MCID: SLP010
MIFTS: 34

Slipped Capital Femoral Epiphysis malady

Categories: Rare diseases

Aliases & Classifications for Slipped Capital Femoral Epiphysis

Aliases & Descriptions for Slipped Capital Femoral Epiphysis:

Name: Slipped Capital Femoral Epiphysis 50
Slipped Capital Femoral Epiphyses 69

Characteristics:

HPO:

32
slipped capital femoral epiphysis:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Slipped Capital Femoral Epiphysis

MalaCards based summary : Slipped Capital Femoral Epiphysis, also known as slipped capital femoral epiphyses, is related to epiphyseal chondrodysplasia, miura type and legg-calve-perthes disease, and has symptoms including proximal femoral epiphysiolysis and hip osteoarthritis. An important gene associated with Slipped Capital Femoral Epiphysis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Development IGF-1 receptor signaling and DNA Damage Response. The drugs Methyclothiazide and diuretics have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotype is muscle.

Wikipedia : 71 Slipped capital femoral epiphysis (SCFE or skiffy, slipped upper femoral epiphysis, SUFE or souffy, coxa... more...

Related Diseases for Slipped Capital Femoral Epiphysis

Diseases related to Slipped Capital Femoral Epiphysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 epiphyseal chondrodysplasia, miura type 11.3
2 legg-calve-perthes disease 11.3
3 osteonecrosis 10.5
4 obesity 10.5
5 hypothyroidism 10.5
6 hyperparathyroidism 10.4
7 osteoarthritis 10.3
8 osteopetrosis 10.3
9 gigantism 10.3
10 renal osteodystrophy 10.3
11 down syndrome 10.3
12 avascular necrosis of the femoral head 10.3
13 arthritis 10.3
14 pseudohypoparathyroidism 10.2
15 precocious puberty 10.2
16 turner syndrome 10.2
17 rubinstein-taybi syndrome 10.2
18 cerebral palsy 10.1
19 pituitary hypoplasia 10.1
20 septic arthritis 10.1
21 intracranial hypertension 10.1
22 congenital hypothyroidism 10.1
23 sickle cell disease 10.1
24 scoliosis 10.1
25 nephrocalcinosis 10.1
26 growth hormone deficiency 10.1
27 parathyroid carcinoma 10.1
28 central precocious puberty 10.1
29 headache 10.1
30 pituitary tumors 10.1
31 blount's disease 10.1
32 cerebritis 10.1
33 prader-willi syndrome 10.1
34 craniopharyngioma 10.1
35 tuberculosis 10.1
36 short stature with nonspecific skeletal abnormalities 10.0 IGF1 NPR2
37 seow najjar syndrome 10.0 IGF1 IGFBP3
38 microtia, hearing impairment, and cleft palate 9.9 IGF1 IGFBP3
39 spondylometaphyseal dysplasia, megarbane-dagher-melike type 9.9 IGF1 IGFBP3
40 capgras syndrome 9.9 IGF1 IGFBP3
41 diarrhea 3, secretory sodium, congenital, syndromic 9.9 IGF1 IGFBP3
42 pituitary adenoma, acth-secreting 9.9 IGF1 IGFBP3
43 epileptic encephalopathy, early infantile, 24 9.9 IGF1 IGFBP3
44 hyperinsulinemic hypoglycemia, familial, 5 9.9 IGF1 IGFBP3
45 protein s deficiency 9.9 IGF1 IGFBP3
46 phacolytic glaucoma 9.9 IGF1 IGFBP3
47 fetal warfarin syndrome 9.9 IGF1 IGFBP3
48 mental retardation, autosomal recessive 35 9.9 IGF1 IGFBP3
49 gerstmann syndrome 9.9 IGF1 IGFBP3
50 gynandroblastoma 9.9 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Slipped Capital Femoral Epiphysis:



Diseases related to Slipped Capital Femoral Epiphysis

Symptoms & Phenotypes for Slipped Capital Femoral Epiphysis

Human phenotypes related to Slipped Capital Femoral Epiphysis:

32
id Description HPO Frequency HPO Source Accession
1 proximal femoral epiphysiolysis 32 HP:0006461
2 hip osteoarthritis 32 HP:0008843

MGI Mouse Phenotypes related to Slipped Capital Femoral Epiphysis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 IGF1 IGFBP3 NPR2

Drugs & Therapeutics for Slipped Capital Femoral Epiphysis

Drugs for Slipped Capital Femoral Epiphysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyclothiazide Approved Phase 4 135-07-9 4121
2 diuretics Phase 4
3 Natriuretic Agents Phase 4
4 Sodium Chloride Symporter Inhibitors Phase 4
5 Gentamicins Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8
Pamidronate Approved 40391-99-9 4674
9 Diphosphonates
10 Bone Density Conservation Agents

Interventional clinical trials:

(show all 15)
id Name Status NCT ID Phase
1 A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Unknown status NCT00208442 Phase 4
2 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
3 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
4 A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
5 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
6 A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
7 A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
8 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
9 A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
10 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
11 A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
12 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
13 A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
14 Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis Unknown status NCT01220882
15 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Completed NCT02007915

Search NIH Clinical Center for Slipped Capital Femoral Epiphysis

Genetic Tests for Slipped Capital Femoral Epiphysis

Anatomical Context for Slipped Capital Femoral Epiphysis

MalaCards organs/tissues related to Slipped Capital Femoral Epiphysis:

39
Bone, Testes, Pituitary, Eye

Publications for Slipped Capital Femoral Epiphysis

Articles related to Slipped Capital Femoral Epiphysis:

(show top 50) (show all 584)
id Title Authors Year
1
Opinion survey of members of British Society of Children's Orthopaedic Surgery related to specific case scenarios in slipped capital femoral epiphysis. ( 28079739 )
2017
2
Instability of the hip after anatomical re-alignment in patients with a slipped capital femoral epiphysis. ( 28053252 )
2017
3
Hypothyroidism with Slipped Capital Femoral Epiphysis. ( 27053178 )
2016
4
Restoration of Blood Flow to the Proximal Femoral Epiphysis in Unstable Slipped Capital Femoral Epiphysis by Modified Dunn Procedure: A Preliminary Angiographic and Intracranial Pressure Monitoring Study. ( 27177236 )
2016
5
Association between body mass index-for-age and slipped capital femoral epiphysis: the long-term risk for subsequent slip in patients followed until physeal closure. ( 27095178 )
2016
6
Slipped capital femoral epiphysis and associated hypothyroidism. A review of the literature with two classic case examples. ( 26812778 )
2016
7
Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis?A A multicenter study. ( 27629912 )
2016
8
Intraoperative Monitoring of Epiphyseal Perfusion in Slipped Capital Femoral Epiphysis. ( 27307364 )
2016
9
Is Assessment of Femoral Head Perfusion During Modified Dunn for Unstable Slipped Capital Femoral Epiphysis an Accurate Indicator of Osteonecrosis? ( 27090261 )
2016
10
Subcapital Shortening Osteotomy for Severe Slipped Capital Femoral Epiphysis: Preliminary Results of the French Multicenter Study. ( 27603189 )
2016
11
CORR Insights(Ar): Iatrogenic Hip Instability Is a Devastating Complication After the Modified Dunn Procedure for Severe Slipped Capital Femoral Epiphysis. ( 27796803 )
2016
12
Outcome of the unaffected contralateral hip in unilateral slipped capital femoral epiphysis: a report comparing prophylactic fixation with observation. ( 27258363 )
2016
13
Surgical treatment of femoroacetabular impingement using controlled hip dislocation after occurrence of slipped capital femoral epiphysis. ( 27517020 )
2016
14
Comment on 'Closed reduction of slipped capital femoral epiphysis: high-risk factor for avascular necrosis'. ( 26583786 )
2016
15
Arthroscopic osteochondroplasty in patients with mild slipped capital femoral epiphysis after in situ fixation. ( 26586587 )
2016
16
Slipped Capital Femoral Epiphysis and Primary Hyperparathyroidism: A Case Report. ( 27920593 )
2016
17
Continued growth after fixation of slipped capital femoral epiphysis. ( 27817118 )
2016
18
Arthroscopic treatment of femoroacetabular impingement following slipped capital femoral epiphysis. ( 26733511 )
2016
19
Significantly lower femoral neck growth in screw fixation of the asymptomatic contralateral hip in unilateral slipped capital femoral epiphysis. ( 26919622 )
2016
20
Continuing Delay in the Diagnosis of Slipped Capital Femoral Epiphysis. ( 27470686 )
2016
21
Long-term outcomes of slipped capital femoral epiphysis treated with in situ pinning. ( 27438268 )
2016
22
The modified Dunn procedure for slipped capital femoral epiphysis does not reduce the length of the femoral neck. ( 27182244 )
2016
23
Fibular Allograft and Demineralized Bone Matrix for the Treatment of Slipped Capital Femoral Epiphysis. ( 27135447 )
2016
24
Continued Growth of the Femoral Neck Leads to Improved Remodeling After In Situ Fixation of Slipped Capital Femoral Epiphysis. ( 27261961 )
2016
25
Somatic HRPT2 Mutation (Arg234X) of Parathyroid Carcinoma Associated with Slipped Capital Femoral Epiphysis: A First Case Report. ( 27266237 )
2016
26
Slipped capital femoral epiphysis in adults: case report and review of literature. ( 27339373 )
2016
27
Transtrochanteric rotational osteotomy for avascular necrosis of the femoral head after unstable slipped capital femoral epiphysis: 10-year clinical results. ( 27461924 )
2016
28
Iatrogenic Hip Instability Is a Devastating Complication After the Modified Dunn Procedure for Severe Slipped Capital Femoral Epiphysis. ( 27650993 )
2016
29
The anatomical reduction of a moderate or severe stable slipped capital femoral epiphysis by modified Dunn subcapital osteotomy using the Ganz approach: functional and radiological outcomes. ( 27587533 )
2016
30
Slipped Capital Femoral Epiphysis in Atypical Patients. ( 27064469 )
2016
31
Treatment for unstable slipped capital femoral epiphysis: Current status and future challenge in Japan. ( 27613151 )
2016
32
The alpha angle as a predictor of contralateral slipped capital femoral epiphysis. ( 27052742 )
2016
33
Microarray analysis of slipped capital femoral epiphysis growth plates. ( 27390878 )
2016
34
Early MRI Detection and Closed Bone Graft Epiphysiodesis May Alter the Course of Avascular Necrosis Following Unstable Slipped Capital Femoral Epiphysis. ( 27261970 )
2016
35
CORR Insights(Ar): Is Assessment of Femoral Head Perfusion During Modified Dunn for Unstable Slipped Capital Femoral Epiphysis an Accurate Indicator of Osteonecrosis? ( 27146656 )
2016
36
Controversies in management of slipped capital femoral epiphysis. ( 26925378 )
2016
37
Levels of Evidence in the Treatment of Slipped Capital Femoral Epiphysis: A Systematic Review. ( 27433299 )
2016
38
Complications Related to the Treatment of Slipped Capital Femoral Epiphysis. ( 26772949 )
2016
39
Prophylactic pinning for slipped capital femoral epiphysis: does it affect proximal femoral morphology? ( 26588834 )
2016
40
Late correction of neck deformity in healed severe slipped capital femoral epiphysis: short-term clinical outcomes. ( 27229167 )
2016
41
Capital Femoral Epiphyseal Extension May Confer Physeal Stability in Slipped Capital Femoral Epiphysis. ( 27662386 )
2016
42
Slipped capital femoral epiphysis: long-term outcome and remodelling after in situ fixation. ( 26391266 )
2015
43
Slipped capital femoral epiphysis. ( 26501579 )
2015
44
A Case of Slipped Capital Femoral Epiphysis in Association With Craniopharyngioma. ( 26543843 )
2015
45
Current Practice in the Management of Slipped Capital Femoral Epiphysis. ( 25929770 )
2015
46
Severe slipped capital femoral epiphysis: A French multicenter study of 186 cases performed by the SoFOP. ( 26215089 )
2015
47
Letter to the Editor Regarding: "Two Cases of Avascular Necrosis After Prophylactic Pinning of the Asymptomatic, Contralateral Femoral Head for Slipped Capital Femoral Epiphysis: Case Report and Review of the Literature". ( 26214331 )
2015
48
Intracapsular Pressures After Stable Slipped Capital Femoral Epiphysis. ( 25812147 )
2015
49
Validity and Clinical Consequences of a Rotational Mechanism for Slipped Capital Femoral Epiphysis. ( 25812143 )
2015
50
Twelve percent of hips with a primary cam deformity exhibit a slip-like morphology resembling sequelae of slipped capital femoral epiphysis. ( 25448326 )
2015

Variations for Slipped Capital Femoral Epiphysis

Expression for Slipped Capital Femoral Epiphysis

Search GEO for disease gene expression data for Slipped Capital Femoral Epiphysis.

Pathways for Slipped Capital Femoral Epiphysis

GO Terms for Slipped Capital Femoral Epiphysis

Cellular components related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.16 IGF1 IGFBP3
2 positive regulation of MAPK cascade GO:0043410 8.96 IGF1 IGFBP3
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 IGFBP3

Sources for Slipped Capital Femoral Epiphysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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