TAG
MCID: SKN023
MIFTS: 49

Skin Tag (TAG) malady

Skin diseases category
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Summaries for Skin Tag

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Wikipedia:65 An acrochordon (plural acrochorda, and also known as a (cutaneous) skin tag, or fibroepithelial polyp,)... more...

MalaCards based summary: Skin Tag, also known as fibroepithelial polyp of skin, is related to acanthosis nigricans and gestational diabetes. An important gene associated with Skin Tag is EFTUD2 (elongation factor Tu GTP binding domain containing 2), and among its related pathways are Adipogenesis and Peptide hormone metabolism. The compounds exenatide and pramlintide have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Aliases & Classifications for Skin Tag

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT
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Skin Tag, Aliases & Descriptions:

Name: Skin Tag 8 62
Fibroepithelial Polyp of Skin 8 62
Fibroepithelial Polyp 8 62
Cutaneous Tag 8 62
 
Soft Fibroma 8 62
Skin Tags 44 62
Skin Tag Nos 8
Tag 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:6873
NCIt39 C3337, C3374

Related Diseases for Skin Tag

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Diseases related to Skin Tag via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1acanthosis nigricans30.6INS, LEP
2gestational diabetes30.2INS, LEP
3infertility29.7ESR1, INS, LEP
4fibroepithelial polyp of urethra10.6
5fibroepithelial polyp of the anus10.5
6vulva fibroepithelial polyp10.5
7rabson-mendenhall syndrome10.4INS
8acquired generalized lipodystrophy10.4LEP
9ovarian disease10.3ESR1
10fibroma10.3
11cystitis cystica10.2
12ureteral obstruction10.2
13fibrous histiocytoma10.2
14familial adenomatous polyposis10.2
15ureterocele10.2
16intussusception10.2
17verrucous carcinoma10.2
18cystitis10.2
19endometriosis10.2
20hemangiopericytoma10.2
21histiocytoma10.2
22ileus10.2
23cleft palate10.2
24microcephaly10.2
25microphthalmia10.2
26lipoma10.2
27mental retardation10.2
28insulin resistance10.2
29familial partial lipodystrophy10.2LEP, INS
30fetal macrosomia10.2LEP, INS
31congenital generalized lipodystrophy type 210.2INS, LEP
32anovulation10.2LEP, INS
33eating disorder10.2INS, LEP
34amenorrhea10.1INS, LEP
35growth hormone deficiency10.1LEP, INS
36morbid obesity10.1INS, LEP
37hypopituitarism10.1INS, LEP
38hyperandrogenism10.1INS, LEP
39lipodystrophy10.1LEP, INS
40prader-willi syndrome10.1LEP, INS
41acromegaly10.1INS, LEP
42atherosclerosis10.1INS, LEP
43hypogonadism10.1LEP, INS
44glucose intolerance10.1LEP, INS
45hyperthyroidism10.1LEP, INS
46hypertriglyceridemia10.1LEP, INS
47molluscum contagiosum10.1
48dermatofibrosarcoma protuberans10.1
49primary hyperoxaluria10.1INS, LEP
50polycystic ovary syndrome10.1LEP, INS

Graphical network of the top 20 diseases related to Skin Tag:



Diseases related to skin tag

Symptoms for Skin Tag

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Drugs & Therapeutics for Skin Tag

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Drug clinical trials:

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Search NIH Clinical Center for Skin Tag

Genetic Tests for Skin Tag

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Anatomical Context for Skin Tag

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MalaCards organs/tissues related to Skin Tag:

32
Skin, Colon

Animal Models for Skin Tag or affiliated genes

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Publications for Skin Tag

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Articles related to Skin Tag:

(show all 43)
idTitleAuthorsYear
1
Role of mast cells in skin tag development: an immunohistochemical study. (25291860)
2014
2
An infant with PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, and skin tag) syndrome misdiagnosed as diaper rash. (24948350)
2014
3
Pai syndrome: median cleft lip, corpus callosum lipoma, and fibroepithelial skin tag. (24741390)
2014
4
Case report of a very large skin tag in an unusual location that grew rapidly during pregnancy. (24611972)
2014
5
Anal atresia, coloboma, microphthalmia, and nasal skin tag in a female patient with 3.5a88Mb deletion of 3q26 encompassing SOX2. (23613260)
2013
6
Skin tag of the nipple with blister formation: Two case reports. (24127900)
2013
7
Association of acanthosis nigricans and skin tags with insulin resistance. (22481657)
2012
8
Skin tag (acrochordon) on labium majus in an infertile female. (22980625)
2012
9
An association of human papillomaviruses low risk and high risk subtypes with skin tag. (23493098)
2012
10
Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels. (22615504)
2012
11
Atypical lipomatous tumor/"well-differentiated liposarcoma" of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases. (21358383)
2011
12
Skin tags, leptin, metabolic syndrome and change of the life style. (21860156)
2011
13
Skin tag and acanthosis nigricans: do they have a predictive value for gestational diabetes mellitus? (21472660)
2011
14
Increased tissue leptin hormone level and mast cell count in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (20826994)
2010
15
Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? (19453787)
2010
16
A study of androgen and estrogen receptors alpha, beta in skin tags. (20418971)
2010
17
Anal skin tag: do not injure the elephants. (20463592)
2010
18
Mammary skin tag in a 2-year-old girl: a long-lasting adnexal polyp of neonatal skin? (19840327)
2009
19
Verruca plus acrochordon: an 'over the top' skin tag. (19747304)
2009
20
Mandibulofacial syndrome with growth and mental retardation, microcephaly, ear anomalies with skin tags, and cleft palate in a mother and her son: autosomal dominant or X-linked syndrome? (19921636)
2009
21
Serum leptin, atherogenic lipids and glucose levels in patients with skin tags. (20049263)
2009
22
Four limb syndactyly, constriction rings and skin tags; amniotic bands or disorganization-like syndrome. (18978653)
2008
23
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
24
Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. (18397315)
2008
25
Skin tag removal [corrected]. (18791098)
2008
26
Basal cell carcinoma in a skin tag. (18779117)
2008
27
Rhabdomyomatous mesenchymal hamartoma presenting as a skin tag in the sternoclavicular area. (18158576)
2007
28
Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. (17988334)
2007
29
Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. (16952203)
2006
30
'Myxopapillary' ependymal rest presenting as a pre-sacral skin tag. (15875743)
2005
31
Skin tag. (15604558)
2005
32
Marzouk skin tag two-stage urethroplasty for the repair of complex cases of hypospadias. (14678181)
2004
33
Eccrine nevus presenting as a perianal skin tag: a case report and review of the literature. (12142620)
2002
34
Blister on a skin tag. (12218240)
2002
35
Multiple congenital anomalies syndrome: growth and mental retardation, microcephaly, preauricular skin tags, cleft palate, camptodactyly, and distal limb anomalies. Report on two unrelated Brazilian patients. (10528252)
1999
36
A case of perineal schwannoma resembling a skin tag. (10554437)
1999
37
Hemifacial microsomia in a newborn with hypoplastic skin lesions, an eyelid skin tag, and microphthalmia: an unusual presentation of Delleman syndrome. (9823495)
1998
38
Guess what! Skin tag (acrochordon) on the labium majus. (10026017)
1998
39
Cutaneous pseudosarcomatous polyp--another variant of dermal lipoma or only an "ancient" skin tag? (9243368)
1997
40
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
41
A method for removing the acrochordon (skin tag). (2308255)
1990
42
The accessory tragus--no ordinary skin tag. (2646335)
1989
43
Cutaneous skin tag of the foot. (6822720)
1983

Variations for Skin Tag

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Expression for genes affiliated with Skin Tag

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Expression patterns in normal tissues for genes affiliated with Skin Tag

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Pathways for genes affiliated with Skin Tag

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Pathways related to Skin Tag according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, LEP
2
Show member pathways
9.3INS, LEP
39.3INS, LEP
4
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.3INS, LEP
5
Show member pathways
9.3LEP, INS
69.3LEP, INS
7
Show member pathways
FOXA transcription factor networks37
9.1INS, ESR1
8
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.5INS, ESR1, LEP
9
Show member pathways
8.0ESR1, PTCH1, LEP, INS

Compounds for genes affiliated with Skin Tag

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Compounds related to Skin Tag according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1exenatide44 1110.8LEP, INS
2pramlintide44 1110.8LEP, INS
3sibutramine44 1110.8INS, LEP
4beta-hydroxybutyrate449.8INS, LEP
5acipimox44 2810.7LEP, INS
6intralipid449.7INS, LEP
7nash449.7INS, LEP
8telmisartan44 28 1111.7INS, LEP
9cortisone44 2410.7LEP, INS
10orlistat44 61 1111.7LEP, INS
11thiazolidinedione449.7INS, LEP
128-isoprostane449.7INS, LEP
13aicar44 24 1111.7INS, LEP
14dehydroepiandrosterone sulfate449.7LEP, INS
15fenofibrate44 50 1111.7LEP, INS
16glibenclamide44 28 50 6112.7LEP, INS
17c-peptide449.7INS, LEP
18metformin44 50 1111.6INS, LEP
19olanzapine44 50 28 24 1113.6LEP, INS
20dhea449.6LEP, INS
21triacylglycerol449.6INS, LEP
22pioglitazone28 44 50 1112.6INS, LEP
23androstenedione44 2410.6INS, LEP
24desogestrel44 1110.6INS, ESR1
25uric acid44 2410.6LEP, INS
26clomiphene citrate449.5ESR1, INS
27rosiglitazone28 44 50 24 1113.5LEP, INS
28troglitazone44 28 61 1112.5LEP, INS
29megestrol acetate449.4LEP, ESR1
30tibolone449.4LEP, ESR1
31letrozole44 50 61 1112.4ESR1, LEP
32naloxone44 28 50 1112.4ESR1, LEP
33carbohydrates449.3LEP, INS
34acth449.3INS, LEP
35estrone44 28 24 1112.2ESR1, LEP
36thyroxine44 2410.2INS, LEP
37dihydrotestosterone44 28 24 1112.1ESR1, LEP
38glycerol44 24 1111.0INS, LEP
39gnrh448.9ESR1, LEP, INS
40ly294002448.9LEP, INS, ESR1
41paraffin448.9LEP, PTCH1, ESR1
42testosterone44 61 24 1111.8ESR1, LEP, INS
43estrogen448.6LEP, INS, ESR1

GO Terms for genes affiliated with Skin Tag

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Biological processes related to Skin Tag according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localizationGO:0328809.6PTCH1, INS
2positive regulation of insulin receptor signaling pathwayGO:0466289.6INS, LEP
3positive regulation of MAPK cascadeGO:0434109.4INS, LEP
4glucose homeostasisGO:0425939.4INS, PTCH1
5positive regulation of nitric-oxide synthase activityGO:0510009.4INS, ESR1
6positive regulation of nitric oxide biosynthetic processGO:0454299.3ESR1, INS
7glucose metabolic processGO:0060069.3INS, LEP
8negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.3PTCH1, ESR1
9regulation of insulin secretionGO:0507969.2INS, LEP
10response to estradiolGO:0323559.2PTCH1, ESR1
11energy reserve metabolic processGO:0061129.0LEP, INS

Molecular functions related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3LEP, INS

Products for genes affiliated with Skin Tag

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Sources for Skin Tag

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet