MCID: SML001
MIFTS: 64

Small Cell Carcinoma malady

Cancer diseases, Skin diseases, Rare diseases categories
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Summaries for Small Cell Carcinoma

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Wikipedia:65 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

MalaCards based summary: Small Cell Carcinoma, also known as small cell carcinoma - intermediate cell, is related to ovarian small cell carcinoma and merkel cell carcinoma. An important gene associated with Small Cell Carcinoma is SYP (synaptophysin), and among its related pathways is Neuroscience. The drugs cisplatin and teniposide and the compounds b 723 and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and cervix, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Disease Ontology:8 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

Aliases & Classifications for Small Cell Carcinoma

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Small Cell Carcinoma, Aliases & Descriptions:

Name: Small Cell Carcinoma 8 10
Small Cell Carcinoma - Intermediate Cell 8 62
Small Cell Carcinoma, Intermediate Cell 8 62
 
Intermediate Cell Small Cell Carcinoma 8
Carcinoma, Small Cell 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:0050685
SNOMED-CT57 189557009, 5958006
NCIt39 C4099

Related Diseases for Small Cell Carcinoma

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Diseases in the Basal Cell Carcinoma family:

Large Cell Carcinoma small cell carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian small cell carcinoma32.1TTF1
2merkel cell carcinoma31.1CHGA, ENO2, SYP, NKX2-1
3pulmonary blastoma30.8NKX2-1
4vipoma30.8CHGA
5hypercalcemia30.8PTHLH, CHGA, CALCA
6teratoma30.6NKX2-1, KIT, ENO2
7neuroendocrine tumor30.5CALCA, CHGA
8neuroectodermal tumor30.5NCAM1, SYP, ENO2
9cushing's syndrome30.5CALCA, SYP, CHGA, INHA
10large cell carcinoma30.4NKX2-1, SYP, PTHLH, ENO2, CHGA
11lung cancer30.3PTHLH, TP53, CHGA, ENO2, NCAM1, NKX2-1
12tubular adenocarcinoma30.3CHGA, NCAM1, ENO2, SYP
13adenosquamous carcinoma30.3PTHLH, NKX2-1, CHGA
14transitional cell carcinoma30.3FOLH1, ENO2, TP53
15neuroendocrine carcinoma30.3SYP, NKX2-1, CALCA, ENO2, KIT, NCAM1
16meningioma30.2NCAM1, SYP, INHA
17rhabdomyosarcoma30.2NCAM1, INHA, ENO2, TP53
18pancreatic cancer30.0PTHLH, CHGA, SYP, INHA
19astrocytoma30.0TP53, INHA, NCAM1, SYP
20non-small cell lung carcinoma29.8NKX2-1, NCAM1, SYP, ENO2, CHGA, TP53
21adenocarcinoma29.6ENO2, FOLH1, NKX2-1, INHA, PTHLH, TP53
22prostate cancer29.5FOLH1, INHA, PTHLH, CHGA, ENO2
23adenoma29.3TP53, CHGA, SYP, NKX2-1, ENO2, CALCA
24lung small cell carcinoma29.2CALCA, SYP, INHA, CHGA, TP53, PTHLH
25melanoma29.1ENO2, KIT, NKX2-1, FOLH1, TP53, INHA
26breast cancer28.9CALCA, KIT, NCAM1, FOLH1, PTHLH, INHA
27prostatitis10.9
28small cell carcinoma of the bladder10.7
29prostate small cell carcinoma10.7
30gastric small cell carcinoma10.7
31esophagitis10.6
32thyroiditis10.6
33large cell neuroendocrine carcinoma10.6
34cerebral primitive neuroectodermal tumor10.6ENO2
35dysembryoplastic neuroepithelial tumor10.6SYP
36pancreatitis10.6
37melanotic neuroectodermal tumor10.5SYP
38pineoblastoma10.5SYP
39laryngeal small cell carcinoma10.5
40endometrial small cell carcinoma10.5
41adrenocortical carcinoma10.5TP53
42lambert-eaton myasthenic syndrome10.5
43subependymal giant cell astrocytoma10.4SYP, ENO2
44colon small cell carcinoma10.4
45olfactory neuroblastoma10.4ENO2, SYP
46ganglioneuroblastoma10.4SYP, ENO2
47giant cell tumor10.4CALCA
48central neurocytoma10.4CHGA, SYP
49endocrine gland cancer10.4SYP, CHGA
50thymus small cell carcinoma10.4

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to small cell carcinoma

Symptoms for Small Cell Carcinoma

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Drugs & Therapeutics for Small Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma

Search NIH Clinical Center for Small Cell Carcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Small Cell Carcinoma

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Anatomical Context for Small Cell Carcinoma

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MalaCards organs/tissues related to Small Cell Carcinoma:

32
Lung, Prostate, Cervix, Ovary, Breast, Thyroid, Kidney, Liver, Brain, Lymph node, Pancreas, Colon, Salivary gland, Bone marrow, Bone, Skeletal muscle, Adrenal gland, Skin, Tonsil, Pituitary, Bronchial epithelium, Cerebellum, Heart, Testis, Testes, Myeloid, Monocytes, B cells, Tongue, Trachea, Appendix, Neutrophil

Animal Models for Small Cell Carcinoma or affiliated genes

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Publications for Small Cell Carcinoma

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Articles related to Small Cell Carcinoma:

(show top 50)    (show all 760)
idTitleAuthorsYear
1
A rare case of breast cancer showing distinct TTF-1 nuclear expression: small cell carcinoma or not? (25110164)
2014
2
Primary small cell carcinoma of prostate without immunoreactive neuroendocrine proteins but with expressions of KIT and platelet-derived growth factor-I+ (25195713)
2014
3
Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination. (24396449)
2014
4
Small cell carcinoma of the head and neck: report of three cases. (23927815)
2013
5
Primary small cell carcinoma of kidney after renal transplantation: a case report and literature review. (24255587)
2013
6
Merkel cell polyomavirus and extrapulmonary small cell carcinoma. (24137462)
2013
7
Clinical impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of small cell carcinoma of the prostate. (23218515)
2013
8
Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type. (23459374)
2013
9
Small cell carcinoma of the colon arising in a carcinoid tumor. (23564820)
2013
10
Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures. (22316327)
2012
11
Small-cell carcinoma of the lung detected by CT screening: stage distribution and curability. (22189270)
2012
12
New treatment trends in small cell carcinoma of the urinary bladder. (23335548)
2012
13
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. (21210145)
2011
14
Pure small cell carcinoma of the prostate: a case report and literature review. (21475596)
2011
15
Cytokeratin (CK7 and CK20) switching in the natural history of pulmonary small cell carcinoma: an interesting but unpublished phenomenon. (21248319)
2011
16
Back pain and leg complaints that revealed non-small cell carcinoma: a case study. (22014908)
2011
17
Long-term survival and improved quality of life after chemoradiotherapy to treat esophageal small cell carcinoma: a report of two cases. (22086689)
2011
18
Phase II study of weekly irinotecan plus cisplatin in patients with previously untreated extensive-stage extrapulmonary small cell carcinoma. (21734424)
2011
19
Small cell carcinoma of the urinary bladder. (20017108)
2010
20
A complete response in small cell carcinoma of the esophagus treated by s-1/cisplatin combined chemotherapy and radiotherapy. (20437111)
2010
21
Sequential treatment of superior vena cava syndrome caused by of non-small cell carcinoma lung cancer (NSCLC) with vascular stenting and iodine-125 implantation. (19645521)
2009
22
Small cell carcinoma of the uterine cervix: clinicopathologic study of 20 cases in a single center. (19899411)
2009
23
Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report. (19715991)
2009
24
Analysis of ThinPrep cytology in establishing the diagnosis of small cell carcinoma of lung. (19347830)
2009
25
Metastasis to eyelid as initial presentation of non-small cell carcinoma. (19966662)
2009
26
Successful treatment for advanced small cell carcinoma of the ovary. (18293381)
2008
27
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. (18580310)
2008
28
A rare case of ectopic adrenocorticotropic hormone syndrome in small cell carcinoma of the vagina: a case report. (18369310)
2008
29
Small cell carcinoma of the breast. (17270668)
2007
30
The prognostic value of carcinoembryonic antigen in T1N1M0 and T2N1M0 non-small cell carcinoma of the lung. (17643308)
2007
31
Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. (17727473)
2007
32
Small cell carcinoma of the urinary bladder--histogenesis, genetics, diagnosis, biomarkers, treatment, and prognosis. (17536302)
2007
33
Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. (17805055)
2007
34
Use of dynamic contrast-enhanced magnetic resonance imaging for differentiating between aggressive rectal tumours: two cases with small cell carcinoma and malignant melanoma. (17148806)
2006
35
Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents: a prognostically unfavorable but curable disease. (16998935)
2006
36
Gallbladder small cell carcinoma Xenograft established by serial transplantation in nude mice. (16475682)
2006
37
Combined small cell carcinoma with pulmonary blastoma and adenocarcinoma: case report and clonality analysis. (17046168)
2006
38
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. (15722802)
2005
39
Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon. (15383629)
2004
40
Small cell carcinoma of the prostate expressing prostate-specific antigen and showing syndrome of inappropriate secretion of antidiuretic hormone: an autopsy case report. (14629757)
2003
41
Cerebrospinal fluid gastrin releasing peptide in the diagnosis of leptomeningeal metastases from small cell carcinoma. (11391593)
2001
42
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. (11175640)
2001
43
Ovarian small cell carcinoma: a rare neoplasm in a 15-year-old female. (10888454)
2000
44
Small cell carcinoma of the breast: a clinicopathologic and immunohistochemical study of nine patients. (10976697)
2000
45
Small cell carcinoma of the prostate: a case report]. (9783201)
1998
46
Ovarian small cell carcinoma with K-ras mutation: a case report with genetic analysis. (8543315)
1996
47
Neurofilament immunoreactivity in Merkel-cell tumors: a differentiating feature from small-cell carcinoma. (7678934)
1993
48
Neuroendocrine differentiation in mA1llerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed mA1llerian tumor containing small-cell carcinoma. (3020961)
1986
49
Physalaemin-like immunoreactivity from human lung small cell carcinoma: isocratic reversed-phase HPLC analysis of the chemically modified peptide. (2999922)
1985
50
Human lung small-cell carcinoma contains bombesin. (6285381)
1982

Variations for Small Cell Carcinoma

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Expression for genes affiliated with Small Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for genes affiliated with Small Cell Carcinoma

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Pathways related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7ENO2, NCAM1, NKX2-1, SYP

Compounds for genes affiliated with Small Cell Carcinoma

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Compounds related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1b 723449.8CHGA, SYP, NKX2-1
2111in-pentetreotide449.7CALCA, SYP, CHGA
3s 100449.5CHGA, ENO2, SYP
4l-amino acid449.4ENO2, SYP, CHGA
5gnrh449.3INHA, NCAM1, CHGA, NKX2-1
6smcc449.2NCAM1, SYP, ENO2, CHGA
7gold449.1SYP, KIT, NCAM1, CHGA, FOLH1
8matrigel449.1CHGA, PTHLH, FOLH1, NCAM1
9mibg449.1CHGA, CALCA, ENO2
10dbc-amp449.1ENO2, NCAM1, SYP, PTHLH
11estracyt449.1ENO2, CHGA
12bromodeoxyuridine449.0PTHLH, CHGA, NCAM1, ENO2
13gaba449.0SYP, CHGA, ENO2, NCAM1
14histamine44 28 2410.9CHGA, NCAM1, KIT, SYP, CALCA
15vincristine44 50 1110.9PTHLH, KIT, TP53, CALCA, NCAM1
16etoposide44 50 61 1111.8CHGA, TP53, SYP, ENO2
175-hydroxytryptamine448.8CALCA, CHGA, ENO2, SYP
18formaldehyde44 249.8SYP, CHGA, NKX2-1, ENO2, KIT
19octreotide44 61 28 1111.8PTHLH, CHGA, CALCA, ENO2
20docetaxel44 50 61 1111.7TP53, KIT, FOLH1, ENO2
21spec-t448.7ENO2, CALCA, FOLH1
22steroid448.7SYP, NKX2-1, INHA, PTHLH, CHGA, KIT
23oligonucleotide448.7CHGA, NKX2-1, KIT, INHA, TP53
24glycogen44 249.6ENO2, KIT, SYP, CHGA, PTHLH
25cisplatin44 50 61 1111.6ENO2, PTHLH, SYP, CHGA, TP53
26nmda44 289.6ENO2, SYP, FOLH1, NCAM1
27guanine44 24 1110.6TP53, CHGA, CALCA, ENO2, SYP
28cyclic amp44 249.5NKX2-1, CALCA, SYP, INHA, PTHLH, CHGA
29norepinephrine44 24 1110.5PTHLH, ENO2, CALCA, SYP, CHGA
30dopamine44 28 24 1111.5SYP, CALCA, ENO2, CHGA, NCAM1
31acth448.4CALCA, INHA, CHGA, ENO2, SYP
32dexamethasone44 50 28 1111.4PTHLH, CHGA, SYP, ENO2, NCAM1, NKX2-1
33thymidine44 249.3KIT, ENO2, TP53, PTHLH, FOLH1
34acetylcholine44 50 28 24 1112.2SYP, NCAM1, PTHLH, ENO2, CALCA, CHGA
35creatinine448.2NCAM1, CHGA, SYP, CALCA, PTHLH, ENO2
36lactate448.1ENO2, NCAM1, CALCA, CHGA, KIT, PTHLH
37serine448.0CHGA, NCAM1, SYP, FOLH1, KIT, PTHLH
38hematoxylin448.0ENO2, KIT, NCAM1, NKX2-1, SYP, CHGA
39glutamate448.0CHGA, ENO2, NCAM1, FOLH1, SYP, CALCA
40nitric oxide44 24 119.8SYP, PTHLH, NCAM1, ENO2, KIT, CHGA
41retinoic acid44 248.8TP53, KIT, PTHLH, CHGA, ENO2, SYP
42forskolin44 50 119.7ENO2, CALCA, INHA, PTHLH, CHGA, NKX2-1
43ribonucleic acid447.7CHGA, FOLH1, INHA, ENO2, NKX2-1, KIT
44tyrosine447.6NKX2-1, ENO2, NCAM1, INHA, PTHLH, CHGA
45paraffin447.3SYP, KIT, ENO2, NCAM1, NKX2-1, PTHLH
46progesterone44 28 61 24 1111.3ENO2, TP53, KIT, NCAM1, NKX2-1, SYP
47calcium44 50 24 1110.3KIT, PTHLH, ENO2, NCAM1, CALCA, SYP
48vegf447.0TP53, SYP, CHGA, FOLH1, CALCA, NCAM1
49testosterone44 61 24 119.9ENO2, KIT, FOLH1, NCAM1, CALCA, SYP
50estrogen446.7KIT, NCAM1, NKX2-1, CALCA, SYP, INHA

GO Terms for genes affiliated with Small Cell Carcinoma

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Cellular components related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1NCAM1, CHGA, PTHLH, INHA
2photoreceptor inner segmentGO:0019178.9ENO2, INHA

Biological processes related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:0074929.9NKX2-1, PTHLH
2negative regulation of DNA replicationGO:0081569.8TP53, TTF1
3ovarian follicle developmentGO:0015419.6KIT, INHA
4positive regulation of cAMP biosynthetic processGO:0308199.5PTHLH, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.4CALCA, PTHLH
6erythrocyte differentiationGO:0302189.3KIT, INHA
7cell-cell signalingGO:0072679.1CALCA, PTHLH, INHA

Molecular functions related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.0NCAM1, CALCA, SYP, TP53
2hormone activityGO:0051798.7CALCA, PTHLH, INHA

Products for genes affiliated with Small Cell Carcinoma

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Sources for Small Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet