Aliases & Classifications for Sleep Apnea

Aliases & Descriptions for Sleep Apnea:

Name: Sleep Apnea 12 51 29 41 14
Sleep Apnea Syndromes 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050847

Summaries for Sleep Apnea

NINDS : 51 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.  These episodes usually last 10 seconds or more and occur repeatedly throughout the night.  People with sleep apnea will partially awaken as they struggle to breathe, but in the morning they will not be aware of the disturbances in their sleep.  The most common type of sleep apnea is obstructive sleep apnea (OSA), caused by relaxation of soft tissue in the back of the throat that blocks the passage of air.  Central sleep apnea (CSA) is caused by irregularities in the brain’s normal signals to breathe.  Most people with sleep apnea will have a combination of both types.  The hallmark symptom of the disorder is excessive daytime sleepiness. Additional symptoms of sleep apnea include restless sleep, loud snoring (with periods of silence followed by gasps), falling asleep during the day, morning headaches, trouble concentrating, irritability, forgetfulness, mood or behavior changes, anxiety, and depression.  Not everyone who has these symptoms will have sleep apnea, but it is recommended that people who are experiencing even a few of these symptoms visit their doctor for evaluation.  Sleep apnea is more likely to occur in men than women, and in people who are overweight or obese.

MalaCards based summary : Sleep Apnea, also known as sleep apnea syndromes, is related to neuropathy and ischemic optic neuropathy, and has symptoms including back pain, cheyne-stokes respiration and coughing. An important gene associated with Sleep Apnea is LEP (Leptin), and among its related pathways/superpathways are Signaling by GPCR and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Cafcit Injection and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

MedlinePlus : 41 sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils or adenoids may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

Wikipedia : 71 Sleep apnea, also spelled sleep apnoea, is a sleep disorder characterized by pauses in breathing or... more...

Related Diseases for Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 458)
id Related Disease Score Top Affiliating Genes
1 neuropathy 30.6 CRP CXCL8 IL6 TNF
2 ischemic optic neuropathy 30.5 ACE CRP HTR2A IL6
3 nasopharyngitis 30.2 CXCL8 IL6 TNF
4 choroiditis 29.6 ACE CRP CXCL8 IL6 TNF
5 lipomatosis 29.5 ACE ADIPOQ APOE CRP INS LEP
6 myocardial infarction 28.9 ACE ADIPOQ APOE CRP EDN1 ICAM1
7 adrenal adenoma 28.8 ADIPOQ CRP GHRL IGF1 IL6 INS
8 obstructive sleep apnea 12.6
9 central sleep apnea 12.6
10 glaucoma and sleep apnea 12.1
11 autoimmune encephalopathy with parasomnia and obstructive sleep apnea 12.0
12 obesity 11.3
13 hypersomnia 11.3
14 sleep disorder 11.2
15 acromegaly 11.2
16 polycystic ovary syndrome 11.2
17 idiopathic alveolar hypoventilation syndrome 11.2
18 xia-gibbs syndrome 11.0
19 central hypoventilation syndrome, congenital 11.0
20 bohring-opitz syndrome 10.9
21 histiocytosis-lymphadenopathy plus syndrome 10.9
22 postpoliomyelitis syndrome 10.9
23 lupus erythematosus panniculitis 10.4 ACE APOE
24 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.4 IL6 TNF
25 swine influenza 10.4 CRP IL6 TNF
26 preaxial polydactyly of fingers 10.4 ACE IL6 TNF
27 human immunodeficiency virus infectious disease 10.3 CRP IL6 TNF
28 mucinoses 10.3 ADIPOQ IL6 LEP
29 nystagmus, congenital motor, autosomal recessive 10.3 ADIPOQ LEP TNF
30 secretory diarrhea myopathy and deafness 10.3 ACE CRP IL6
31 benign neonatal seizures 10.3 CRP IL6 TNF
32 lupus erythematosus 10.3 ACE CRP IL6
33 iron metabolism disease 10.3 ACE APOE CRP
34 autoimmune disease of central nervous system 10.3 CRP IL6 TNF
35 plummer's disease 10.3 CRP IL6 TNF
36 hematocele of tunica vaginalis testis 10.3 ADIPOQ EDN1 TNF
37 neurotic disorder 10.3 ICAM1 LEP TNF
38 tuberculosis 10.3 ACE IL6 TNF
39 conduct disorder 10.3 ICAM1 IL6 TNF
40 follicular adenoma 10.3 CRP IL6 TNF
41 central nervous system lymphoma 10.3 EDN1 IL6 TNF
42 carotenemia 10.3 CRP IL6 TNF
43 proliferating trichilemmal cyst 10.3 EDN1 NOS3
44 dermatomycosis 10.3 CRP ICAM1 TNF
45 hypotrichosis simplex 10.3 ACE REN
46 rift valley fever 10.3 CRP IL6 TNF
47 congestive heart failure 10.3
48 villous adenoma 10.3 ACE CRP NOS3
49 aplasia cutis congenita recessive 10.3 ACE EDN1 NOS3
50 acute infection of pinna 10.3 CRP INS

Comorbidity relations with Sleep Apnea via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Pulmonary Hypertension, Familial Primary, 1, with or Without Hht
Respiratory Failure

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to Sleep Apnea

Symptoms & Phenotypes for Sleep Apnea

UMLS symptoms related to Sleep Apnea:


back pain, cheyne-stokes respiration, coughing, dyspnea, headache, pain, sciatica, seizures, sleep disturbances, snoring, syncope, tremor, wheezing, chronic pain, vertigo/dizziness, labored breathing, excessive daytime somnolence, sleeplessness, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Sleep Apnea:

44 (show all 21)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 REN TNF ACE ADIPOQ APOE CRP
2 homeostasis/metabolism MP:0005376 10.44 REN TNF ACE ADIPOQ APOE CRP
3 endocrine/exocrine gland MP:0005379 10.41 ACE ADIPOQ APOE EDN1 GHRL HTR2A
4 behavior/neurological MP:0005386 10.4 LEP LEPR NOS3 REN TNF ACE
5 growth/size/body region MP:0005378 10.4 ACE ADIPOQ APOE EDN1 HCRT ICAM1
6 adipose tissue MP:0005375 10.34 ACE ADIPOQ APOE GHRL IGF1 IL6
7 immune system MP:0005387 10.34 ACE ADIPOQ APOE CRP ICAM1 IGF1
8 hematopoietic system MP:0005397 10.33 LEP LEPR NOS3 REN TNF ACE
9 digestive/alimentary MP:0005381 10.32 APOE EDN1 GHRL HTR2A ICAM1 IL6
10 muscle MP:0005369 10.3 ADIPOQ APOE EDN1 HCRT HTR2A ICAM1
11 mortality/aging MP:0010768 10.29 ACE ADIPOQ APOE EDN1 ICAM1 IGF1
12 nervous system MP:0003631 10.18 APOE EDN1 HCRT ICAM1 IGF1 IL6
13 integument MP:0010771 10.16 ICAM1 IGF1 IL6 INS LEP LEPR
14 liver/biliary system MP:0005370 10.15 ACE ADIPOQ APOE IL6 INS LEP
15 renal/urinary system MP:0005367 10.06 ADIPOQ ACE LEPR NOS3 REN APOE
16 neoplasm MP:0002006 10.03 ACE ADIPOQ ICAM1 IGF1 IL6 LEP
17 reproductive system MP:0005389 9.96 ACE APOE IGF1 IL6 INS LEP
18 respiratory system MP:0005388 9.81 ADIPOQ APOE HCRT IGF1 IL6 LEP
19 skeleton MP:0005390 9.7 ADIPOQ APOE EDN1 HTR2A IGF1 IL6
20 obsolete other MP:0005395 9.54 ADIPOQ LEPR NOS3
21 vision/eye MP:0005391 9.23 LEPR NOS3 TNF APOE ICAM1 IL6

Drugs & Therapeutics for Sleep Apnea

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cafcit Injection 17 CAFFEINE CITRATE Roxane Laboratories Approved September 1999

Drugs for Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 450)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 4 120014-06-4 3152
2
Budesonide Approved Phase 4,Phase 3,Phase 1 51333-22-3 63006 5281004
3
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
4
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
5
Clonidine Approved Phase 4 4205-90-7 2803
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7
Nitric Oxide Approved Phase 4 10102-43-9 145068
8
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
9
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
10
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2 59-66-5 1986
11
Remifentanil Approved Phase 4,Phase 1,Early Phase 1 132875-61-7 60815
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 437-38-7 3345
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
14
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
15
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2 2216-51-5 16666
16
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
17
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
18
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
19
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
20
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
21
Adalimumab Approved Phase 4 331731-18-1 16219006
22
Mannitol Approved, Investigational Phase 4,Phase 2,Phase 3 69-65-8 453 6251
23
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
24
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
25
Sodium oxybate Approved Phase 4 502-85-2 5360545
26
Zolpidem Approved Phase 4 82626-48-0 5732
27
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
28
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
29
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
30
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
32
Ephedrine Approved Phase 4 299-42-3 9294
33
Pseudoephedrine Approved Phase 4 90-82-4 7028
34
Xylometazoline Approved Phase 4 526-36-3 5709
35
Losartan Approved Phase 4,Phase 2 114798-26-4 3961
36
Eszopiclone Approved Phase 4,Phase 2,Early Phase 1 138729-47-2 969472
37
Norepinephrine Approved Phase 4 51-41-2 439260
38
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
39
Pantoprazole Approved Phase 4 102625-70-7 4679
40
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
41
Olanzapine Approved, Investigational Phase 4,Phase 1 132539-06-1 4585
42
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
43
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
44
Desflurane Approved Phase 4 57041-67-5 42113
45
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
46
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
47
Cocaine Approved, Illicit Phase 4 50-36-2 5760 446220
48
Dopamine Approved Phase 4,Phase 1 51-61-6, 62-31-7 681
49
Trazodone Approved, Investigational Phase 4,Phase 1,Early Phase 1 19794-93-5 5533
50
Zopiclone Approved Phase 4,Phase 3 43200-80-2 5735

Interventional clinical trials:

(show top 50) (show all 1640)
id Name Status NCT ID Phase
1 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
2 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4
3 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
4 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
5 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Unknown status NCT00560586 Phase 4
6 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
7 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
8 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Unknown status NCT01699126 Phase 4
9 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
10 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
11 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
12 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4
13 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
14 Treatment of Cheyne Stocks Respiration With Adaptive Servo Ventilation and Bilevel Ventilators in Patients With Chronic Heart Failure Unknown status NCT00725595 Phase 4
15 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4
16 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
17 Resistant Hypertension Optimal Treatment Unknown status NCT01643434 Phase 4
18 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
19 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
20 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4
21 Sleep Apnea and Oxidative Stress and Nitric Oxide Completed NCT00547937 Phase 4
22 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome Completed NCT01635010 Phase 4
23 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4
24 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4
25 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
26 Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea Completed NCT02160223 Phase 4
27 Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients Completed NCT00741520 Phase 4
28 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed NCT02264353 Phase 4
29 Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea Completed NCT01945801 Phase 4
30 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients Completed NCT00708786 Phase 4
31 Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea Completed NCT00772044 Phase 4
32 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4
33 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children Completed NCT00912171 Phase 4
34 Sleep Apnea. Concordance Between Non-reference and Reference Centres Completed NCT00424658 Phase 4
35 Nasal Decongestion and Obstructive Sleep Apnea Completed NCT00630474 Phase 4
36 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4
37 Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment Completed NCT00701428 Phase 4
38 Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude Completed NCT00928655 Phase 4
39 Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment Completed NCT00400543 Phase 4
40 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
41 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4
42 Effect of Continuous Positive Airway Pressure (CPAP) on Hypertension and Cardiovascular Morbidity-Mortality in Patients With Sleep Apnea and no Daytime Sleepiness Completed NCT00127348 Phase 4
43 CPAP in Diabetes Type 2 Patients With Sleep Apnea Completed NCT01801150 Phase 4
44 Continuous Positive Airway Pressure (CPAP) Treatment in Coronary Artery Disease and Sleep Apnea Completed NCT00519597 Phase 4
45 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4
46 Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome Completed NCT01508754 Phase 4
47 Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients Completed NCT00729963 Phase 4
48 Automate Detection of Sleep Apnea by ApneascanTM Completed NCT02045173 Phase 4
49 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
50 Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP) Completed NCT00612157 Phase 4

Search NIH Clinical Center for Sleep Apnea

Genetic Tests for Sleep Apnea

Genetic tests related to Sleep Apnea:

id Genetic test Affiliating Genes
1 Sleep Apnea 29

Anatomical Context for Sleep Apnea

MalaCards organs/tissues related to Sleep Apnea:

39
Heart, Brain, Lung, Tonsil, Endothelial, Kidney, Liver

Publications for Sleep Apnea

Articles related to Sleep Apnea:

(show top 50) (show all 1610)
id Title Authors Year
1
Vascular endothelial growth factor levels in patients with obstructive sleep apnea: a meta-analysis. ( 27236786 )
2017
2
Obstructive sleep apnea risk and leukocyte telomere length in African Americans from the MH-GRID study. ( 28083855 )
2017
3
Pacemaker-detected severe sleep apnea predicts new-onset atrial fibrillation. ( 28073884 )
2017
4
Corrigendum to "Screening, diagnosis, and management of obstructive sleep apnea in dangerous-goods truck drivers: to be aware or not?" [Sleep Med. 2016;25:98-104]. ( 28057498 )
2017
5
In Patients with Vascular Disease, Treating Sleep Apnea Does Not Reduce the Risk of Cardiovascular Events. ( 28084709 )
2017
6
The Efficacy of Adenotonsillectomy for Obstructive Sleep Apnea in Children with Down Syndrome: A Systematic Review. ( 28485249 )
2017
7
Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial on psychological distress. ( 28083705 )
2017
8
Corrigendum to "Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome" [Sleep Med 27-28 (2016) 99-106]. ( 28457800 )
2017
9
Increased prevalence of obstructive sleep apnea in patients with Cushing's syndrome compared with weight- and age-matched controls. ( 27932409 )
2017
10
Single Nucleotide Polymorphisms in Adiponectin Gene Are Not Directly Associated with Increased Risk of Obstructive Sleep Apnea Syndrome in a Chinese Han Population. ( 28068661 )
2017
11
Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy. ( 28081532 )
2017
12
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
13
Effect of jaw-opening exercise on prevention of temporomandibular disorders pain associated with oral appliance therapy in obstructive sleep apnea patients: A randomized, double-blind, placebo-controlled trial. ( 28063976 )
2017
14
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea. ( 28078488 )
2017
15
Correlation between Calpain-10 single-nucleotide polymorphisms and obstructive sleep apnea/hypopnoea syndrome with ischemic stroke in a Chinese population: A population-based study. ( 28422847 )
2017
16
Gray Matter Hypertrophy and Thickening with Obstructive Sleep Apnea in Middle-aged and Older Adults. ( 28060546 )
2017
17
Maxillary Expansion and Mandibular Setback Surgery With and Without Mandibular Anterior Segment Osteotomy to Correct Mandibular Prognathism With Obstructive Sleep Apnea. ( 28060088 )
2017
18
Investigation of the link between fluid shift and airway collapsibility as a mechanism for obstructive sleep apnea in congestive heart failure. ( 28057850 )
2017
19
The effect of early fusion of the spheno-occipital synchondrosis on midface hypoplasia and obstructive sleep apnea in patients with Crouzon syndrome. ( 28479031 )
2017
20
Exploiting temporal and nonstationary features in breathing sound analysis for multiple obstructive sleep apnea severity classification. ( 28086902 )
2017
21
Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea. ( 27321703 )
2017
22
Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene. ( 28514291 )
2017
23
Epidemiological characteristics and gender-specific differences of obstructive sleep apnea in a Chinese hypertensive population: a cross-sectional study. ( 28056799 )
2017
24
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. ( 28358591 )
2017
25
Bone Age and Serum Osteocalcin Levels in Children With Obstructive Sleep Apnea Hypopnea Syndrome Before and After Adenotonsillectomy. ( 26938749 )
2017
26
New Uses for Old Biomarkers in chronic obstructive pulmonar disease and Obstructive Sleep Apnea? ( 28089428 )
2017
27
Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome. ( 27754829 )
2017
28
Urinary biomarkers and obstructive sleep apnea in patients with Down syndrome. ( 28522103 )
2017
29
Adenotonsillectomy outcomes in patients with Down syndrome and obstructive sleep apnea. ( 28055122 )
2017
30
Influence of smoking on sleep and obstructive sleep apnea syndrome. ( 27209838 )
2016
31
Medium Increased Risk for Central Sleep Apnea but Not Obstructive Sleep Apnea in Long-Term Opioid Users: A Systematic Review and Meta-Analysis. ( 26943709 )
2016
32
Data-Driven Multimodal Sleep Apnea Events Detection : Synchrosquezing Transform Processing and Riemannian Geometry Classification Approaches. ( 27194241 )
2016
33
Continuous positive airway pressure and survival of very elderly persons with moderate to severe obstructive sleep apnea. ( 27198943 )
2016
34
Serum Thymosin I^4 Concentrations in Obstructive Sleep Apnea Syndrome Patients. ( 27086675 )
2016
35
Clinical predictors of central sleep apnea evoked by positive airway pressure titration. ( 27555802 )
2016
36
Characterization of obstructive sleep apnea-hypopnea syndrome (OSA) population by means of cluster analysis. ( 27191534 )
2016
37
Drop episodes improved after tracheotomy: a case of Coffin-Lowry syndrome associated with obstructive sleep apnea syndrome. ( 26914125 )
2016
38
Severe Central Sleep Apnea Associated WithA Chronic Baclofen Therapy: A Case Series. ( 27157226 )
2016
39
Relationship between chronic kidney disease and central sleep apnea: the importance of volume management. ( 27638723 )
2016
40
Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome. ( 26930634 )
2016
41
Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis. ( 27198559 )
2016
42
Utility of the Pediatric Sleep Questionnaire and Urocortin Level in Urine as Screening Tools in Pediatric Patients with Suspected Obstructive Sleep Apnea Syndrome. ( 27648432 )
2016
43
A systematic review on prevalence and risk factors associated with treatment- emergent central sleep apnea. ( 27512510 )
2016
44
Central Sleep Apnea at High Altitude. ( 27343103 )
2016
45
Unanticipated Nocturnal Oxygen Requirement During Positive Pressure Therapy for Sleep Apnea and Medical Comorbidities. ( 27655454 )
2016
46
End-Tidal CO2 Tension Is Predictive of Effective Nocturnal Oxygen Therapy in Patients with Chronic Heart Failure and Central Sleep Apnea. ( 27169493 )
2016
47
Novel Therapies for the Treatment of Central Sleep Apnea. ( 27236059 )
2016
48
Current treatment approaches and trials in central sleep apnea. ( 26961738 )
2016
49
Serum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome. ( 27206623 )
2016
50
Mandibular Advancement Appliance for Obstructive Sleep Apnea Treatment. ( 27645538 )
2016

Variations for Sleep Apnea

ClinVar genetic disease variations for Sleep Apnea:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 AHDC1 NM_001029882.3(AHDC1): c.2373_2374delTG (p.Cys791Trpfs) deletion Pathogenic rs587779766 GRCh37 Chromosome 1, 27876253: 27876254
2 AHDC1 NM_001029882.3(AHDC1): c.2898delC (p.Tyr967Thrfs) deletion Pathogenic rs587779767 GRCh37 Chromosome 1, 27875729: 27875729
3 AHDC1 NM_001029882.3(AHDC1): c.2547delC (p.Ser850Profs) deletion Pathogenic rs587779768 GRCh37 Chromosome 1, 27876080: 27876080

Expression for Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for Sleep Apnea

Pathways related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 39)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 APOE CXCL8 EDN1 GHRL HCRT HTR2A
2
Show member pathways
13.46 ADIPOQ APOE CXCL8 IL6 INS LEP
3
Show member pathways
12.41 ADIPOQ IGF1 INS LEP LEPR
4
Show member pathways
12.29 APOE CRP ICAM1 IL6 INS TNF
6
Show member pathways
12.19 ACE IGF1 IL6 TNF
7 12.16 CXCL8 HTR2A IL6 TNF
8
Show member pathways
12.13 EDN1 IGF1 NPPB TNF
9
Show member pathways
12.11 ACE GHRL IGF1 INS LEP REN
10 12.07 EDN1 ICAM1 NOS3 TNF
11 11.97 CXCL8 ICAM1 IL6 LEP TNF
12 11.96 CXCL8 ICAM1 IL6 TNF
13
Show member pathways
11.93 IL6 INS NOS3 TNF
14 11.92 EDN1 ICAM1 IL6 TNF
15 11.9 CXCL8 IGF1 IL6 INS
16 11.85 EDN1 IGF1 IL6 INS NOS3
17 11.82 CXCL8 ICAM1 IL6 TNF
18 11.81 ADIPOQ IGF1 IL6 INS LEP
19
Show member pathways
11.76 ACE NOS3 REN
20 11.73 CXCL8 IL6 TNF
21 11.7 ADIPOQ LEP LEPR TNF
22 11.69 ICAM1 IL6 TNF
23
Show member pathways
11.65 CXCL8 ICAM1 IL6 TNF
24 11.57 CXCL8 IL6 INS
25 11.57 CXCL8 IL6 TNF
26 11.55 ADIPOQ IGF1 IL6 INS LEP TNF
27 11.53 CXCL8 ICAM1 IL6 TNF
28 11.52 INS LEP LEPR
29 11.52 CXCL8 ICAM1 IL6 TNF
30 11.49 ICAM1 IL6 TNF
31 11.49 IGF1 IL6 INS
32 11.46 APOE IGF1 IL6 TNF
33 11.45 CXCL8 EDN1 IGF1 IL6 TNF
34 11.34 ICAM1 IL6 TNF
35 11.32 CXCL8 IL6 NOS3
36
Show member pathways
11.18 CRP EDN1 LEP LEPR
37 11.1 CXCL8 EDN1 ICAM1 IL6 NOS3 TNF
38 10.97 ADIPOQ IL6 LEP TNF
39 10.74 CRP CXCL8 IL6 TNF