Aliases & Classifications for Sleep Apnea

MalaCards integrated aliases for Sleep Apnea:

Name: Sleep Apnea 12 51 29 41 14
Sleep Apnea Syndromes 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050847

Summaries for Sleep Apnea

NINDS : 51 Sleep apnea is a common sleep disorder characterized by brief interruptions of breathing during sleep.  These episodes usually last 10 seconds or more and occur repeatedly throughout the night.  People with sleep apnea will partially awaken as they struggle to breathe, but in the morning they will not be aware of the disturbances in their sleep.  The most common type of sleep apnea is obstructive sleep apnea (OSA), caused by relaxation of soft tissue in the back of the throat that blocks the passage of air.  Central sleep apnea (CSA) is caused by irregularities in the brain’s normal signals to breathe.  Most people with sleep apnea will have a combination of both types.  The hallmark symptom of the disorder is excessive daytime sleepiness. Additional symptoms of sleep apnea include restless sleep, loud snoring (with periods of silence followed by gasps), falling asleep during the day, morning headaches, trouble concentrating, irritability, forgetfulness, mood or behavior changes, anxiety, and depression.  Not everyone who has these symptoms will have sleep apnea, but it is recommended that people who are experiencing even a few of these symptoms visit their doctor for evaluation.  Sleep apnea is more likely to occur in men than women, and in people who are overweight or obese.

MalaCards based summary : Sleep Apnea, also known as sleep apnea syndromes, is related to ischemic heart disease and craniosynostosis, and has symptoms including back pain, cheyne-stokes respiration and coughing. An important gene associated with Sleep Apnea is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Signaling by GPCR and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Cafcit Injection and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

MedlinePlus : 41 sleep apnea is a common disorder that causes your breathing to stop or get very shallow. breathing pauses can last from a few seconds to minutes. they may occur 30 times or more an hour. the most common type is obstructive sleep apnea. it causes your airway to collapse or become blocked during sleep. normal breathing starts again with a snort or choking sound. people with sleep apnea often snore loudly. however, not everyone who snores has sleep apnea. you are more at risk for sleep apnea if you are overweight, male, or have a family history or small airways. children with enlarged tonsils or adenoids may also get it. doctors diagnose sleep apnea based on medical and family histories, a physical exam, and sleep study results. when your sleep is interrupted throughout the night, you can be drowsy during the day. people with sleep apnea are at higher risk for car crashes, work-related accidents, and other medical problems. if you have it, it is important to get treatment. lifestyle changes, mouthpieces, surgery, and breathing devices can treat sleep apnea in many people. nih: national heart, lung, and blood institute

Disease Ontology : 12 A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep.

Wikipedia : 72 Sleep apnea, also spelled sleep apnoea, is a sleep disorder characterized by pauses in breathing or... more...

Related Diseases for Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 500)
id Related Disease Score Top Affiliating Genes
1 ischemic heart disease 30.9 ACE CRP HTR2A IL6
2 craniosynostosis 30.6 ACE EDN1 NPPB REN
3 dysphagia 30.5 CXCL8 ICAM1 IL6 TNF
4 pulmonary embolism 30.3 CRP CXCL8 IL6 TNF
5 angina pectoris 30.0 ACE CRP IL6
6 asthma 29.8 CXCL8 EDN1 ICAM1 IL6 LEP TNF
7 choroiditis 29.8 ACE CRP CXCL8 IL6 TNF
8 myocardial infarction 26.2 ACE ADIPOQ APOE CRP EDN1 GHRL
9 obstructive sleep apnea 12.6
10 central sleep apnea 12.5
11 glaucoma and sleep apnea 12.3
12 autoimmune encephalopathy with parasomnia and obstructive sleep apnea 12.0
13 hypersomnia 11.2
14 sleep disorder 11.2
15 acromegaly 11.2
16 polycystic ovary syndrome 11.2
17 idiopathic alveolar hypoventilation syndrome 11.0
18 xia-gibbs syndrome 11.0
19 smarca4-deficient sarcoma of thorax 11.0 IL6 TNF
20 autoimmune hemolytic anemia, warm type 11.0 ACE APOE
21 acquired hypoprothrombinemia 10.9 ADIPOQ LEP
22 collagenopathy type 2 alpha 1 10.9 CRP IL6
23 epstein-barr virus hepatitis 10.9 CRP IL6 TNF
24 potato nose 10.9 ACE IL6 TNF
25 alzheimer's disease 10 10.9 APOE HTR2A
26 not otherwise specified 3-mga-uria type 10.9 ADIPOQ LEP TNF
27 central nervous system leiomyosarcoma 10.9 CRP IL6 TNF
28 postpoliomyelitis syndrome 10.9
29 bohring-opitz syndrome 10.9
30 histiocytosis-lymphadenopathy plus syndrome 10.9
31 scleredema adultorum 10.9 ADIPOQ IL6 LEP
32 chronic diarrhea due to guanylate cyclase 2c overactivity 10.8 ACE CRP IL6
33 benign neonatal seizures 10.8 CRP IL6 TNF
34 ostertagiasis 10.8 ACE IL6 TNF
35 early congenital syphilis 10.8 CRP IL6 TNF
36 plummer's disease 10.8 CRP IL6 TNF
37 residual stage corticosteroid-induced glaucoma 10.8 CRP IL6 TNF
38 parasitic helminthiasis infectious disease 10.8 ACE CRP IL6
39 c1 inhibitor deficiency 10.8 CRP IL6 TNF
40 hematocele of tunica vaginalis testis 10.8 ADIPOQ EDN1 TNF
41 high pressure neurological syndrome 10.8 EDN1 IL6 TNF
42 chronic fungal otitis externa 10.8 CRP INS
43 spindle cell hemangioma 10.8 ICAM1 LEP TNF
44 iron metabolism disease 10.8 ACE APOE CRP
45 cornea cancer 10.8 CRP IL6 TNF
46 rift valley fever 10.8 CRP IL6 TNF
47 hypothyroidism due to iodide transport defect 10.8 ACE REN
48 dermatomycosis 10.8 CRP ICAM1 TNF
49 conduct disorder 10.8 ICAM1 IL6 TNF
50 intracranial arteriosclerosis 10.8 IL6 NPPB TNF

Comorbidity relations with Sleep Apnea via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Pulmonary Hypertension, Familial Primary, 1, with or Without Hht
Respiratory Failure

Graphical network of the top 20 diseases related to Sleep Apnea:



Diseases related to Sleep Apnea

Symptoms & Phenotypes for Sleep Apnea

UMLS symptoms related to Sleep Apnea:


back pain, cheyne-stokes respiration, coughing, dyspnea, headache, pain, sciatica, seizures, sleep disturbances, snoring, syncope, tremor, wheezing, chronic pain, vertigo/dizziness, labored breathing, excessive daytime somnolence, sleeplessness, insomnia with sleep apnea, unspecified, hypersomnia with sleep apnea, unspecified, disruption of 24 hour sleep wake cycle, unspecified

MGI Mouse Phenotypes related to Sleep Apnea:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.45 ACE ADIPOQ APOE CRP EDN1 HCRT
2 homeostasis/metabolism MP:0005376 10.43 ACE ADIPOQ APOE CRP EDN1 GHRL
3 behavior/neurological MP:0005386 10.4 ACE ADIPOQ APOE GHRL HCRT HTR2A
4 endocrine/exocrine gland MP:0005379 10.4 ADIPOQ APOE EDN1 GHRL HTR2A ICAM1
5 growth/size/body region MP:0005378 10.39 APOE EDN1 HCRT ICAM1 IGF1 IL6
6 adipose tissue MP:0005375 10.33 ACE ADIPOQ APOE GHRL IGF1 IL6
7 immune system MP:0005387 10.32 CRP ICAM1 IGF1 IL6 INS LEP
8 digestive/alimentary MP:0005381 10.31 APOE EDN1 GHRL HTR2A ICAM1 IL6
9 hematopoietic system MP:0005397 10.31 REN TNF ACE ADIPOQ APOE ICAM1
10 muscle MP:0005369 10.28 TNF ADIPOQ APOE EDN1 HCRT HTR2A
11 mortality/aging MP:0010768 10.27 ACE ADIPOQ APOE EDN1 ICAM1 IGF1
12 integument MP:0010771 10.15 IL6 INS LEP LEPR TNF ADIPOQ
13 nervous system MP:0003631 10.15 APOE EDN1 HCRT ICAM1 IGF1 IL6
14 liver/biliary system MP:0005370 10.13 NOS3 TNF ACE ADIPOQ APOE IL6
15 renal/urinary system MP:0005367 10.06 ACE ADIPOQ APOE EDN1 IGF1 IL6
16 neoplasm MP:0002006 10.01 TNF ACE ADIPOQ ICAM1 IGF1 IL6
17 reproductive system MP:0005389 9.96 ACE APOE IGF1 IL6 INS LEP
18 respiratory system MP:0005388 9.81 ADIPOQ APOE HCRT IGF1 IL6 LEP
19 skeleton MP:0005390 9.7 ADIPOQ APOE EDN1 HTR2A IGF1 IL6
20 vision/eye MP:0005391 9.23 APOE ICAM1 IL6 INS LEP LEPR

Drugs & Therapeutics for Sleep Apnea

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cafcit Injection 17 CAFFEINE CITRATE Roxane Laboratories September 1999

Drugs for Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 448)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 4 120014-06-4 3152
2
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
3
Dexlansoprazole Approved Phase 4 138530-94-6, 103577-45-3 9578005
4
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
5
Clonidine Approved Phase 4 4205-90-7 2803
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7
Nitric Oxide Approved Phase 4 10102-43-9 145068
8
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
9
Budesonide Approved Phase 4,Phase 3,Phase 1 51333-22-3 63006 5281004
10
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
11
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2 59-66-5 1986
12
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2 2216-51-5 16666
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 437-38-7 3345
14
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
15
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
16
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
17
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
18
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
19
Adalimumab Approved Phase 4 331731-18-1 16219006
20
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
21
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
22
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
23
Sodium oxybate Approved Phase 4 502-85-2 5360545
24
Zolpidem Approved Phase 4 82626-48-0 5732
25
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
26
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
27
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
28
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
30
Ephedrine Approved Phase 4 299-42-3 9294
31
Pseudoephedrine Approved Phase 4 90-82-4 7028
32
Xylometazoline Approved Phase 4 526-36-3 5709
33
Losartan Approved Phase 4,Phase 2 114798-26-4 3961
34
Eszopiclone Approved Phase 4,Phase 2,Early Phase 1 138729-47-2 969472
35
Norepinephrine Approved Phase 4 51-41-2 439260
36
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
37
Pantoprazole Approved Phase 4 102625-70-7 4679
38
Eplerenone Approved Phase 4 107724-20-9 150310 443872
39
Remifentanil Approved Phase 4,Early Phase 1 132875-61-7 60815
40
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
41
Phentermine Approved, Illicit Phase 4,Phase 1,Phase 2 122-09-8 4771
42
Topiramate Approved Phase 4,Phase 1,Phase 2 97240-79-4 5284627
43
Olanzapine Approved, Investigational Phase 4,Phase 1 132539-06-1 4585
44
Testosterone Approved, Investigational Phase 4 58-22-0 6013
45
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
46
Desflurane Approved Phase 4 57041-67-5 42113
47
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
48
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
49
Dopamine Approved Phase 4,Phase 1 51-61-6, 62-31-7 681
50
Trazodone Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 19794-93-5 5533

Interventional clinical trials:

(show top 50) (show all 1692)

id Name Status NCT ID Phase Drugs
1 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
2 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
3 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
4 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
5 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
6 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
7 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Unknown status NCT01699126 Phase 4 Statin
8 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
9 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
10 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
11 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
12 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
13 Treatment of Cheyne Stocks Respiration With Adaptive Servo Ventilation and Bilevel Ventilators in Patients With Chronic Heart Failure Unknown status NCT00725595 Phase 4
14 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
15 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
16 Resistant Hypertension Optimal Treatment Unknown status NCT01643434 Phase 4 Spironolactone;Clonidine
17 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
18 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
19 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
20 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4 Adalimumab;Placebo
21 Sleep Apnea and Oxidative Stress and Nitric Oxide Completed NCT00547937 Phase 4
22 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome Completed NCT01635010 Phase 4
23 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
24 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4 Paroxetine;5HTP
25 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
26 Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea Completed NCT02160223 Phase 4 Sugammadex;Neostigmine
27 Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients Completed NCT00741520 Phase 4
28 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed NCT02264353 Phase 4 Donepezil;placebo
29 Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea Completed NCT01945801 Phase 4 Lasilactone;Placebo
30 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients Completed NCT00708786 Phase 4
31 Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea Completed NCT00772044 Phase 4
32 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4 Dexmedetomidine;Propofol
33 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
34 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
35 Sleep Apnea. Concordance Between Non-reference and Reference Centres Completed NCT00424658 Phase 4
36 Nasal Decongestion and Obstructive Sleep Apnea Completed NCT00630474 Phase 4 xylometazoline
37 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
38 Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment Completed NCT00701428 Phase 4 Losartan
39 Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude Completed NCT00928655 Phase 4 acetazolamide;placebo
40 Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment Completed NCT00400543 Phase 4
41 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
42 Effect of Continuous Positive Airway Pressure (CPAP) on Hypertension and Cardiovascular Morbidity-Mortality in Patients With Sleep Apnea and no Daytime Sleepiness Completed NCT00127348 Phase 4
43 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
44 CPAP in Diabetes Type 2 Patients With Sleep Apnea Completed NCT01801150 Phase 4
45 Continuous Positive Airway Pressure (CPAP) Treatment in Coronary Artery Disease and Sleep Apnea Completed NCT00519597 Phase 4
46 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4 armodafinil;placebo
47 Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome Completed NCT01508754 Phase 4
48 Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients Completed NCT00729963 Phase 4 Sibutramine
49 Automate Detection of Sleep Apnea by ApneascanTM Completed NCT02045173 Phase 4
50 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4

Search NIH Clinical Center for Sleep Apnea

Genetic Tests for Sleep Apnea

Genetic tests related to Sleep Apnea:

id Genetic test Affiliating Genes
1 Sleep Apnea 29

Anatomical Context for Sleep Apnea

MalaCards organs/tissues related to Sleep Apnea:

39
Heart, Testes, Endothelial, Lung, Brain, Liver, Kidney

Publications for Sleep Apnea

Articles related to Sleep Apnea:

(show top 50) (show all 1669)
id Title Authors Year
1
Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome. ( 27754829 )
2017
2
Risk of obstructive sleep apnea among patients with Cushing's syndrome: a nationwide longitudinal study. ( 28735920 )
2017
3
The importance of calprotectin levels in the obstructive sleep apnea syndrome severity. ( 28933970 )
2017
4
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
5
Obstructive sleep apnea risk and leukocyte telomere length in African Americans from the MH-GRID study. ( 28083855 )
2017
6
Corrigendum to "Screening, diagnosis, and management of obstructive sleep apnea in dangerous-goods truck drivers: to be aware or not?" [Sleep Med. 2016;25:98-104]. ( 28057498 )
2017
7
Increased prevalence of obstructive sleep apnea in patients with Cushing's syndrome compared with weight- and age-matched controls. ( 27932409 )
2017
8
The Erlangen Questionnaire: a new 5-item screening tool for obstructive sleep apnea in a sleep clinic population - A prospective, double blinded study. ( 28925472 )
2017
9
Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea. ( 27321703 )
2017
10
Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. ( 28449901 )
2017
11
Corrigendum to "Prevalence and predictors of obstructive sleep apnea in young children with Down syndrome" [Sleep Med 27-28 (2016) 99-106]. ( 28457800 )
2017
12
Association between central sleep apnea and left ventricular structure: the Multi-Ethnic Study of Atherosclerosis. ( 28220556 )
2017
13
Sleep Complaints and Sleep Architecture in Children With Idiopathic Central Sleep Apnea. ( 28212689 )
2017
14
Determinants of obstructive sleep apnea syndrome: Pro-inflammatory state and dysfunction of high-density lipoprotein. ( 28935145 )
2017
15
Tracking Dynamic Tongue Motion in Ultrasound Images for Obstructive Sleep Apnea. ( 28942270 )
2017
16
A comparison of two screening tools for paediatric obstructive sleep apnea. ( 28944605 )
2017
17
Pacemaker-detected severe sleep apnea predicts new-onset atrial fibrillation. ( 28073884 )
2017
18
Obstructive Sleep Apnea and Pulmonary Hypertension in Children. ( 28185814 )
2017
19
Non-Mask-based Therapies for Central Sleep Apnea in Patients with Heart Failure. ( 28477779 )
2017
20
Sleep disturbance as a clinical sign for severe hypogonadism: efficacy of testosterone replacement therapy on sleep disturbance among hypogonadal men without obstructive sleep apnea. ( 28920756 )
2017
21
Is C-reactive protein a marker of obstructive sleep apnea?: A meta-analysis. ( 28489776 )
2017
22
The effect of early fusion of the spheno-occipital synchondrosis on midface hypoplasia and obstructive sleep apnea in patients with Crouzon syndrome. ( 28479031 )
2017
23
RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNEA AND THE PRESENCE AND SEVERITY OF DIABETIC RETINOPATHY. ( 28937527 )
2017
24
Diastolic Blood Pressure Rises with the Exacerbation of Obstructive Sleep Apnea in Males. ( 28922573 )
2017
25
Evaluation of the central sleep apnea in asymptomatic children with Chiari 1 malformation: an open question. ( 28382434 )
2017
26
Prevalence of obstructive sleep apnea syndrome in a population of patients with transient global amnesia. ( 28366339 )
2017
27
The Sleep Apnea Cardiovascular Endpoints (SAVE) study: implications for health services and sleep research in China and elsewhere. ( 28932508 )
2017
28
Effect of jaw-opening exercise on prevention of temporomandibular disorders pain associated with oral appliance therapy in obstructive sleep apnea patients: A randomized, double-blind, placebo-controlled trial. ( 28063976 )
2017
29
Predominant obstructive or central sleep apnea in patients with atrial fibrillation: influence of characterizing apneas versus apneas and hypopneas. ( 28899542 )
2017
30
Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds. ( 28931931 )
2017
31
Telemedicine: A Key Tool for Improving CPAP Adherence in Sleep Apnea Patients? ( 28926279 )
2017
32
Prevalence of acromegaly in patients with symptoms of sleep apnea. ( 28898247 )
2017
33
Central sleep apnea: the problem of diagnosis. ( 28153696 )
2017
34
Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. ( 28668820 )
2017
35
Epidemiological characteristics and gender-specific differences of obstructive sleep apnea in a Chinese hypertensive population: a cross-sectional study. ( 28056799 )
2017
36
Clinical Use of a Home Sleep Apnea Test: An American Academy of Sleep Medicine Position Statement. ( 28942762 )
2017
37
The association of nonalcoholic steatohepatitis and obstructive sleep apnea. ( 28914694 )
2017
38
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? ( 28168435 )
2017
39
C-reactive protein improves the ability to detect cardiometabolic risk in mild-to-moderate obstructive sleep apnea. ( 28947597 )
2017
40
REM sleep behavior disorder and obstructive sleep apnea: does one "evil" make the other less or more "evil"? ( 28754242 )
2017
41
Carotid Artery Wall Thickness in Obese and Nonobese Adults With Obstructive Sleep Apnea Before and Following Positive Airway Pressure Treatment. ( 28934533 )
2017
42
Correlation between Calpain-10 single-nucleotide polymorphisms and obstructive sleep apnea/hypopnoea syndrome with ischemic stroke in a Chinese population: A population-based study. ( 28422847 )
2017
43
Evaluation of Cerebrovascular Reactivity in Subjects with and without Obstructive Sleep Apnea. ( 28918088 )
2017
44
Surgical Treatment of Obstructive Sleep Apnea on Cardiovascular Outcomes: A Systematic Review. ( 28923761 )
2017
45
Corneal Neovascularization with Associated Lipid Keratopathy in a Patient with Obstructive Sleep Apnea-Hypopnea Syndrome Using a Continuous Positive Airway Pressure Machine. ( 28924439 )
2017
46
Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A case series. ( 28545360 )
2017
47
Maxillary Expansion and Mandibular Setback Surgery With and Without Mandibular Anterior Segment Osteotomy to Correct Mandibular Prognathism With Obstructive Sleep Apnea. ( 28060088 )
2017
48
Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes. ( 28931780 )
2017
49
In Patients with Vascular Disease, Treating Sleep Apnea Does Not Reduce the Risk of Cardiovascular Events. ( 28084709 )
2017
50
Gray Matter Hypertrophy and Thickening with Obstructive Sleep Apnea in Middle-aged and Older Adults. ( 28060546 )
2017

Variations for Sleep Apnea

ClinVar genetic disease variations for Sleep Apnea:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 AHDC1 NM_001029882.3(AHDC1): c.2373_2374delTG (p.Cys791Trpfs) deletion Pathogenic rs587779766 GRCh37 Chromosome 1, 27876253: 27876254
2 AHDC1 NM_001029882.3(AHDC1): c.2898delC (p.Tyr967Thrfs) deletion Pathogenic rs587779767 GRCh37 Chromosome 1, 27875729: 27875729
3 AHDC1 NM_001029882.3(AHDC1): c.2547delC (p.Ser850Profs) deletion Pathogenic rs587779768 GRCh37 Chromosome 1, 27876080: 27876080

Expression for Sleep Apnea

Search GEO for disease gene expression data for Sleep Apnea.

Pathways for Sleep Apnea

Pathways related to Sleep Apnea according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 APOE CXCL8 EDN1 GHRL HCRT HTR2A
2
Show member pathways
13.46 ADIPOQ APOE CXCL8 IL6 INS LEP
3
Show member pathways
12.76 ADIPOQ IL6 INS LEP TNF
4
Show member pathways
12.41 ADIPOQ IGF1 INS LEP LEPR
6 12.15 CXCL8 HTR2A IL6 TNF
7
Show member pathways
12.13 EDN1 IGF1 NPPB TNF
8
Show member pathways
12.11 ACE GHRL IGF1 INS LEP REN
9 12.06 EDN1 ICAM1 NOS3 TNF
10 11.96 CXCL8 ICAM1 IL6 TNF
11 11.95 CXCL8 ICAM1 IL6 LEP TNF
12
Show member pathways
11.92 IL6 INS NOS3 TNF
13 11.91 EDN1 ICAM1 IL6 TNF
14 11.89 CXCL8 IGF1 IL6 INS
15 11.85 EDN1 IGF1 IL6 INS NOS3
16 11.81 CXCL8 ICAM1 IL6 TNF
17 11.81 ADIPOQ IGF1 IL6 INS LEP
18 11.77 CXCL8 ICAM1 IL6
19 11.73 CXCL8 IL6 TNF
20 11.69 ADIPOQ LEP LEPR TNF
21 11.68 ICAM1 IL6 TNF
22
Show member pathways
11.64 CXCL8 ICAM1 IL6 TNF
23 11.57 CXCL8 IL6 INS
24 11.56 CXCL8 IL6 TNF
25 11.55 ADIPOQ IGF1 IL6 INS LEP TNF
26 11.52 INS LEP LEPR
27 11.52 CXCL8 ICAM1 IL6 TNF
28 11.5 CXCL8 ICAM1 IL6 TNF
29 11.49 ICAM1 IL6 TNF
30 11.49 IGF1 IL6 INS
31 11.45 APOE IGF1 IL6 TNF
32 11.45 CXCL8 EDN1 IGF1 IL6 TNF
33 11.33 ICAM1 IL6 TNF
34 11.31 CXCL8 IL6 NOS3
35
Show member pathways
11.18 CRP EDN1 LEP LEPR
36 11.1 CXCL8 EDN1 ICAM1 IL6 NOS3 TNF
37 10.97 ADIPOQ IL6 LEP TNF
38 10.74 CRP CXCL8 IL6 TNF

GO Terms for Sleep Apnea

Cellular components related to Sleep Apnea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ACE ADIPOQ APOE CRP CXCL8 EDN1
2 extracellular space GO:0005615 9.5 ACE ADIPOQ APOE CRP CXCL8 EDN1

Biological processes related to Sleep Apnea according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.96 EDN1 GHRL HCRT HTR2A
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 ICAM1 IL6 INS TNF
3 cellular response to lipopolysaccharide GO:0071222 9.95 CXCL8 ICAM1 IL6 TNF
4 cellular response to tumor necrosis factor GO:0071356 9.92 CXCL8 EDN1 ICAM1 IL6
5 response to insulin GO:0032868 9.9 ICAM1 IL6 LEP
6 response to glucocorticoid GO:0051384 9.9 ADIPOQ IL6 TNF
7 cellular response to drug GO:0035690 9.9 ADIPOQ EDN1 REN
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.89 IGF1 INS LEP
9 positive regulation of MAP kinase activity GO:0043406 9.88 EDN1 HTR2A TNF
10 positive regulation of protein kinase B signaling GO:0051897 9.88 IL6 INS LEP TNF
11 positive regulation of MAPK cascade GO:0043410 9.88 IGF1 IL6 INS LEP
12 response to drug GO:0042493 9.88 ADIPOQ EDN1 HTR2A ICAM1 IL6 REN
13 response to lipopolysaccharide GO:0032496 9.87 EDN1 ICAM1 IL6 REN
14 response to heat GO:0009408 9.85 IGF1 IL6 NOS3
15 negative regulation of fat cell differentiation GO:0045599 9.85 ADIPOQ IL6 TNF
16 response to activity GO:0014823 9.84 ADIPOQ EDN1 LEP
17 positive regulation of DNA replication GO:0045740 9.84 IGF1 IL6 INS
18 cellular response to interleukin-1 GO:0071347 9.84 CXCL8 EDN1 ICAM1 IL6
19 response to hypoxia GO:0001666 9.83 ADIPOQ EDN1 ICAM1 LEP
20 glucose homeostasis GO:0042593 9.83 ADIPOQ IL6 INS LEP LEPR
21 acute-phase response GO:0006953 9.82 CRP IL6 INS
22 negative regulation of endothelial cell proliferation GO:0001937 9.81 APOE GHRL TNF
23 response to amino acid GO:0043200 9.8 EDN1 ICAM1 IL6
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 EDN1 IGF1 IL6 TNF
25 phosphatidylinositol 3-kinase signaling GO:0014065 9.79 EDN1 HTR2A IGF1
26 positive regulation of glucose import GO:0046326 9.78 ADIPOQ IGF1 INS
27 positive regulation of mitotic nuclear division GO:0045840 9.77 EDN1 IGF1 INS
28 glucose metabolic process GO:0006006 9.77 ADIPOQ GHRL INS LEP TNF
29 negative regulation of glucose import GO:0046325 9.74 LEP TNF
30 response to dietary excess GO:0002021 9.74 APOE LEP
31 sexual reproduction GO:0019953 9.74 LEP LEPR
32 neutrophil mediated immunity GO:0002446 9.73 ACE IL6
33 response to leptin GO:0044321 9.73 EDN1 LEPR
34 adult feeding behavior GO:0008343 9.73 GHRL LEP
35 positive regulation of glycolytic process GO:0045821 9.73 HTR2A IGF1 INS
36 leptin-mediated signaling pathway GO:0033210 9.72 LEP LEPR
37 body fluid secretion GO:0007589 9.72 EDN1 NPPB
38 artery smooth muscle contraction GO:0014824 9.72 EDN1 HTR2A
39 negative regulation of platelet activation GO:0010544 9.72 APOE NOS3
40 regulation of blood vessel size GO:0050880 9.72 EDN1 NOS3 NPPB
41 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IGF1 IL6
42 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.71 EDN1 IGF1
43 ovulation from ovarian follicle GO:0001542 9.71 LEP NOS3
44 regulation of bone remodeling GO:0046850 9.7 LEP LEPR
45 negative regulation of hydrolase activity GO:0051346 9.7 LEPR NOS3
46 receptor-mediated virion attachment to host cell GO:0046813 9.69 ACE ICAM1
47 negative regulation of cellular protein metabolic process GO:0032269 9.69 APOE EDN1
48 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 ICAM1 TNF
49 response to nutrient levels GO:0031667 9.69