SCCB
MCID: SML031
MIFTS: 23

Small Cell Carcinoma of the Bladder (SCCB) malady

Cancer, Neuronal, Nephrological categories

Summaries for Small Cell Carcinoma of the Bladder

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33MalaCards
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MalaCards: Small Cell Carcinoma of the Bladder, also known as poorly differentiated neuroendocrine carcinoma of the bladder, is related to neuroendocrine carcinoma and brain cancer, and has symptoms including pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria, acute abdominal pain/colic and recurrent urinary infections. An important gene associated with Small Cell Carcinoma of the Bladder is SYP (synaptophysin). The compounds dutp and smcc have been mentioned in the context of this disorder.

Aliases & Classifications for Small Cell Carcinoma of the Bladder

Sources:
43NIH Rare Diseases, 49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal, Nephrological


Characteristics (Orphanet epidemiological data):

49
poorly differentiated neuroendocrine carcinoma of the bladder:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

small cell carcinoma of the bladder 43 49
poorly differentiated neuroendocrine carcinoma of the bladder 43 49
small cell carcinoma of the urinary bladder 43 49
small cell bladder carcinoma 43 49
small cell bladder cancer 43 49
sccb 43 49


External Ids:

ICD10 via Orphanet26 C67

Related Diseases for Small Cell Carcinoma of the Bladder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Small Cell Carcinoma of the Bladder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma30.5ENO2, SYP
2brain cancer30.5SYP, ENO2, TP53
3adenocarcinoma30.5SYP, ENO2, TP53
4transitional cell carcinoma30.3ENO2, TP53
5small cell carcinoma10.9
6bladder carcinoma10.9
7prostate small cell carcinoma10.4
8urinary bladder small cell neuroendocrine carcinoma10.4
9hypercalcemia10.4
10adrenal carcinoma10.4
11bladder adenocarcinoma10.4
12bladder diverticulum10.4
13splenomegaly10.4
14bladder carcinoma in situ10.3
15bladder disease10.3
16bladder transitional cell carcinoma10.3
17rhabdoid tumor10.0SYP
18melanotic neuroectodermal tumor10.0SYP
19pineoblastoma10.0SYP
20dysembryoplastic neuroepithelial tumor10.0SYP
21thymic carcinoma10.0SYP
22teratoma10.0ENO2
23cerebral primitive neuroectodermal tumor10.0ENO2
24gastrointestinal stromal tumor10.0ENO2
25amyotrophic lateral sclerosis10.0SYP
26wilms tumor10.0ENO2
27dementia10.0SYP
28meningioma10.0SYP
29pilocytic astrocytoma10.0SYP
30subependymal giant cell astrocytoma10.0ENO2, SYP
31ganglioneuroblastoma10.0SYP, ENO2
32ganglioglioma10.0ENO2, SYP
33hemangioblastoma10.0ENO2, SYP
34olfactory neuroblastoma10.0SYP, ENO2
35ependymoma10.0SYP, ENO2
36pineocytoma10.0ENO2, SYP
37neuroepithelioma10.0SYP, ENO2
38merkel cell carcinoma10.0ENO2, SYP
39prion disease10.0SYP, ENO2
40tubular adenocarcinoma10.0SYP, ENO2
41large cell carcinoma10.0ENO2, SYP
42pheochromocytoma10.0SYP, ENO2
43sertoli cell tumor10.0SYP, ENO2
44granular cell tumor10.0ENO2, SYP
45ganglioneuroma10.0ENO2, SYP
46gastrinoma10.0SYP, ENO2
47neuroendocrine tumor10.0SYP, ENO2
48adrenocortical carcinoma10.0TP53
49carcinoid syndrome10.0SYP, ENO2
50malignant mixed mullerian tumor10.0TP53, ENO2

Graphical network of the top 20 diseases related to Small Cell Carcinoma of the Bladder:



Diseases related to small cell carcinoma of the bladder

Clinical Features for Small Cell Carcinoma of the Bladder

Sources:
49Orphanet
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Symptoms:

49 (show all 6)
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute abdominal pain/colic
  • recurrent urinary infections
  • hematuria/microhematuria
  • hypercalcemia
  • ureteral/urethral/vesical/bladder neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Small Cell Carcinoma of the Bladder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Small Cell Carcinoma of the Bladder

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma of the Bladder

Search NIH Clinical Center for Small Cell Carcinoma of the Bladder

Search CenterWatch for Small Cell Carcinoma of the Bladder

Genetic Tests for Small Cell Carcinoma of the Bladder

Anatomical Context for Small Cell Carcinoma of the Bladder

Animal Models for Small Cell Carcinoma of the Bladder or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Small Cell Carcinoma of the Bladder

Genetic Variations for Small Cell Carcinoma of the Bladder

Expression for genes affiliated with Small Cell Carcinoma of the Bladder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma of the Bladder

Search GEO for disease gene expression data for Small Cell Carcinoma of the Bladder.

Pathways for genes affiliated with Small Cell Carcinoma of the Bladder

Compounds for genes affiliated with Small Cell Carcinoma of the Bladder

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1dutp459.6TP53, SYP
2smcc459.5ENO2, SYP
3s 100459.5ENO2, SYP
4l-amino acid459.5ENO2, SYP
5hematoxylin459.4SYP, ENO2
6ganglioside459.4ENO2, SYP
7dbc-amp459.4SYP, ENO2
8silver459.4ENO2, SYP
9amine459.3ENO2, SYP
10carboplatin45 50 1111.3ENO2, TP53
11catecholamine459.3ENO2, SYP
12docetaxel45 50 60 1112.1ENO2, TP53
13formaldehyde45 2410.1ENO2, SYP
145-hydroxytryptamine459.0ENO2, SYP
15choline45 11 2410.8ENO2, SYP
16paraffin458.8SYP, ENO2, TP53
17cisplatin45 50 60 1111.8SYP, ENO2, TP53
18progesterone45 60 29 11 2412.8TP53, ENO2, SYP
19vegf458.7SYP, ENO2, TP53
20estrogen458.6TP53, ENO2, SYP
21retinoic acid45 249.5SYP, ENO2, TP53

GO Terms for genes affiliated with Small Cell Carcinoma of the Bladder

Sources:
16Gene Ontology
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Biological processes related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of DNA replicationGO:0081569.3TP53, TTF1

Products for genes affiliated with Small Cell Carcinoma of the Bladder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Cell Carcinoma of the Bladder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet