MCID: SML001
MIFTS: 62

Small Cell Carcinoma malady

Cancer category

Summaries for Small Cell Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

MalaCards: Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to bladder carcinoma and prostate small cell carcinoma. An important gene associated with Small Cell Carcinoma is SYP (synaptophysin), and among its related pathways is Neuroscience. The drugs cisplatin and cisplatin pwdr and the compounds testosterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology:8 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

Aliases & Classifications for Small Cell Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

small cell carcinoma 8 10
small cell carcinoma, intermediate cell 8 61
small cell carcinoma - intermediate cell 8
intermediate cell small cell carcinoma 8
carcinoma, small cell 61


External Ids:

Disease Ontology8 DOID:0050685
SNOMED-CT57 5958006, 189557009
NCIt40 C4099

Related Diseases for Small Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma31.4TP53
2prostate small cell carcinoma31.2INA
3neuroendocrine carcinoma31.2ENO2, KIT, CHGA, SYP, NCAM1, NKX2-1
4squamous cell carcinoma31.0CALB2, EGR1, NKX2-1, SYP, CHGA, INHA
5adenocarcinoma31.0CALB2, FOLH1, GAST, TP53, ENO2, PTHLH
6merkel cell carcinoma30.9NKX2-1, NCAM1, SYP, CHGA, KIT, ENO2
7large cell carcinoma30.9NKX2-1, SYP, CHGA, PTHLH, ENO2
8hypercalcemia30.6CALCA, GAST, CHGA, PTHLH
9cushing's syndrome30.5CALCA, SYP, CHGA, INHA
10transitional cell carcinoma30.3CALB2, FOLH1, ENO2, TP53
11ulcerative colitis30.3TP53
12thymic carcinoma30.2KIT, SYP, NKX2-1, CALB2
13teratoma30.2ENO2, KIT, NKX2-1
14paraneoplastic syndromes30.2PTHLH
15adenoma30.0TP53, ENO2, INHA, CHGA, SYP, NKX2-1
16astrocytoma30.0EGR1, NCAM1, SYP, INHA, INA, CXCR2
17burkitt's lymphoma30.0CALB2, EGR1, NCAM1, INHA, PTHLH, ENO2
18tubular adenocarcinoma30.0NCAM1, SYP, CHGA, ENO2
19adenosquamous carcinoma30.0NKX2-1, CHGA, PTHLH
20vipoma30.0CHGA, GAST
21benign mesothelioma30.0CALB2, NKX2-1, TP53
22achalasia30.0GAST
23arthritis30.0CXCR2, CALCA
24brain cancer30.0SYP, TP53
25pancreatic endocrine carcinoma30.0PTHLH, GAST
26stomach cancer30.0TP53, CXCR2, CHGA, GAST
27esophagus small cell carcinoma10.8
28cervix small cell carcinoma10.8
29gastric small cell carcinoma10.7
30ureter small cell carcinoma10.6
31hypercalcemic type ovarian small cell carcinoma10.5
32gallbladder small cell carcinoma10.5
33colon small cell carcinoma10.5
34lambert syndrome10.5
35lambert-eaton myasthenic syndrome10.5
36pulmonary type ovarian small cell carcinoma10.5
37laryngeal small cell carcinoma10.5
38bile duct carcinoma10.5
39endometrial small cell carcinoma10.4
40acute pancreatitis10.4
41lung combined type small cell carcinoma10.4
42small cell carcinoma of the bladder10.4
43bone carcinoma10.3
44thymus small cell carcinoma10.3
45ampulla of vater small cell carcinoma10.3
46pleomorphic carcinoma10.3
47basal cell carcinoma10.3
48parathyroid carcinoma10.2
49basaloid squamous cell carcinoma10.2
50lung occult small cell carcinoma10.2

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to small cell carcinoma

Clinical Features for Small Cell Carcinoma

Drugs & Therapeutics for Small Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Small Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma

Search NIH Clinical Center for Small Cell Carcinoma

Search CenterWatch for Small Cell Carcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Small Cell Carcinoma

Anatomical Context for Small Cell Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Small Cell Carcinoma:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Thymus, Cerebellum, Heart, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Prostate, Testis, Cervix, Tonsil, Myeloid, Monocytes, T cells, B cells, Endothelial, Trachea, Bronchial epithelium, Appendix, Pituitary, Testis germ

Animal Models for Small Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Small Cell Carcinoma

Sources:
51PubMed
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Articles related to Small Cell Carcinoma:

(show top 50)    (show all 2087)
idTitleAuthorsYear
1
Metastatic small cell neuroendocrine carcinoma of the pelvic floor. (24065309)
2013
2
Emerging mitotic inhibitors for non-small cell carcinoma. (23448156)
2013
3
Lambert-Eaton myasthenic syndrome in mixed small cell carcinoma and adenocarcinoma of extrapulmonary origin. (23298881)
2013
4
The Cost-Utility Analysis of PET-Scan in Diagnosis and Treatment of Non-Small Cell Lung Carcinoma in Iran. (24046780)
2013
5
Small cell carcinoma of the prostate after high-dose-rate brachytherapy for low-risk prostatic adenocarcinoma. (23255893)
2013
6
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
7
Breast metaplastic carcinoma with unusual small cell component. (23507669)
2012
8
c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas. (22198430)
2012
9
Small cell carcinoma of the ileum that developed 10 years after total gastrectomy for gastric signet-ring cell carcinoma. (22417855)
2012
10
Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. (22670171)
2012
11
PTEN expression in non small cell lung carcinoma based on digitized image analysis. (23335531)
2012
12
A comparison of Twist and E-cadherin protein expression in primary non-small-cell lung carcinoma and corresponding metastases. (21376622)
2011
13
Evaluation of treatment response after nonoperative therapy for early-stage non-small cell lung carcinoma. (21263266)
2011
14
The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma. (20477813)
2010
15
Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. (20068099)
2010
16
Primary small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural evaluation. (20594044)
2010
17
Small-cell carcinoma of the endometrium presenting as Cushing's syndrome. (19834252)
2010
18
Small cell carcinoma of the lung: an incidental finding on routine cardiac imaging. (19752008)
2010
19
Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma. (19962781)
2010
20
Analysis of ThinPrep cytology in establishing the diagnosis of small cell carcinoma of lung. (19347830)
2009
21
Dermatomyositis and small cell carcinoma of the bladder. (19826157)
2009
22
CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells. (18624931)
2009
23
Small cell carcinoma in Pancoast syndrome. (19287924)
2009
24
Vascular endothelial growth factor expression and neovascularization in non--small cell lung carcinoma. (18849317)
2009
25
Circulating human interleukin-8 as an indicator of cancer progression in a nude rat orthotopic human non-small cell lung carcinoma model. (18708412)
2008
26
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. (18515524)
2008
27
Long-term remission of metastatic small cell carcinoma of the prostate. (18342209)
2008
28
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma. (18587322)
2008
29
Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. (17805055)
2007
30
Diagnosis of primary ureteral small cell carcinoma in instrumented urine cytology. (17558869)
2007
31
Long-term survival of patients treated with photodynamic therapy for carcinoma in situ and early non-small-cell lung carcinoma. (17565719)
2007
32
c-Met and HGF expression in non-small-cell lung carcinomas]. (17598453)
2007
33
TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material. (16680154)
2006
34
A case of small cell carcinoma of the lung associated with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome]. (16482925)
2006
35
Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice. (15685617)
2005
36
Primary ovarian small cell carcinoma of the pulmonary type: a case report and review of the literature. (15032292)
2004
37
Galectin-3 expression in non-small cell lung carcinoma. (15279903)
2004
38
A pulmonary metastatic model of human non-small cell lung carcinoma cells that produce a neutrophil elastase-like molecule in severe combined immunodeficiency mice. (12684318)
2003
39
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. (11986780)
2002
40
Expression of heat shock proteins HSP70 and HSP27 in primary non-small cell lung carcinomas. An immunohistochemical study. (11396134)
2001
41
Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. (11678615)
2001
42
Staging of bronchogenic carcinoma, non-small cell lung carcinoma. American College of Radiology. ACR Appropriateness Criteria. (11037472)
2000
43
Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells. (11062732)
2000
44
Expression of platelet-derived endothelial cell growth factor in non-small cell lung carcinomas: relationship to various biological factors. (9772289)
1998
45
Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells. (8930400)
1996
46
Apoptosis occurs independently of bcl-2 and p53 over-expression in non-small cell lung carcinoma. (8818693)
1996
47
A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma. (7511893)
1994
48
The inhibitory effect of the combination of antineoplaston A-10 injection with a small dose of cis-diamminedichloroplatinum on cell and tumor growth of human hepatocellular carcinoma. (1377669)
1992
49
Phase II trial of intravenous 6-thioguanine for unresectable or metastatic non-small cell bronchogenic carcinoma. (1666631)
1991
50
Early detection of response in small cell bronchogenic carcinoma by changes in serum concentrations of creatine kinase, neuron specific enolase, calcitonin, ACTH, serotonin and gastrin releasing peptide. (2842159)
1988

Genetic Variations for Small Cell Carcinoma

Expression for genes affiliated with Small Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for genes affiliated with Small Cell Carcinoma

Sources:
4Cell Signaling Technology
See all sources

Pathways related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7ENO2, SYP, NCAM1, NKX2-1, EGR1

Compounds for genes affiliated with Small Cell Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1testosterone45 60 11 2414.4TMPRSS2, CALCA, CALB2, FOLH1, GAST, EGR1
2vegf4511.4NCAM1, EGR1, GAST, FOLH1, CALCA, SYP
3tyrosine4511.3CALB2, GAST, EGR1, NKX2-1, NCAM1, SYP
4progesterone45 60 29 11 2415.3NCAM1, NKX2-1, EGR1, CALB2, SYP, CHGA
5retinoic acid45 2412.3EGR1, NKX2-1, NCAM1, SYP, CHGA, INA
6paraffin4511.3CALB2, NKX2-1, NCAM1, SYP, CHGA, INHA
7calcium45 50 11 2414.3NCAM1, EGR1, GAST, CALB2, CALCA, SYP
8nitric oxide45 11 2413.3CALCA, CALB2, EGR1, NCAM1, SYP, CHGA
9acetylcholine45 50 29 11 2415.3CALCA, CALB2, GAST, EGR1, NCAM1, SYP
10hematoxylin4511.2CALB2, NKX2-1, NCAM1, SYP, CHGA, INHA
11ribonucleic acid4511.2FOLH1, EGR1, NKX2-1, CHGA, INHA, KIT
12thymidine45 2412.2CALB2, FOLH1, GAST, EGR1, KIT, PTHLH
13norepinephrine45 11 2413.1CALCA, GAST, EGR1, SYP, CHGA, PTHLH
14serine4511.1TMPRSS2, CXCR2, SYP, NCAM1, NKX2-1, FOLH1
15dopamine45 29 11 2414.1CALB2, GAST, EGR1, NCAM1, CHGA, ENO2
165-hydroxytryptamine4511.1CALCA, CALB2, GAST, SYP, CHGA, ENO2
17cisplatin45 50 60 1114.1GAST, EGR1, SYP, CHGA, PTHLH, ENO2
18gnrh4511.1GAST, EGR1, NKX2-1, NCAM1, CHGA, INHA
19gaba4511.1CALB2, GAST, NCAM1, SYP, CHGA, ENO2
20smcc4511.1NCAM1, SYP, CHGA, ENO2
21acth4511.1ENO2, INHA, CHGA, SYP, GAST
22octreotide45 60 29 1114.1CALCA, GAST, CHGA, PTHLH, ENO2
23dbc-amp4511.1EGR1, NCAM1, SYP, PTHLH, ENO2
24matrigel4511.1FOLH1, EGR1, NCAM1, CHGA, CXCR2, PTHLH
25forskolin45 50 1113.0CALCA, EGR1, NKX2-1, ENO2
26cyclic amp45 2412.0CALCA, EGR1, NKX2-1, SYP, CHGA, INHA
27glutamate4511.0FOLH1, GAST, NCAM1
28vincristine45 50 1113.0CALCA, NCAM1, KIT, PTHLH, TP53
29creatinine4511.0PTHLH, CHGA, SYP, NCAM1, GAST
30b 7234511.0CALB2, NKX2-1, SYP, CHGA
31histamine45 29 2413.0KIT, CHGA, SYP, NCAM1, GAST, CALCA
32estrogen4511.0CALB2
33dexamethasone45 50 29 1113.9ENO2, NKX2-1, EGR1
34bromodeoxyuridine4510.9GAST, NCAM1, CHGA, PTHLH, ENO2
35nmda45 2911.9FOLH1, EGR1, NCAM1, SYP
36guanine45 11 2412.9EGR1, CALCA
37111in-pentetreotide4510.9CALCA, SYP, CHGA
38paclitaxel45 50 1112.9TP53, CHGA, EGR1, CALB2
39gold4510.9CHGA, SYP, FOLH1
40formaldehyde45 2411.9ENO2, KIT, CHGA, SYP, NKX2-1
41ionomycin4510.9CALB2, EGR1, SYP, CHGA, PTHLH
42steroid4510.8CALB2, NKX2-1, SYP, INHA, PTHLH
43s 1004510.8SYP, CHGA, ENO2
44lactate4510.8CALCA, NCAM1, CHGA, KIT, PTHLH, ENO2
45mucicarmine4510.7CALB2, NKX2-1, SYP
46alanine4510.7GAST, NCAM1, INHA, CXCR2, PTHLH, ENO2
47mibg4510.7CALCA, CHGA, ENO2
48silver4510.6ENO2, CHGA, SYP, CALB2
49amine4510.5GAST, SYP, CHGA, ENO2
505-hydroxyindoleacetic acid45 2411.3ENO2, CHGA, GAST

GO Terms for genes affiliated with Small Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TMPRSS2, PTHLH, INHA, CHGA, NCAM1, GAST

Biological processes related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oligodendrocyte differentiationGO:04870910.5NKX2-1, EGR1

Molecular functions related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6PTHLH, INHA, GAST, CALCA

Products for genes affiliated with Small Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet