MCID: SLP006
MIFTS: 44

Sleep Apnea malady

Neuronal diseases category

Summaries for Sleep Apnea

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

MalaCards: Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obesity. An important gene associated with Sleep Apnea is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and G alpha (q) signalling events. The compounds calcium and arginine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related mouse phenotypes are cardiovascular system and muscle.

NINDS:43 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.

Wikipedia:63 Sleep apnea (or sleep apnoea in British English; /æpˈniːə/) is a type of sleep disorder... more...

Aliases & Classifications for Sleep Apnea

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Sources:
43NINDS, 33MedlinePlus, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

sleep apnea 43 33
sleep apnea syndromes 60


External Ids:

ICD1025 G47.3

Related Diseases for Sleep Apnea

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Sleep Apnea family:

sleep apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea31.8KCNK9, KCNK3, NPPB, IK
2obesity31.4LSL, HTR2A, APLN, AGT, HCRT, MC3R
3hypertension31.3NPPB, NPPA, AGT, LEP, NOS3
4sleep disorder31.2HCRT, NPS
5congestive heart failure31.0AGT, NPPA, NPPB, APLN
6narcolepsy30.9LSL, HTR2A, HCRT, LEP
7acromegaly30.6ADIPOQ, LEP, LSL
8asthma30.5HTR2A, NPS, ADIPOQ
9hypothyroidism30.5LEP, LSL
10diabetes mellitus30.5LSL, NPS, NPPB, NPPA, AGT, LEP
11coronary artery disease30.5APLN, NPPB, NPPA, AGT, NOS3, ADIPOQ
12ischemic heart disease30.5AGT, NPPA, NPPB, LSL, NOS3
13prader-willi syndrome30.5LSL, HCRT, LEP, ADIPOQ
14fatty liver disease30.5LSL, LEP, ADIPOQ
15myocardial infarction30.4LSL, HTR2A, NPPB, NPPA, AGT, NOS3
16type 2 diabetes mellitus30.4LSL, HTR2A, AGT, LEP, NOS3, ADIPOQ
17ischemia30.4HSPA1A, NPPB, AGT, HCRT, NOS3
18polycystic ovary syndrome30.4LSL, LEP, ADIPOQ
19morbid obesity30.4LEP, MC3R
20stroke, ischemic30.4NOS3, NPPA
21vascular disease30.2HTR2A, AGT, NOS3, ADIPOQ
22dilated cardiomyopathy30.2NPPA, NPPB
23hyperaldosteronism30.2NPPA
24mood disorder30.2HTR2A, HCRT, NOS3
25alzheimer's disease30.2HSPA1A, HTR2A, NPS, HCRT, NOS3
26essential hypertension30.0HSPA1A, HTR2A, NPPB, NPPA, AGT, LEP
27atherosclerosis30.0LSL, APLN, AGT, LEP, NOS3, ADIPOQ
28acute myocardial infarction30.0HTR2A, NPPB, NPPA, AGT
29proteinuria30.0LSL, AGT, NOS3, ADIPOQ
30uremia30.0ADIPOQ, NOS3, LEP, LSL
31primary pulmonary hypertension30.0NPPB, NPPA, AGT, NOS3
32hypoglycemia30.0LSL, HTR2A, HCRT
33heart valve disease30.0NPPA, NPPB, HTR2A
34diabetic nephropathy30.0NPPA, AGT, NOS3, ADIPOQ
35dementia30.0HCRT, HTR2A
36noonan syndrome30.0APLN, NPPB, NPPA, AGT
37diabetic retinopathy30.0NOS3, AGT
38arthritis30.0NPS, LEP, ADIPOQ
39amenorrhea30.0LEP
40gestational diabetes30.0LSL, LEP, ADIPOQ
41cushing's syndrome30.0LSL, LEP, ADIPOQ
42glucose intolerance30.0LSL, LEP, ADIPOQ
43rhinitis30.0NPS
44pharyngitis10.5
45neuropathy10.5
46achondroplasia10.5
47craniosynostosis10.5
48cerebritis10.4
49adult syndrome10.4
50patent foramen ovale10.4

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to sleep apnea

Clinical Features for Sleep Apnea

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Drugs & Therapeutics for Sleep Apnea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sleep Apnea

Drug clinical trials:

Search ClinicalTrials for Sleep Apnea

Search NIH Clinical Center for Sleep Apnea

Search CenterWatch for Sleep Apnea

Genetic Tests for Sleep Apnea

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Anatomical Context for Sleep Apnea

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32MalaCards
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MalaCards organs/tissues related to Sleep Apnea:

32
Heart, Lung, Testes, Tonsil

Animal Models for Sleep Apnea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sleep Apnea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.1ADIPOQ, HSPA1A, KCNK9, KCNMB1, KCNK3, APLN
2MP:000536911.0ADIPOQ, NOS3, LEP, HCRT, AGT, NPPA
3MP:000537610.9NOS3, AGT, HSPA1A, KCNK9, KCNK3, APLN
4MP:000538610.7APLN, HTR2A, HCRT, MC3R, LEP, NOS3
5MP:000537510.7ADIPOQ, NOS3, LEP, MC3R, AGT
6MP:000536710.4KCNMB1, ADIPOQ, NOS3, LEP, AGT, NPPA

Publications for Sleep Apnea

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Genetic Variations for Sleep Apnea

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Expression for genes affiliated with Sleep Apnea

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for genes affiliated with Sleep Apnea

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Sleep Apnea

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.4KCNK9, NPPA, LSL, KCNMB1, HSPA1A, APLN
2arginine4411.3LSL, KCNK3, HSPA1A, NPPA, ADIPOQ, AGT
3glucose4411.2NPPB, ADIPOQ, AGT, HSPA1A, LSL, LEP
4epinephrine44 11 2413.2LEP, HSPA1A, LSL, NPPB, NPPA, HCRT
5phenylephrine44 28 11 2414.2NPPB, NPPA, AGT, LEP, HCRT, NOS3
6potassium44 11 2413.2KCNK9, HSPA1A, KCNMB1, KCNK3, NPPA, AGT
7haloperidol44 28 2 49 1115.2NPPB, HTR2A, NPPA, AGT, HCRT, LSL
8prostacyclin4411.2NPPB, NPPA, AGT, LEP, NOS3, ADIPOQ
9acth4411.1LSL, NPPA, LEP, MC3R, HCRT, AGT
10amlodipine44 49 11 2414.1NPPB, NPPA, ADIPOQ, AGT, NOS3
11dopamine44 28 11 2414.1NPPB, NPPA, HTR2A, MC3R, AGT, ADIPOQ
128-isoprostane4411.1ADIPOQ, NOS3, LEP, HSPA1A, NPPB
13nitric oxide44 11 2413.1NOS3, HCRT, AGT, NPPA, NPPB, APLN
14l-nmma4411.1NPPA, NPPB, AGT, LEP, NOS3
15c-peptide4411.1HCRT, AGT, LEP, LSL, ADIPOQ
16creatinine4411.1ADIPOQ, LSL, HSPA1A, NPPB, NPPA, LEP
17losartan44 49 28 1114.1NPPA, ADIPOQ, NPPB, LEP, AGT
18pravastatin44 49 28 11 2415.1LSL, ADIPOQ, NOS3, LEP, NPPB
19metoprolol44 28 49 11 2415.1NPPA, NOS3, ADIPOQ, NPPB
20telmisartan44 28 1113.1LEP, ADIPOQ, AGT, NPPB
21perindopril44 49 1113.1NOS3, NPPA, NPPB, AGT
22norepinephrine44 11 2413.1HCRT, HSPA1A, HTR2A
23candesartan44 28 1113.0NPPB, NOS3, ADIPOQ, AGT
24acetylcholine44 49 28 11 2415.0AGT, NPPB, ADIPOQ, HCRT, NOS3, LEP
25sodium nitroprusside4411.0NPPA, NPPB, LEP, NOS3, ADIPOQ
26homocysteine44 2412.0NOS3, AGT, NPPB, LSL, ADIPOQ
27enalapril44 49 1113.0NPPB, NPPA, ADIPOQ, AGT
28zacopride hydrochloride5911.0HTR3C, HTR3D, HTR3E
29thyroxine44 2412.0NPPB, ADIPOQ, LEP, HCRT, LSL
30granisetron hydrochloride5911.0HTR3E, HTR3D, HTR3C
31sr 57227 hydrochloride5911.0HTR3E, HTR3C, HTR3D
32ondansetron hydrochloride5911.0HTR3E, HTR3D, HTR3C
33tropisetron hydrochloride5911.0HTR3E, HTR3D, HTR3C
34ang ii4411.0NPPA, AGT, NOS3, NPPB
35estradiol44 11 2412.9LEP, HCRT, NPPB, AGT, LSL, ADIPOQ
36rosiglitazone44 49 28 11 2414.9NPPB, LSL, LEP
37thapsigargin44 5911.9NOS3, HSPA1A, NPPB, HCRT, ADIPOQ
38olanzapine49 44 28 11 2414.9LEP, LSL, ADIPOQ, HTR2A
39hanp4410.9ADIPOQ, NPPA, NPPB
40glycerol44 11 2412.9NOS3, LEP, NPPA, LSL, ADIPOQ
41rimonabant44 28 1112.9LEP, HCRT, ADIPOQ
42dexamethasone44 49 28 1113.8ADIPOQ, LEP, HCRT, AGT, NPPB, LSL
43estrogen4410.8NPPB
44enalaprilat4410.8NPPA, NPPB, AGT
45sibutramine44 1111.7ADIPOQ, LEP, LSL
46lisinopril44 11 2412.7NPPB, NPPA, AGT
47acipimox44 2811.6ADIPOQ, LEP, LSL
488-bromo cgmp4410.6AGT, NPPA, NPPB
49ramipril44 1111.5NPPA, NPPB, ADIPOQ
50atenolol44 28 49 11 2414.3AGT, LEP, NPPB

GO Terms for genes affiliated with Sleep Apnea

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16Gene Ontology
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Cellular components related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8APLN, NPS, NPPB, NPPA, AGT, HCRT
2extracellular spaceGO:00561510.5APLN, NPPB, NPPA, AGT, IK, LEP

Biological processes related to Sleep Apnea according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821711.0NOS3, MC3R, NPPA, LEP, NPPB
2negative regulation of potassium ion transportGO:04326710.9NOS3, HCRT, HTR2A
3synaptic transmissionGO:00726810.9HTR2A, KCNK9, KCNMB1, KCNK3, HCRT
4regulation of blood vessel sizeGO:05088010.9NPPB, NPPA, NOS3
5negative regulation of blood pressureGO:04577610.8ADIPOQ, NOS3, APLN
6phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.8HCRT, AGT, MC3R
7negative regulation of vasoconstrictionGO:04590610.8APLN, LEP
8ovulation from ovarian follicleGO:00154210.7LEP, NOS3
9cGMP biosynthetic processGO:00618210.7NPPB, NPPA
10potassium ion transportGO:00681310.7KCNK3, KCNK9, KCNMB1
11receptor guanylyl cyclase signaling pathwayGO:00716810.6NPPB, NPPA
12positive regulation of cellular protein metabolic processGO:03227010.6ADIPOQ, AGT
13nitric oxide mediated signal transductionGO:00726310.6AGT, NOS3
14cochlea developmentGO:09010210.5KCNK3, KCNK9
15positive regulation of renal sodium excretionGO:03581510.3AGT, NPPB

Molecular functions related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7NPPA, NPPB, AGT, LEP, ADIPOQ, APLN
2receptor bindingGO:00510210.6APLN, NPPB, NPPA, ADIPOQ
3extracellular ligand-gated ion channel activityGO:00523010.5HTR3D, HTR3E, HTR3C
4peptide hormone receptor bindingGO:05142810.3LEP, NPPA

Products for genes affiliated with Sleep Apnea

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Sources for Sleep Apnea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet