MCID: SML001
MIFTS: 55

Small Cell Carcinoma

Categories: Cancer diseases, Genetic diseases, Skin diseases, Rare diseases

Aliases & Classifications for Small Cell Carcinoma

MalaCards integrated aliases for Small Cell Carcinoma:

Name: Small Cell Carcinoma 12 14
Small Cell Carcinoma, Intermediate Cell 12 69
Small Cell Carcinoma - Intermediate Cell 12
Intermediate Cell Small Cell Carcinoma 12
Small Cell Carcinoma of Lung 69
Carcinoma, Small Cell 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050685
NCIt 47 C4099
SNOMED-CT 64 189557009 5958006
UMLS 69 C0334239

Summaries for Small Cell Carcinoma

Disease Ontology : 12 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

MalaCards based summary : Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to lung occult small cell carcinoma and prostate small cell carcinoma. An important gene associated with Small Cell Carcinoma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Downstream signaling events of B Cell Receptor (BCR) and Endometrial cancer. The drugs Cetuximab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and brain, and related phenotypes are Decreased viability in esophageal squamous lineage and cellular

Wikipedia : 72 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

Related Diseases for Small Cell Carcinoma

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 6
Basal Cell Carcinoma 5 Basal Cell Carcinoma 4
Basal Cell Carcinoma 7 Cell Type Cancer
Cell Type Benign Neoplasm Basal Cell Carcinoma
Large Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
id Related Disease Score Top Affiliating Genes
1 lung occult small cell carcinoma 34.1 CHGA KRT20
2 prostate small cell carcinoma 33.7 KLK3 KRT20 SYP
3 ampulla of vater small cell carcinoma 33.5 CHGA ENO2 GRP SYP
4 thymus small cell carcinoma 32.1 ENO2 KIT NCAM1 PDGFRA PTPRC SYP
5 pneumonia 30.0 CHGA ENO2 NCAM1 SYP
6 prostate cancer 28.9 CHGA EGFR ENO2 GRP KLK3 PTEN
7 lung cancer 26.3 ASCL1 CHGA EGFR ENO2 GRP KIT
8 ovarian small cell carcinoma 12.3
9 lung combined type small cell carcinoma 12.2
10 small cell carcinoma of the bladder 12.1
11 gastric small cell carcinoma 12.1
12 laryngeal small cell carcinoma 12.1
13 endometrial small cell carcinoma 12.1
14 gallbladder small cell carcinoma 12.1
15 colon small cell carcinoma 12.0
16 hypercalcemic type ovarian small cell carcinoma 12.0
17 cervix small cell carcinoma 12.0
18 ureter small cell carcinoma 12.0
19 bartholin's gland small cell carcinoma 11.9
20 esophagus small cell carcinoma 11.9
21 pulmonary type ovarian small cell carcinoma 11.9
22 small cell cancer of the lung, somatic 11.1
23 merkel cell carcinoma 11.1
24 2q31.1 microdeletion syndrome 11.0 ENO2 SYP
25 malignant ovarian mixed epithelial neoplasm 10.9 CHGA SYP
26 paranasal sinus cancer 10.9 ENO2 SYP
27 lung large cell carcinoma 10.9
28 supratentorial primitive neuroectodermal tumor 10.8 CHGA ENO2
29 spinal cord ependymoma 10.8 CHGA SYP
30 arteriosclerosis obliterans 10.8 ENO2 NCAM1
31 situs inversus totalis with cystic dysplasia of kidneys and pancreas 10.8 ENO2 SYP
32 periosteal osteogenic sarcoma 10.8 KRT20 NKX2-1
33 signet ring cell intrahepatic cholangiocarcinoma 10.8 CHGA SYP
34 sensory system cancer 10.8 CHGA KRT20
35 skin papilloma 10.8 ENO2 NKX2-1 SYP
36 childhood choriocarcinoma of the ovary 10.8 CHGA ENO2 SYP
37 osteoblastoma 10.8 CHGA ENO2 SYP
38 fibroepithelial polyp of urethra 10.8 CHGA KRT20
39 mature teratoma 10.8 ENO2 NKX2-1 SYP
40 mast cell neoplasm 10.7 CHGA ENO2 SYP
41 bronchus adenoma 10.7 ENO2 SYP
42 pleomorphic xanthoastrocytoma 10.7 CHGA ENO2 SYP
43 esophagus adenocarcinoma 10.7 CHGA NKX2-1 SYP
44 pituitary dwarfism with large sella turcica 10.7 CHGA ENO2 SYP
45 epidural abscess 10.7 CHGA ENO2 PTEN
46 nose disease 10.7 CHGA ENO2 SYP
47 pediatric ependymoma 10.7 CHGA ENO2 SYP
48 bladder benign neoplasm 10.7 CHGA ENO2 NKX2-1
49 basophilic carcinoma 10.7 CHGA SYP
50 calcific tendinitis 10.7 CHGA ENO2 SYP

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to Small Cell Carcinoma

Symptoms & Phenotypes for Small Cell Carcinoma

GenomeRNAi Phenotypes related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ASCL1 CHGA KIT KLK3 NKX2-1 PDGFRA

MGI Mouse Phenotypes related to Small Cell Carcinoma:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 ASCL1 EGFR ENO2 KIT NCAM1 NKX2-1
2 behavior/neurological MP:0005386 10.24 PDGFRA PTEN SYP TP53 ASCL1 ENO2
3 growth/size/body region MP:0005378 10.23 ASCL1 CHGA EGFR ENO2 KIT NKX2-1
4 endocrine/exocrine gland MP:0005379 10.22 ASCL1 CHGA EGFR KIT NKX2-1 PDGFRA
5 mortality/aging MP:0010768 10.21 ASCL1 CHGA EGFR KIT NCAM1 NKX2-1
6 nervous system MP:0003631 10.15 PDGFRA PTEN PTPRC SMARCA4 SYP TP53
7 digestive/alimentary MP:0005381 10.1 EGFR KIT NKX2-1 PDGFRA PTEN PTPRC
8 neoplasm MP:0002006 10.06 EGFR KIT NKX2-1 PDGFRA PTEN PTPRC
9 craniofacial MP:0005382 10.05 TP53 ASCL1 EGFR ENO2 KIT PDGFRA
10 normal MP:0002873 10 ASCL1 EGFR KIT NKX2-1 PDGFRA PTEN
11 no phenotypic analysis MP:0003012 9.87 ASCL1 EGFR KIT NKX2-1 PDGFRA PTPRC
12 pigmentation MP:0001186 9.63 ASCL1 EGFR KIT PDGFRA PTEN TP53
13 renal/urinary system MP:0005367 9.56 CHGA EGFR KIT PDGFRA PTEN PTPRC
14 respiratory system MP:0005388 9.36 ASCL1 EGFR ENO2 KIT NKX2-1 PDGFRA

Drugs & Therapeutics for Small Cell Carcinoma

Drugs for Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 458)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1 205923-56-4 56842117 2333
2
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
3
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Irinotecan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 97682-44-5, 100286-90-6 60838
6
Gefitinib Approved, Investigational Phase 4,Phase 1,Phase 2 184475-35-2 123631
7
Bupropion Approved Phase 4,Phase 3,Phase 2 34841-39-9, 34911-55-2 444
8
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
9
Nicotine Approved Phase 4,Phase 3,Phase 1 54-11-5 942 89594
10
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
11
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
12
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
13
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1 7689-03-4
14 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
18 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
19 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Mitomycins Phase 4
21 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
22 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
23 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
24 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
25 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Protein Kinase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
28 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 2
31 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 2
32 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
33 Dopamine Agents Phase 4,Phase 3,Phase 2
34 Dopamine Uptake Inhibitors Phase 4,Phase 3,Phase 2
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
37 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
38 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Central Nervous System Stimulants Phase 4,Phase 3,Phase 1
40 Cholinergic Agents Phase 4,Phase 3,Phase 1
41 Nicotinic Agonists Phase 4,Phase 3,Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
44
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
45
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
46
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
47
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
48
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
49
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
50
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1

Interventional clinical trials:

(show top 50) (show all 959)

id Name Status NCT ID Phase Drugs
1 Cetuximab Compared to Mitomycin-C and 5-Fluorouracil for Locally Advanced Squamous Cell Carcinomas of the Head and Neck Unknown status NCT02015650 Phase 4 Cetuximab;Mitomycin-C/ 5-Fluorouracil
2 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed NCT00666978 Phase 4 bupropion hydrochloride
3 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed NCT00365508 Phase 4 nicotine lozenge;nicotine patch
4 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
5 Irinotecan Plus Cisplatin Compared With Etoposide Plus Cisplatin for Extensive Stage Small-cell Lung Cancer Recruiting NCT02348450 Phase 4 Irinotecan;Etoposide;Cisplatin
6 VISmodegib for ORbital and Periocular Basal Cell Carcinoma Recruiting NCT02436408 Phase 4 Vismodegib
7 the Clinical Trial of Gefitinib(Non - Small Cell Lung Cancer) Not yet recruiting NCT03264794 Phase 4 Gefitinib Tab (CTTQ),First medication;Gefitinib Tab (CTTQ),From the 8th day of trial;Gefitinib tablets (Yi Ruisha),First medication;Gefitinib Tab 250 MG(CTTQ),From the 8th day of trial.
8 Increased Dose of Icotinib in Advanced None Small Cell Lung Cancer Patients After Routine Gefitinib Therapy Suspended NCT01720901 Phase 4 Icotinib
9 A Post Marketing Surveillance As Required By Philippine Food And Drug Administration Withdrawn NCT01781442 Phase 4 Temsirolimus
10 STAD-1 Small Cell Lung Cancer Toxicity Adjusted Dosing Study Unknown status NCT00526396 Phase 3 cisplatin;etoposide;cisplatin;etoposide
11 Trial of Belotecan/Cisplatin in Chemotherapy Naive Small Cell Lung Cancer Patient Unknown status NCT00826644 Phase 3 Belotecan/Cisplatin;Etoposide/Cisplatin
12 Combination Chemotherapy in Treating Patients Who Have Extensive-Stage Small Cell Lung Cancer Unknown status NCT00003696 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;paclitaxel
13 Combination Chemotherapy in Treating Patients With Extensive Stage Small Cell Lung Cancer Unknown status NCT00003606 Phase 3 cisplatin;cyclophosphamide;epirubicin hydrochloride;etoposide
14 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Small Cell Lung Cancer Unknown status NCT00002858 Phase 3 cisplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide
15 Chemotherapy Followed by Peripheral Stem Cell or Bone Marrow Transplant Compared With Chemotherapy Alone in Treating Patients With Small Cell Lung Cancer Unknown status NCT00011921 Phase 3 carboplatin;epirubicin hydrochloride;etoposide;etoposide phosphate;ifosfamide;paclitaxel
16 Study of Palifosfamide-tris in Combination With Carboplatin and Etoposide in Chemotherapy Naïve Patients With Extensive-Stage Small Cell Lung Cancer (The MATISSE Study) Unknown status NCT01555710 Phase 3 Carboplatin;Palifosfamide-tris;Etoposide;Carboplatin
17 A Study for Small Cell Lung Cancer (SCLC) in Extensive Disease Stage Unknown status NCT00168896 Phase 2, Phase 3 Carboplatin plus Irinotecan vs Carboplatin plus Etoposide
18 Study of Picoplatin Efficacy After Relapse Unknown status NCT00465491 Phase 3 picoplatin
19 A Prospective Randomized Study Comparing the Target Volume for Limited-stage Small Cell Lung Cancer Unknown status NCT01731548 Phase 2, Phase 3
20 Dalteparin in Preventing Blood Clots in Patients With Lung Cancer Unknown status NCT00519805 Phase 3 dalteparin
21 Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer Unknown status NCT00365105 Phase 3 zoledronic acid;Sm-153
22 Exercise for Patients With Renal Cell Cancer Receiving Sunitinib Unknown status NCT00869011 Phase 3
23 Cabazitaxel vs. Vinflunine in Metastatic or Locally Advanced Transitional Cell Carcinoma of the Urothelium (TCCU) Unknown status NCT01830231 Phase 2, Phase 3 Cabazitaxel;Vinflunine
24 Radiation Therapy or Surgery in Treating Patients Receiving Chemotherapy for Bladder Cancer Unknown status NCT00867347 Phase 3
25 A Study of Standard Treatment +/- Enoxaparin in Small Cell Lung Cancer Completed NCT00717938 Phase 3 cisplatinum or carboplatin and e.g.etoposide.;cisplatinum or carboplatin and e.g.etoposide+enoxaparin
26 AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy Completed NCT00547651 Phase 3 Amrubicin;Topotecan
27 Bevacizumab in Extensive Small Cell Lung Cancer Completed NCT00930891 Phase 2, Phase 3 Standard Chemotherapy (PCDE or PE);Experimental Treatment (PCDE or PE + bevacizumab);Prerandomization Chemotherapy (PCDE or PE)
28 Study Of Irinotecan Hydrochloride (Campto(R)) And Cisplatin Versus Etoposide And Cisplatin In Small Cell Lung Cancer Completed NCT00143455 Phase 3 Etoposide + cisplatin;Irinotecan + cisplatin
29 Trial in Extensive-Disease Small Cell Lung Cancer (ED-SCLC) Subjects Comparing Ipilimumab Plus Etoposide and Platinum Therapy to Etoposide and Platinum Therapy Alone Completed NCT01450761 Phase 3 Etoposide;Cisplatin;Carboplatin
30 Extensive Small Cell Lung Cancer Treatment Using An Investigational Drug Plus Chemotherapy In Chemotherapy-Naive Adults Completed NCT00043927 Phase 3 topotecan/cisplatin;etoposide/cisplatin
31 A Study of Subjects With Previously Untreated Extensive-Stage Small-Cell Lung Cancer (SCLC) Treated With Platinum Plus Etoposide Chemotherapy With or Without Darbepoetin Alfa Completed NCT00119613 Phase 3 placebo;darbepoetin alfa
32 Early Versus Late Concurrent Chemoradiation for Limited Stage Small-cell Lung Cancer Completed NCT01125995 Phase 3
33 Study of Pemetrexed and Carboplatin Compared With Etoposide Carboplatin to Treat Extensive-Stage Small Cell Lung Cancer Completed NCT00363415 Phase 3 pemetrexed;etoposide;carboplatin
34 Randomized Study of Cisplatin-Etoposide Versus an Etoposide Regimen Without Cisplatin in Extensive Small-Cell Lung Cancer Completed NCT00658580 Phase 3 Cisplatin + etoposide;Epirubicin + ifosfamide + etoposide
35 Marimastat Following Chemotherapy in Treating Patients With Small Cell Lung Cancer Completed NCT00003011 Phase 3 marimastat;Placebo
36 Radiation Therapy Plus Combination Chemotherapy In Treating Patients With Limited Stage Small Cell Lung Cancer Completed NCT00003364 Phase 3 cisplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;vincristine sulfate
37 Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission Completed NCT00005062 Phase 3
38 Monoclonal Antibody Therapy Plus BCG in Treating Patients With Limited-Stage Small Cell Lung Cancer Completed NCT00006352 Phase 3
39 Cisplatin Plus Etoposide With or Without Paclitaxel in Treating Patients With Extensive-Stage Small Cell Lung Cancer Completed NCT00003299 Phase 3 cisplatin;etoposide;paclitaxel
40 Carboplatin and Etoposide With or Without Thalidomide in Treating Patients With Limited-Stage or Extensive-Stage Small Cell Lung Cancer Completed NCT00061919 Phase 3 Carboplatin, etoposide & thalidomide;Carboplatin, etoposide & placebo
41 Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer Completed NCT00006349 Phase 3 donepezil hydrochloride
42 S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer Completed NCT00045162 Phase 3 cisplatin;etoposide;irinotecan hydrochloride
43 Vaccination Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer Completed NCT00003279 Phase 3
44 Radiation Therapy to Prevent Brain Metastases in Patients With Previously Treated Extensive-Stage Small Cell Lung Cancer Completed NCT00016211 Phase 3
45 Combination Chemotherapy Followed by Radiation Therapy in Patients With Small Cell Lung Cancer Completed NCT00002822 Phase 3 carboplatin;cisplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
46 Topotecan in Treating Patients With Relapsed Small Cell Lung Cancer Completed NCT00003917 Phase 3 topotecan hydrochloride
47 Survival in a Randomized Phase III Trial in Patients With Limited Disease (LD) Small Cell Lung Cancer Vaccinated With Adjuvant BEC2 and BCG Completed NCT00037713 Phase 3
48 A Study Comparing Irinotecan and Cisplatin (IP) With Etoposide and Cisplatin (EP) Following EP/TRT for LD-SCLC Completed NCT00144989 Phase 3 Etoposide and cisplatin after chemoradiotherapy;Irinotecan and cisplatin after chemoradiotherapy
49 Topotecan Plus Cisplatin Versus Etoposide Plus Cisplatin In 1st Line Extensive Disease Small Cell Lung Cancer Completed NCT00320359 Phase 3 Intravenous topotecan/cisplatin;Intravenous etoposide/cisplatin
50 Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer Completed NCT00041015 Phase 3 cisplatin;etoposide;topotecan hydrochloride

Search NIH Clinical Center for Small Cell Carcinoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Small Cell Carcinoma

Anatomical Context for Small Cell Carcinoma

MalaCards organs/tissues related to Small Cell Carcinoma:

39
Lung, Prostate, Brain, Kidney, Cervix, Skin, Ovary

Publications for Small Cell Carcinoma

Articles related to Small Cell Carcinoma:

(show top 50) (show all 926)
id Title Authors Year
1
Adenocarcinoma of the Lung Acquiring Resistance to Afatinib by Transformation to Small Cell Carcinoma: A Case Report. ( 28878647 )
2017
2
Small Cell Carcinoma Mimicking Acute Leukemia. ( 28794375 )
2017
3
Orthotopic neobladder in patient with locally advanced small cell carcinoma of the bladder: a case report and review of the literature. ( 28458816 )
2017
4
Clinical analysis of small cell carcinoma of the bladder in Chinese: nine case reports and literature reviews. ( 28125986 )
2017
5
Dramatic Response of a Metastatic Primary Small-Cell Carcinoma of the Pancreas to a Trial of Immunotherapy with Nivolumab: A Case Report. ( 28878656 )
2017
6
Primary gastric small cell carcinoma. ( 28363459 )
2017
7
Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases. ( 28804666 )
2017
8
Metastasis of Esophageal Small Cell Carcinoma to the Appendix: A Case Report and Literature Review. ( 28886266 )
2017
9
Intensity-modulated radiation therapy for small cell carcinoma of the prostate: A case report. ( 28761390 )
2017
10
Re: Advanced Small Cell Carcinoma of the Bladder: Clinical Characteristics, Treatment Patterns and Outcomes in 960 Patients and Comparison with Urothelial Carcinoma. ( 28505896 )
2017
11
Clinicopathologic characteristics, therapy and outcomes of patients with primary ureteral small cell carcinoma: a case series and systematic review of the literature. ( 28860819 )
2017
12
SMARCA4 inactivating mutations cause concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type. ( 28608987 )
2017
13
Composite hepatocellular carcinoma and small cell carcinoma with early nodal metastasis: A case report. ( 28834900 )
2017
14
An Extremely Rare Case of Small Cell Carcinoma in Submandibular Salivary Gland. ( 28658784 )
2017
15
Tumor-to-tumor metastasis: Small cell carcinoma lung metastasising into a follicular adenoma of the thyroid. ( 28195115 )
2017
16
Sarcomatoid carcinoma associated with small cell carcinoma of the urinary bladder: a series of 28 cases. ( 28827101 )
2017
17
Bilateral blindness with secondary retinitis pigmentosa following postoperative docetaxel and platinum combination chemotherapy in primary small-cell carcinoma of the endometrium: An unusual case report and review of the literature. ( 28413652 )
2017
18
A Long Survival Woman with Primary Small-Cell Carcinoma of the Gallbladder: Role of Chemotherapy Maintenance. ( 28744415 )
2017
19
Refractory Lactic Acidosis in Small Cell Carcinoma of the Lung. ( 28620552 )
2017
20
Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma. ( 28753872 )
2017
21
Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix. ( 28177947 )
2017
22
Collision tumor of choriocarcinoma and small cell carcinoma of the stomach: A case report. ( 28709051 )
2017
23
Treatment Patterns and Survival Outcomes for Patients with Small Cell Carcinoma of the Bladder. ( 28919521 )
2017
24
The incidence of symptomatic brain metastases from extra-pulmonary small cell carcinoma: Is there a role for prophylactic cranial irradiation in a clinically relevant population cohort? ( 28662868 )
2017
25
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review. ( 28943050 )
2017
26
High expression of Ki-67 is an independent favorable prognostic factor for esophageal small cell carcinoma. ( 28903420 )
2017
27
An update on the developing mitotic inhibitors for the treatment of non-small cell carcinoma. ( 28836854 )
2017
28
Assessment of common somatic mutations of EGFR, KRAS, BRAF, NRAS in pulmonary non-small cell carcinoma using iPLEXAr HS, a new highly sensitive assay for the MassARRAYAr System. ( 28926605 )
2017
29
Transformation to small-cell carcinoma as an acquired resistance mechanism to AZD9291: A case report. ( 28061471 )
2017
30
A case of resistance to tyrosine kinase inhibitor therapy: small cell carcinoma transformation concomitant with plasma-genotyped T790M positivity. ( 28723866 )
2017
31
Acrometastasis as the first sign of an occult non-small cell carcinoma of lung. ( 27294281 )
2016
32
Primary combined small cell carcinoma and squamous cell carcinoma of the oropharynx with special reference to EGFR status of small cell carcinoma component: Case report and review of the literature. ( 27496009 )
2016
33
Small Cell Carcinoma of the Pancreas: A Surgical Disease. ( 27171519 )
2016
34
Predictors of survival in parotid small cell carcinoma: A study of 344 cases. ( 26972357 )
2016
35
Small cell carcinoma of the head and neck: A comparative study by primary site based on population data. ( 27859290 )
2016
36
External beam radiation therapy for small cell carcinoma of the bladder. ( 26948133 )
2016
37
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
38
Genomic landscape of small cell carcinoma of the breast contrasted to small cell carcinoma of the lung. ( 27329168 )
2016
39
Loss of SMARCA4 (BRG1) Protein Expression by Immunohistochemistry in Small Cell Carcinoma of the Ovary, Hypercalcemic Type Distinguishes these Tumors from their Mimics. ( 27100627 )
2016
40
Prognostic significance of serum neuron-specific enolase in small cell carcinoma of the urinary bladder. ( 27180266 )
2016
41
CT scan prior to radiotherapy in unresectable, locally advanced, non-small cell carcinoma of the lung: is it always necessary? ( 27091132 )
2016
42
Non-Small Cell Carcinoma of the Lung With Osteoclast-Like Giant Cells. ( 27899694 )
2016
43
FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma: A Case Report and Regulatory Mechanism Study. ( 26612848 )
2016
44
Small cell carcinoma of the prostate presenting with Cushing Syndrome. A narrative review of an uncommon condition. ( 27068390 )
2016
45
Adjuvant Therapeutic Modalities in Primary Small Cell Carcinoma of Esophagus Patients: A Retrospective Cohort Study of Multicenter Clinical Outcomes. ( 27124057 )
2016
46
Pure small cell carcinoma of the prostate preceded by acute zonal occult outer retinopathy: A case report. ( 27693838 )
2016
47
Small cell carcinoma of the bladder. Report of two cases. ( 27772935 )
2016
48
Small Cell Carcinoma of Anal Canal - A Rare Case Report. ( 27790516 )
2016
49
Cytomorphologic and Immunophenotypic Profile of a Cohort of Small Cell Carcinoma of the Urinary Bladder. ( 27698324 )
2016
50
Primary small cell carcinoma of the vagina with pulmonary metastasis: a case report. ( 27048125 )
2016

Variations for Small Cell Carcinoma

Cosmic variations for Small Cell Carcinoma:

9 (show top 50) (show all 336)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10660 TP53 lung,NS,carcinoma,non small cell carcinoma c.818G>A p.R273H 9
2 COSM10991 TP53 lung,NS,carcinoma,non small cell carcinoma c.396G>T p.K132N 9
3 COSM43896 TP53 lung,NS,carcinoma,non small cell carcinoma c.818G>C p.R273P 9
4 COSM44512 TP53 lung,NS,carcinoma,non small cell carcinoma c.740A>G p.N247S 9
5 COSM44054 TP53 lung,NS,carcinoma,non small cell carcinoma c.754C>T p.L252F 9
6 COSM44622 TP53 lung,NS,carcinoma,non small cell carcinoma c.694A>G p.I232V 9
7 COSM10905 TP53 lung,NS,carcinoma,non small cell carcinoma c.451C>T p.P151S 9
8 COSM11081 TP53 lung,NS,carcinoma,non small cell carcinoma c.733G>T p.G245C 9
9 COSM43597 TP53 lung,NS,carcinoma,non small cell carcinoma c.538G>T p.E180* 9
10 COSM43791 TP53 lung,NS,carcinoma,non small cell carcinoma c.994-2A>T p.? 9
11 COSM43959 TP53 lung,NS,carcinoma,non small cell carcinoma c.790C>A p.L264I 9
12 COSM43911 TP53 lung,NS,carcinoma,non small cell carcinoma c.451C>A p.P151T 9
13 COSM43726 TP53 lung,NS,carcinoma,non small cell carcinoma c.727A>T p.M243L 9
14 COSM10801 TP53 lung,NS,carcinoma,non small cell carcinoma c.404G>A p.C135Y 9
15 COSM45647 TP53 lung,NS,carcinoma,non small cell carcinoma c.760A>T p.I254F 9
16 COSM44776 TP53 lung,NS,carcinoma,non small cell carcinoma c.535C>G p.H179D 9
17 COSM10808 TP53 lung,NS,carcinoma,non small cell carcinoma c.488A>G p.Y163C 9
18 COSM6815 TP53 lung,NS,carcinoma,non small cell carcinoma c.461G>T p.G154V 9
19 COSM43923 TP53 lung,NS,carcinoma,non small cell carcinoma c.800G>A p.R267Q 9
20 COSM43606 TP53 lung,NS,carcinoma,non small cell carcinoma c.734G>A p.G245D 9
21 COSM10704 TP53 lung,NS,carcinoma,non small cell carcinoma c.844C>T p.R282W 9
22 COSM43864 TP53 lung,NS,carcinoma,non small cell carcinoma c.739A>T p.N247Y 9
23 COSM10717 TP53 lung,NS,carcinoma,non small cell carcinoma c.338T>G p.F113C 9
24 COSM45649 TP53 lung,NS,carcinoma,non small cell carcinoma c.854A>G p.E285G 9
25 COSM43559 TP53 lung,NS,carcinoma,non small cell carcinoma c.517G>T p.V173L 9
26 COSM45691 TP53 lung,NS,carcinoma,non small cell carcinoma c.726C>T p.C242C 9
27 COSM10645 TP53 lung,NS,carcinoma,non small cell carcinoma c.527G>T p.C176F 9
28 COSM11205 TP53 lung,NS,carcinoma,non small cell carcinoma c.796G>C p.G266R 9
29 COSM6549 TP53 lung,NS,carcinoma,non small cell carcinoma c.743G>T p.R248L 9
30 COSM44312 TP53 lung,NS,carcinoma,non small cell carcinoma c.511G>A p.E171K 9
31 COSM10662 TP53 lung,NS,carcinoma,non small cell carcinoma c.743G>A p.R248Q 9
32 COSM33649 TP53 lung,NS,carcinoma,non small cell carcinoma c.673-2A>T p.? 9
33 COSM10725 TP53 lung,NS,carcinoma,non small cell carcinoma c.701A>G p.Y234C 9
34 COSM44137 TP53 lung,NS,carcinoma,non small cell carcinoma c.434T>A p.L145Q 9
35 COSM44399 TP53 lung,NS,carcinoma,non small cell carcinoma c.677G>T p.G226V 9
36 COSM10758 TP53 lung,NS,carcinoma,non small cell carcinoma c.659A>G p.Y220C 9
37 COSM10714 TP53 lung,NS,carcinoma,non small cell carcinoma c.473G>T p.R158L 9
38 COSM10656 TP53 lung,NS,carcinoma,non small cell carcinoma c.742C>T p.R248W 9
39 COSM10709 TP53 lung,NS,carcinoma,non small cell carcinoma c.722C>G p.S241C 9
40 COSM10718 TP53 lung,NS,carcinoma,non small cell carcinoma c.524G>T p.R175L 9
41 COSM44769 TP53 lung,NS,carcinoma,non small cell carcinoma c.755T>C p.L252P 9
42 COSM43650 TP53 lung,NS,carcinoma,non small cell carcinoma c.638G>T p.R213L 9
43 COSM45102 TP53 lung,NS,carcinoma,non small cell carcinoma c.423C>T p.C141C 9
44 COSM43687 TP53 lung,NS,carcinoma,non small cell carcinoma c.641A>G p.H214R 9
45 COSM10719 TP53 lung,NS,carcinoma,non small cell carcinoma c.811G>A p.E271K 9
46 COSM43814 TP53 lung,NS,carcinoma,non small cell carcinoma c.587G>C p.R196P 9
47 COSM43871 TP53 lung,NS,carcinoma,non small cell carcinoma c.746G>T p.R249M 9
48 COSM43861 TP53 lung,NS,carcinoma,non small cell carcinoma c.502C>T p.H168Y 9
49 COSM11148 TP53 lung,NS,carcinoma,non small cell carcinoma c.476C>T p.A159V 9
50 COSM43714 TP53 lung,NS,carcinoma,non small cell carcinoma c.836G>A p.G279E 9

Expression for Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for Small Cell Carcinoma

Pathways related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 EGFR KIT PDGFRA PTEN TP53
2
Show member pathways
12.37 EGFR KIT KLK3 PDGFRA PTEN TP53
3 12.28 CALCA ENO2 NCAM1 NKX2-1 SYP
4 12.23 EGFR KIT KLK3 PDGFRA PTEN TP53
5 11.89 EGFR PTEN SMARCA4 TP53
6 11.74 EGFR PTEN SMARCA4 TP53
7 11.72 KIT NCAM1 PTPRC
8 11.68 EGFR KLK3 PTEN
9 11.6 KIT NCAM1 PTPRC
10 11.6 EGFR PDGFRA PTEN TP53
11 11.57 KIT NCAM1 PTPRC
12
Show member pathways
11.52 EGFR KIT PDGFRA
13 11.36 KIT NCAM1 PDGFRA
14 11.32 EGFR PDGFRA TP53
15 11.26 ASCL1 NCAM1 PDGFRA SMARCA4 SYP
16 10.83 EGFR KIT PDGFRA PTEN TP53

GO Terms for Small Cell Carcinoma

Cellular components related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 KIT NCAM1 PDGFRA PTPRC
2 extracellular space GO:0005615 9.23 CALCA CHGA EGFR ENO2 GRP KIT

Biological processes related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.92 ASCL1 EGFR KIT NKX2-1 SMARCA4
2 negative regulation of transcription, DNA-templated GO:0045892 9.91 ASCL1 CALCA NKX2-1 SMARCA4 TP53
3 MAPK cascade GO:0000165 9.85 EGFR KIT NCAM1 PDGFRA
4 lung development GO:0030324 9.73 EGFR NKX2-1 PDGFRA
5 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.65 EGFR KIT PDGFRA
6 mast cell degranulation GO:0043303 9.57 CHGA KIT
7 cerebral cortex cell migration GO:0021795 9.46 EGFR NKX2-1
8 forebrain neuron differentiation GO:0021879 9.43 ASCL1 NKX2-1
9 Leydig cell differentiation GO:0033327 9.4 NKX2-1 PDGFRA
10 positive regulation of phospholipase C activity GO:0010863 9.37 KIT PDGFRA
11 mast cell chemotaxis GO:0002551 9.32 CHGA KIT
12 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900738 9.26 CHGA GRP
13 positive regulation of cAMP metabolic process GO:0030816 9.24 CHGA
14 tongue development GO:0043586 9.19 EGFR
15 cerebral cortex GABAergic interneuron differentiation GO:0021892 9.16 ASCL1 NKX2-1
16 phosphatidylinositol-mediated signaling GO:0048015 9.02 EGFR KIT PDGFRA PTEN TP53
17 mast cell cytokine production GO:0032762 8.96 CHGA KIT

Molecular functions related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.72 CALCA EGFR PTEN SYP TP53
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 EGFR KIT PDGFRA
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.26 EGFR KIT
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 EGFR KIT PDGFRA
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 EGFR KIT NCAM1 PDGFRA

Sources for Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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