MCID: SLS001
MIFTS: 34

Sle Susceptibility malady

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Summaries for Sle Susceptibility

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33MalaCards
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MalaCards: Sle Susceptibility is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Sle Susceptibility is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are LDL Oxidation in Atherogenesis and Staphylococcus aureus infection. The compounds hind iii and echinomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Sle Susceptibility

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47OMIM
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Aliases & Descriptions:

sle susceptibility 47


Related Diseases for Sle Susceptibility

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17GeneCards, 18GeneDecks
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Diseases related to Sle Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.7C4A, DNASE1
2systemic lupus erythematosus30.4BLK, TNF, STAT4, CCL2, DNASE1, CR1
3c7 deficiency10.1C7
4periapical granuloma10.1CCL2
5complement deficiency10.1CR1, C4A
6alcoholic hepatitis10.1TNF, CCL2
7interstitial lung disease10.1CCL2, TNF
8hereditary angioedema10.1C4B, CR1
9atherosclerosis10.1
10hypoxia10.1
11connective tissue disease10.0TNF, CCL2, DNASE1
12membranous glomerulonephritis10.0CR1, CCL2
13cork-handlers' disease10.0TNF, CCL2, DNASE1
14lupus nephritis10.0CCL2, DNASE1, CR1
15nephritis10.0CCL2, CR1, C4A
16renal fibrosis10.0CCL2, HIF1A
17tuberculosis10.0CR1, DNASE1, TNF
18congenital heart disease10.0CCL2, HIF1A, TNF
19peritonitis10.0CR1, CCL2, TNF
20fibrosarcoma10.0DNASE1, HIF1A, TNF
21pulmonary sarcoidosis10.0TNF, CCL2
22cerebral malaria10.0CR1, TNF
23sarcoidosis10.0CR1, CCL2, TNF
24arthritis10.0CR1, CCL2, TNF
25inflammatory bowel disease10.0CCL2, STAT4, HIF1A, TNF
26sepsis10.0TNF, CCL2, CR1, C4A
27encephalomyelitis10.0TNF, STAT4, CCL2, CR1
28pneumonia10.0CR1, CCL2, TNF
29diabetes mellitus10.0TNF, CCL2, IFIH1
30primary hyperoxaluria10.0C4B, C4A, CR1, DNASE1, CCL2
31multiple sclerosis10.0TNF, STAT4, CCL2, CR1, C4B
32asthma10.0TNF, STAT4, CCL2, DNASE1, CR1
33ipex syndrome9.9TNF, STAT4, CCL2, DNASE1, CR1, C4A
34rheumatoid arthritis9.9TNF, STAT4, IKBKE, CCL2, CR1
35influenza9.9IFIH1, DNASE1, CR1
36hypersensitivity reaction type ii disease9.9TNF, STAT4, CCL2, DNASE1, CR1, C4A
37viral infectious disease9.9CR1, IFIH1, CCL2, IKBKE, TNF
38melanoma9.8TNF, HIF1A, IKBKE, IFIH1, DNASE1, CR1

Graphical network of the top 20 diseases related to Sle Susceptibility:



Diseases related to sle susceptibility

Symptoms for Sle Susceptibility

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Drugs & Therapeutics for Sle Susceptibility

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Sle Susceptibility

Search NIH Clinical Center for Sle Susceptibility

Genetic Tests for Sle Susceptibility

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Anatomical Context for Sle Susceptibility

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33MalaCards
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MalaCards organs/tissues related to Sle Susceptibility:

33
T cells

Animal Models for Sle Susceptibility or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sle Susceptibility:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.7TNF, HIF1A, STAT4, CCL2, DNASE1, C4B
2MP:00053877.7C4B, BLK, TNF, HIF1A, STAT4, IKBKE

Publications for Sle Susceptibility

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52PubMed
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Articles related to Sle Susceptibility:

(show all 16)
idTitleAuthorsYear
1
Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice. (24395554)
2014
2
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. (24163247)
2013
3
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. (23874208)
2013
4
Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility. (23535865)
2013
5
Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population. (24232601)
2013
6
Complement components 2 and 7 (C2 and C7) gene polymorphisms are not major risk factors for SLE susceptibility in the Malaysian population. (21881993)
2012
7
Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility. (22707193)
2012
8
Meta-analysis of TNF-I+ promoter -308A/G polymorphism and SLE susceptibility in Asian populations. (20333386)
2011
9
Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility. (20166876)
2010
10
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. (19225526)
2009
11
Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. (17503323)
2007
12
APRIL polymorphism and systemic lupus erythematosus (SLE) susceptibility. (17569747)
2007
13
Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. (16418737)
2006
14
Association of a non-synonymous single-nucleotide polymorphism of DNASEI with SLE susceptibility. (16449364)
2006
15
Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3. (15014430)
2004
16
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. (8661718)
1996

Variations for Sle Susceptibility

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Expression for genes affiliated with Sle Susceptibility

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sle Susceptibility

Search GEO for disease gene expression data for Sle Susceptibility.

Pathways for genes affiliated with Sle Susceptibility

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50PathCards, 53QIAGEN, 30KEGG, 55Reactome, 60Thomson Reuters, 38NCBI BioSystems Database, 5Cell Signaling Technology, 57SinoBiological
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Pathways related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL2, TNF
29.9C2, C4A, C4B
3
Show member pathways
9.8CR1, STAT4, TNF
49.7TNF, CCL2, CR1
5
Show member pathways
9.7C4A, C7, CR1, C2
6
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.6TNF, IKBKE, CCL2
79.6C4B, C4A, C2, TNF
89.6IFIH1, IKBKE, TNF
9
Show member pathways
9.6IFIH1, IKBKE, TNF
10
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.5C2, CR1, C7, C4A, C4B
11
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.5C4B, C4A, C7, CR1, C2
129.5C4B, C4A, HIF1A, TNF
13
Show member pathways
9.4BLK, TNF, STAT4, IKBKE
14
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4TNF, STAT4, IKBKE, CCL2
15
Show member pathways
9.4C4B, C4A, C7, C2, TNF
16
Show member pathways
9.3TNF, IKBKE, CCL2, IFIH1
17
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0TNF, STAT4, IKBKE, CCL2, IFIH1

Compounds for genes affiliated with Sle Susceptibility

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45Novoseek, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 29IUPHAR, 11DrugBank
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Compounds related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1hind iii4510.3C4A, CR1
2echinomycin4510.3DNASE1, HIF1A
3n-tosyl-l-phenylalanine chloromethyl ketone4510.3CCL2, TNF
4actinomycin4510.3TNF, DNASE1
5toxin-14510.3TNF, CCL2
6mip 1alpha4510.3TNF, CCL2
7deta nonoate4510.2CCL2, HIF1A
8anaphylatoxin4510.2CCL2, CR1, C4A
9ro 31 82204510.2CCL2, TNF
10polymyxin b4510.1CR1, CCL2, TNF
11agarose4510.1DNASE1, C4A, C4B
12leukotriene b445 61 2412.1CR1, CCL2, TNF
13il-124510.1TNF, STAT4, CCL2
145 aminosalicylic acid4510.1CCL2, TNF
15aebsf4510.0HIF1A, TNF
16formaldehyde45 2411.0CCL2, DNASE1, CR1
17zymosan4510.0CR1, TNF
18diphenyleneiodonium4510.0TNF, HIF1A, CCL2
19pdtc4510.0TNF, HIF1A, CCL2
20endotoxin459.9C4A, CR1, CCL2, TNF
21sp 60012545 6110.9TNF, HIF1A, CCL2
22egcg459.9TNF, HIF1A, CCL2
23mg 13245 6110.9CCL2, HIF1A, TNF
24candesartan45 51 29 1112.9CCL2, HIF1A
25tpck459.8TNF, CCL2
26fmlp459.8CR1, CCL2, TNF
27paraffin459.8CR1, DNASE1, CCL2, HIF1A
28cyclosporin a45 29 6111.7CR1, DNASE1, HIF1A, TNF
29n acetylcysteine459.7DNASE1, CCL2, HIF1A, TNF
30actinomycin d459.7DNASE1, CCL2, HIF1A, TNF
31superoxide45 2410.6CR1, CCL2, HIF1A, TNF
32dexamethasone45 51 29 1112.5TNF, HIF1A, STAT4, CCL2, DNASE1
33oxygen45 2410.4TNF, HIF1A, CCL2, CR1, C4A
34phosphatidylinositol459.3BLK, HIF1A, STAT4, IKBKE, CCL2, CR1
35retinoic acid45 2410.2TNF, HIF1A, IFIH1, DNASE1, CR1
36cycloheximide459.1CR1, CCL2, HIF1A, TNF
37serine458.6C4B, TNF, HIF1A, C2, STAT4, IKBKE

GO Terms for genes affiliated with Sle Susceptibility

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16Gene Ontology
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Cellular components related to Sle Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9C4B, C4A, C7, DNASE1, CCL2, C2

Biological processes related to Sle Susceptibility according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of synaptic transmissionGO:05080610.1CCL2, TNF
2positive regulation of chemokine productionGO:03272210.0HIF1A, TNF
3JAK-STAT cascadeGO:00725910.0CCL2, STAT4
4protein kinase B signalingGO:0434919.9CCL2, TNF
5complement activationGO:0069569.9C2, C7, C4A, C4B
6lipopolysaccharide-mediated signaling pathwayGO:0316639.8CCL2, TNF
7regulation of complement activationGO:0304499.7C4B, C4A, C7, CR1, C2
8complement activation, classical pathwayGO:0069589.7C2, CR1, C7, C4A, C4B
9response to hypoxiaGO:0016669.6TNF, HIF1A, CCL2
10response to activityGO:0148239.6CCL2, TNF
11protein phosphorylationGO:0064689.3STAT4, IKBKE, CCL2, PXK
12inflammatory responseGO:0069549.2TNF, CCL2, PXK, C4A, C4B
13innate immune responseGO:0450879.1C2, IKBKE, IFIH1, CR1, C7, C4A

Products for genes affiliated with Sle Susceptibility

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Sources for Sle Susceptibility

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet