MCID: SLP001
MIFTS: 47

Sleeping Sickness malady

Infectious category

Summaries for Sleeping Sickness

Sources:
8Disease Ontology, 3CDC, 44NINDS, 33MalaCards
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NINDS:44 Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma. Patients may also experience abnormal eye movements, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosis. The cause of encephalitis lethargica is unknown. Between 1917 to 1928, an epidemic of encephalitis lethargica spread throughout the world, but no recurrence of the epidemic has since been reported. Postencephalitic Parkinson's disease may develop after a bout of encephalitis-sometimes as long as a year after the illness.

MalaCards: Sleeping Sickness, also known as african trypanosomiasis, is related to trypanosomiasis and chagas disease. An important gene associated with Sleeping Sickness is APOL1 (apolipoprotein L, 1), and among its related pathways are Post-translational modification: synthesis of GPI-anchored proteins and Arginine and proline metabolism. The drugs eflornithine and eflornithine hydrochloride and the compounds ethylglyoxal-bis-guanylhydrazone and abeado have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and heart.

Disease Ontology:8 A trypanosomiasis that results from infection by trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (glossina spp). the symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.

CDC:3 African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly (Glossina species), which is found only in rural Africa. Although the infection is not found in the United States, historically, it has been a serious public health problem in some regions of sub-Saharan Africa. Currently, about 10,000 new cases each year are reported to the World Health organization; however, it is believed that many cases go undiagnosed and unreported. Sleeping sickness is curable with medication, but is fatal if left untreated.

Aliases & Classifications for Sleeping Sickness

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 49Orphanet, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
sleeping sickness:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

sleeping sickness 8 44 10 49
african trypanosomiasis 8 49 61
african sleeping sickness 8
trypanosomiasis african 45


External Ids:

Disease Ontology8 DOID:10112
MeSH35 D014353
ICD9CM27 086.5
NCIt40 C84541
MESH via Orphanet36 D014353
ICD10 via Orphanet26 B56
SNOMED-CT via Orphanet58 27031003
UMLS via Orphanet62 C0041228
ICD1025 B56

Related Diseases for Sleeping Sickness

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Sleeping Sickness:



Diseases related to sleeping sickness

Clinical Features for Sleeping Sickness

Drugs & Therapeutics for Sleeping Sickness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Sleeping Sickness

Drug clinical trials:

Search ClinicalTrials for Sleeping Sickness

Search NIH Clinical Center for Sleeping Sickness

Search CenterWatch for Sleeping Sickness

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Sleeping Sickness

Anatomical Context for Sleeping Sickness

Sources:
33MalaCards
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MalaCards organs/tissues related to Sleeping Sickness:

33
Whole blood, Brain, Heart, Salivary gland, Testis, T cells, B cells, Pituitary

Animal Models for Sleeping Sickness or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sleeping Sickness

Sources:
51PubMed
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Articles related to Sleeping Sickness:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Closing in on a new treatment for sleeping sickness. (23853715)
2013
2
Elimination of sleeping sickness hindered by difficult diagnosis. (24115791)
2013
3
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
4
Treatment outcomes for human African Trypanosomiasis in the Democratic Republic of the Congo: analysis of routine program data from the world's largest sleeping sickness control program. (22809002)
2012
5
Apparent lack of a domestic animal reservoir in Gambiense sleeping sickness in northwest Uganda. (22245071)
2012
6
Genetic diversity and population structure of the secondary symbiont of tsetse flies, Sodalis glossinidius, in sleeping sickness foci in Cameroon. (21886849)
2011
7
Sleeping sickness pathogen (Trypanosoma brucei) and natural products: therapeutic targets and screening systems. (20945274)
2011
8
Experiences with an in-training community service model in the control of zoonotic sleeping sickness in Uganda. (20847337)
2010
9
Overproduction, purification and characterisation of Tbj1, a novel Type III Hsp40 from Trypanosoma brucei, the African sleeping sickness parasite. (19815073)
2010
10
Molecular diagnostics for sleeping sickness: what is the benefit for the patient? (20510283)
2010
11
A geographical approach to identify sleeping sickness risk factors in a mangrove ecosystem. (20545924)
2010
12
How to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness. (20047500)
2010
13
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo. (17990225)
2007
14
Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis). (18076548)
2007
15
Merial prize for sleeping sickness. (17570701)
2007
16
Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness. (17205469)
2007
17
Detection of trypanosome-specific antibodies in saliva, towards non-invasive serological diagnosis of sleeping sickness. (16640614)
2006
18
A burgeoning epidemic of sleeping sickness in Uganda. (16125592)
2005
19
Quantifying the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness cases. (16135190)
2005
20
Sleeping sickness--a growing problem? (16308384)
2005
21
Treatment of late stage sleeping sickness caused by T.b. gambiense: a new approach to the use of an old drug. (11971197)
2002
22
Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene. (11755607)
2001
23
Sleeping sickness in Sri Lanka. (11006622)
2000
24
Relapses following treatment of early-stage Trypanosoma brucei gambiense sleeping sickness with a combination of pentamidine and suramin. (8761585)
1996
25
Hypogonadism in Rhodesian sleeping sickness: evidence for acute and chronic dysfunction of the hypothalamic-pituitary-gonadal axis. (8557157)
1996
26
Night duty: sleeping sickness. (7703140)
1995
27
Epidemiological evidence for immunity following Trypanosoma brucei gambiense sleeping sickness. (8594669)
1995
28
Multicentre evaluation of an antigen-detection ELISA for the diagnosis of Trypanosoma brucei rhodesiense sleeping sickness. (1568281)
1992
29
Reactivation of an old sleeping sickness focus in Mamfe (Cameroon): epidemiological, immunological and parasitological findings. (2031097)
1991
30
An antigen detection enzyme immunoassay for the diagnosis of rhodesiense sleeping sickness. (2927956)
1989
31
A history of sleeping sickness in Kenya. (2694984)
1989
32
Eflornithine. A new drug in the treatment of sleeping sickness. (2505225)
1989
33
Workshop on modelling sleeping sickness epidemiology. (15463061)
1988
34
Use of procyclic trypanosomes for detection of antibodies in sera from vervet monkeys infected with Trypanosoma rhodesiense: an immunodiagnostic test for African sleeping sickness. (2882666)
1986
35
African sleeping sickness--African trypanosomiasis. The story of its conquest. (11611975)
1986
36
Field evaluation of Cellognost indirect haemagglutination test in the diagnosis of human trypanosomiasis (sleeping sickness) in Kura local government area of Kano State, Nigeria. (2862781)
1985
37
The public health significance of trypanosomiasis (sleeping sickness) in Nigeria. (4055267)
1985
38
Risk factors associated with the acquisition of sleeping sickness in north-east Zambia; a case-control study. (3865637)
1985
39
Suramin/metronidazole combination for African sleeping sickness. (2864521)
1985
40
Control of sleeping sickness due to Trypanosoma brucei gambiense. (6984372)
1982
41
Cryptic stage of sleeping-sickness trypanosome developing in choroid plexus epithelial cells. (6814567)
1982
42
African sleeping sickness: new evidence that mature tsetse flies (Glossina morsitans) can become potent vectors. (6926764)
1982
43
A tsetse survey of Luuka and Kigulu counties of South Busoga District, Uganda, during an outbreak of African sleeping sickness. (7296023)
1981
44
Field diagnosis of sleeping sickness in the Ivory Coast. I. Comparison of the miniature anion-exchange/centrifugation technique with other protozoological methods. (6272458)
1981
45
Settlement and sleeping sickness control--a dual threshold model of colonial and traditional methods in East Africa. (524124)
1979
46
African sleeping sickness today. (960197)
1976
47
Complement activation in patients with Gambian sleeping sickness. (949871)
1976
48
Viral encephalitis (sleeping sickness). (132425)
1976
49
New animal reservoirs of T. rhodesiense sleeping sickness. (4147877)
1973
50
Pregnancy complications in Rhodesian sleeping sickness. (4720443)
1973

Genetic Variations for Sleeping Sickness

Expression for genes affiliated with Sleeping Sickness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sleeping Sickness

Search GEO for disease gene expression data for Sleeping Sickness.

Pathways for genes affiliated with Sleeping Sickness

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Sleeping Sickness according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1PIGB, PIGL
2
Hide members
10.0ODC1, AMD1, SRM
3
Hide members
10.0ODC1, AMD1, SRM
4
Glutathione metabolism
Hide members
10.0SRM, ODC1, PGD

Compounds for genes affiliated with Sleeping Sickness

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Sleeping Sickness according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1ethylglyoxal-bis-guanylhydrazone4510.5AMD1, ODC1
2abeado4510.5AMD1, ODC1
3methylglyoxal bis(guanylhydrazone)4510.5ODC1, AMD1
41-aminooxy-3-aminopropane4510.5ODC1, SRM
5sam 486a4510.5ODC1, AMD1
61,3-diaminopropane45 2411.4AMD1, ODC1
7cadaverine45 2411.3SRM, ODC1, AMD1
8trypanothione45 1111.3SRM, ODC1
9dfmo45 60 2912.3ODC1, AMD1, SRM
10hydrazine4510.3ODC1, AMD1
11putrescine45 29 11 2413.3AMD1, ODC1, SRM
12spermidine45 29 11 2413.3SRM, ODC1, AMD1
13spermine45 29 11 2413.2AMD1, ODC1, SRM
14carbon dioxide45 2411.2ODC1, AMD1, PGD
15s-adenosylmethionine45 11 2412.2AMD1, ODC1, SRM
16maltose45 1111.1ODC1, HPR
17ornithine45 2411.1AMD1, SRM, ODC1, MDH2
185-methylthioadenosine4510.0SRM, ODC1
19citrate4510.0PGD, MDH2, ODC1
20lactate459.8ABCB7, PGD, MDH2, ODC1
216-phosphogluconate459.8MDH2, PGD

GO Terms for genes affiliated with Sleeping Sickness

Sources:
16Gene Ontology
See all sources

Biological processes related to Sleeping Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermidine biosynthetic processGO:00829510.2AMD1, SRM
2C-terminal protein lipidationGO:00650110.1PIGL, PIGB
3polyamine metabolic processGO:00659510.1AMD1, SRM, ODC1
4preassembly of GPI anchor in ER membraneGO:01625410.0PIGB, PIGL
5GPI anchor biosynthetic processGO:0065069.8PIGL, PIGB

Products for genes affiliated with Sleeping Sickness

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleeping Sickness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet