MCID: SLP005
MIFTS: 57

Sleep Disorder malady

Neuronal diseases category

Summaries for Sleep Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Is it hard for you to fall asleep or stay asleep through the night? do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? you might have a sleep disorder. the most common kinds are insomnia - a hard time falling or staying asleep sleep apnea - breathing interruptions during sleep restless legs syndrome - a tingling or prickly sensation in the legs narcolepsy - daytime "sleep attacks" nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. there are treatments for most sleep disorders. sometimes just having regular sleep habits can help.

MalaCards: Sleep Disorder, also known as non-organic sleep disorder, is related to obesity and myotonic dystrophy. An important gene associated with Sleep Disorder is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Orexin and neuropeptides FF and QRFP bind to their respective receptors and Metabolic States and Circadian Oscillators. The drugs zolpidem and zolpidem tartrate and the compounds s22153 and iik7 have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and heart, and related mouse phenotype behavior/neurological.

Disease Ontology:8 A disease of mental health that involves disruption of sleep patterns.

Wikipedia:63 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Aliases & Classifications for Sleep Disorder

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 33MedlinePlus, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Sleep Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.6HCRT, CYSLTR2, CLOCK, HRH3, PER2
2myotonic dystrophy30.3HCRT, GAA
3multiple system atrophy30.3TSPO
4advanced sleep phase syndrome30.1PER3, PER2
5migraine30.1HRH3, HCRT, NPS
6attention deficit hyperactivity disorder30.0HRH3
7delayed sleep phase syndrome30.0CLOCK, PER3, PER2
8dementia29.8HCRT, HRH3, TSPO
9narcolepsy10.5
10parkinson's disease10.3
11neuromuscular disease10.3
12diabetes mellitus10.3
13restless legs syndrome10.2
14prader-willi syndrome10.2
15bruxism10.2
16rem sleep behavior disorder10.2
17dyspepsia10.2
18periodic limb movement disorder10.2
19systolic heart failure10.2
20chronic fatigue syndrome10.2
21multiple sclerosis10.2
22tuberous sclerosis10.2
23achondroplasia10.2
24type 2 diabetes mellitus10.2
25kleine-levin syndrome10.1
26myotonic dystrophy type 210.1
27anxiety disorder10.1
28intellectual disability10.1
29respiratory failure10.1
30myotonic dystrophy type 110.1
31non 24 hour sleep wake disorder10.1
32sleep apnea10.1
33insomnia10.1
34narcolepsy 110.1
35proliferative diabetic retinopathy10.0
36rett syndrome10.0
37machado-joseph disease10.0
38major depressive disorder10.0
39angelman syndrome10.0
40brugada syndrome10.0
41bronchiectasis10.0
42diabetic macular edema10.0
43central sleep apnea10.0
44cleft lip10.0
45neuronitis10.0
46acromegaly10.0
47glucose intolerance10.0
48cleft palate10.0
49diastolic heart failure10.0
50down syndrome10.0

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to sleep disorder

Clinical Features for Sleep Disorder

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Drugs & Therapeutics for Sleep Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sleep Disorder

Drug clinical trials:

Search ClinicalTrials for Sleep Disorder

Search NIH Clinical Center for Sleep Disorder

Search CenterWatch for Sleep Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sleep Disorder

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Anatomical Context for Sleep Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Sleep Disorder:

32
Testes, Eye, Heart, Brain, Lung, Pituitary, Tonsil, Monocytes, Thyroid, Whole blood, Kidney, Spinal cord, Skin, Hypothalamus

Animal Models for Sleep Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Sleep Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.8PER1, GAA, MTNR1A, NR1D1, HCRT, HCRTR1

Publications for Sleep Disorder

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Sources:
50PubMed
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Articles related to Sleep Disorder:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
Use of the Sleep Apnea Scale of the Sleep Disorders Questionnaire (SA-SDQ) in adults with epilepsy. (24397915)
2014
2
Intrusion of rapid eye movement (REM) behavior disorder episodes into NREM sleep in a case of Lewy body dementia. (23063303)
2013
3
Prevalence and clinical characteristics of unremembered nocturnal eating in diabetic subjects: Kurume sleep trouble in obesity and metabolic disorders (KUSTOMED) study. (23774071)
2013
4
Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling. (22776420)
2013
5
A case of REM sleep behavior disorder, narcolepsy-cataplexy, parkinsonism and rheumatoid arthritis. (23619083)
2013
6
Mood and metabolic consequences of sleep deprivation as a potential endophenotype' in bipolar disorder. (23664567)
2013
7
Effect of contingent electrical stimulation on masticatory muscle activity and pain in patients with a myofascial temporomandibular disorder and sleep bruxism. (23424717)
2013
8
Melatonin profile and its relation to circadian rhythm sleep disorders in Angelman syndrome patients. (22841843)
2012
9
Effect of imidafenacin on nocturia and sleep disorder in patients with overactive bladder. (22832092)
2012
10
Validation of the Innsbruck REM sleep behavior disorder inventory. (23192924)
2012
11
Sleep disordered breathing, insomnia symptoms, and sleep quality in a clinical cohort of U.S. Hispanics in south Florida. (23066361)
2012
12
Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. (21211848)
2011
13
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. (21317035)
2011
14
Delayed sleep phase syndrome is related to seasonal affective disorder. (21601293)
2011
15
Sleep disorders in spinocerebellar ataxia type 2 patients. (21494015)
2011
16
Sleep disorder in Taiwanese nurses: a random sample survey. (22011090)
2011
17
Diagnosing narcolepsy with cataplexy on history alone: challenging the International Classification of Sleep Disorders (ICSD-2) criteria. (21658163)
2011
18
Do evoked potential differences reflect a deficit in those suffering a sleep disorder, or resilience in those who can avoid it? (20469799)
2010
19
Prevalence of laryngomalacia in children presenting with sleep-disordered breathing. (20568277)
2010
20
Olfactory dysfunction in idiopathic REM sleep behavior disorder. (20378403)
2010
21
Does effective management of sleep disorders reduce substance dependence? (20047351)
2009
22
Otorhinolaryngologic examination in obstructive sleep apnea syndrome: the correlation between the severity of sleep disorder and physical examination. (19961403)
2009
23
REM sleep behavior disorder and the risk of developing Parkinson disease or dementia. (19164135)
2009
24
Excessive muscle activity increases over time in idiopathic REM sleep behavior disorder. (19750919)
2009
25
Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. (19109537)
2009
26
Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. (18853938)
2008
27
A quantitative statistical analysis of the submentalis muscle EMG amplitude during sleep in normal controls and patients with REM sleep behavior disorder. (18275559)
2008
28
Disorders of pulmonary function, sleep, and the upper airway in Charcot-Marie-Tooth disease. (17294338)
2007
29
Psychomotor development in infants with Prader-Willi syndrome and associations with sleep-related breathing disorders. (17597659)
2007
30
REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (17239112)
2006
31
Potential impact of sleep disorder treatment in fibromyalgia patients. (16801519)
2006
32
Symptom burden of sleep-disordered breathing in systolic heart failure patients. (16880377)
2006
33
Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder. (15961535)
2005
34
Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? (14718695)
2004
35
A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders. (15187983)
2004
36
REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. (15312278)
2004
37
Obstructive sleep apnoea syndrome--an oxidative stress disorder. (12586529)
2003
38
Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. (14581700)
2003
39
Law of denervation and spinal mechanism of leg movements in sleep. Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism. (11438257)
2001
40
Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole. (12404588)
2001
41
An animal model for pregnancy-associated sleep disorder. (9628156)
1998
42
The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression. (9629951)
1998
43
A 50-year-old male with diabetes mellitus, peripheral neuropathy, hypothyroidism, obesity, sleep disorder, pickwickian syndrome, and heart failure. (9844373)
1998
44
Sleep bruxism as a manifestation of subclinical rapid eye movement sleep behavior disorder. (7809570)
1994
45
The treatment of sleep disorders. (1585214)
1992
46
Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder. (1621023)
1992
47
Polysomnography and sleep disorder centers. (1822678)
1991
48
Hospital sleep disorder programs open doors to sleepy patients. (10111106)
1990
49
REM sleep behavior disorder. (3358475)
1988
50
Marketing of a sleep disorder lab ... and attracting a backlog of snorers. (10277776)
1986

Genetic Variations for Sleep Disorder

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Expression for genes affiliated with Sleep Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for genes affiliated with Sleep Disorder

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Sleep Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4HCRTR1, HCRT
210.4CLOCK, PER1
310.3CLOCK, PER2, PER1
4
Hide members
10.3PER1, PER2, PER3, CLOCK
5
Hide members
10.3CYSLTR1, CYSLTR2, MTNR1A, MTNR1B
610.3CYSLTR1, CYSLTR2, HCRTR1, HCRT
710.2CSNK1E, NR1D1, CLOCK, PER1
8
Hide members
10.2CYSLTR1, CYSLTR2, HCRTR1, HCRT, NPS
9
Hide members
10.2MTNR1B, MTNR1A, CLOCK, PER3, PER2, PER1
10
Hide members
10.1PER1, CSNK1E, NR1D1, CLOCK, PER3, PER2
11
Hide members
10.0NPS, MTNR1B, MTNR1A, HCRT, HCRTR1, CYSLTR2
12
Hide members
10.0NPS, MTNR1B, MTNR1A, HCRT, HCRTR1, CYSLTR2

Compounds for genes affiliated with Sleep Disorder

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Sleep Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1s221532810.8MTNR1A, MTNR1B
2iik72810.8MTNR1B, MTNR1A
36-cl-mlt2810.8MTNR1B, MTNR1A
4s262842810.8MTNR1B, MTNR1A
5s261312810.8MTNR1B, MTNR1A
6gr 1964292810.8MTNR1B, MTNR1A
7[3h]melatonin2810.8MTNR1B, MTNR1A
85-heat2810.8MTNR1A, MTNR1B
9s209282810.8MTNR1B, MTNR1A
10gr 1281072810.8MTNR1B, MTNR1A
11s247732810.8MTNR1B, MTNR1A
124p-pdot2810.8MTNR1B, MTNR1A
13k1852810.8MTNR1B, MTNR1A
14s240142810.8MTNR1B, MTNR1A
15ly 1567352810.8MTNR1B, MTNR1A
16ramelteon44 28 1112.8MTNR1B, MTNR1A, TSPO
17bayu97732810.8CYSLTR2, CYSLTR1
18baycyslt22810.8CYSLTR2, CYSLTR1
19lte42810.8CYSLTR2, CYSLTR1
20iralukast2810.8CYSLTR2, CYSLTR1
21luzindole59 2811.7MTNR1A, MTNR1B
22[3h]ici-1986152810.7CYSLTR2, CYSLTR1
232-[125i]mlt2810.7MTNR1B, MTNR1A
24[3h]ltd42810.7CYSLTR2, CYSLTR1
252-iodo-melatonin2810.7MTNR1B, MTNR1A
26n-methyl ltc42810.7CYSLTR1, CYSLTR2
272-iodomelatonin5910.7MTNR1B, MTNR1A
28prazosin hydrochloride5910.7MTNR1B, MTNR1A
294-p-pdot5910.7MTNR1B, MTNR1A
30ltd42810.7CYSLTR2, CYSLTR1
31ltc42810.7CYSLTR2, CYSLTR1
32pobilukast44 2811.7CYSLTR2, CYSLTR1
33isoflurane44 1111.7HCRT, HCRTR1, TSPO
34ly 25528359 4411.7CYSLTR2, CYSLTR1
35cinalukast59 1111.6CYSLTR2, CYSLTR1
36melatonin44 59 28 11 2414.6PER1, PER2, CLOCK, HCRT, MTNR1A, MTNR1B
3717-odya5910.6CYSLTR2, CYSLTR1
38nedocromil49 1111.6CYSLTR2, CYSLTR1
39agomelatine28 44 1112.6MTNR1A, MTNR1B
40octadecaneuropeptide4410.6HCRT, TSPO
41histamine44 28 2412.5TSPO, HRH3, CYSLTR1, CYSLTR2, HCRT
42lte44410.5CYSLTR1, CYSLTR2
435-oxoete4410.5CYSLTR1, CYSLTR2
44zafirlukast44 28 1112.5CYSLTR1, CYSLTR2
45dopamine44 28 11 2413.4TSPO, HRH3, CLOCK, HCRTR1, HCRT
46gamma-hydroxybutyrate4410.4TSPO, HCRT
47ltd44410.4CYSLTR1, CYSLTR2
48acetylcholine44 49 28 11 2414.3HCRT, HCRTR1, HRH3, TSPO
49pranlukast44 28 1112.3CYSLTR2, CYSLTR1
50mk 57144 5911.1CYSLTR1, CYSLTR2

GO Terms for genes affiliated with Sleep Disorder

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16Gene Ontology
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Cellular components related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.1FXYD1, HRH3, CYSLTR1, HCRTR1, MTNR1A, MTNR1B

Biological processes related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcium ion transportGO:05192810.4TSPO, HCRT
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3MTNR1B, MTNR1A, HRH3
3circadian rhythmGO:00762310.2PER1, PER2, PER3, CLOCK, NR1D1, MTNR1A
4neuropeptide signaling pathwayGO:00721810.2HCRTR1, HCRT, NPS
5circadian regulation of gene expressionGO:03292210.1PER1, CLOCK

Molecular functions related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein binding transcription factor activityGO:00098810.4PER1, PER2
2melatonin receptor activityGO:00850210.4MTNR1A, MTNR1B
3leukotriene receptor activityGO:00497410.3CYSLTR1, CYSLTR2
4signal transducer activityGO:00487110.0CLOCK, PER3, PER2, PER1

Products for genes affiliated with Sleep Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleep Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet