MCID: SLP001
MIFTS: 51

Sleeping Sickness malady

Infectious diseases category

Summaries for Sleeping Sickness

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8Disease Ontology, 3CDC, 43NINDS, 32MalaCards
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NINDS:43 Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma. Patients may also experience abnormal eye movements, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosis. The cause of encephalitis lethargica is unknown. Between 1917 to 1928, an epidemic of encephalitis lethargica spread throughout the world, but no recurrence of the epidemic has since been reported. Postencephalitic Parkinson's disease may develop after a bout of encephalitis-sometimes as long as a year after the illness.

MalaCards: Sleeping Sickness, also known as african trypanosomiasis, is related to leishmaniasis and trypanosomiasis. An important gene associated with Sleeping Sickness is APOL1 (apolipoprotein L, 1), and among its related pathways are Post-translational modification: synthesis of GPI-anchored proteins and Arginine and proline metabolism. The drugs eflornithine and eflornithine hydrochloride and the compounds abeado and ethylglyoxal-bis-guanylhydrazone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Disease Ontology:8 A trypanosomiasis that results from infection by trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (glossina spp). the symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.

CDC:3 African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly (Glossina species), which is found only in rural Africa. Although the infection is not found in the United States, historically, it has been a serious public health problem in some regions of sub-Saharan Africa. Currently, about 10,000 new cases each year are reported to the World Health organization; however, it is believed that many cases go undiagnosed and unreported. Sleeping sickness is curable with medication, but is fatal if left untreated.

Aliases & Classifications for Sleeping Sickness

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8Disease Ontology, 43NINDS, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
sleeping sickness:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

sleeping sickness 8 43 10 48
african trypanosomiasis 8 48 60
african sleeping sickness 8
trypanosomiasis african 44


External Ids:

Disease Ontology8 DOID:10112
MeSH34 D014353
ICD9CM27 086.5
NCIt39 C84541
MESH via Orphanet35 D014353
SNOMED-CT via Orphanet57 27031003
UMLS via Orphanet61 C0041228
ICD10 via Orphanet26 B56.0, B56.1, B56.9
ICD1025 B56

Related Diseases for Sleeping Sickness

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sleeping Sickness:



Diseases related to sleeping sickness

Clinical Features for Sleeping Sickness

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Drugs & Therapeutics for Sleeping Sickness

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sleeping Sickness

Drug clinical trials:

Search ClinicalTrials for Sleeping Sickness

Search NIH Clinical Center for Sleeping Sickness

Search CenterWatch for Sleeping Sickness

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sleeping Sickness

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Anatomical Context for Sleeping Sickness

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Sources:
32MalaCards
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MalaCards organs/tissues related to Sleeping Sickness:

32
Eye, Testes, Brain, Heart, Salivary gland, Testis, T cells, Pituitary

Animal Models for Sleeping Sickness or affiliated genes

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Publications for Sleeping Sickness

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50PubMed
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Articles related to Sleeping Sickness:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Drug Development Against Sleeping Sickness: Old Wine in New Bottles? (24251577)
2013
2
Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness. (22222041)
2012
3
Diversity of response to Trypanosoma brucei gambiense infections in the Forecariah mangrove focus (Guinea): perspectives for a better control of sleeping sickness. (21658462)
2011
4
Prevention and control of malaria and sleeping sickness in Africa: where are we and where are we going? (21410946)
2011
5
The development of drugs for treatment of sleeping sickness: a historical review. (20219092)
2010
6
Molecular diagnostics for sleeping sickness: what is the benefit for the patient? (20510283)
2010
7
A geographical approach to identify sleeping sickness risk factors in a mangrove ecosystem. (20545924)
2010
8
Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine MAcdecins Sans FrontiA"res programmes. (18947846)
2009
9
The continuing problem of human African trypanosomiasis (sleeping sickness). (18756506)
2008
10
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
11
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
12
Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness. (17205469)
2007
13
Molecular dipstick test for diagnosis of sleeping sickness. (16891507)
2006
14
A burgeoning epidemic of sleeping sickness in Uganda. (16125592)
2005
15
Quantifying the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness cases. (16135190)
2005
16
Sleeping sickness--a growing problem? (16308384)
2005
17
Sleep structure: a new diagnostic tool for stage determination in sleeping sickness. (15589803)
2005
18
Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in CA'te d'Ivoire: a new genetic group? (15228714)
2004
19
Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness. (14733670)
2003
20
Zentralblatt fA1r Bakteriologie--100 years ago: sleeping sickness--intoxication or infectious disease? (12398205)
2002
21
Sleeping sickness surveillance: an essential step towards elimination. (11348530)
2001
22
The duality of sleeping sickness: focusing on sleep. (12531051)
2001
23
Anti-sleeping sickness drugs and cancer chemotherapy. (10637579)
2000
24
Gambiense sleeping sickness: re-emerging and soon untreatable? (11143187)
2000
25
In vitro antitrypanosomal activity of African plants used in traditional medicine in Uganda to treat sleeping sickness. (8980587)
1996
26
Sleeping sickness: perspectives in African trypanosomiasis. (8973165)
1996
27
Risk factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma brucei gambiense sleeping sickness. (7747321)
1995
28
Multicentre evaluation of an antigen-detection ELISA for the diagnosis of Trypanosoma brucei rhodesiense sleeping sickness. (1568281)
1992
29
Detection of Trypanosoma brucei gambiense in the host and alternative sleeping sickness diagnostic approaches. (2679454)
1989
30
Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness. (2566790)
1989
31
A history of sleeping sickness in Kenya. (2694984)
1989
32
Eflornithine. A new drug in the treatment of sleeping sickness. (2505225)
1989
33
Presenting features of Rhodesian sleeping sickness patients in the Lambwe Valley, Kenya. (2619398)
1989
34
Workshop on Modelling Sleeping Sickness Epidemiology and Control. Antwerp, 25-29 January 1988. (2802814)
1989
35
Current knowledge on epidemiology and control of sleeping sickness. (2802823)
1989
36
Workshop on modelling sleeping sickness epidemiology. (15463061)
1988
37
Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial. (3938090)
1985
38
From "death camps" to cordon sanitaire: the development of sleeping sickness policy in the Uele district of the Belgian Congo, 1903-1914. (11617235)
1985
39
The experimental use of 'sentinel' goats to monitor trypanosomiasis in a Zambian sleeping sickness focus. Part I. The isolation of Trypanosoma brucei rhodesiense-like organisms from a 'sentinel' domestic goat. (6476933)
1984
40
Epidemiological studies on the animal reservoir of gambiense sleeping sickness. Part II. Parasitological and immunodiagnostic examination of the human population. (6285560)
1981
41
A tsetse survey of Luuka and Kigulu counties of South Busoga District, Uganda, during an outbreak of African sleeping sickness. (7296023)
1981
42
Field diagnosis of sleeping sickness in the Ivory Coast. I. Comparison of the miniature anion-exchange/centrifugation technique with other protozoological methods. (6272458)
1981
43
Palaeoecology of Tsetse flies and sleeping sickness in Africa. (11610781)
1980
44
African sleeping sickness today. (960197)
1976
45
Complement activation in patients with Gambian sleeping sickness. (949871)
1976
46
The diagnosis of sleeping sickness in a district hospital in Zambia. (1232957)
1975
47
Man against insect. 2. David Bruce v sleeping sickness. (4602923)
1974
48
Clinical Mel B, resistance in Rhodesian sleeping sickness. (4839238)
1974
49
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
50
The diagnosis of sleeping sickness. (4715059)
1973

Genetic Variations for Sleeping Sickness

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Expression for genes affiliated with Sleeping Sickness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleeping Sickness

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Pathways for genes affiliated with Sleeping Sickness

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Sleeping Sickness according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PIGB, PIGL
2
Hide members
10.0ODC1, AMD1, SRM
3
Hide members
10.0ODC1, AMD1, SRM
4
Glutathione metabolism
Hide members
10.0SRM, ODC1, PGD

Compounds for genes affiliated with Sleeping Sickness

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Sleeping Sickness according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1abeado4410.5ODC1, AMD1
2ethylglyoxal-bis-guanylhydrazone4410.5AMD1, ODC1
3methylglyoxal bis(guanylhydrazone)4410.5ODC1, AMD1
41-aminooxy-3-aminopropane4410.5SRM, ODC1
5sam 486a4410.5ODC1, AMD1
61,3-diaminopropane44 2411.4ODC1, AMD1
7cadaverine44 2411.3ODC1, AMD1, SRM
8trypanothione44 1111.3ODC1, SRM
9dfmo44 59 2812.3ODC1, AMD1, SRM
10hydrazine4410.3AMD1, ODC1
11putrescine44 28 11 2413.3SRM, AMD1, ODC1
12spermidine44 28 11 2413.3SRM, AMD1, ODC1
13spermine44 28 11 2413.2AMD1, SRM, ODC1
14carbon dioxide44 2411.2ODC1, AMD1, PGD
15s-adenosylmethionine44 11 2412.2AMD1, ODC1, SRM
16maltose44 1111.1ODC1, HPR
17ornithine44 2411.1MDH2, SRM, ODC1, AMD1
185-methylthioadenosine4410.0ODC1, SRM
19citrate4410.0PGD, ODC1, MDH2
20lactate449.8ABCB7, MDH2, ODC1, PGD
216-phosphogluconate449.8PGD, MDH2

GO Terms for genes affiliated with Sleeping Sickness

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16Gene Ontology
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Biological processes related to Sleeping Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermidine biosynthetic processGO:00829510.2AMD1, SRM
2C-terminal protein lipidationGO:00650110.1PIGL, PIGB
3polyamine metabolic processGO:00659510.1AMD1, SRM, ODC1
4preassembly of GPI anchor in ER membraneGO:01625410.0PIGB, PIGL
5GPI anchor biosynthetic processGO:0065069.8PIGL, PIGB

Products for genes affiliated with Sleeping Sickness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleeping Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet