MCID: SLS001
MIFTS: 35

Sle Susceptibility malady

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Summaries for Sle Susceptibility

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MalaCards based summary: Sle Susceptibility is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Sle Susceptibility is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are LDL Oxidation in Atherogenesis and Staphylococcus aureus infection. The compounds hind iii and echinomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Sle Susceptibility

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Sle Susceptibility, Aliases & Descriptions:

Name: Sle Susceptibility 46


Related Diseases for Sle Susceptibility

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Diseases related to Sle Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus31.2DNASE1, C4A
2systemic lupus erythematosus29.9TNF, BLK, C4B, C4A, CR1, STAT4
3c7 deficiency10.5C7
4periapical granuloma10.4CCL2
5alcoholic hepatitis10.3CCL2, TNF
6complement deficiency10.3C4A, CR1
7interstitial lung disease10.3TNF, CCL2
8hereditary angioedema10.2C4B, CR1
9connective tissue disease10.2TNF, CCL2, DNASE1
10membranous glomerulonephritis10.2CCL2, CR1
11demyelinating disease10.1CCL2, TNF
12cork-handlers' disease10.1DNASE1, CCL2, TNF
13lupus nephritis10.1CR1, DNASE1, CCL2
14nephritis10.1C4A, CR1, CCL2
15renal fibrosis10.1HIF1A, CCL2
16tuberculosis10.1CR1, DNASE1, TNF
17cerebral malaria10.1TNF, CR1
18congenital heart disease10.1CCL2, TNF, HIF1A
19peritonitis10.1CR1, CCL2, TNF
20fibrosarcoma10.1HIF1A, DNASE1, TNF
21atherosclerosis10.1
22hypoxia10.1
23pulmonary sarcoidosis10.0CCL2, TNF
24sarcoidosis10.0CR1, TNF, CCL2
25arthritis10.0TNF, CCL2, CR1
26inflammatory bowel disease10.0CCL2, STAT4, HIF1A, TNF
27sepsis10.0C4A, CCL2, CR1, TNF
28pneumonia10.0CR1, CCL2, TNF
29diabetes mellitus9.9TNF, CCL2, IFIH1
30primary hyperoxaluria9.9CR1, C4B, CCL2, DNASE1, C4A
31multiple sclerosis9.9C4B, STAT4, TNF, CCL2, CR1
32asthma9.8TNF, CR1, STAT4, CCL2, DNASE1
33ipex syndrome9.8C4A, CR1, CCL2, STAT4, DNASE1, TNF
34influenza9.7CR1, DNASE1, IFIH1
35rheumatoid arthritis9.7CCL2, CR1, STAT4, TNF, IKBKE
36hypersensitivity reaction type ii disease9.7TNF, STAT4, CCL2, CR1, C4A, DNASE1
37viral infectious disease9.5IKBKE, TNF, CCL2, IFIH1, CR1
38melanoma9.3CR1, DNASE1, IFIH1, IKBKE, TNF, HIF1A

Graphical network of the top 20 diseases related to Sle Susceptibility:



Diseases related to sle susceptibility

Symptoms for Sle Susceptibility

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Drugs & Therapeutics for Sle Susceptibility

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Drug clinical trials:

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Search NIH Clinical Center for Sle Susceptibility

Genetic Tests for Sle Susceptibility

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Anatomical Context for Sle Susceptibility

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MalaCards organs/tissues related to Sle Susceptibility:

32
T cells

Animal Models for Sle Susceptibility or affiliated genes

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MGI Mouse Phenotypes related to Sle Susceptibility:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.7TNF, HIF1A, STAT4, CCL2, DNASE1, C4B
2MP:00053877.7C4B, BLK, TNF, HIF1A, STAT4, IKBKE

Publications for Sle Susceptibility

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Articles related to Sle Susceptibility:

(show all 17)
idTitleAuthorsYear
1
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. (24871463)
2014
2
Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice. (24395554)
2014
3
Evaluation of SLE Susceptibility Genes in Malaysians. (24696779)
2014
4
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. (24163247)
2013
5
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. (23874208)
2013
6
Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility. (23535865)
2013
7
Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population. (24232601)
2013
8
Complement components 2 and 7 (C2 and C7) gene polymorphisms are not major risk factors for SLE susceptibility in the Malaysian population. (21881993)
2012
9
Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility. (22707193)
2012
10
Meta-analysis of TNF-I+ promoter -308A/G polymorphism and SLE susceptibility in Asian populations. (20333386)
2011
11
Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility. (20166876)
2010
12
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. (19225526)
2009
13
Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. (17503323)
2007
14
APRIL polymorphism and systemic lupus erythematosus (SLE) susceptibility. (17569747)
2007
15
Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. (16418737)
2006
16
Association of a non-synonymous single-nucleotide polymorphism of DNASEI with SLE susceptibility. (16449364)
2006
17
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. (8661718)
1996

Variations for Sle Susceptibility

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Expression for genes affiliated with Sle Susceptibility

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Expression patterns in normal tissues for genes affiliated with Sle Susceptibility

Search GEO for disease gene expression data for Sle Susceptibility.

Pathways for genes affiliated with Sle Susceptibility

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Pathways related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL2, TNF
29.9C2, C4A, C4B
3
Show member pathways
9.8TNF, CR1, STAT4
49.7CCL2, TNF, CR1
5
Show member pathways
9.7C7, CR1, C2, C4A
6
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.6CCL2, TNF, IKBKE
79.6C4B, C4A, TNF, C2
8
Show member pathways
9.6TNF, IFIH1, IKBKE
99.6IKBKE, IFIH1, TNF
10
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.5CR1, C7, C4A, C4B, C2
11
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.5C4B, C4A, C7, CR1, C2
129.5C4A, HIF1A, TNF, C4B
13
Show member pathways
9.4STAT4, IKBKE, TNF, BLK
14
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4CCL2, IKBKE, STAT4, TNF
15
Show member pathways
9.4C2, C7, C4A, C4B, TNF
16
Show member pathways
9.3IFIH1, TNF, CCL2, IKBKE
17
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.0STAT4, CCL2, IFIH1, TNF, IKBKE

Compounds for genes affiliated with Sle Susceptibility

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Compounds related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hind iii4410.3C4A, CR1
2echinomycin4410.3DNASE1, HIF1A
3n-tosyl-l-phenylalanine chloromethyl ketone4410.3TNF, CCL2
4actinomycin4410.3DNASE1, TNF
5toxin-14410.3CCL2, TNF
6mip 1alpha4410.2TNF, CCL2
7deta nonoate4410.2HIF1A, CCL2
8anaphylatoxin4410.2C4A, CCL2, CR1
9ro 31 82204410.2CCL2, TNF
10polymyxin b4410.1TNF, CCL2, CR1
11agarose4410.1C4B, DNASE1, C4A
12leukotriene b444 61 2412.1TNF, CCL2, CR1
13il-124410.1STAT4, CCL2, TNF
145 aminosalicylic acid4410.1CCL2, TNF
15aebsf4410.0TNF, HIF1A
16formaldehyde44 2411.0CR1, CCL2, DNASE1
17zymosan4410.0CR1, TNF
18diphenyleneiodonium4410.0CCL2, HIF1A, TNF
19pdtc4410.0TNF, CCL2, HIF1A
20endotoxin449.9CR1, CCL2, TNF, C4A
21sp 60012544 6110.9TNF, HIF1A, CCL2
22egcg449.9TNF, CCL2, HIF1A
23mg 13244 6110.9CCL2, TNF, HIF1A
24candesartan44 50 28 1112.9CCL2, HIF1A
25tpck449.8CCL2, TNF
26fmlp449.8CCL2, TNF, CR1
27paraffin449.8DNASE1, CCL2, HIF1A, CR1
28cyclosporin a44 28 6111.7DNASE1, CR1, TNF, HIF1A
29n acetylcysteine449.7DNASE1, HIF1A, TNF, CCL2
30actinomycin d449.7HIF1A, CCL2, DNASE1, TNF
31superoxide44 2410.6CCL2, CR1, TNF, HIF1A
32dexamethasone44 50 28 1112.5CCL2, STAT4, TNF, HIF1A, DNASE1
33oxygen44 2410.4C4A, TNF, CCL2, CR1, HIF1A
34phosphatidylinositol449.3CR1, BLK, HIF1A, IKBKE, CCL2, STAT4
35retinoic acid44 2410.2HIF1A, IFIH1, TNF, CR1, DNASE1
36cycloheximide449.1TNF, HIF1A, CCL2, CR1
37serine448.6C2, TNF, HIF1A, STAT4, IKBKE, DNASE1

GO Terms for genes affiliated with Sle Susceptibility

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Cellular components related to Sle Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9C4B, C4A, C7, DNASE1, CCL2, C2

Biological processes related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:05080610.1CCL2, TNF
2positive regulation of chemokine productionGO:03272210.0HIF1A, TNF
3JAK-STAT cascadeGO:00725910.0STAT4, CCL2
4protein kinase B signalingGO:0434919.9TNF, CCL2
5complement activationGO:0069569.9C2, C7, C4A, C4B
6lipopolysaccharide-mediated signaling pathwayGO:0316639.8TNF, CCL2
7regulation of complement activationGO:0304499.7C4A, C4B, CR1, C2, C7
8complement activation, classical pathwayGO:0069589.7C4B, C7, CR1, C4A, C2
9response to hypoxiaGO:0016669.6CCL2, TNF, HIF1A
10response to activityGO:0148239.6CCL2, TNF
11protein phosphorylationGO:0064689.3STAT4, IKBKE, PXK, CCL2
12inflammatory responseGO:0069549.2C4B, C4A, PXK, TNF, CCL2
13innate immune responseGO:0450879.1C2, IKBKE, CR1, C4B, IFIH1, C7

Products for genes affiliated with Sle Susceptibility

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Sources for Sle Susceptibility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet