MCID: SML001
MIFTS: 64

Small Cell Carcinoma malady

Cancer diseases category

Summaries for Small Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

MalaCards: Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to lung small cell carcinoma and bladder carcinoma. An important gene associated with Small Cell Carcinoma is SYP (synaptophysin), and among its related pathways is Neuroscience. The drugs cisplatin and cisplatin pwdr and the compounds testosterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and cervix, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology:8 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

Aliases & Classifications for Small Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

small cell carcinoma 8 10
small cell carcinoma, intermediate cell 8 60
small cell carcinoma - intermediate cell 8
intermediate cell small cell carcinoma 8
carcinoma, small cell 60


External Ids:

Disease Ontology8 DOID:0050685
SNOMED-CT56 5958006, 189557009
NCIt39 C4099

Related Diseases for Small Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

small cell carcinoma Large Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1lung small cell carcinoma31.6KIT, CXCR2, INHA, CHGA, SYP, NCAM1
2bladder carcinoma31.3TP53
3prostate small cell carcinoma31.3INA
4ovarian small cell carcinoma31.2TTF1
5non-small cell lung carcinoma31.2NKX2-1, NCAM1, SYP, CHGA, ENO2, TP53
6neuroendocrine carcinoma31.1ENO2, KIT, CHGA, SYP, NCAM1, NKX2-1
7squamous cell carcinoma31.0CALB2, EGR1, NKX2-1, SYP, CHGA, INHA
8adenocarcinoma31.0CALB2, FOLH1, GAST, TP53, ENO2, PTHLH
9merkel cell carcinoma30.9NKX2-1, NCAM1, SYP, CHGA, KIT, ENO2
10large cell carcinoma30.9NKX2-1, SYP, CHGA, PTHLH, ENO2
11esophagitis30.8GAST
12thyroiditis30.8CALCA
13lung cancer30.7EGR1, NKX2-1, NCAM1, CHGA, PTHLH, ENO2
14hypercalcemia30.5CALCA, GAST, CHGA, PTHLH
15cushing's syndrome30.5CALCA, SYP, CHGA, INHA
16neuroendocrine tumor30.4CALCA, GAST, NKX2-1, NCAM1, SYP, CHGA
17endometrial carcinoma30.4CALB2, NKX2-1, INHA, TP53
18neuropathy30.4CALCA
19transitional cell carcinoma30.3CALB2, FOLH1, ENO2, TP53
20ulcerative colitis30.3TP53
21prostate cancer30.2FOLH1, EGR1, CHGA, INHA, PTHLH, ENO2
22rhabdomyosarcoma30.2TP53, ENO2, INHA, NCAM1, CALB2
23malignant mesothelioma30.2CALB2, NKX2-1
24adenoma30.0TP53, ENO2, INHA, CHGA, SYP, NKX2-1
25melanoma30.0CALB2, FOLH1, EGR1, NKX2-1, INHA, CXCR2
26astrocytoma30.0EGR1, NCAM1, SYP, INHA, INA, CXCR2
27breast cancer30.0FOLH1, EGR1, NKX2-1, SYP, CHGA, PTHLH
28sarcoma30.0CALB2, FOLH1, KIT, ENO2, TP53
29meningioma30.0CALB2, NCAM1, SYP, INHA
30pancreatic cancer30.0TP53, PTHLH, CXCR2, CHGA, GAST
31tubular adenocarcinoma30.0NCAM1, SYP, CHGA, ENO2
32hepatocellular carcinoma30.0TP53, CXCR2, NKX2-1, EGR1
33glioblastoma multiforme30.0TP53, KIT, CXCR2, NCAM1, EGR1
34ovarian cancer30.0TP53, INHA, CALB2
35pulmonary blastoma30.0NKX2-1
36adenosquamous carcinoma30.0NKX2-1, CHGA, PTHLH
37vipoma30.0CHGA, GAST
38benign mesothelioma30.0CALB2, NKX2-1, TP53
39achalasia30.0GAST
40rheumatoid arthritis30.0CXCR2, EGR1
41retinoblastoma30.0SYP, ENO2, TP53
42arthritis30.0CXCR2, CALCA
43ischemia30.0NCAM1, EGR1
44cholangiocarcinoma30.0TP53, NCAM1
45brain cancer30.0SYP, TP53
46stomach cancer30.0TP53, CXCR2, CHGA, GAST
47leukemia30.0EGR1, NCAM1, KIT, TP53
48prostatitis10.9
49esophagus small cell carcinoma10.8
50cervix small cell carcinoma10.8

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to small cell carcinoma

Clinical Features for Small Cell Carcinoma

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Drugs & Therapeutics for Small Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Small Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma

Search NIH Clinical Center for Small Cell Carcinoma

Search CenterWatch for Small Cell Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Small Cell Carcinoma

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Anatomical Context for Small Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Small Cell Carcinoma:

32
Lung, Prostate, Cervix, Breast, Endothelial, Ovary, Lymph node, Thyroid, Brain, Liver, Kidney, Colon, Bone, Pancreas, Small intestine, Bone marrow, Testes, Salivary gland, Pituitary, Testis, T cells, B cells, Adrenal gland, Skin, Skeletal muscle, Tonsil, Tongue, Bronchial epithelium, Trachea, Thymus, Cerebellum, Heart, Monocytes, Myeloid, Appendix

Animal Models for Small Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Small Cell Carcinoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2TP53, CALCA, CALB2, FOLH1, EGR1, NKX2-1
2MP:000538511.2CALCA, FOLH1, EGR1, NEK8, NKX2-1, CHGA
3MP:001076811.1NKX2-1, NEK8, EGR1, GAST, CALCA, NCAM1
4MP:000538611.1CALCA, CALB2, FOLH1, EGR1, NEK8, NKX2-1
5MP:000200611.0CALCA, GAST, EGR1, NKX2-1, INHA, CXCR2
6MP:000538810.9EGR1, NEK8, CXCR2, PTHLH, ENO2, TP53
7MP:000537610.9CALCA, FOLH1, GAST, EGR1, NEK8, CNN1
8MP:000537810.9NEK8, NKX2-1, NCAM1, CHGA, INHA, CXCR2
9MP:000537910.8GAST, EGR1, INHA, KIT, TP53
10MP:000539010.7NKX2-1, CNN1, INHA, PTHLH
11MP:000287310.7CALCA, CALB2, SYP, INHA, INA, KIT
12MP:000536710.6CXCR2, CHGA, NEK8
13MP:000538910.3EGR1, INHA, CXCR2, TP53

Publications for Small Cell Carcinoma

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50PubMed
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Articles related to Small Cell Carcinoma:

(show top 50)    (show all 2078)
idTitleAuthorsYear
1
Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination. (24396449)
2014
2
NSE can predict the sensitivity to definitive chemoradiotherapy of small cell carcinoma of esophagus. (24307347)
2014
3
Multidisciplinary modalities achieve encouraging long-term survival in resectable limited-disease esophageal small cell carcinoma. (23874925)
2013
4
Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor Treatment. (23483646)
2013
5
Clinical significance of preoperative neutrophil lymphocyte ratio versus platelet lymphocyte ratio in patients with small cell carcinoma of the esophagus. (24089602)
2013
6
A useful treatment for patients with advanced mixed-type small cell neuroendocrine carcinoma of the prostate: A case report. (23426029)
2013
7
Diagnosis, clinicopathologic features, treatment, and prognosis of small cell carcinoma of the uterine cervix; Kansai Clinical Oncology Group/Intergroup study in Japan. (23480872)
2013
8
Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype. (22656670)
2012
9
Small cell neuroendocrine carcinoma of the prostate: incidence and a report of four cases with an examination of KIT and PDGFRA. (22127977)
2012
10
Synergistic antitumor effect of I^-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. (21904777)
2011
11
The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis. (21156971)
2011
12
ERG gene rearrangements are common in prostatic small cell carcinomas. (21336263)
2011
13
Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma. (21521025)
2011
14
EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry. (20472851)
2010
15
Histologic-type specific role of cell cycle regulators in non-small cell lung carcinoma. (19691991)
2010
16
Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. (20406986)
2010
17
Activity of panitumumab alone or with chemotherapy in non-small cell lung carcinoma cell lines expressing mutant epidermal growth factor receptor. (19509246)
2009
18
Prognostic value and therapeutic consequences of vascular invasion in non-small cell lung carcinoma. (18790545)
2009
19
An unusual presentation of non-small cell lung carcinoma. (22162741)
2009
20
Protocol for the examination of specimens from patients with primary non-small cell carcinoma, small cell carcinoma, or carcinoid tumor of the lung. (19792044)
2009
21
Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells. (19010899)
2008
22
Stage I small cell carcinoma of the endometrium: survival and management options. (17943466)
2008
23
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. (18547617)
2008
24
Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma. (17453000)
2007
25
Defective expression of transforming growth factor beta type II receptor (TGFBR2) in the large cell variant of non-small cell lung carcinoma. (17566598)
2007
26
Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells. (17261084)
2007
27
Time delay and its effect on survival in malaysian patients with non-small cell lung carcinoma. (22589589)
2006
28
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). (16495931)
2006
29
Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness. (17095061)
2006
30
CD56: a useful tool for the diagnosis of small cell lung carcinomas on biopsies with extensive crush artefact. (16126882)
2005
31
Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. (15639721)
2005
32
The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. (12819188)
2003
33
Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 non-small cell lung carcinoma cells. (14688473)
2003
34
Vimentin and leukocyte common antigen-negative molding cells in pleural effusions of patients with small cell lung carcinoma. (14674074)
2003
35
Diagnosing and treating small-cell carcinomas of prostatic origin. (11805477)
2002
36
Primitive neuroectodermal tumor or small cell carcinoma of the kidney, a rare neoplasm: case report. (17660676)
2002
37
Defective caspase-3 relocalization in non-small cell lung carcinoma. (11420700)
2001
38
Clinical significance of the expression of lung resistance protein in non-small cell lung carcinomas]. (11718033)
2001
39
Ovarian small cell carcinoma: a rare neoplasm in a 15-year-old female. (10888454)
2000
40
Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. (9888482)
1999
41
Detection of chromogranin A mRNA in small cell lung carcinoma using a new, highly sensitive in situ hybridization method with a non-radioisotope oligonucleotide probe. (9452263)
1998
42
A review of ifosfamide and vinorelbine in advanced non-small cell carcinoma of the lung. (9535205)
1998
43
Phenotypic alterations of small cell lung carcinoma induced by different levels of wild-type p53 expression. (10200459)
1998
44
Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437. (9365537)
1997
45
Correlation between multidrug resistance and the degree of differentiation of non-small-cell bronchopulmonary carcinoma (NSCLC) in vitro and in vivo. (9494574)
1997
46
Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. (9357056)
1997
47
In vitro and in vivo expressions of transforming growth factor-alpha and tyrosine kinase receptors in human non-small-cell lung carcinomas. (8097369)
1993
48
Elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas. (1338282)
1992
49
Carboplatin, vinblastine and mitomycin-C in the treatment of non-small cell bronchogenic carcinoma. (1325545)
1992
50
Photoaffinity labeling of GDP-fucose:nLcOse4Cer alpha 1----3-fucosyltransferase from human small cell lung carcinoma NCI-H69 cells with the GDP-fucose analog GDP-hexanolaminyl-4-azidosalicylic acid. (2165495)
1990

Genetic Variations for Small Cell Carcinoma

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Expression for genes affiliated with Small Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for genes affiliated with Small Cell Carcinoma

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4Cell Signaling Technology
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Pathways related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7ENO2, SYP, NCAM1, NKX2-1, EGR1

Compounds for genes affiliated with Small Cell Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2414.4TMPRSS2, CALCA, CALB2, FOLH1, GAST, EGR1
2vegf4411.4NCAM1, EGR1, GAST, FOLH1, CALCA, SYP
3tyrosine4411.3CALB2, GAST, EGR1, NKX2-1, NCAM1, SYP
4progesterone44 59 28 11 2415.3NCAM1, NKX2-1, EGR1, CALB2, SYP, CHGA
5retinoic acid44 2412.3EGR1, NKX2-1, NCAM1, SYP, CHGA, INA
6paraffin4411.3CALB2, NKX2-1, NCAM1, SYP, CHGA, INHA
7calcium44 49 11 2414.3NCAM1, EGR1, GAST, CALB2, CALCA, SYP
8nitric oxide44 11 2413.3CALCA, CALB2, EGR1, NCAM1, SYP, CHGA
9acetylcholine44 49 28 11 2415.3CALCA, CALB2, GAST, EGR1, NCAM1, SYP
10hematoxylin4411.2CALB2, NKX2-1, NCAM1, SYP, CHGA, INHA
11ribonucleic acid4411.2FOLH1, EGR1, NKX2-1, CHGA, INHA, KIT
12thymidine44 2412.2CALB2, FOLH1, GAST, EGR1, KIT, PTHLH
13norepinephrine44 11 2413.1CALCA, GAST, EGR1, SYP, CHGA, PTHLH
14serine4411.1TMPRSS2, CXCR2, SYP, NCAM1, NKX2-1, FOLH1
15dopamine44 28 11 2414.1CALB2, GAST, EGR1, NCAM1, CHGA, ENO2
165-hydroxytryptamine4411.1CALCA, CALB2, GAST, SYP, CHGA, ENO2
17cisplatin44 49 59 1114.1GAST, EGR1, SYP, CHGA, PTHLH, ENO2
18gnrh4411.1GAST, EGR1, NKX2-1, NCAM1, CHGA, INHA
19gaba4411.1CALB2, GAST, NCAM1, SYP, CHGA, ENO2
20smcc4411.1NCAM1, SYP, CHGA, ENO2
21acth4411.1ENO2, INHA, CHGA, SYP, GAST
22octreotide44 59 28 1114.1CALCA, GAST, CHGA, PTHLH, ENO2
23dbc-amp4411.1EGR1, NCAM1, SYP, PTHLH, ENO2
24matrigel4411.1FOLH1, EGR1, NCAM1, CHGA, CXCR2, PTHLH
25forskolin44 49 1113.0CALCA, EGR1, NKX2-1, ENO2
26cyclic amp44 2412.0CALCA, EGR1, NKX2-1, SYP, CHGA, INHA
27glutamate4411.0FOLH1, GAST, NCAM1
28vincristine44 49 1113.0CALCA, NCAM1, KIT, PTHLH, TP53
29creatinine4411.0PTHLH, CHGA, SYP, NCAM1, GAST
30b 7234411.0CALB2, NKX2-1, SYP, CHGA
31histamine44 28 2413.0KIT, CHGA, SYP, NCAM1, GAST, CALCA
32estrogen4411.0CALB2
33dexamethasone44 49 28 1113.9ENO2, NKX2-1, EGR1
34bromodeoxyuridine4410.9GAST, NCAM1, CHGA, PTHLH, ENO2
35nmda44 2811.9FOLH1, EGR1, NCAM1, SYP
36guanine44 11 2412.9EGR1, CALCA
37111in-pentetreotide4410.9CALCA, SYP, CHGA
38paclitaxel44 49 1112.9TP53, CHGA, EGR1, CALB2
39gold4410.9CHGA, SYP, FOLH1
40formaldehyde44 2411.9ENO2, KIT, CHGA, SYP, NKX2-1
41ionomycin4410.9CALB2, EGR1, SYP, CHGA, PTHLH
42steroid4410.8CALB2, NKX2-1, SYP, INHA, PTHLH
43s 1004410.8SYP, CHGA, ENO2
44lactate4410.8CALCA, NCAM1, CHGA, KIT, PTHLH, ENO2
45mucicarmine4410.7CALB2, NKX2-1, SYP
46alanine4410.7GAST, NCAM1, INHA, CXCR2, PTHLH, ENO2
47mibg4410.7CALCA, CHGA, ENO2
48silver4410.6ENO2, CHGA, SYP, CALB2
49amine4410.5GAST, SYP, CHGA, ENO2
505-hydroxyindoleacetic acid44 2411.3ENO2, CHGA, GAST

GO Terms for genes affiliated with Small Cell Carcinoma

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16Gene Ontology
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Cellular components related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TMPRSS2, PTHLH, INHA, CHGA, NCAM1, GAST

Biological processes related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oligodendrocyte differentiationGO:04870910.5NKX2-1, EGR1

Molecular functions related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6PTHLH, INHA, GAST, CALCA

Products for genes affiliated with Small Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Small Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet