MCID: SLP001
MIFTS: 49

Sleeping Sickness malady

Infectious diseases, Rare diseases categories

Summaries for Sleeping Sickness

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NINDS:42 Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma. Patients may also experience abnormal eye movements, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosis. The cause of encephalitis lethargica is unknown. Between 1917 to 1928, an epidemic of encephalitis lethargica spread throughout the world, but no recurrence of the epidemic has since been reported. Postencephalitic Parkinson's disease may develop after a bout of encephalitis-sometimes as long as a year after the illness.

MalaCards based summary: Sleeping Sickness, also known as african trypanosomiasis, is related to leishmaniasis and malaria. An important gene associated with Sleeping Sickness is APOL1 (apolipoprotein L, 1), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Cytokine Network. The drugs eflornithine and eflornithine hydrochloride and the compounds ethylglyoxal-bis-guanylhydrazone and abeado have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are liver/biliary system and mortality/aging.

Disease Ontology:9 A trypanosomiasis that results from infection by trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (glossina spp). the symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.

CDC:3 African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly (Glossina species), which is found only in rural Africa. Although the infection is not found in the United States, historically, it has been a serious public health problem in some regions of sub-Saharan Africa. Currently, about 10,000 new cases each year are reported to the World Health organization; however, it is believed that many cases go undiagnosed and unreported. Sleeping sickness is curable with medication, but is fatal if left untreated.

Aliases & Classifications for Sleeping Sickness

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Sources:
9Disease Ontology, 42NINDS, 11DISEASES, 47Orphanet, 3CDC, 60UMLS, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Sleeping Sickness, Aliases & Descriptions:

Name: Sleeping Sickness 9 42 11 47 3
African Trypanosomiasis 9 47 3 60
 
African Sleeping Sickness 9
Trypanosomiasis African 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

47
sleeping sickness:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:10112
ICD9CM27 086.5
MeSH33 D014353
NCIt38 C84541
Orphanet47 3385
MESH via Orphanet34 D014353
ICD10 via Orphanet26 B56.0, B56.1, B56.9
UMLS via Orphanet61 C0041228
ICD1025 B56

Related Diseases for Sleeping Sickness

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Diseases related to Sleeping Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.9SRM, MDH2, IL10
2malaria30.8IL10, NOS2
3chagas disease30.6SRM, ODC1, AMD1, GAPDH
4trypanosomiasis10.8
5choroiditis10.4
6cerebritis10.3
7hiv-110.2
8amebiasis10.2
9orchitis10.2
10endomyocardial fibrosis10.2
11onchocerciasis10.2
12pseudobulbar palsy10.2
13filariasis10.2
14microsporidiosis10.2
15schistosomiasis10.2
16endotheliitis10.2
17myoepithelioma10.1GFAP, NOS2
18kidney disease10.1IL6, APOL1, HPR
19hepatitis c virus10.1
20hepatitis10.1
21hepatitis c10.1
22narcolepsy10.1
23neuronitis10.1
24viral encephalitis10.1
25visceral leishmaniasis10.1
26encephalitis10.1
27hypogonadism10.1
28trypanosomiasis, human east-african10.1
29trypanosomiasis, human west-african10.1
30thrombocytopenia10.1IL6, ABCB7, HPR
31pleomorphic adenoma10.0NOS2, GFAP
32liver disease10.0HPR, IL6, IL10
33prion disease10.0GFAP, NOS2, ODC1
34diabetes mellitus, insulin-dependent10.0NOS2, IL10
35acute pancreatitis10.0IL6, ABCB7, IL10
36congenital heart disease9.9IL10, IL6, HPR
37plasmodium falciparum malaria9.9IL10, NOS2
38meningioma, familial9.9ODC1, GAPDH, GFAP
39acute respiratory distress syndrome9.9IL6, NOS2
40colitis9.8NOS2, IL6, IL10
41deficiency anemia9.8GAPDH, HPR, IL6, ABCB7
42ulcerative colitis9.7IL10, NOS2, IL6
43arthritis9.7NOS2, HPR, IL6, IL10
44tuberculosis9.7GAPDH, HPR, IL10, MDH2
45multiple sclerosis, disease progression, modifier of9.7GFAP, IL6, IL10, NOS2
46glioblastoma9.6GFAP, GAPDH, NOS2, ODC1
47astrocytoma9.6NOS2, GAPDH, IL6, GFAP
48preeclampsia/eclampsia 19.5IL10, IL6, GAPDH, NOS2
49ipex syndrome9.4ABCB7, AMD1, IL6, GAPDH, DNAJB1, IL10
50vascular disease9.2NOS2, GAPDH, GFAP, HPR, IL10, IL6

Graphical network of the top 20 diseases related to Sleeping Sickness:



Diseases related to sleeping sickness

Symptoms for Sleeping Sickness

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Drugs & Therapeutics for Sleeping Sickness

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Drug clinical trials:

Search ClinicalTrials for Sleeping Sickness

Search NIH Clinical Center for Sleeping Sickness

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Sleeping Sickness

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Anatomical Context for Sleeping Sickness

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MalaCards organs/tissues related to Sleeping Sickness:

31
Eye, Testes, Brain, Heart, Salivary gland, Testis, T cells, Pituitary

Animal Models for Sleeping Sickness or affiliated genes

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MGI Mouse Phenotypes related to Sleeping Sickness:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8NOS2, GAPDH, IL6, IL10, ABCB7
2MP:00107687.6NOS2, ABCB7, GFAP, ODC1, AMD1, IL10

Publications for Sleeping Sickness

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Articles related to Sleeping Sickness:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Costs of using "tiny targets" to control Glossina fuscipes fuscipes, a vector of gambiense sleeping sickness in Arua District of Uganda. (25811956)
2015
2
Closing in on a new treatment for sleeping sickness. (23853715)
2013
3
Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda. (23841963)
2013
4
Secreted proteases of Trypanosoma brucei gambiense: possible targets for sleeping sickness control? (23553721)
2013
5
Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness. (23469311)
2013
6
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
7
The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness. (21956798)
2011
8
Clinical presentation of T.b. rhodesiense sleeping sickness in second stage patients from Tanzania and Uganda. (21407802)
2011
9
Tsetse elimination: its interest and feasibility in the historical sleeping sickness focus of Loos islands, Guinea. (19353949)
2009
10
The interaction of an antiparasitic peptide active against African sleeping sickness with cell membrane models. (19729286)
2009
11
The natural progression of Gambiense sleeping sickness: what is the evidence? (19104656)
2008
12
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
13
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
14
Public-private partnership works to stamp out sleeping sickness in Uganda. (17392023)
2007
15
Using remote sensing and geographic information systems to identify villages at high risk for rhodesiense sleeping sickness in Uganda. (16246384)
2006
16
Capacity of community-based organisations to disseminate sleeping sickness information. (16261917)
2005
17
Retaking sleeping sickness control in Angola. (14728618)
2004
18
Mixed infections of trypanosomes in tsetse and pigs and their epidemiological significance in a sleeping sickness focus of CA'te d'Ivoire. (15648692)
2004
19
Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in CA'te d'Ivoire: a new genetic group? (15228714)
2004
20
Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness. (14733670)
2003
21
Researches on the etiology of sleeping sickness. 1903. (15272468)
2003
22
The challenge of Trypanosoma brucei gambiense sleeping sickness diagnosis outside Africa. (14652206)
2003
23
Characterization of Trypanosoma brucei s.l. subspecies by isoenzymes in domestic pigs from the Fontem sleeping sickness focus of Cameroon. (11835899)
2002
24
IgM quantification in the cerebrospinal fluid of sleeping sickness patients by a latex card agglutination test. (12167095)
2002
25
African sleeping sickness in tourists returning from Tanzania: the first 2 Italian cases from a small outbreak among European travelers. (11731969)
2002
26
Sleeping sickness resurgence in the DRC: the past decade. (11348528)
2001
27
African sleeping sickness returns to UK after four years. (11073504)
2000
28
Sleeping sickness in Sri Lanka. (11006622)
2000
29
Isolation of Trypanosoma brucei from the monitor lizard (Varanus niloticus) in an endemic focus of Rhodesian sleeping sickness in Kenya. (10206114)
1999
30
Duration of symptoms and case fatality of sleeping sickness caused by Trypanosoma brucei rhodesiense in Tororo, Uganda. (9557424)
1997
31
Metronidazole and suramin combination in the treatment of arsenical refractory Rhodesian sleeping sickness--a case study. (8882195)
1996
32
Relapses following treatment of early-stage Trypanosoma brucei gambiense sleeping sickness with a combination of pentamidine and suramin. (8761585)
1996
33
Sensitivity of animal-derived Trypanozoon stocks from sleeping sickness endemic foci of Nigeria to trypanocides and human plasma. (8552843)
1995
34
Risk factors assessment for T. b. rhodesiense sleeping sickness acquisition in S.E. Uganda. A case-control study. (7944647)
1994
35
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
36
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. (7932587)
1994
37
Diagnosis of Trypanosoma brucei gambiense sleeping sickness using an antigen detection enzyme-linked immunosorbent assay. (1566302)
1992
38
African sleeping sickness: an historical review. (1782243)
1991
39
A new method for isolating Trypanosoma brucei gambiense from sleeping sickness patients. (2617625)
1989
40
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
41
Death camps in the Congo: administrative responses to sleeping sickness 1903-1911. (11611572)
1984
42
Sleeping sickness in Iganga District, Uganda: application of a new diagnostic technique. (7318723)
1981
43
Palaeoecology of Tsetse flies and sleeping sickness in Africa. (11610781)
1980
44
Settlement and sleeping sickness control--a dual threshold model of colonial and traditional methods in East Africa. (524124)
1979
45
The penetrative ability of sleeping-sickness trypanosomes. (734725)
1978
46
Lymphocytic infiltration of the brain in sleeping sickness. (1087170)
1976
47
The complex epidemiology of Rhodesian sleeping sickness in Kenya and Uganda. I. The absence of the disease on Mfangano Island (Kenya). (4830620)
1974
48
Letter: Sleeping sickness. (4852929)
1974
49
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
50
New animal reservoirs of T. rhodesiense sleeping sickness. (4147877)
1973

Variations for Sleeping Sickness

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Expression for genes affiliated with Sleeping Sickness

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Search GEO for disease gene expression data for Sleeping Sickness.

Pathways for genes affiliated with Sleeping Sickness

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Pathways related to Sleeping Sickness according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL6, NOS2
29.9IL6, IL10
39.9IL6, IL10
4
Show member pathways
creatine-phosphate biosynthesis36
glycine degradation (creatine biosynthesis)36
putrescine biosynthesis III36
spermidine biosynthesis I36
tryptophan degradation via kynurenine36
spermine biosynthesis36
urea cycle36
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I36
tyrosine degradation I36
L-carnitine biosynthesis36
methylthiopropionate biosynthesis36
2-oxoglutarate decarboxylation to succinyl-CoA36
S-methyl-5-thioadenosine degradation II36
9.7SRM, AMD1, ODC1
59.6NOS2, IL6, GFAP
69.6NOS2, IL6, IL10
79.6IL10, IL6, NOS2
8
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.6IL10, IL6, NOS2
9
Show member pathways
9.6IL10, IL6, NOS2
109.6IL10, IL6, NOS2
11
Show member pathways
citrulline-nitric oxide cycle36
arginine degradation I (arginase pathway)36
proline degradation36
glutamine degradation I36
proline biosynthesis I36
superpathway of citrulline metabolism36
proline biosynthesis II (from arginine)36
citrulline biosynthesis36
arginine degradation VI (arginase 2 pathway)36
Urea cycle and metabolism of amino groups36
asparagine biosynthesis I36
4-hydroxyproline degradation I36
citrulline degradation36
9.4ODC1, AMD1, SRM, NOS2
129.3NOS2, GAPDH, IL6
139.3GAPDH, IL6, IL10
14
Show member pathways
9.3MDH2, SRM, AMD1
159.2HPR, IL6, IL10, APOL1
16
Show member pathways
8.0ABCB7, ODC1, AMD1, SRM, GAPDH, NOS2

Compounds for genes affiliated with Sleeping Sickness

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Compounds related to Sleeping Sickness according to GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ethylglyoxal-bis-guanylhydrazone4310.4AMD1, ODC1
2abeado4310.4AMD1, ODC1
3methylglyoxal bis(guanylhydrazone)4310.4ODC1, AMD1
4sam 486a4310.3ODC1, AMD1
51-aminooxy-3-aminopropane4310.3SRM, ODC1
6S-Adenosylmethioninamine2410.3SRM, AMD1
7n(g)-hydroxy-l-arginine4310.3NOS2, ODC1
81,3-diaminopropane43 2411.2AMD1, ODC1
9cdp5714310.1IL6, IL10
10cadaverine43 2411.1AMD1, ODC1, SRM
11dfmo43 28 5912.1ODC1, AMD1, SRM
12putrescine43 28 24 1213.1SRM, ODC1, AMD1
13rebamipide4310.0IL6, NOS2
14spermidine43 28 24 1213.0SRM, ODC1, AMD1
152,5-oligoadenylate4310.0IL6, IL10, ODC1
16polyinosinic-polycytidylic acid439.9IL10, NOS2, IL6
17spermine28 43 24 1212.9ODC1, AMD1, SRM
18fluvastatin43 49 28 1212.9ABCB7, NOS2, IL6
19deet439.9NOS2, GAPDH, ODC1
20diisopropylfluorophosphate439.8ODC1, GAPDH, GFAP
21gsno439.8GAPDH, ODC1, NOS2
22taurine chloramine439.8IL6, GAPDH, NOS2
23citrulline43 2410.8NOS2, IL10, GAPDH
2415-deoxy-delta-12,14-prostaglandin j2439.8IL6, NOS2, IL10
25trypanothione43 1210.6SRM, ODC1
264-hydroxynonenal43 2410.5IL10, NOS2, ODC1, GAPDH
27peroxynitrite439.5GFAP, GAPDH, NOS2
28sb 20358043 5910.4NOS2, IL6, IL10, ODC1
29nmda43 2810.4GFAP, ODC1, AMD1, GAPDH, NOS2
30n acetylcysteine439.3ODC1, IL6, GAPDH, NOS2
31pge2439.2NOS2, GAPDH, ODC1, IL10, IL6
32glyceraldehyde 3-phosphate439.2MDH2, ODC1, GFAP, GAPDH
33methionine439.2ODC1, SRM, GFAP, HPR
34polyacrylamide439.1ABCB7, GFAP, GAPDH, MDH2
35ly294002439.0IL6, NOS2, GAPDH, IL10
36adenylate439.0NOS2, ODC1, GFAP, HPR, GAPDH
37ornithine43 2410.0MDH2, GAPDH, ODC1, SRM, AMD1
38creatinine438.9MDH2, IL6, GFAP, ABCB7, GAPDH
39testosterone43 59 24 1211.8ABCB7, ODC1, HPR, GAPDH, GFAP, IL6
40glutamine438.8GFAP, MDH2, ODC1, DNAJB1, GAPDH
41nitric oxide43 24 1210.8NOS2, GAPDH, IL10, ABCB7, ODC1, IL6
42cycloheximide438.8AMD1, GFAP, IL10, IL6, GAPDH, NOS2
43dexamethasone43 49 28 1211.7HPR, GFAP, IL10, IL6, NOS2
44aspartate438.7IL10, ODC1, GFAP, ABCB7, GAPDH, MDH2
45lactate438.7ABCB7, MDH2, GAPDH, ODC1, IL6, GFAP
46estrogen438.7GFAP, HPR, GAPDH, IL6, ODC1, NOS2
47glutamate438.7ODC1, ABCB7, GFAP, GAPDH, NOS2, MDH2
48glucose438.3GAPDH, GFAP, IL6, HPR, MDH2, ABCB7
49alanine438.3AMD1, ABCB7, GFAP, IL6, HPR, GAPDH
50atp43 289.3GFAP, DNAJB1, GAPDH, MDH2, HPR, ABCB7

GO Terms for genes affiliated with Sleeping Sickness

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Biological processes related to Sleeping Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spermidine biosynthetic processGO:000829510.0SRM, AMD1
2polyamine metabolic processGO:00065959.8SRM, AMD1, ODC1
3cellular nitrogen compound metabolic processGO:00346419.7SRM, AMD1, ODC1
4defense response to Gram-negative bacteriumGO:00508299.6IL6, NOS2
5cellular response to interferon-gammaGO:00713469.6GAPDH, NOS2
6small molecule metabolic processGO:00442818.3ABCB7, ODC1, AMD1, SRM, GAPDH, MDH2

Products for genes affiliated with Sleeping Sickness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Sleeping Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet