinoma with infradiaphragmatic presentation of skin metastases. (16487102)
2006
25
Allelic loss at Drosophila patched gene is highly prevalent in Basal and squamous cell carcinomas of the skin. (16484983)
2006
26
LRIG-1 provides a novel prognostic predictor in squamous cell carcinoma of the skin: immunohistochemical analysis for 38 cases. (15871317)
2005
27
Cyclin A and beta-catenin expression in actinic keratosis, Bowen's disease and invasive squamous cell carcinoma of the skin. (16307653)
2005
28
Pilomatrixoma of the face: a benign skin appendage mimicking squamous cell carcinoma. (15100649)
2004
29
Reduced expression and aberrant localization of p120catenin in human squamous cell carcinoma of the skin. (15033192)
2004
30
Erosive pustular dermatosis of the scalp occurring after partial thickness skin graft for squamous cell carcinoma. (15544786)
2004
31
Overexpression of serpin squamous cell carcinoma antigens in psoriatic skin. (11851888)
2002
32
Cell proliferation patterns in canine infundibular keratinizing acanthoma and well differentiated squamous cell carcinoma of the skin. (12152794)
2002
33
Humoral hypercalcemia of malignancy in squamous cell carcinoma of the skin: parathyroid hormone--related protein as a cause. (11284521)
2001
34
Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells. (11090967)
2000
35
An immunohistochemical study of E-cadherin expression in human squamous cell carcinoma of the skin: relationship between decreased expression of E-cadherin in the primary lesion and regional lymph node metastasis. (10458080)
1999
36
Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. (9579833)
1998
37
Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin. (9496908)
1998
38
Altered distribution and expression of protein tyrosine phosphatases in normal human skin as compared to squamous cell carcinomas. (9404849)
1997
39
Evaluation of laminin and cytokeratin-10 expression in squamous cell carcinoma of the skin. (9151104)
1997
40
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. (9350106)
1997
41
Changes of cytokeratin and involucrin expression in squamous cell carcinomas of the skin during progression to malignancy. (7539622)
1995
42
Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma. (7965407)
1994
43
Establishment of highly metastatic tumor clones derived from a skin squamous cell carcinoma (SqC-NH), D-1 and F-3, with distinct features of pulmonary metastases. (8319380)
1993
44
Poorly differentiated squamous cell carcinomas of the skin can express vimentin. (1372920)
1992
45
Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. (1599022)
1992
46
"Activated" keratinocyte phenotype is unifying feature in conditions which predispose to squamous cell carcinoma of the skin. (1691494)
1990
47
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. (3825538)
1986
48
Subungual keratoacanthoma: a variant of verrucous squamous cell carcinoma of the skin. (6679793)
1983
49
Metastatic potential of biologic variants of skin squamous cell carcinoma. (7130943)
1982
50
The histopathologic differentiation of keratoacanthoma and squamous cell carcinoma of the skin. (7430483)
1980

Genetic Variations for Skin Squamous Cell Carcinoma

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Expression for genes affiliated with Skin Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Squamous Cell Carcinoma

Search GEO for disease gene expression data for Skin Squamous Cell Carcinoma.

Pathways for genes affiliated with Skin Squamous Cell Carcinoma

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51QIAGEN, 53Reactome, 55SinoBiological, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Skin Squamous Cell Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7PARP1
2ursolic acid4410.5PARP1
3honokiol4410.4CASP3, PARP1
4pki-1664410.4CDH1, EGF
5polyadenosine diphosphate ribose4410.4PARP1, CASP3
6d-api4410.4PARP1, CASP3
7oridonin4410.4PARP1, CASP3
8se-methylselenocysteine44 2411.3PARP1, CASP3
9deta nonoate4410.3PARP1, EIF4E
104,6-diamidino-2-phenylindole4410.3PARP1, CASP3
11beta-lapachone4410.3PARP1, CASP3
12indole-3-carbinol4410.3PARP1, CDH1, CASP3
13manumycin4410.2PARP1, EGF, CASP3
14ifn-alpha4410.2EIF4E, IL10, STAT2
15celecoxib44 59 28 49 11 2415.2CASP3, CDH1, PARP1
16rottlerin4410.1CASP3, EGF, PARP1
17sanguinarine4410.1PARP1, CASP3
18irinotecan44 49 1112.1EGF, CDH1, PARP1
19exisulind4410.1CDH1, CASP3
20dexamethasone44 49 28 1113.0TXN, CDH1, PARP1
21h2o24410.0EGF, EIF4E, PARP1
22sulforaphane4410.0PARP1, CASP3, TXN
23rotenone4410.0TXN, CASP3, PARP1
24gemcitabine44 49 1112.0CASP3, EGF, IL10, PARP1
25geldanamycin44 49 59 1113.0EGF, CDH1, PARP1
26u0126449.9EGF, CASP3
2715-deoxy-delta-12,14-prostaglandin j2449.9IL10, CASP3, TXN
28suberoylanilide hydroxamic acid449.9PARP1, CDH1, CASP3, TXN
29mg 13244 5910.9CASP3, EGF, CDH1, EIF4E, PARP1
30docetaxel44 49 59 1112.9TXN, CASP3, CDH1, PARP1
31genistein44 28 59 2 11 2414.8CASP3, STAT2, EGF, CDH1, PARP1
324-hydroxynonenal44 2410.8TXN, CASP3, IL10, PARP1
33arsenite44 2410.8PARP1, EIF4E, CASP3, TXN
34rapamycin449.8CASP3, EGF, CDH1, IL10, EIF4E
35agar449.8TXN, EGF, CDH1, EIF4E
36paclitaxel44 49 1111.8PARP1, CDH1, EGF, CASP3
37etoposide44 49 59 1112.7PARP1, EIF4E, CDH1, CASP3, TXN
38n acetylcysteine449.7TXN, CASP3, CDH1, EIF4E, PARP1
39sb 20358044 5910.6CASP3, EGF, CDH1, IL10, EIF4E, PARP1
40ly294002449.6CASP3, EGF, CDH1, IL10, EIF4E, PARP1
41actinomycin d449.6TXN, CASP3, EGF, EIF4E, PARP1
42mitomycin c449.6TXN, IL10, TP63
43pd 98,059449.6KLF4, CASP3, EGF, CDH1, EIF4E, PARP1
44doxorubicin44 49 1111.4TXN, CASP3, EGF, CDH1, PARP1, TP63
45cisplatin44 49 59 1112.3TXN, CASP3, EGF, CDH1, EIF4E, PARP1
46cysteine449.2TXN, CASP3, EGF, CDH1, EIF4E, RARRES2
47vegf449.0TXN, CASP3, EGF, CDH1, IL10, EIF4E
48retinoic acid44 249.7TP63, TXN, CASP3, STAT2, EGF, CDH1
49serine448.5TXN, CASP3, STAT2, EGF, CDH1, EIF4E

GO Terms for genes affiliated with Skin Squamous Cell Carcinoma

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16Gene Ontology
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Biological processes related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.1CDH1, EGF
2cellular response to lithium ionGO:07128510.1CEBPA, CDH1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.0CDH1, CASP3
4negative regulation of B cell proliferationGO:0308899.7IL10, CASP3
5negative regulation of transcription from RNA polymerase II promoterGO:0001229.2KLF4, TXN, PARP1, CEBPA, TP63
6positive regulation of transcription, DNA-dependentGO:0458938.8TP63, KLF4, CRLF3, EGF, TRIM16, CDH1

Molecular functions related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2TP63, TXN, CASP3, STAT2, EGF, SHFM1

Products for genes affiliated with Skin Squamous Cell Carcinoma

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Sources for Skin Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet