MCID: SLP001
MIFTS: 58

Sleeping Sickness malady

Infectious diseases, Rare diseases categories
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Summaries for Sleeping Sickness

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NINDS:43 Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma. Patients may also experience abnormal eye movements, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosis. The cause of encephalitis lethargica is unknown. Between 1917 to 1928, an epidemic of encephalitis lethargica spread throughout the world, but no recurrence of the epidemic has since been reported. Postencephalitic Parkinson's disease may develop after a bout of encephalitis-sometimes as long as a year after the illness.

MalaCards based summary: Sleeping Sickness, also known as african trypanosomiasis, is related to leishmaniasis and chagas disease. An important gene associated with Sleeping Sickness is APOL1 (apolipoprotein L, 1), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Cytokine Network. The drugs eflornithine and eflornithine hydrochloride and the compounds ethylglyoxal-bis-guanylhydrazone and abeado have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are liver/biliary system and mortality/aging.

Disease Ontology:8 A trypanosomiasis that results from infection by trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (glossina spp). the symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.

CDC:3 African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly (Glossina species), which is found only in rural Africa. Although the infection is not found in the United States, historically, it has been a serious public health problem in some regions of sub-Saharan Africa. Currently, about 10,000 new cases each year are reported to the World Health organization; however, it is believed that many cases go undiagnosed and unreported. Sleeping sickness is curable with medication, but is fatal if left untreated.

Aliases & Classifications for Sleeping Sickness

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Sources:
8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Sleeping Sickness, Aliases & Descriptions:

Name: Sleeping Sickness 8 43 10 48
African Trypanosomiasis 8 48 62
 
African Sleeping Sickness 8 62
Trypanosomiasis African 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
sleeping sickness:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:10112
NCIt39 C84541
MeSH34 D014353
ICD9CM27 086.5
MESH via Orphanet35 D014353
ICD10 via Orphanet26 B56.0, B56.1, B56.9
UMLS via Orphanet63 C0041228
ICD1025 B56

Related Diseases for Sleeping Sickness

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Diseases related to Sleeping Sickness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.9SRM, MDH2, IL10
2chagas disease30.6SRM, ODC1, AMD1, GAPDH
3cerebral malaria30.1IL10, NOS2
4malaria30.1SRM, IL10, HPR, GAPDH, AMD1, ODC1
5trypanosomiasis10.8
6choroiditis10.4
7cerebritis10.3
8trypanosomiasis, human east-african10.2
9hiv-110.2
10orchitis10.2
11endomyocardial fibrosis10.2
12amebiasis10.2
13onchocerciasis10.2
14pseudobulbar palsy10.2
15filariasis10.2
16microsporidiosis10.2
17schistosomiasis10.2
18endotheliitis10.2
19myoepithelioma10.1GFAP, NOS2
20primary hyperoxaluria10.1IL6, APOL1, HPR
21hepatitis10.1
22hepatitis c10.1
23viral encephalitis10.1
24visceral leishmaniasis10.1
25narcolepsy10.1
26eastern equine encephalitis10.1
27encephalitis10.1
28hypogonadism10.1
29trypanosomiasis, human west-african10.1
30hepatitis c virus10.1
31adrenocortical insufficiency10.1
32thrombocytopenia10.1IL6, ABCB7, HPR
33pleomorphic adenoma10.0NOS2, GFAP
34galactosemia10.0HPR, IL6, IL10
35prion disease10.0GFAP, NOS2, ODC1
36type 1 diabetes mellitus10.0NOS2, IL10
37acute pancreatitis10.0IL6, ABCB7, IL10
38congenital heart disease9.9IL10, IL6, HPR
39plasmodium falciparum malaria9.9IL10, NOS2
40meningioma9.9ODC1, GAPDH, GFAP
41adult respiratory distress syndrome9.9IL6, NOS2
42colitis9.9NOS2, IL6, IL10
43deficiency anemia9.8GAPDH, HPR, IL6, ABCB7
44ulcerative colitis9.7IL10, NOS2, IL6
45arthritis9.7NOS2, HPR, IL6, IL10
46tuberculosis9.7GAPDH, HPR, IL10, MDH2
47multiple sclerosis9.7GFAP, IL6, IL10, NOS2
48glioblastoma9.6GFAP, GAPDH, NOS2, ODC1
49astrocytoma9.6NOS2, GAPDH, IL6, GFAP
50septic shock9.5NOS2, GAPDH, IL6, IL10

Graphical network of the top 20 diseases related to Sleeping Sickness:



Diseases related to sleeping sickness

Symptoms for Sleeping Sickness

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Drugs & Therapeutics for Sleeping Sickness

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Drug clinical trials:

Search ClinicalTrials for Sleeping Sickness

Search NIH Clinical Center for Sleeping Sickness

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Sleeping Sickness

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Anatomical Context for Sleeping Sickness

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MalaCards organs/tissues related to Sleeping Sickness:

32
Eye, Testes, Brain, Heart, Salivary gland, Testis, T cells, Pituitary

Animal Models for Sleeping Sickness or affiliated genes

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MGI Mouse Phenotypes related to Sleeping Sickness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8NOS2, GAPDH, IL6, IL10, ABCB7
2MP:00107687.6NOS2, ABCB7, GFAP, ODC1, AMD1, IL10

Publications for Sleeping Sickness

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Articles related to Sleeping Sickness:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Closing in on a new treatment for sleeping sickness. (23853715)
2013
2
Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda. (23841963)
2013
3
Secreted proteases of Trypanosoma brucei gambiense: possible targets for sleeping sickness control? (23553721)
2013
4
Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness. (23469311)
2013
5
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
6
The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness. (21956798)
2011
7
Clinical presentation of T.b. rhodesiense sleeping sickness in second stage patients from Tanzania and Uganda. (21407802)
2011
8
Experiences with an in-training community service model in the control of zoonotic sleeping sickness in Uganda. (20847337)
2010
9
Tsetse elimination: its interest and feasibility in the historical sleeping sickness focus of Loos islands, Guinea. (19353949)
2009
10
The interaction of an antiparasitic peptide active against African sleeping sickness with cell membrane models. (19729286)
2009
11
The natural progression of Gambiense sleeping sickness: what is the evidence? (19104656)
2008
12
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
13
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
14
Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness. (17331943)
2007
15
Public-private partnership works to stamp out sleeping sickness in Uganda. (17392023)
2007
16
Using remote sensing and geographic information systems to identify villages at high risk for rhodesiense sleeping sickness in Uganda. (16246384)
2006
17
Capacity of community-based organisations to disseminate sleeping sickness information. (16261917)
2005
18
Retaking sleeping sickness control in Angola. (14728618)
2004
19
Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in CA'te d'Ivoire: a new genetic group? (15228714)
2004
20
Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness. (14733670)
2003
21
Researches on the etiology of sleeping sickness. 1903. (15272468)
2003
22
The challenge of Trypanosoma brucei gambiense sleeping sickness diagnosis outside Africa. (14652206)
2003
23
Characterization of Trypanosoma brucei s.l. subspecies by isoenzymes in domestic pigs from the Fontem sleeping sickness focus of Cameroon. (11835899)
2002
24
IgM quantification in the cerebrospinal fluid of sleeping sickness patients by a latex card agglutination test. (12167095)
2002
25
African sleeping sickness in tourists returning from Tanzania: the first 2 Italian cases from a small outbreak among European travelers. (11731969)
2002
26
Sleeping sickness resurgence in the DRC: the past decade. (11348528)
2001
27
African sleeping sickness returns to UK after four years. (11073504)
2000
28
Sleeping sickness in Sri Lanka. (11006622)
2000
29
Isolation of Trypanosoma brucei from the monitor lizard (Varanus niloticus) in an endemic focus of Rhodesian sleeping sickness in Kenya. (10206114)
1999
30
Duration of symptoms and case fatality of sleeping sickness caused by Trypanosoma brucei rhodesiense in Tororo, Uganda. (9557424)
1997
31
Metronidazole and suramin combination in the treatment of arsenical refractory Rhodesian sleeping sickness--a case study. (8882195)
1996
32
Relapses following treatment of early-stage Trypanosoma brucei gambiense sleeping sickness with a combination of pentamidine and suramin. (8761585)
1996
33
Sensitivity of animal-derived Trypanozoon stocks from sleeping sickness endemic foci of Nigeria to trypanocides and human plasma. (8552843)
1995
34
Risk factors assessment for T. b. rhodesiense sleeping sickness acquisition in S.E. Uganda. A case-control study. (7944647)
1994
35
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
36
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. (7932587)
1994
37
Diagnosis of Trypanosoma brucei gambiense sleeping sickness using an antigen detection enzyme-linked immunosorbent assay. (1566302)
1992
38
African sleeping sickness: an historical review. (1782243)
1991
39
A new method for isolating Trypanosoma brucei gambiense from sleeping sickness patients. (2617625)
1989
40
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
41
Death camps in the Congo: administrative responses to sleeping sickness 1903-1911. (11611572)
1984
42
Sleeping sickness in Iganga District, Uganda: application of a new diagnostic technique. (7318723)
1981
43
Palaeoecology of Tsetse flies and sleeping sickness in Africa. (11610781)
1980
44
Settlement and sleeping sickness control--a dual threshold model of colonial and traditional methods in East Africa. (524124)
1979
45
The penetrative ability of sleeping-sickness trypanosomes. (734725)
1978
46
Lymphocytic infiltration of the brain in sleeping sickness. (1087170)
1976
47
The complex epidemiology of Rhodesian sleeping sickness in Kenya and Uganda. I. The absence of the disease on Mfangano Island (Kenya). (4830620)
1974
48
Letter: Sleeping sickness. (4852929)
1974
49
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
50
New animal reservoirs of T. rhodesiense sleeping sickness. (4147877)
1973

Variations for Sleeping Sickness

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Expression for genes affiliated with Sleeping Sickness

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Expression patterns in normal tissues for genes affiliated with Sleeping Sickness

Search GEO for disease gene expression data for Sleeping Sickness.

Pathways for genes affiliated with Sleeping Sickness

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Pathways related to Sleeping Sickness according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL6, NOS2
29.9IL6, IL10
39.9IL6, IL10
4
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
9.7SRM, AMD1, ODC1
59.6NOS2, IL6, GFAP
69.6NOS2, IL6, IL10
79.6IL10, IL6, NOS2
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.6IL10, IL6, NOS2
9
Show member pathways
9.6IL10, IL6, NOS2
109.6IL10, IL6, NOS2
11
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.4ODC1, AMD1, SRM, NOS2
129.3NOS2, GAPDH, IL6
139.3GAPDH, IL6, IL10
14
Show member pathways
9.3MDH2, SRM, AMD1
159.2HPR, IL6, IL10, APOL1
16
Show member pathways
8.0ABCB7, ODC1, AMD1, SRM, GAPDH, NOS2

Compounds for genes affiliated with Sleeping Sickness

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Compounds related to Sleeping Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ethylglyoxal-bis-guanylhydrazone4410.4AMD1, ODC1
2abeado4410.4AMD1, ODC1
3methylglyoxal bis(guanylhydrazone)4410.4ODC1, AMD1
4sam 486a4410.3ODC1, AMD1
51-aminooxy-3-aminopropane4410.3SRM, ODC1
6S-Adenosylmethioninamine2410.3SRM, AMD1
7n(g)-hydroxy-l-arginine4410.3NOS2, ODC1
81,3-diaminopropane44 2411.2AMD1, ODC1
9cdp5714410.1IL6, IL10
10cadaverine44 2411.1AMD1, ODC1, SRM
11dfmo44 28 6112.1ODC1, AMD1, SRM
12putrescine44 28 24 1113.1SRM, ODC1, AMD1
13rebamipide4410.0IL6, NOS2
14spermidine44 28 24 1113.0SRM, ODC1, AMD1
152,5-oligoadenylate4410.0IL6, IL10, ODC1
16polyinosinic-polycytidylic acid449.9IL10, NOS2, IL6
17spermine28 44 24 1112.9ODC1, AMD1, SRM
18fluvastatin44 50 28 1112.9ABCB7, NOS2, IL6
19deet449.9NOS2, GAPDH, ODC1
20diisopropylfluorophosphate449.8ODC1, GAPDH, GFAP
21gsno449.8GAPDH, ODC1, NOS2
22taurine chloramine449.8IL6, GAPDH, NOS2
23citrulline44 2410.8NOS2, IL10, GAPDH
2415-deoxy-delta-12,14-prostaglandin j2449.8IL6, NOS2, IL10
25trypanothione44 1110.6SRM, ODC1
264-hydroxynonenal44 2410.5IL10, NOS2, ODC1, GAPDH
27peroxynitrite449.5GFAP, GAPDH, NOS2
28sb 20358044 6110.4NOS2, IL6, IL10, ODC1
29nmda44 2810.4GFAP, ODC1, AMD1, GAPDH, NOS2
30n acetylcysteine449.3ODC1, IL6, GAPDH, NOS2
31pge2449.2NOS2, GAPDH, ODC1, IL10, IL6
32glyceraldehyde 3-phosphate449.2MDH2, ODC1, GFAP, GAPDH
33methionine449.2ODC1, SRM, GFAP, HPR
34polyacrylamide449.1ABCB7, GFAP, GAPDH, MDH2
35ly294002449.0IL6, NOS2, GAPDH, IL10
36adenylate449.0NOS2, ODC1, GFAP, HPR, GAPDH
37ornithine44 2410.0MDH2, GAPDH, ODC1, SRM, AMD1
38creatinine448.9MDH2, IL6, GFAP, ABCB7, GAPDH
39testosterone44 61 24 1111.8ABCB7, ODC1, HPR, GAPDH, GFAP, IL6
40glutamine448.8GFAP, MDH2, ODC1, DNAJB1, GAPDH
41nitric oxide44 24 1110.8NOS2, GAPDH, IL10, ABCB7, ODC1, IL6
42cycloheximide448.8AMD1, GFAP, IL10, IL6, GAPDH, NOS2
43dexamethasone44 50 28 1111.7HPR, GFAP, IL10, IL6, NOS2
44aspartate448.7IL10, ODC1, GFAP, ABCB7, GAPDH, MDH2
45lactate448.7ABCB7, MDH2, GAPDH, ODC1, IL6, GFAP
46estrogen448.7GFAP, HPR, GAPDH, IL6, ODC1, NOS2
47glutamate448.7ODC1, ABCB7, GFAP, GAPDH, NOS2, MDH2
48glucose448.3GAPDH, GFAP, IL6, HPR, MDH2, ABCB7
49alanine448.3AMD1, ABCB7, GFAP, IL6, HPR, GAPDH
50atp44 289.3GFAP, DNAJB1, GAPDH, MDH2, HPR, ABCB7

GO Terms for genes affiliated with Sleeping Sickness

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Biological processes related to Sleeping Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermidine biosynthetic processGO:00829510.0SRM, AMD1
2polyamine metabolic processGO:0065959.8SRM, AMD1, ODC1
3cellular nitrogen compound metabolic processGO:0346419.7SRM, AMD1, ODC1
4defense response to Gram-negative bacteriumGO:0508299.6IL6, NOS2
5cellular response to interferon-gammaGO:0713469.6GAPDH, NOS2
6small molecule metabolic processGO:0442818.3ABCB7, ODC1, AMD1, SRM, GAPDH, MDH2

Products for genes affiliated with Sleeping Sickness

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  • Antibodies
  • Proteins
  • Lysates

Sources for Sleeping Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet