MCID: SML031
MIFTS: 32

Small Cell Carcinoma of the Bladder malady

Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases categories

Summaries for Small Cell Carcinoma of the Bladder

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MalaCards based summary: Small Cell Carcinoma of the Bladder, also known as poorly differentiated neuroendocrine carcinoma of the bladder, is related to transitional cell carcinoma and lung cancer, and has symptoms including hematuria, urinary tract neoplasm and recurrent urinary tract infections. An important gene associated with Small Cell Carcinoma of the Bladder is SYP (synaptophysin), and among its related pathways is Neuroscience. The compounds smcc and s 100 have been mentioned in the context of this disorder.

Aliases & Classifications for Small Cell Carcinoma of the Bladder

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Sources:
41NIH Rare Diseases, 47Orphanet, 26ICD10 via Orphanet
See all sources

Small Cell Carcinoma of the Bladder, Aliases & Descriptions:

Name: Small Cell Carcinoma of the Bladder 41 47
Poorly Differentiated Neuroendocrine Carcinoma of the Bladder 41 47
Small Cell Carcinoma of the Urinary Bladder 41 47
 
Small Cell Bladder Carcinoma 41 47
Small Cell Bladder Cancer 41 47
Sccb 41 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
poorly differentiated neuroendocrine carcinoma of the bladder:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: elderly


External Ids:

Orphanet47 284400
ICD10 via Orphanet26 C67

Related Diseases for Small Cell Carcinoma of the Bladder

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Diseases related to Small Cell Carcinoma of the Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.3ENO2, TP53
2lung cancer30.2ENO2, SYP, TP53
3adenocarcinoma30.1TP53, SYP, ENO2
4small cell carcinoma11.0
5prostatitis10.5
6hepatitis10.4
7prostate small cell carcinoma10.4
8hypercalcemia10.4
9bladder diverticulum10.4
10prostate adenocarcinoma10.4
11thyroiditis10.4
12melanotic neuroectodermal tumor10.4SYP
13pineoblastoma10.4SYP
14dysembryoplastic neuroepithelial tumor10.4SYP
15ewing's family of tumors10.3ENO2
16dermatomyositis10.3
17schistosomiasis10.3
18meningioma, familial10.2SYP
19brain cancer10.1SYP, TP53
20adrenocortical carcinoma10.1SYP, TP53
21oligodendroglioma10.1SYP, TP53
22malignant mixed mullerian tumor10.0ENO2, TP53
23subependymal giant cell astrocytoma10.0ENO2, SYP
24olfactory neuroblastoma10.0ENO2, SYP
25pineocytoma10.0SYP, ENO2
26sertoli cell tumor10.0SYP, ENO2
27neuroectodermal tumor10.0SYP, ENO2
28granular cell tumor10.0SYP, ENO2
29ganglioneuroblastoma10.0SYP, ENO2
30merkel cell carcinoma10.0ENO2, SYP
31hemangioblastoma10.0ENO2, SYP
32leiomyosarcoma10.0ENO2, TP53
33tubular adenocarcinoma10.0SYP, ENO2
34ganglioglioma10.0ENO2, SYP
35gastrinoma10.0SYP, ENO2
36ganglioneuroma10.0ENO2, SYP
37large cell carcinoma10.0ENO2, SYP
38ependymoma10.0ENO2, SYP
39paraganglioma10.0SYP, ENO2
40astrocytoma10.0SYP, TP53
41brain disease9.9ENO2, SYP
42rhabdomyosarcoma9.9ENO2, TP53
43neuroendocrine tumor9.9ENO2, SYP
44carcinoid syndrome9.9ENO2, SYP
45vascular disease9.9ENO2, TP53
46lung benign neoplasm9.8ENO2, SYP, TP53
47medulloblastoma9.8ENO2, SYP, TP53
48neuroblastoma9.8TP53, SYP, ENO2
49malignant glioma9.8ENO2, SYP, TP53
50small cell cancer of the lung, somatic9.8ENO2, SYP, TP53

Graphical network of the top 20 diseases related to Small Cell Carcinoma of the Bladder:



Diseases related to small cell carcinoma of the bladder

Symptoms for Small Cell Carcinoma of the Bladder

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Symptoms:

 47
  • hematuria/microhematuria
  • ureteral/urethral/vesical/bladder neoplasm/tumor/carcinoma/cancer
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute abdominal pain/colic
  • recurrent urinary infections
  • hypercalcemia

HPO human phenotypes related to Small Cell Carcinoma of the Bladder:

id Description Frequency HPO Source Accession
1 hematuria hallmark (90%) HP:0000790
2 urinary tract neoplasm hallmark (90%) HP:0010786
3 recurrent urinary tract infections occasional (7.5%) HP:0000010
4 abdominal pain occasional (7.5%) HP:0002027
5 hypercalcemia occasional (7.5%) HP:0003072

Drugs & Therapeutics for Small Cell Carcinoma of the Bladder

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Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma of the Bladder

Search NIH Clinical Center for Small Cell Carcinoma of the Bladder

Genetic Tests for Small Cell Carcinoma of the Bladder

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Anatomical Context for Small Cell Carcinoma of the Bladder

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Animal Models for Small Cell Carcinoma of the Bladder or affiliated genes

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Publications for Small Cell Carcinoma of the Bladder

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Articles related to Small Cell Carcinoma of the Bladder:

(show all 24)
idTitleAuthorsYear
1
Long-term results of radical cystectomy and role of adjuvant chemotherapy for small cell carcinoma of the bladder. (25761779)
2015
2
A Baffled Mind: A Mysterious Presentation of Small-Cell Carcinoma of the Bladder. (25733058)
2015
3
Locoregional small cell carcinoma of the bladder: clinical characteristics and treatment patterns. (24036236)
2014
4
Small cell carcinoma of the bladder associated with schistosomiasis: a case report. (25803993)
2014
5
Local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231456)
2013
6
Editorial comment from Dr Schreiber and Dr Rineer to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231721)
2013
7
Editorial comment from Dr Koga to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231681)
2013
8
Management of small cell carcinoma of the bladder: Consensus guidelines from the Canadian Association of Genitourinary Medical Oncologists (CAGMO). (23671508)
2013
9
Characterization and outcomes of small cell carcinoma of the bladder using the surveillance, epidemiology, and end results database. (22391430)
2013
10
Editorial comment from Dr Ismaili to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231637)
2013
11
Small cell carcinoma of the bladder: a search of the current literature. (23613409)
2013
12
Treatment trends and outcomes of small-cell carcinoma of the bladder: in regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20). (22385714)
2012
13
Treatment trends and outcomes of small-cell carcinoma of the bladder. (22019246)
2012
14
Immunohistochemical profile of urothelial and small cell carcinomas of the bladder. (21203907)
2011
15
A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. (21567387)
2011
16
Small cell carcinoma of the bladder in transplant recipients: a report of 2 cases. (20174486)
2010
17
Dermatomyositis and small cell carcinoma of the bladder. (19826157)
2009
18
Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. (18607595)
2009
19
Outcome of recurrent and metastatic small cell carcinoma of the bladder. (19500382)
2009
20
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. (18547617)
2008
21
Case report: a case with small cell carcinoma of the bladder transformed from urothelial carcinoma]. (18516922)
2008
22
Extrapulmonary small cell carcinoma of the bladder. (17270661)
2007
23
Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness. (17095061)
2006
24
Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladder. (7889499)
1995

Variations for Small Cell Carcinoma of the Bladder

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Cosmic variations for Small Cell Carcinoma of the Bladder:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1498HRASurinary tract,bladder,other,neoplasm3
2499HRASurinary tract,bladder,other,neoplasm3
3488HRASurinary tract,bladder,other,neoplasm3
4496HRASurinary tract,bladder,other,neoplasm3
5483HRASurinary tract,bladder,other,neoplasm3

Expression for genes affiliated with Small Cell Carcinoma of the Bladder

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Search GEO for disease gene expression data for Small Cell Carcinoma of the Bladder.

Pathways for genes affiliated with Small Cell Carcinoma of the Bladder

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Pathways related to Small Cell Carcinoma of the Bladder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ENO2, SYP

Compounds for genes affiliated with Small Cell Carcinoma of the Bladder

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Compounds related to Small Cell Carcinoma of the Bladder according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1smcc439.7ENO2, SYP
2s 100439.7ENO2, SYP
3l-amino acid439.7ENO2, SYP
4hematoxylin439.7ENO2, SYP
5ganglioside439.7SYP, ENO2
6dbc-amp439.7ENO2, SYP
7silver439.7SYP, ENO2
8amine439.6ENO2, SYP
9catecholamine439.6SYP, ENO2
105-hydroxytryptamine439.6SYP, ENO2
11choline43 24 1211.6ENO2, SYP
12formaldehyde43 2410.6ENO2, SYP
13acth439.6ENO2, SYP
14gaba439.6SYP, ENO2
15nmda43 2810.5ENO2, SYP
16norepinephrine43 24 1211.5ENO2, SYP
17acetylcholine43 49 28 24 1213.5SYP, ENO2
18carboplatin43 49 1211.5ENO2, TP53
19glycogen43 2410.4ENO2, SYP
20docetaxel43 49 59 1212.4ENO2, TP53
21dutp439.4SYP, TP53
22potassium43 24 1211.4SYP, ENO2
23forskolin43 49 1211.3ENO2, SYP
24superoxide43 2410.3ENO2, SYP
25glutamine439.2ENO2, SYP
26dopamine43 28 24 1212.0ENO2, SYP
27guanine43 24 1210.9ENO2, SYP, TP53
28etoposide43 49 59 1211.9TP53, SYP, ENO2
29paraffin438.9ENO2, SYP, TP53
30cisplatin43 49 59 1211.9TP53, SYP, ENO2
31progesterone43 28 59 24 1212.9TP53, SYP, ENO2
32vegf438.9ENO2, SYP, TP53
33estrogen438.9ENO2, SYP, TP53
34retinoic acid43 249.9TP53, SYP, ENO2

GO Terms for genes affiliated with Small Cell Carcinoma of the Bladder

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Cellular components related to Small Cell Carcinoma of the Bladder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432349.0SYP, TP53

Products for genes affiliated with Small Cell Carcinoma of the Bladder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Small Cell Carcinoma of the Bladder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet