TAG
MCID: SKN023
MIFTS: 49

Skin Tag (TAG) malady

Skin diseases category
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Summaries for Skin Tag

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65Wikipedia, 33MalaCards
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Wikipedia:65 An acrochordon (plural acrochorda, and also known as a (cutaneous) skin tag, or fibroepithelial polyp,)... more...

MalaCards: Skin Tag, also known as fibroepithelial polyp of skin, is related to acanthosis nigricans and gestational diabetes. An important gene associated with Skin Tag is EFTUD2 (elongation factor Tu GTP binding domain containing 2), and among its related pathways are Adipogenesis and Peptide hormone metabolism. The compounds exenatide and pramlintide have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Aliases & Classifications for Skin Tag

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8Disease Ontology, 62UMLS, 45Novoseek, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin tag 8 62
fibroepithelial polyp of skin 8
fibroepithelial polyp 8
cutaneous tag 8
soft fibroma 8
skin tag nos 8
skin tags 45
tag 8


External Ids:

Disease Ontology8 DOID:6873
NCIt40 C3337, C3374

Related Diseases for Skin Tag

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Skin Tag via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1acanthosis nigricans30.4LEP, INS
2gestational diabetes30.1LEP, INS
3infertility29.9INS, LEP, ESR1
4fibroepithelial polyp of the anus10.5
5vulva fibroepithelial polyp10.5
6fibroepithelial polyp of urethra10.4
7fibroma10.2
8cystitis cystica10.2
9ureteral obstruction10.2
10ureterocele10.2
11intussusception10.2
12fibrous histiocytoma10.2
13familial adenomatous polyposis10.2
14verrucous carcinoma10.2
15cystitis10.2
16endometriosis10.2
17hemangiopericytoma10.2
18histiocytoma10.2
19ileus10.2
20microcephaly10.2
21microphthalmia10.2
22cleft palate10.2
23mental retardation10.2
24insulin resistance10.2
25rabson-mendenhall syndrome10.1INS
26molluscum contagiosum10.1
27dermatofibrosarcoma10.1
28dermatofibrosarcoma protuberans10.1
29acquired generalized lipodystrophy10.1LEP
30ovarian disease10.1ESR1
31familial partial lipodystrophy10.0LEP, INS
32fetal macrosomia10.0LEP, INS
33congenital generalized lipodystrophy type 210.0LEP, INS
34anovulation10.0INS, LEP
35eating disorder10.0LEP, INS
36amenorrhea10.0LEP, INS
37growth hormone deficiency10.0LEP, INS
38morbid obesity10.0LEP, INS
39hypopituitarism10.0LEP, INS
40hyperandrogenism10.0INS, LEP
41lipodystrophy10.0LEP, INS
42prader-willi syndrome10.0INS, LEP
43acromegaly10.0LEP, INS
44atherosclerosis10.0LEP, INS
45hypogonadism10.0INS, LEP
46glucose intolerance10.0LEP, INS
47hyperthyroidism10.0INS, LEP
48primary hyperoxaluria10.0LEP, INS
49hypertriglyceridemia10.0LEP, INS
50polycystic ovary syndrome10.0INS, LEP

Graphical network of the top 20 diseases related to Skin Tag:



Diseases related to skin tag

Symptoms for Skin Tag

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Drugs & Therapeutics for Skin Tag

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Skin Tag

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Anatomical Context for Skin Tag

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33MalaCards
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MalaCards organs/tissues related to Skin Tag:

33
Skin, Colon

Animal Models for Skin Tag or affiliated genes

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Sources:
37MGI
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Publications for Skin Tag

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52PubMed
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Articles related to Skin Tag:

(show all 39)
idTitleAuthorsYear
1
Anal atresia, coloboma, microphthalmia, and nasal skin tag in a female patient with 3.5a88Mb deletion of 3q26 encompassing SOX2. (23613260)
2013
2
Skin tag of the nipple with blister formation: Two case reports. (24127900)
2013
3
Association of acanthosis nigricans and skin tags with insulin resistance. (22481657)
2012
4
Skin tag (acrochordon) on labium majus in an infertile female. (22980625)
2012
5
An association of human papillomaviruses low risk and high risk subtypes with skin tag. (23493098)
2012
6
Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels. (22615504)
2012
7
Atypical lipomatous tumor/"well-differentiated liposarcoma" of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases. (21358383)
2011
8
Skin tags, leptin, metabolic syndrome and change of the life style. (21860156)
2011
9
Skin tag and acanthosis nigricans: do they have a predictive value for gestational diabetes mellitus? (21472660)
2011
10
Increased tissue leptin hormone level and mast cell count in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (20826994)
2010
11
Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? (19453787)
2010
12
A study of androgen and estrogen receptors alpha, beta in skin tags. (20418971)
2010
13
Anal skin tag: do not injure the elephants. (20463592)
2010
14
Mammary skin tag in a 2-year-old girl: a long-lasting adnexal polyp of neonatal skin? (19840327)
2009
15
Verruca plus acrochordon: an 'over the top' skin tag. (19747304)
2009
16
Mandibulofacial syndrome with growth and mental retardation, microcephaly, ear anomalies with skin tags, and cleft palate in a mother and her son: autosomal dominant or X-linked syndrome? (19921636)
2009
17
Serum leptin, atherogenic lipids and glucose levels in patients with skin tags. (20049263)
2009
18
Four limb syndactyly, constriction rings and skin tags; amniotic bands or disorganization-like syndrome. (18978653)
2008
19
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
20
Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. (18397315)
2008
21
Skin tag removal [corrected]. (18791098)
2008
22
Basal cell carcinoma in a skin tag. (18779117)
2008
23
Rhabdomyomatous mesenchymal hamartoma presenting as a skin tag in the sternoclavicular area. (18158576)
2007
24
Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. (17988334)
2007
25
Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. (16952203)
2006
26
'Myxopapillary' ependymal rest presenting as a pre-sacral skin tag. (15875743)
2005
27
Skin tag. (15604558)
2005
28
Marzouk skin tag two-stage urethroplasty for the repair of complex cases of hypospadias. (14678181)
2004
29
Eccrine nevus presenting as a perianal skin tag: a case report and review of the literature. (12142620)
2002
30
Blister on a skin tag. (12218240)
2002
31
Multiple congenital anomalies syndrome: growth and mental retardation, microcephaly, preauricular skin tags, cleft palate, camptodactyly, and distal limb anomalies. Report on two unrelated Brazilian patients. (10528252)
1999
32
A case of perineal schwannoma resembling a skin tag. (10554437)
1999
33
Hemifacial microsomia in a newborn with hypoplastic skin lesions, an eyelid skin tag, and microphthalmia: an unusual presentation of Delleman syndrome. (9823495)
1998
34
Guess what! Skin tag (acrochordon) on the labium majus. (10026017)
1998
35
Cutaneous pseudosarcomatous polyp--another variant of dermal lipoma or only an "ancient" skin tag? (9243368)
1997
36
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
37
A method for removing the acrochordon (skin tag). (2308255)
1990
38
The accessory tragus--no ordinary skin tag. (2646335)
1989
39
Cutaneous skin tag of the foot. (6822720)
1983

Variations for Skin Tag

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Expression for genes affiliated with Skin Tag

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Tag

Search GEO for disease gene expression data for Skin Tag.

Pathways for genes affiliated with Skin Tag

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 54R&D Systems, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore, 30KEGG
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Pathways related to Skin Tag according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3INS, LEP
2
Show member pathways
9.3INS, LEP
39.3INS, LEP
4
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.3INS, LEP
5
Show member pathways
9.3LEP, INS
69.3LEP, INS
7
Show member pathways
FOXA transcription factor networks38
9.1INS, ESR1
8
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
8.5INS, ESR1, LEP
9
Show member pathways
8.0ESR1, PTCH1, LEP, INS

Compounds for genes affiliated with Skin Tag

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45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Skin Tag according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1exenatide45 1110.8LEP, INS
2pramlintide45 1110.8INS, LEP
3sibutramine45 1110.8INS, LEP
4beta-hydroxybutyrate459.8INS, LEP
5acipimox45 2910.7LEP, INS
6intralipid459.7INS, LEP
7nash459.7INS, LEP
8telmisartan45 29 1111.7INS, LEP
9cortisone45 2410.7INS, LEP
10orlistat45 61 1111.7LEP, INS
11thiazolidinedione459.7INS, LEP
128-isoprostane459.7LEP, INS
13aicar45 24 1111.7LEP, INS
14dehydroepiandrosterone sulfate459.7LEP, INS
15fenofibrate45 51 1111.7LEP, INS
16glibenclamide45 29 51 6112.7INS, LEP
17metformin45 51 1111.7LEP, INS
18c-peptide459.6LEP, INS
19olanzapine45 51 29 24 1113.6INS, LEP
20dhea459.6INS, LEP
21triacylglycerol459.6LEP, INS
22pioglitazone29 45 51 1112.6LEP, INS
23androstenedione45 2410.6INS, LEP
24desogestrel45 1110.6ESR1, INS
25uric acid45 2410.6LEP, INS
26clomiphene citrate459.5INS, ESR1
27rosiglitazone29 45 51 24 1113.5INS, LEP
28troglitazone45 29 61 1112.5LEP, INS
29megestrol acetate459.4ESR1, LEP
30tibolone459.4LEP, ESR1
31letrozole45 51 61 1112.4ESR1, LEP
32naloxone45 29 51 1112.4LEP, ESR1
33carbohydrates459.3LEP, INS
34acth459.3LEP, INS
35estrone45 29 24 1112.2ESR1, LEP
36thyroxine45 2410.2INS, LEP
37dihydrotestosterone45 29 24 1112.1ESR1, LEP
38glycerol45 24 1111.0LEP, INS
39gnrh458.9ESR1, LEP, INS
40ly294002458.9INS, LEP, ESR1
41paraffin458.9ESR1, PTCH1, LEP
42testosterone45 61 24 1111.8ESR1, LEP, INS
43estrogen458.6INS, LEP, ESR1

GO Terms for genes affiliated with Skin Tag

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16Gene Ontology
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Biological processes related to Skin Tag according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localizationGO:0328809.6PTCH1, INS
2positive regulation of insulin receptor signaling pathwayGO:0466289.6LEP, INS
3positive regulation of MAPK cascadeGO:0434109.4INS, LEP
4positive regulation of nitric-oxide synthase activityGO:0510009.4ESR1, INS
5glucose homeostasisGO:0425939.3INS, PTCH1
6regulation of insulin secretionGO:0507969.3INS, LEP
7positive regulation of nitric oxide biosynthetic processGO:0454299.3INS, ESR1
8glucose metabolic processGO:0060069.3LEP, INS
9negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.3ESR1, PTCH1
10response to estradiolGO:0323559.2ESR1, PTCH1
11energy reserve metabolic processGO:0061129.0LEP, INS

Molecular functions related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3LEP, INS

Products for genes affiliated with Skin Tag

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Sources for Skin Tag

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet