MCID: SLP001
MIFTS: 51

Sleeping Sickness malady

Infectious diseases category

Summaries for Sleeping Sickness

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8Disease Ontology, 3CDC, 43NINDS, 32MalaCards
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NINDS:43 Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma. Patients may also experience abnormal eye movements, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosis. The cause of encephalitis lethargica is unknown. Between 1917 to 1928, an epidemic of encephalitis lethargica spread throughout the world, but no recurrence of the epidemic has since been reported. Postencephalitic Parkinson's disease may develop after a bout of encephalitis-sometimes as long as a year after the illness.

MalaCards: Sleeping Sickness, also known as african trypanosomiasis, is related to leishmaniasis and trypanosomiasis. An important gene associated with Sleeping Sickness is APOL1 (apolipoprotein L, 1), and among its related pathways are Post-translational modification: synthesis of GPI-anchored proteins and Arginine and proline metabolism. The drugs eflornithine and eflornithine hydrochloride and the compounds abeado and ethylglyoxal-bis-guanylhydrazone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Disease Ontology:8 A trypanosomiasis that results from infection by trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (glossina spp). the symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.

CDC:3 African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly (Glossina species), which is found only in rural Africa. Although the infection is not found in the United States, historically, it has been a serious public health problem in some regions of sub-Saharan Africa. Currently, about 10,000 new cases each year are reported to the World Health organization; however, it is believed that many cases go undiagnosed and unreported. Sleeping sickness is curable with medication, but is fatal if left untreated.

Aliases & Classifications for Sleeping Sickness

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8Disease Ontology, 43NINDS, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
sleeping sickness:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

sleeping sickness 8 43 10 48
african trypanosomiasis 8 48 60
african sleeping sickness 8
trypanosomiasis african 44


External Ids:

Disease Ontology8 DOID:10112
MeSH34 D014353
ICD9CM27 086.5
NCIt39 C84541
MESH via Orphanet35 D014353
SNOMED-CT via Orphanet57 27031003
UMLS via Orphanet61 C0041228
ICD10 via Orphanet26 B56.0, B56.1, B56.9
ICD1025 B56

Related Diseases for Sleeping Sickness

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sleeping Sickness:



Diseases related to sleeping sickness

Clinical Features for Sleeping Sickness

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Drugs & Therapeutics for Sleeping Sickness

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sleeping Sickness

Drug clinical trials:

Search ClinicalTrials for Sleeping Sickness

Search NIH Clinical Center for Sleeping Sickness

Search CenterWatch for Sleeping Sickness

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sleeping Sickness

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Anatomical Context for Sleeping Sickness

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Sources:
32MalaCards
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MalaCards organs/tissues related to Sleeping Sickness:

32
Eye, Testes, Brain, Heart, Salivary gland, Testis, T cells, Pituitary

Animal Models for Sleeping Sickness or affiliated genes

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Publications for Sleeping Sickness

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50PubMed
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Articles related to Sleeping Sickness:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness. (23469311)
2013
2
Gene fusion analysis in the battle against the African endemic sleeping sickness. (23874788)
2013
3
New WHO plan targets the demise of sleeping sickness. (23297428)
2013
4
Factors affecting the propensity of tsetse flies to enter houses and attack humans inside: increased risk of sleeping sickness in warmer climates. (23638209)
2013
5
Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post-conflict Uganda. (24289452)
2013
6
A neglected aspect of the epidemiology of sleeping sickness: the propensity of the tsetse fly vector to enter houses. (23469309)
2013
7
Towards an early warning system for Rhodesian sleeping sickness in savannah areas: man-like traps for tsetse flies. (23301107)
2012
8
Epidemiology of sleeping sickness in Boffa (Guinea): where are the trypanosomes? (23272259)
2012
9
A new transmission risk index for human African trypanosomiasis and its application in the identification of sites of high transmission of sleeping sickness in the Fontem focus of southwest Cameroon. (21198712)
2011
10
Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice. (21526217)
2011
11
Time to put out the lights on sleeping sickness? (20970729)
2010
12
Controlling sleeping sickness--"when will they ever learn?". (20520799)
2010
13
Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. (19916554)
2010
14
The interaction of an antiparasitic peptide active against African sleeping sickness with cell membrane models. (19729286)
2009
15
The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness. (19346560)
2009
16
NECT trial: more than a small victory over sleeping sickness. (19559477)
2009
17
Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study. (18321960)
2008
18
Public-private partnership works to stamp out sleeping sickness in Uganda. (17392023)
2007
19
Nifurtimox plus Eflornithine for late-stage sleeping sickness in Uganda: a case series. (18060083)
2007
20
Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go. (17990226)
2007
21
Human African trypanosomiasis (sleeping sickness): epidemiological update. (16673459)
2006
22
Mixed infections of trypanosomes in tsetse and pigs and their epidemiological significance in a sleeping sickness focus of CA'te d'Ivoire. (15648692)
2004
23
Paediatric sleeping sickness in Kenya: A case report. (17298120)
2004
24
Possible cases of sexual and congenital transmission of sleeping sickness. (14738812)
2004
25
The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness. (15217727)
2004
26
Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine. (14597107)
2003
27
Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei. (11983889)
2002
28
Face shift. How sleeping sickness parasites evade human defenses. (11951328)
2002
29
Homology modeling and molecular dynamics study of NAD-dependent glycerol-3-phosphate dehydrogenase from Trypanosoma brucei rhodesiense, a potential target enzyme for anti-sleeping sickness drug development. (12023213)
2002
30
African sleeping sickness returns to UK after four years. (11073504)
2000
31
Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness. (11005849)
2000
32
Resurgence of sleeping sickness in Tambura County, Sudan. (10463686)
1999
33
Production of sleeping-sickness treatment. (10489988)
1999
34
Human African trypanosomiasis (sleeping sickness). (10446530)
1999
35
Sensitivity of animal-derived Trypanozoon stocks from sleeping sickness endemic foci of Nigeria to trypanocides and human plasma. (8552843)
1995
36
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. (7932587)
1994
37
From trypanosomes to the nervous system, from molecules to behavior: a survey, on the occasion of the 90th anniversary of Castellani's discovery of the parasites in sleeping sickness. (8056556)
1994
38
Immunoassay of circulating trypanosomal antigens in sleeping sickness patients undergoing treatment. (8150987)
1994
39
Eflornithine concentrations in serum and cerebrospinal fluid of 63 patients treated for Trypanosoma brucei gambiense sleeping sickness. (8249087)
1993
40
The significance of human serum sensitivity in the context of T.B. rhodesiense sleeping sickness epidemiology and control. (1644047)
1992
41
Glossina fuscipes fuscipes and Glossina palpalis palpalis as joint vectors of sleeping sickness in the focus of Nola-Bilolo in the Central African Republic. (1354934)
1992
42
Can education of the community help sleeping sickness control: a study from Cameroon. (2219417)
1990
43
Sleeping sickness in the Lambwe Valley in 1978. (2694985)
1989
44
Serodiagnosis of sleeping sickness in the Republic of the Congo: comparison of indirect immunofluorescent antibody test and card agglutination test. (3055461)
1988
45
Tsetse ecology in a Liberian rain-forest focus of Gambian sleeping sickness. (2979539)
1987
46
Classics in cytology: note on fine needle aspiration of the lymphatic glands in sleeping sickness. (3461654)
1986
47
Characterization of potentially man-infective Trypanosoma brucei from an endemic area of sleeping sickness in Kenya. (4081544)
1985
48
Epidemiological studies on the animal reservoir of gambiense sleeping sickness. Part I. Review of literature and description of the study areas. (6285559)
1981
49
The complex epidemiology of Rhodesian sleeping sickness in Kenya and Uganda. II. Observations in Samia (Kenya). (4854688)
1974
50
An amastigote phase of the sleeping sickness trypanosome. (5157437)
1971

Genetic Variations for Sleeping Sickness

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Expression for genes affiliated with Sleeping Sickness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleeping Sickness

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Pathways for genes affiliated with Sleeping Sickness

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Sleeping Sickness according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PIGB, PIGL
2
Hide members
10.0ODC1, AMD1, SRM
3
Hide members
10.0SRM, AMD1, ODC1
4
Glutathione metabolism
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10.0ODC1, PGD, SRM

Compounds for genes affiliated with Sleeping Sickness

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Sleeping Sickness according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1abeado4410.5ODC1, AMD1
2ethylglyoxal-bis-guanylhydrazone4410.5ODC1, AMD1
3methylglyoxal bis(guanylhydrazone)4410.5AMD1, ODC1
41-aminooxy-3-aminopropane4410.5ODC1, SRM
5sam 486a4410.5ODC1, AMD1
61,3-diaminopropane44 2411.4AMD1, ODC1
7cadaverine44 2411.3SRM, AMD1, ODC1
8trypanothione44 1111.3SRM, ODC1
9dfmo44 59 2812.3ODC1, AMD1, SRM
10hydrazine4410.3AMD1, ODC1
11putrescine44 28 11 2413.3SRM, AMD1, ODC1
12spermidine44 28 11 2413.3SRM, AMD1, ODC1
13spermine44 28 11 2413.2ODC1, AMD1, SRM
14carbon dioxide44 2411.2ODC1, AMD1, PGD
15s-adenosylmethionine44 11 2412.2SRM, AMD1, ODC1
16maltose44 1111.1HPR, ODC1
17ornithine44 2411.1ODC1, AMD1, MDH2, SRM
185-methylthioadenosine4410.0SRM, ODC1
19citrate4410.0ODC1, MDH2, PGD
20lactate449.8ABCB7, PGD, MDH2, ODC1
216-phosphogluconate449.8MDH2, PGD

GO Terms for genes affiliated with Sleeping Sickness

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16Gene Ontology
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Biological processes related to Sleeping Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermidine biosynthetic processGO:00829510.2SRM, AMD1
2C-terminal protein lipidationGO:00650110.1PIGB, PIGL
3polyamine metabolic processGO:00659510.1SRM, AMD1, ODC1
4preassembly of GPI anchor in ER membraneGO:01625410.0PIGL, PIGB
5GPI anchor biosynthetic processGO:0065069.8PIGB, PIGL

Products for genes affiliated with Sleeping Sickness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleeping Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet