SCCB
MCID: SML031
MIFTS: 35

Small Cell Carcinoma of the Bladder (SCCB) malady

Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases categories
Download this MalaCard

Summaries for Small Cell Carcinoma of the Bladder

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Small Cell Carcinoma of the Bladder, also known as poorly differentiated neuroendocrine carcinoma of the bladder, is related to lung cancer and adenocarcinoma, and has symptoms including pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria, acute abdominal pain/colic and recurrent urinary infections. An important gene associated with Small Cell Carcinoma of the Bladder is SYP (synaptophysin), and among its related pathways is Neuroscience. The compounds smcc and s 100 have been mentioned in the context of this disorder.

Aliases & Classifications for Small Cell Carcinoma of the Bladder

About this section
Sources:
43NIH Rare Diseases, 49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
poorly differentiated neuroendocrine carcinoma of the bladder:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

small cell carcinoma of the bladder 43 49
poorly differentiated neuroendocrine carcinoma of the bladder 43 49
small cell carcinoma of the urinary bladder 43 49
small cell bladder carcinoma 43 49
small cell bladder cancer 43 49
sccb 43 49


External Ids:

ICD10 via Orphanet26 C67

Related Diseases for Small Cell Carcinoma of the Bladder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Small Cell Carcinoma of the Bladder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.5ENO2, SYP, TP53
2adenocarcinoma30.5TP53, SYP, ENO2
3transitional cell carcinoma30.4ENO2, TP53
4small cell carcinoma10.9
5prostatitis10.5
6bladder carcinoma10.4
7prostate small cell carcinoma10.4
8hypercalcemia10.4
9bladder diverticulum10.4
10hepatitis10.4
11prostate adenocarcinoma10.4
12thyroiditis10.4
13splenomegaly10.4
14dermatomyositis10.3
15melanotic neuroectodermal tumor10.1SYP
16pineoblastoma10.1SYP
17dysembryoplastic neuroepithelial tumor10.1SYP
18cerebral primitive neuroectodermal tumor10.1ENO2
19meningioma10.1SYP
20brain cancer10.0SYP, TP53
21adrenocortical carcinoma10.0SYP, TP53
22oligodendroglioma10.0SYP, TP53
23malignant mixed mullerian tumor10.0ENO2, TP53
24subependymal giant cell astrocytoma10.0ENO2, SYP
25olfactory neuroblastoma10.0ENO2, SYP
26pineocytoma10.0SYP, ENO2
27sertoli cell tumor10.0SYP, ENO2
28neuroepithelioma10.0SYP, ENO2
29granular cell tumor10.0SYP, ENO2
30ganglioneuroblastoma10.0SYP, ENO2
31merkel cell carcinoma10.0ENO2, SYP
32hemangioblastoma10.0ENO2, SYP
33leiomyosarcoma10.0ENO2, TP53
34tubular adenocarcinoma10.0SYP, ENO2
35ganglioglioma10.0ENO2, SYP
36gastrinoma10.0SYP, ENO2
37ganglioneuroma10.0ENO2, SYP
38large cell carcinoma10.0ENO2, SYP
39ependymoma10.0ENO2, SYP
40neuroendocrine carcinoma10.0ENO2, SYP
41paraganglioma10.0SYP, ENO2
42astrocytoma10.0SYP, TP53
43prion disease10.0ENO2, SYP
44rhabdomyosarcoma10.0ENO2, TP53
45neuroendocrine tumor10.0ENO2, SYP
46carcinoid syndrome10.0ENO2, SYP
47vascular disease10.0ENO2, TP53
48lung benign neoplasm10.0ENO2, SYP, TP53
49medulloblastoma10.0ENO2, SYP, TP53
50neuroblastoma10.0TP53, SYP, ENO2

Graphical network of the top 20 diseases related to Small Cell Carcinoma of the Bladder:



Diseases related to small cell carcinoma of the bladder

Symptoms for Small Cell Carcinoma of the Bladder

About this section
Sources:
49Orphanet
See all sources


Symptoms:

49
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute abdominal pain/colic
  • recurrent urinary infections
  • hematuria/microhematuria
  • hypercalcemia
  • ureteral/urethral/vesical/bladder neoplasm/tumor/carcinoma/cancer

Drugs & Therapeutics for Small Cell Carcinoma of the Bladder

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma of the Bladder

Search NIH Clinical Center for Small Cell Carcinoma of the Bladder

Genetic Tests for Small Cell Carcinoma of the Bladder

About this section

Anatomical Context for Small Cell Carcinoma of the Bladder

About this section

Animal Models for Small Cell Carcinoma of the Bladder or affiliated genes

About this section

Publications for Small Cell Carcinoma of the Bladder

About this section
Sources:
52PubMed
See all sources

Articles related to Small Cell Carcinoma of the Bladder:

(show all 21)
idTitleAuthorsYear
1
Locoregional small cell carcinoma of the bladder: clinical characteristics and treatment patterns. (24036236)
2014
2
Local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231456)
2013
3
Editorial comment from Dr Schreiber and Dr Rineer to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231721)
2013
4
Editorial comment from Dr Koga to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231681)
2013
5
Management of small cell carcinoma of the bladder: Consensus guidelines from the Canadian Association of Genitourinary Medical Oncologists (CAGMO). (23671508)
2013
6
Characterization and outcomes of small cell carcinoma of the bladder using the surveillance, epidemiology, and end results database. (22391430)
2013
7
Editorial comment from Dr Ismaili to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231637)
2013
8
Small cell carcinoma of the bladder: a search of the current literature. (23613409)
2013
9
Treatment trends and outcomes of small-cell carcinoma of the bladder: in regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20). (22385714)
2012
10
Treatment trends and outcomes of small-cell carcinoma of the bladder. (22019246)
2012
11
Immunohistochemical profile of urothelial and small cell carcinomas of the bladder. (21203907)
2011
12
A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. (21567387)
2011
13
Small cell carcinoma of the bladder in transplant recipients: a report of 2 cases. (20174486)
2010
14
Dermatomyositis and small cell carcinoma of the bladder. (19826157)
2009
15
Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. (18607595)
2009
16
Outcome of recurrent and metastatic small cell carcinoma of the bladder. (19500382)
2009
17
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. (18547617)
2008
18
Case report: a case with small cell carcinoma of the bladder transformed from urothelial carcinoma]. (18516922)
2008
19
Extrapulmonary small cell carcinoma of the bladder. (17270661)
2007
20
Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness. (17095061)
2006
21
Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladder. (7889499)
1995

Variations for Small Cell Carcinoma of the Bladder

About this section

Expression for genes affiliated with Small Cell Carcinoma of the Bladder

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma of the Bladder

Search GEO for disease gene expression data for Small Cell Carcinoma of the Bladder.

Pathways for genes affiliated with Small Cell Carcinoma of the Bladder

About this section
Sources:
50PathCards, 5Cell Signaling Technology
See all sources

Pathways related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ENO2, SYP

Compounds for genes affiliated with Small Cell Carcinoma of the Bladder

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
See all sources

Compounds related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1smcc459.7ENO2, SYP
2s 100459.7ENO2, SYP
3l-amino acid459.7ENO2, SYP
4hematoxylin459.7ENO2, SYP
5ganglioside459.7SYP, ENO2
6dbc-amp459.7ENO2, SYP
7silver459.7SYP, ENO2
8amine459.6ENO2, SYP
9catecholamine459.6SYP, ENO2
105-hydroxytryptamine459.6SYP, ENO2
11choline45 24 1111.6ENO2, SYP
12formaldehyde45 2410.6ENO2, SYP
13acth459.6ENO2, SYP
14gaba459.6SYP, ENO2
15nmda45 2910.5ENO2, SYP
16norepinephrine45 24 1111.5ENO2, SYP
17acetylcholine45 51 29 24 1113.5SYP, ENO2
18carboplatin45 51 1111.5ENO2, TP53
19glycogen45 2410.4ENO2, SYP
20docetaxel45 51 61 1112.4ENO2, TP53
21dutp459.4SYP, TP53
22potassium45 24 1111.4SYP, ENO2
23forskolin45 51 1111.3ENO2, SYP
24superoxide45 2410.3ENO2, SYP
25glutamine459.2ENO2, SYP
26dopamine45 29 24 1112.0ENO2, SYP
27guanine45 24 1110.9ENO2, SYP, TP53
28etoposide45 51 61 1111.9TP53, SYP, ENO2
29paraffin458.9ENO2, SYP, TP53
30cisplatin45 51 61 1111.9TP53, SYP, ENO2
31progesterone45 29 61 24 1112.9TP53, SYP, ENO2
32vegf458.9ENO2, SYP, TP53
33estrogen458.9ENO2, SYP, TP53
34retinoic acid45 249.9TP53, SYP, ENO2

GO Terms for genes affiliated with Small Cell Carcinoma of the Bladder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0SYP, TP53

Products for genes affiliated with Small Cell Carcinoma of the Bladder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Small Cell Carcinoma of the Bladder

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet