MCID: SLP005
MIFTS: 59

Sleep Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Sleep Disorder

Summaries for Sleep Disorder

MedlinePlus : 40 Is it hard for you to fall asleep or stay asleep through the night? Do you wake up feeling tired or feel very sleepy during the day, even if you have had enough sleep? You might have a sleep disorder. The most common kinds are Insomnia - a hard time falling or staying asleep Sleep apnea - breathing interruptions during sleep Restless legs syndrome - a tingling or prickly sensation in the legs Narcolepsy - daytime "sleep attacks" Nightmares, night terrors, sleepwalking, sleep talking, head banging, wetting the bed and grinding your teeth are kinds of sleep problems called parasomnias. There are treatments for most sleep disorders. Sometimes just having good sleep habits can help.

MalaCards based summary : Sleep Disorder, also known as non-organic sleep disorder, is related to advanced sleep phase syndrome and sleep apnea, and has symptoms including sluggishness, sleeplessness and hot flushes. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are Circadian rythm related genes and Circadian rhythm. The drugs Ethanol and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are behavior/neurological and muscle

Disease Ontology : 12 A disease of mental health that involves disruption of sleep patterns.

Wikipedia : 72 A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some... more...

Related Diseases for Sleep Disorder

Diseases related to Sleep Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 advanced sleep phase syndrome 32.7 HCRT PER2 PER3
2 sleep apnea 32.1 CRP HCRT LEP
3 delayed sleep phase disorder 31.7 CRY1 PER2 PER3
4 periodic limb movement disorder 31.3 CTNNBL1 FXYD1
5 narcolepsy 30.7 CTNNBL1 HAPLN1 HCRT HCRTR1 HCRTR2 LEP
6 major depressive disorder 29.7 ANK3 CRY1 HCRT PRL
7 cluster headache 29.7 HCRT HCRTR2
8 rohhad 29.6 HCRT HCRTR1 HCRTR2
9 apnea, obstructive sleep 29.5 ARIH1 CRP CTNNBL1 HCRT LEP MMD
10 morbid obesity 29.5 CRP HCRT LEP
11 non 24 hour sleep wake disorder 11.7
12 mental retardation, autosomal recessive 37 11.4
13 idiopathic hypersomnia 11.2
14 rem sleep behavior disorder 11.1
15 machado-joseph disease 11.1
16 recurrent hypersomnia 11.0
17 bruxism 11.0
18 hypersomnia 11.0
19 chronic fatigue syndrome 11.0
20 angelman syndrome 11.0
21 creutzfeldt-jakob disease 10.9
22 progeroid short stature with pigmented nevi 10.9
23 advanced sleep phase syndrome, familial, 1 10.9
24 narcolepsy 1 10.8
25 short sleeper 10.8
26 chromosome 1q21.1 deletion syndrome, 1.35-mb 10.6
27 narcolepsy 7 10.6
28 neurodevelopmental disorder with severe motor impairment and absent language 10.6
29 lyme disease - neurological complications 10.6
30 hallucinogen dependence 10.3 HCRTR1 HCRTR2
31 melancholia 10.3 CRP PRL
32 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.2 CRP LEP
33 acute disseminated encephalomyelitis 10.2 HCRT MOG
34 acquired metabolic disease 10.1 CRP LEP PRL
35 body mass index quantitative trait locus 11 10.1
36 body mass index quantitative trait locus 9 10.1
37 body mass index quantitative trait locus 8 10.1
38 body mass index quantitative trait locus 7 10.1
39 body mass index quantitative trait locus 12 10.1
40 body mass index quantitative trait locus 14 10.1
41 body mass index quantitative trait locus 18 10.1
42 body mass index quantitative trait locus 4 10.0
43 body mass index quantitative trait locus 10 10.0
44 kleine-levin hibernation syndrome 10.0
45 central hypoventilation syndrome, congenital 10.0
46 epilepsy 10.0
47 neuromuscular disease 10.0
48 achondroplasia 10.0
49 restless legs syndrome 10.0
50 inherited metabolic disorder 10.0 CRP LEP MMD

Graphical network of the top 20 diseases related to Sleep Disorder:



Diseases related to Sleep Disorder

Symptoms & Phenotypes for Sleep Disorder

UMLS symptoms related to Sleep Disorder:


sluggishness, sleeplessness, hot flushes, vertigo/dizziness, hallucinations, hypnagogic, psychiatric symptom, chronic pain, vertigo, tremor, syncope, snoring, sleep disturbances, signs and symptoms, digestive, signs and symptoms, seizures, sciatica, pain, nightmares, nervousness, icterus, headache, fever, edema, dyspnea, cyanosis, cachexia, back pain

MGI Mouse Phenotypes related to Sleep Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 HAPLN1 HCRT HCRTR1 HCRTR2 LEP MOG
2 muscle MP:0005369 9.56 CRY1 FXYD1 HCRT HCRTR2 LEP MOG
3 nervous system MP:0003631 9.32 ANK3 CRY1 HCRT HCRTR1 HCRTR2 LEP

Drugs & Therapeutics for Sleep Disorder

Drugs for Sleep Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 764)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
2
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
4
Clonidine Approved Phase 4,Phase 2 4205-90-7 2803
5
Nitric Oxide Approved Phase 4 10102-43-9 145068
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-02-2 5743
7
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 60142-96-3 3446
8
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
9
Levodopa Approved Phase 4,Phase 2,Phase 3 59-92-7 6047
10
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1,Early Phase 1 439-14-5 3016
11
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-28-2 5757
12
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
15
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
16
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
17
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
18
Valproic Acid Approved, Investigational Phase 4,Phase 1,Phase 2 99-66-1 3121
19
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
20
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
21
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
22
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
23
Donepezil Approved Phase 4,Phase 3,Phase 2,Phase 1 120014-06-4 3152
24
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
25 Piracetam Approved, Investigational Phase 4,Phase 2 7491-74-9
26
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-45-6, 75614-87-8 774
27
Topiramate Approved Phase 4,Phase 1,Phase 2,Early Phase 1 97240-79-4 5284627
28
Hydroxychloroquine Approved Phase 4,Phase 2 118-42-3 3652
29
Mianserin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 24219-97-4 4184
30
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
32
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
33
Fluoxetine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54910-89-3 3386
34
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
35
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 5281004 63006
36
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
37
Diphenhydramine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-73-1, 147-24-0 3100
38
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2 59-66-5 1986
39
Amitriptyline Approved Phase 4,Phase 2,Phase 3 50-48-6 2160
40
Bupivacaine Approved, Investigational Phase 4,Phase 2 38396-39-3, 2180-92-9 2474
41
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
42
Pramipexole Approved, Investigational Phase 4,Phase 3,Phase 2 104632-26-0 119570 59868
43
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 6740-88-1 3821
44
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
45
Ropinirole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 91374-20-8, 91374-21-9 5095 497540
46
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 61869-08-7 43815
47
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Phase 1 85650-52-8, 61337-67-5 4205
48
Sertraline Approved Phase 4,Phase 2,Phase 3,Phase 1 79617-96-2 68617
49
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 9579578 4594
50
Lorazepam Approved Phase 4,Phase 3,Phase 2 846-49-1 3958

Interventional clinical trials:

(show top 50) (show all 3488)

# Name Status NCT ID Phase Drugs
1 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
2 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4 sodium alginate;esomeprazole
3 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
4 Validation of DaTscan for Detection of Parkinson Disease Related Disorders Unknown status NCT02138682 Phase 4 l-123 Ioflupane
5 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
6 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
7 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
8 Herbal Alternatives for Menopause Symptoms (HALT Study) Unknown status NCT00169299 Phase 4 Black cohosh;Multibotanical preparation;Multibotanical preparation + dietary soy counseling;Conjugated equine estrogen +/- medroxyprogesterone acetate
9 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status Unknown status NCT02135055 Phase 4 Midazolam;Morphine
10 Levetiracetam Treatment of Children With Subclinical Sleep-Activated Epileptiform Activity (SSEA) Unknown status NCT00393614 Phase 4 levetiracetam
11 Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
12 Efficacy and Safety of 5 mg Sublingual Zolpidem vs 10mg Oral Zolpidem in the Induction and Maintenance of Sleep in Patients With Primary Insomnia Unknown status NCT01896336 Phase 4 Zolpidem Hemitartrate
13 Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia Unknown status NCT01180855 Phase 4 Placebo;Rozerem 8mg
14 Study to Observe the Effect of Mirapex ER® Once-daily (QD) Versus Twice-daily (BID) Unknown status NCT01515774 Phase 4 Mirapex ER
15 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
16 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
17 Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans Unknown status NCT01662297 Phase 4 Quetiapine;Trazodone
18 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
19 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4 Rotigotine;Placebo patchs
20 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
21 Effect of Atomoxetine on ADHD-Related Insomnia in Children and Adolescents Unknown status NCT00252278 Phase 4 atomoxetine
22 A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia Unknown status NCT02669030 Phase 4 suvorexant;Placebo
23 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
24 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
25 Intermittent Hypoxia 2: Cardiovascular and Metabolism Unknown status NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
26 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
27 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
28 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
29 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
30 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
31 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
32 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
33 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
34 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
35 Treatment of Cheyne Stocks Respiration With Adaptive Servo Ventilation and Bilevel Ventilators in Patients With Chronic Heart Failure Unknown status NCT00725595 Phase 4
36 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
37 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
38 Effects of Zolpidem CR® in Sleep and Heart Recovery in Cardiac Intensive Care Unit Patients Unknown status NCT01920334 Phase 4 Zolpidem CR 12.5mg;Placebo
39 Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression Unknown status NCT00291239 Phase 4
40 Sleep Disorders and Gastroesophageal Reflux Disease (GERD) Completed NCT00287391 Phase 4 Rabeprazole
41 Atripla to Stribild Switch Study to Evaluate Sleep Disturbances Completed NCT02477527 Phase 4 Stribild
42 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Milnacipran
43 Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease Completed NCT01442610 Phase 4 Rasagiline;Placebo
44 A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS Completed NCT00349531 Phase 4 Pramipexole
45 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disea Completed NCT00628342 Phase 4 Esomeprazole;Esomeprazole;Placebo
46 Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder Completed NCT00120250 Phase 4 Eszopiclone
47 Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation Completed NCT03116841 Phase 4 Vonoprazan
48 Prazosin Treatment for Combat Trauma PTSD (Post-Traumatic Stress Disorder) Nightmares and Sleep Disturbance Completed NCT00108420 Phase 4 Prazosin
49 Mometasone Furoate on Sleep Disturbances in Subjects With Seasonal Allergic Rhinitis (Study P04608) (COMPLETED) Completed NCT00358527 Phase 4 Mometasone Furoate Nasal Spray (MFNS)
50 An Efficacy and Safety Study of Hydromorphone Oral Osmotic System (OROS) in Korean Participants With Cancer Pain Completed NCT00766831 Phase 4 Hydromorphone

Search NIH Clinical Center for Sleep Disorder

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Sleep Disorder

Anatomical Context for Sleep Disorder

MalaCards organs/tissues related to Sleep Disorder:

38
Heart, Brain, Testes, Endothelial, Kidney, Lung, Liver

Publications for Sleep Disorder

Articles related to Sleep Disorder:

(show top 50) (show all 547)
# Title Authors Year
1
Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat. ( 29170000 )
2018
2
Severe obstructive sleep disorders in Prader-Willi syndrome patients in southern Italy. ( 29318372 )
2018
3
Shift work and sleep disorder comorbidity tend to go hand in hand. ( 29157012 )
2018
4
Assessing the sleeping habits of patients in a sleep disorder centre: a review of sleep diary accuracy. ( 29445542 )
2018
5
Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice. ( 29288667 )
2018
6
Non-Apnea Sleep Disorder Increases the Risk of Subsequent Female Infertility-A Nationwide Population-Based Cohort Study. ( 29136234 )
2018
7
The clinical usefulness of a self-administered questionnaire for sleep-disordered breathing in patients with neuromuscular disease. ( 29445539 )
2018
8
Serum brain-derived neurotrophic factor levels and sleep disorders in Chinese healthy and newly diagnosed type 2 diabetic subjects. ( 27038292 )
2017
9
Sleep disordered breathing in children with achondroplasia. ( 27830579 )
2017
10
Refractory sleep-disordered breathing due to unilateral lingual tonsillar hypertrophy in a child with Proteus Syndrome. ( 28576518 )
2017
11
Feasibility of a respiratory nurse specialist-led sleep disorder service in a district general hospital. ( 28675190 )
2017
12
Pathophysiology, evaluation, and management of sleep disorders in the mucopolysaccharidoses. ( 28964643 )
2017
13
Hyperbaric oxygen therapy is safe and effective for the treatment of sleep disorders in children with cerebral palsy. ( 28079475 )
2017
14
Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in DialysisA Patients. ( 27693261 )
2017
15
Sleep-Disordered Breathing During Congestive Heart Failure: To Intervene or Not to Intervene? ( 29387467 )
2017
16
REM sleep disorder following general anesthesia in rats. ( 27771371 )
2017
17
Incidence of Prosthetic Complications associated with Implant-borne Prosthesis in a Sleep Disorder Center. ( 28874648 )
2017
18
Association between sleep disorder and panic disorder in South Korea: Nationwide nested case-control study of data from 2004 to 2013. ( 29223044 )
2017
19
Dissociation of Objective and Subjective Daytime Sleepiness and Biomarkers of Systemic Inflammation in Sleep-Disordered Breathing and Systolic Heart Failure. ( 29065958 )
2017
20
Understanding the different relationships between mood and sleep disorders in several groups of non-oncological patients with chronic pain. ( 28945136 )
2017
21
Natural course and potential prognostic factors for sleep-disordered breathing in multiple system atrophy. ( 28522081 )
2017
22
Trauma associated sleep disorder: A parasomnia induced by trauma. ( 28363448 )
2017
23
Sleep Disorder as a Triggering Factor for Relapse in Multiple Sclerosis. ( 28359058 )
2017
24
Sleep Disordered Breathing and Magnetic Resonance Imaging Findings in Children With Chiari Malformation Type I. ( 28943363 )
2017
25
Sleep disordered breathing does not predict acute severe pain episodes in children with sickle cell anemia. ( 29266432 )
2017
26
Sleep disorder diagnoses and clinical outcomes among hospitalized breast cancer patients: a nationwide inpatient sample study. ( 29264658 )
2017
27
Sleep-disordered breathing in patients with neuromuscular disease. ( 28702830 )
2017
28
Sleep-Disordered Breathing among Newborns with Myelomeningocele. ( 29221695 )
2017
29
Sleep Disorders: Restless Legs Syndrome. ( 28845959 )
2017
30
Dante Alighieri: evidence for sleep disorder-related cardiac autonomic dysfunctions. ( 28000594 )
2017
31
Sleep disordered breathing in Bardet-Biedl Syndrome. ( 29106859 )
2017
32
The influence of sleep disordered breathing in REM sleep behavior disorder. ( 28673760 )
2017
33
Sleep-Disordered Breathing in Neuromuscular Disease: Diagnostic and Therapeutic Challenges. ( 28372949 )
2017
34
Risk factors of sleep disorder after stroke: a meta-analysis. ( 27686181 )
2017
35
Sleep disorder, an independent risk associated with arterial stiffness in menopause. ( 28507296 )
2017
36
Sleep-disordered breathing and its management in children with achondroplasia. ( 28239978 )
2017
37
Spa therapy (balneotherapy) relieves mental stress, sleep disorder, and general health problems in sub-healthy people. ( 28936572 )
2017
38
Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth. ( 28796676 )
2017
39
Epilepsy and sleep disorders improve in adolescents and adults with Angelman syndrome: A multicenter study on 46 patients. ( 28827041 )
2017
40
The National Veteran Sleep Disorder Study: Descriptive Epidemiology and Secular Trends, 2000-2010. ( 27091538 )
2016
41
Parkinson disease. Sleep disorder deficits suggest signature for early Parkinson disease. ( 26635212 )
2016
42
Shift Work and Shift Work Sleep Disorder: Clinical and Organizational Perspectives. ( 28012806 )
2016
43
Does the Type of Multisystem Atrophy, Parkinsonism, or Cerebellar Ataxia Impact on the Nature of Sleep Disorders? ( 27844341 )
2016
44
The Relationship Between Sleep-Disordered Breathing Severity and Daytime Adaptive Functioning in Children with Down Syndrome. ( 27637582 )
2016
45
Sleep-Disordered Breathing in Patients with Pulmonary Valve Incompetence Complicating Congenital Heart Disease. ( 27214563 )
2016
46
Agreement of the International Classification of Sleep Disorders Criteria with polysomnography for sleep bruxism diagnosis: A preliminary study. ( 27460312 )
2016
47
An observational clinical and video-polysomnographic study of the effects of rotigotine in sleep disorder in Parkinson's disease. ( 27726069 )
2016
48
Sleep disorders in Machado-Joseph disease. ( 27584711 )
2016
49
Relationships between nutritional knowledge, obesity, and sleep disorder severity. ( 26843133 )
2016
50
Evaluation of sleep disorder and its effect on sexual dysfunction in patients with Fibromyalgia syndrome. ( 28913116 )
2016

Variations for Sleep Disorder

Expression for Sleep Disorder

Search GEO for disease gene expression data for Sleep Disorder.

Pathways for Sleep Disorder

Pathways related to Sleep Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
2
Show member pathways
10.97 CRY1 PER2 PER3
3 10.7 CRY1 PER2 PER3

GO Terms for Sleep Disorder

Biological processes related to Sleep Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 rhythmic process GO:0048511 9.7 CRY1 PER2 PER3
2 glucose homeostasis GO:0042593 9.65 CRY1 LEP TFAP2B
3 regulation of insulin secretion GO:0050796 9.58 LEP PER2 TFAP2B
4 circadian regulation of gene expression GO:0032922 9.54 CRY1 PER2 PER3
5 positive regulation of JAK-STAT cascade GO:0046427 9.51 LEP PRL
6 response to peptide GO:1901652 9.49 HCRTR1 HCRTR2
7 negative regulation of lipid storage GO:0010888 9.46 CRP LEP
8 neuropeptide signaling pathway GO:0007218 9.46 HCRT HCRTR1 HCRTR2 NPS
9 negative regulation of circadian rhythm GO:0042754 9.43 CRY1 PER2
10 feeding behavior GO:0007631 9.43 HCRT HCRTR1 HCRTR2
11 magnesium ion homeostasis GO:0010960 9.32 ANK3 TFAP2B
12 circadian rhythm GO:0007623 9.26 CRY1 LEP PER2 PER3
13 regulation of circadian sleep/wake cycle, sleep GO:0045187 8.8 HCRTR1 HCRTR2 PER3

Molecular functions related to Sleep Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, transcription factor binding GO:0000989 8.96 CRY1 PER2
2 orexin receptor activity GO:0016499 8.62 HCRTR1 HCRTR2

Sources for Sleep Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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