Aliases & Classifications for Sleep Apnea

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Sleep Apnea, Aliases & Descriptions:

Name: Sleep Apnea 9 42 32
 
Sleep Apnea Syndromes 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:0050847
ICD1025 G47.3

Summaries for Sleep Apnea

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MedlinePlus:32 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

MalaCards based summary: Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obstructive sleep apnea. An important gene associated with Sleep Apnea is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds rimonabant and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and tonsil, and related mouse phenotypes are adipose tissue and respiratory system.

Disease Ontology:9 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

NINDS:42 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.

Wikipedia:63 Sleep apnea (or sleep apnoea in British English; / more...

Related Diseases for Sleep Apnea

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Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 298)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea32.2KCNK9, KCNK3, NPPB
2obstructive sleep apnea31.9HCRT, LEP, HSPA1A, ADIPOQ, HTR2A, AGT
3narcolepsy31.4HTR2A, LEP, HCRT
4congestive heart failure31.3NPPA, NPPB, AGT
5pulmonary hypertension31.3NPPA, NPPB
6atrial fibrillation31.2NPPA, NPPB
7morbid obesity31.1LEP
8obesity31.1HCRT, LEP, ADIPOQ, HTR2A, NOS3, AGT
9hypothyroidism31.1LEP, ADIPOQ
10prader-willi syndrome31.0HCRT, LEP, ADIPOQ
11cor pulmonale30.8NPPB, NPPA
12lipodystrophy30.7ADIPOQ, LEP
13growth hormone deficiency30.5LEP, ADIPOQ
14coronary artery disease30.5AGT, NPPB, NPPA, NOS3
15idiopathic edema30.4NPPB, NPPA, ADIPOQ
16proteinuria30.4AGT, NOS3, ADIPOQ
17mood disorder30.4NOS3, HTR2A, HCRT
18uremia30.3LEP, ADIPOQ, NOS3
19acute myocardial infarction30.2HTR2A, NPPA, NPPB, AGT
20atherosclerosis30.2AGT, NOS3, ADIPOQ, LEP
21vascular disease30.0ADIPOQ, HTR2A, NOS3, AGT
22ischemia30.0HCRT, HSPA1A, NOS3, NPPB, AGT
23myocardial infarction30.0ADIPOQ, HTR2A, NOS3, NPPA, NPPB, AGT
24hypersomnia10.7
25hypoxia10.7
26endotheliitis10.7
27sleep disorder10.7
28pharyngitis10.6
29neuropathy10.6
30laryngomalacia10.6
31achondroplasia10.6
32headache10.5
33mitral valve disease10.5NPPA
34sick sinus syndrome10.5NPPA
35craniosynostosis10.5
36cerebritis10.5
37acromegaly10.5
38glaucoma sleep apnea10.5
39adiponectin deficiency10.5ADIPOQ
40gastroesophageal reflux10.5
41bruxism10.5
42periodic limb movement disorder10.5
43patent foramen ovale10.5
44rem sleep behavior disorder10.5
45retinitis10.5
46gitelman syndrome10.4AGT
47asthma10.4
48ischemic optic neuropathy10.4
49systolic heart failure10.4
50artery disease10.4

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to sleep apnea

Symptoms for Sleep Apnea

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Drugs & Therapeutics for Sleep Apnea

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Drug clinical trials:

Search ClinicalTrials for Sleep Apnea

Search NIH Clinical Center for Sleep Apnea

Genetic Tests for Sleep Apnea

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Anatomical Context for Sleep Apnea

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MalaCards organs/tissues related to Sleep Apnea:

31
Heart, Lung, Tonsil, Endothelial, Brain, Kidney, Testes, Bone, Liver, Eye, Ovary, Monocytes, Tongue, Bone marrow, Whole blood, Adipocyte, Thyroid, Breast, Skin, T cells, Neutrophil

Animal Models for Sleep Apnea or affiliated genes

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Publications for Sleep Apnea

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Articles related to Sleep Apnea:

(show top 50)    (show all 1360)
idTitleAuthorsYear
1
Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea: A systematic review and meta-analysis. (25389029)
2014
2
Functional Comorbidity Index in Sleep Apnea. (24395621)
2014
3
Association of glucose transporter 4 genetic Polymorphisms with obstructive sleep apnea syndrome in Han Chinese general population: a cross-section study. (24410986)
2014
4
Upper Airway Stimulation for Obstructive Sleep Apnea: Past, Present, and Future. (25409109)
2014
5
Assessment of the effect of bariatric surgery on obstructive sleep apnea at two postoperative intervals. (23856989)
2014
6
Obstructive sleep apnea. (25364899)
2014
7
The evaluation of body composition, adiponectin, C-reactive protein and cholesterol levels in patients with obstructive sleep apnea syndrome. (24431310)
2013
8
Lipopolysaccharide-Binding Protein Plasma Levels in Children: Effects of Obstructive Sleep Apnea and Obesity. (24276451)
2013
9
Positive airway pressure therapy in patients with opioid-related central sleep apnea. (24062011)
2013
10
Letter regarding the review by Zhang et al. of portable recording for the diagnosis of obstructive sleep apnea in commercial motor vehicle drivers. (23904687)
2013
11
Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. (22974765)
2013
12
Obstructive sleep apnea as a risk factor after shoulder arthroplasty. (24045126)
2013
13
Executive dysfunction in children affected by obstructive sleep apnea syndrome: an observational study. (23976855)
2013
14
Effect of Qingxuan Granule () on blood pressure variability of hypertensive patients with and without obstructive sleep apnea. (24126974)
2013
15
Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. (22924163)
2013
16
Automated detection of sleep apnea in infants using minimally invasive sensors. (24110021)
2013
17
Obstructive sleep apnea (OSA) in preadolescent girls is associated with delayed breast development compared to girls without OSA. (23946712)
2013
18
Palatal sensory threshold reflects nocturnal hypoxemia and airway occlusion in snorers and obstructive sleep apnea patients. (24235900)
2013
19
Effectiveness of three sleep apnea management alternatives. (24293754)
2013
20
Obstructive sleep apnea does not promote esophageal reflux in fibrosing interstitial lung disease. (22521226)
2012
21
Late-onset laryngomalacia: a cause of pediatric obstructive sleep apnea. (21115204)
2011
22
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
23
Obstructive sleep apnea among patients with retinal vein occlusion. (21149775)
2010
24
Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome]. (20367952)
2010
25
Central sleep apnea. (20488284)
2010
26
Patent foramen ovale and obstructive sleep apnea: a new association? (20451427)
2010
27
Risk factors for obstructive sleep apnea syndrome screening in mood disorder patients. (19566771)
2009
28
Validity and reliability of Sleep Quality Scale in subjects with obstructive sleep apnea syndrome. (19073298)
2009
29
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
30
Idiopathic intracranial hypertension in men and the relationship to sleep apnea. (18923134)
2009
31
Role of continuous positive airway pressure therapy on the pathogenesis of sleep-related frontal lobe epilepsy in a child with obstructive sleep apnea syndrome. (18079319)
2008
32
Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP). (18780208)
2008
33
Increased low-grade inflammation and plasminogen-activator inhibitor-1 level in nondippers with sleep apnea syndrome. (18475156)
2008
34
Serum angiotensin converting enzyme and the obstructive sleep apnea hypopnea syndrome. (18763423)
2008
35
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
36
Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. (17667845)
2007
37
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
38
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. (16839844)
2006
39
Effects of nasal continuous positive airway pressure short-term treatment on C-reactive protein and intercellular adhesion molecule-1 in patients with obstructive sleep apnea-hypopnea syndrome]. (16708805)
2005
40
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
41
Idiopathic edema is associated with obstructive sleep apnea in women. (15511705)
2004
42
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
43
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
44
Obstructive sleep apnea in children with achondroplasia: surgical and anesthetic considerations. (9949360)
1999
45
Central sleep apnea after interrupting longterm acetazolamide therapy. (9696283)
1998
46
Continuous versus bilevel positive airway pressure in a patient with idiopathic central sleep apnea. (9105099)
1997
47
Relationship of nasal continuous positive airway pressure to periodic limb movement disorder in a patient without sleep apnea. (8486056)
1993
48
Nasal continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea in Hallermann-Streiff syndrome. (2406080)
1990
49
Achondroplasia and obstructive sleep apnea: correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy. (4041579)
1985
50
Achondroplasia associated with obstructive sleep apnea. (6625996)
1983

Variations for Sleep Apnea

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Expression for genes affiliated with Sleep Apnea

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Search GEO for disease gene expression data for Sleep Apnea.

Pathways for genes affiliated with Sleep Apnea

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Pathways related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NPPB, NPPA
2
Show member pathways
9.5NOS3, AGT
3
Show member pathways
9.5HCRT, HTR2A, AGT
4
Show member pathways
9.4NOS3, KCNMB1
59.4AGT, ADIPOQ, LEP
6
Show member pathways
9.4AGT, ADIPOQ, LEP
79.4NPPA, NPPB, AGT
8
Show member pathways
9.3NOS3, HSPA1A
9
Show member pathways
9.3AGT, HTR2A, LEP, HCRT
10
Show member pathways
9.2KCNMB1, KCNK3, KCNK9
11
Show member pathways
9.1HSPA1A, KCNK3, KCNK9
12
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.7NPPB, NOS3, HTR2A, HSPA1A

Compounds for genes affiliated with Sleep Apnea

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Compounds related to Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1rimonabant43 28 1211.9HCRT, ADIPOQ, LEP
2oxyntomodulin43 5910.8ADIPOQ, LEP, HCRT
3hanp439.8NPPB, NPPA, ADIPOQ
4ramipril43 1210.8NPPB, NPPA, ADIPOQ
5enalaprilat439.8NPPA, AGT, NPPB
6lisinopril43 49 24 1212.7AGT, NPPA, NPPB
78-bromo cgmp439.7NPPB, AGT, NPPA
8atenolol43 49 28 24 1213.7NPPB, LEP, AGT
9valsartan43 59 28 1212.7ADIPOQ, AGT, NPPB
10c-peptide439.5HCRT, LEP, ADIPOQ, AGT
11telmisartan43 28 1211.5AGT, NPPB, ADIPOQ, LEP
12n(g)-nitro-l-arginine methyl ester439.5AGT, NOS3, LEP
13enalapril43 49 1211.4AGT, NPPA, ADIPOQ, NPPB
14metoprolol43 49 28 24 1213.3NPPB, ADIPOQ, NPPA, NOS3
15aminoguanidine43 28 1211.3NOS3, HSPA1A, LEP
16pravastatin43 49 28 24 1213.3NPPB, ADIPOQ, LEP, NOS3
17perindopril43 49 1211.3AGT, NOS3, NPPA, NPPB
18haloperidol43 49 28 2 1213.3AGT, NPPB, HTR2A, HCRT, NPPA
19ang ii439.3NPPA, NOS3, AGT, NPPB
20candesartan43 49 28 1212.2AGT, NOS3, ADIPOQ, NPPB
21ng-nitro-l-arginine439.2NOS3, AGT, NPPA
22losartan43 49 28 1212.2AGT, LEP, ADIPOQ, NPPA, NPPB
23guanylate439.2NPPB, NPPA, NOS3, AGT
24homocysteine43 2410.1NPPB, AGT, NOS3, ADIPOQ
25rosiglitazone28 43 49 24 1213.1NPPB, ADIPOQ, LEP, NOS3
26sodium nitroprusside439.1NPPA, LEP, ADIPOQ, NOS3, NPPB
27l-nmma439.1LEP, NOS3, NPPA, NPPB, AGT
28atorvastatin43 49 28 24 1213.0ADIPOQ, NOS3, NPPB, AGT
29nifedipine43 28 49 1212.0LEP, ADIPOQ, NPPA, AGT
30amlodipine43 49 24 1212.0AGT, NPPA, NPPB, NOS3, ADIPOQ
31estradiol43 24 1210.9ADIPOQ, HCRT, AGT, NPPB, LEP
32dopamine43 28 24 1211.9HCRT, ADIPOQ, NPPA, NPPB, AGT, HTR2A
33phenylephrine43 28 24 1211.8NPPA, NOS3, LEP, HCRT, AGT, NPPB
348-isoprostane438.8LEP, NPPB, NOS3, ADIPOQ, HSPA1A
35thapsigargin43 599.8NOS3, ADIPOQ, HSPA1A, HCRT, NPPB
36acetylcholine43 49 28 24 1212.7NPPB, ADIPOQ, HCRT, LEP, AGT, NOS3
37epinephrine43 24 1210.7AGT, NPPB, NPPA, HSPA1A, LEP, HCRT
38prostacyclin438.7LEP, ADIPOQ, NOS3, NPPA, AGT, NPPB
39sb 20358043 599.6ADIPOQ, HSPA1A, NOS3, NPPB, AGT
40dexamethasone43 49 28 1211.5HSPA1A, HCRT, AGT, NPPB, ADIPOQ, LEP
41creatinine438.5LEP, AGT, NPPB, NPPA, ADIPOQ, HSPA1A
42cyclosporin a43 28 5910.5LEP, NPPA, NPPB, AGT, HSPA1A
43actinomycin d438.5AGT, HSPA1A, ADIPOQ, NOS3, NPPB
44estrogen438.1NPPB, HCRT, NPPA, NOS3, ADIPOQ, HSPA1A
45nitric oxide43 24 1210.1AGT, NPPB, NPPA, NOS3, HSPA1A, HCRT
46norepinephrine43 24 1210.1HTR2A, NPPA, NPPB, AGT, HSPA1A, ADIPOQ
47potassium43 24 1210.0NPPA, AGT, HSPA1A, HCRT, KCNK9, KCNMB1
48glutamate438.0ADIPOQ, LEP, KCNK3, HCRT, NOS3, KCNK9
49arginine437.7KCNK3, NOS3, ADIPOQ, HSPA1A, LEP, NPPA
50calcium43 49 24 1210.1AGT, HSPA1A, KCNK9, KCNMB1, HTR2A, NOS3

GO Terms for genes affiliated with Sleep Apnea

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Cellular components related to Sleep Apnea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.8AGT, NPPB, NPPA, ADIPOQ, LEP
2extracellular regionGO:00055768.2AGT, HCRT, LEP, ADIPOQ, NPPA, NPPB

Biological processes related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:000618210.1NPPB, NPPA
2artery smooth muscle contractionGO:001482410.1HTR2A, AGT
3receptor guanylyl cyclase signaling pathwayGO:000716810.1NPPA, NPPB
4ovulation from ovarian follicleGO:000154210.0LEP, NOS3
5eating behaviorGO:004275510.0LEP, HCRT
6positive regulation of cellular protein metabolic processGO:00322709.9AGT, ADIPOQ
7positive regulation of renal sodium excretionGO:00358159.9NPPB, AGT
8cochlea developmentGO:00901029.9KCNK3, KCNK9
9positive regulation of cytokine productionGO:00018199.9AGT, LEP
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.8AGT, HCRT
11negative regulation of potassium ion transportGO:00432679.7HCRT, HTR2A, NOS3
12nitric oxide mediated signal transductionGO:00072639.7AGT, NOS3
13response to hypoxiaGO:00016669.6LEP, ADIPOQ, NPPA
14negative regulation of cell growthGO:00303089.6AGT, NPPB, NPPA
15regulation of blood vessel sizeGO:00508809.6NPPB, NPPA, NOS3
16potassium ion transportGO:00068139.5KCNMB1, KCNK3, KCNK9
17negative regulation of blood pressureGO:00457769.5ADIPOQ, NOS3
18regulation of blood pressureGO:00082179.4NPPB, NPPA, NOS3, LEP
19blood vessel remodelingGO:00019749.2AGT, NOS3
20synaptic transmissionGO:00072689.0KCNK9, KCNK3, KCNMB1, HCRT, HTR2A

Molecular functions related to Sleep Apnea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:00514289.8LEP, NPPA
2receptor bindingGO:00051029.4NPPB, NPPA, ADIPOQ
3potassium channel activityGO:00052679.4KCNK3, KCNK9
4hormone activityGO:00051798.8AGT, NPPB, NPPA, ADIPOQ, LEP

Products for genes affiliated with Sleep Apnea

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Sources for Sleep Apnea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet