MCID: SML001
MIFTS: 56

Small Cell Carcinoma malady

Categories: Cancer diseases, Respiratory diseases, Genetic diseases, Skin diseases, Rare diseases

Aliases & Classifications for Small Cell Carcinoma

Aliases & Descriptions for Small Cell Carcinoma:

Name: Small Cell Carcinoma 12 14
Small Cell Carcinoma, Intermediate Cell 12 69
Small Cell Carcinoma - Intermediate Cell 12
Intermediate Cell Small Cell Carcinoma 12
Small Cell Carcinoma of Lung 69
Carcinoma, Small Cell 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050685
NCIt 47 C4099
SNOMED-CT 64 189557009 5958006
UMLS 69 C0334239

Summaries for Small Cell Carcinoma

Disease Ontology : 12 A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells.

MalaCards based summary : Small Cell Carcinoma, also known as small cell carcinoma, intermediate cell, is related to thymus small cell carcinoma and thyroiditis. An important gene associated with Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Doxorubicin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and cervix, and related phenotypes are cellular and growth/size/body region

Wikipedia : 71 Small-cell carcinoma (also known as \"small-cell lung cancer\", or \"oat-cell carcinoma\") is a type of... more...

Related Diseases for Small Cell Carcinoma

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 6
Basal Cell Carcinoma 5 Basal Cell Carcinoma 4
Basal Cell Carcinoma 7 Cell Type Cancer
Cell Type Benign Neoplasm Basal Cell Carcinoma
Large Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases related to Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
id Related Disease Score Top Affiliating Genes
1 thymus small cell carcinoma 33.4 CHGA ENO2 SYP
2 thyroiditis 30.3 ASCL1 ENO2 KLK3
3 superior vena cava syndrome 30.0 CHGA ENO2 NCAM1 SYP
4 pelvic inflammatory disease 29.6 KRT20 MUC1 SYP
5 choriocarcinoma 29.5 KIT WT1
6 pneumonia 29.4 ENO2 KIT WT1
7 ovarian small cell carcinoma 12.4
8 lung combined type small cell carcinoma 12.2
9 small cell carcinoma of the bladder 12.1
10 prostate small cell carcinoma 12.1
11 gastric small cell carcinoma 12.1
12 laryngeal small cell carcinoma 12.1
13 endometrial small cell carcinoma 12.1
14 hypercalcemic type ovarian small cell carcinoma 12.1
15 gallbladder small cell carcinoma 12.0
16 colon small cell carcinoma 12.0
17 cervix small cell carcinoma 12.0
18 ureter small cell carcinoma 12.0
19 bartholin's gland small cell carcinoma 11.9
20 lung occult small cell carcinoma 11.9
21 pulmonary type ovarian small cell carcinoma 11.9
22 ampulla of vater small cell carcinoma 11.9
23 esophagus small cell carcinoma 11.9
24 small cell cancer of the lung, somatic 11.2
25 merkel cell carcinoma 11.1
26 prostate cancer 11.1
27 lung large cell carcinoma 10.9
28 prostate cancer, hereditary, 13 10.7
29 childhood ovarian cancer 10.7
30 lung combined type small cell adenocarcinoma 10.7
31 penile cancer 10.7
32 prostate cancer, hereditary, 2 10.7
33 prostate cancer 1 10.7
34 prostate cancer, hereditary, 11 10.7
35 rhabdoid tumor predisposition syndrome 2 10.7
36 prostate cancer, hereditary, 12 10.7
37 urachal cancer 10.7
38 prostatitis 10.4
39 peroneal nerve paralysis 10.4 CHGA SYP
40 ampullary signet ring cell adenocarcinoma 10.3 ENO2 NCAM1 SYP
41 villous adenocarcinoma 10.3 CHGA NKX2-1 SYP
42 uterine corpus sarcoma 10.3 ENO2 NCAM1
43 main bronchus cancer 10.3 CHGA NCAM1 SYP
44 piussan lenaerts mathieu syndrome 10.3 CHGA ENO2 SYP
45 pediculus humanus corporis infestation 10.3 CHGA ENO2 SYP
46 vagneur triolle ripert syndrome 10.3 CHGA KLK3
47 cavernous hemangioma of face 10.3 CHGA NKX2-1 SYP
48 infiltrating renal pelvis transitional cell carcinoma 10.3 ENO2 SYP
49 granulocytopenia 10.3 CHGA ENO2 KRT20
50 vulvar alveolar soft part sarcoma 10.3 ENO2 NCAM1 SYP

Graphical network of the top 20 diseases related to Small Cell Carcinoma:



Diseases related to Small Cell Carcinoma

Symptoms & Phenotypes for Small Cell Carcinoma

MGI Mouse Phenotypes related to Small Cell Carcinoma:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 ASCL1 EGFR ENO2 KIT NCAM1 NKX2-1
2 growth/size/body region MP:0005378 10.23 ASCL1 CHGA EGFR ENO2 KIT NKX2-1
3 endocrine/exocrine gland MP:0005379 10.22 ASCL1 CHGA EGFR KIT NKX2-1 PDGFRA
4 mortality/aging MP:0010768 10.21 ASCL1 CHGA EGFR KIT NCAM1 NKX2-1
5 nervous system MP:0003631 10.11 EGFR ENO2 KIT NCAM1 NKX2-1 PDGFRA
6 neoplasm MP:0002006 10.06 PTPRC SMARCA4 TMPRSS2 TP53 WT1 EGFR
7 craniofacial MP:0005382 10.05 ASCL1 EGFR ENO2 KIT PDGFRA SMARCA4
8 digestive/alimentary MP:0005381 10.04 TP53 EGFR KIT NKX2-1 PDGFRA PTPRC
9 normal MP:0002873 10 ASCL1 EGFR KIT NKX2-1 PDGFRA PTPRC
10 no phenotypic analysis MP:0003012 9.92 ASCL1 EGFR KIT NKX2-1 PDGFRA PTPRC
11 renal/urinary system MP:0005367 9.56 EGFR KIT PDGFRA PTPRC SMARCA4 TP53
12 pigmentation MP:0001186 9.55 ASCL1 EGFR KIT PDGFRA TP53
13 respiratory system MP:0005388 9.36 ASCL1 EGFR ENO2 KIT NKX2-1 PDGFRA

Drugs & Therapeutics for Small Cell Carcinoma

Drugs for Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 715)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33069-62-4 36314
3
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
4
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
5
Irinotecan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 97682-44-5, 100286-90-6 60838
6
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 41575-94-4 10339178 498142 38904
7
Gefitinib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 184475-35-2 123631
8
Zoledronic acid Approved Phase 4,Phase 3,Phase 2 118072-93-8 68740
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
10
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
11
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
12
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
13
Pemetrexed Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 150399-23-8, 137281-23-3 446556 60843
14
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-21-8 3385
15
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
16
Trioxsalen Approved Phase 4,Phase 2,Phase 1 3902-71-4 5585
17
Levoleucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 68538-85-2
18
Nicotine Approved Phase 4,Phase 3,Phase 1 54-11-5 942 89594
19
Ribavirin Approved Phase 4,Phase 3 36791-04-5 37542
20
Modafinil Approved, Investigational Phase 4,Phase 2 68693-11-8 4236
21
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
22
Armodafinil Approved, Investigational Phase 4,Phase 2 112111-43-0
23
Edetic Acid Approved, Vet_approved Phase 4,Phase 2 60-00-4, 62-33-9 6049
24
Technetium tc 99m sulfur colloid Approved Phase 4
25
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
26
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 59-30-3 6037
28
Camptothecin Experimental Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7689-03-4
29
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
30 Ether Phase 4,Phase 2,Phase 1
31 interferons Phase 4,Phase 2,Phase 3,Phase 1
32 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 topoisomerase I inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
35 Albumin-Bound Paclitaxel Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Dihematoporphyrin Ether Phase 4,Phase 2,Phase 1
41 Diphosphonates Phase 4,Phase 3,Phase 2
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Photosensitizing Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Plasma Substitutes Phase 4
48 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
49 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2558)
id Name Status NCT ID Phase
1 A Clinical Trial of a Radiation Sensitizer in Radiochemotherapy for Thoracic Esophageal Squamous Carcinoma Unknown status NCT00642239 Phase 4
2 An Expanded Access Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Carcinoma After Failure With Platinum-Containing Chemotherapy Approved for marketing NCT02589717 Phase 4
3 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed NCT00365508 Phase 4
4 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
5 Modafinil for the Treatment of Fatigue in Lung Cancer V9.0 Completed NCT00829322 Phase 4
6 Effect of Zoledronic Acid in Patients With Renal Cell Cancer and Bone Metastasis Completed NCT00172003 Phase 4
7 A Study in Non-squamous Non Small Cell Lung Cancer in Asian Patients Completed NCT01020786 Phase 4
8 Irinotecan Plus Cisplatin Compared With Etoposide Plus Cisplatin for Extensive Stage Small-cell Lung Cancer Recruiting NCT02348450 Phase 4
9 Cetuximab Compared to Mitomycin-C and 5-Fluorouracil for Locally Advanced Squamous Cell Carcinomas of the Head and Neck Recruiting NCT02015650 Phase 4
10 VISmodegib for ORbital and Periocular Basal Cell Carcinoma Recruiting NCT02436408 Phase 4
11 TACE and MWA Combination Therapy in Early-stage Hepatocellular Carcinoma Recruiting NCT02704130 Phase 4
12 Feasibility Study of Using Navigational Bronchoscopy to Perform PDT-Photofrin® in Unresectable Peripheral Lung Cancer Recruiting NCT02916745 Phase 4
13 Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer Recruiting NCT02366819 Phase 4
14 Radiolabeled Molecules for Medullary Thyroid Cancer Recruiting NCT01915485 Phase 4
15 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Active, not recruiting NCT02151149 Phase 4
16 Sentinel Lymph Node Biopsy Findings in Patients With Breast Cancer Active, not recruiting NCT02287675 Phase 4
17 Increased Dose of Icotinib in Advanced None Small Cell Lung Cancer Patients After Routine Gefitinib Therapy Suspended NCT01720901 Phase 4
18 Double Filtration Plasmapheresis for Hepatitis C Virus (HCV) Genotype 1 Patients With High Viral Load Terminated NCT00977054 Phase 4
19 A Post Marketing Surveillance As Required By Philippine Food And Drug Administration Withdrawn NCT01781442 Phase 4
20 STAD-1 Small Cell Lung Cancer Toxicity Adjusted Dosing Study Unknown status NCT00526396 Phase 3
21 Trial of Belotecan/Cisplatin in Chemotherapy Naive Small Cell Lung Cancer Patient Unknown status NCT00826644 Phase 3
22 Combination Chemotherapy in Treating Patients Who Have Extensive-Stage Small Cell Lung Cancer Unknown status NCT00003696 Phase 3
23 Combination Chemotherapy in Treating Patients With Extensive Stage Small Cell Lung Cancer Unknown status NCT00003606 Phase 3
24 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Small Cell Lung Cancer Unknown status NCT00002858 Phase 3
25 Chemotherapy Followed by Peripheral Stem Cell or Bone Marrow Transplant Compared With Chemotherapy Alone in Treating Patients With Small Cell Lung Cancer Unknown status NCT00011921 Phase 3
26 Study of Palifosfamide-tris in Combination With Carboplatin and Etoposide in Chemotherapy Naïve Patients With Extensive-Stage Small Cell Lung Cancer (The MATISSE Study) Unknown status NCT01555710 Phase 3
27 A Study for Small Cell Lung Cancer (SCLC) in Extensive Disease Stage Unknown status NCT00168896 Phase 2, Phase 3
28 Study of Picoplatin Efficacy After Relapse Unknown status NCT00465491 Phase 3
29 A Prospective Randomized Study Comparing the Target Volume for Limited-stage Small Cell Lung Cancer Unknown status NCT01731548 Phase 2, Phase 3
30 Dalteparin in Preventing Blood Clots in Patients With Lung Cancer Unknown status NCT00519805 Phase 3
31 Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer Unknown status NCT00365105 Phase 3
32 Exercise for Patients With Renal Cell Cancer Receiving Sunitinib Unknown status NCT00869011 Phase 3
33 Cabazitaxel vs. Vinflunine in Metastatic or Locally Advanced Transitional Cell Carcinoma of the Urothelium (TCCU) Unknown status NCT01830231 Phase 2, Phase 3
34 Radiation Therapy or Surgery in Treating Patients Receiving Chemotherapy for Bladder Cancer Unknown status NCT00867347 Phase 3
35 Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL Unknown status NCT01039298 Phase 3
36 Effectiveness and Safety of INGN 201 in Combination With Chemotherapy Versus Chemotherapy Alone Unknown status NCT00041626 Phase 3
37 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3
38 Comparison of Four Different Treatment Regimens in Treating Women With Stage I Breast Cancer Unknown status NCT00006030 Phase 3
39 Doxorubicin By Infusion or Chemoembolization in Treating Patients With Advanced Unresectable Hepatocellular Carcinoma (Liver Cancer) Unknown status NCT00079027 Phase 3
40 Carboplatin With Either Paclitaxel Poliglumex or Paclitaxel in Treating Women With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer Unknown status NCT00551733 Phase 3
41 Study of the Telomerase Vaccine GV1001 to Treat Patients With Inoperable Stage III Non-small Cell Lung Cancer Unknown status NCT01579188 Phase 3
42 Docetaxel With or Without Oblimersen in Treating Patients With Non-Small Cell Lung Cancer Unknown status NCT00030641 Phase 2, Phase 3
43 Evaluation of Stents to Open Restricted Airways in Patients With Centrally Placed Non-small Cell Lung Cancer Unknown status NCT01003522 Phase 3
44 Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer Unknown status NCT00954174 Phase 3
45 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3
46 AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy Completed NCT00547651 Phase 3
47 Bevacizumab in Extensive Small Cell Lung Cancer Completed NCT00930891 Phase 2, Phase 3
48 Study Of Irinotecan Hydrochloride (Campto(R)) And Cisplatin Versus Etoposide And Cisplatin In Small Cell Lung Cancer Completed NCT00143455 Phase 3
49 Extensive Small Cell Lung Cancer Treatment Using An Investigational Drug Plus Chemotherapy In Chemotherapy-Naive Adults Completed NCT00043927 Phase 3
50 A Study of Subjects With Previously Untreated Extensive-Stage Small-Cell Lung Cancer (SCLC) Treated With Platinum Plus Etoposide Chemotherapy With or Without Darbepoetin Alfa Completed NCT00119613 Phase 3

Search NIH Clinical Center for Small Cell Carcinoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Small Cell Carcinoma

Anatomical Context for Small Cell Carcinoma

MalaCards organs/tissues related to Small Cell Carcinoma:

39
Lung, Prostate, Cervix, Ovary, Breast, Liver, Thyroid

Publications for Small Cell Carcinoma

Articles related to Small Cell Carcinoma:

(show top 50) (show all 898)
id Title Authors Year
1
Bilateral blindness with secondary retinitis pigmentosa following postoperative docetaxel and platinum combination chemotherapy in primary small-cell carcinoma of the endometrium: An unusual case report and review of the literature. ( 28413652 )
2017
2
Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix. ( 28177947 )
2017
3
Transformation to small-cell carcinoma as an acquired resistance mechanism to AZD9291: A case report. ( 28061471 )
2017
4
A Case of Primary Small-Cell Carcinoma of the Bladder. ( 27920687 )
2016
5
Small-Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review. ( 27991416 )
2016
6
Coughing up - Small cell carcinoma lung with gingival metastasis. ( 27769796 )
2016
7
Cytomorphologic and Immunophenotypic Profile of a Cohort of Small Cell Carcinoma of the Urinary Bladder. ( 27698324 )
2016
8
F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Diagnosing Ovarian Small Cell Carcinoma of the Hypercalcemic Type. ( 26941866 )
2016
9
Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type. ( 26645725 )
2016
10
Treatment and survival outcomes of small cell carcinoma of the esophagus: an analysis of the National Cancer Data Base. ( 27860114 )
2016
11
Small cell carcinoma of the pyriform sinus successfully treated with concurrent chemo-radiotherapy: A case report. ( 27603375 )
2016
12
Ovarian small-cell carcinoma hypercalcemic type successfully treated: a case report and literature review. ( 27042109 )
2016
13
Evaluation of airway resistance in primary small cell carcinoma of the trachea by MostGraph: a case study. ( 27621904 )
2016
14
Small-cell carcinoma of the genitourinary tract: a point of view. ( 27329322 )
2016
15
Urinary bladder carcinoma with divergent differentiation featuring small cell carcinoma, sarcomatoid carcinoma, and liposarcomatous component. ( 27461832 )
2016
16
Small Cell Carcinoma of the Ovary (Hypercalcemic Type): Malignant Rhabdoid Tumor. ( 27462229 )
2016
17
Diagnosis and treatment in primary bladder small cell carcinoma: Literature review. ( 27072176 )
2016
18
A rare case of tonsillar metastatic small cell carcinoma originating from the lung assessed by (18)F-FDG PET/CT. ( 27156163 )
2016
19
Advanced small cell carcinoma of the bladder: clinical characteristics, treatment patterns and outcomes in 960 patients and comparison with urothelial carcinoma. ( 26679712 )
2016
20
Small Cell Carcinoma of the Gall Bladder. ( 27197345 )
2016
21
Pure small cell carcinoma of the prostate preceded by acute zonal occult outer retinopathy: A case report. ( 27693838 )
2016
22
Gallbladder small cell carcinoma: a case report and literature review. ( 27457076 )
2016
23
Adjuvant Therapeutic Modalities in Primary Small Cell Carcinoma of Esophagus Patients: A Retrospective Cohort Study of Multicenter Clinical Outcomes. ( 27124057 )
2016
24
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. ( 26960398 )
2016
25
Primary small cell carcinoma of the vagina with pulmonary metastasis: a case report. ( 27048125 )
2016
26
Small cell carcinoma of the prostate presenting with Cushing Syndrome. A narrative review of an uncommon condition. ( 27068390 )
2016
27
External beam radiation therapy for small cell carcinoma of the bladder. ( 26948133 )
2016
28
Synchronous existence of granular cell tumor and small cell carcinoma of lung: An unusual entity. ( 26960647 )
2016
29
Small Cell Carcinoma of Anal Canal - A Rare Case Report. ( 27790516 )
2016
30
Small Cell Carcinomas of the Bladder Highly Express Somatostatin Receptor Type 2A: Impact on Prognosis and Treatment--A Multicenter Study of Urooncology Society, Turkey. ( 25906124 )
2016
31
Severe Hyponatremia Presenting as Paraneoplastic Syndrome in a Patient with Small Cell Carcinoma of Gallbladder. ( 27225161 )
2016
32
CT scan prior to radiotherapy in unresectable, locally advanced, non-small cell carcinoma of the lung: is it always necessary? ( 27091132 )
2016
33
Small cell carcinoma of the head and neck: A comparative study by primary site based on population data. ( 27859290 )
2016
34
The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. ( 27866340 )
2016
35
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. ( 26990881 )
2016
36
Solitary Spinal Epidural Metastasis from Prostatic Small Cell Carcinoma. ( 27413569 )
2016
37
Predictors of survival in parotid small cell carcinoma: A study of 344 cases. ( 26972357 )
2016
38
Small Cell Carcinoma of the Pancreas: A Surgical Disease. ( 27171519 )
2016
39
Small cell carcinoma of the rectum: A report of imaging results from four cases. ( 26998060 )
2016
40
Response to: "Small-cell carcinoma of the genitourinary tract: a point of view". ( 27330351 )
2016
41
Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor. ( 26646792 )
2016
42
Loss of SMARCA4 (BRG1) Protein Expression by Immunohistochemistry in Small Cell Carcinoma of the Ovary, Hypercalcemic Type Distinguishes these Tumors from their Mimics. ( 27100627 )
2016
43
The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. ( 26975901 )
2016
44
Extrapulmonary Small Cell Carcinoma of the Seminal Vesicles and Prostate Demonstrated on 18F-FDG Positron Emission Tomography/Computed Tomography. ( 27299289 )
2016
45
Small-Cell Carcinoma of the Ovary of Hypercalcemic Type (Malignant Rhabdoid Tumor of the Ovary): A Review with Recent Developments on Pathogenesis. ( 27241105 )
2016
46
Acrometastasis as the first sign of an occult non-small cell carcinoma of lung. ( 27294281 )
2016
47
Extrapulmonary small cell carcinoma of lymph node: Pooled analysis of all reported cases. ( 27298771 )
2016
48
Non-Small Cell Carcinoma of the Lung With Osteoclast-Like Giant Cells. ( 27899694 )
2016
49
A transient increase and subsequent sharp decrease of chemo-refractory liver-metastasized uterine cervical small cell carcinoma to autologous formalin-fixed tumor vaccine plus anti-PD-1 antibody. ( 27386130 )
2016
50
Primary Small Cell Carcinoma of the Pancreas Presenting With Likely Paraneoplastic Features. ( 27144201 )
2016

Variations for Small Cell Carcinoma

Cosmic variations for Small Cell Carcinoma:

9 (show top 50) (show all 317)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM6815 TP53 lung,NS,carcinoma,non small cell carcinoma c.461G>T p.G154V 12
2 COSM10656 TP53 lung,NS,carcinoma,non small cell carcinoma c.742C>T p.R248W 12
3 COSM10801 TP53 lung,NS,carcinoma,non small cell carcinoma c.404G>A p.C135Y 12
4 COSM10893 TP53 lung,NS,carcinoma,non small cell carcinoma c.824G>A p.C275Y 12
5 COSM43650 TP53 lung,NS,carcinoma,non small cell carcinoma c.638G>T p.R213L 12
6 COSM11066 TP53 lung,NS,carcinoma,non small cell carcinoma c.578A>T p.H193L 12
7 COSM10660 TP53 lung,NS,carcinoma,non small cell carcinoma c.818G>A p.R273H 12
8 COSM10991 TP53 lung,NS,carcinoma,non small cell carcinoma c.396G>T p.K132N 12
9 COSM10859 TP53 lung,NS,carcinoma,non small cell carcinoma c.814G>T p.V272L 12
10 COSM45649 TP53 lung,NS,carcinoma,non small cell carcinoma c.854A>G p.E285G 12
11 COSM10834 TP53 lung,NS,carcinoma,non small cell carcinoma c.711G>A p.M237I 12
12 COSM43871 TP53 lung,NS,carcinoma,non small cell carcinoma c.746G>T p.R249M 12
13 COSM11564 TP53 lung,NS,carcinoma,non small cell carcinoma c.742C>G p.R248G 12
14 COSM45102 TP53 lung,NS,carcinoma,non small cell carcinoma c.423C>T p.C141C 12
15 COSM43726 TP53 lung,NS,carcinoma,non small cell carcinoma c.727A>T p.M243L 12
16 COSM43923 TP53 lung,NS,carcinoma,non small cell carcinoma c.800G>A p.R267Q 12
17 COSM10779 TP53 lung,NS,carcinoma,non small cell carcinoma c.818G>T p.R273L 12
18 COSM11232 TP53 lung,NS,carcinoma,non small cell carcinoma c.842A>G p.D281G 12
19 COSM11196 TP53 lung,NS,carcinoma,non small cell carcinoma c.734G>T p.G245V 12
20 COSM44054 TP53 lung,NS,carcinoma,non small cell carcinoma c.754C>T p.L252F 12
21 COSM10662 TP53 lung,NS,carcinoma,non small cell carcinoma c.743G>A p.R248Q 12
22 COSM44776 TP53 lung,NS,carcinoma,non small cell carcinoma c.535C>G p.H179D 12
23 COSM10645 TP53 lung,NS,carcinoma,non small cell carcinoma c.527G>T p.C176F 12
24 COSM43597 TP53 lung,NS,carcinoma,non small cell carcinoma c.538G>T p.E180* 12
25 COSM43814 TP53 lung,NS,carcinoma,non small cell carcinoma c.587G>C p.R196P 12
26 COSM10758 TP53 lung,NS,carcinoma,non small cell carcinoma c.659A>G p.Y220C 12
27 COSM10749 TP53 lung,NS,carcinoma,non small cell carcinoma c.830G>T p.C277F 12
28 COSM44289 TP53 lung,NS,carcinoma,non small cell carcinoma c.497C>T p.S166L 12
29 COSM10808 TP53 lung,NS,carcinoma,non small cell carcinoma c.488A>G p.Y163C 12
30 COSM43687 TP53 lung,NS,carcinoma,non small cell carcinoma c.641A>G p.H214R 12
31 COSM46344 TP53 lung,NS,carcinoma,non small cell carcinoma c.341T>A p.L114* 12
32 COSM10672 TP53 lung,NS,carcinoma,non small cell carcinoma c.577C>T p.H193Y 12
33 COSM43896 TP53 lung,NS,carcinoma,non small cell carcinoma c.818G>C p.R273P 12
34 COSM44610 TP53 lung,NS,carcinoma,non small cell carcinoma c.97-2A>T p.? 12
35 COSM44198 TP53 lung,NS,carcinoma,non small cell carcinoma c.653T>G p.V218G 12
36 COSM44320 TP53 lung,NS,carcinoma,non small cell carcinoma c.484A>T p.I162F 12
37 COSM43606 TP53 lung,NS,carcinoma,non small cell carcinoma c.734G>A p.G245D 12
38 COSM10992 TP53 lung,NS,carcinoma,non small cell carcinoma c.844C>G p.R282G 12
39 COSM44801 TP53 lung,NS,carcinoma,non small cell carcinoma c.503A>T p.H168L 12
40 COSM45647 TP53 lung,NS,carcinoma,non small cell carcinoma c.760A>T p.I254F 12
41 COSM43995 TP53 lung,NS,carcinoma,non small cell carcinoma c.740A>T p.N247I 12
42 COSM44137 TP53 lung,NS,carcinoma,non small cell carcinoma c.434T>A p.L145Q 12
43 COSM11354 TP53 lung,NS,carcinoma,non small cell carcinoma c.991C>T p.Q331* 12
44 COSM43714 TP53 lung,NS,carcinoma,non small cell carcinoma c.836G>A p.G279E 12
45 COSM11063 TP53 lung,NS,carcinoma,non small cell carcinoma c.711G>T p.M237I 12
46 COSM11081 TP53 lung,NS,carcinoma,non small cell carcinoma c.733G>T p.G245C 12
47 COSM43959 TP53 lung,NS,carcinoma,non small cell carcinoma c.790C>A p.L264I 12
48 COSM45632 TP53 lung,NS,carcinoma,non small cell carcinoma c.741C>A p.N247K 12
49 COSM11123 TP53 lung,NS,carcinoma,non small cell carcinoma c.838A>G p.R280G 12
50 COSM10718 TP53 lung,NS,carcinoma,non small cell carcinoma c.524G>T p.R175L 12

Expression for Small Cell Carcinoma

Search GEO for disease gene expression data for Small Cell Carcinoma.

Pathways for Small Cell Carcinoma

GO Terms for Small Cell Carcinoma

Cellular components related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 KIT NCAM1 PDGFRA PTPRC
2 extracellular space GO:0005615 9.23 CALCA CHGA EGFR ENO2 KIT KLK3

Biological processes related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.81 EGFR KIT NCAM1 PDGFRA
2 regulation of transcription from RNA polymerase II promoter GO:0006357 9.73 ASCL1 EGFR KIT NKX2-1 SMARCA4 WT1
3 lung development GO:0030324 9.7 EGFR NKX2-1 PDGFRA
4 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.65 EGFR KIT PDGFRA
5 negative regulation of transcription, DNA-templated GO:0045892 9.63 ASCL1 CALCA NKX2-1 SMARCA4 TP53 WT1
6 mast cell degranulation GO:0043303 9.54 CHGA KIT
7 cerebral cortex cell migration GO:0021795 9.49 EGFR NKX2-1
8 forebrain neuron differentiation GO:0021879 9.46 ASCL1 NKX2-1
9 Leydig cell differentiation GO:0033327 9.43 NKX2-1 PDGFRA
10 positive regulation of phospholipase C activity GO:0010863 9.4 KIT PDGFRA
11 mast cell chemotaxis GO:0002551 9.37 CHGA KIT
12 cerebral cortex GABAergic interneuron differentiation GO:0021892 9.32 ASCL1 NKX2-1
13 phosphatidylinositol-mediated signaling GO:0048015 9.26 EGFR KIT PDGFRA TP53
14 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Small Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.43 MUC1 SMARCA4 TP53
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.33 EGFR KIT PDGFRA
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.32 EGFR KIT
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 EGFR KIT PDGFRA
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 EGFR KIT NCAM1 PDGFRA

Sources for Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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