SCCB
MCID: SML031
MIFTS: 35

Small Cell Carcinoma of the Bladder (SCCB) malady

Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases categories

Summaries for Small Cell Carcinoma of the Bladder

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34MalaCards
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MalaCards: Small Cell Carcinoma of the Bladder, also known as poorly differentiated neuroendocrine carcinoma of the bladder, is related to lung cancer and adenocarcinoma, and has symptoms including pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria, acute abdominal pain/colic and recurrent urinary infections. An important gene associated with Small Cell Carcinoma of the Bladder is SYP (synaptophysin), and among its related pathways is Neuroscience. The compounds smcc and s 100 have been mentioned in the context of this disorder.

Aliases & Classifications for Small Cell Carcinoma of the Bladder

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44NIH Rare Diseases, 50Orphanet, 27ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
poorly differentiated neuroendocrine carcinoma of the bladder:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

small cell carcinoma of the bladder 44 50
poorly differentiated neuroendocrine carcinoma of the bladder 44 50
small cell carcinoma of the urinary bladder 44 50
small cell bladder carcinoma 44 50
small cell bladder cancer 44 50
sccb 44 50


External Ids:

ICD10 via Orphanet27 C67

Related Diseases for Small Cell Carcinoma of the Bladder

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18GeneCards, 19GeneDecks
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Diseases related to Small Cell Carcinoma of the Bladder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.5ENO2, SYP, TP53
2adenocarcinoma30.5TP53, SYP, ENO2
3transitional cell carcinoma30.4ENO2, TP53
4small cell carcinoma10.9
5prostatitis10.5
6bladder carcinoma10.4
7prostate small cell carcinoma10.4
8hypercalcemia10.4
9bladder diverticulum10.4
10hepatitis10.4
11prostate adenocarcinoma10.4
12thyroiditis10.4
13splenomegaly10.4
14dermatomyositis10.3
15melanotic neuroectodermal tumor10.1SYP
16pineoblastoma10.1SYP
17dysembryoplastic neuroepithelial tumor10.1SYP
18cerebral primitive neuroectodermal tumor10.1ENO2
19meningioma10.1SYP
20brain cancer10.0SYP, TP53
21adrenocortical carcinoma10.0SYP, TP53
22oligodendroglioma10.0SYP, TP53
23malignant mixed mullerian tumor10.0ENO2, TP53
24subependymal giant cell astrocytoma10.0ENO2, SYP
25olfactory neuroblastoma10.0ENO2, SYP
26pineocytoma10.0SYP, ENO2
27sertoli cell tumor10.0SYP, ENO2
28neuroepithelioma10.0SYP, ENO2
29granular cell tumor10.0SYP, ENO2
30ganglioneuroblastoma10.0SYP, ENO2
31merkel cell carcinoma10.0ENO2, SYP
32hemangioblastoma10.0ENO2, SYP
33leiomyosarcoma10.0ENO2, TP53
34tubular adenocarcinoma10.0SYP, ENO2
35ganglioglioma10.0ENO2, SYP
36gastrinoma10.0SYP, ENO2
37ganglioneuroma10.0ENO2, SYP
38large cell carcinoma10.0ENO2, SYP
39ependymoma10.0ENO2, SYP
40neuroendocrine carcinoma10.0ENO2, SYP
41paraganglioma10.0SYP, ENO2
42astrocytoma10.0SYP, TP53
43prion disease10.0ENO2, SYP
44rhabdomyosarcoma10.0ENO2, TP53
45neuroendocrine tumor10.0ENO2, SYP
46carcinoid syndrome10.0ENO2, SYP
47vascular disease10.0ENO2, TP53
48lung benign neoplasm10.0ENO2, SYP, TP53
49medulloblastoma10.0ENO2, SYP, TP53
50neuroblastoma10.0TP53, SYP, ENO2

Graphical network of the top 20 diseases related to Small Cell Carcinoma of the Bladder:



Diseases related to small cell carcinoma of the bladder

Symptoms for Small Cell Carcinoma of the Bladder

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50Orphanet
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Symptoms:

50
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute abdominal pain/colic
  • recurrent urinary infections
  • hematuria/microhematuria
  • hypercalcemia
  • ureteral/urethral/vesical/bladder neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Small Cell Carcinoma of the Bladder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Small Cell Carcinoma of the Bladder

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma of the Bladder

Search NIH Clinical Center for Small Cell Carcinoma of the Bladder

Search CenterWatch for Small Cell Carcinoma of the Bladder

Genetic Tests for Small Cell Carcinoma of the Bladder

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Anatomical Context for Small Cell Carcinoma of the Bladder

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Animal Models for Small Cell Carcinoma of the Bladder or affiliated genes

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Publications for Small Cell Carcinoma of the Bladder

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53PubMed
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Articles related to Small Cell Carcinoma of the Bladder:

(show all 21)
idTitleAuthorsYear
1
Locoregional small cell carcinoma of the bladder: clinical characteristics and treatment patterns. (24036236)
2014
2
Local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231456)
2013
3
Editorial comment from Dr Schreiber and Dr Rineer to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231721)
2013
4
Editorial comment from Dr Koga to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231681)
2013
5
Management of small cell carcinoma of the bladder: Consensus guidelines from the Canadian Association of Genitourinary Medical Oncologists (CAGMO). (23671508)
2013
6
Characterization and outcomes of small cell carcinoma of the bladder using the surveillance, epidemiology, and end results database. (22391430)
2013
7
Editorial comment from Dr Ismaili to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231637)
2013
8
Small cell carcinoma of the bladder: a search of the current literature. (23613409)
2013
9
Treatment trends and outcomes of small-cell carcinoma of the bladder: in regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20). (22385714)
2012
10
Treatment trends and outcomes of small-cell carcinoma of the bladder. (22019246)
2012
11
Immunohistochemical profile of urothelial and small cell carcinomas of the bladder. (21203907)
2011
12
A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. (21567387)
2011
13
Small cell carcinoma of the bladder in transplant recipients: a report of 2 cases. (20174486)
2010
14
Dermatomyositis and small cell carcinoma of the bladder. (19826157)
2009
15
Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. (18607595)
2009
16
Outcome of recurrent and metastatic small cell carcinoma of the bladder. (19500382)
2009
17
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. (18547617)
2008
18
Case report: a case with small cell carcinoma of the bladder transformed from urothelial carcinoma]. (18516922)
2008
19
Extrapulmonary small cell carcinoma of the bladder. (17270661)
2007
20
Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness. (17095061)
2006
21
Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladder. (7889499)
1995

Variations for Small Cell Carcinoma of the Bladder

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Expression for genes affiliated with Small Cell Carcinoma of the Bladder

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma of the Bladder

Search GEO for disease gene expression data for Small Cell Carcinoma of the Bladder.

Pathways for genes affiliated with Small Cell Carcinoma of the Bladder

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51PathCards, 5Cell Signaling Technology
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Pathways related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ENO2, SYP

Compounds for genes affiliated with Small Cell Carcinoma of the Bladder

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1smcc469.7ENO2, SYP
2s 100469.7ENO2, SYP
3l-amino acid469.7ENO2, SYP
4hematoxylin469.7ENO2, SYP
5ganglioside469.7SYP, ENO2
6dbc-amp469.7ENO2, SYP
7silver469.7SYP, ENO2
8amine469.6ENO2, SYP
9catecholamine469.6SYP, ENO2
105-hydroxytryptamine469.6SYP, ENO2
11choline46 25 1211.6ENO2, SYP
12formaldehyde46 2510.6ENO2, SYP
13acth469.6ENO2, SYP
14gaba469.6SYP, ENO2
15nmda46 3010.5ENO2, SYP
16norepinephrine46 25 1211.5ENO2, SYP
17acetylcholine46 52 30 25 1213.5SYP, ENO2
18carboplatin46 52 1211.5ENO2, TP53
19glycogen46 2510.4ENO2, SYP
20docetaxel46 52 62 1212.4ENO2, TP53
21dutp469.4SYP, TP53
22potassium46 25 1211.4SYP, ENO2
23forskolin46 52 1211.3ENO2, SYP
24superoxide46 2510.3ENO2, SYP
25glutamine469.2ENO2, SYP
26dopamine46 30 25 1212.0ENO2, SYP
27guanine46 25 1210.9ENO2, SYP, TP53
28etoposide46 52 62 1211.9TP53, SYP, ENO2
29paraffin468.9ENO2, SYP, TP53
30cisplatin46 52 62 1211.9TP53, SYP, ENO2
31progesterone46 30 62 25 1212.9TP53, SYP, ENO2
32vegf468.9ENO2, SYP, TP53
33estrogen468.9ENO2, SYP, TP53
34retinoic acid46 259.9TP53, SYP, ENO2

GO Terms for genes affiliated with Small Cell Carcinoma of the Bladder

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17Gene Ontology
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Cellular components related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0SYP, TP53

Products for genes affiliated with Small Cell Carcinoma of the Bladder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Cell Carcinoma of the Bladder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet