MCID: SML001
MIFTS: 64

Small Cell Carcinoma malady

Cancer diseases, Skin diseases, Rare diseases categories
Download this MalaCard

Summaries for Small Cell Carcinoma

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

MalaCards: Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to ovarian small cell carcinoma and merkel cell carcinoma. An important gene associated with Small Cell Carcinoma is SYP (synaptophysin), and among its related pathways is Neuroscience. The drugs cisplatin and cisplatin pwdr and the compounds b 723 and 111in-pentetreotide have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and cervix, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Disease Ontology:8 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

Aliases & Classifications for Small Cell Carcinoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

small cell carcinoma 8 10
small cell carcinoma, intermediate cell 8 62
small cell carcinoma - intermediate cell 8
intermediate cell small cell carcinoma 8
carcinoma, small cell 62


External Ids:

Disease Ontology8 DOID:0050685
SNOMED-CT58 5958006, 189557009
NCIt40 C4099

Related Diseases for Small Cell Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Basal Cell Carcinoma family:

Large Cell Carcinoma small cell carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian small cell carcinoma31.4TTF1
2merkel cell carcinoma30.9CHGA, ENO2, SYP, NKX2-1
3neuroendocrine carcinoma30.8SYP, NKX2-1, CALCA, ENO2, KIT, NCAM1
4adenocarcinoma30.7ENO2, FOLH1, NKX2-1, INHA, PTHLH, TP53
5hypercalcemia30.7PTHLH, CHGA, CALCA
6lung cancer30.6PTHLH, TP53, CHGA, ENO2, NCAM1, NKX2-1
7cushing's syndrome30.5CALCA, SYP, CHGA, INHA
8large cell carcinoma30.5NKX2-1, SYP, PTHLH, ENO2, CHGA
9lung small cell carcinoma30.4CALCA, SYP, INHA, CHGA, TP53, PTHLH
10adenoid cystic carcinoma30.3KIT, NCAM1
11teratoma30.3NKX2-1, KIT, ENO2
12transitional cell carcinoma30.3FOLH1, ENO2, TP53
13rhabdomyosarcoma30.2NCAM1, INHA, ENO2, TP53
14pulmonary blastoma30.2NKX2-1
15vipoma30.2CHGA
16neuroendocrine tumor30.1CALCA, CHGA
17tubular adenocarcinoma30.1CHGA, NCAM1, ENO2, SYP
18adenosquamous carcinoma30.1PTHLH, NKX2-1, CHGA
19meningioma30.1NCAM1, SYP, INHA
20pancreatic cancer30.0PTHLH, CHGA, SYP, INHA
21astrocytoma30.0TP53, INHA, NCAM1, SYP
22non-small cell lung carcinoma30.0NKX2-1, NCAM1, SYP, ENO2, CHGA, TP53
23prostate cancer29.9FOLH1, INHA, PTHLH, CHGA, ENO2
24adenoma29.8TP53, CHGA, SYP, NKX2-1, ENO2, CALCA
25melanoma29.8ENO2, KIT, NKX2-1, FOLH1, TP53, INHA
26breast cancer29.7CALCA, KIT, NCAM1, FOLH1, PTHLH, INHA
27prostatitis10.9
28small cell carcinoma of the bladder10.7
29prostate small cell carcinoma10.7
30gastric small cell carcinoma10.7
31esophagitis10.6
32thyroiditis10.6
33large cell neuroendocrine carcinoma10.6
34pancreatitis10.5
35endometrial small cell carcinoma10.4
36laryngeal small cell carcinoma10.4
37lambert-eaton myasthenic syndrome10.4
38gallbladder small cell carcinoma10.4
39acute pancreatitis10.4
40ampulla of vater small cell carcinoma10.3
41thymus small cell carcinoma10.3
42ureter small cell carcinoma10.3
43neuronitis10.3
44cervix small cell carcinoma10.3
45colon small cell carcinoma10.3
46hypercalcemic type ovarian small cell carcinoma10.3
47cervicitis10.3
48laryngitis10.3
49neuropathy10.3
50syndrome of inappropriate antidiuretic hormone10.3

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to small cell carcinoma

Symptoms for Small Cell Carcinoma

About this section

Drugs & Therapeutics for Small Cell Carcinoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma

Search NIH Clinical Center for Small Cell Carcinoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Small Cell Carcinoma

About this section

Anatomical Context for Small Cell Carcinoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Small Cell Carcinoma:

33
Lung, Prostate, Cervix, Ovary, Breast, Thyroid, Kidney, Liver, Brain, Lymph node, Pancreas, Salivary gland, Colon, Bone, Bone marrow, Tonsil, Pituitary, Skin, Adrenal gland, Skeletal muscle, Appendix, Trachea, Tongue, B cells, Monocytes, Myeloid, Cerebellum, Heart, Testes, Bronchial epithelium

Animal Models for Small Cell Carcinoma or affiliated genes

About this section
Sources:
37MGI
See all sources

Publications for Small Cell Carcinoma

About this section
Sources:
52PubMed
See all sources

Articles related to Small Cell Carcinoma:

(show top 50)    (show all 733)
idTitleAuthorsYear
1
Small cell carcinoma of the urinary bladder and prostate: Cytological analyses of four cases with emphasis on the usefulness of cytological examination. (24396449)
2014
2
Small cell carcinoma of the head and neck: report of three cases. (23927815)
2013
3
Primary small cell carcinoma of kidney after renal transplantation: a case report and literature review. (24255587)
2013
4
Merkel cell polyomavirus and extrapulmonary small cell carcinoma. (24137462)
2013
5
Clinical impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of small cell carcinoma of the prostate. (23218515)
2013
6
Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type. (23459374)
2013
7
Small cell carcinoma of the colon arising in a carcinoid tumor. (23564820)
2013
8
Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures. (22316327)
2012
9
Small-cell carcinoma of the lung detected by CT screening: stage distribution and curability. (22189270)
2012
10
New treatment trends in small cell carcinoma of the urinary bladder. (23335548)
2012
11
Colorectal small cell carcinoma in ulcerative colitis with identical rare p53 gene mutation to associated adenocarcinoma and dysplasia. (22261536)
2012
12
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. (21210145)
2011
13
Pure small cell carcinoma of the prostate: a case report and literature review. (21475596)
2011
14
Cytokeratin (CK7 and CK20) switching in the natural history of pulmonary small cell carcinoma: an interesting but unpublished phenomenon. (21248319)
2011
15
Back pain and leg complaints that revealed non-small cell carcinoma: a case study. (22014908)
2011
16
Long-term survival and improved quality of life after chemoradiotherapy to treat esophageal small cell carcinoma: a report of two cases. (22086689)
2011
17
Phase II study of weekly irinotecan plus cisplatin in patients with previously untreated extensive-stage extrapulmonary small cell carcinoma. (21734424)
2011
18
Small cell carcinoma of the urinary bladder. (20017108)
2010
19
A complete response in small cell carcinoma of the esophagus treated by s-1/cisplatin combined chemotherapy and radiotherapy. (20437111)
2010
20
Sequential treatment of superior vena cava syndrome caused by of non-small cell carcinoma lung cancer (NSCLC) with vascular stenting and iodine-125 implantation. (19645521)
2009
21
Small cell carcinoma of the uterine cervix: clinicopathologic study of 20 cases in a single center. (19899411)
2009
22
Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report. (19715991)
2009
23
Analysis of ThinPrep cytology in establishing the diagnosis of small cell carcinoma of lung. (19347830)
2009
24
Metastasis to eyelid as initial presentation of non-small cell carcinoma. (19966662)
2009
25
Successful treatment for advanced small cell carcinoma of the ovary. (18293381)
2008
26
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. (18580310)
2008
27
A rare case of ectopic adrenocorticotropic hormone syndrome in small cell carcinoma of the vagina: a case report. (18369310)
2008
28
Small cell carcinoma of the breast. (17270668)
2007
29
The prognostic value of carcinoembryonic antigen in T1N1M0 and T2N1M0 non-small cell carcinoma of the lung. (17643308)
2007
30
Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. (17727473)
2007
31
Small cell carcinoma of the urinary bladder--histogenesis, genetics, diagnosis, biomarkers, treatment, and prognosis. (17536302)
2007
32
Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. (17805055)
2007
33
Use of dynamic contrast-enhanced magnetic resonance imaging for differentiating between aggressive rectal tumours: two cases with small cell carcinoma and malignant melanoma. (17148806)
2006
34
Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents: a prognostically unfavorable but curable disease. (16998935)
2006
35
Gallbladder small cell carcinoma Xenograft established by serial transplantation in nude mice. (16475682)
2006
36
Combined small cell carcinoma with pulmonary blastoma and adenocarcinoma: case report and clonality analysis. (17046168)
2006
37
Metastasis of small cell carcinoma of lung into an ovarian mucinous neoplasm: immunohistochemistry as a useful ancillary technique for diagnosis and classification of rare tumors. (15722802)
2005
38
Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon. (15383629)
2004
39
Small cell carcinoma of the prostate expressing prostate-specific antigen and showing syndrome of inappropriate secretion of antidiuretic hormone: an autopsy case report. (14629757)
2003
40
Cerebrospinal fluid gastrin releasing peptide in the diagnosis of leptomeningeal metastases from small cell carcinoma. (11391593)
2001
41
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. (11175640)
2001
42
Ovarian small cell carcinoma: a rare neoplasm in a 15-year-old female. (10888454)
2000
43
Small cell carcinoma of the breast: a clinicopathologic and immunohistochemical study of nine patients. (10976697)
2000
44
Small cell carcinoma of the prostate: a case report]. (9783201)
1998
45
Ovarian small cell carcinoma with K-ras mutation: a case report with genetic analysis. (8543315)
1996
46
Neurofilament immunoreactivity in Merkel-cell tumors: a differentiating feature from small-cell carcinoma. (7678934)
1993
47
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. (1660144)
1991
48
Neuroendocrine differentiation in mA1llerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed mA1llerian tumor containing small-cell carcinoma. (3020961)
1986
49
Physalaemin-like immunoreactivity from human lung small cell carcinoma: isocratic reversed-phase HPLC analysis of the chemically modified peptide. (2999922)
1985
50
Human lung small-cell carcinoma contains bombesin. (6285381)
1982

Variations for Small Cell Carcinoma

About this section

Expression for genes affiliated with Small Cell Carcinoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for genes affiliated with Small Cell Carcinoma

About this section
Sources:
50PathCards, 5Cell Signaling Technology
See all sources

Pathways related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7ENO2, NCAM1, NKX2-1, SYP

Compounds for genes affiliated with Small Cell Carcinoma

About this section
Sources:
45Novoseek, 29IUPHAR, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
See all sources

Compounds related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1b 723459.8CHGA, SYP, NKX2-1
2111in-pentetreotide459.7CALCA, SYP, CHGA
3s 100459.5CHGA, ENO2, SYP
4l-amino acid459.4ENO2, SYP, CHGA
5gnrh459.3INHA, NCAM1, CHGA, NKX2-1
6smcc459.2NCAM1, SYP, ENO2, CHGA
7gold459.1SYP, KIT, NCAM1, CHGA, FOLH1
8matrigel459.1CHGA, PTHLH, FOLH1, NCAM1
9mibg459.1CHGA, CALCA, ENO2
10dbc-amp459.1ENO2, NCAM1, SYP, PTHLH
11estracyt459.1ENO2, CHGA
12bromodeoxyuridine459.0PTHLH, CHGA, NCAM1, ENO2
13gaba459.0SYP, CHGA, ENO2, NCAM1
14histamine45 29 2410.9CHGA, NCAM1, KIT, SYP, CALCA
15vincristine45 51 1110.9PTHLH, KIT, TP53, CALCA, NCAM1
16etoposide45 51 61 1111.8CHGA, TP53, SYP, ENO2
175-hydroxytryptamine458.8CALCA, CHGA, ENO2, SYP
18formaldehyde45 249.8SYP, CHGA, NKX2-1, ENO2, KIT
19octreotide45 61 29 1111.8PTHLH, CHGA, CALCA, ENO2
20docetaxel45 51 61 1111.7TP53, KIT, FOLH1, ENO2
21spec-t458.7ENO2, CALCA, FOLH1
22steroid458.7SYP, NKX2-1, INHA, PTHLH, CHGA, KIT
23oligonucleotide458.7CHGA, NKX2-1, KIT, INHA, TP53
24glycogen45 249.6ENO2, KIT, SYP, CHGA, PTHLH
25cisplatin45 51 61 1111.6ENO2, PTHLH, SYP, CHGA, TP53
26nmda45 299.6ENO2, SYP, FOLH1, NCAM1
27guanine45 24 1110.6TP53, CHGA, CALCA, ENO2, SYP
28cyclic amp45 249.5NKX2-1, CALCA, SYP, INHA, PTHLH, CHGA
29norepinephrine45 24 1110.5PTHLH, ENO2, CALCA, SYP, CHGA
30dopamine45 29 24 1111.5SYP, CALCA, ENO2, CHGA, NCAM1
31acth458.4CALCA, INHA, CHGA, ENO2, SYP
32dexamethasone45 51 29 1111.4PTHLH, CHGA, SYP, ENO2, NCAM1, NKX2-1
33thymidine45 249.3KIT, ENO2, TP53, PTHLH, FOLH1
34acetylcholine45 51 29 24 1112.2SYP, NCAM1, PTHLH, ENO2, CALCA, CHGA
35creatinine458.2NCAM1, CHGA, SYP, CALCA, PTHLH, ENO2
36lactate458.1ENO2, NCAM1, CALCA, CHGA, KIT, PTHLH
37serine458.0CHGA, NCAM1, SYP, FOLH1, KIT, PTHLH
38hematoxylin458.0ENO2, KIT, NCAM1, NKX2-1, SYP, CHGA
39glutamate458.0CHGA, ENO2, NCAM1, FOLH1, SYP, CALCA
40nitric oxide45 24 119.8SYP, PTHLH, NCAM1, ENO2, KIT, CHGA
41retinoic acid45 248.8TP53, KIT, PTHLH, CHGA, ENO2, SYP
42forskolin45 51 119.7ENO2, CALCA, INHA, PTHLH, CHGA, NKX2-1
43ribonucleic acid457.7CHGA, FOLH1, INHA, ENO2, NKX2-1, KIT
44tyrosine457.6NKX2-1, ENO2, NCAM1, INHA, PTHLH, CHGA
45paraffin457.3SYP, KIT, ENO2, NCAM1, NKX2-1, PTHLH
46progesterone45 29 61 24 1111.3ENO2, TP53, KIT, NCAM1, NKX2-1, SYP
47calcium45 51 24 1110.3KIT, PTHLH, ENO2, NCAM1, CALCA, SYP
48vegf457.0TP53, SYP, CHGA, FOLH1, CALCA, NCAM1
49testosterone45 61 24 119.9ENO2, KIT, FOLH1, NCAM1, CALCA, SYP
50estrogen456.7KIT, NCAM1, NKX2-1, CALCA, SYP, INHA

GO Terms for genes affiliated with Small Cell Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1NCAM1, CHGA, PTHLH, INHA
2photoreceptor inner segmentGO:0019178.9ENO2, INHA

Biological processes related to Small Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1endoderm developmentGO:0074929.9NKX2-1, PTHLH
2negative regulation of DNA replicationGO:0081569.8TP53, TTF1
3ovarian follicle developmentGO:0015419.6KIT, INHA
4positive regulation of cAMP biosynthetic processGO:0308199.5PTHLH, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.4CALCA, PTHLH
6erythrocyte differentiationGO:0302189.3KIT, INHA
7cell-cell signalingGO:0072679.1CALCA, PTHLH, INHA

Molecular functions related to Small Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.0NCAM1, CALCA, SYP, TP53
2hormone activityGO:0051798.7CALCA, PTHLH, INHA

Products for genes affiliated with Small Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Cell Carcinoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet