TAG
MCID: SKN023
MIFTS: 49

Skin Tag (TAG) malady

Skin diseases category

Summaries for Skin Tag

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 An acrochordon (plural acrochorda, and also known as a (cutaneous) skin tag, or fibroepithelial polyp,)... more...

MalaCards: Skin Tag, also known as fibroepithelial polyp of skin, is related to acanthosis nigricans and gestational diabetes. An important gene associated with Skin Tag is EFTUD2 (elongation factor Tu GTP binding domain containing 2), and among its related pathways are Adipogenesis and Peptide hormone metabolism. The compounds exenatide and pramlintide have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Aliases & Classifications for Skin Tag

About this section
Sources:
9Disease Ontology, 63UMLS, 46Novoseek, 59SNOMED-CT, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin tag 9 63
fibroepithelial polyp of skin 9
fibroepithelial polyp 9
cutaneous tag 9
soft fibroma 9
skin tag nos 9
skin tags 46
tag 9


External Ids:

Disease Ontology9 DOID:6873
NCIt41 C3337, C3374

Related Diseases for Skin Tag

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Skin Tag via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1acanthosis nigricans30.4LEP, INS
2gestational diabetes30.1LEP, INS
3infertility29.9INS, LEP, ESR1
4fibroepithelial polyp of the anus10.5
5vulva fibroepithelial polyp10.5
6fibroepithelial polyp of urethra10.4
7fibroma10.2
8cystitis cystica10.2
9ureteral obstruction10.2
10ureterocele10.2
11intussusception10.2
12fibrous histiocytoma10.2
13familial adenomatous polyposis10.2
14verrucous carcinoma10.2
15cystitis10.2
16endometriosis10.2
17hemangiopericytoma10.2
18histiocytoma10.2
19ileus10.2
20microcephaly10.2
21microphthalmia10.2
22cleft palate10.2
23mental retardation10.2
24insulin resistance10.2
25rabson-mendenhall syndrome10.1INS
26molluscum contagiosum10.1
27dermatofibrosarcoma10.1
28dermatofibrosarcoma protuberans10.1
29acquired generalized lipodystrophy10.1LEP
30ovarian disease10.1ESR1
31familial partial lipodystrophy10.0LEP, INS
32fetal macrosomia10.0LEP, INS
33congenital generalized lipodystrophy type 210.0LEP, INS
34anovulation10.0INS, LEP
35eating disorder10.0LEP, INS
36amenorrhea10.0LEP, INS
37growth hormone deficiency10.0LEP, INS
38morbid obesity10.0LEP, INS
39hypopituitarism10.0LEP, INS
40hyperandrogenism10.0INS, LEP
41lipodystrophy10.0LEP, INS
42prader-willi syndrome10.0INS, LEP
43acromegaly10.0LEP, INS
44atherosclerosis10.0LEP, INS
45hypogonadism10.0INS, LEP
46glucose intolerance10.0LEP, INS
47hyperthyroidism10.0INS, LEP
48primary hyperoxaluria10.0LEP, INS
49hypertriglyceridemia10.0LEP, INS
50polycystic ovary syndrome10.0INS, LEP

Graphical network of the top 20 diseases related to Skin Tag:



Diseases related to skin tag

Symptoms for Skin Tag

About this section

Drugs & Therapeutics for Skin Tag

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Tag

Drug clinical trials:

Search ClinicalTrials for Skin Tag

Search NIH Clinical Center for Skin Tag

Search CenterWatch for Skin Tag

Genetic Tests for Skin Tag

About this section

Anatomical Context for Skin Tag

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Skin Tag:

34
Skin, Colon

Animal Models for Skin Tag or affiliated genes

About this section
Sources:
38MGI
See all sources

Publications for Skin Tag

About this section
Sources:
53PubMed
See all sources

Articles related to Skin Tag:

(show all 39)
idTitleAuthorsYear
1
Anal atresia, coloboma, microphthalmia, and nasal skin tag in a female patient with 3.5a88Mb deletion of 3q26 encompassing SOX2. (23613260)
2013
2
Skin tag of the nipple with blister formation: Two case reports. (24127900)
2013
3
Association of acanthosis nigricans and skin tags with insulin resistance. (22481657)
2012
4
Skin tag (acrochordon) on labium majus in an infertile female. (22980625)
2012
5
An association of human papillomaviruses low risk and high risk subtypes with skin tag. (23493098)
2012
6
Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels. (22615504)
2012
7
Atypical lipomatous tumor/"well-differentiated liposarcoma" of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases. (21358383)
2011
8
Skin tags, leptin, metabolic syndrome and change of the life style. (21860156)
2011
9
Skin tag and acanthosis nigricans: do they have a predictive value for gestational diabetes mellitus? (21472660)
2011
10
Increased tissue leptin hormone level and mast cell count in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (20826994)
2010
11
Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? (19453787)
2010
12
A study of androgen and estrogen receptors alpha, beta in skin tags. (20418971)
2010
13
Anal skin tag: do not injure the elephants. (20463592)
2010
14
Mammary skin tag in a 2-year-old girl: a long-lasting adnexal polyp of neonatal skin? (19840327)
2009
15
Verruca plus acrochordon: an 'over the top' skin tag. (19747304)
2009
16
Mandibulofacial syndrome with growth and mental retardation, microcephaly, ear anomalies with skin tags, and cleft palate in a mother and her son: autosomal dominant or X-linked syndrome? (19921636)
2009
17
Serum leptin, atherogenic lipids and glucose levels in patients with skin tags. (20049263)
2009
18
Four limb syndactyly, constriction rings and skin tags; amniotic bands or disorganization-like syndrome. (18978653)
2008
19
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
20
Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. (18397315)
2008
21
Skin tag removal [corrected]. (18791098)
2008
22
Basal cell carcinoma in a skin tag. (18779117)
2008
23
Rhabdomyomatous mesenchymal hamartoma presenting as a skin tag in the sternoclavicular area. (18158576)
2007
24
Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. (17988334)
2007
25
Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. (16952203)
2006
26
'Myxopapillary' ependymal rest presenting as a pre-sacral skin tag. (15875743)
2005
27
Skin tag. (15604558)
2005
28
Marzouk skin tag two-stage urethroplasty for the repair of complex cases of hypospadias. (14678181)
2004
29
Eccrine nevus presenting as a perianal skin tag: a case report and review of the literature. (12142620)
2002
30
Blister on a skin tag. (12218240)
2002
31
Multiple congenital anomalies syndrome: growth and mental retardation, microcephaly, preauricular skin tags, cleft palate, camptodactyly, and distal limb anomalies. Report on two unrelated Brazilian patients. (10528252)
1999
32
A case of perineal schwannoma resembling a skin tag. (10554437)
1999
33
Hemifacial microsomia in a newborn with hypoplastic skin lesions, an eyelid skin tag, and microphthalmia: an unusual presentation of Delleman syndrome. (9823495)
1998
34
Guess what! Skin tag (acrochordon) on the labium majus. (10026017)
1998
35
Cutaneous pseudosarcomatous polyp--another variant of dermal lipoma or only an "ancient" skin tag? (9243368)
1997
36
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
37
A method for removing the acrochordon (skin tag). (2308255)
1990
38
The accessory tragus--no ordinary skin tag. (2646335)
1989
39
Cutaneous skin tag of the foot. (6822720)
1983

Variations for Skin Tag

About this section

Expression for genes affiliated with Skin Tag

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Skin Tag

Search GEO for disease gene expression data for Skin Tag.

Pathways for genes affiliated with Skin Tag

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 55R&D Systems, 61Thomson Reuters, 54QIAGEN, 13EMD Millipore, 31KEGG
See all sources

Pathways related to Skin Tag according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, LEP
2
Show member pathways
9.3INS, LEP
39.3INS, LEP
4
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.3INS, LEP
5
Show member pathways
9.3LEP, INS
69.3LEP, INS
7
Show member pathways
FOXA transcription factor networks39
9.1INS, ESR1
8
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
8.5INS, ESR1, LEP
9
Show member pathways
8.0ESR1, PTCH1, LEP, INS

Compounds for genes affiliated with Skin Tag

About this section
Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 52PharmGKB
See all sources

Compounds related to Skin Tag according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1exenatide46 1210.8LEP, INS
2pramlintide46 1210.8INS, LEP
3sibutramine46 1210.8INS, LEP
4beta-hydroxybutyrate469.8INS, LEP
5acipimox46 3010.7LEP, INS
6intralipid469.7INS, LEP
7nash469.7INS, LEP
8telmisartan46 30 1211.7INS, LEP
9cortisone46 2510.7INS, LEP
10orlistat46 62 1211.7LEP, INS
11thiazolidinedione469.7INS, LEP
128-isoprostane469.7LEP, INS
13aicar46 25 1211.7LEP, INS
14dehydroepiandrosterone sulfate469.7LEP, INS
15fenofibrate46 52 1211.7LEP, INS
16glibenclamide46 30 52 6212.7INS, LEP
17metformin46 52 1211.7LEP, INS
18c-peptide469.6LEP, INS
19olanzapine46 52 30 25 1213.6INS, LEP
20dhea469.6INS, LEP
21triacylglycerol469.6LEP, INS
22pioglitazone30 46 52 1212.6LEP, INS
23androstenedione46 2510.6INS, LEP
24desogestrel46 1210.6ESR1, INS
25uric acid46 2510.6LEP, INS
26clomiphene citrate469.5INS, ESR1
27rosiglitazone30 46 52 25 1213.5INS, LEP
28troglitazone46 30 62 1212.5LEP, INS
29megestrol acetate469.4ESR1, LEP
30tibolone469.4LEP, ESR1
31letrozole46 52 62 1212.4ESR1, LEP
32naloxone46 30 52 1212.4LEP, ESR1
33carbohydrates469.3LEP, INS
34acth469.3LEP, INS
35estrone46 30 25 1212.2ESR1, LEP
36thyroxine46 2510.2INS, LEP
37dihydrotestosterone46 30 25 1212.1ESR1, LEP
38glycerol46 25 1211.0LEP, INS
39gnrh468.9ESR1, LEP, INS
40ly294002468.9INS, LEP, ESR1
41paraffin468.9ESR1, PTCH1, LEP
42testosterone46 62 25 1211.8ESR1, LEP, INS
43estrogen468.6INS, LEP, ESR1

GO Terms for genes affiliated with Skin Tag

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Skin Tag according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localizationGO:0328809.6PTCH1, INS
2positive regulation of insulin receptor signaling pathwayGO:0466289.6LEP, INS
3positive regulation of MAPK cascadeGO:0434109.4INS, LEP
4positive regulation of nitric-oxide synthase activityGO:0510009.4ESR1, INS
5glucose homeostasisGO:0425939.3INS, PTCH1
6regulation of insulin secretionGO:0507969.3INS, LEP
7positive regulation of nitric oxide biosynthetic processGO:0454299.3INS, ESR1
8glucose metabolic processGO:0060069.3LEP, INS
9negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.3ESR1, PTCH1
10response to estradiolGO:0323559.2ESR1, PTCH1
11energy reserve metabolic processGO:0061129.0LEP, INS

Molecular functions related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3LEP, INS

Products for genes affiliated with Skin Tag

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Tag

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet