MCID: SLP006
MIFTS: 57

Sleep Apnea malady

Neuronal category

Summaries for Sleep Apnea

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

MalaCards: Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and sleep disorder. An important gene associated with Sleep Apnea is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and G alpha (q) signalling events. The compounds calcium and arginine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are cardiovascular system and muscle.

NINDS:44 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.

Wikipedia:64 Sleep apnea (or sleep apnoea in British English; /æpˈniːə/) is a type of sleep disorder... more...

Aliases & Classifications for Sleep Apnea

Sources:
44NINDS, 34MedlinePlus, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

sleep apnea 44 34
sleep apnea syndromes 61


External Ids:

ICD1025 G47.3

Related Diseases for Sleep Apnea

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 309)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea31.8KCNK9, KCNK3, NPPB, IK
2sleep disorder31.2HCRT, NPS
3narcolepsy30.9LSL, HTR2A, HCRT, LEP
4insulin resistance30.9HSPA1A, LSL, HTR2A, APLN, AGT, MC3R
5acromegaly30.6ADIPOQ, LEP, LSL
6asthma30.6HTR2A, NPS, ADIPOQ
7coronary artery disease,30.5APLN, NPPB, NPPA, AGT, NOS3, ADIPOQ
8prader-willi syndrome30.5LSL, HCRT, LEP, ADIPOQ
9fatty liver disease30.5LSL, LEP, ADIPOQ
10polycystic ovary syndrome30.4LSL, LEP, ADIPOQ
11morbid obesity30.4LEP, MC3R
12stroke, ischemic30.4NOS3, NPPA
13coronary heart disease30.3HSPA1A, NPPB, AGT, LEP, NOS3, ADIPOQ
14vascular disease30.3HTR2A, AGT, NOS3, ADIPOQ
15alzheimer's disease30.3HSPA1A, HTR2A, NPS, HCRT, NOS3
16atherosclerosis30.0LSL, APLN, AGT, LEP, NOS3, ADIPOQ
17acute myocardial infarction30.0HTR2A, NPPB, NPPA, AGT
18uremia30.0ADIPOQ, NOS3, LEP, LSL
19primary pulmonary hypertension30.0NPPB, NPPA, AGT, NOS3
20hypoglycemia30.0LSL, HTR2A, HCRT
21idiopathic edema30.0ADIPOQ, NPPA, NPPB
22diabetic nephropathy30.0NPPA, AGT, NOS3, ADIPOQ
23noonan syndrome30.0APLN, NPPB, NPPA, AGT
24arthritis30.0NPS, LEP, ADIPOQ
25amenorrhea30.0LEP
26gestational diabetes30.0LSL, LEP, ADIPOQ
27cushing's syndrome30.0LSL, LEP, ADIPOQ
28glucose intolerance30.0LSL, LEP, ADIPOQ
29growth hormone deficiency30.0LSL, LEP, ADIPOQ
30n syndrome10.9
31hypersomnia10.7
32hypoxia10.6
33insomnia10.6
34achondroplasia10.5
35laryngomalacia10.5
36char syndrome10.5
37adult syndrome10.5
38craniosynostosis, syndromic10.5
39headache10.5
40patent foramen ovale10.4
41glaucoma sleep apnea10.4
42treacher collins syndrome10.4
43ischemic neuropathy10.4
44periodic limb movement disorder10.4
45systolic heart failure10.4
46ischemic optic neuropathy10.4
47micro syndrome10.4
48autonomic dysfunction10.4
49gastroesophageal reflux disease10.3
50optic neuropathy, anterior ischemic10.3

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to sleep apnea

Clinical Features for Sleep Apnea

Drugs & Therapeutics for Sleep Apnea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Sleep Apnea

Drug clinical trials:

Search ClinicalTrials for Sleep Apnea

Search NIH Clinical Center for Sleep Apnea

Search CenterWatch for Sleep Apnea

Genetic Tests for Sleep Apnea

Anatomical Context for Sleep Apnea

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sleep Apnea:

33
Bone marrow, Whole blood, Brain, Heart, Skeletal muscle, Adipocyte, Kidney, Liver, Lung, Thyroid, Breast, Skin, Ovary, Tonsil, Monocytes, T cells, B cells, Endothelial, Temporal lobe, Tongue

Animal Models for Sleep Apnea or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Sleep Apnea

Sources:
51PubMed
See all sources

Articles related to Sleep Apnea:

(show top 50)    (show all 1259)
idTitleAuthorsYear
1
Palatal sensory threshold reflects nocturnal hypoxemia and airway occlusion in snorers and obstructive sleep apnea patients. (24235900)
2013
2
Regional cerebral blood flow alterations in obstructive sleep apnea. (24076138)
2013
3
The role of overnight pulse-oximetry in recognition of obstructive sleep apnea syndrome in morbidly obese and non obese patients. (24371491)
2013
4
Is there a dynamic change in ischemia-modified albumin in patients with obstructive sleep apnea, which often leads to ischemic diseases? (24270962)
2013
5
Mean platelet volume in patients with obstructive sleep apnea syndrome and its relationship with cardiovascular diseases. (23811801)
2013
6
Variations of snoring properties with macro sleep stages in a population of Obstructive Sleep Apnea patients. (24109938)
2013
7
Obstructive Sleep Apnea in North American Commercial Drivers. (24317450)
2013
8
Influence of sleep apnea severity on blood pressure variability of patients with hypertension. (24092449)
2013
9
Prevalence of symptoms and risk of sleep apnea in patients with ruptured cerebral aneurysm. (23887215)
2013
10
A case of obstructive sleep apnea, gastroesophageal reflux disease, and chronic hiccups: will CPAP help? (23319912)
2013
11
Newer treatment modalities for pediatric obstructive sleep apnea. (23931720)
2013
12
Obstructive sleep apnea and asthma: is it just a matter of CPAP. (24298967)
2013
13
Effects of continuous positive airway pressure therapy in three Japanese patients with obstructive sleep apnea and resistant hypertension. (24088759)
2013
14
Obstructive sleep apnea syndrome aggravated propriospinal myoclonus at sleep onset. (22033123)
2012
15
Respiratory events and obstructive sleep apnea in children with achondroplasia: investigation and treatment outcomes. (21225355)
2011
16
The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea. (22131607)
2011
17
Apolipoprotein E polymorphisms and sleep quality in obstructive sleep apnea syndrome. (21864519)
2011
18
Descriptive analysis of central sleep apnea in childhood at a single center. (21520440)
2011
19
Association of osteopontin and tumor necrosis factor-I+ levels with insulin resistance in obese patients with obstructive sleep apnea syndrome. (20935448)
2011
20
Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea. (20002528)
2010
21
Effective treatment for idiopathic central sleep apnea? (19968045)
2009
22
Central sleep apnea and ataxia caused by brainstem lesion due to chronic neuroleptospirosis. (19949038)
2009
23
Heart failure, central sleep apnea, CPAP, and arousals: another piece of the puzzle. (19189772)
2009
24
Combined adaptive servo-ventilation and automatic positive airway pressure (anticyclic modulated ventilation) in co-existing obstructive and central sleep apnea syndrome and periodic breathing. (19303811)
2009
25
Plasma visfatin levels in severe obstructive sleep apnea-hypopnea syndrome. (19360446)
2009
26
CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome. (19238805)
2009
27
Reciprocal interactions of obstructive sleep apnea and hypertension associated with ACE I/D polymorphism in males. (19482546)
2009
28
Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: a cross-sectional study. (18617307)
2008
29
Are biomarker levels a good follow-up tool for evaluating obstructive sleep apnea syndrome treatments? (18311073)
2008
30
Decreased lipoprotein lipase in obstructive sleep apnea syndrome. (17652898)
2007
31
Obstructive sleep apnea in 2 women with familial partial lipodystrophy due to a heterozygous LMNA R482Q mutation. (17893350)
2007
32
Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulation. (17236808)
2007
33
The significance and outcome of continuous positive airway pressure-related central sleep apnea during split-night sleep studies. (17475636)
2007
34
The association between polymorphism of the serotonin 2A, 2C receptor genes and obstructive sleep apnea-hypopnea syndrome in Han population]. (18336767)
2007
35
Evaluation of the efficacy of supraglottoplasty in obstructive sleep apnea syndrome associated with severe laryngomalacia. (16702563)
2006
36
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
37
Adiponectin in patients with obstructive sleep apnea syndrome: course and physiological relevance. (15627868)
2004
38
Clinical significance of daytime plasma orexin-A-like immunoreactivity concentrations in patients with obstructive sleep apnea hypopnea syndrome. (15316212)
2004
39
A reflectable case of obstructive sleep apnea in an infant with Crouzon syndrome. (15346037)
2004
40
Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. (14720019)
2003
41
Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. (11158002)
2001
42
Central sleep apnea and chronic heart failure. (10893107)
2000
43
A mechanism of central sleep apnea in patients with heart failure. (10498490)
1999
44
Association of low PaCO2 with central sleep apnea and ventricular arrhythmias in ambulatory patients with stable heart failure. (9454528)
1998
45
A noninvasive technique for detecting obstructive and central sleep apnea. (9401226)
1997
46
Glucose tolerance, insulin resistance and arterial hypertension in patients with obstructive sleep apnea syndrome]. (7617595)
1995
47
Obstructive sleep apnea in the Rubinstein-Taybi syndrome. (8341855)
1993
48
Severe adult hypersomnia--sleep apnea syndrome in craniofacial dysostosis. (3749615)
1986
49
Achondroplasia associated with obstructive sleep apnea. (6625996)
1983
50
Sleep apnea and nocturnal hypoventilation after western equine encephalitis. (6849538)
1983

Genetic Variations for Sleep Apnea

Expression for genes affiliated with Sleep Apnea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for genes affiliated with Sleep Apnea

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Sleep Apnea

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.4KCNK9, NPPA, LSL, KCNMB1, HSPA1A, APLN
2arginine4511.3LSL, KCNK3, HSPA1A, NPPA, ADIPOQ, AGT
3glucose4511.2NPPB, ADIPOQ, AGT, HSPA1A, LSL, LEP
4epinephrine45 11 2413.2LEP, HSPA1A, LSL, NPPB, NPPA, HCRT
5phenylephrine45 29 11 2414.2NPPB, NPPA, AGT, LEP, HCRT, NOS3
6potassium45 11 2413.2KCNK9, HSPA1A, KCNMB1, KCNK3, NPPA, AGT
7haloperidol45 29 2 50 1115.2NPPB, HTR2A, NPPA, AGT, HCRT, LSL
8prostacyclin4511.2NPPB, NPPA, AGT, LEP, NOS3, ADIPOQ
9acth4511.1LSL, NPPA, LEP, MC3R, HCRT, AGT
10amlodipine45 50 11 2414.1NPPB, NPPA, ADIPOQ, AGT, NOS3
11dopamine45 29 11 2414.1NPPB, NPPA, HTR2A, MC3R, AGT, ADIPOQ
128-isoprostane4511.1ADIPOQ, NOS3, LEP, HSPA1A, NPPB
13nitric oxide45 11 2413.1NOS3, HCRT, AGT, NPPA, NPPB, APLN
14l-nmma4511.1NPPA, NPPB, AGT, LEP, NOS3
15c-peptide4511.1HCRT, AGT, LEP, LSL, ADIPOQ
16creatinine4511.1ADIPOQ, LSL, HSPA1A, NPPB, NPPA, LEP
17losartan45 50 29 1114.1NPPA, ADIPOQ, NPPB, LEP, AGT
18pravastatin45 50 29 11 2415.1LSL, ADIPOQ, NOS3, LEP, NPPB
19metoprolol45 29 50 11 2415.1NPPA, NOS3, ADIPOQ, NPPB
20telmisartan45 29 1113.1LEP, ADIPOQ, AGT, NPPB
21perindopril45 50 1113.1NOS3, NPPA, NPPB, AGT
22norepinephrine45 11 2413.1HCRT, HSPA1A, HTR2A
23candesartan45 29 1113.0NPPB, NOS3, ADIPOQ, AGT
24acetylcholine45 50 29 11 2415.0AGT, NPPB, ADIPOQ, HCRT, NOS3, LEP
25sodium nitroprusside4511.0NPPA, NPPB, LEP, NOS3, ADIPOQ
26homocysteine45 2412.0NOS3, AGT, NPPB, LSL, ADIPOQ
27enalapril45 50 1113.0NPPB, NPPA, ADIPOQ, AGT
28zacopride hydrochloride6011.0HTR3C, HTR3D, HTR3E
29thyroxine45 2412.0NPPB, ADIPOQ, LEP, HCRT, LSL
30granisetron hydrochloride6011.0HTR3E, HTR3D, HTR3C
31sr 57227 hydrochloride6011.0HTR3E, HTR3C, HTR3D
32ondansetron hydrochloride6011.0HTR3E, HTR3D, HTR3C
33tropisetron hydrochloride6011.0HTR3E, HTR3D, HTR3C
34ang ii4511.0NPPA, AGT, NOS3, NPPB
35estradiol45 11 2412.9LEP, HCRT, NPPB, AGT, LSL, ADIPOQ
36rosiglitazone45 50 29 11 2414.9NPPB, LSL, LEP
37thapsigargin45 6011.9NOS3, HSPA1A, NPPB, HCRT, ADIPOQ
38olanzapine50 45 29 11 2414.9LEP, LSL, ADIPOQ, HTR2A
39hanp4510.9ADIPOQ, NPPA, NPPB
40glycerol45 11 2412.9NOS3, LEP, NPPA, LSL, ADIPOQ
41rimonabant45 29 1112.9LEP, HCRT, ADIPOQ
42dexamethasone45 50 29 1113.8ADIPOQ, LEP, HCRT, AGT, NPPB, LSL
43estrogen4510.8NPPB
44enalaprilat4510.8NPPA, NPPB, AGT
45sibutramine45 1111.7ADIPOQ, LEP, LSL
46lisinopril45 11 2412.7NPPB, NPPA, AGT
47acipimox45 2911.6ADIPOQ, LEP, LSL
488-bromo cgmp4510.6AGT, NPPA, NPPB
49ramipril45 1111.5NPPA, NPPB, ADIPOQ
50atenolol45 29 50 11 2414.3AGT, LEP, NPPB

GO Terms for genes affiliated with Sleep Apnea

Sources:
16Gene Ontology
See all sources

Cellular components related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8NPS, NPPB, NPPA, AGT, HCRT, LEP
2extracellular spaceGO:00561510.5ADIPOQ, APLN, NPPB, NPPA, AGT, IK

Biological processes related to Sleep Apnea according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821711.0NOS3, LEP, MC3R, NPPA, NPPB
2negative regulation of potassium ion transportGO:04326710.9NOS3, HCRT, HTR2A
3synaptic transmissionGO:00726810.9KCNK9, KCNMB1, KCNK3, HTR2A, HCRT
4regulation of blood vessel sizeGO:05088010.9NPPB, NPPA, NOS3
5negative regulation of blood pressureGO:04577610.8ADIPOQ, NOS3, APLN
6phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.8AGT, HCRT, MC3R
7negative regulation of vasoconstrictionGO:04590610.8LEP, APLN
8ovulation from ovarian follicleGO:00154210.7NOS3, LEP
9cGMP biosynthetic processGO:00618210.7NPPB, NPPA
10potassium ion transportGO:00681310.7KCNK3, KCNMB1, KCNK9
11receptor guanylyl cyclase signaling pathwayGO:00716810.6NPPB, NPPA
12positive regulation of cellular protein metabolic processGO:03227010.6ADIPOQ, AGT
13nitric oxide mediated signal transductionGO:00726310.6NOS3, AGT
14positive regulation of renal sodium excretionGO:03581510.5AGT, NPPB
15cochlea developmentGO:09010210.3KCNK3, KCNK9

Molecular functions related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7ADIPOQ, LEP, AGT, NPPA, NPPB, APLN
2receptor bindingGO:00510210.6ADIPOQ, NPPA, NPPB, APLN
3extracellular ligand-gated ion channel activityGO:00523010.5HTR3E, HTR3D, HTR3C
4peptide hormone receptor bindingGO:05142810.3LEP, NPPA

Products for genes affiliated with Sleep Apnea

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Sources for Sleep Apnea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet