MCID: SML001
MIFTS: 64

Small Cell Carcinoma malady

Cancer diseases category

Summaries for Small Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

MalaCards: Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to lung small cell carcinoma and bladder carcinoma. An important gene associated with Small Cell Carcinoma is SYP (synaptophysin), and among its related pathways is Neuroscience. The drugs cisplatin and teniposide and the compounds testosterone and vegf have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and cervix, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology:8 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

Aliases & Classifications for Small Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

small cell carcinoma 8 10
small cell carcinoma, intermediate cell 8 60
small cell carcinoma - intermediate cell 8
intermediate cell small cell carcinoma 8
carcinoma, small cell 60


External Ids:

Disease Ontology8 DOID:0050685
SNOMED-CT56 5958006, 189557009
NCIt39 C4099

Related Diseases for Small Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

small cell carcinoma Large Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1lung small cell carcinoma31.6KIT, CXCR2, INHA, CHGA, SYP, NCAM1
2bladder carcinoma31.3TP53
3prostate small cell carcinoma31.3INA
4ovarian small cell carcinoma31.2TTF1
5non-small cell lung carcinoma31.2NKX2-1, NCAM1, SYP, CHGA, ENO2, TP53
6neuroendocrine carcinoma31.1ENO2, KIT, CHGA, SYP, NCAM1, NKX2-1
7squamous cell carcinoma31.0CALB2, EGR1, NKX2-1, SYP, CHGA, INHA
8adenocarcinoma31.0CALB2, FOLH1, GAST, TP53, ENO2, PTHLH
9merkel cell carcinoma30.9NKX2-1, NCAM1, SYP, CHGA, KIT, ENO2
10large cell carcinoma30.9NKX2-1, SYP, CHGA, PTHLH, ENO2
11esophagitis30.8GAST
12thyroiditis30.8CALCA
13lung cancer30.7EGR1, NKX2-1, NCAM1, CHGA, PTHLH, ENO2
14hypercalcemia30.5CALCA, GAST, CHGA, PTHLH
15cushing's syndrome30.5CALCA, SYP, CHGA, INHA
16neuroendocrine tumor30.4CALCA, GAST, NKX2-1, NCAM1, SYP, CHGA
17endometrial carcinoma30.4CALB2, NKX2-1, INHA, TP53
18neuropathy30.4CALCA
19transitional cell carcinoma30.3CALB2, FOLH1, ENO2, TP53
20ulcerative colitis30.3TP53
21prostate cancer30.2FOLH1, EGR1, CHGA, INHA, PTHLH, ENO2
22rhabdomyosarcoma30.2TP53, ENO2, INHA, NCAM1, CALB2
23malignant mesothelioma30.2CALB2, NKX2-1
24adenoma30.0TP53, ENO2, INHA, CHGA, SYP, NKX2-1
25melanoma30.0CALB2, FOLH1, EGR1, NKX2-1, INHA, CXCR2
26astrocytoma30.0EGR1, NCAM1, SYP, INHA, INA, CXCR2
27breast cancer30.0FOLH1, EGR1, NKX2-1, SYP, CHGA, PTHLH
28sarcoma30.0CALB2, FOLH1, KIT, ENO2, TP53
29meningioma30.0CALB2, NCAM1, SYP, INHA
30pancreatic cancer30.0TP53, PTHLH, CXCR2, CHGA, GAST
31tubular adenocarcinoma30.0NCAM1, SYP, CHGA, ENO2
32hepatocellular carcinoma30.0TP53, CXCR2, NKX2-1, EGR1
33glioblastoma multiforme30.0TP53, KIT, CXCR2, NCAM1, EGR1
34ovarian cancer30.0TP53, INHA, CALB2
35pulmonary blastoma30.0NKX2-1
36adenosquamous carcinoma30.0NKX2-1, CHGA, PTHLH
37vipoma30.0CHGA, GAST
38benign mesothelioma30.0CALB2, NKX2-1, TP53
39achalasia30.0GAST
40rheumatoid arthritis30.0CXCR2, EGR1
41retinoblastoma30.0SYP, ENO2, TP53
42arthritis30.0CXCR2, CALCA
43ischemia30.0NCAM1, EGR1
44cholangiocarcinoma30.0TP53, NCAM1
45brain cancer30.0SYP, TP53
46stomach cancer30.0TP53, CXCR2, CHGA, GAST
47leukemia30.0EGR1, NCAM1, KIT, TP53
48prostatitis10.9
49esophagus small cell carcinoma10.8
50cervix small cell carcinoma10.8

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to small cell carcinoma

Clinical Features for Small Cell Carcinoma

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Drugs & Therapeutics for Small Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Small Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma

Search NIH Clinical Center for Small Cell Carcinoma

Search CenterWatch for Small Cell Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Small Cell Carcinoma

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Anatomical Context for Small Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Small Cell Carcinoma:

32
Lung, Prostate, Cervix, Breast, Endothelial, Ovary, Lymph node, Thyroid, Brain, Liver, Kidney, Colon, Bone, Pancreas, Small intestine, Bone marrow, Testes, Salivary gland, Pituitary, B cells, Testis, T cells, Skin, Adrenal gland, Skeletal muscle, Tongue, Bronchial epithelium, Tonsil, Monocytes, Myeloid, Cerebellum, Thymus, Trachea, Appendix, Heart

Animal Models for Small Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Small Cell Carcinoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2TP53, CALCA, CALB2, FOLH1, EGR1, NKX2-1
2MP:000538511.2CALCA, FOLH1, EGR1, NEK8, NKX2-1, CHGA
3MP:001076811.1NKX2-1, NEK8, EGR1, GAST, CALCA, NCAM1
4MP:000538611.1CALCA, CALB2, FOLH1, EGR1, NEK8, NKX2-1
5MP:000200611.0CALCA, GAST, EGR1, NKX2-1, INHA, CXCR2
6MP:000538810.9EGR1, NEK8, CXCR2, PTHLH, ENO2, TP53
7MP:000537610.9CALCA, FOLH1, GAST, EGR1, NEK8, CNN1
8MP:000537810.9NEK8, NKX2-1, NCAM1, CHGA, INHA, CXCR2
9MP:000537910.8GAST, EGR1, INHA, KIT, TP53
10MP:000539010.7NKX2-1, CNN1, INHA, PTHLH
11MP:000287310.7CALCA, CALB2, SYP, INHA, INA, KIT
12MP:000536710.6CXCR2, CHGA, NEK8
13MP:000538910.3EGR1, INHA, CXCR2, TP53

Publications for Small Cell Carcinoma

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50PubMed
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Articles related to Small Cell Carcinoma:

(show top 50)    (show all 2078)
idTitleAuthorsYear
1
Long-term Survival of a Patient with Extensive Small Cell Carcinoma of Unknown Primary Etiology Complicated by Nephrotic Syndrome. (24429459)
2014
2
Allelic imbalance in 1p, 7q, 9p, 11p, 12q and 16q regions in non-small cell lung carcinoma and its clinical association: a pilot study. (24091944)
2013
3
Clinical management of small-cell carcinoma of the urinary tract: a 10-year single-center's experience. (23146567)
2013
4
Determination of safe margin in the surgical pathologic specimens of non-small cell carcinoma of the lung. (23781567)
2013
5
Small-cell carcinoma of the lung detected by CT screening: stage distribution and curability. (22189270)
2012
6
Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma. (22236865)
2012
7
IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver. (22495359)
2012
8
Clinical utility of circulating tumor cells in non-small-cell lung carcinoma: are we there yet? (23050104)
2012
9
Small cell carcinoma ex-pleomorphic adenoma of the parotid gland. (22736150)
2012
10
Two cases of primary small cell carcinoma of the breast showing non-mass-like pattern on diagnostic imaging and histopathology. (22968627)
2012
11
Treatment trends and outcomes of small-cell carcinoma of the bladder: in regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20). (22385714)
2012
12
Impact of prophylactic cranial irradiation timing on brain relapse rates in patients with stage IIIB non-small-cell lung carcinoma treated with two different chemoradiotherapy regimens. (22172902)
2012
13
Primary endometrial small cell carcinoma. (22185556)
2012
14
Classification of non-small cell lung carcinoma in transthoracic needle specimens using microRNA expression profiling. (21622546)
2011
15
Small-cell carcinoma of the gallbladder: report of a case and literature review. (22368737)
2011
16
Clinical analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma. (21771344)
2011
17
Small atypical cervical nodes detected on sonography in patients with squamous cell carcinoma of the head and neck: probability of metastasis. (20375372)
2010
18
Metastatic small cell carcinoma lung presenting as a breast mass: cytologic findings. (20071796)
2010
19
Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report. (19715991)
2009
20
Successful treatment for advanced small cell carcinoma of the ovary. (18293381)
2008
21
Small cell carcinoma of the uterine cervix metastasizing to the bone marrow: a case report. (18840183)
2008
22
Computerized morphometric analysis of microvasculature in non-small cell lung carcinoma. (17560614)
2008
23
Small cell carcinoma of the gallbladder successfully treated by surgery and adjuvant chemotherapy. (18380037)
2008
24
Endocrine paraneoplastic syndromes in small cell lung carcinoma. Two case reports. (17918299)
2007
25
The pathology of extrapulmonary small cell carcinoma. (17270663)
2007
26
Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. (18091382)
2007
27
Small cell carcinoma of the nasopharynx. (17364353)
2007
28
Primary small cell carcinoma of the pancreas with an unusual sonographic appearance. (17206725)
2007
29
Long term disease-free survival resulting from combined modality management of patients presenting with oligometastatic, non-small cell lung carcinoma (NSCLC). (17050016)
2006
30
Value of CK14 and CD56 immunostaining in distinguishing small cell carcinoma from squamous cell carcinoma of the esophagus. (17017394)
2006
31
Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by small cell lung carcinoma. (16258223)
2005
32
Preclinical anti-tumor activity of XR5944 in combination with carboplatin or doxorubicin in non-small-cell lung carcinoma. (16162971)
2005
33
Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma". (16325513)
2005
34
Non-CpG cytosine methylation of p53 exon 5 in non-small cell lung carcinoma. (16125822)
2005
35
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. (16287968)
2005
36
Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix. (15044919)
2004
37
Multivariate analysis of factors predictive of brain metastases in localised non-small cell lung carcinoma. (15301872)
2004
38
The role of epidermal growth factor receptor in advanced non-small cell lung carcinoma. (14649327)
2003
39
Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. (11768610)
2001
40
p53 Expression in non-small cell and small cell lung carcinomas: relationship with proliferating cell nuclear antigen and cigarette smoking. (17264600)
2001
41
Cytology of ascitic fluid in a patient with gastric small cell carcinoma. (11041808)
2000
42
Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small-cell lung carcinoma cells. (10528922)
1999
43
Chromogranin A gene expression in non-small cell lung carcinomas. (9924430)
1998
44
Small cell carcinoma of the lung presenting as chylous ascites: a unique case. (9646203)
1997
45
Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma. (8392984)
1993
46
Immunohistochemical detection of cluster 1 small cell lung cancer antigen and chromogranin A in lung carcinomas. (1315401)
1992
47
Small cell undifferentiated carcinoma of the pancreas. Report of a patient with tumor marker studies. (1325274)
1992
48
Circulating arginine-vasopressin, calcitonin, carcinoembryonic antigen, neuron-specific enolase, and beta-2 microglobulin fluctuations during combined modality induction therapy for small-cell bronchogenic carcinoma. Association of postchemotherapy AVP surge with high tumor response rate and durable remission. (1648782)
1991
49
Autoantibodies bind solubilized calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome. (2557495)
1989
50
Continuous infusion of etoposide, bolus administration of cisplatin, and simultaneous radiation therapy in previously treated patients with small cell bronchogenic carcinoma. (2832766)
1988

Genetic Variations for Small Cell Carcinoma

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Expression for genes affiliated with Small Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for genes affiliated with Small Cell Carcinoma

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4Cell Signaling Technology
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Pathways related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7ENO2, SYP, NCAM1, NKX2-1, EGR1

Compounds for genes affiliated with Small Cell Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2414.4CALB2, CALCA, FOLH1, NCAM1, GAST, SYP
2vegf4411.4SYP, CALCA, GAST, EGR1, NCAM1, FOLH1
3tyrosine4411.3NCAM1, NKX2-1, EGR1, GAST, CALB2, PTHLH
4progesterone44 59 28 11 2415.3SYP, NCAM1, INHA, KIT, PTHLH, ENO2
5retinoic acid44 2412.3ENO2, CHGA, INA, CXCR2, KIT, NCAM1
6paraffin4411.3PTHLH, CALB2, NCAM1, TP53, KIT, ENO2
7calcium44 49 11 2414.3CALCA, CALB2, ENO2, CXCR2, CHGA, KIT
8nitric oxide44 11 2413.3CHGA, SYP, EGR1, CALB2, CALCA, CXCR2
9acetylcholine44 49 28 11 2415.3PTHLH, CHGA, NCAM1, SYP, EGR1, GAST
10hematoxylin4411.2CALB2, KIT, CHGA, INHA, ENO2, SYP
11ribonucleic acid4411.2FOLH1, ENO2, PTHLH, INHA, CHGA, NKX2-1
12thymidine44 2412.2EGR1, FOLH1, KIT, PTHLH, ENO2, TP53
13norepinephrine44 11 2413.1CALCA, GAST, EGR1, SYP, CHGA, PTHLH
14serine4411.1CXCR2, TMPRSS2, NCAM1, FOLH1, SYP, NKX2-1
15dopamine44 28 11 2414.1ENO2, CHGA, NCAM1, CALB2, GAST, EGR1
165-hydroxytryptamine4411.1CALCA, CALB2, GAST, SYP, CHGA, ENO2
17cisplatin44 49 59 1114.1SYP, TP53, ENO2, EGR1, GAST, CHGA
18gnrh4411.1EGR1, INHA, CHGA, NCAM1, NKX2-1, GAST
19gaba4411.1ENO2, CHGA, SYP, NCAM1, GAST, CALB2
20smcc4411.1NCAM1, SYP, CHGA, ENO2
21acth4411.1GAST, SYP, CHGA, INHA, ENO2
22octreotide44 59 28 1114.1ENO2, PTHLH, CHGA, GAST, CALCA
23dbc-amp4411.1NCAM1, EGR1, ENO2, PTHLH, SYP
24matrigel4411.1EGR1, PTHLH, NCAM1, CHGA, FOLH1, CXCR2
25forskolin44 49 1113.0EGR1, ENO2, NKX2-1, CALCA
26cyclic amp44 2412.0INHA, PTHLH, CHGA, SYP, EGR1, CALCA
27glutamate4411.0FOLH1, NCAM1, GAST
28vincristine44 49 1113.0PTHLH, NCAM1, CALCA, KIT, TP53
29creatinine4411.0GAST, NCAM1, CHGA, PTHLH, SYP
30b 7234411.0CHGA, CALB2, NKX2-1, SYP
31histamine44 28 2413.0CALCA, GAST, NCAM1, SYP, CHGA, KIT
32estrogen4411.0CALB2
33dexamethasone44 49 28 1113.9EGR1, NKX2-1, ENO2
34bromodeoxyuridine4410.9PTHLH, CHGA, GAST, NCAM1, ENO2
35nmda44 2811.9SYP, NCAM1, FOLH1, EGR1
36guanine44 11 2412.9EGR1, CALCA
37111in-pentetreotide4410.9CALCA, SYP, CHGA
38paclitaxel44 49 1112.9TP53, CHGA, CALB2, EGR1
39gold4410.9SYP, CHGA, FOLH1
40formaldehyde44 2411.9NKX2-1, SYP, CHGA, KIT, ENO2
41ionomycin4410.9CHGA, SYP, EGR1, CALB2, PTHLH
42steroid4410.8NKX2-1, PTHLH, SYP, INHA, CALB2
43s 1004410.8ENO2, CHGA, SYP
44lactate4410.8PTHLH, ENO2, CALCA, KIT, CHGA, NCAM1
45mucicarmine4410.7NKX2-1, CALB2, SYP
46alanine4410.7ENO2, FOLH1, GAST, INHA, CXCR2, PTHLH
47mibg4410.7ENO2, CHGA, CALCA
48silver4410.6CALB2, SYP, CHGA, ENO2
49amine4410.5ENO2, CHGA, SYP, GAST
505-hydroxyindoleacetic acid44 2411.3GAST, CHGA, ENO2

GO Terms for genes affiliated with Small Cell Carcinoma

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16Gene Ontology
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Cellular components related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.7TMPRSS2, PTHLH, INHA, CHGA, NCAM1, GAST

Biological processes related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oligodendrocyte differentiationGO:04870910.5NKX2-1, EGR1

Molecular functions related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.6PTHLH, INHA, GAST, CALCA

Products for genes affiliated with Small Cell Carcinoma

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  • Antibodies
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Sources for Small Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet