TAG
MCID: SKN023
MIFTS: 50

Skin Tag (TAG) malady

Skin diseases category

Summaries for Skin Tag

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63Wikipedia, 32MalaCards
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Wikipedia:63 An acrochordon (plural acrochorda, and also known as a (cutaneous) skin tag, or fibroepithelial polyp,)... more...

MalaCards: Skin Tag, also known as fibroepithelial polyp of skin, is related to breast cancer and retinitis. An important gene associated with Skin Tag is PTCH1 (patched 1), and among its related pathways are DNA replication initiation and HTLV-I infection. The compounds purvalanol a and exenatide have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related mouse phenotypes are skeleton and tumorigenesis.

Aliases & Classifications for Skin Tag

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8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin tag 8 60
fibroepithelial polyp of skin 8
fibroepithelial polyp 8
cutaneous tag 8
skin tag nos 8
soft fibroma 8
skin tags 44
tag 8


External Ids:

Disease Ontology8 DOID:6873
NCIt39 C3374, C3337

Related Diseases for Skin Tag

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17GeneCards, 18GeneDecks
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Diseases related to Skin Tag via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.4TERT, PTCH1, HSPA8, RB1, ESR1
2retinitis30.2POLE, POLD1, REV3L, POLA1
3ovarian cancer30.2TERT, ESR1, RB1
4multiple sclerosis30.1LSL, SH2D2A, HSPA8
5adenocarcinoma30.1HSPA8, RB1, ESR1, TERT, PTCH1
6graves' disease30.0HSPA8
7type 2 diabetes mellitus30.0LEP, INS, LSL, HSPA8
8gestational diabetes29.9LSL, LEP, INS
9hepatitis29.9POLA1, POLE, REV3L, POLD1
10diabetes mellitus29.9LSL, INS, LEP
11infertility29.9LSL, INS, LEP, ESR1
12atherosclerosis29.9INS, LEP, LSL
13retinoblastoma29.9ESR1, TERT, RB1
14hepatocellular carcinoma29.9INS, TERT, PTCH1, RB1
15pancreatitis29.6INS
16colorectal cancer29.6HSPA8, TERT
17vaccinia29.6POLD1, POLE, POLA1, REV3L
18glucose intolerance29.6LSL, INS, LEP
19xeroderma pigmentosum29.6PTCH1, REV3L, POLD1, POLE, POLA1
20leukemia29.6RB1, TERT, HSPA8
21hepatitis b29.6REV3L, POLA1, POLE, POLD1, HSPA8, TERT
22vulva fibroepithelial polyp10.5
23fibroepithelial polyp of the anus10.5
24fibroepithelial polyp of urethra10.4
25prostatitis10.3
26prostate cancer10.2
27schizophrenia10.2
28acanthosis nigricans10.2
29hypertension10.2
30lung cancer10.2
31ureteral obstruction10.2
32cystitis cystica10.2
33fibrous histiocytoma10.2
34familial adenomatous polyposis10.2
35ureterocele10.2
36intussusception10.2
37verrucous carcinoma10.2
38cystitis10.2
39endometriosis10.2
40hemangiopericytoma10.2
41histiocytoma10.2
42squamous cell carcinoma10.2
43parkinson's disease10.1
44microcephaly10.1
45microphthalmia10.1
46cleft palate10.1
47obesity10.1
48thalassemia10.1
49molluscum contagiosum10.1
50dermatofibrosarcoma10.1

Graphical network of the top 20 diseases related to Skin Tag:



Diseases related to skin tag

Clinical Features for Skin Tag

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Drugs & Therapeutics for Skin Tag

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Skin Tag

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Anatomical Context for Skin Tag

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32MalaCards
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MalaCards organs/tissues related to Skin Tag:

32
Skin, Colon

Animal Models for Skin Tag or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Skin Tag:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.0RB1, CUL7, PTCH1
2MP:00020069.8PTCH1, TERT, REV3L, RB1
3MP:00053899.7PGK2, TERT, PTCH1
4MP:00053759.2ESR1, CUL7, LEP, INS, RB1
5MP:00107719.0RB1, POLE, POLD1, INS, PTCH1
6MP:00053978.0RB1, SH2D2A, POLE, POLD1, REV3L, INS
7MP:00053877.9RB1, SH2D2A, POLE, POLD1, REV3L, INS
8MP:00053807.9RB1, FBXW8, POLD1, REV3L, INS, LEP
9MP:00053857.8RB1, FBXW8, POLD1, REV3L, INS, LEP
10MP:00107687.1RB1, FBXW8, POLE, POLD1, REV3L, INS
11MP:00053846.6REV3L, POLD1, SH2D2A, FBXW8, RB1, INS

Publications for Skin Tag

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50PubMed
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Articles related to Skin Tag:

(show all 39)
idTitleAuthorsYear
1
Anal atresia, coloboma, microphthalmia, and nasal skin tag in a female patient with 3.5a88Mb deletion of 3q26 encompassing SOX2. (23613260)
2013
2
Skin tag of the nipple with blister formation: Two case reports. (24127900)
2013
3
Association of acanthosis nigricans and skin tags with insulin resistance. (22481657)
2012
4
Skin tag (acrochordon) on labium majus in an infertile female. (22980625)
2012
5
An association of human papillomaviruses low risk and high risk subtypes with skin tag. (23493098)
2012
6
Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levels. (22615504)
2012
7
Atypical lipomatous tumor/"well-differentiated liposarcoma" of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases. (21358383)
2011
8
Skin tags, leptin, metabolic syndrome and change of the life style. (21860156)
2011
9
Skin tag and acanthosis nigricans: do they have a predictive value for gestational diabetes mellitus? (21472660)
2011
10
Increased tissue leptin hormone level and mast cell count in skin tags: a possible role of adipoimmune in the growth of benign skin growths. (20826994)
2010
11
Is there any relation between serum insulin and insulin-like growth factor-I in non-diabetic patients with skin tag? (19453787)
2010
12
A study of androgen and estrogen receptors alpha, beta in skin tags. (20418971)
2010
13
Anal skin tag: do not injure the elephants. (20463592)
2010
14
Mammary skin tag in a 2-year-old girl: a long-lasting adnexal polyp of neonatal skin? (19840327)
2009
15
Verruca plus acrochordon: an 'over the top' skin tag. (19747304)
2009
16
Mandibulofacial syndrome with growth and mental retardation, microcephaly, ear anomalies with skin tags, and cleft palate in a mother and her son: autosomal dominant or X-linked syndrome? (19921636)
2009
17
Serum leptin, atherogenic lipids and glucose levels in patients with skin tags. (20049263)
2009
18
Four limb syndactyly, constriction rings and skin tags; amniotic bands or disorganization-like syndrome. (18978653)
2008
19
Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant. (18388784)
2008
20
Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. (18397315)
2008
21
Skin tag removal [corrected]. (18791098)
2008
22
Basal cell carcinoma in a skin tag. (18779117)
2008
23
Rhabdomyomatous mesenchymal hamartoma presenting as a skin tag in the sternoclavicular area. (18158576)
2007
24
Skin tag as a cutaneous marker for impaired carbohydrate metabolism: a case-control study. (17988334)
2007
25
Prenatal sonographic diagnosis of congenital perineal skin tag: case report and review of the literature. (16952203)
2006
26
'Myxopapillary' ependymal rest presenting as a pre-sacral skin tag. (15875743)
2005
27
Skin tag. (15604558)
2005
28
Marzouk skin tag two-stage urethroplasty for the repair of complex cases of hypospadias. (14678181)
2004
29
Eccrine nevus presenting as a perianal skin tag: a case report and review of the literature. (12142620)
2002
30
Blister on a skin tag. (12218240)
2002
31
Multiple congenital anomalies syndrome: growth and mental retardation, microcephaly, preauricular skin tags, cleft palate, camptodactyly, and distal limb anomalies. Report on two unrelated Brazilian patients. (10528252)
1999
32
A case of perineal schwannoma resembling a skin tag. (10554437)
1999
33
Hemifacial microsomia in a newborn with hypoplastic skin lesions, an eyelid skin tag, and microphthalmia: an unusual presentation of Delleman syndrome. (9823495)
1998
34
Guess what! Skin tag (acrochordon) on the labium majus. (10026017)
1998
35
Cutaneous pseudosarcomatous polyp--another variant of dermal lipoma or only an "ancient" skin tag? (9243368)
1997
36
Eruptive skin tags and keratoacanthomas in a patient with prolactinoma and colonic polyposis. (8075462)
1994
37
A method for removing the acrochordon (skin tag). (2308255)
1990
38
The accessory tragus--no ordinary skin tag. (2646335)
1989
39
Cutaneous skin tag of the foot. (6822720)
1983

Genetic Variations for Skin Tag

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Expression for genes affiliated with Skin Tag

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Tag

Search GEO for disease gene expression data for Skin Tag.

Pathways for genes affiliated with Skin Tag

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Skin Tag according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8POLA1, POLE
29.5TERT, POLD1, POLE, RB1
39.5POLD1, POLE, POLA1
4
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9.5POLD1, POLE, POLA1
5
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9.5RB1, POLE, POLD1, ESR1
6
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9.3POLA1, POLE, POLD1, TERT
7
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9.3POLA1, POLE, POLD1, TERT
8
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9.0RB1, POLA1, POLE, POLD1, TERT
9
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9.0HSPA8, RB1, POLA1, POLE, POLD1
10
Hide members
9.0TERT, INS, POLD1, POLE, POLA1

Compounds for genes affiliated with Skin Tag

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Skin Tag according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1purvalanol a44 59 1112.3RB1, POLD1
2exenatide44 1111.3LEP, INS
3goserelin44 28 1112.2LSL
4desogestrel44 1111.1INS, ESR1
5pramlintide44 1111.1INS, LEP
6Cladribine1110.0POLA1, POLE
7tibolone449.9LSL, LEP, ESR1
8sibutramine44 1110.9LSL, INS, LEP
9megestrol acetate449.9ESR1, LEP
10beta-hydroxybutyrate449.9LEP, INS, LSL
11acipimox44 2810.9LSL, INS, LEP
12intralipid449.9LSL, INS, LEP
13nash449.9LSL, INS, LEP
14adpribose449.9TERT, RB1, HSPA8
15orlistat44 59 1111.9LEP, INS, LSL
16dehydroepiandrosterone sulfate449.9LEP, INS, LSL
17raloxifene44 28 49 1112.9ESR1, TERT, LSL
18nomegestrol acetate449.9ESR1, LSL
19olanzapine49 44 28 11 2413.9LEP, INS, LSL
20metformin44 49 1111.8LSL, INS, LEP
21c-peptide449.8LEP, INS, LSL
22dhea449.8LSL, INS, LEP
23triacylglycerol449.8LEP, INS, LSL
24androstenedione44 2410.8LSL, INS, LEP
25uric acid44 2410.8LEP, INS, LSL
26corticosterone44 59 2411.8HSPA8, LSL, LEP
27datp28 2410.8REV3L, POLD1, POLE, POLA1
28dctp44 2410.8POLA1, POLE, POLD1, REV3L
29dgtp44 2410.8POLA1, POLE, POLD1, REV3L
30troglitazone44 28 59 1112.6LSL, RB1, INS, LEP
31methotrexate44 49 1111.6LSL, RB1, LEP, ESR1
32glycerol44 11 2411.6HSPA8, LSL, INS, LEP
33cisplatin44 49 59 1112.6HSPA8, RB1, REV3L, LEP, TERT
34gnrh449.6ESR1, LEP, INS, LSL
35estrone44 28 11 2412.5LSL, LEP, ESR1
36ly294002449.5RB1, INS, LEP, TERT, ESR1
37phosphoric acid44 2410.5POLA1, POLE, POLD1, REV3L, TERT
38pyrophosphate44 2410.5POLA1, POLE, POLD1, REV3L, TERT
39rapamycin449.5TERT, LEP, INS, RB1
40paraffin449.4HSPA8, RB1, LEP, TERT, PTCH1, ESR1
41p003449.3LEP, RB1, LSL
42progesterone44 59 28 11 2413.3HSPA8, LSL, RB1, LEP, ESR1
43phosphatidylinositol448.9LSL, RB1, SH2D2A, INS, LEP, TERT
44cholesterol44 28 11 2411.9HSPA8, LSL, RB1, INS, LEP
45testosterone44 59 11 2411.8HSPA8, LSL, RB1, INS, LEP, TERT
46estrogen448.8HSPA8, LSL, RB1, INS, LEP, TERT
47vegf448.7HSPA8, LSL, RB1, SH2D2A, LEP, TERT

GO Terms for genes affiliated with Skin Tag

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16Gene Ontology
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Cellular components related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Cul7-RING ubiquitin ligase complexGO:0314679.2CUL7, FBXW8
2nucleoplasmGO:0056548.5ESR1, TERT, EFTUD2, POLD1, POLE, POLA1

Biological processes related to Skin Tag according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1base-excision repair, gap-fillingGO:00628710.2POLD1, POLE
2regulation of mitotic cell cycleGO:00734610.0RB1, POLD1, PTCH1
3positive regulation of insulin receptor signaling pathwayGO:0466289.9LEP, INS
4positive regulation of nitric-oxide synthase activityGO:0510009.9ESR1, INS
5negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.8RB1, PTCH1, ESR1
6DNA synthesis involved in DNA repairGO:0007319.8POLA1, POLE, POLD1
7translesion synthesisGO:0199859.8POLA1, POLD1, REV3L
8telomere maintenance via semi-conservative replicationGO:0322019.7POLD1, POLE, POLA1
9telomere maintenance via recombinationGO:0007229.7POLD1, POLE, POLA1
10S phase of mitotic cell cycleGO:0000849.6POLD1, POLA1
11nucleotide-excision repair, DNA gap fillingGO:0062979.6REV3L, POLD1, POLE, POLA1
12telomere maintenanceGO:0007239.5POLA1, POLE, POLD1, TERT
13positive regulation of dendrite morphogenesisGO:0507759.2CUL7, FBXW8

Molecular functions related to Skin Tag according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA-directed DNA polymerase activityGO:0038879.4REV3L, POLD1, POLE, POLA1
23-5 exonuclease activityGO:0084089.4POLA1, POLD1, REV3L
34 iron, 4 sulfur cluster bindingGO:0515399.4POLA1, POLE, POLD1, REV3L
4chromatin bindingGO:0036829.2ESR1, POLD1, POLE, POLA1
5nucleotide bindingGO:0001669.0REV3L, POLD1, POLE, POLA1
6protein bindingGO:0055155.1HSPA8, RB1, FBXW8, SH2D2A, POLA1, POLD1

Products for genes affiliated with Skin Tag

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Sources for Skin Tag

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet