MCID: SLS001
MIFTS: 34

Sle Susceptibility malady

Summaries for Sle Susceptibility

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34MalaCards
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MalaCards: Sle Susceptibility is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Sle Susceptibility is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are LDL Oxidation in Atherogenesis and Staphylococcus aureus infection. The compounds hind iii and echinomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Sle Susceptibility

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48OMIM
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Aliases & Descriptions:

sle susceptibility 48


Related Diseases for Sle Susceptibility

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18GeneCards, 19GeneDecks
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Diseases related to Sle Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.7C4A, DNASE1
2systemic lupus erythematosus30.4BLK, TNF, STAT4, CCL2, DNASE1, CR1
3c7 deficiency10.1C7
4periapical granuloma10.1CCL2
5complement deficiency10.1CR1, C4A
6alcoholic hepatitis10.1TNF, CCL2
7interstitial lung disease10.1CCL2, TNF
8hereditary angioedema10.1C4B, CR1
9atherosclerosis10.1
10hypoxia10.1
11connective tissue disease10.0TNF, CCL2, DNASE1
12membranous glomerulonephritis10.0CR1, CCL2
13cork-handlers' disease10.0TNF, CCL2, DNASE1
14lupus nephritis10.0CCL2, DNASE1, CR1
15nephritis10.0CCL2, CR1, C4A
16renal fibrosis10.0CCL2, HIF1A
17tuberculosis10.0CR1, DNASE1, TNF
18congenital heart disease10.0CCL2, HIF1A, TNF
19peritonitis10.0CR1, CCL2, TNF
20fibrosarcoma10.0DNASE1, HIF1A, TNF
21pulmonary sarcoidosis10.0TNF, CCL2
22cerebral malaria10.0CR1, TNF
23sarcoidosis10.0CR1, CCL2, TNF
24arthritis10.0CR1, CCL2, TNF
25inflammatory bowel disease10.0CCL2, STAT4, HIF1A, TNF
26sepsis10.0TNF, CCL2, CR1, C4A
27encephalomyelitis10.0TNF, STAT4, CCL2, CR1
28pneumonia10.0CR1, CCL2, TNF
29diabetes mellitus10.0TNF, CCL2, IFIH1
30primary hyperoxaluria10.0C4B, C4A, CR1, DNASE1, CCL2
31multiple sclerosis10.0TNF, STAT4, CCL2, CR1, C4B
32asthma10.0TNF, STAT4, CCL2, DNASE1, CR1
33ipex syndrome9.9TNF, STAT4, CCL2, DNASE1, CR1, C4A
34rheumatoid arthritis9.9TNF, STAT4, IKBKE, CCL2, CR1
35influenza9.9IFIH1, DNASE1, CR1
36hypersensitivity reaction type ii disease9.9TNF, STAT4, CCL2, DNASE1, CR1, C4A
37viral infectious disease9.9CR1, IFIH1, CCL2, IKBKE, TNF
38melanoma9.8TNF, HIF1A, IKBKE, IFIH1, DNASE1, CR1

Graphical network of the top 20 diseases related to Sle Susceptibility:



Diseases related to sle susceptibility

Symptoms for Sle Susceptibility

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Drugs & Therapeutics for Sle Susceptibility

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Sle Susceptibility

Search CenterWatch for Sle Susceptibility

Genetic Tests for Sle Susceptibility

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Anatomical Context for Sle Susceptibility

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34MalaCards
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MalaCards organs/tissues related to Sle Susceptibility:

34
T cells

Animal Models for Sle Susceptibility or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Sle Susceptibility:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.7TNF, HIF1A, STAT4, CCL2, DNASE1, C4B
2MP:00053877.7C4B, BLK, TNF, HIF1A, STAT4, IKBKE

Publications for Sle Susceptibility

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53PubMed
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Articles related to Sle Susceptibility:

(show all 16)
idTitleAuthorsYear
1
Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice. (24395554)
2014
2
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. (24163247)
2013
3
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. (23874208)
2013
4
Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility. (23535865)
2013
5
Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population. (24232601)
2013
6
Complement components 2 and 7 (C2 and C7) gene polymorphisms are not major risk factors for SLE susceptibility in the Malaysian population. (21881993)
2012
7
Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility. (22707193)
2012
8
Meta-analysis of TNF-I+ promoter -308A/G polymorphism and SLE susceptibility in Asian populations. (20333386)
2011
9
Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility. (20166876)
2010
10
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. (19225526)
2009
11
Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. (17503323)
2007
12
APRIL polymorphism and systemic lupus erythematosus (SLE) susceptibility. (17569747)
2007
13
Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. (16418737)
2006
14
Association of a non-synonymous single-nucleotide polymorphism of DNASEI with SLE susceptibility. (16449364)
2006
15
Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3. (15014430)
2004
16
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. (8661718)
1996

Variations for Sle Susceptibility

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Expression for genes affiliated with Sle Susceptibility

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sle Susceptibility

Search GEO for disease gene expression data for Sle Susceptibility.

Pathways for genes affiliated with Sle Susceptibility

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51PathCards, 54QIAGEN, 31KEGG, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 5Cell Signaling Technology, 58SinoBiological
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Pathways related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL2, TNF
29.9C2, C4A, C4B
3
Show member pathways
9.8CR1, STAT4, TNF
49.7TNF, CCL2, CR1
5
Show member pathways
9.7C4A, C7, CR1, C2
6
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.6TNF, IKBKE, CCL2
79.6C4B, C4A, C2, TNF
89.6IFIH1, IKBKE, TNF
9
Show member pathways
9.6IFIH1, IKBKE, TNF
10
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.5C2, CR1, C7, C4A, C4B
11
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.5C4B, C4A, C7, CR1, C2
129.5C4B, C4A, HIF1A, TNF
13
Show member pathways
9.4BLK, TNF, STAT4, IKBKE
14
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.4TNF, STAT4, IKBKE, CCL2
15
Show member pathways
9.4C4B, C4A, C7, C2, TNF
16
Show member pathways
9.3TNF, IKBKE, CCL2, IFIH1
17
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0TNF, STAT4, IKBKE, CCL2, IFIH1

Compounds for genes affiliated with Sle Susceptibility

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46Novoseek, 62Tocris Bioscience, 25HMDB, 52PharmGKB, 30IUPHAR, 12DrugBank
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Compounds related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hind iii4610.3C4A, CR1
2echinomycin4610.3DNASE1, HIF1A
3n-tosyl-l-phenylalanine chloromethyl ketone4610.3CCL2, TNF
4actinomycin4610.3TNF, DNASE1
5toxin-14610.3TNF, CCL2
6mip 1alpha4610.3TNF, CCL2
7deta nonoate4610.2CCL2, HIF1A
8anaphylatoxin4610.2CCL2, CR1, C4A
9ro 31 82204610.2CCL2, TNF
10polymyxin b4610.1CR1, CCL2, TNF
11agarose4610.1DNASE1, C4A, C4B
12leukotriene b446 62 2512.1CR1, CCL2, TNF
13il-124610.1TNF, STAT4, CCL2
145 aminosalicylic acid4610.1CCL2, TNF
15aebsf4610.0HIF1A, TNF
16formaldehyde46 2511.0CCL2, DNASE1, CR1
17zymosan4610.0CR1, TNF
18diphenyleneiodonium4610.0TNF, HIF1A, CCL2
19pdtc4610.0TNF, HIF1A, CCL2
20endotoxin469.9C4A, CR1, CCL2, TNF
21sp 60012546 6210.9TNF, HIF1A, CCL2
22egcg469.9TNF, HIF1A, CCL2
23mg 13246 6210.9CCL2, HIF1A, TNF
24candesartan46 52 30 1212.9CCL2, HIF1A
25tpck469.8TNF, CCL2
26fmlp469.8CR1, CCL2, TNF
27paraffin469.8CR1, DNASE1, CCL2, HIF1A
28cyclosporin a46 30 6211.7CR1, DNASE1, HIF1A, TNF
29n acetylcysteine469.7DNASE1, CCL2, HIF1A, TNF
30actinomycin d469.7DNASE1, CCL2, HIF1A, TNF
31superoxide46 2510.6CR1, CCL2, HIF1A, TNF
32dexamethasone46 52 30 1212.5TNF, HIF1A, STAT4, CCL2, DNASE1
33oxygen46 2510.4TNF, HIF1A, CCL2, CR1, C4A
34phosphatidylinositol469.3BLK, HIF1A, STAT4, IKBKE, CCL2, CR1
35retinoic acid46 2510.2TNF, HIF1A, IFIH1, DNASE1, CR1
36cycloheximide469.1CR1, CCL2, HIF1A, TNF
37serine468.6C4B, TNF, HIF1A, C2, STAT4, IKBKE

GO Terms for genes affiliated with Sle Susceptibility

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17Gene Ontology
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Cellular components related to Sle Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9C4B, C4A, C7, DNASE1, CCL2, C2

Biological processes related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:05080610.1CCL2, TNF
2positive regulation of chemokine productionGO:03272210.0HIF1A, TNF
3JAK-STAT cascadeGO:00725910.0CCL2, STAT4
4protein kinase B signalingGO:0434919.9CCL2, TNF
5complement activationGO:0069569.9C2, C7, C4A, C4B
6lipopolysaccharide-mediated signaling pathwayGO:0316639.8CCL2, TNF
7regulation of complement activationGO:0304499.7C4B, C4A, C7, CR1, C2
8complement activation, classical pathwayGO:0069589.7C2, CR1, C7, C4A, C4B
9response to hypoxiaGO:0016669.6TNF, HIF1A, CCL2
10response to activityGO:0148239.6CCL2, TNF
11protein phosphorylationGO:0064689.3STAT4, IKBKE, CCL2, PXK
12inflammatory responseGO:0069549.2TNF, CCL2, PXK, C4A, C4B
13innate immune responseGO:0450879.1C2, IKBKE, IFIH1, CR1, C7, C4A

Products for genes affiliated with Sle Susceptibility

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Sources for Sle Susceptibility

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet