MCID: SKN022
MIFTS: 49

Skin Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Skin Squamous Cell Carcinoma

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33MalaCards
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MalaCards: Skin Squamous Cell Carcinoma, also known as squamous cell carcinoma of skin, is related to melanoma and clear cell squamous cell skin carcinoma. An important gene associated with Skin Squamous Cell Carcinoma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and TP53 network. The compounds manumycin and z-vad-fmk have been mentioned in the context of this disorder. Affiliated tissues include skin and monocytes, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Skin Squamous Cell Carcinoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

skin squamous cell carcinoma 8
squamous cell carcinoma of skin 8 62
epidermoid skin carcinoma 8


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Disease Ontology8 DOID:3151
SNOMED-CT58 254651007
NCIt40 C4819

Related Diseases for Skin Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Skin Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma29.8STAT2, IL10, TXN, TP63, TP53, PARP1
2clear cell squamous cell skin carcinoma10.4
3acantholytic squamous cell skin carcinoma10.4
4palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.4
5pseudovascular skin squamous cell carcinoma10.3
6epidermodysplasia verruciformis10.3
7basal cell carcinoma10.2
8spindle cell carcinoma10.2
9anal margin squamous cell carcinoma10.2
10xeroderma pigmentosum10.2
11keratoacanthoma10.2
12papilloma10.2
13neuroepithelioma10.1CASP3, NET1
14myeloid leukemia10.0PARP1, STAT2, CASP3
15bronchiolo-alveolar adenocarcinoma10.0CDH1, EIF4E
16esophageal cancer10.0CDH1, TP53
17oral lichen planus10.0CASP3, TP63
18precursor t-cell acute lymphoblastic leukemia10.0CASP3, PARP1, TXN
19nasopharynx carcinoma10.0CDH1, TP53
20actinic keratosis10.0TP63, TP53
21gastric adenocarcinoma10.0CASP3, KLF4, CDH1
22tongue squamous cell carcinoma10.0CDH1, EGF, EIF4E
23stomach cancer10.0CDH1, TP53
24ataxia telangiectasia10.0CASP3, TP53, PARP1
25breast cancer, invasive ductal10.0CDH1, TP53
26lung cancer10.0PARP1, CDH1, TP53
27familial adenomatous polyposis10.0TP53, KLF4, CDH1
28bladder transitional cell carcinoma10.0CDH1, TP53, CASP3
29cholangiocarcinoma10.0CDH1, EIF4E, TP53
30medulloblastoma10.0TP53, PARP1, CASP3
31cervical squamous cell carcinoma10.0TP63, EGF
32ductal carcinoma in situ10.0TP53, CDH1
33relapsing-remitting multiple sclerosis10.0IL10, IFNA1
34malignant mesothelioma10.0TXN, TP63, CDH1
35pancreatic cancer10.0CASP3, CDH1, EGF
36b-cell lymphomas10.0TXN, PARP1, CASP3, TP53
37vascular disease10.0CASP3, IL10, TXN, TP53
38brain cancer10.0CASP3, EGF, TP53, EIF4E
39tubular adenocarcinoma10.0TP63, CDH1
40burkitt's lymphoma10.0CASP3, IFNA1, PARP1
41malignant glioma10.0TP53, EGF, CASP3, PARP1
42hepatitis c10.0IL10, IFNA1, TXN
43oral cancer10.0CDH1, TP53, PARP1, CASP3
44transitional cell carcinoma10.0TP53, CDH1, TP63
45thyroid cancer, anaplastic10.0CASP3, TP53, EGF, CDH1
46colon adenocarcinoma10.0EIF4E, CASP3, PARP1, CDH1, EGF
47kidney cancer10.0TP53, CDH1, IFNA1
48laryngeal squamous cell carcinoma10.0TP63, TP53, CDH1, EIF4E
49retinoblastoma10.0PARP1, CEBPA, CASP3, EGF, TP53
50glioblastoma multiforme9.9TP53, EIF4E, PARP1, CASP3, EGF

Graphical network of the top 20 diseases related to Skin Squamous Cell Carcinoma:



Diseases related to skin squamous cell carcinoma

Symptoms for Skin Squamous Cell Carcinoma

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Drugs & Therapeutics for Skin Squamous Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Skin Squamous Cell Carcinoma

Search NIH Clinical Center for Skin Squamous Cell Carcinoma

Genetic Tests for Skin Squamous Cell Carcinoma

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Anatomical Context for Skin Squamous Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Skin Squamous Cell Carcinoma:

33
Skin, Monocytes

Animal Models for Skin Squamous Cell Carcinoma or affiliated genes

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37MGI
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Publications for Skin Squamous Cell Carcinoma

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52PubMed
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Articles related to Skin Squamous Cell Carcinoma:

(show all 36)
idTitleAuthorsYear
1
HPV type 16-induced skin squamous cell carcinoma located on the groin of immunocompetent patients. (24116660)
2013
2
The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice. (23428654)
2013
3
Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. (23460078)
2013
4
Expression and function of NET-1 in human skin squamous cell carcinoma. (24196235)
2013
5
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. (22824799)
2013
6
Pronounced allelic imbalance at D9S162 in skin squamous cell carcinoma of organ transplant recipients. (22508773)
2012
7
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. (23188079)
2012
8
Upregulation of TCTP expression in human skin squamous cell carcinoma increases tumor cell viability through anti-apoptotic action of the protein. (22969908)
2012
9
Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo. (21493306)
2011
10
C/EBPI+ expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPI+ confers susceptibility to UVB-induced skin squamous cell carcinomas. (21346772)
2011
11
The incidence of skin squamous cell carcinoma in Osijek-Baranja County--an epidemiological study. (22220409)
2011
12
Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma. (21480386)
2011
13
Association of the DSS1 c.143G>A polymorphism with skin squamous cell carcinoma. (20220765)
2010
14
Immune phenotype of peripheral blood cells and skin squamous cell carcinoma in organ transplant recipients. (20441422)
2010
15
Expression, clinical and pathological significance of KIAA1173 gene in skin squamous cell carcinoma]. (20646595)
2010
16
Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy. (19077103)
2009
17
The preventive effect of calcitriol on skin squamous cell carcinoma may be due to its effect on prostaglandin E2 metabolism and biologic activity. (20021988)
2009
18
Functions of NET-1 gene in skin squamous cell carcinoma cell line (A431): a siRNA study]. (20078975)
2009
19
Desipramine inhibits the growth of a mouse skin squamous cell carcinoma cell line and affects glucocorticoid receptor-mediated transcription. (19575421)
2009
20
Thioredoxin upregulation by 5-aminolaevulinic acid-based photodynamic therapy in human skin squamous cell carcinoma cell line. (18477133)
2008
21
Downregulation of tazarotene induced gene-2 (TIG2) in skin squamous cell carcinoma. (18955196)
2008
22
Nuclear KrA1ppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. (18376139)
2008
23
Significance of eIF4E expression in skin squamous cell carcinoma. (17689990)
2007
24
Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma. (17513803)
2007
25
Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon alpha action in skin squamous cell carcinoma cells. (12748307)
2003
26
Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. (12535204)
2003
27
Opposite effect of stable transfection of bioactive transforming growth factor-beta 1 (TGF beta 1) versus exogenous TGF beta 1 treatment on expression of 92-kDa type IV collagenase in mouse skin squamous cell carcinoma CH72 cells. (9210959)
1997
28
Multiple metachronous skin squamous cell carcinomas and epidermodysplasia verruciformis in the head region: a human papilloma virus-associated disease. (7848644)
1994
29
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. (7689080)
1993
30
Establishment of highly metastatic tumor clones derived from a skin squamous cell carcinoma (SqC-NH), D-1 and F-3, with distinct features of pulmonary metastases. (8319380)
1993
31
Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma. (1878344)
1991
32
Analysis of cellular DNA content using flow cytometry in skin squamous cell carcinoma and its relationship to clinical behaviors. (1664278)
1991
33
Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from a xeroderma pigmentosum patient. (3164238)
1988
34
Monocyte Fc-IgG receptors expression and soluble suppressor factor in skin squamous cell carcinoma. (6198840)
1983
35
Metastatic potential of biologic variants of skin squamous cell carcinoma. (7130943)
1982
36
Establishment of a cell line of human skin squamous cell carcinoma in vitro. (7284243)
1981

Variations for Skin Squamous Cell Carcinoma

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Expression for genes affiliated with Skin Squamous Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Squamous Cell Carcinoma

Search GEO for disease gene expression data for Skin Squamous Cell Carcinoma.

Pathways for genes affiliated with Skin Squamous Cell Carcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 51PharmGKB, 54R&D Systems, 53QIAGEN, 57SinoBiological, 60Thomson Reuters, 5Cell Signaling Technology, 12EMD Millipore
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Pathways related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8EIF4E, CASP3, CD151
2
Show member pathways
9.8TP63, TP53
3
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.6STAT2, EGF, TP53
49.6CASP3, EIF4E, TP53
5
Show member pathways
9.6TP53, CASP3, EIF4E
6
Show member pathways
9.6CASP3, PARP1, TP53
7
Show member pathways
9.6EGF, CASP3, TP53
89.5CDH1, CASP3, TP53
9
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.5TP53, TP63, CASP3
10
Show member pathways
Type III interferon signaling38
9.4STAT2, IFNA1, IL10
11
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.3TP53, CDH1, SHFM1, CASP3
12
Show member pathways
9.3EGF, NET1, CASP3
139.2CASP3, EGF, TP53, CDH1
149.2EGF, CASP3, CDH1, TP53
159.1CASP3, PARP1, TXN
169.1TXN, CEBPA, IL10
17
Show member pathways
9.1CASP3, TP53, STAT2, IFNA1
189.1TP53, STAT2, IFNA1, EGF
199.1EIF4E, IFNA1, TP53, EGF
209.0KLF4, CDH1, TP53, PARP1
21
Show member pathways
Signal transduction PTEN pathway60
9.0TP53, CEBPA, CASP3, CDH1, EGF
229.0CDH1, EGF, CEBPA, TP53, CASP3
23
Show member pathways
8.9TP53, CASP3, CDH1, NET1
248.9STAT2, IFNA1, EIF4E, NET1
25
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8CASP3, IL10, IFNA1, STAT2, TP53
26
Show member pathways
8.7CASP3, EIF4E, EGF, NET1, TP53
27
Show member pathways
8.6STAT2, CEBPA, TP53, IL10, CASP3, EIF4E
28
Show member pathways
8.5CEBPA, IFNA1, EGF, CASP3, IL10, TP53
29
Show member pathways
8.1IL10, STAT2, TP53, CASP3, CDH1, EGF
30
Show member pathways
7.6TP53, IL10, IFNA1, STAT2, NET1, CDH1

Compounds for genes affiliated with Skin Squamous Cell Carcinoma

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45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1manumycin459.9EGF, PARP1, CASP3
2z-vad-fmk45 6110.9CASP3, PARP1, TP53
3p113459.9IFNA1, STAT2
4sulindac sulfide459.8EGF, CASP3, TP53
5indole-3-carbinol459.7PARP1, TP53, CASP3, CDH1
6cd 437459.6PARP1, TP53, CASP3
7temozolomide45 1110.6IFNA1, PARP1, TP53
8triptolide459.6TP53, PARP1, CASP3
9geldanamycin45 51 61 1112.6PARP1, CDH1, EGF, TP53
10ifn-alpha459.6EIF4E, IL10, STAT2, IFNA1
11noxa459.6CASP3, TP63, TP53
12bcnu459.5PARP1, TP53, IFNA1
13gemcitabine45 51 1111.4EGF, TP53, PARP1, IL10, CASP3
14egcg459.4TP53, EGF, CDH1, CASP3, PARP1
15paclitaxel45 51 1111.3CDH1, CASP3, PARP1, TP53, EGF
16thymidylate459.2IL10, IFNA1, TP53, CDH1
17camptothecin45 61 1111.2PARP1, TP53, CASP3, IFNA1
184-hydroxynonenal45 2410.2TXN, CASP3, PARP1, IL10
19mg 13245 6110.2EGF, CDH1, CASP3, PARP1, TP53, EIF4E
20irinotecan45 51 1111.1TP53, PARP1, EGF, IFNA1, CDH1
215fluorouracil459.1CDH1, EGF, CASP3, IFNA1, TP53
22genistein45 29 61 3 24 1114.0CASP3, STAT2, PARP1, EGF, CDH1
23butyrate459.0TP53, CASP3, KLF4, EGF, CDH1
242-chlorodeoxyadenosine459.0PARP1, TP53, IFNA1
25pd 98,059459.0PARP1, CDH1, CASP3, KLF4, EGF, EIF4E
26resveratrol45 61 24 1112.0PARP1, CASP3, TP53, TXN
27mitomycin c458.9IL10, TP53, TP63, TXN
28rapamycin458.9IFNA1, CDH1, CASP3, EIF4E, IL10, EGF
29suberoylanilide hydroxamic acid458.9TXN, TP53, PARP1, CASP3, CDH1
30sb 20358045 619.9EGF, CDH1, CASP3, IL10, PARP1, TP53
31ly294002458.9EIF4E, IL10, PARP1, TP53, CASP3, CDH1
32hydroxyurea45 51 1110.8TXN, TP53, IFNA1, IL10
33n acetylcysteine458.6TXN, EIF4E, CDH1, CASP3, PARP1, TP53
34adriamycin458.6CDH1, CASP3, TP53, TXN, IFNA1
35h2o2458.5PARP1, TXN, CASP3, EGF, EIF4E, TP53
36thymidine45 249.5KLF4, IFNA1, EGF, IL10, TP63, TP53
37arsenite45 249.4CASP3, IFNA1, TXN, EIF4E, PARP1, TP53
38docetaxel45 51 61 1111.3TXN, PARP1, IFNA1, CDH1, CASP3, TP53
39retinoid458.3CDH1, RARRES2, IFNA1, TXN, TP53
40estrogen458.2TP53, EGF, TXN, CEBPA, CDH1, EIF4E
41actinomycin d458.1TP53, CASP3, EIF4E, TXN, IFNA1, PARP1
42dexamethasone45 51 29 1111.1EGF, PARP1, CEBPA, CDH1, IL10, TXN
43etoposide45 51 61 1111.1CDH1, EIF4E, CASP3, IFNA1, PARP1, TP53
44cysteine458.0RARRES2, CASP3, CDH1, CD151, EIF4E, PARP1
45cycloheximide457.8CASP3, IFNA1, EIF4E, PARP1, EGF, TXN
46doxorubicin45 51 119.7TP63, PARP1, IFNA1, CASP3, CDH1, TP53
47cisplatin45 51 61 1110.5EIF4E, TXN, TP63, TP53, PARP1, IFNA1
48serine457.4STAT2, EIF4E, RARRES2, CASP3, IFNA1, TXN
49vegf457.2EIF4E, CASP3, IL10, IFNA1, TP53, TP63
50retinoic acid45 247.6EGF, CDH1, EIF4E, RARRES2, CASP3, IFNA1

GO Terms for genes affiliated with Skin Squamous Cell Carcinoma

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16Gene Ontology
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Cellular components related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.2TP63, TP53, KLF4
2nucleoplasmGO:0056548.1TXN, TP63, TP53, PARP1, STAT2, CASP3
3cytosolGO:0058297.1TP53, TP63, NET1, STAT2, CASP3, EIF4E

Biological processes related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:03022510.2PARP1, CEBPA
2regulation of protein localization to cell surfaceGO:200000810.1EGF, CDH1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.1CDH1, CASP3
4negative regulation of B cell proliferationGO:03088910.1CASP3, IL10
5cellular response to lithium ionGO:07128510.1CDH1, CEBPA
6mitotic G1 DNA damage checkpointGO:03157110.0TP63, TP53
7DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.0TP63, TP53
8response to X-rayGO:0101659.9TP63, TP53
9neuron apoptotic processGO:0514029.8CASP3, TP53, TP63
10release of cytochrome c from mitochondriaGO:0018369.7CASP3, TP53
11cellular response to ionizing radiationGO:0714799.5NET1, TP53
12cell agingGO:0075699.5TP53, TP63
13positive regulation of DNA bindingGO:0433889.4EGF, TXN
14negative regulation of apoptotic processGO:0430669.2TP63, TP53, IL10, CASP3
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.7TP63, TP53, PARP1, CEBPA, IL10, KLF4
16positive regulation of transcription, DNA-templatedGO:0458938.6EGF, CDH1, KLF4, IL10, TP53, TP63
17negative regulation of transcription from RNA polymerase II promoterGO:0001228.2TXN, TP63, TP53, PARP1, CEBPA, KLF4

Molecular functions related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.1TP53, TP63, KLF4
2transcription regulatory region DNA bindingGO:0442129.0KLF4, CEBPA, TP53, TP63
3identical protein bindingGO:0428029.0STAT2, TP53, TP63, PARP1
4sequence-specific DNA binding transcription factor activityGO:0037008.8STAT2, CEBPA, KLF4, TP53, TP63
5protein bindingGO:0055155.8STAT2, PARP1, CASP3, RARRES2, KLF4, EIF4E

Products for genes affiliated with Skin Squamous Cell Carcinoma

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Sources for Skin Squamous Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet