TAG
MCID: SKN023
MIFTS: 47

Skin Tag (TAG) malady

Skin category

Summaries for Skin Tag

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 An acrochordon (plural acrochorda, and also known as a (cutaneous) skin tag, or fibroepithelial polyp,)... more...

MalaCards: Skin Tag, also known as fibroepithelial polyp of skin, is related to adenocarcinoma and graves' disease. An important gene associated with Skin Tag is PTCH1 (patched 1), and among its related pathways are DNA replication initiation and HTLV-I infection. The compounds purvalanol a and exenatide have been mentioned in the context of this disorder. Affiliated tissues include colon and skin, and related mouse phenotypes are skeleton and tumorigenesis.

Aliases & Classifications for Skin Tag

Sources:
8Disease Ontology, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

skin tag 8 61
fibroepithelial polyp of skin 8
fibroepithelial polyp 8
cutaneous tag 8
skin tag nos 8
soft fibroma 8
skin tags 45
tag 8


External Ids:

Disease Ontology8 DOID:6873
NCIt40 C3374, C3337

Related Diseases for Skin Tag

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Skin Tag via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.1HSPA8, RB1, TERT, PTCH1, ESR1
2graves' disease30.1HSPA8
3gestational diabetes30.0LEP, INS, LSL
4coronary heart disease29.9INS, LEP
5atherosclerosis29.9LEP, INS, LSL
6colorectal cancer29.7HSPA8, TERT
7vaccinia29.7REV3L, POLD1, POLE, POLA1
8glucose intolerance29.7LSL, INS, LEP
9xeroderma pigmentosum29.7POLA1, POLE, POLD1, REV3L, PTCH1
10hepatitis b29.7HSPA8, POLA1, POLE, POLD1, REV3L, TERT
11vulva fibroepithelial polyp10.5
12fibroepithelial polyp of the anus10.4
13fibroepithelial polyp of urethra10.4
14acanthosis nigricans10.2
15micro syndrome10.2
16ureteral obstruction10.2
17cystitis cystica10.2
18fibrous histiocytoma10.2
19familial adenomatous polyposis10.2
20glandular cystitis10.2
21ureterocele10.2
22intussusception10.2
23verrucous carcinoma10.2
24squamous cell carcinoma10.2
25ileus10.2
26microcephaly10.2
27microphthalmia10.2
28cleft palate10.2
29n syndrome10.2
30skin lipoma10.2
31mental retardation10.2
32insulin resistance10.2
33microcephaly - cleft palate10.2
34thalassemia10.1
35macrostomia - preauricular tags - external ophthalmoplegia10.1
36molluscum contagiosum10.1
37dermatofibrosarcoma10.1
38dermatofibrosarcoma protuberans10.1
39parkinson's disease10.1
40hepatitis c10.1
41alpha thalassemia10.1
42azoospermia10.1
43multiple sclerosis 110.1
44lung cancer susceptibility10.1
45intellectual deficit - hypoplastic corpus callosum - preauricular tag10.1
46prolactinoma10.0
47goldenhar syndrome10.0
48autosomal dominant microcephaly10.0
49coloboma10.0
50syndactyly10.0

Graphical network of the top 20 diseases related to Skin Tag:



Diseases related to skin tag

Clinical Features for Skin Tag

Drugs & Therapeutics for Skin Tag

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Tag

Drug clinical trials:

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Search NIH Clinical Center for Skin Tag

Search CenterWatch for Skin Tag

Genetic Tests for Skin Tag

Anatomical Context for Skin Tag

Sources:
33MalaCards
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MalaCards organs/tissues related to Skin Tag:

33
Colon, Skin

Animal Models for Skin Tag or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Skin Tag

Sources:
51PubMed
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Articles related to Skin Tag:

(show all 12)
idTitleAuthorsYear
1
Association of acanthosis nigricans and skin tags with insulin resistance. (22481657)
2012
2
Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels. (22615504)
2012
3
Skin tags, leptin, metabolic syndrome and change of the life style. (21860156)
2011
4
Increased tissue leptin hormone level and mast cell count in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (20826994)
2010
5
A study of androgen and estrogen receptors alpha, beta in skin tags. (20418971)
2010
6
Mandibulofacial syndrome with growth and mental retardation, microcephaly, ear anomalies with skin tags, and cleft palate in a mother and her son: autosomal dominant or X-linked syndrome? (19921636)
2009
7
Serum leptin, atherogenic lipids and glucose levels in patients with skin tags. (20049263)
2009
8
Four limb syndactyly, constriction rings and skin tags; amniotic bands or disorganization-like syndrome. (18978653)
2008
9
Fibroepithelial papillomatosis ("skin tags") in Rabson-Mendenhall syndrome. (18405695)
2008
10
Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. (18397315)
2008
11
Multiple congenital anomalies syndrome: growth and mental retardation, microcephaly, preauricular skin tags, cleft palate, camptodactyly, and distal limb anomalies. Report on two unrelated Brazilian patients. (10528252)
1999
12
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994

Genetic Variations for Skin Tag

Expression for genes affiliated with Skin Tag

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Tag

Search GEO for disease gene expression data for Skin Tag.

Pathways for genes affiliated with Skin Tag

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
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Pathways related to Skin Tag according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8POLA1, POLE
29.5TERT, POLD1, POLE, RB1
39.5POLD1, POLE, POLA1
4
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9.5POLD1, POLE, POLA1
5
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9.5RB1, POLE, POLD1, ESR1
6
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9.3POLA1, POLE, POLD1, TERT
7
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9.3POLA1, POLE, POLD1, TERT
8
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9.0RB1, POLA1, POLE, POLD1, TERT
9
Hide members
9.0HSPA8, RB1, POLA1, POLE, POLD1
10
Hide members
9.0TERT, INS, POLD1, POLE, POLA1

Compounds for genes affiliated with Skin Tag

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Skin Tag according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1purvalanol a45 60 1112.3RB1, POLD1
2exenatide45 1111.3INS, LEP
3goserelin45 29 1112.2LSL
4desogestrel45 1111.1INS, ESR1
5pramlintide45 1111.1INS, LEP
6Cladribine1110.0POLA1, POLE
7tibolone459.9LSL, LEP, ESR1
8sibutramine45 1110.9INS, LEP, LSL
9megestrol acetate459.9ESR1, LEP
10beta-hydroxybutyrate459.9INS, LSL, LEP
11acipimox45 2910.9LEP, INS, LSL
12nash459.9INS, LSL, LEP
13intralipid459.9LSL, INS, LEP
14adpribose459.9RB1, TERT, HSPA8
15orlistat45 60 1111.9INS, LEP, LSL
16dehydroepiandrosterone sulfate459.9LSL, LEP, INS
17raloxifene45 29 50 1112.9TERT, ESR1, LSL
18nomegestrol acetate459.9LSL, ESR1
19olanzapine50 45 29 11 2413.9LEP, INS, LSL
20metformin45 50 1111.8LSL, INS, LEP
21c-peptide459.8LSL, LEP, INS
22dhea459.8LSL, INS, LEP
23triacylglycerol459.8LSL, INS, LEP
24androstenedione45 2410.8LEP, LSL, INS
25uric acid45 2410.8LSL, INS, LEP
26corticosterone45 60 2411.8LSL, LEP, HSPA8
27datp29 2410.8POLD1, POLA1, POLE, REV3L
28dctp45 2410.8POLA1, POLE, POLD1, REV3L
29dgtp45 2410.8POLD1, POLE, REV3L, POLA1
30troglitazone45 29 60 1112.6LSL, LEP, INS, RB1
31methotrexate45 50 1111.6LSL, RB1, ESR1, LEP
32glycerol45 11 2411.6HSPA8, LSL, INS, LEP
33cisplatin45 50 60 1112.6REV3L, RB1, LEP, TERT, HSPA8
34gnrh459.6ESR1, LEP, LSL, INS
35estrone45 29 11 2412.5LSL, LEP, ESR1
36ly294002459.5INS, ESR1, RB1, TERT, LEP
37phosphoric acid45 2410.5POLA1, TERT, POLE, POLD1, REV3L
38pyrophosphate45 2410.5POLA1, POLD1, TERT, REV3L, POLE
39rapamycin459.5INS, LEP, TERT, RB1
40paraffin459.4PTCH1, TERT, LEP, RB1, HSPA8, ESR1
41p003459.3RB1, LSL, LEP
42progesterone45 60 29 11 2413.3LEP, LSL, HSPA8, RB1, ESR1
43phosphatidylinositol458.9RB1, INS, LEP, TERT, LSL, SH2D2A
44cholesterol45 29 11 2411.9INS, LSL, RB1, LEP, HSPA8
45testosterone45 60 11 2411.8HSPA8, LSL, RB1, INS, LEP, TERT
46estrogen458.8TERT, RB1, ESR1, HSPA8, LEP, INS
47vegf458.7ESR1, HSPA8, TERT, LEP, SH2D2A, RB1

GO Terms for genes affiliated with Skin Tag

Sources:
16Gene Ontology
See all sources

Cellular components related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Cul7-RING ubiquitin ligase complexGO:0314679.2CUL7, FBXW8
2nucleoplasmGO:0056548.5ESR1, TERT, EFTUD2, POLD1, POLE, POLA1

Biological processes related to Skin Tag according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1base-excision repair, gap-fillingGO:00628710.2POLD1, POLE
2regulation of mitotic cell cycleGO:00734610.0RB1, POLD1, PTCH1
3positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
4positive regulation of nitric-oxide synthase activityGO:0510009.9ESR1, INS
5negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.8RB1, PTCH1, ESR1
6DNA synthesis involved in DNA repairGO:0007319.8POLA1, POLE, POLD1
7translesion synthesisGO:0199859.8POLA1, POLD1, REV3L
8telomere maintenance via semi-conservative replicationGO:0322019.7POLD1, POLE, POLA1
9telomere maintenance via recombinationGO:0007229.7POLD1, POLE, POLA1
10S phase of mitotic cell cycleGO:0000849.6POLD1, POLA1
11nucleotide-excision repair, DNA gap fillingGO:0062979.6REV3L, POLD1, POLE, POLA1
12telomere maintenanceGO:0007239.5POLA1, POLE, POLD1, TERT
13positive regulation of dendrite morphogenesisGO:0507759.2CUL7, FBXW8

Molecular functions related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA-directed DNA polymerase activityGO:0038879.4REV3L, POLD1, POLE, POLA1
23-5 exonuclease activityGO:0084089.4POLA1, POLD1, REV3L
34 iron, 4 sulfur cluster bindingGO:0515399.4POLA1, POLE, POLD1, REV3L
4chromatin bindingGO:0036829.2ESR1, POLD1, POLE, POLA1
5nucleotide bindingGO:0001669.0REV3L, POLD1, POLE, POLA1
6protein bindingGO:0055155.1HSPA8, RB1, FBXW8, SH2D2A, POLA1, POLD1

Products for genes affiliated with Skin Tag

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Tag

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet