MCID: SKN022
MIFTS: 51

Skin Squamous Cell Carcinoma malady

Cancer diseases, Skin diseases categories
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Summaries for Skin Squamous Cell Carcinoma

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Disease Ontology:8 A skin carcinoma that has material basis in squamous cells.

MalaCards based summary: Skin Squamous Cell Carcinoma, also known as squamous cell carcinoma of skin, is related to medulloblastoma and melanoma. An important gene associated with Skin Squamous Cell Carcinoma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are Alpha6-Beta4 Integrin Signaling Pathway and TP53 network. The compounds manumycin and z-vad-fmk have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and monocytes, and related mouse phenotypes are no phenotypic analysis and vision/eye.

Aliases & Classifications for Skin Squamous Cell Carcinoma

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Skin Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Skin Squamous Cell Carcinoma 8
Squamous Cell Carcinoma of Skin 62
 
Epidermoid Skin Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:3151
SNOMED-CT57 254651007
NCIt39 C4819

Related Diseases for Skin Squamous Cell Carcinoma

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Diseases related to Skin Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma30.4TP53, PARP1, CASP3
2melanoma28.2STAT2, IL10, TXN, TP63, TP53, PARP1
3epidermodysplasia verruciformis10.4
4pseudovascular skin squamous cell carcinoma10.4
5neuroepithelioma10.2CASP3, NET1
6myeloid leukemia10.2PARP1, STAT2, CASP3
7bronchiolo-alveolar adenocarcinoma10.2CDH1, EIF4E
8xeroderma pigmentosum10.2
9anal margin squamous cell carcinoma10.2
10spindle cell carcinoma10.2
11keratoacanthoma10.2
12papilloma10.2
13esophageal cancer10.2CDH1, TP53
14oral lichen planus10.2CASP3, TP63
15precursor t-cell acute lymphoblastic leukemia10.1CASP3, PARP1, TXN
16nasopharynx carcinoma10.1CDH1, TP53
17actinic keratosis10.1TP63, TP53
18gastric adenocarcinoma10.1CASP3, KLF4, CDH1
19tongue squamous cell carcinoma10.1CDH1, EGF, EIF4E
20stomach cancer10.1CDH1, TP53
21squamous cell carcinoma of the head and neck10.1TP53, EIF4E, EGF
22ataxia telangiectasia10.1CASP3, TP53, PARP1
23breast cancer, invasive ductal10.1CDH1, TP53
24lung cancer10.1PARP1, CDH1, TP53
25familial adenomatous polyposis10.0TP53, KLF4, CDH1
26ductal carcinoma in situ10.0TP53, CDH1
27cholangiocarcinoma10.0CDH1, EIF4E, TP53
28bladder transitional cell carcinoma10.0CDH1, TP53, CASP3
29cervical squamous cell carcinoma10.0TP63, EGF
30relapsing-remitting multiple sclerosis10.0IL10, IFNA1
31malignant mesothelioma10.0TXN, TP63, CDH1
32pancreatic cancer10.0CASP3, CDH1, EGF
33tubular adenocarcinoma10.0TP63, CDH1
34glioblastoma multiforme10.0TP53, PARP1, EIF4E, EGF
35b-cell lymphomas10.0TXN, PARP1, CASP3, TP53
36brain cancer9.9CASP3, EGF, TP53, EIF4E
37vascular disease9.9CASP3, IL10, TXN, TP53
38burkitt's lymphoma9.9CASP3, IFNA1, PARP1
39malignant glioma9.9TP53, EGF, CASP3, PARP1
40hepatitis c9.9IL10, IFNA1, TXN
41oral cancer9.9CDH1, TP53, PARP1, CASP3
42transitional cell carcinoma9.9TP53, CDH1, TP63
43breast ductal carcinoma9.9TP53, CDH1
44thyroid cancer, anaplastic9.9CASP3, TP53, EGF, CDH1
45colon adenocarcinoma9.8EIF4E, CASP3, PARP1, CDH1, EGF
46kidney cancer9.8TP53, CDH1, IFNA1
47laryngeal squamous cell carcinoma9.8TP63, TP53, CDH1, EIF4E
48retinoblastoma9.8PARP1, CEBPA, CASP3, EGF, TP53
49endometrial carcinoma9.8EGF, CDH1, TP53
50glioblastoma9.8TP53, EIF4E, PARP1, CASP3, EGF

Graphical network of the top 20 diseases related to Skin Squamous Cell Carcinoma:



Diseases related to skin squamous cell carcinoma

Symptoms for Skin Squamous Cell Carcinoma

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Drugs & Therapeutics for Skin Squamous Cell Carcinoma

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Drug clinical trials:

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Search NIH Clinical Center for Skin Squamous Cell Carcinoma

Genetic Tests for Skin Squamous Cell Carcinoma

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Anatomical Context for Skin Squamous Cell Carcinoma

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MalaCards organs/tissues related to Skin Squamous Cell Carcinoma:

32
Skin, Lung, Monocytes

Animal Models for Skin Squamous Cell Carcinoma or affiliated genes

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Publications for Skin Squamous Cell Carcinoma

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Articles related to Skin Squamous Cell Carcinoma:

(show all 42)
idTitleAuthorsYear
1
Advanced skin squamous cell carcinoma: role of radiotherapy. (24563891)
2014
2
Clinical significance of methylation of E-cadherin and p14ARF gene promoters in skin squamous cell carcinoma tissues. (25126184)
2014
3
Lung transplant recipients receiving voriconazole and skin squamous cell carcinoma risk in Australia. (25358582)
2014
4
Lgr5-positive cells are cancer stem cells in skin squamous cell carcinoma. (25135431)
2014
5
Sox2, a marker for stem-like tumor cells in skin squamous cell carcinoma and hedgehog subgroup medulloblastoma. (25061226)
2014
6
Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. (24917395)
2014
7
HPV type 16-induced skin squamous cell carcinoma located on the groin of immunocompetent patients. (24116660)
2013
8
The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice. (23428654)
2013
9
Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. (23460078)
2013
10
Expression and function of NET-1 in human skin squamous cell carcinoma. (24196235)
2013
11
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. (22824799)
2013
12
Pronounced allelic imbalance at D9S162 in skin squamous cell carcinoma of organ transplant recipients. (22508773)
2012
13
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. (23188079)
2012
14
Upregulation of TCTP expression in human skin squamous cell carcinoma increases tumor cell viability through anti-apoptotic action of the protein. (22969908)
2012
15
Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo. (21493306)
2011
16
C/EBPI+ expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPI+ confers susceptibility to UVB-induced skin squamous cell carcinomas. (21346772)
2011
17
The incidence of skin squamous cell carcinoma in Osijek-Baranja County--an epidemiological study. (22220409)
2011
18
Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma. (21480386)
2011
19
Association of the DSS1 c.143G>A polymorphism with skin squamous cell carcinoma. (20220765)
2010
20
Immune phenotype of peripheral blood cells and skin squamous cell carcinoma in organ transplant recipients. (20441422)
2010
21
Expression, clinical and pathological significance of KIAA1173 gene in skin squamous cell carcinoma]. (20646595)
2010
22
Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy. (19077103)
2009
23
The preventive effect of calcitriol on skin squamous cell carcinoma may be due to its effect on prostaglandin E2 metabolism and biologic activity. (20021988)
2009
24
Functions of NET-1 gene in skin squamous cell carcinoma cell line (A431): a siRNA study]. (20078975)
2009
25
Desipramine inhibits the growth of a mouse skin squamous cell carcinoma cell line and affects glucocorticoid receptor-mediated transcription. (19575421)
2009
26
Thioredoxin upregulation by 5-aminolaevulinic acid-based photodynamic therapy in human skin squamous cell carcinoma cell line. (18477133)
2008
27
Downregulation of tazarotene induced gene-2 (TIG2) in skin squamous cell carcinoma. (18955196)
2008
28
Nuclear KrA1ppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis. (18376139)
2008
29
Significance of eIF4E expression in skin squamous cell carcinoma. (17689990)
2007
30
Randomized trial of adjuvant 13-cis-retinoic acid and interferon alfa for patients with aggressive skin squamous cell carcinoma. (17513803)
2007
31
Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon alpha action in skin squamous cell carcinoma cells. (12748307)
2003
32
Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. (12535204)
2003
33
Opposite effect of stable transfection of bioactive transforming growth factor-beta 1 (TGF beta 1) versus exogenous TGF beta 1 treatment on expression of 92-kDa type IV collagenase in mouse skin squamous cell carcinoma CH72 cells. (9210959)
1997
34
Multiple metachronous skin squamous cell carcinomas and epidermodysplasia verruciformis in the head region: a human papilloma virus-associated disease. (7848644)
1994
35
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. (7689080)
1993
36
Establishment of highly metastatic tumor clones derived from a skin squamous cell carcinoma (SqC-NH), D-1 and F-3, with distinct features of pulmonary metastases. (8319380)
1993
37
Autocrine secretion of an EGF-like substance by a cell line (HSC-1) derived from a human skin squamous cell carcinoma. (1878344)
1991
38
Analysis of cellular DNA content using flow cytometry in skin squamous cell carcinoma and its relationship to clinical behaviors. (1664278)
1991
39
Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from a xeroderma pigmentosum patient. (3164238)
1988
40
Monocyte Fc-IgG receptors expression and soluble suppressor factor in skin squamous cell carcinoma. (6198840)
1983
41
Metastatic potential of biologic variants of skin squamous cell carcinoma. (7130943)
1982
42
Establishment of a cell line of human skin squamous cell carcinoma in vitro. (7284243)
1981

Variations for Skin Squamous Cell Carcinoma

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Expression for genes affiliated with Skin Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Skin Squamous Cell Carcinoma

Search GEO for disease gene expression data for Skin Squamous Cell Carcinoma.

Pathways for genes affiliated with Skin Squamous Cell Carcinoma

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Pathways related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8EIF4E, CASP3, CD151
2
Show member pathways
9.8TP63, TP53
3
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.6STAT2, EGF, TP53
49.6CASP3, EIF4E, TP53
5
Show member pathways
9.6TP53, CASP3, EIF4E
6
Show member pathways
9.6CASP3, PARP1, TP53
7
Show member pathways
9.6EGF, CASP3, TP53
89.5CDH1, CASP3, TP53
9
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.5TP53, TP63, CASP3
10
Show member pathways
Type III interferon signaling37
9.4STAT2, IFNA1, IL10
11
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.3TP53, CDH1, SHFM1, CASP3
12
Show member pathways
9.3EGF, NET1, CASP3
139.2CASP3, EGF, TP53, CDH1
149.2EGF, CASP3, CDH1, TP53
159.1CASP3, PARP1, TXN
169.1TXN, CEBPA, IL10
17
Show member pathways
9.1CASP3, TP53, STAT2, IFNA1
189.1TP53, STAT2, IFNA1, EGF
199.1EIF4E, IFNA1, TP53, EGF
209.0KLF4, CDH1, TP53, PARP1
21
Show member pathways
Signal transduction PTEN pathway60
9.0TP53, CEBPA, CASP3, CDH1, EGF
229.0CDH1, EGF, CEBPA, TP53, CASP3
23
Show member pathways
8.9TP53, CASP3, CDH1, NET1
248.9STAT2, IFNA1, EIF4E, NET1
25
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8CASP3, IL10, IFNA1, STAT2, TP53
26
Show member pathways
8.7CASP3, EIF4E, EGF, NET1, TP53
27
Show member pathways
8.6STAT2, CEBPA, TP53, IL10, CASP3, EIF4E
28
Show member pathways
8.5CEBPA, IFNA1, EGF, CASP3, IL10, TP53
29
Show member pathways
8.1IL10, STAT2, TP53, CASP3, CDH1, EGF
30
Show member pathways
7.6TP53, IL10, IFNA1, STAT2, NET1, CDH1

Compounds for genes affiliated with Skin Squamous Cell Carcinoma

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Compounds related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1manumycin449.9EGF, PARP1, CASP3
2z-vad-fmk44 6110.9CASP3, PARP1, TP53
3p113449.9IFNA1, STAT2
4sulindac sulfide449.8EGF, CASP3, TP53
5indole-3-carbinol449.7PARP1, TP53, CASP3, CDH1
6cd 437449.6PARP1, TP53, CASP3
7temozolomide44 1110.6IFNA1, PARP1, TP53
8triptolide449.6TP53, PARP1, CASP3
9geldanamycin44 50 61 1112.6PARP1, CDH1, EGF, TP53
10ifn-alpha449.6EIF4E, IL10, STAT2, IFNA1
11noxa449.6CASP3, TP63, TP53
12bcnu449.5PARP1, TP53, IFNA1
13gemcitabine44 50 1111.4EGF, TP53, PARP1, IL10, CASP3
14egcg449.4TP53, EGF, CDH1, CASP3, PARP1
15paclitaxel44 50 1111.3CDH1, CASP3, PARP1, TP53, EGF
16thymidylate449.2IL10, IFNA1, TP53, CDH1
17camptothecin44 61 1111.2PARP1, TP53, CASP3, IFNA1
184-hydroxynonenal44 2410.2TXN, CASP3, PARP1, IL10
19mg 13244 6110.2EGF, CDH1, CASP3, PARP1, TP53, EIF4E
20irinotecan44 50 1111.1TP53, PARP1, EGF, IFNA1, CDH1
215fluorouracil449.1CDH1, EGF, CASP3, IFNA1, TP53
22genistein44 28 61 2 24 1114.0CASP3, STAT2, PARP1, EGF, CDH1
23butyrate449.0TP53, CASP3, KLF4, EGF, CDH1
242-chlorodeoxyadenosine449.0PARP1, TP53, IFNA1
25pd 98,059449.0PARP1, CDH1, CASP3, KLF4, EGF, EIF4E
26resveratrol44 61 24 1112.0PARP1, CASP3, TP53, TXN
27mitomycin c448.9IL10, TP53, TP63, TXN
28rapamycin448.9IFNA1, CDH1, CASP3, EIF4E, IL10, EGF
29suberoylanilide hydroxamic acid448.9TXN, TP53, PARP1, CASP3, CDH1
30sb 20358044 619.9EGF, CDH1, CASP3, IL10, PARP1, TP53
31ly294002448.9EIF4E, IL10, PARP1, TP53, CASP3, CDH1
32hydroxyurea44 50 1110.8TXN, TP53, IFNA1, IL10
33n acetylcysteine448.6TXN, EIF4E, CDH1, CASP3, PARP1, TP53
34adriamycin448.6CDH1, CASP3, TP53, TXN, IFNA1
35h2o2448.5PARP1, TXN, CASP3, EGF, EIF4E, TP53
36thymidine44 249.5KLF4, IFNA1, EGF, IL10, TP63, TP53
37arsenite44 249.4CASP3, IFNA1, TXN, EIF4E, PARP1, TP53
38docetaxel44 50 61 1111.3TXN, PARP1, IFNA1, CDH1, CASP3, TP53
39retinoid448.3CDH1, RARRES2, IFNA1, TXN, TP53
40estrogen448.2TP53, EGF, TXN, CEBPA, CDH1, EIF4E
41actinomycin d448.1TP53, CASP3, EIF4E, TXN, IFNA1, PARP1
42dexamethasone44 50 28 1111.1EGF, PARP1, CEBPA, CDH1, IL10, TXN
43etoposide44 50 61 1111.1CDH1, EIF4E, CASP3, IFNA1, PARP1, TP53
44cysteine448.0RARRES2, CASP3, CDH1, CD151, EIF4E, PARP1
45cycloheximide447.8CASP3, IFNA1, EIF4E, PARP1, EGF, TXN
46doxorubicin44 50 119.7TP63, PARP1, IFNA1, CASP3, CDH1, TP53
47cisplatin44 50 61 1110.5EIF4E, TXN, TP63, TP53, PARP1, IFNA1
48serine447.4STAT2, EIF4E, RARRES2, CASP3, IFNA1, TXN
49vegf447.2EIF4E, CASP3, IL10, IFNA1, TP53, TP63
50retinoic acid44 247.6EGF, CDH1, EIF4E, RARRES2, CASP3, IFNA1

GO Terms for genes affiliated with Skin Squamous Cell Carcinoma

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Cellular components related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.2KLF4, TP53, TP63
2nucleoplasmGO:0056548.1CASP3, TXN, TP63, TP53, PARP1, STAT2
3cytosolGO:0058297.1TXN, TP63, TP53, NET1, STAT2, CASP3

Biological processes related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:03022510.2PARP1, CEBPA
2regulation of protein localization to cell surfaceGO:200000810.1EGF, CDH1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.1CDH1, CASP3
4negative regulation of B cell proliferationGO:03088910.1CASP3, IL10
5cellular response to lithium ionGO:07128510.1CDH1, CEBPA
6mitotic G1 DNA damage checkpointGO:03157110.0TP63, TP53
7DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.0TP63, TP53
8response to X-rayGO:0101659.9TP63, TP53
9neuron apoptotic processGO:0514029.8CASP3, TP53, TP63
10release of cytochrome c from mitochondriaGO:0018369.7CASP3, TP53
11cellular response to ionizing radiationGO:0714799.5NET1, TP53
12cell agingGO:0075699.5TP53, TP63
13positive regulation of DNA bindingGO:0433889.4EGF, TXN
14negative regulation of apoptotic processGO:0430669.2TP63, TP53, IL10, CASP3
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.7TP63, TP53, PARP1, CEBPA, IL10, KLF4
16positive regulation of transcription, DNA-templatedGO:0458938.6EGF, CDH1, KLF4, IL10, TP53, TP63
17negative regulation of transcription from RNA polymerase II promoterGO:0001228.2TXN, TP63, TP53, PARP1, CEBPA, KLF4

Molecular functions related to Skin Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.1TP53, TP63, KLF4
2transcription regulatory region DNA bindingGO:0442129.0KLF4, CEBPA, TP53, TP63
3identical protein bindingGO:0428029.0STAT2, TP53, TP63, PARP1
4sequence-specific DNA binding transcription factor activityGO:0037008.8STAT2, CEBPA, KLF4, TP53, TP63
5protein bindingGO:0055155.8STAT2, PARP1, CASP3, RARRES2, KLF4, EIF4E

Products for genes affiliated with Skin Squamous Cell Carcinoma

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Sources for Skin Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet