MCID: SLP006
MIFTS: 59

Sleep Apnea malady

Neuronal diseases, Mental diseases categories
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Summaries for Sleep Apnea

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MedlinePlus:33 Sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

MalaCards based summary: Sleep Apnea, also known as sleep apnea syndromes, is related to central sleep apnea and obstructive sleep apnea. An important gene associated with Sleep Apnea is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The compounds rimonabant and oxyntomodulin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and tonsil, and related mouse phenotypes are adipose tissue and respiratory system.

Disease Ontology:8 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

NINDS:43 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.

Wikipedia:65 Sleep apnea (or sleep apnoea in British English; / more...

Aliases & Classifications for Sleep Apnea

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Sleep Apnea, Aliases & Descriptions:

Name: Sleep Apnea 8 43 33
 
Sleep Apnea Syndromes 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Mental diseases


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Disease Ontology8 DOID:0050847
ICD1025 G47.3

Related Diseases for Sleep Apnea

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Diseases in the Central Sleep Apnea family:

sleep apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1central sleep apnea32.2NPPB, KCNK3, KCNK9
2obstructive sleep apnea31.9HTR2A, HCRT, LEP, HSPA1A, ADIPOQ, AGT
3narcolepsy31.4HTR2A, LEP, HCRT
4congestive heart failure31.4NPPB, AGT, NPPA
5hypertension31.2AGT, LEP, NOS3, NPPA, NPPB
6obesity31.1HTR2A, HCRT, LEP, ADIPOQ, AGT, NOS3
7hypothyroidism31.1LEP, ADIPOQ
8morbid obesity31.0LEP
9prader-willi syndrome30.9ADIPOQ, HCRT, LEP
10cor pulmonale30.8NPPA, NPPB
11pulmonary hypertension30.7NPPA, NOS3, AGT, NPPB
12lipodystrophy30.7ADIPOQ, LEP
13primary pulmonary hypertension30.7NPPB, NPPA
14growth hormone deficiency30.5LEP, ADIPOQ
15gestational diabetes30.4LEP, ADIPOQ
16idiopathic edema30.4ADIPOQ, NPPA, NPPB
17mood disorder30.4HCRT, HTR2A, NOS3
18insulin resistance30.3LEP, HSPA1A, ADIPOQ, HTR2A, NOS3, AGT
19noonan syndrome30.3NPPA, AGT, NPPB
20uremia30.3NOS3, ADIPOQ, LEP
21type 2 diabetes mellitus30.3ADIPOQ, HTR2A, AGT, LEP, NOS3
22cerebrovascular disease30.2NPPA, AGT, HTR2A, NOS3, NPPB
23acute myocardial infarction30.2NPPA, HTR2A, AGT, NPPB
24diabetes mellitus30.2AGT, NPPA, LEP, NOS3, NPPB, ADIPOQ
25proteinuria30.2ADIPOQ, NOS3, AGT
26vascular disease30.0AGT, NOS3, HTR2A, ADIPOQ
27ischemia30.0NPPB, HSPA1A, NOS3, AGT, HCRT
28diabetic nephropathy30.0AGT, NPPA, ADIPOQ, NOS3
29alzheimer's disease30.0NOS3, HTR2A, HCRT, HSPA1A
30type 1 diabetes mellitus30.0LEP, HSPA1A, AGT, NPPA
31myocardial infarction30.0NPPA, HTR2A, ADIPOQ, NPPB, AGT, NOS3
32atherosclerosis30.0ADIPOQ, AGT, NOS3, LEP
33essential hypertension29.1HTR2A, ADIPOQ, HSPA1A, LEP, NOS3, NPPA
34hypersomnia10.7
35endotheliitis10.7
36hypoxia10.7
37sleep disorder10.6
38neuropathy10.6
39pharyngitis10.6
40laryngomalacia10.6
41achondroplasia10.6
42mitral valve disease10.5NPPA
43sick sinus syndrome10.5NPPA
44craniosynostosis10.5
45acromegaly10.5
46cerebritis10.5
47headache10.5
48adiponectin deficiency10.5ADIPOQ
49periodic limb movement disorder10.5
50patent foramen ovale10.5

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to sleep apnea

Symptoms for Sleep Apnea

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Drugs & Therapeutics for Sleep Apnea

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Drug clinical trials:

Search ClinicalTrials for Sleep Apnea

Search NIH Clinical Center for Sleep Apnea

Genetic Tests for Sleep Apnea

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Anatomical Context for Sleep Apnea

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MalaCards organs/tissues related to Sleep Apnea:

32
Heart, Lung, Tonsil, Endothelial, Brain, Kidney, Testes, Bone, Liver, Eye, Ovary, Monocytes, Tongue, Bone marrow, Whole blood, Adipocyte, Thyroid, Breast, Skin, T cells, Neutrophil

Animal Models for Sleep Apnea or affiliated genes

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MGI Mouse Phenotypes related to Sleep Apnea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9AGT, LEP, NOS3, ADIPOQ
2MP:00053888.4KCNK3, KCNK9, HCRT, LEP, ADIPOQ, NOS3
3MP:00053798.3NOS3, KCNK9, KCNK3, LEP, ADIPOQ, HTR2A
4MP:00053678.2NPPA, AGT, NOS3, ADIPOQ, LEP, KCNMB1
5MP:00053868.0HCRT, AGT, NOS3, HTR2A, ADIPOQ, LEP
6MP:00053697.4LEP, AGT, NPPB, NPPA, NOS3, KCNMB1
7MP:00036317.3LEP, AGT, HCRT, KCNK9, KCNK3, NOS3
8MP:00053767.1KCNK3, KCNK9, HCRT, LEP, HSPA1A, ADIPOQ
9MP:00053856.3KCNK9, KCNK3, KCNMB1, HCRT, LEP, HSPA1A

Publications for Sleep Apnea

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Articles related to Sleep Apnea:

(show top 50)    (show all 1314)
idTitleAuthorsYear
1
Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea: A systematic review and meta-analysis. (25389029)
2014
2
Functional Comorbidity Index in Sleep Apnea. (24395621)
2014
3
Association of glucose transporter 4 genetic Polymorphisms with obstructive sleep apnea syndrome in Han Chinese general population: a cross-section study. (24410986)
2014
4
Upper Airway Stimulation for Obstructive Sleep Apnea: Past, Present, and Future. (25409109)
2014
5
Assessment of the effect of bariatric surgery on obstructive sleep apnea at two postoperative intervals. (23856989)
2014
6
Obstructive sleep apnea. (25364899)
2014
7
The evaluation of body composition, adiponectin, C-reactive protein and cholesterol levels in patients with obstructive sleep apnea syndrome. (24431310)
2013
8
Lipopolysaccharide-Binding Protein Plasma Levels in Children: Effects of Obstructive Sleep Apnea and Obesity. (24276451)
2013
9
Positive airway pressure therapy in patients with opioid-related central sleep apnea. (24062011)
2013
10
Letter regarding the review by Zhang et al. of portable recording for the diagnosis of obstructive sleep apnea in commercial motor vehicle drivers. (23904687)
2013
11
Sleep apnea-hypopnea syndrome and multiple symmetrical lipomatosis. (22974765)
2013
12
Obstructive sleep apnea as a risk factor after shoulder arthroplasty. (24045126)
2013
13
Executive dysfunction in children affected by obstructive sleep apnea syndrome: an observational study. (23976855)
2013
14
Effect of Qingxuan Granule () on blood pressure variability of hypertensive patients with and without obstructive sleep apnea. (24126974)
2013
15
Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. (22924163)
2013
16
Automated detection of sleep apnea in infants using minimally invasive sensors. (24110021)
2013
17
Obstructive sleep apnea (OSA) in preadolescent girls is associated with delayed breast development compared to girls without OSA. (23946712)
2013
18
Palatal sensory threshold reflects nocturnal hypoxemia and airway occlusion in snorers and obstructive sleep apnea patients. (24235900)
2013
19
Effectiveness of three sleep apnea management alternatives. (24293754)
2013
20
Motivational enhancement to improve adherence to positive airway pressure in patients with obstructive sleep apnea: a randomized controlled trial. (24179298)
2013
21
Obstructive sleep apnea does not promote esophageal reflux in fibrosing interstitial lung disease. (22521226)
2012
22
Late-onset laryngomalacia: a cause of pediatric obstructive sleep apnea. (21115204)
2011
23
Bilateral central serous chorioretinopathy resolving rapidly with treatment for obstructive sleep apnea. (20049474)
2010
24
Obstructive sleep apnea among patients with retinal vein occlusion. (21149775)
2010
25
Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome]. (20367952)
2010
26
Central sleep apnea. (20488284)
2010
27
Patent foramen ovale and obstructive sleep apnea: a new association? (20451427)
2010
28
Risk factors for obstructive sleep apnea syndrome screening in mood disorder patients. (19566771)
2009
29
Validity and reliability of Sleep Quality Scale in subjects with obstructive sleep apnea syndrome. (19073298)
2009
30
Central sleep apnea in patients with congestive heart failure. (18758947)
2009
31
Idiopathic intracranial hypertension in men and the relationship to sleep apnea. (18923134)
2009
32
Role of continuous positive airway pressure therapy on the pathogenesis of sleep-related frontal lobe epilepsy in a child with obstructive sleep apnea syndrome. (18079319)
2008
33
Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP). (18780208)
2008
34
Increased low-grade inflammation and plasminogen-activator inhibitor-1 level in nondippers with sleep apnea syndrome. (18475156)
2008
35
Serum angiotensin converting enzyme and the obstructive sleep apnea hypopnea syndrome. (18763423)
2008
36
Obstructive sleep apnea in patients with central serous chorioretinopathy. (18546012)
2008
37
Treating central sleep apnea in heart failure: outcomes revisited. (17592088)
2007
38
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. (16839844)
2006
39
Effects of nasal continuous positive airway pressure short-term treatment on C-reactive protein and intercellular adhesion molecule-1 in patients with obstructive sleep apnea-hypopnea syndrome]. (16708805)
2005
40
Undiagnosed obstructive sleep apnea syndrome in children with syndromal craniofacial synostosis. (15213550)
2004
41
Idiopathic edema is associated with obstructive sleep apnea in women. (15511705)
2004
42
Pembrey's dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. (12576341)
2003
43
Primary pulmonary hypertension with central sleep apnea: sudden death after bilevel positive airway pressure therapy. (10981861)
2000
44
Obstructive sleep apnea in children with achondroplasia: surgical and anesthetic considerations. (9949360)
1999
45
Central sleep apnea after interrupting longterm acetazolamide therapy. (9696283)
1998
46
Continuous versus bilevel positive airway pressure in a patient with idiopathic central sleep apnea. (9105099)
1997
47
Relationship of nasal continuous positive airway pressure to periodic limb movement disorder in a patient without sleep apnea. (8486056)
1993
48
Nasal continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea in Hallermann-Streiff syndrome. (2406080)
1990
49
Achondroplasia and obstructive sleep apnea: correction of apnea and abnormal sleep-entrained growth hormone release by tracheostomy. (4041579)
1985
50
Achondroplasia associated with obstructive sleep apnea. (6625996)
1983

Variations for Sleep Apnea

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Expression for genes affiliated with Sleep Apnea

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Expression patterns in normal tissues for genes affiliated with Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for genes affiliated with Sleep Apnea

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Pathways related to Sleep Apnea according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NPPB, NPPA
2
Show member pathways
9.5NOS3, AGT
3
Show member pathways
9.5HCRT, HTR2A, AGT
4
Show member pathways
9.4NOS3, KCNMB1
59.4AGT, ADIPOQ, LEP
6
Show member pathways
9.4AGT, ADIPOQ, LEP
79.4NPPA, NPPB, AGT
8
Show member pathways
9.3NOS3, HSPA1A
9
Show member pathways
9.3AGT, HTR2A, LEP, HCRT
10
Show member pathways
9.2KCNMB1, KCNK3, KCNK9
11
Show member pathways
9.1HSPA1A, KCNK3, KCNK9
12
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.7NPPB, NOS3, HTR2A, HSPA1A

Compounds for genes affiliated with Sleep Apnea

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Compounds related to Sleep Apnea according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1rimonabant44 28 1111.9HCRT, ADIPOQ, LEP
2oxyntomodulin44 6110.8ADIPOQ, LEP, HCRT
3hanp449.8NPPB, NPPA, ADIPOQ
4ramipril44 1110.8NPPB, NPPA, ADIPOQ
5enalaprilat449.8NPPA, AGT, NPPB
6lisinopril44 50 24 1112.7AGT, NPPA, NPPB
78-bromo cgmp449.7NPPB, AGT, NPPA
8atenolol44 50 28 24 1113.7NPPB, LEP, AGT
9valsartan44 61 28 1112.7ADIPOQ, AGT, NPPB
10c-peptide449.5HCRT, LEP, ADIPOQ, AGT
11telmisartan44 28 1111.5AGT, NPPB, ADIPOQ, LEP
12n(g)-nitro-l-arginine methyl ester449.5AGT, NOS3, LEP
13enalapril44 50 1111.4AGT, NPPA, ADIPOQ, NPPB
14metoprolol44 50 28 24 1113.3NPPB, ADIPOQ, NPPA, NOS3
15aminoguanidine44 28 1111.3NOS3, HSPA1A, LEP
16pravastatin44 50 28 24 1113.3NPPB, ADIPOQ, LEP, NOS3
17perindopril44 50 1111.3AGT, NOS3, NPPA, NPPB
18haloperidol44 50 28 2 1113.3AGT, NPPB, HTR2A, HCRT, NPPA
19ang ii449.3NPPA, NOS3, AGT, NPPB
20candesartan44 50 28 1112.2AGT, NOS3, ADIPOQ, NPPB
21ng-nitro-l-arginine449.2NOS3, AGT, NPPA
22losartan44 50 28 1112.2AGT, LEP, ADIPOQ, NPPA, NPPB
23guanylate449.2NPPB, NPPA, NOS3, AGT
24homocysteine44 2410.1NPPB, AGT, NOS3, ADIPOQ
25rosiglitazone28 44 50 24 1113.1NPPB, ADIPOQ, LEP, NOS3
26sodium nitroprusside449.1NPPA, LEP, ADIPOQ, NOS3, NPPB
27l-nmma449.1LEP, NOS3, NPPA, NPPB, AGT
28atorvastatin44 50 28 24 1113.0ADIPOQ, NOS3, NPPB, AGT
29nifedipine44 28 50 1112.0LEP, ADIPOQ, NPPA, AGT
30amlodipine44 50 24 1112.0AGT, NPPA, NPPB, NOS3, ADIPOQ
31estradiol44 24 1110.9ADIPOQ, HCRT, AGT, NPPB, LEP
32dopamine44 28 24 1111.9HCRT, ADIPOQ, NPPA, NPPB, AGT, HTR2A
33phenylephrine44 28 24 1111.8NPPA, NOS3, LEP, HCRT, AGT, NPPB
348-isoprostane448.8LEP, NPPB, NOS3, ADIPOQ, HSPA1A
35thapsigargin44 619.8NOS3, ADIPOQ, HSPA1A, HCRT, NPPB
36acetylcholine44 50 28 24 1112.7NPPB, ADIPOQ, HCRT, LEP, AGT, NOS3
37epinephrine44 24 1110.7AGT, NPPB, NPPA, HSPA1A, LEP, HCRT
38prostacyclin448.7LEP, ADIPOQ, NOS3, NPPA, AGT, NPPB
39sb 20358044 619.6ADIPOQ, HSPA1A, NOS3, NPPB, AGT
40dexamethasone44 50 28 1111.5HSPA1A, HCRT, AGT, NPPB, ADIPOQ, LEP
41creatinine448.5LEP, AGT, NPPB, NPPA, ADIPOQ, HSPA1A
42cyclosporin a44 28 6110.5LEP, NPPA, NPPB, AGT, HSPA1A
43actinomycin d448.5AGT, HSPA1A, ADIPOQ, NOS3, NPPB
44estrogen448.1NPPB, HCRT, NPPA, NOS3, ADIPOQ, HSPA1A
45nitric oxide44 24 1110.1AGT, NPPB, NPPA, NOS3, HSPA1A, HCRT
46norepinephrine44 24 1110.1HTR2A, NPPA, NPPB, AGT, HSPA1A, ADIPOQ
47potassium44 24 1110.0NPPA, AGT, HSPA1A, HCRT, KCNK9, KCNMB1
48glutamate448.0ADIPOQ, LEP, KCNK3, HCRT, NOS3, KCNK9
49arginine447.7KCNK3, NOS3, ADIPOQ, HSPA1A, LEP, NPPA
50calcium44 50 24 1110.1AGT, HSPA1A, KCNK9, KCNMB1, HTR2A, NOS3

GO Terms for genes affiliated with Sleep Apnea

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Cellular components related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8AGT, NPPB, NPPA, ADIPOQ, LEP
2extracellular regionGO:0055768.2AGT, HCRT, LEP, ADIPOQ, NPPA, NPPB

Biological processes related to Sleep Apnea according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.1NPPB, NPPA
2artery smooth muscle contractionGO:01482410.1HTR2A, AGT
3receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
4ovulation from ovarian follicleGO:00154210.0LEP, NOS3
5eating behaviorGO:04275510.0LEP, HCRT
6positive regulation of cellular protein metabolic processGO:0322709.9AGT, ADIPOQ
7positive regulation of renal sodium excretionGO:0358159.9NPPB, AGT
8cochlea developmentGO:0901029.9KCNK3, KCNK9
9positive regulation of cytokine productionGO:0018199.9AGT, LEP
10phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.8AGT, HCRT
11negative regulation of potassium ion transportGO:0432679.7HCRT, HTR2A, NOS3
12nitric oxide mediated signal transductionGO:0072639.7AGT, NOS3
13response to hypoxiaGO:0016669.6LEP, ADIPOQ, NPPA
14negative regulation of cell growthGO:0303089.6AGT, NPPB, NPPA
15regulation of blood vessel sizeGO:0508809.6NPPB, NPPA, NOS3
16potassium ion transportGO:0068139.5KCNMB1, KCNK3, KCNK9
17negative regulation of blood pressureGO:0457769.5ADIPOQ, NOS3
18regulation of blood pressureGO:0082179.4NPPB, NPPA, NOS3, LEP
19blood vessel remodelingGO:0019749.2AGT, NOS3
20synaptic transmissionGO:0072689.0KCNK9, KCNK3, KCNMB1, HCRT, HTR2A

Molecular functions related to Sleep Apnea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone receptor bindingGO:0514289.8NPPA, LEP
2receptor bindingGO:0051029.4ADIPOQ, NPPA, NPPB
3potassium channel activityGO:0052679.4KCNK3, KCNK9
4hormone activityGO:0051798.8ADIPOQ, LEP, AGT, NPPB, NPPA

Products for genes affiliated with Sleep Apnea

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Sources for Sleep Apnea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet