MCID: SLP005
MIFTS: 54

Sleep Disorder malady

Mental diseases, Neuronal diseases categories
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Summaries for Sleep Disorder

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Is it hard for you to fall asleep or stay asleep through the night? do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? you might have a sleep disorder. the most common kinds are insomnia - a hard time falling or staying asleep sleep apnea - breathing interruptions during sleep restless legs syndrome - a tingling or prickly sensation in the legs narcolepsy - daytime "sleep attacks" nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. there are treatments for most sleep disorders. sometimes just having regular sleep habits can help.

MalaCards: Sleep Disorder, also known as non-organic sleep disorder, is related to narcolepsy and obesity. An important gene associated with Sleep Disorder is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and Eicosanoid ligand-binding receptors. The drugs zolpidem and zolpidem tartrate and the compounds isoflurane and s24014 have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and brain, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A disease of mental health that involves disruption of sleep patterns.

Wikipedia:65 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Aliases & Classifications for Sleep Disorder

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8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 35MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Sleep Disorder

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to sleep disorder

Symptoms for Sleep Disorder

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Drugs & Therapeutics for Sleep Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Sleep Disorder

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Sleep Disorder

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Anatomical Context for Sleep Disorder

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33MalaCards
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MalaCards organs/tissues related to Sleep Disorder:

33
Testes, Heart, Brain, Lung, Eye, Tonsil, Skin, Kidney, Spinal cord, Whole blood, Hypothalamus

Animal Models for Sleep Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sleep Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8HCRT, HCRTR1, AANAT, HRH3, PER2
2MP:00053867.6HRH3, MTNR1A, HCRTR1, HCRT, PER2

Publications for Sleep Disorder

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52PubMed
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Articles related to Sleep Disorder:

(show top 50)    (show all 382)
idTitleAuthorsYear
1
Sleep disorders and the interpersonal-psychological theory of suicide: independent pathways to suicidality? (24182416)
2014
2
Use of the Sleep Apnea Scale of the Sleep Disorders Questionnaire (SA-SDQ) in adults with epilepsy. (24397915)
2014
3
A two-year prospective study on the frequency and co-occurrence of insomnia and sleep-disordered breathing symptoms in a primary care population. (23777754)
2013
4
Prevalence and clinical correlates of sleep disordered breathing in myotonic dystrophy types 1 and 2. (24310756)
2013
5
Prader-Willi syndrome and sleep-disordered breathing. (24126982)
2013
6
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis. (24321163)
2013
7
Prevalence and symptoms of occult sleep disordered breathing among older veterans with insomnia. (24235899)
2013
8
Respiratory and sleep disorders in female children with atypical Rett syndrome caused by mutations in the CDKL5 gene. (23151060)
2013
9
Correlation between sleep disorder screening and executive dysfunction in children with attention deficit-hyperactivity disorder. (24394878)
2013
10
Cardiac workload in patients with sleep-disordered breathing early after acute myocardial infarction. (23715560)
2013
11
Sleep disorders in children with Down syndrome. (23594294)
2013
12
Central sleep-disordered breathing and the effects of oxygen therapy in infants with Prader-Willi syndrome. (23761691)
2013
13
Increased prevalence of sleep-disordered breathing in Friedreich ataxia. (23700333)
2013
14
Fibromyalgia: gender differences and sleep-disordered breathing. (24373368)
2013
15
Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. (23917208)
2013
16
Sleep disordered breathing and other sleep dysfunction in myotonic dystrophy type 2. (22959494)
2012
17
Increased cysteinyl leukotriene concentration and receptor expression in tonsillar tissues of Chinese children with sleep-disordered breathing. (22634478)
2012
18
Narcolepsy and sleep-disordered breathing. (22182320)
2012
19
Effect of cognitive behavior therapy on sleep disorder in Parkinson's disease in China: a pilot study. (23186520)
2012
20
Free-running (non-entrained to 24-h period) circadian sleep disorder in a patient with obstructive sleep apnea, delayed sleep phase tendency, and lack of social interaction. (21594679)
2012
21
Stress and sleep disorder. (23319874)
2012
22
Legal issues encountered when treating the patient with a sleep disorder. (21208882)
2011
23
Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). (21337530)
2011
24
Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. (21211848)
2011
25
Cross-sectional study on relationship between constipation and medication in consideration of sleep disorder. (21804327)
2011
26
Obstructive sleep apnea: not just a sleep disorder. (21654148)
2011
27
Role of intranasal topical steroid in pediatric sleep disordered breathing and influence of allergy, sinusitis, and obesity on treatment outcome. (21461060)
2011
28
REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. (20022299)
2010
29
Shift work sleep disorder is associated with an attenuated brain response of sensory memory and an increased brain response to novelty: an ERP study. (20469813)
2010
30
Diagnostic pitfalls in children with sleep disorders: two cases with hypersomnia. (18754824)
2008
31
A diagnostic symptom profile for sleep disorder in primary care patients. (18374743)
2008
32
Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy. (17485650)
2007
33
Daytime hypoxemia, sleep-disordered breathing, and laryngopharyngeal findings in multiple system atrophy. (17562934)
2007
34
Survey of the present status of sleep-disordered breathing in children with achondroplasia Part I. A questionnaire survey. (15763281)
2005
35
Management of shift work sleep disorder: Alice in Wonderland redux? (15602174)
2004
36
Sleep, sleep disorders and hypocretin (orexin). (15301991)
2004
37
Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. (14646802)
2003
38
Mayo study links heart rhythm problem to sleep disorder. (14619782)
2003
39
Article reviewed: REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (14592242)
2002
40
REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (11412865)
2001
41
Methylphenidate and melatonin for sleep disorder with optic glioma. (11556641)
2001
42
Law of denervation and spinal mechanism of leg movements in sleep. Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism. (11438257)
2001
43
Sleep disorder, depression, and suicidality in female sexual assault survivors. (11419527)
2000
44
Microglia activation in a model of sleep disorder: an immunohistochemical study in the rat brain during Trypanosoma brucei infection. (10375652)
1999
45
Genetic factors in human sleep disorders with special reference to Norrie disease, Prader-Willi syndrome and Moebius syndrome. (10389102)
1999
46
Sleep disorders and anxiety: biochemical antecedents and pharmacological consequences. (7799254)
1994
47
Sleep disorder centers: how to plan a successful program. (1985846)
1991
48
Factitial leg ulcers associated with an unusual sleep disorder. (2310213)
1990
49
The place of sleep disorder centers in the evaluation and treatment of chronic insomniacs. (6242984)
1981
50
Sleep disorder and psychosis. (5937820)
1966

Variations for Sleep Disorder

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Expression for genes affiliated with Sleep Disorder

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for genes affiliated with Sleep Disorder

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Sources:
50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 55Reactome, 30KEGG
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Compounds for genes affiliated with Sleep Disorder

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Sources:
51PharmGKB, 45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Sleep Disorder according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1isoflurane51 45 1111.9HCRTR1, HCRT
2s24014299.8MTNR1A, MTNR1B
35-heat299.8MTNR1B, MTNR1A
4s22153299.8MTNR1B, MTNR1A
5iik7299.8MTNR1B, MTNR1A
66-cl-mlt299.8MTNR1B, MTNR1A
7k185299.8MTNR1A, MTNR1B
8s20928299.8MTNR1B, MTNR1A
9gr 128107299.8MTNR1B, MTNR1A
10s24773299.8MTNR1B, MTNR1A
114p-pdot299.8MTNR1B, MTNR1A
12s26284299.8MTNR1B, MTNR1A
132-iodo-melatonin299.8MTNR1A, MTNR1B
142-iodomelatonin619.8MTNR1B, MTNR1A
15prazosin hydrochloride619.8MTNR1B, MTNR1A
164-p-pdot619.8MTNR1B, MTNR1A
17luzindole61 2910.8MTNR1B, MTNR1A
182-[125i]mlt299.8MTNR1A, MTNR1B
19s26131299.8MTNR1B, MTNR1A
20gr 196429299.7MTNR1B, MTNR1A
21[3h]melatonin299.7MTNR1B, MTNR1A
22ly 156735299.7MTNR1B, MTNR1A
23ramelteon29 45 1111.7MTNR1B, MTNR1A
24agomelatine45 29 1111.7MTNR1B, MTNR1A
25thapsigargin45 6110.7HCRTR1, HCRT
266-hydroxymelatonin29 45 2411.7MTNR1A, MTNR1B
27phosphoserine45 2410.6CSNK1A1L, AANAT
285-hydroxytryptamine459.6AANAT, HCRT
29amine459.1AANAT, HRH3
30acetylcholine45 51 29 24 1113.0HRH3, HCRTR1, HCRT
31nicotine45 29 51 1112.0HRH3, HCRT
32alanine459.0HCRT, HCRTR1, AANAT
33glutamate458.9HRH3, CSNK1A1L, HCRT
34norepinephrine45 24 1110.9HCRT, AANAT, HRH3
35dopamine45 29 24 1111.5HRH3, AANAT, HCRTR1, HCRT
36melatonin45 29 61 24 1112.5AANAT, MTNR1A, MTNR1B, HCRT, PER2

GO Terms for genes affiliated with Sleep Disorder

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16Gene Ontology
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Cellular components related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.1AANAT, HCRT, PER2
2integral component of plasma membraneGO:0058877.9HRH3, MTNR1A, MTNR1B, HCRTR1

Biological processes related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide signaling pathwayGO:0072189.4HCRTR1, HCRT
2eating behaviorGO:0427559.3HCRT, HRH3
3positive regulation of cytosolic calcium ion concentrationGO:0072049.3HRH3, HCRT
4synaptic transmissionGO:0072689.1MTNR1B, HCRTR1, HCRT
5circadian rhythmGO:0076239.0AANAT, MTNR1A, PER2
6G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071878.7HRH3, MTNR1A, MTNR1B

Molecular functions related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melatonin receptor activityGO:0085029.4MTNR1A, MTNR1B

Products for genes affiliated with Sleep Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleep Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet