MCID: SLP005
MIFTS: 55

Sleep Disorder malady

Mental diseases, Neuronal diseases categories
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Summaries for Sleep Disorder

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MedlinePlus:33 Is it hard for you to fall asleep or stay asleep through the night? do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? you might have a sleep disorder. the most common kinds are insomnia - a hard time falling or staying asleep sleep apnea - breathing interruptions during sleep restless legs syndrome - a tingling or prickly sensation in the legs narcolepsy - daytime "sleep attacks" nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. there are treatments for most sleep disorders. sometimes just having regular sleep habits can help.

MalaCards based summary: Sleep Disorder, also known as non-organic sleep disorder, is related to narcolepsy and delayed sleep phase syndrome. An important gene associated with Sleep Disorder is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and Eicosanoid ligand-binding receptors. The drugs zolpidem and zolpidem tartrate and the compounds isoflurane and s24014 have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and brain, and related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology:8 A disease of mental health that involves disruption of sleep patterns.

Wikipedia:65 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Aliases & Classifications for Sleep Disorder

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Sleep Disorder, Aliases & Descriptions:

Name: Sleep Disorder 8 10
Non-Organic Sleep Disorder 8 62
 
Sleep Disorders 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:535
MeSH34 D012893
ICD9CM27 307.4
ICD1025 F51, G47, G47.9

Related Diseases for Sleep Disorder

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Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to sleep disorder

Symptoms for Sleep Disorder

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Drugs & Therapeutics for Sleep Disorder

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Drug clinical trials:

Search ClinicalTrials for Sleep Disorder

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Sleep Disorder

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Anatomical Context for Sleep Disorder

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MalaCards organs/tissues related to Sleep Disorder:

32
Testes, Heart, Brain, Lung, Eye, Whole blood, Cortex, Spinal cord, Kidney, Skin, Tonsil, Cingulate cortex, Hypothalamus, Tongue

Animal Models for Sleep Disorder or affiliated genes

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MGI Mouse Phenotypes related to Sleep Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8HCRT, HCRTR1, AANAT, HRH3, PER2
2MP:00053867.6HRH3, MTNR1A, HCRTR1, HCRT, PER2

Publications for Sleep Disorder

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Articles related to Sleep Disorder:

(show top 50)    (show all 415)
idTitleAuthorsYear
1
Spectrum of Sleep Disorders in a Patient with Spinocerebellar Ataxia 13. (25406272)
2014
2
Sleep disorder associated with antibodies to IgLON5: parasomnia or agrypnia? (25142452)
2014
3
Melatonin alterations and brain acetylcholine lesions in sleep disorders in Cockayne syndrome. (24503446)
2014
4
Sleep disorders and the interpersonal-psychological theory of suicide: independent pathways to suicidality? (24182416)
2014
5
Use of the Sleep Apnea Scale of the Sleep Disorders Questionnaire (SA-SDQ) in adults with epilepsy. (24397915)
2014
6
Effectiveness of the leukotriene receptor antagonist pranlukast hydrate for the treatment of sleep disorder in patients with perennial allergic rhinitis. (24460152)
2014
7
A two-year prospective study on the frequency and co-occurrence of insomnia and sleep-disordered breathing symptoms in a primary care population. (23777754)
2013
8
Prevalence and clinical correlates of sleep disordered breathing in myotonic dystrophy types 1 and 2. (24310756)
2013
9
Prader-Willi syndrome and sleep-disordered breathing. (24126982)
2013
10
Pathophysiological background and clinical characteristics of sleep disorders in multiple sclerosis. (24321163)
2013
11
Prevalence and symptoms of occult sleep disordered breathing among older veterans with insomnia. (24235899)
2013
12
Respiratory and sleep disorders in female children with atypical Rett syndrome caused by mutations in the CDKL5 gene. (23151060)
2013
13
Cardiac workload in patients with sleep-disordered breathing early after acute myocardial infarction. (23715560)
2013
14
Sleep disorders in children with Down syndrome. (23594294)
2013
15
Central sleep-disordered breathing and the effects of oxygen therapy in infants with Prader-Willi syndrome. (23761691)
2013
16
Increased prevalence of sleep-disordered breathing in Friedreich ataxia. (23700333)
2013
17
Fibromyalgia: gender differences and sleep-disordered breathing. (24373368)
2013
18
Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. (23917208)
2013
19
Sleep disordered breathing and other sleep dysfunction in myotonic dystrophy type 2. (22959494)
2012
20
Increased cysteinyl leukotriene concentration and receptor expression in tonsillar tissues of Chinese children with sleep-disordered breathing. (22634478)
2012
21
Effect of cognitive behavior therapy on sleep disorder in Parkinson's disease in China: a pilot study. (23186520)
2012
22
Free-running (non-entrained to 24-h period) circadian sleep disorder in a patient with obstructive sleep apnea, delayed sleep phase tendency, and lack of social interaction. (21594679)
2012
23
Stress and sleep disorder. (23319874)
2012
24
Legal issues encountered when treating the patient with a sleep disorder. (21208882)
2011
25
Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). (21337530)
2011
26
Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. (21211848)
2011
27
Cross-sectional study on relationship between constipation and medication in consideration of sleep disorder. (21804327)
2011
28
REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. (20022299)
2010
29
Shift work sleep disorder is associated with an attenuated brain response of sensory memory and an increased brain response to novelty: an ERP study. (20469813)
2010
30
Diagnostic pitfalls in children with sleep disorders: two cases with hypersomnia. (18754824)
2008
31
A diagnostic symptom profile for sleep disorder in primary care patients. (18374743)
2008
32
Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy. (17485650)
2007
33
Daytime hypoxemia, sleep-disordered breathing, and laryngopharyngeal findings in multiple system atrophy. (17562934)
2007
34
Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. (15791928)
2005
35
Survey of the present status of sleep-disordered breathing in children with achondroplasia Part I. A questionnaire survey. (15763281)
2005
36
Management of shift work sleep disorder: Alice in Wonderland redux? (15602174)
2004
37
Sleep, sleep disorders and hypocretin (orexin). (15301991)
2004
38
Neuropathology of tauopathies and synucleinopathies, and neuroanatomy of sleep disorders: meeting the challenge]. (14646802)
2003
39
Mayo study links heart rhythm problem to sleep disorder. (14619782)
2003
40
Article reviewed: REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (14592242)
2002
41
REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (11412865)
2001
42
Methylphenidate and melatonin for sleep disorder with optic glioma. (11556641)
2001
43
Law of denervation and spinal mechanism of leg movements in sleep. Commentary on controversies in sleep medicineMontplaisir et al.: Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopamineergic mechanism. (11438257)
2001
44
Sleep disorder, depression, and suicidality in female sexual assault survivors. (11419527)
2000
45
Microglia activation in a model of sleep disorder: an immunohistochemical study in the rat brain during Trypanosoma brucei infection. (10375652)
1999
46
Genetic factors in human sleep disorders with special reference to Norrie disease, Prader-Willi syndrome and Moebius syndrome. (10389102)
1999
47
Sleep disorders and anxiety: biochemical antecedents and pharmacological consequences. (7799254)
1994
48
Sleep disorder centers: how to plan a successful program. (1985846)
1991
49
The place of sleep disorder centers in the evaluation and treatment of chronic insomniacs. (6242984)
1981
50
Sleep disorder and psychosis. (5937820)
1966

Variations for Sleep Disorder

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Expression for genes affiliated with Sleep Disorder

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Expression patterns in normal tissues for genes affiliated with Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for genes affiliated with Sleep Disorder

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Compounds for genes affiliated with Sleep Disorder

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Compounds related to Sleep Disorder according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1isoflurane50 44 1111.9HCRTR1, HCRT
2s24014289.8MTNR1A, MTNR1B
35-heat289.8MTNR1B, MTNR1A
4s22153289.8MTNR1B, MTNR1A
5iik7289.8MTNR1B, MTNR1A
66-cl-mlt289.8MTNR1B, MTNR1A
7k185289.8MTNR1A, MTNR1B
8s20928289.8MTNR1B, MTNR1A
9gr 128107289.8MTNR1B, MTNR1A
10s24773289.8MTNR1B, MTNR1A
114p-pdot289.8MTNR1B, MTNR1A
12s26284289.8MTNR1B, MTNR1A
132-iodo-melatonin289.8MTNR1A, MTNR1B
142-iodomelatonin619.8MTNR1B, MTNR1A
15prazosin hydrochloride619.8MTNR1B, MTNR1A
164-p-pdot619.8MTNR1B, MTNR1A
17luzindole61 2810.8MTNR1B, MTNR1A
182-[125i]mlt289.8MTNR1A, MTNR1B
19s26131289.8MTNR1B, MTNR1A
20gr 196429289.7MTNR1B, MTNR1A
21[3h]melatonin289.7MTNR1B, MTNR1A
22ly 156735289.7MTNR1B, MTNR1A
23ramelteon28 44 1111.7MTNR1B, MTNR1A
24agomelatine44 28 1111.7MTNR1B, MTNR1A
25thapsigargin44 6110.7HCRTR1, HCRT
266-hydroxymelatonin28 44 2411.7MTNR1A, MTNR1B
27phosphoserine44 2410.6CSNK1A1L, AANAT
285-hydroxytryptamine449.6AANAT, HCRT
29amine449.1AANAT, HRH3
30acetylcholine44 50 28 24 1113.0HRH3, HCRTR1, HCRT
31nicotine44 28 50 1112.0HRH3, HCRT
32alanine449.0HCRT, HCRTR1, AANAT
33glutamate448.9HRH3, CSNK1A1L, HCRT
34norepinephrine44 24 1110.9HCRT, AANAT, HRH3
35dopamine44 28 24 1111.5HRH3, AANAT, HCRTR1, HCRT
36melatonin44 28 61 24 1112.5AANAT, MTNR1A, MTNR1B, HCRT, PER2

GO Terms for genes affiliated with Sleep Disorder

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Cellular components related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.1AANAT, HCRT, PER2
2integral component of plasma membraneGO:0058877.9HRH3, MTNR1A, MTNR1B, HCRTR1

Biological processes related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide signaling pathwayGO:0072189.4HCRT, HCRTR1
2eating behaviorGO:0427559.3HRH3, HCRT
3positive regulation of cytosolic calcium ion concentrationGO:0072049.3HCRT, HRH3
4synaptic transmissionGO:0072689.1HCRTR1, HCRT, MTNR1B
5circadian rhythmGO:0076239.0PER2, MTNR1A, AANAT
6G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071878.7HRH3, MTNR1A, MTNR1B

Molecular functions related to Sleep Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melatonin receptor activityGO:0085029.4MTNR1A, MTNR1B

Products for genes affiliated with Sleep Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Sleep Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet