MCID: SLP010
MIFTS: 33

Slipped Capital Femoral Epiphysis

Categories: Rare diseases

Aliases & Classifications for Slipped Capital Femoral Epiphysis

MalaCards integrated aliases for Slipped Capital Femoral Epiphysis:

Name: Slipped Capital Femoral Epiphysis 50
Slipped Capital Femoral Epiphyses 69

Classifications:



Summaries for Slipped Capital Femoral Epiphysis

MalaCards based summary : Slipped Capital Femoral Epiphysis, also known as slipped capital femoral epiphyses, is related to epiphyseal chondrodysplasia, miura type and epiphysiolysis of the hip. An important gene associated with Slipped Capital Femoral Epiphysis is NPR2 (Natriuretic Peptide Receptor 2), and among its related pathways/superpathways are Development IGF-1 receptor signaling and DNA Damage Response. The drugs Methyclothiazide and diuretics have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 72 Slipped capital femoral epiphysis (SCFE or skiffy, slipped upper femoral epiphysis, SUFE or souffy, coxa... more...

Related Diseases for Slipped Capital Femoral Epiphysis

Diseases related to Slipped Capital Femoral Epiphysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 epiphyseal chondrodysplasia, miura type 31.6 IGF1 NPR2
2 epiphysiolysis of the hip 11.4
3 legg-calve-perthes disease 11.3
4 osteonecrosis 10.5
5 hypothyroidism 10.5
6 obesity 10.5
7 hyperparathyroidism 10.4
8 avascular necrosis of the femoral head 10.3
9 down syndrome 10.3
10 arthritis 10.3
11 osteoarthritis 10.3
12 osteopetrosis 10.3
13 renal osteodystrophy 10.3
14 gigantism 10.3
15 turner syndrome 10.2
16 pseudohypoparathyroidism 10.2
17 precocious puberty 10.2
18 parathyroid carcinoma 10.1
19 prader-willi syndrome 10.1
20 cerebral palsy 10.1
21 congenital hypothyroidism 10.1
22 scoliosis 10.1
23 nephrocalcinosis 10.1
24 blount's disease 10.1
25 cerebritis 10.1
26 craniopharyngioma 10.1
27 tuberculosis 10.1
28 pituitary hypoplasia 10.1
29 septic arthritis 10.1
30 intracranial hypertension 10.1
31 sickle cell disease 10.1
32 growth hormone deficiency 10.1
33 central precocious puberty 10.1
34 headache 10.1
35 pituitary tumors 10.1
36 seizure disorder 10.1
37 selenium poisoning 9.9 IGF1 IGFBP3
38 lipase deficiency, combined 9.9 IGF1 IGFBP3
39 pulmonary large cell neuroendocrine carcinoma 9.9 IGF1 IGFBP3
40 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 9.9 IGF1 IGFBP3
41 hyperlipoproteinemia, type ib 9.9 IGF1 IGFBP3
42 protein s deficiency 9.9 IGF1 IGFBP3
43 growth hormone insensitivity, partial 9.9 IGF1 IGFBP3
44 pituitary adenoma, prolactin-secreting 9.9 IGF1 IGFBP3
45 glomerulosclerosis, focal segmental, 1 9.9 IGF1 IGFBP3
46 phacolytic glaucoma 9.8 IGF1 IGFBP3
47 fetal parvovirus syndrome 9.8 IGF1 IGFBP3
48 pericardial tuberculosis 9.8 IGF1 IGFBP3
49 caffey disease 9.8 IGF1 IGFBP3
50 grubben de cock borghgraef syndrome 9.8 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Slipped Capital Femoral Epiphysis:



Diseases related to Slipped Capital Femoral Epiphysis

Symptoms & Phenotypes for Slipped Capital Femoral Epiphysis

MGI Mouse Phenotypes related to Slipped Capital Femoral Epiphysis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.16 IGF1 NPR2
2 muscle MP:0005369 9.13 IGF1 IGFBP3 NPR2
3 respiratory system MP:0005388 8.62 IGF1 NPR2

Drugs & Therapeutics for Slipped Capital Femoral Epiphysis

Drugs for Slipped Capital Femoral Epiphysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyclothiazide Approved Phase 4 135-07-9 4121
2 diuretics Phase 4
3 Natriuretic Agents Phase 4
4 Sodium Chloride Symporter Inhibitors Phase 4
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Gentamicins Phase 4
8
Pamidronate Approved 40391-99-9 4674
9 Bone Density Conservation Agents
10 Diphosphonates

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Completed NCT00208442 Phase 4
2 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
3 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
4 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
5 A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
6 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
7 A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
8 A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
9 A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
10 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
11 A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
12 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
13 A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
14 Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis Unknown status NCT01220882
15 Slipped Capital Femoral Epiphysis Treatment Not yet recruiting NCT03229590
16 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Terminated NCT02007915 Pamidronate Disodium

Search NIH Clinical Center for Slipped Capital Femoral Epiphysis

Genetic Tests for Slipped Capital Femoral Epiphysis

Anatomical Context for Slipped Capital Femoral Epiphysis

MalaCards organs/tissues related to Slipped Capital Femoral Epiphysis:

39
Bone, Testes, Pituitary, Eye

Publications for Slipped Capital Femoral Epiphysis

Articles related to Slipped Capital Femoral Epiphysis:

(show top 50) (show all 604)
id Title Authors Year
1
Patient-specific 3D models aid planning for triplane proximal femoral osteotomy in slipped capital femoral epiphysis. ( 28529664 )
2017
2
Asynchronous slipped capital femoral epiphysis in a patient with a seizure disorder: case report and review of the literature. ( 28657919 )
2017
3
Surgical treatment of femoroacetabular impingement following slipped capital femoral epiphysis: A systematic review. ( 28790036 )
2017
4
Treatment of stable slipped capital femoral epiphysis: systematic review and exploratory patient level analysis. ( 28831651 )
2017
5
A nationwide cohort study of slipped capital femoral epiphysis. ( 28663349 )
2017
6
Arthroscopic Subcapital Realignment in Chronic and Stable Slipped Capital Femoral Epiphysis. ( 28706815 )
2017
7
Acetabular Retroversion, but Not Increased Acetabular Depth or Coverage, in Slipped Capital Femoral Epiphysis: A Matched-Cohort Study. ( 28632591 )
2017
8
Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. ( 28529660 )
2017
9
Prognostic factors for long-term outcome of chronic slipped capital femoral epiphysis treated with fixation in situ. ( 28529659 )
2017
10
The modified Dunn procedure for slipped capital femoral epiphysis: the Bernese experience. ( 28529663 )
2017
11
Slipped Capital Femoral Epiphysis: Diagnosis and Management. ( 28671425 )
2017
12
Residual Femoral Deformity and Femoroacetabular Impingement after Intertrochanteric Osteotomy for Slipped Capital Femoral Epiphysis. ( 28824187 )
2017
13
Instability of the hip after anatomical re-alignment in patients with a slipped capital femoral epiphysis. ( 28053252 )
2017
14
Slipped capital femoral epiphysis: a spectrum of surgical care and changes over time. ( 28529665 )
2017
15
Slipped capital femoral epiphysis in children younger than 10 years old: clinical characteristics and efficacy of physeal-sparing procedures. ( 28704299 )
2017
16
Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review. ( 28923047 )
2017
17
Slipped capital femoral epiphysis: a population-based study. ( 28720145 )
2017
18
Magnetic resonance imaging at primary diagnosis cannot predict subsequent contralateral slip in slipped capital femoral epiphysis. ( 28785827 )
2017
19
Slipped capital femoral epiphysis management and the arthroscope. ( 28529661 )
2017
20
Opinion survey of members of British Society of Children's Orthopaedic Surgery related to specific case scenarios in slipped capital femoral epiphysis. ( 28079739 )
2017
21
Treatment of chronic, stable slipped capital femoral epiphysis via surgical hip dislocation with combined osteochondroplasty and Imhauser osteotomy. ( 28904634 )
2017
22
Femoral and acetabular re-alignment in slipped capital femoral epiphysis. ( 28529662 )
2017
23
Prophylactic pinning for slipped capital femoral epiphysis: does it affect proximal femoral morphology? ( 26588834 )
2016
24
Restoration of Blood Flow to the Proximal Femoral Epiphysis in Unstable Slipped Capital Femoral Epiphysis by Modified Dunn Procedure: A Preliminary Angiographic and Intracranial Pressure Monitoring Study. ( 27177236 )
2016
25
Long-term outcomes of slipped capital femoral epiphysis treated with in situ pinning. ( 27438268 )
2016
26
Late correction of neck deformity in healed severe slipped capital femoral epiphysis: short-term clinical outcomes. ( 27229167 )
2016
27
Association between body mass index-for-age and slipped capital femoral epiphysis: the long-term risk for subsequent slip in patients followed until physeal closure. ( 27095178 )
2016
28
Intraoperative Monitoring of Epiphyseal Perfusion in Slipped Capital Femoral Epiphysis. ( 27307364 )
2016
29
Subcapital Shortening Osteotomy for Severe Slipped Capital Femoral Epiphysis: Preliminary Results of the French Multicenter Study. ( 27603189 )
2016
30
Slipped capital femoral epiphysis in adults: case report and review of literature. ( 27339373 )
2016
31
Arthroscopic treatment of femoroacetabular impingement following slipped capital femoral epiphysis. ( 26733511 )
2016
32
Transtrochanteric rotational osteotomy for avascular necrosis of the femoral head after unstable slipped capital femoral epiphysis: 10-year clinical results. ( 27461924 )
2016
33
Arthroscopic osteochondroplasty in patients with mild slipped capital femoral epiphysis after in situ fixation. ( 26586587 )
2016
34
Microarray analysis of slipped capital femoral epiphysis growth plates. ( 27390878 )
2016
35
Fibular Allograft and Demineralized Bone Matrix for the Treatment of Slipped Capital Femoral Epiphysis. ( 27135447 )
2016
36
Continued Growth of the Femoral Neck Leads to Improved Remodeling After In Situ Fixation of Slipped Capital Femoral Epiphysis. ( 27261961 )
2016
37
Controversies in management of slipped capital femoral epiphysis. ( 26925378 )
2016
38
Slipped capital femoral epiphysis and associated hypothyroidism. A review of the literature with two classic case examples. ( 26812778 )
2016
39
Continuing Delay in the Diagnosis of Slipped Capital Femoral Epiphysis. ( 27470686 )
2016
40
Outcome of the unaffected contralateral hip in unilateral slipped capital femoral epiphysis: a report comparing prophylactic fixation with observation. ( 27258363 )
2016
41
The alpha angle as a predictor of contralateral slipped capital femoral epiphysis. ( 27052742 )
2016
42
Comment on 'Closed reduction of slipped capital femoral epiphysis: high-risk factor for avascular necrosis'. ( 26583786 )
2016
43
The anatomical reduction of a moderate or severe stable slipped capital femoral epiphysis by modified Dunn subcapital osteotomy using the Ganz approach: functional and radiological outcomes. ( 27587533 )
2016
44
Complications Related to the Treatment of Slipped Capital Femoral Epiphysis. ( 26772949 )
2016
45
Significantly lower femoral neck growth in screw fixation of the asymptomatic contralateral hip in unilateral slipped capital femoral epiphysis. ( 26919622 )
2016
46
CORR Insights(Ar): Is Assessment of Femoral Head Perfusion During Modified Dunn for Unstable Slipped Capital Femoral Epiphysis an Accurate Indicator of Osteonecrosis? ( 27146656 )
2016
47
Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis?A A multicenter study. ( 27629912 )
2016
48
Continued growth after fixation of slipped capital femoral epiphysis. ( 27817118 )
2016
49
Hypothyroidism with Slipped Capital Femoral Epiphysis. ( 27053178 )
2016
50
Somatic HRPT2 Mutation (Arg234X) of Parathyroid Carcinoma Associated with Slipped Capital Femoral Epiphysis: A First Case Report. ( 27266237 )
2016

Variations for Slipped Capital Femoral Epiphysis

Expression for Slipped Capital Femoral Epiphysis

Search GEO for disease gene expression data for Slipped Capital Femoral Epiphysis.

Pathways for Slipped Capital Femoral Epiphysis

GO Terms for Slipped Capital Femoral Epiphysis

Cellular components related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.16 IGF1 IGFBP3
2 positive regulation of MAPK cascade GO:0043410 8.96 IGF1 IGFBP3
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 IGFBP3

Sources for Slipped Capital Femoral Epiphysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....