MCID: SLP006
MIFTS: 59

Sleep Apnea malady

Neuronal diseases, Mental diseases categories
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Summaries for Sleep Apnea

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8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

MalaCards: Sleep Apnea, also known as sleep apnea syndromes, is related to obstructive sleep apnea and central sleep apnea. An important gene associated with Sleep Apnea is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds rimonabant and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and tonsil, and related mouse phenotypes are adipose tissue and respiratory system.

Disease Ontology:8 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

NINDS:44 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.

Wikipedia:65 Sleep apnea (or sleep apnoea in British English; / more...

Aliases & Classifications for Sleep Apnea

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8Disease Ontology, 44NINDS, 34MedlinePlus, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Mental diseases


Aliases & Descriptions:

sleep apnea 8 44 34
sleep apnea syndromes 62


External Ids:

Disease Ontology8 DOID:0050847
ICD1025 G47.3

Related Diseases for Sleep Apnea

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17GeneCards, 18GeneDecks
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Diseases in the Central Sleep Apnea family:

sleep apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 307)
idRelated DiseaseScoreTop Affiliating Genes
1obstructive sleep apnea32.2HCRT, LEP, HSPA1A, ADIPOQ, HTR2A, AGT
2central sleep apnea31.9KCNK9, KCNK3, NPPB
3obesity31.3HCRT, LEP, ADIPOQ, HTR2A, NOS3, AGT
4hypertension31.3LEP, NOS3, NPPA, NPPB, AGT
5congestive heart failure31.1NPPA, NPPB, AGT
6narcolepsy31.1HTR2A, LEP, HCRT
7insulin resistance30.8LEP, HSPA1A, ADIPOQ, HTR2A, NOS3, AGT
8hypothyroidism30.7LEP, ADIPOQ
9prader-willi syndrome30.6HCRT, LEP, ADIPOQ
10morbid obesity30.6LEP
11coronary artery disease30.5AGT, NPPB, NPPA, NOS3
12lipodystrophy30.5ADIPOQ, LEP
13cor pulmonale30.4NPPB, NPPA
14diabetes mellitus30.4LEP, ADIPOQ, NOS3, NPPA, NPPB, AGT
15type 2 diabetes mellitus30.4LEP, ADIPOQ, HTR2A, NOS3, AGT
16cerebrovascular disease30.4AGT, NPPB, NPPA, NOS3, HTR2A
17ischemia30.3HCRT, HSPA1A, NOS3, NPPB, AGT
18myocardial infarction30.3ADIPOQ, HTR2A, NOS3, NPPA, NPPB, AGT
19alzheimer's disease30.2HCRT, HSPA1A, HTR2A, NOS3
20primary pulmonary hypertension30.2NPPA, NPPB
21growth hormone deficiency30.2LEP, ADIPOQ
22gestational diabetes30.2LEP, ADIPOQ
23idiopathic edema30.2NPPB, NPPA, ADIPOQ
24mood disorder30.1NOS3, HTR2A, HCRT
25noonan syndrome30.1AGT, NPPB, NPPA
26uremia30.1LEP, ADIPOQ, NOS3
27acute myocardial infarction30.1HTR2A, NPPA, NPPB, AGT
28proteinuria30.1AGT, NOS3, ADIPOQ
29vascular disease30.1ADIPOQ, HTR2A, NOS3, AGT
30diabetic nephropathy30.1ADIPOQ, NOS3, NPPA, AGT
31atherosclerosis30.1AGT, NOS3, ADIPOQ, LEP
32essential hypertension29.8AGT, NPPB, NPPA, NOS3, HTR2A, ADIPOQ
33hypersomnia10.7
34endotheliitis10.7
35sleep disorder10.6
36hypoxia10.6
37pharyngitis10.6
38neuropathy10.6
39insomnia10.6
40achondroplasia10.6
41laryngomalacia10.6
42craniosynostosis10.5
43acromegaly10.5
44cerebritis10.5
45headache10.5
46patent foramen ovale10.4
47treacher collins syndrome10.4
48periodic limb movement disorder10.4
49systolic heart failure10.4
50rem sleep behavior disorder10.4

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to sleep apnea

Symptoms for Sleep Apnea

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Drugs & Therapeutics for Sleep Apnea

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Sleep Apnea

Search NIH Clinical Center for Sleep Apnea

Genetic Tests for Sleep Apnea

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Anatomical Context for Sleep Apnea

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33MalaCards
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MalaCards organs/tissues related to Sleep Apnea:

33
Heart, Lung, Tonsil, Endothelial, Brain, Testes, Bone, Liver, Ovary, Kidney, Eye, Monocytes, T cells, Bone marrow, Skin, Breast, Thyroid, Adipocyte, Whole blood, Tongue

Animal Models for Sleep Apnea or affiliated genes

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37MGI
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Publications for Sleep Apnea

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52PubMed
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Articles related to Sleep Apnea:

(show top 50)    (show all 1236)
idTitleAuthorsYear
1
Functional Comorbidity Index in Sleep Apnea. (24395621)
2014
2
Association of glucose transporter 4 genetic Polymorphisms with obstructive sleep apnea syndrome in Han Chinese general population: a cross-section study. (24410986)
2014
3
Assessment of the effect of bariatric surgery on obstructive sleep apnea at two postoperative intervals. (23856989)
2014
4
The evaluation of body composition, adiponectin, C-reactive protein and cholesterol levels in patients with obstructive sleep apnea syndrome. (24431310)
2013
5
Lipopolysaccharide-Binding Protein Plasma Levels in Children: Effects of Obstructive Sleep Apnea and Obesity. (24276451)
2013
6
Positive airway pressure therapy in patients with opioid-related central sleep apnea. (24062011)
2013
7
Letter regarding the review by Zhang et al. of portable recording for the diagnosis of obstructive sleep apnea in commercial motor vehicle drivers. (23904687)
2013
8
Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. (22974765)
2013
9
Obstructive sleep apnea as a risk factor after shoulder arthroplasty. (24045126)
2013
10
Executive dysfunction in children affected by obstructive sleep apnea syndrome: an observational study. (23976855)
2013
11
Effect of Qingxuan Granule () on blood pressure variability of hypertensive patients with and without obstructive sleep apnea. (24126974)
2013
12
Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. (22924163)
2013
13
Automated detection of sleep apnea in infants using minimally invasive sensors. (24110021)
2013
14
Obstructive sleep apnea (OSA) in preadolescent girls is associated with delayed breast development compared to girls without OSA. (23946712)
2013
15
Palatal sensory threshold reflects nocturnal hypoxemia and airway occlusion in snorers and obstructive sleep apnea patients. (24235900)
2013
16
Effectiveness of three sleep apnea management alternatives. (24293754)
2013
17
Motivational enhancement to improve adherence to positive airway pressure in patients with obstructive sleep apnea: a randomized controlled trial. (24179298)
2013
18
Effect of sleep apnea and continuous positive airway pressure on cardiac structure and recurrence of atrial fibrillation. (24275628)
2013
19
Obstructive sleep apnea does not promote esophageal reflux in fibrosing interstitial lung disease. (22521226)
2012
20
Late-onset laryngomalacia: a cause of pediatric obstructive sleep apnea. (21115204)
2011
21
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
22
Obstructive sleep apnea among patients with retinal vein occlusion. (21149775)
2010
23
Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome]. (20367952)
2010
24
Central sleep apnea. (20488284)
2010
25
Patent foramen ovale and obstructive sleep apnea: a new association? (20451427)
2010
26
Risk factors for obstructive sleep apnea syndrome screening in mood disorder patients. (19566771)
2009
27
Validity and reliability of Sleep Quality Scale in subjects with obstructive sleep apnea syndrome. (19073298)
2009
28
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
29
Idiopathic intracranial hypertension in men and the relationship to sleep apnea. (18923134)
2009
30
Role of continuous positive airway pressure therapy on the pathogenesis of sleep-related frontal lobe epilepsy in a child with obstructive sleep apnea syndrome. (18079319)
2008
31
Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP). (18780208)
2008
32
Increased low-grade inflammation and plasminogen-activator inhibitor-1 level in nondippers with sleep apnea syndrome. (18475156)
2008
33
Serum angiotensin converting enzyme and the obstructive sleep apnea hypopnea syndrome. (18763423)
2008
34
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
35
Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. (17667845)
2007
36
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
37
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. (16839844)
2006
38
Effects of nasal continuous positive airway pressure short-term treatment on C-reactive protein and intercellular adhesion molecule-1 in patients with obstructive sleep apnea-hypopnea syndrome]. (16708805)
2005
39
Glucocorticoid receptor subunit expression in adenotonsillar tissue of children with obstructive sleep apnea. (15611350)
2005
40
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
41
Idiopathic edema is associated with obstructive sleep apnea in women. (15511705)
2004
42
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
43
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
44
Obstructive sleep apnea in children with achondroplasia: surgical and anesthetic considerations. (9949360)
1999
45
Central sleep apnea after interrupting longterm acetazolamide therapy. (9696283)
1998
46
Continuous versus bilevel positive airway pressure in a patient with idiopathic central sleep apnea. (9105099)
1997
47
Relationship of nasal continuous positive airway pressure to periodic limb movement disorder in a patient without sleep apnea. (8486056)
1993
48
Nasal continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea in Hallermann-Streiff syndrome. (2406080)
1990
49
Achondroplasia and obstructive sleep apnea: correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy. (4041579)
1985
50
Achondroplasia associated with obstructive sleep apnea. (6625996)
1983

Variations for Sleep Apnea

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Expression for genes affiliated with Sleep Apnea

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for genes affiliated with Sleep Apnea

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Sources:
50PathCards, 53QIAGEN, 51PharmGKB, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Sleep Apnea according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NPPB, NPPA
2
Show member pathways
9.5NOS3, AGT
3
Show member pathways
9.5HCRT, HTR2A, AGT
4
Show member pathways
9.4NOS3, KCNMB1
59.4AGT, ADIPOQ, LEP
6
Show member pathways
9.4AGT, ADIPOQ, LEP
79.4NPPA, NPPB, AGT
8
Show member pathways
9.3NOS3, HSPA1A
9
Show member pathways
9.3AGT, HTR2A, LEP, HCRT
10
Show member pathways
9.2KCNMB1, KCNK3, KCNK9
11
Show member pathways
9.1HSPA1A, KCNK3, KCNK9
12
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.7NPPB, NOS3, HTR2A, HSPA1A

Compounds for genes affiliated with Sleep Apnea

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1rimonabant45 29 1111.9HCRT, ADIPOQ, LEP
2oxyntomodulin45 6110.8ADIPOQ, LEP, HCRT
3hanp459.8NPPB, NPPA, ADIPOQ
4ramipril45 1110.8NPPB, NPPA, ADIPOQ
5enalaprilat459.8NPPA, AGT, NPPB
6lisinopril45 51 24 1112.7AGT, NPPA, NPPB
78-bromo cgmp459.7NPPB, AGT, NPPA
8atenolol45 51 29 24 1113.7NPPB, LEP, AGT
9valsartan45 61 29 1112.7ADIPOQ, AGT, NPPB
10c-peptide459.5HCRT, LEP, ADIPOQ, AGT
11telmisartan45 29 1111.5AGT, NPPB, ADIPOQ, LEP
12n(g)-nitro-l-arginine methyl ester459.5AGT, NOS3, LEP
13enalapril45 51 1111.4AGT, NPPA, ADIPOQ, NPPB
14metoprolol45 51 29 24 1113.3NPPB, ADIPOQ, NPPA, NOS3
15aminoguanidine45 29 1111.3NOS3, HSPA1A, LEP
16pravastatin45 51 29 24 1113.3NPPB, ADIPOQ, LEP, NOS3
17perindopril45 51 1111.3AGT, NOS3, NPPA, NPPB
18haloperidol45 51 29 3 1113.3AGT, NPPB, HTR2A, HCRT, NPPA
19ang ii459.3NPPA, NOS3, AGT, NPPB
20candesartan45 51 29 1112.2AGT, NOS3, ADIPOQ, NPPB
21ng-nitro-l-arginine459.2NOS3, AGT, NPPA
22losartan45 51 29 1112.2AGT, LEP, ADIPOQ, NPPA, NPPB
23guanylate459.2NPPB, NPPA, NOS3, AGT
24homocysteine45 2410.1NPPB, AGT, NOS3, ADIPOQ
25rosiglitazone29 45 51 24 1113.1NPPB, ADIPOQ, LEP, NOS3
26sodium nitroprusside459.1NPPA, LEP, ADIPOQ, NOS3, NPPB
27l-nmma459.1LEP, NOS3, NPPA, NPPB, AGT
28atorvastatin45 51 29 24 1113.0ADIPOQ, NOS3, NPPB, AGT
29nifedipine45 29 51 1112.0LEP, ADIPOQ, NPPA, AGT
30amlodipine45 51 24 1112.0AGT, NPPA, NPPB, NOS3, ADIPOQ
31estradiol45 24 1110.9ADIPOQ, HCRT, AGT, NPPB, LEP
32dopamine45 29 24 1111.9HCRT, ADIPOQ, NPPA, NPPB, AGT, HTR2A
33phenylephrine45 29 24 1111.8NPPA, NOS3, LEP, HCRT, AGT, NPPB
348-isoprostane458.8LEP, NPPB, NOS3, ADIPOQ, HSPA1A
35thapsigargin45 619.8NOS3, ADIPOQ, HSPA1A, HCRT, NPPB
36acetylcholine45 51 29 24 1112.7NPPB, ADIPOQ, HCRT, LEP, AGT, NOS3
37epinephrine45 24 1110.7AGT, NPPB, NPPA, HSPA1A, LEP, HCRT
38prostacyclin458.7LEP, ADIPOQ, NOS3, NPPA, AGT, NPPB
39sb 20358045 619.6ADIPOQ, HSPA1A, NOS3, NPPB, AGT
40dexamethasone45 51 29 1111.5HSPA1A, HCRT, AGT, NPPB, ADIPOQ, LEP
41creatinine458.5LEP, AGT, NPPB, NPPA, ADIPOQ, HSPA1A
42cyclosporin a45 29 6110.5LEP, NPPA, NPPB, AGT, HSPA1A
43actinomycin d458.5AGT, HSPA1A, ADIPOQ, NOS3, NPPB
44estrogen458.1NPPB, HCRT, NPPA, NOS3, ADIPOQ, HSPA1A
45nitric oxide45 24 1110.1AGT, NPPB, NPPA, NOS3, HSPA1A, HCRT
46norepinephrine45 24 1110.1HTR2A, NPPA, NPPB, AGT, HSPA1A, ADIPOQ
47potassium45 24 1110.0NPPA, AGT, HSPA1A, HCRT, KCNK9, KCNMB1
48glutamate458.0ADIPOQ, LEP, KCNK3, HCRT, NOS3, KCNK9
49arginine457.7KCNK3, NOS3, ADIPOQ, HSPA1A, LEP, NPPA
50calcium45 51 24 1110.1AGT, HSPA1A, KCNK9, KCNMB1, HTR2A, NOS3

GO Terms for genes affiliated with Sleep Apnea

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Sources:
16Gene Ontology
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Cellular components related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8AGT, NPPB, NPPA, ADIPOQ, LEP
2extracellular regionGO:0055768.2AGT, HCRT, LEP, ADIPOQ, NPPA, NPPB

Biological processes related to Sleep Apnea according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.1NPPB, NPPA
2artery smooth muscle contractionGO:01482410.1HTR2A, AGT
3receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
4ovulation from ovarian follicleGO:00154210.0LEP, NOS3
5eating behaviorGO:04275510.0LEP, HCRT
6positive regulation of cellular protein metabolic processGO:0322709.9AGT, ADIPOQ
7positive regulation of renal sodium excretionGO:0358159.9NPPB, AGT
8cochlea developmentGO:0901029.9KCNK3, KCNK9
9positive regulation of cytokine productionGO:0018199.9AGT, LEP
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.8AGT, HCRT
11negative regulation of potassium ion transportGO:0432679.7HCRT, HTR2A, NOS3
12nitric oxide mediated signal transductionGO:0072639.7AGT, NOS3
13response to hypoxiaGO:0016669.6LEP, ADIPOQ, NPPA
14negative regulation of cell growthGO:0303089.6AGT, NPPB, NPPA
15regulation of blood vessel sizeGO:0508809.6NPPB, NPPA, NOS3
16potassium ion transportGO:0068139.5KCNMB1, KCNK3, KCNK9
17negative regulation of blood pressureGO:0457769.5ADIPOQ, NOS3
18regulation of blood pressureGO:0082179.4NPPB, NPPA, NOS3, LEP
19blood vessel remodelingGO:0019749.2AGT, NOS3
20synaptic transmissionGO:0072689.0KCNK9, KCNK3, KCNMB1, HCRT, HTR2A

Molecular functions related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:0514289.8LEP, NPPA
2receptor bindingGO:0051029.4NPPB, NPPA, ADIPOQ
3potassium channel activityGO:0052679.4KCNK3, KCNK9
4hormone activityGO:0051798.8AGT, NPPB, NPPA, ADIPOQ, LEP

Products for genes affiliated with Sleep Apnea

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  • Antibodies
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Sources for Sleep Apnea

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet