MCID: SML032
MIFTS: 31

Small Bowel Adenocarcinoma malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Small Bowel Adenocarcinoma

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32MalaCards
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MalaCards: Small Bowel Adenocarcinoma, also known as adenocarcinoma of small intestine, is related to adenocarcinoma and colorectal cancer. An important gene associated with Small Bowel Adenocarcinoma is PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid)), and among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Linoleic acid metabolism. The compounds prostaglandin and ly311727 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Small Bowel Adenocarcinoma

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Sources:
48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

small bowel adenocarcinoma 48
adenocarcinoma of small intestine 60


External Ids:

SNOMED-CT via Orphanet57 424440001
ICD10 via Orphanet26 D01.4

Related Diseases for Small Bowel Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Small Bowel Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.6MLH1, PLA2G4A, PLA2G2A, PTGS2
2colorectal cancer30.7PTGS2, PLA2G4A, MLH1
3crohn's disease10.8
4neurofibromatosis10.4
5peritonitis10.3
6celiac disease10.2
7small intestine adenocarcinoma10.2
8mature teratoma10.1
9deficiency anemia10.1
10dermatofibrosarcoma10.1
11intussusception10.1
12iron deficiency anemia10.1
13peutz-jeghers syndrome10.1
14anal canal adenocarcinoma10.1
15gastric adenocarcinoma10.1
16hemolytic anemia10.1
17intestinal disease10.1
18liver disease10.1
19ovary adenocarcinoma10.1
20synovitis10.0PLA2G2A
21pancreatitis10.0PLA2G2A
22biliary tract neoplasm10.0MLH1
23gallbladder cancer10.0MLH1
24rhinitis10.0PLA2G2A
25myeloid leukemia10.0CSF3
26keratoacanthoma10.0MLH1
27cystic fibrosis10.0PLA2G4A
28encephalomyelitis10.0PLA2G4A
29endometrial carcinoma10.0MLH1
30obesity10.0PLA2G4A
31cervical squamous cell carcinoma10.0MLH1
32oral cancer10.0PTGS2
33vascular disease10.0PTGS2
34melanoma10.0PLA2G2A, MLH1
35endometriosis10.0PTGS2
36ischemia10.0PLA2G2A, PLA2G4A
37asthma10.0PLA2G4A, PLA2G2A
38psoriasis10.0PLA2G2A
39septic shock10.0PLA2G2A, CSF3
40hepatocellular carcinoma10.0PTGS2
41schizophrenia10.0PLA2G2A, PLA2G4A
42prion disease10.0PLA2G4A, PLA2G2A
43cholangiocarcinoma10.0PTGS2, PLA2G4A
44colon adenocarcinoma10.0PTGS2, MLH1
45osteoarthritis10.0PLA2G2A, PTGS2
46astrocytoma10.0MLH1, PLA2G4A, PLA2G2A
47transitional cell carcinoma10.0PTGS2, MLH1
48pancreatic cancer10.0PTGS2, PLA2G2A, MLH1
49inflammatory bowel disease10.0PTGS2, PLA2G2A, MLH1
50adenoma10.0MLH1, PLA2G2A, PTGS2

Graphical network of the top 20 diseases related to Small Bowel Adenocarcinoma:



Diseases related to small bowel adenocarcinoma

Clinical Features for Small Bowel Adenocarcinoma

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Drugs & Therapeutics for Small Bowel Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Small Bowel Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Small Bowel Adenocarcinoma

Search NIH Clinical Center for Small Bowel Adenocarcinoma

Search CenterWatch for Small Bowel Adenocarcinoma

Genetic Tests for Small Bowel Adenocarcinoma

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Anatomical Context for Small Bowel Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Small Bowel Adenocarcinoma:

32
Small intestine

Animal Models for Small Bowel Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Small Bowel Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1PTGS2, PLA2G2A, PLA2G4A, MLH1

Publications for Small Bowel Adenocarcinoma

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Genetic Variations for Small Bowel Adenocarcinoma

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Expression for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Bowel Adenocarcinoma

Search GEO for disease gene expression data for Small Bowel Adenocarcinoma.

Pathways for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PLA2G4A, PLA2G2A
2
Hide members
9.4PLA2G2A, PLA2G4A
3
Anandamide biosynthesis and metabolism
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9.4PLA2G2A, PLA2G4A
4
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9.4PLA2G2A, PLA2G4A
59.2PTGS2, PLA2G2A
69.0PTGS2, PLA2G4A
79.0PLA2G4A, PTGS2
89.0PTGS2, PLA2G4A
9
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9.0PTGS2, PLA2G4A
10
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8.9CSF3, PLA2G4A, PLA2G2A
11
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8.6PLA2G2A, PTGS2, PLA2G4A
128.6PLA2G2A, PTGS2, PLA2G4A
13
Hide members
8.6PLA2G4A, PTGS2, PLA2G2A
14
Hide members
8.6PLA2G4A, PLA2G2A, PTGS2
15
Hide members
8.6PLA2G4A, PLA2G2A, PTGS2
16
Hide members
8.1PTGS2, PLA2G2A, PLA2G4A, CSF3

Compounds for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1prostaglandin4410.2PLA2G4A
2ly311727449.8PLA2G2A, PLA2G4A
3scalaradial449.8PLA2G4A, PLA2G2A
412-hpete449.8PLA2G2A, PLA2G4A
5manoalide449.8PLA2G2A, PLA2G4A
6p-bromophenacyl bromide449.8PLA2G2A, PLA2G4A
7bromoenol lactone449.8PLA2G4A, PLA2G2A
8melittin449.8PLA2G2A, PLA2G4A
9dacarbazine44 1110.8CSF3, MLH1
10lysophospholipid449.8PLA2G2A, PLA2G4A
11aristolochic acid44 210.7PLA2G2A, PLA2G4A
12staurosporin449.7PLA2G2A, PLA2G4A
13platinum44 4910.7MLH1, CSF3
14alpha-linolenic acid44 11 2411.7PLA2G2A, PLA2G4A
15quinacrine44 1110.6PLA2G2A, PLA2G4A
16dexamethasone44 49 28 1112.6PTGS2, PLA2G2A
17m-3m3fbs599.6PLA2G4A, PLA2G2A
18u 73343599.5PLA2G4A, PLA2G2A
19fipi599.5PLA2G4A, PLA2G2A
20lenalidomide44 1110.5PTGS2, CSF3
21d609599.5PLA2G4A, PLA2G2A
22Aldesleukin119.4PTGS2, PLA2G4A
23lysophosphatidylcholine44 2810.4PLA2G4A, PLA2G2A
24niflumic acid44 28 1111.4PTGS2, PLA2G4A
25flurbiprofen44 28 49 1112.3PLA2G4A, PTGS2
26(+-)-pgf2-alpha449.3PLA2G4A, PTGS2
27fmlp449.3CSF3, PLA2G4A, PLA2G2A
28glycerol44 11 2411.2MLH1, PLA2G4A, PLA2G2A
29irinotecan44 49 1111.0CSF3, MLH1, PTGS2
30mafp449.0PTGS2, PLA2G2A, PLA2G4A
31gemcitabine44 49 1111.0PTGS2, MLH1, CSF3
32aacocf3449.0PTGS2, PLA2G2A, PLA2G4A
33ndga449.0PTGS2, PLA2G2A, PLA2G4A
34pgd2449.0PLA2G4A, PLA2G2A, PTGS2
35txb2449.0PTGS2, PLA2G2A, PLA2G4A
36thromboxane a244 2410.0PTGS2, PLA2G2A, PLA2G4A
37gf 109203x44 5910.0PLA2G4A, PLA2G2A, PTGS2
38sulindac44 1110.0MLH1, PLA2G4A, PTGS2
39prostacyclin448.9PTGS2, PLA2G2A, PLA2G4A
40etoposide44 49 59 1111.9PTGS2, MLH1, CSF3
41ns 39844 599.9PLA2G4A, PTGS2
42n acetylcysteine448.9PTGS2, PLA2G2A, PLA2G4A
43indomethacin44 59 28 1111.9PTGS2, PLA2G2A, PLA2G4A
44ly294002448.8PTGS2, PLA2G2A, PLA2G4A
45actinomycin d448.8PLA2G4A, PLA2G2A, PTGS2
46arachidonic acid44 28 11 2411.6PTGS2, PLA2G2A, PLA2G4A
47aspirin44 49 28 2411.5PTGS2, PLA2G2A, PLA2G4A, MLH1
48cisplatin44 49 59 1111.4PTGS2, PLA2G4A, MLH1, CSF3
49genistein44 28 59 2 11 2413.3PTGS2, PLA2G2A, PLA2G4A
50vegf448.0CSF3, MLH1, PLA2G4A, PLA2G2A, PTGS2

GO Terms for genes affiliated with Small Bowel Adenocarcinoma

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16Gene Ontology
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Cellular components related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057898.6PTGS2, PLA2G2A, PLA2G4A

Biological processes related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol acyl-chain remodelingGO:0361499.6PLA2G4A, PLA2G2A
2phosphatidylserine acyl-chain remodelingGO:0361509.5PLA2G2A, PLA2G4A
3phosphatidylglycerol acyl-chain remodelingGO:0361489.5PLA2G4A, PLA2G2A
4phosphatidylethanolamine acyl-chain remodelingGO:0361529.5PLA2G2A, PLA2G4A
5phosphatidylcholine acyl-chain remodelingGO:0361519.4PLA2G4A, PLA2G2A
6glycerophospholipid biosynthetic processGO:0464749.4PLA2G2A, PLA2G4A
7phosphatidic acid biosynthetic processGO:0066549.3PLA2G2A, PLA2G4A
8arachidonic acid metabolic processGO:0193698.7PLA2G4A, PTGS2

Molecular functions related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.4PLA2G2A, PLA2G4A

Products for genes affiliated with Small Bowel Adenocarcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Bowel Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet