MCID: SML032
MIFTS: 44

Small Bowel Adenocarcinoma malady

Gastrointestinal diseases, Cancer diseases, Rare diseases categories

Summaries for Small Bowel Adenocarcinoma

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34MalaCards
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MalaCards: Small Bowel Adenocarcinoma, also known as adenocarcinoma of small intestine, is related to colorectal cancer and adenocarcinoma. An important gene associated with Small Bowel Adenocarcinoma is PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid)), and among its related pathways are phospholipases and Acyl chain remodelling of PC. The compounds ly311727 and scalaradial have been mentioned in the context of this disorder. Affiliated tissues include small intestine, bone and lymph node.

Aliases & Classifications for Small Bowel Adenocarcinoma

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Sources:
50Orphanet, 63UMLS, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

small bowel adenocarcinoma 50
adenocarcinoma of small intestine 63


External Ids:

SNOMED-CT via Orphanet60 424440001
ICD10 via Orphanet27 D01.4

Related Diseases for Small Bowel Adenocarcinoma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Small Bowel Adenocarcinoma:



Diseases related to small bowel adenocarcinoma

Symptoms for Small Bowel Adenocarcinoma

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Drugs & Therapeutics for Small Bowel Adenocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Small Bowel Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Small Bowel Adenocarcinoma

Search NIH Clinical Center for Small Bowel Adenocarcinoma

Search CenterWatch for Small Bowel Adenocarcinoma

Genetic Tests for Small Bowel Adenocarcinoma

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Anatomical Context for Small Bowel Adenocarcinoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Small Bowel Adenocarcinoma:

34
Small intestine, Bone, Lymph node, Liver, Ovary

Animal Models for Small Bowel Adenocarcinoma or affiliated genes

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Publications for Small Bowel Adenocarcinoma

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Sources:
53PubMed
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Articles related to Small Bowel Adenocarcinoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Small Bowel Adenocarcinoma - Report of Two Cases and Review of Literature. (24426406)
2013
2
Spermatic cord metastasis as early manifestation of small bowel adenocarcinoma. (23662014)
2013
3
Small bowel adenocarcinoma complicating coeliac disease: a report of three cases and the literature review. (23243535)
2012
4
Small bowel adenocarcinoma. Two case reports. (22958804)
2012
5
Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers. (21586687)
2012
6
Concurrent small bowel adenocarcinoma and carcinoid tumor in Crohn's disease--case report and literature review. (21939921)
2011
7
Second-line chemotherapy with fluorouracil, leucovorin, and irinotecan (FOLFIRI regimen) in patients with advanced small bowel adenocarcinoma after failure of first-line platinum-based chemotherapy: a multicenter AGEO study. (21425142)
2011
8
Small bowel adenocarcinoma in Crohn's disease. (21336499)
2011
9
Small bowel adenocarcinoma diagnosed by double balloon enteroscopy in a patient with nonpolyposis colorectal cancer. (21770684)
2011
10
A single-institution experience with 491 cases of small bowel adenocarcinoma. (20609724)
2010
11
Small bowel adenocarcinoma: understaged and undertreated? (20458546)
2010
12
Chemotherapy of advanced small-bowel adenocarcinoma: a multicenter AGEO study. (20223786)
2010
13
Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient. (19280822)
2009
14
Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. (19544356)
2009
15
Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study. (19473375)
2009
16
Small-bowel adenocarcinoma in patient with Crohn's disease: report of a series of three cases. (18609183)
2008
17
Bevacizumab-based therapy for advanced small bowel adenocarcinoma. (18941013)
2008
18
Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma. (18759326)
2008
19
Crohn's disease-associated small bowel adenocarcinoma with pre-existing low-grade dysplasia: a case report. (17593171)
2007
20
Small bowel adenocarcinoma complicating Crohn's disease: case series and review of the literature. (18092659)
2007
21
Small-bowel adenocarcinoma: case report and review of literature on diagnosis of small-bowel tumors. (21960822)
2007
22
Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association? (18175227)
2006
23
Resection of small bowel adenocarcinoma liver metastasis combined with neoadjuvant and adjuvant chemotherapy results in extended disease-free period--a case report. (17827529)
2006
24
Adnexal mass: an unusual presentation of small-bowel adenocarcinoma. (16749659)
2006
25
Prognostic factors of primary small bowel adenocarcinoma: univariate and multivariate analysis. (16479330)
2006
26
Small bowel adenocarcinoma in Crohn's disease: a case report and review of literature. (16534894)
2006
27
Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma. (15709215)
2005
28
Early-stage small-bowel adenocarcinoma: a review of local endoscopic therapy. (16032496)
2005
29
Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. (16028284)
2005
30
Primary small bowel adenocarcinoma: a single centre evaluation of survival. (15571011)
2004
31
The role of defective mismatch repair in small bowel adenocarcinoma in celiac disease. (15466202)
2004
32
Irinotecan as salvage chemotherapy for advanced small bowel adenocarcinoma: a series of three patients. (14598944)
2003
33
An early stage small bowel adenocarcinoma with microsatellite instability phenotype in a case of hereditary nonpolyposis colorectal cancer. (12673494)
2003
34
COX-2, inflammatory secreted PLA2, and cytoplasmic PLA2 protein expression in small bowel adenocarcinomas compared with colorectal adenocarcinomas. (12591965)
2003
35
Chemotherapy in small bowel adenocarcinoma associated with celiac disease: a report of three cases. (12841670)
2003
36
Images in clinical radiology. Small bowel adenocarcinoma in a 28-year-old patient. (14748404)
2003
37
Locally advanced small-bowel adenocarcinoma missed primarily by capsule endoscopy but diagnosed by push enteroscopy. (14551867)
2003
38
Small bowel adenocarcinoma as first presentation of coeliac disease. (16491060)
2002
39
Metachronous small-bowel adenocarcinoma in coeliac disease: gluten-free diet is not protective. (9517536)
1998
40
The accuracy of CT staging of small bowel adenocarcinoma: CT/pathologic correlation. (9386295)
1997
41
Occult small bowel adenocarcinoma in a Crohn's stricture. (9059383)
1997
42
Evidence against flat dysplasia as a regional field defect in small bowel adenocarcinoma associated with celiac sprue. (9121177)
1997
43
Small bowel adenocarcinoma mimicking tubercular stricture. Role of enteroscopy in early diagnosis. (1880102)
1991
44
Neurofibromatosis and small bowel adenocarcinoma: an unrecognised association. (3119436)
1987
45
Small bowel adenocarcinoma complicating Crohn's disease. (3560126)
1987
46
Small bowel adenocarcinoma and Crohn's disease. (3818257)
1986
47
Radiology in primary small bowel adenocarcinoma. (7358250)
1980
48
Lymphocyte cytotoxicity in the X-irradiation induced rat small bowel adenocarcinoma. II. Presence of cytotoxic lymphocytes in irradiated animals. (658978)
1978
49
Lymphocyte cytotoxicity in x-irradiation-induced rat small bowel adenocarcinoma. III. Blocking by 3 M KCL extract. (627724)
1978
50
Adenosine 3' , 5'-cyclic monophsphate phosphodiesterase activities in the x-irradiation induced rat small bowel adenocarcinoma. (20895)
1977

Variations for Small Bowel Adenocarcinoma

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Expression for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Bowel Adenocarcinoma

Search GEO for disease gene expression data for Small Bowel Adenocarcinoma.

Pathways for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 31KEGG, 52PharmGKB, 54QIAGEN
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Pathways related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Anandamide biosynthesis and metabolism61
9.3PLA2G4A, PLA2G2A
2
Show member pathways
9.3PLA2G4A, PLA2G2A
39.3PLA2G2A, PLA2G4A
4
Show member pathways
aspirin triggered resolvin E biosynthesis39
9.1PTGS2, PLA2G2A
59.0PLA2G4A, PTGS2
69.0PLA2G4A, PTGS2
79.0PTGS2, PLA2G4A
8
Show member pathways
8.8PLA2G4A, PLA2G2A, CSF3
9
Show member pathways
8.5PLA2G2A, PLA2G4A, PTGS2
10
Show member pathways
8.5PLA2G2A, PLA2G4A, PTGS2
11
Show member pathways
8.5PTGS2, PLA2G4A, PLA2G2A
128.5PLA2G4A, PTGS2, PLA2G2A
13
Show member pathways
8.0PTGS2, PLA2G4A, PLA2G2A, CSF3

Compounds for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
46Novoseek, 3BitterDB, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 1956)
idCompoundScoreTop Affiliating Genes
1ly311727469.8PLA2G2A, PLA2G4A
2scalaradial469.8PLA2G4A, PLA2G2A
312-hpete469.8PLA2G2A, PLA2G4A
4manoalide469.8PLA2G2A, PLA2G4A
5p-bromophenacyl bromide469.7PLA2G4A, PLA2G2A
6bromoenol lactone469.7PLA2G4A, PLA2G2A
7melittin469.7PLA2G2A, PLA2G4A
8lysophospholipid469.7PLA2G4A, PLA2G2A
9aristolochic acid46 310.7PLA2G2A, PLA2G4A
10LysoPC(O-18:0)259.7PLA2G2A, PLA2G4A
11staurosporin469.7PLA2G4A, PLA2G2A
12LysoPC(22:4(7Z,10Z,13Z,16Z))259.7PLA2G4A, PLA2G2A
13LysoPC(22:2(13Z,16Z))259.6PLA2G4A, PLA2G2A
14LysoPC(22:1(13Z))259.6PLA2G4A, PLA2G2A
15LysoPC(22:0)259.6PLA2G4A, PLA2G2A
16LysoPC(22:5(4Z,7Z,10Z,13Z,16Z))259.6PLA2G2A, PLA2G4A
17LysoPC(22:5(7Z,10Z,13Z,16Z,19Z))259.6PLA2G2A, PLA2G4A
18LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))259.6PLA2G2A, PLA2G4A
19LysoPC(24:0)259.6PLA2G2A, PLA2G4A
20LysoPC(18:1(11Z))259.6PLA2G4A, PLA2G2A
21LysoPC(20:5(5Z,8Z,11Z,14Z,17Z))259.5PLA2G4A, PLA2G2A
22lenalidomide46 1210.5PTGS2, CSF3
23LysoPC(16:0)259.5PLA2G4A, PLA2G2A
24LysoPC(16:1(9Z))259.5PLA2G2A, PLA2G4A
25LysoPC(18:0)259.4PLA2G2A, PLA2G4A
26LysoPC(18:2(9Z,12Z))259.4PLA2G2A, PLA2G4A
27niflumic acid46 30 1211.4PLA2G4A, PTGS2
28flurbiprofen46 30 52 1212.4PLA2G4A, PTGS2
29LysoPC(18:3(6Z,9Z,12Z))259.3PLA2G2A, PLA2G4A
30LysoPC(20:0)259.3PLA2G2A, PLA2G4A
31LysoPC(18:3(9Z,12Z,15Z))259.2PLA2G2A, PLA2G4A
32fmlp469.2PLA2G2A, PLA2G4A, CSF3
33LysoPC(18:4(6Z,9Z,12Z,15Z))259.0PLA2G2A, PLA2G4A
34mafp469.0PTGS2, PLA2G4A, PLA2G2A
35aacocf3469.0PTGS2, PLA2G2A, PLA2G4A
36ndga469.0PLA2G4A, PLA2G2A, PTGS2
37pgd2469.0PTGS2, PLA2G2A, PLA2G4A
38txb2469.0PLA2G4A, PLA2G2A, PTGS2
39thromboxane a246 259.9PTGS2, PLA2G4A, PLA2G2A
40gf 109203x46 629.9PLA2G4A, PLA2G2A, PTGS2
41prostacyclin468.9PLA2G4A, PTGS2, PLA2G2A
42prostaglandin468.9PLA2G4A, PTGS2, PLA2G2A
43aspirin46 52 30 2511.9PLA2G2A, PTGS2, PLA2G4A
44n acetylcysteine468.9PTGS2, PLA2G2A, PLA2G4A
45indomethacin46 30 62 1211.9PLA2G4A, PLA2G2A, PTGS2
46ly294002468.9PLA2G4A, PLA2G2A, PTGS2
47actinomycin d468.8PLA2G2A, PLA2G4A, PTGS2
48cycloheximide468.4PLA2G4A, CSF3, PTGS2, PLA2G2A
49dexamethasone46 52 30 1211.4CSF3, PTGS2, PLA2G4A, PLA2G2A
50vegf468.4CSF3, PLA2G4A, PTGS2, PLA2G2A

GO Terms for genes affiliated with Small Bowel Adenocarcinoma

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Sources:
17Gene Ontology
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Cellular components related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057898.5PLA2G2A, PLA2G4A, PTGS2

Biological processes related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol acyl-chain remodelingGO:0361499.5PLA2G4A, PLA2G2A
2phosphatidylserine acyl-chain remodelingGO:0361509.4PLA2G4A, PLA2G2A
3phosphatidylglycerol acyl-chain remodelingGO:0361489.4PLA2G2A, PLA2G4A
4phosphatidylethanolamine acyl-chain remodelingGO:0361529.3PLA2G2A, PLA2G4A
5phosphatidylcholine acyl-chain remodelingGO:0361519.2PLA2G2A, PLA2G4A
6phosphatidic acid biosynthetic processGO:0066549.0PLA2G4A, PLA2G2A
7arachidonic acid metabolic processGO:0193699.0PTGS2, PLA2G4A

Molecular functions related to Small Bowel Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase A2 activityGO:0046239.3PLA2G2A, PLA2G4A

Products for genes affiliated with Small Bowel Adenocarcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Bowel Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet