MCID: SKN022
MIFTS: 42

Skin Squamous Cell Carcinoma malady

Skin, Cancer categories

Summaries for Skin Squamous Cell Carcinoma

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33MalaCards
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MalaCards: Skin Squamous Cell Carcinoma, also known as squamous cell carcinoma of skin, is related to squamous cell carcinoma and clear cell squamous cell skin carcinoma. An important gene associated with Skin Squamous Cell Carcinoma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are PAK Pathway and Apoptotic cleavage of cell adhesion proteins. The compounds cycloheximide and ursolic acid have been mentioned in the context of this disorder. Affiliated tissues include lymph node, smooth muscle and lung, and related mouse phenotypes are integument and endocrine/exocrine gland.

Aliases & Classifications for Skin Squamous Cell Carcinoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Aliases & Descriptions:

skin squamous cell carcinoma 8
squamous cell carcinoma of skin 8 61
epidermoid skin carcinoma 8


External Ids:

Disease Ontology8 DOID:3151
SNOMED-CT57 254651007
NCIt40 C4819

Related Diseases for Skin Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Skin Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.4EIF4E, CDH1, EGF
2clear cell squamous cell skin carcinoma10.4
3acantholytic squamous cell skin carcinoma10.4
4palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.4
5pseudovascular skin squamous cell carcinoma10.3
6epidermodysplasia verruciformis10.3
7anal squamous cell carcinoma10.3
8basal cell carcinoma10.2
9squamous cell papilloma10.2
10anal margin squamous cell carcinoma10.2
11xeroderma pigmentosum10.2
12spindle cell carcinoma10.2
13laryngeal carcinoma10.0EIF4E
14esophageal cancer10.0CDH1
15insulin resistance10.0RARRES2
16gastritis10.0TXN
17skin cancer10.0CASP3
18papilloma10.0TP63
19hepatitis10.0PARP1
20kidney cancer10.0CDH1
21hepatoblastoma10.0CASP3
22hepatitis b10.0SHFM1, TXN
23pancreatitis10.0IL10
24actinic keratosis10.0TP63
25adult t-cell leukemia10.0TXN
26eye disease10.0CASP3
27pertussis10.0PARP1
28meningioma10.0EGF
29fibrosarcoma10.0STAT2, TXN
30sarcoma10.0TCF19, TP63
31pemphigus vulgaris10.0CDH1
32cholangiocarcinoma10.0EIF4E, CDH1
33hepatitis c10.0IL10
34thyroid cancer10.0EGF
35acute pancreatitis10.0IL10
36cervical cancer10.0PARP1, CASP3
37ischemia10.0PARP1, CASP3
38medulloblastoma10.0CASP3, PARP1
39ataxia telangiectasia10.0PARP1, CASP3
40osteosarcoma10.0PARP1, CASP3
41asthma10.0IL10, PARP1
42myeloid leukemia10.0CASP3, STAT2, PARP1
43laryngeal squamous cell carcinoma10.0CDH1, EIF4E, TP63
44malignant mesothelioma10.0TP63, CDH1, TXN
45endometrial carcinoma10.0CDH1, EGF
46oral cancer10.0PARP1, CDH1, CASP3
47psoriasis10.0TCF19, IL10, EGF
48myeloma10.0CASP3, PARP1
49vascular disease10.0TXN, CASP3, IL10
50thyroid cancer, anaplastic10.0CASP3, EGF, CDH1

Graphical network of the top 20 diseases related to Skin Squamous Cell Carcinoma:



Diseases related to skin squamous cell carcinoma

Clinical Features for Skin Squamous Cell Carcinoma

Drugs & Therapeutics for Skin Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Skin Squamous Cell Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Skin Squamous Cell Carcinoma

Search CenterWatch for Skin Squamous Cell Carcinoma

Genetic Tests for Skin Squamous Cell Carcinoma

Anatomical Context for Skin Squamous Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Skin Squamous Cell Carcinoma:

33
Lymph node, Smooth muscle, Lung, Breast, Skin, Monocytes, T cells

Animal Models for Skin Squamous Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Skin Squamous Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0PARP1, CDH1, CASP3
2MP:00053799.6CEBPA, EGF, CASP3, KLF4
3MP:00053899.1KLF4, CASP3, EGF, CDH1, PARP1, CEBPA
4MP:00053819.0KLF4, CASP3, EGF, CDH1, IL10, CEBPA
5MP:00020068.9KLF4, CDH1, IL10, EIF4E, CEBPA, TP63
6MP:00053848.2KLF4, TXN, CASP3, STAT2, CDH1, IL10

Publications for Skin Squamous Cell Carcinoma

Sources:
51PubMed
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Articles related to Skin Squamous Cell Carcinoma:

(show top 50)    (show all 182)
idTitleAuthorsYear
1
Expression of nuclear survivin in normal skin and squamous cell carcinoma: a possible role in tumour invasion. (24196791)
2014
2
HPV type 16-induced skin squamous cell carcinoma located on the groin of immunocompetent patients. (24116660)
2013
3
Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies. (24191270)
2013
4
IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study. (23549465)
2013
5
The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas. (22751111)
2013
6
Molecular discrimination of cutaneous squamous cell carcinoma from actinic keratosis and normal skin. (21743436)
2011
7
Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo. (21493306)
2011
8
The incidence of skin squamous cell carcinoma in Osijek-Baranja County--an epidemiological study. (22220409)
2011
9
Association of the DSS1 c.143G>A polymorphism with skin squamous cell carcinoma. (20220765)
2010
10
High-mobility group A1 (HMGA1) protein expression correlates with cisplatin-induced cell death in squamous cell carcinoma of skin. (19916743)
2010
11
Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. (20028750)
2010
12
Differential expression of ezrin in epithelial skin tumors: cytoplasmic ezrin immunoreactivity in squamous cell carcinoma. (20465611)
2010
13
Keratoacanthoma-type squamous cell carcinoma developing in a skin graft donor site after tumor extirpation at a distant site. (20397130)
2010
14
Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy. (19077103)
2009
15
The preventive effect of calcitriol on skin squamous cell carcinoma may be due to its effect on prostaglandin E2 metabolism and biologic activity. (20021988)
2009
16
Functions of NET-1 gene in skin squamous cell carcinoma cell line (A431): a siRNA study]. (20078975)
2009
17
Predictive and pharmacodynamic biomarker studies in tumor and skin tissue samples of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with erlotinib. (17538163)
2007
18
The kinetics of skin cancer: progression of actinic keratosis to squamous cell carcinoma. (17760601)
2007
19
Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma. (17513803)
2007
20
Laryngeal squamous cell carcinoma with infradiaphragmatic presentation of skin metastases. (16487102)
2006
21
Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. (16452166)
2006
22
Immunohistochemical analysis of EGFR and HER-2 in patients with metastatic squamous cell carcinoma of the skin. (15865067)
2005
23
Acute hypercalcaemic crisis in the course of PTH-rP producing squamous cell carcinoma of the skin--a case report]. (16521424)
2005
24
Pilomatrixoma of the face: a benign skin appendage mimicking squamous cell carcinoma. (15100649)
2004
25
Actinic keratosis: the key event in the evolution from photoaged skin to squamous cell carcinoma. Therapy based on pathogenetic and clinical aspects. (14976383)
2004
26
Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. (15491425)
2004
27
Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin. (12635142)
2003
28
Analysis of promoter hypermethylation of death-associated protein kinase and p16 tumor suppressor genes in actinic keratoses and squamous cell carcinomas of the skin. (12861061)
2003
29
Grouped skin metastases from laryngeal squamous cell carcinoma and overview of similar cases. (14996400)
2003
30
Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin. (12752119)
2003
31
Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16(INK4a) tumor suppressor. (11804749)
2002
32
Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin. (12429789)
2002
33
Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma. (11109167)
2000
34
A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin. (11091718)
1999
35
Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin. (10215192)
1999
36
Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin. (9579833)
1998
37
Desmoglein in multiple self-healing squamous epithelioma of Ferguson-Smith--comparison of staining patterns with actinic keratoacanthoma and squamous cell carcinoma of the skin. (9705163)
1998
38
Altered distribution and expression of protein tyrosine phosphatases in normal human skin as compared to squamous cell carcinomas. (9404849)
1997
39
Evaluation of laminin and cytokeratin-10 expression in squamous cell carcinoma of the skin. (9151104)
1997
40
Mutations of the INK4a locus in squamous cell carcinomas of human skin. (9125147)
1997
41
The expression of c-erbB-1 and c-erbB-2 oncogenes in basal cell carcinoma and squamous cell carcinoma of skin. (9387420)
1996
42
Demonstration of skin-derived antileukoproteinase (SKALP) and its target enzyme human leukocyte elastase in squamous cell carcinoma. (7965407)
1994
43
Proliferating cell nuclear antigen immunostaining in keratoacanthoma and squamous cell carcinoma of the skin. (7617390)
1994
44
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. (7689080)
1993
45
Poorly differentiated squamous cell carcinomas of the skin can express vimentin. (1372920)
1992
46
Analysis of cellular DNA content using flow cytometry in skin squamous cell carcinoma and its relationship to clinical behaviors. (1664278)
1991
47
Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from a xeroderma pigmentosum patient. (3164238)
1988
48
Squamous cell carcinoma of the skin in black patients with discoid lupus erythematosus. (3572918)
1987
49
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. (3825538)
1986
50
Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenocanthoma of sweat gland of Lever) of the vulva: a clinical and ultrastructural study. (709534)
1978

Genetic Variations for Skin Squamous Cell Carcinoma

Expression for genes affiliated with Skin Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Squamous Cell Carcinoma

Search GEO for disease gene expression data for Skin Squamous Cell Carcinoma.

Pathways for genes affiliated with Skin Squamous Cell Carcinoma

Sources:
52QIAGEN, 54Reactome, 56SinoBiological, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database
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Compounds for genes affiliated with Skin Squamous Cell Carcinoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7PARP1
2ursolic acid4510.5PARP1
3honokiol4510.4CASP3, PARP1
4pki-1664510.4CDH1, EGF
5polyadenosine diphosphate ribose4510.4PARP1, CASP3
6d-api4510.4PARP1, CASP3
7oridonin4510.4PARP1, CASP3
8se-methylselenocysteine45 2411.3PARP1, CASP3
9deta nonoate4510.3PARP1, EIF4E
104,6-diamidino-2-phenylindole4510.3PARP1, CASP3
11beta-lapachone4510.3PARP1, CASP3
12indole-3-carbinol4510.3PARP1, CDH1, CASP3
13manumycin4510.2PARP1, EGF, CASP3
14ifn-alpha4510.2EIF4E, IL10, STAT2
15celecoxib45 60 29 50 11 2415.2CASP3, CDH1, PARP1
16rottlerin4510.1CASP3, EGF, PARP1
17sanguinarine4510.1PARP1, CASP3
18irinotecan45 50 1112.1EGF, CDH1, PARP1
19exisulind4510.1CDH1, CASP3
20dexamethasone45 50 29 1113.0TXN, CDH1, PARP1
21h2o24510.0EGF, EIF4E, PARP1
22sulforaphane4510.0PARP1, CASP3, TXN
23rotenone4510.0TXN, CASP3, PARP1
24gemcitabine45 50 1112.0CASP3, EGF, IL10, PARP1
25geldanamycin45 50 60 1113.0EGF, CDH1, PARP1
26u0126459.9EGF, CASP3
2715-deoxy-delta-12,14-prostaglandin j2459.9IL10, CASP3, TXN
28suberoylanilide hydroxamic acid459.9PARP1, CDH1, CASP3, TXN
29mg 13245 6010.9CASP3, EGF, CDH1, EIF4E, PARP1
30docetaxel45 50 60 1112.9TXN, CASP3, CDH1, PARP1
31genistein45 29 60 2 11 2414.8CASP3, STAT2, EGF, CDH1, PARP1
324-hydroxynonenal45 2410.8TXN, CASP3, IL10, PARP1
33arsenite45 2410.8PARP1, EIF4E, CASP3, TXN
34rapamycin459.8CASP3, EGF, CDH1, IL10, EIF4E
35agar459.8TXN, EGF, CDH1, EIF4E
36paclitaxel45 50 1111.8PARP1, CDH1, EGF, CASP3
37etoposide45 50 60 1112.7PARP1, EIF4E, CDH1, CASP3, TXN
38n acetylcysteine459.7TXN, CASP3, CDH1, EIF4E, PARP1
39sb 20358045 6010.6CASP3, EGF, CDH1, IL10, EIF4E, PARP1
40ly294002459.6CASP3, EGF, CDH1, IL10, EIF4E, PARP1
41actinomycin d459.6TXN, CASP3, EGF, EIF4E, PARP1
42mitomycin c459.6TXN, IL10, TP63
43pd 98,059459.6KLF4, CASP3, EGF, CDH1, EIF4E, PARP1
44doxorubicin45 50 1111.4TXN, CASP3, EGF, CDH1, PARP1, TP63
45cisplatin45 50 60 1112.3TXN, CASP3, EGF, CDH1, EIF4E, PARP1
46cysteine459.2TXN, CASP3, EGF, CDH1, EIF4E, RARRES2
47vegf459.0TXN, CASP3, EGF, CDH1, IL10, EIF4E
48retinoic acid45 249.7TP63, TXN, CASP3, STAT2, EGF, CDH1
49serine458.5TXN, CASP3, STAT2, EGF, CDH1, EIF4E

GO Terms for genes affiliated with Skin Squamous Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.1CDH1, EGF
2cellular response to lithium ionGO:07128510.1CEBPA, CDH1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.0CDH1, CASP3
4negative regulation of B cell proliferationGO:0308899.7IL10, CASP3
5negative regulation of transcription from RNA polymerase II promoterGO:0001229.2KLF4, TXN, PARP1, CEBPA, TP63
6positive regulation of transcription, DNA-dependentGO:0458938.8TP63, KLF4, CRLF3, EGF, TRIM16, CDH1

Molecular functions related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2TP63, TXN, CASP3, STAT2, EGF, SHFM1

Products for genes affiliated with Skin Squamous Cell Carcinoma

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Sources for Skin Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet