MCID: SLP005
MIFTS: 54

Sleep Disorder malady

Neuronal category

Summaries for Sleep Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Is it hard for you to fall asleep or stay asleep through the night? do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? you might have a sleep disorder. the most common kinds are insomnia - a hard time falling or staying asleep sleep apnea - breathing interruptions during sleep restless legs syndrome - a tingling or prickly sensation in the legs narcolepsy - daytime "sleep attacks" nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. there are treatments for most sleep disorders. sometimes just having regular sleep habits can help.

MalaCards: Sleep Disorder, also known as non-organic sleep disorder, is related to advanced sleep phase syndrome and attention deficit hyperactivity disorder. An important gene associated with Sleep Disorder is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Orexin and neuropeptides FF and QRFP bind to their respective receptors and Metabolic States and Circadian Oscillators. The drugs zolpidem and zolpidem tartrate and the compounds s22153 and iik7 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and spinal cord, and related mouse phenotype behavior/neurological.

Disease Ontology:8 A disease of mental health that involves disruption of sleep patterns.

Wikipedia:64 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Aliases & Classifications for Sleep Disorder

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 34MedlinePlus, 27ICD9CM, 35MeSH, 25ICD10
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Related Diseases for Sleep Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to sleep disorder

Clinical Features for Sleep Disorder

Drugs & Therapeutics for Sleep Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sleep Disorder

Drug clinical trials:

Search ClinicalTrials for Sleep Disorder

Search NIH Clinical Center for Sleep Disorder

Search CenterWatch for Sleep Disorder

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Sleep Disorder

Anatomical Context for Sleep Disorder

Sources:
33MalaCards
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MalaCards organs/tissues related to Sleep Disorder:

33
Whole blood, Brain, Spinal cord, Heart, Kidney, Lung, Thyroid, Adrenal gland, Skin, Tonsil, Monocytes, Fetal brain, Occipital lobe, Hypothalamus, Fetal lung, Fetal thyroid, Pituitary

Animal Models for Sleep Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Sleep Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.8PER1, GAA, MTNR1A, NR1D1, HCRT, HCRTR1

Publications for Sleep Disorder

Sources:
51PubMed
See all sources

Articles related to Sleep Disorder:

(show top 50)    (show all 927)
idTitleAuthorsYear
1
Prodromal Parkinson's disease--using REM sleep behavior disorder as a window. (24262156)
2014
2
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis. (24321163)
2013
3
Migraine and periodic limb movement disorders in sleep in children: a preliminary case-control study. (23815623)
2013
4
Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock. (23546644)
2013
5
REM sleep behavior disorder in Parkinson's disease: a questionnaire-based survey. (23319905)
2013
6
Altered overnight modulation of spontaneous waking EEG reflects altered sleep homeostasis in major depressive disorder: a high-density EEG investigation. (23810359)
2013
7
The Glasgow Sleep Impact Index (GSII): a novel patient-centred measure for assessing sleep-related quality of life impairment in Insomnia Disorder. (23347908)
2013
8
Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders. (23890955)
2013
9
The prevalence and associated risk factors of sleep disorder-related symptoms in pregnant women in China. (23132352)
2013
10
Sleep-related eating disorder: a descriptive study in Chilean patients. (24424097)
2013
11
Circadian sleep-wake cycles, well-being, and light therapy in borderline personality disorder. (22928852)
2013
12
Challenging behaviour and sleep cycle disorder following brain injury: A preliminary response to agomelatine treatment. (24378071)
2013
13
Sensorimotor gating deficits in multiple system atrophy: Comparison with Parkinson's disease and idiopathic REM sleep behavior disorder. (24355363)
2013
14
Plasma urate in REM sleep behavior disorder. (23536471)
2013
15
The spectrum of sleep-disordered breathing symptoms and respiratory events in infants with cleft lip and/or palate. (23042804)
2012
16
Enuresis associated with sleep disordered breathing in children with sickle cell anemia. (22910247)
2012
17
REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. (22328094)
2012
18
Hiding in plain sight: risk factors for REM sleep behavior disorder. (22744669)
2012
19
Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. (22539566)
2012
20
Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). (21337530)
2011
21
Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder. (21714973)
2011
22
The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder. (21115377)
2011
23
Sleep-disordered breathing in patients with the Brugada syndrome. (21247540)
2011
24
Reduced volume of the putamen in REM sleep behavior disorder patients. (20846895)
2010
25
Relevance of substantia nigra hyperechogenicity and reduced odor identification in idiopathic REM sleep behavior disorder. (20223708)
2010
26
Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus. (19913847)
2010
27
The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. (18359665)
2009
28
Periodic limb movements in sleep and periodic limb movement disorder. (17235435)
2007
29
Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes. (17299246)
2007
30
Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. (17157062)
2007
31
New perspectives for the treatment of disorders of sleep and arousal. (17652996)
2007
32
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
33
Sleep architecture in homicidal women with antisocial personality disorder--a preliminary study. (17070601)
2006
34
REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease. (17068986)
2006
35
Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. (15455441)
2004
36
Sleepwalking violence: a sleep disorder, a legal dilemma, and a psychological challenge. (15229043)
2004
37
Mayo study links heart rhythm problem to sleep disorder. (14619782)
2003
38
Article reviewed: Sleep-disordered breathing and respiratory failure in acid maltase deficiency. (14592241)
2002
39
Exacerbation of REM sleep behavior disorder by chocolate ingestion: a case report. (14592201)
2002
40
The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. (11113232)
2000
41
EEG and subjective sleepiness during extended wakefulness in seasonal affective disorder: circadian and homeostatic influences. (10745053)
2000
42
Microglia activation in a model of sleep disorder: an immunohistochemical study in the rat brain during Trypanosoma brucei infection. (10375652)
1999
43
Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Report. Standards of Practice Committee of the American Academy of Sleep Medicine. (10566915)
1999
44
Sleep bruxism is a disorder related to periodic arousals during sleep. (9539459)
1998
45
Apology. REM sleep behavior disorder: clinical and physiopathological findings. (15310507)
1998
46
Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. (9710029)
1998
47
Time-trend of sleep disorder in relation to night work: a study of sequential 1-year prevalences within the GAZEL cohort. (8826993)
1996
48
Lewy body disease in a patient with REM sleep disorder. (8628517)
1996
49
ABC of sleep disorder. Dreams and medical illness. (8490484)
1993
50
Effect of gradual withdrawal on the rebound sleep disorder after discontinuation of triazolam. (3306380)
1987

Genetic Variations for Sleep Disorder

Expression for genes affiliated with Sleep Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for genes affiliated with Sleep Disorder

Sources:
54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Sleep Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4HCRTR1, HCRT
210.4PER1, CLOCK
310.3PER2, PER1, CLOCK
4
Hide members
10.3PER2, PER1, PER3, CLOCK
5
Hide members
10.3CYSLTR1, CYSLTR2, MTNR1A, MTNR1B
610.3HCRT, HCRTR1, CYSLTR2, CYSLTR1
710.2NR1D1, CSNK1E, PER1, CLOCK
8
Hide members
10.2CYSLTR1, CYSLTR2, HCRT, NPS, HCRTR1
9
Hide members
10.2MTNR1B, MTNR1A, CLOCK, PER3, PER2, PER1
10
Hide members
10.1PER1, PER2, PER3, CLOCK, NR1D1, CSNK1E
11
Hide members
10.0MTNR1B, NPS, HRH3, MTNR1A, HCRT, HCRTR1
12
Hide members
10.0NPS, TSPO, MTNR1B, CYSLTR1, CYSLTR2, HCRTR1

Compounds for genes affiliated with Sleep Disorder

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB, 50PharmGKB
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Compounds related to Sleep Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1s221532910.8MTNR1A, MTNR1B
2iik72910.8MTNR1B, MTNR1A
36-cl-mlt2910.8MTNR1B, MTNR1A
4s262842910.8MTNR1B, MTNR1A
5s261312910.8MTNR1B, MTNR1A
6gr 1964292910.8MTNR1B, MTNR1A
7[3h]melatonin2910.8MTNR1B, MTNR1A
85-heat2910.8MTNR1A, MTNR1B
9s209282910.8MTNR1B, MTNR1A
10gr 1281072910.8MTNR1B, MTNR1A
11s247732910.8MTNR1B, MTNR1A
124p-pdot2910.8MTNR1B, MTNR1A
13k1852910.8MTNR1B, MTNR1A
14s240142910.8MTNR1B, MTNR1A
15ly 1567352910.8MTNR1B, MTNR1A
16ramelteon45 29 1112.8MTNR1B, MTNR1A, TSPO
17bayu97732910.8CYSLTR2, CYSLTR1
18baycyslt22910.8CYSLTR2, CYSLTR1
19lte42910.8CYSLTR2, CYSLTR1
20iralukast2910.8CYSLTR2, CYSLTR1
21luzindole60 2911.7MTNR1A, MTNR1B
22[3h]ici-1986152910.7CYSLTR2, CYSLTR1
232-[125i]mlt2910.7MTNR1B, MTNR1A
24[3h]ltd42910.7CYSLTR2, CYSLTR1
252-iodo-melatonin2910.7MTNR1B, MTNR1A
26n-methyl ltc42910.7CYSLTR1, CYSLTR2
272-iodomelatonin6010.7MTNR1B, MTNR1A
28prazosin hydrochloride6010.7MTNR1B, MTNR1A
294-p-pdot6010.7MTNR1B, MTNR1A
30ltd42910.7CYSLTR2, CYSLTR1
31ltc42910.7CYSLTR2, CYSLTR1
32pobilukast45 2911.7CYSLTR2, CYSLTR1
33isoflurane45 1111.7HCRT, HCRTR1, TSPO
34ly 25528360 4511.7CYSLTR2, CYSLTR1
35cinalukast60 1111.6CYSLTR2, CYSLTR1
36melatonin45 60 29 11 2414.6PER1, PER2, CLOCK, HCRT, MTNR1A, MTNR1B
3717-odya6010.6CYSLTR2, CYSLTR1
38nedocromil50 1111.6CYSLTR2, CYSLTR1
39agomelatine29 45 1112.6MTNR1A, MTNR1B
40octadecaneuropeptide4510.6HCRT, TSPO
41histamine45 29 2412.5TSPO, HRH3, CYSLTR1, CYSLTR2, HCRT
42lte44510.5CYSLTR1, CYSLTR2
435-oxoete4510.5CYSLTR1, CYSLTR2
44zafirlukast45 29 1112.5CYSLTR1, CYSLTR2
45dopamine45 29 11 2413.4TSPO, HRH3, CLOCK, HCRTR1, HCRT
46gamma-hydroxybutyrate4510.4TSPO, HCRT
47ltd44510.4CYSLTR1, CYSLTR2
48acetylcholine45 50 29 11 2414.3HCRT, HCRTR1, HRH3, TSPO
49pranlukast45 29 1112.3CYSLTR2, CYSLTR1
50mk 57145 6011.1CYSLTR1, CYSLTR2

GO Terms for genes affiliated with Sleep Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.1FXYD1, HRH3, CYSLTR1, HCRTR1, MTNR1A, MTNR1B

Biological processes related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcium ion transportGO:05192810.4TSPO, HCRT
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.3MTNR1B, MTNR1A, HRH3
3circadian rhythmGO:00762310.2PER1, PER2, PER3, CLOCK, NR1D1, MTNR1A
4neuropeptide signaling pathwayGO:00721810.2HCRTR1, HCRT, NPS
5circadian regulation of gene expressionGO:03292210.1PER1, CLOCK

Molecular functions related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein binding transcription factor activityGO:00098810.4PER1, PER2
2melatonin receptor activityGO:00850210.4MTNR1A, MTNR1B
3leukotriene receptor activityGO:00497410.3CYSLTR1, CYSLTR2
4signal transducer activityGO:00487110.0CLOCK, PER3, PER2, PER1

Products for genes affiliated with Sleep Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleep Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet