MCID: SLP010
MIFTS: 37

Slipped Capital Femoral Epiphysis

Categories: Rare diseases

Aliases & Classifications for Slipped Capital Femoral Epiphysis

MalaCards integrated aliases for Slipped Capital Femoral Epiphysis:

Name: Slipped Capital Femoral Epiphysis 49
Slipped Capital Femoral Epiphyses 69

Classifications:



External Ids:

UMLS 69 C0149887

Summaries for Slipped Capital Femoral Epiphysis

MalaCards based summary : Slipped Capital Femoral Epiphysis, also known as slipped capital femoral epiphyses, is related to turner syndrome and growth hormone deficiency. An important gene associated with Slipped Capital Femoral Epiphysis is NPR2 (Natriuretic Peptide Receptor 2), and among its related pathways/superpathways are Development IGF-1 receptor signaling and DNA Damage Response. The drugs Methyclothiazide and diuretics have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotypes are limbs/digits/tail and muscle

Related Diseases for Slipped Capital Femoral Epiphysis

Diseases related to Slipped Capital Femoral Epiphysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 turner syndrome 30.1 IGF1 IGFBP3
2 growth hormone deficiency 29.9 IGF1 IGFBP3
3 prader-willi syndrome 29.5 IGF1 IGFBP3
4 epiphysiolysis of the hip 12.1
5 legg-calve-perthes disease 11.5
6 epiphyseal chondrodysplasia, miura type 11.5
7 osteonecrosis 10.6
8 hypothyroidism 10.6
9 body mass index quantitative trait locus 8 10.6
10 body mass index quantitative trait locus 7 10.6
11 body mass index quantitative trait locus 12 10.6
12 body mass index quantitative trait locus 14 10.6
13 episodic pain syndrome, familial, 1 10.6
14 body mass index quantitative trait locus 11 10.6
15 body mass index quantitative trait locus 18 10.6
16 aging 10.6
17 body mass index quantitative trait locus 9 10.6
18 body mass index quantitative trait locus 1 10.5
19 hyperparathyroidism 10.5
20 osteoarthritis with mild chondrodysplasia 10.5
21 osteoarthritis 10.5
22 body mass index quantitative trait locus 4 10.4
23 body mass index quantitative trait locus 10 10.4
24 primary hyperparathyroidism 10.4
25 arthritis 10.4
26 cataract 5, multiple types 10.4
27 osteopetrosis 10.4
28 gigantism 10.4
29 avascular necrosis of femoral head, primary, 1 10.4
30 renal osteodystrophy 10.4
31 down syndrome 10.4
32 pseudohypoparathyroidism 10.3
33 precocious puberty 10.3
34 chromosome 16p13.3 deletion syndrome, proximal 10.3
35 pituitary hormone deficiency, combined, 2 10.3
36 cerebral palsy 10.1
37 pituitary hypoplasia 10.1
38 septic arthritis 10.1
39 blood group, i system 10.1
40 intracranial hypertension 10.1
41 sickle cell disease 10.1
42 coxa vara 10.1
43 mycobacterium tuberculosis 1 10.1
44 congenital hypothyroidism 10.1
45 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 10.1
46 hypercalciuria, absorptive, 2 10.1
47 parathyroid carcinoma 10.1
48 scoliosis 10.1
49 hypercalcemia, infantile, 1 10.1
50 nephrocalcinosis 10.1

Graphical network of the top 20 diseases related to Slipped Capital Femoral Epiphysis:



Diseases related to Slipped Capital Femoral Epiphysis

Symptoms & Phenotypes for Slipped Capital Femoral Epiphysis

MGI Mouse Phenotypes related to Slipped Capital Femoral Epiphysis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 IGF1 IGFBP3 NPR2
2 muscle MP:0005369 9.13 IGF1 IGFBP3 NPR2
3 respiratory system MP:0005388 8.8 IGF1 IGFBP3 NPR2

Drugs & Therapeutics for Slipped Capital Femoral Epiphysis

Drugs for Slipped Capital Femoral Epiphysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyclothiazide Approved Phase 4 135-07-9 4121
2 diuretics Phase 4
3 Sodium Chloride Symporter Inhibitors Phase 4
4 Natriuretic Agents Phase 4
5 Gentamicins Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8
Pamidronate Approved 40391-99-9 4674
9 Diphosphonates
10 Bone Density Conservation Agents

Interventional clinical trials:

(show all 17)

# Name Status NCT ID Phase Drugs
1 A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement Completed NCT00872066 Phase 4
2 A Randomised Single Centre Study to Compare the Long-term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip Replacement Completed NCT00208442 Phase 4
3 A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing Terminated NCT00873444 Phase 4
4 A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00872794 Phase 4
5 A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement Terminated NCT00872573 Phase 4
6 Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip Replacement Terminated NCT00872547 Phase 4
7 A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement Terminated NCT00872222 Phase 4
8 A Multi-centre Study to Assess the Long-term Performance of the Summit™ Hip in Primary Total Hip Replacement Terminated NCT00208390 Phase 4
9 A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery Terminated NCT00208377 Phase 4
10 A Two Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Metal-on-Metal Bearing in Primary Total Hip Replacement Terminated NCT00208364 Phase 4
11 A Multi-centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Polyethylene-on-metal Bearing in Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
12 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
13 A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
14 Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis Unknown status NCT01220882
15 "Gait and Balance in Patients With SCFE" Recruiting NCT03326531
16 Slipped Capital Femoral Epiphysis Treatment Not yet recruiting NCT03229590
17 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Terminated NCT02007915 Pamidronate Disodium

Search NIH Clinical Center for Slipped Capital Femoral Epiphysis

Genetic Tests for Slipped Capital Femoral Epiphysis

Anatomical Context for Slipped Capital Femoral Epiphysis

MalaCards organs/tissues related to Slipped Capital Femoral Epiphysis:

38
Bone, Testes, Pituitary, Eye

Publications for Slipped Capital Femoral Epiphysis

Articles related to Slipped Capital Femoral Epiphysis:

(show top 50) (show all 618)
# Title Authors Year
1
Comparison between modified Dunn procedure and in situ fixation for severe stable slipped capital femoral epiphysis. ( 29451057 )
2018
2
Surgical treatment of femoroacetabular impingement after slipped capital femoral epiphysis. ( 29206650 )
2018
3
Valgus Slipped Capital Femoral Epiphysis: Pathophysiology of Motion and Results of Intracapsular Realignment. ( 29373445 )
2018
4
Persisting CAM deformity is associated with early cartilage degeneration after Slipped Capital Femoral Epiphysis: 11-year follow-up including dGEMRIC. ( 29426010 )
2018
5
Femoral pseudoaneurysm as a complication of slipped capital femoral epiphysis treatment. ( 29367918 )
2018
6
Diagnosis and treatment of slipped capital femoral epiphysis: Recent trends to note. ( 29361376 )
2018
7
Magnetic resonance imaging at primary diagnosis cannot predict subsequent contralateral slip in slipped capital femoral epiphysis. ( 28785827 )
2017
8
Prognostic factors for long-term outcome of chronic slipped capital femoral epiphysis treated with fixation in situ. ( 28529659 )
2017
9
Acetabular Retroversion, but Not Increased Acetabular Depth or Coverage, in Slipped Capital Femoral Epiphysis: A Matched-Cohort Study. ( 28632591 )
2017
10
Asynchronous slipped capital femoral epiphysis in a patient with a seizure disorder: case report and review of the literature. ( 28657919 )
2017
11
3-dimensional metrics of proximal femoral shape deformities in Legg-CalvAc-Perthes disease and slipped capital femoral epiphysis. ( 29087625 )
2017
12
Seasonal Variation in Slipped Capital Femoral Epiphysis: New Findings Using a National Children's Hospital Database. ( 28961634 )
2017
13
Slipped capital femoral epiphysis management and the arthroscope. ( 28529661 )
2017
14
Fixation in slipped capital femoral epiphysis avoiding femoral-acetabular impingement. ( 29084548 )
2017
15
Femoral head fracture similar to slipped capital femoral epiphysis in an elderly woman with antecedent hip osteoarthritis after subchondral insufficiency fracture: A case report. ( 28967534 )
2017
16
Treatment of chronic, stable slipped capital femoral epiphysis via surgical hip dislocation with combined osteochondroplasty and Imhauser osteotomy. ( 28904634 )
2017
17
Femoral and acetabular re-alignment in slipped capital femoral epiphysis. ( 28529662 )
2017
18
Slipped Capital Femoral Epiphysis: Diagnosis and Management. ( 28671425 )
2017
19
Slipped capital femoral epiphysis: a spectrum of surgical care and changes over time. ( 28529665 )
2017
20
Biomechanical considerations in slipped capital femoral epiphysis and insights into prophylactic fixation. ( 28529660 )
2017
21
Slipped capital femoral epiphysis in children younger than 10 years old: clinical characteristics and efficacy of physeal-sparing procedures. ( 28704299 )
2017
22
The modified Dunn procedure for slipped capital femoral epiphysis: the Bernese experience. ( 28529663 )
2017
23
A nationwide cohort study of slipped capital femoral epiphysis. ( 28663349 )
2017
24
Instability of the hip after anatomical re-alignment in patients with a slipped capital femoral epiphysis. ( 28053252 )
2017
25
Slipped capital femoral epiphysis: a population-based study. ( 28720145 )
2017
26
Good inter- and intraobserver reliability for assessment of the slip angle in 77 hip radiographs of children with a slipped capital femoral epiphysis. ( 29212388 )
2017
27
Opinion survey of members of British Society of Children's Orthopaedic Surgery related to specific case scenarios in slipped capital femoral epiphysis. ( 28079739 )
2017
28
Arthroscopic Subcapital Realignment in Chronic and Stable Slipped Capital Femoral Epiphysis. ( 28706815 )
2017
29
A comparison study of radiographic and computerized tomographic angles in slipped capital femoral epiphysis. ( 29062815 )
2017
30
Patient-specific 3D models aid planning for triplane proximal femoral osteotomy in slipped capital femoral epiphysis. ( 28529664 )
2017
31
Treatment of stable slipped capital femoral epiphysis: systematic review and exploratory patient level analysis. ( 28831651 )
2017
32
Residual Femoral Deformity and Femoroacetabular Impingement after Intertrochanteric Osteotomy for Slipped Capital Femoral Epiphysis. ( 28824187 )
2017
33
Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review. ( 28923047 )
2017
34
Outcome of pinning in patients with slipped capital femoral epiphysis: risk factors associated with avascular necrosis, chondrolysis, and femoral impingement. ( 29210310 )
2017
35
Early osteoarthritis after slipped capital femoral epiphysis. ( 29172934 )
2017
36
Surgical treatment of femoroacetabular impingement following slipped capital femoral epiphysis: A systematic review. ( 28790036 )
2017
37
Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis?A A multicenter study. ( 27629912 )
2016
38
Capital Femoral Epiphyseal Extension May Confer Physeal Stability in Slipped Capital Femoral Epiphysis. ( 27662386 )
2016
39
Restoration of Blood Flow to the Proximal Femoral Epiphysis in Unstable Slipped Capital Femoral Epiphysis by Modified Dunn Procedure: A Preliminary Angiographic and Intracranial Pressure Monitoring Study. ( 27177236 )
2016
40
Significantly lower femoral neck growth in screw fixation of the asymptomatic contralateral hip in unilateral slipped capital femoral epiphysis. ( 26919622 )
2016
41
Is Assessment of Femoral Head Perfusion During Modified Dunn for Unstable Slipped Capital Femoral Epiphysis an Accurate Indicator of Osteonecrosis? ( 27090261 )
2016
42
Association between body mass index-for-age and slipped capital femoral epiphysis: the long-term risk for subsequent slip in patients followed until physeal closure. ( 27095178 )
2016
43
CORR Insights(Ar): Iatrogenic Hip Instability Is a Devastating Complication After the Modified Dunn Procedure for Severe Slipped Capital Femoral Epiphysis. ( 27796803 )
2016
44
Intraoperative Monitoring of Epiphyseal Perfusion in Slipped Capital Femoral Epiphysis. ( 27307364 )
2016
45
Iatrogenic Hip Instability Is a Devastating Complication After the Modified Dunn Procedure for Severe Slipped Capital Femoral Epiphysis. ( 27650993 )
2016
46
Long-term outcomes of slipped capital femoral epiphysis treated with in situ pinning. ( 27438268 )
2016
47
Fibular Allograft and Demineralized Bone Matrix for the Treatment of Slipped Capital Femoral Epiphysis. ( 27135447 )
2016
48
Arthroscopic treatment of femoroacetabular impingement following slipped capital femoral epiphysis. ( 26733511 )
2016
49
Complications Related to the Treatment of Slipped Capital Femoral Epiphysis. ( 26772949 )
2016
50
Controversies in management of slipped capital femoral epiphysis. ( 26925378 )
2016

Variations for Slipped Capital Femoral Epiphysis

Expression for Slipped Capital Femoral Epiphysis

Search GEO for disease gene expression data for Slipped Capital Femoral Epiphysis.

Pathways for Slipped Capital Femoral Epiphysis

GO Terms for Slipped Capital Femoral Epiphysis

Cellular components related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Slipped Capital Femoral Epiphysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.16 IGF1 IGFBP3
2 positive regulation of MAPK cascade GO:0043410 8.96 IGF1 IGFBP3
3 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 IGFBP3

Sources for Slipped Capital Femoral Epiphysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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