MCID: SML031
MIFTS: 34

Small Cell Carcinoma of the Bladder

Categories: Rare diseases, Cancer diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Small Cell Carcinoma of the Bladder

MalaCards integrated aliases for Small Cell Carcinoma of the Bladder:

Name: Small Cell Carcinoma of the Bladder 49 55
Small Cell Bladder Cancer 49 55 69
Poorly Differentiated Neuroendocrine Carcinoma of the Bladder 49 55
Small Cell Carcinoma of the Urinary Bladder 49 55
Small Cell Bladder Carcinoma 49 55
Sccb 49 55

Characteristics:

Orphanet epidemiological data:

55
small cell carcinoma of the bladder
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: elderly;

Classifications:

Orphanet: 55  
Rare urogenital diseases


Summaries for Small Cell Carcinoma of the Bladder

NIH Rare Diseases : 49 This condition doesn't have a summary yet. Please see our page(s) on Bladder cancer.

MalaCards based summary : Small Cell Carcinoma of the Bladder, also known as small cell bladder cancer, is related to transitional cell carcinoma and small cell carcinoma, and has symptoms including hematuria, abdominal pain and hypercalcemia. An important gene associated with Small Cell Carcinoma of the Bladder is CHGA (Chromogranin A), and among its related pathways/superpathways is Neuroscience.

Related Diseases for Small Cell Carcinoma of the Bladder

Diseases related to Small Cell Carcinoma of the Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 29.0 ENO2 KRT20 KRT7
2 small cell carcinoma 28.8 CHGA ENO2 KRT20 KRT7 NKX2-1 SYP
3 ureter small cell carcinoma 10.4 CHGA SYP
4 esophageal neuroendocrine tumor 10.4 CHGA SYP
5 acinar cell cystadenocarcinoma 10.4 CHGA SYP
6 peritoneal serous adenocarcinoma 10.4 CHGA SYP
7 cellular ependymoma 10.4 CHGA SYP
8 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
9 gastrointestinal neuroendocrine tumor 10.4 CHGA SYP
10 chordoid meningioma 10.4 CHGA SYP
11 conventional angiosarcoma 10.4 CHGA SYP
12 intracranial primitive neuroectodermal tumor 10.4 CHGA ENO2
13 pancreatoblastoma 10.4 CHGA SYP
14 epithelioid malignant peripheral nerve sheath tumor 10.4 CHGA ENO2
15 pleomorphic xanthoastrocytoma 10.4 CHGA SYP
16 ureter, cancer of 10.4 CHGA SYP
17 acute thyroiditis 10.4 CHGA ENO2
18 nodular ganglioneuroblastoma 10.4 CHGA ENO2
19 tanycytic ependymoma 10.4 CHGA SYP
20 malignant sertoli cell tumor 10.4 ENO2 SYP
21 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
22 non-functioning pancreatic endocrine tumor 10.4 CHGA SYP
23 cutaneous ganglioneuroma 10.4 ENO2 SYP
24 pancreatic somatostatinoma 10.3 ENO2 SYP
25 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
26 papillary tumor of the pineal region 10.3 ENO2 SYP
27 orbital cancer 10.3 ENO2 SYP
28 ovarian carcinosarcoma 10.3 ENO2 SYP
29 pancreatic cystadenocarcinoma 10.3 CHGA SYP
30 binswanger's disease 10.3 CHGA SYP
31 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
32 cerebellum cancer 10.3 ENO2 SYP
33 subependymal glioma 10.3 ENO2 SYP
34 cerebral neuroblastoma 10.3 ENO2 SYP
35 extraosseous chondrosarcoma 10.3 ENO2 SYP
36 benign ependymoma 10.3 ENO2 SYP
37 somatostatinoma 10.3 CHGA ENO2
38 astroblastoma 10.3 ENO2 SYP
39 cerebral ventricle cancer 10.3 ENO2 SYP
40 cerebrum cancer 10.3 ENO2 SYP
41 pineal gland cancer 10.3 ENO2 SYP
42 endometrial small cell carcinoma 10.3 ENO2 SYP
43 melanotic neuroectodermal tumor 10.3 ENO2 SYP
44 spinal canal and spinal cord meningioma 10.3 CHGA ENO2
45 supratentorial cancer 10.3 ENO2 SYP
46 pancreatic gastrinoma 10.3 CHGA SYP
47 angiomyoma 10.3 ENO2 SYP
48 bone benign neoplasm 10.3 ENO2 SYP
49 meningeal melanomatosis 10.3 ENO2 SYP
50 cervical clear cell adenocarcinoma 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Small Cell Carcinoma of the Bladder:



Diseases related to Small Cell Carcinoma of the Bladder

Symptoms & Phenotypes for Small Cell Carcinoma of the Bladder

Human phenotypes related to Small Cell Carcinoma of the Bladder:

55 31 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematuria 55 31 hallmark (90%) Very frequent (99-80%) HP:0000790
2 abdominal pain 55 31 occasional (7.5%) Occasional (29-5%) HP:0002027
3 hypercalcemia 55 31 occasional (7.5%) Occasional (29-5%) HP:0003072
4 bladder neoplasm 55 31 hallmark (90%) Very frequent (99-80%) HP:0009725
5 dysuria 55 31 frequent (33%) Frequent (79-30%) HP:0100518
6 recurrent urinary tract infections 55 31 occasional (7.5%) Occasional (29-5%) HP:0000010

Drugs & Therapeutics for Small Cell Carcinoma of the Bladder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium Recruiting NCT00756639 Phase 2

Search NIH Clinical Center for Small Cell Carcinoma of the Bladder

Genetic Tests for Small Cell Carcinoma of the Bladder

Anatomical Context for Small Cell Carcinoma of the Bladder

Publications for Small Cell Carcinoma of the Bladder

Articles related to Small Cell Carcinoma of the Bladder:

(show all 38)
# Title Authors Year
1
Orthotopic neobladder in patient with locally advanced small cell carcinoma of the bladder: a case report and review of the literature. ( 28458816 )
2017
2
Re: Advanced Small Cell Carcinoma of the Bladder: Clinical Characteristics, Treatment Patterns and Outcomes in 960 Patients and Comparison with Urothelial Carcinoma. ( 28505896 )
2017
3
Clinical analysis of small cell carcinoma of the bladder in Chinese: nine case reports and literature reviews. ( 28125986 )
2017
4
Treatment Patterns and Survival Outcomes for Patients with Small Cell Carcinoma of the Bladder. ( 28919521 )
2017
5
Advanced small cell carcinoma of the bladder: clinical characteristics, treatment patterns and outcomes in 960 patients and comparison with urothelial carcinoma. ( 26679712 )
2016
6
Small-Cell Carcinoma of the Bladder: 20-Year Single-Institution Retrospective Review. ( 27991416 )
2016
7
A Case of Primary Small-Cell Carcinoma of the Bladder. ( 27920687 )
2016
8
Small Cell Carcinomas of the Bladder Highly Express Somatostatin Receptor Type 2A: Impact on Prognosis and Treatment--A Multicenter Study of Urooncology Society, Turkey. ( 25906124 )
2016
9
Small cell carcinoma of the bladder. Report of two cases. ( 27772935 )
2016
10
External beam radiation therapy for small cell carcinoma of the bladder. ( 26948133 )
2016
11
Long-term results of radical cystectomy and role of adjuvant chemotherapy for small cell carcinoma of the bladder. ( 25761779 )
2015
12
Small cell carcinoma of the bladder. ( 25517085 )
2015
13
Small cell carcinoma of the bladder: Our experience. ( 26331396 )
2015
14
Long-term outcomes of organ preservation in patients with small cell carcinoma of the bladder. ( 25660255 )
2015
15
A Baffled Mind: A Mysterious Presentation of Small-Cell Carcinoma of the Bladder. ( 25733058 )
2015
16
Treatment of Small Cell Carcinoma of the Bladder With Chemotherapy and Radiation after Transurethral Resection of a Bladder Tumor. ( 24517956 )
2014
17
Small cell carcinoma of the bladder associated with schistosomiasis: a case report. ( 25803993 )
2014
18
Locoregional small cell carcinoma of the bladder: clinical characteristics and treatment patterns. ( 24036236 )
2014
19
Local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. ( 23231456 )
2013
20
Management of small cell carcinoma of the bladder: Consensus guidelines from the Canadian Association of Genitourinary Medical Oncologists (CAGMO). ( 23671508 )
2013
21
Editorial comment from Dr Ismaili to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. ( 23231637 )
2013
22
Editorial comment from Dr Schreiber and Dr Rineer to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. ( 23231721 )
2013
23
Small cell carcinoma of the bladder: a search of the current literature. ( 23613409 )
2013
24
Characterization and outcomes of small cell carcinoma of the bladder using the surveillance, epidemiology, and end results database. ( 22391430 )
2013
25
Editorial comment from Dr Koga to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. ( 23231681 )
2013
26
Treatment trends and outcomes of small-cell carcinoma of the bladder: in regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20). ( 22385714 )
2012
27
Treatment trends and outcomes of small-cell carcinoma of the bladder. ( 22019246 )
2012
28
Immunohistochemical profile of urothelial and small cell carcinomas of the bladder. ( 21203907 )
2011
29
A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. ( 21567387 )
2011
30
Small cell carcinoma of the bladder in transplant recipients: a report of 2 cases. ( 20174486 )
2010
31
Outcome of recurrent and metastatic small cell carcinoma of the bladder. ( 19500382 )
2009
32
Dermatomyositis and small cell carcinoma of the bladder. ( 19826157 )
2009
33
Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. ( 18607595 )
2009
34
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. ( 18547617 )
2008
35
[Case report: a case with small cell carcinoma of the bladder transformed from urothelial carcinoma]. ( 18516922 )
2008
36
Extrapulmonary small cell carcinoma of the bladder. ( 17270661 )
2007
37
Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness. ( 17095061 )
2006
38
Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladder. ( 7889499 )
1995

Variations for Small Cell Carcinoma of the Bladder

Cosmic variations for Small Cell Carcinoma of the Bladder:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10704 TP53 urinary tract,bladder,carcinoma,small cell carcinoma c.844C>T p.R282W 27
2 COSM4167083 STAG2 urinary tract,bladder,carcinoma,small cell carcinoma c.1113C>G p.F371L 27
3 COSM4167082 urinary tract,bladder,carcinoma,small cell carcinoma c.1113C>G p.F371L 27
4 COSM550 KRAS urinary tract,bladder,carcinoma,undifferentiated carcinoma c.181C>G p.Q61E 24

Expression for Small Cell Carcinoma of the Bladder

Search GEO for disease gene expression data for Small Cell Carcinoma of the Bladder.

Pathways for Small Cell Carcinoma of the Bladder

Pathways related to Small Cell Carcinoma of the Bladder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 NKX2-1 SYP

GO Terms for Small Cell Carcinoma of the Bladder

Sources for Small Cell Carcinoma of the Bladder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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