MCID: SLP001
MIFTS: 56

Sleeping Sickness malady

Infectious diseases, Rare diseases categories

Summaries for Sleeping Sickness

About this section
Sources:
9Disease Ontology, 4CDC, 45NINDS, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NINDS:45 Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma. Patients may also experience abnormal eye movements, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosis. The cause of encephalitis lethargica is unknown. Between 1917 to 1928, an epidemic of encephalitis lethargica spread throughout the world, but no recurrence of the epidemic has since been reported. Postencephalitic Parkinson's disease may develop after a bout of encephalitis-sometimes as long as a year after the illness.

MalaCards: Sleeping Sickness, also known as african trypanosomiasis, is related to leishmaniasis and chagas disease. An important gene associated with Sleeping Sickness is APOL1 (apolipoprotein L, 1), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Cytokine Network. The drugs eflornithine and eflornithine hydrochloride and the compounds abeado and ethylglyoxal-bis-guanylhydrazone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are liver/biliary system and mortality/aging.

Disease Ontology:9 A trypanosomiasis that results from infection by trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (glossina spp). the symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances.

CDC:4 African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei. It is transmitted by the tsetse fly (Glossina species), which is found only in rural Africa. Although the infection is not found in the United States, historically, it has been a serious public health problem in some regions of sub-Saharan Africa. Currently, about 10,000 new cases each year are reported to the World Health organization; however, it is believed that many cases go undiagnosed and unreported. Sleeping sickness is curable with medication, but is fatal if left untreated.

Aliases & Classifications for Sleeping Sickness

About this section
Sources:
9Disease Ontology, 45NINDS, 11DISEASES, 50Orphanet, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 27ICD10 via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

50
sleeping sickness:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

sleeping sickness 9 45 11 50
african trypanosomiasis 9 50 63
african sleeping sickness 9
trypanosomiasis african 46


External Ids:

Disease Ontology9 DOID:10112
MeSH36 D014353
NCIt41 C84541
ICD9CM28 086.5
MESH via Orphanet37 D014353
SNOMED-CT via Orphanet60 27031003
UMLS via Orphanet64 C0041228
ICD10 via Orphanet27 B56.0, B56.1, B56.9
ICD1026 B56

Related Diseases for Sleeping Sickness

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Sleeping Sickness via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1leishmaniasis30.7SRM, IL10, MDH2
2chagas disease30.6ODC1, AMD1, SRM, GAPDH
3malaria30.6ODC1, AMD1, SRM, IL10, HPR, GAPDH
4cerebral malaria30.1NOS2, IL10
5trypanosomiasis10.8
6choroiditis10.4
7cerebritis10.3
8amebiasis10.1
9orchitis10.1
10endomyocardial fibrosis10.1
11onchocerciasis10.1
12pseudobulbar palsy10.1
13filariasis10.1
14microsporidiosis10.1
15hiv-110.1
16endotheliitis10.1
17hepatitis c10.1
18narcolepsy10.1
19eastern equine encephalitis10.1
20viral encephalitis10.1
21visceral leishmaniasis10.1
22encephalitis10.1
23hepatitis10.1
24hypogonadism10.1
25trypanosomiasis, human east-african10.1
26trypanosomiasis, human west-african10.1
27hepatitis c virus10.1
28adrenocortical insufficiency10.1
29myoepithelioma10.0GFAP, NOS2
30primary hyperoxaluria10.0HPR, IL6, APOL1
31thrombocytopenia10.0ABCB7, IL6, HPR
32galactosemia10.0IL10, IL6, HPR
33pleomorphic adenoma10.0GFAP, NOS2
34type 1 diabetes mellitus10.0NOS2, IL10
35prion disease10.0NOS2, ODC1, GFAP
36acute pancreatitis10.0IL6, IL10, ABCB7
37plasmodium falciparum malaria10.0IL10, NOS2
38congenital heart disease10.0HPR, IL6, IL10
39meningioma10.0GAPDH, ODC1, GFAP
40adult respiratory distress syndrome10.0IL6, NOS2
41deficiency anemia9.9ABCB7, IL6, HPR, GAPDH
42ulcerative colitis9.9NOS2, IL6, IL10
43arthritis9.9IL10, IL6, HPR, NOS2
44tuberculosis9.9IL10, HPR, GAPDH, MDH2
45multiple sclerosis9.9GFAP, IL10, IL6, NOS2
46glioblastoma multiforme9.9GFAP, ODC1, GAPDH, NOS2
47astrocytoma9.9GFAP, IL6, GAPDH, NOS2
48septic shock9.9IL10, IL6, GAPDH, NOS2
49pre-eclampsia9.9IL10, IL6, GAPDH, NOS2
50sepsis9.9IL10, IL6, GAPDH, NOS2

Graphical network of the top 20 diseases related to Sleeping Sickness:



Diseases related to sleeping sickness

Symptoms for Sleeping Sickness

About this section

Drugs & Therapeutics for Sleeping Sickness

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sleeping Sickness

Drug clinical trials:

Search ClinicalTrials for Sleeping Sickness

Search NIH Clinical Center for Sleeping Sickness

Search CenterWatch for Sleeping Sickness

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Sleeping Sickness

About this section

Anatomical Context for Sleeping Sickness

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Sleeping Sickness:

34
Eye, Testes, Brain, Heart, T cells, Salivary gland, Testis, Pituitary

Animal Models for Sleeping Sickness or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Sleeping Sickness:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8NOS2, GAPDH, IL6, IL10, ABCB7
2MP:00107687.6NOS2, ABCB7, GFAP, ODC1, AMD1, IL10

Publications for Sleeping Sickness

About this section
Sources:
53PubMed
See all sources

Articles related to Sleeping Sickness:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Closing in on a new treatment for sleeping sickness. (23853715)
2013
2
Conflict of interest: use of pyrethroids and amidines against tsetse and ticks in zoonotic sleeping sickness endemic areas of Uganda. (23841963)
2013
3
Secreted proteases of Trypanosoma brucei gambiense: possible targets for sleeping sickness control? (23553721)
2013
4
Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness. (23469311)
2013
5
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. (23145187)
2012
6
The chemistry and biology of trypanosomal trans-sialidases: virulence factors in Chagas disease and sleeping sickness. (21956798)
2011
7
Clinical presentation of T.b. rhodesiense sleeping sickness in second stage patients from Tanzania and Uganda. (21407802)
2011
8
Tsetse elimination: its interest and feasibility in the historical sleeping sickness focus of Loos islands, Guinea. (19353949)
2009
9
The interaction of an antiparasitic peptide active against African sleeping sickness with cell membrane models. (19729286)
2009
10
The natural progression of Gambiense sleeping sickness: what is the evidence? (19104656)
2008
11
Sleeping glands? - The role of endocrine disorders in sleeping sickness (T.b. gambiense Human African Trypanosomiasis). (17767911)
2007
12
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis. (17610127)
2007
13
Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness. (17331943)
2007
14
Public-private partnership works to stamp out sleeping sickness in Uganda. (17392023)
2007
15
Using remote sensing and geographic information systems to identify villages at high risk for rhodesiense sleeping sickness in Uganda. (16246384)
2006
16
Capacity of community-based organisations to disseminate sleeping sickness information. (16261917)
2005
17
Retaking sleeping sickness control in Angola. (14728618)
2004
18
Mixed infections of trypanosomes in tsetse and pigs and their epidemiological significance in a sleeping sickness focus of CA'te d'Ivoire. (15648692)
2004
19
Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in CA'te d'Ivoire: a new genetic group? (15228714)
2004
20
Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness. (14733670)
2003
21
Researches on the etiology of sleeping sickness. 1903. (15272468)
2003
22
The challenge of Trypanosoma brucei gambiense sleeping sickness diagnosis outside Africa. (14652206)
2003
23
Characterization of Trypanosoma brucei s.l. subspecies by isoenzymes in domestic pigs from the Fontem sleeping sickness focus of Cameroon. (11835899)
2002
24
IgM quantification in the cerebrospinal fluid of sleeping sickness patients by a latex card agglutination test. (12167095)
2002
25
African sleeping sickness in tourists returning from Tanzania: the first 2 Italian cases from a small outbreak among European travelers. (11731969)
2002
26
Sleeping sickness resurgence in the DRC: the past decade. (11348528)
2001
27
African sleeping sickness returns to UK after four years. (11073504)
2000
28
Sleeping sickness in Sri Lanka. (11006622)
2000
29
Isolation of Trypanosoma brucei from the monitor lizard (Varanus niloticus) in an endemic focus of Rhodesian sleeping sickness in Kenya. (10206114)
1999
30
Duration of symptoms and case fatality of sleeping sickness caused by Trypanosoma brucei rhodesiense in Tororo, Uganda. (9557424)
1997
31
Metronidazole and suramin combination in the treatment of arsenical refractory Rhodesian sleeping sickness--a case study. (8882195)
1996
32
Relapses following treatment of early-stage Trypanosoma brucei gambiense sleeping sickness with a combination of pentamidine and suramin. (8761585)
1996
33
Sensitivity of animal-derived Trypanozoon stocks from sleeping sickness endemic foci of Nigeria to trypanocides and human plasma. (8552843)
1995
34
Risk factors assessment for T. b. rhodesiense sleeping sickness acquisition in S.E. Uganda. A case-control study. (7944647)
1994
35
An evaluation of the reactivity of the card agglutination test for trypanosomiasis (CATT) reagent in the Fontem sleeping sickness focus, Cameroon. (7839945)
1994
36
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. (7932587)
1994
37
Diagnosis of Trypanosoma brucei gambiense sleeping sickness using an antigen detection enzyme-linked immunosorbent assay. (1566302)
1992
38
African sleeping sickness: an historical review. (1782243)
1991
39
A new method for isolating Trypanosoma brucei gambiense from sleeping sickness patients. (2617625)
1989
40
Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. (3703156)
1986
41
Death camps in the Congo: administrative responses to sleeping sickness 1903-1911. (11611572)
1984
42
Sleeping sickness in Iganga District, Uganda: application of a new diagnostic technique. (7318723)
1981
43
Palaeoecology of Tsetse flies and sleeping sickness in Africa. (11610781)
1980
44
Settlement and sleeping sickness control--a dual threshold model of colonial and traditional methods in East Africa. (524124)
1979
45
The penetrative ability of sleeping-sickness trypanosomes. (734725)
1978
46
Lymphocytic infiltration of the brain in sleeping sickness. (1087170)
1976
47
The complex epidemiology of Rhodesian sleeping sickness in Kenya and Uganda. I. The absence of the disease on Mfangano Island (Kenya). (4830620)
1974
48
Letter: Sleeping sickness. (4852929)
1974
49
The function of the choroid plexus in the brain of rabbits infected with the sleeping sickness trypanosome. (4712297)
1973
50
New animal reservoirs of T. rhodesiense sleeping sickness. (4147877)
1973

Variations for Sleeping Sickness

About this section

Expression for genes affiliated with Sleeping Sickness

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sleeping Sickness

Search GEO for disease gene expression data for Sleeping Sickness.

Pathways for genes affiliated with Sleeping Sickness

About this section
Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 39NCBI BioSystems Database, 56Reactome, 31KEGG
See all sources

Pathways related to Sleeping Sickness according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL6, NOS2
29.9IL6, IL10
39.9IL6, IL10
4
Show member pathways
creatine-phosphate biosynthesis39
glycine degradation (creatine biosynthesis)39
putrescine biosynthesis III39
spermidine biosynthesis I39
tryptophan degradation via kynurenine39
spermine biosynthesis39
urea cycle39
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I39
tyrosine degradation I39
L-carnitine biosynthesis39
methylthiopropionate biosynthesis39
2-oxoglutarate decarboxylation to succinyl-CoA39
S-methyl-5-thioadenosine degradation II39
9.7SRM, AMD1, ODC1
59.6NOS2, IL6, GFAP
69.6NOS2, IL6, IL10
79.6IL10, IL6, NOS2
8
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.6IL10, IL6, NOS2
9
Show member pathways
9.6IL10, IL6, NOS2
109.6IL10, IL6, NOS2
11
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
9.4ODC1, AMD1, SRM, NOS2
129.3NOS2, GAPDH, IL6
139.3GAPDH, IL6, IL10
14
Show member pathways
9.3MDH2, SRM, AMD1
159.2HPR, IL6, IL10, APOL1
16
Show member pathways
8.0ABCB7, ODC1, AMD1, SRM, GAPDH, NOS2

Compounds for genes affiliated with Sleeping Sickness

About this section
Sources:
46Novoseek, 25HMDB, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 52PharmGKB
See all sources

Compounds related to Sleeping Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1abeado4610.4ODC1, AMD1
2ethylglyoxal-bis-guanylhydrazone4610.4ODC1, AMD1
3methylglyoxal bis(guanylhydrazone)4610.4AMD1, ODC1
4sam 486a4610.3AMD1, ODC1
51-aminooxy-3-aminopropane4610.3ODC1, SRM
6S-Adenosylmethioninamine2510.3SRM, AMD1
7n(g)-hydroxy-l-arginine4610.3NOS2, ODC1
81,3-diaminopropane46 2511.2ODC1, AMD1
9cdp5714610.1IL10, IL6
10cadaverine46 2511.1ODC1, AMD1, SRM
11dfmo46 30 6212.1SRM, AMD1, ODC1
12putrescine46 30 25 1213.1SRM, AMD1, ODC1
13rebamipide4610.0IL6, NOS2
14spermidine46 30 25 1213.0ODC1, AMD1, SRM
152,5-oligoadenylate4610.0ODC1, IL10, IL6
16spermine30 46 25 1212.9ODC1, AMD1, SRM
17polyinosinic-polycytidylic acid469.9IL10, IL6, NOS2
18fluvastatin46 52 30 1212.9NOS2, IL6, ABCB7
19deet469.9NOS2, GAPDH, ODC1
20diisopropylfluorophosphate469.8GFAP, ODC1, GAPDH
21gsno469.8ODC1, GAPDH, NOS2
22taurine chloramine469.8NOS2, GAPDH, IL6
23citrulline46 2510.8IL10, GAPDH, NOS2
2415-deoxy-delta-12,14-prostaglandin j2469.8NOS2, IL6, IL10
25trypanothione46 1210.6SRM, ODC1
264-hydroxynonenal46 2510.5ODC1, IL10, GAPDH, NOS2
27peroxynitrite469.5NOS2, GAPDH, GFAP
28sb 20358046 6210.4ODC1, IL10, IL6, NOS2
29nmda46 3010.4GFAP, ODC1, AMD1, GAPDH, NOS2
30n acetylcysteine469.3ODC1, IL6, GAPDH, NOS2
31pge2469.2ODC1, IL10, IL6, GAPDH, NOS2
32glyceraldehyde 3-phosphate469.2GFAP, ODC1, GAPDH, MDH2
33methionine469.2GFAP, ODC1, SRM, HPR
34polyacrylamide469.1ABCB7, GFAP, GAPDH, MDH2
35ly294002469.0NOS2, GAPDH, IL6, IL10
36adenylate469.0GFAP, ODC1, HPR, GAPDH, NOS2
37ornithine46 2510.0MDH2, GAPDH, SRM, AMD1, ODC1
38creatinine468.9ABCB7, GFAP, IL6, GAPDH, MDH2
39testosterone46 62 25 1211.8ABCB7, GFAP, ODC1, IL6, HPR, GAPDH
40glutamine468.8GFAP, ODC1, DNAJB1, GAPDH, MDH2
41nitric oxide46 25 1210.8ABCB7, ODC1, AMD1, IL10, IL6, GAPDH
42cycloheximide468.8GFAP, ODC1, AMD1, IL10, IL6, GAPDH
43dexamethasone46 52 30 1211.7GFAP, IL10, IL6, HPR, NOS2
44aspartate468.7ABCB7, GFAP, ODC1, IL10, GAPDH, MDH2
45lactate468.7ABCB7, GFAP, ODC1, IL6, GAPDH, MDH2
46estrogen468.7GFAP, ODC1, IL6, HPR, GAPDH, NOS2
47glutamate468.7MDH2, NOS2, GAPDH, ODC1, GFAP, ABCB7
48glucose468.3MDH2, GAPDH, HPR, IL6, GFAP, ABCB7
49alanine468.3ABCB7, GFAP, AMD1, IL6, HPR, GAPDH
50atp46 309.3ABCB7, GFAP, HPR, DNAJB1, GAPDH, MDH2

GO Terms for genes affiliated with Sleeping Sickness

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Sleeping Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermidine biosynthetic processGO:00829510.0SRM, AMD1
2polyamine metabolic processGO:0065959.8SRM, AMD1, ODC1
3cellular nitrogen compound metabolic processGO:0346419.7SRM, AMD1, ODC1
4defense response to Gram-negative bacteriumGO:0508299.6IL6, NOS2
5cellular response to interferon-gammaGO:0713469.6GAPDH, NOS2
6small molecule metabolic processGO:0442818.3ABCB7, ODC1, AMD1, SRM, GAPDH, MDH2

Products for genes affiliated with Sleeping Sickness

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sleeping Sickness

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet