SCCB
MCID: SML031
MIFTS: 36

Small Cell Carcinoma of the Bladder (SCCB) malady

Rare diseases, Cancer diseases, Neuronal diseases, Nephrological diseases categories

Summaries for Small Cell Carcinoma of the Bladder

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MalaCards based summary: Small Cell Carcinoma of the Bladder, also known as poorly differentiated neuroendocrine carcinoma of the bladder, is related to transitional cell carcinoma and lung cancer, and has symptoms including hematuria, urinary tract neoplasm and recurrent urinary tract infections. An important gene associated with Small Cell Carcinoma of the Bladder is SYP (synaptophysin), and among its related pathways is Neuroscience. The compounds smcc and s 100 have been mentioned in the context of this disorder.

Aliases & Classifications for Small Cell Carcinoma of the Bladder

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Sources:
42NIH Rare Diseases, 48Orphanet, 27ICD10 via Orphanet
See all sources

Small Cell Carcinoma of the Bladder, Aliases & Descriptions:

Name: Small Cell Carcinoma of the Bladder 42 48
Poorly Differentiated Neuroendocrine Carcinoma of the Bladder 42 48
Small Cell Carcinoma of the Urinary Bladder 42 48
 
Small Cell Bladder Carcinoma 42 48
Small Cell Bladder Cancer 42 48
Sccb 42 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
poorly differentiated neuroendocrine carcinoma of the bladder:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Elderly


External Ids:

ICD10 via Orphanet27 C67

Related Diseases for Small Cell Carcinoma of the Bladder

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Diseases related to Small Cell Carcinoma of the Bladder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1transitional cell carcinoma30.4TP53, ENO2
2lung cancer30.3TP53, ENO2, SYP
3adenocarcinoma30.1SYP, ENO2, TP53
4small cell carcinoma11.0
5prostatitis10.5
6bladder carcinoma10.4
7hepatitis10.4
8prostate small cell carcinoma10.4
9hypercalcemia10.4
10bladder diverticulum10.4
11prostate adenocarcinoma10.4
12thyroiditis10.4
13splenomegaly10.4
14melanotic neuroectodermal tumor10.4SYP
15pineoblastoma10.4SYP
16dysembryoplastic neuroepithelial tumor10.4SYP
17cerebral primitive neuroectodermal tumor10.3ENO2
18dermatomyositis10.3
19meningioma10.2SYP
20brain cancer10.1SYP, TP53
21adrenocortical carcinoma10.1TP53, SYP
22oligodendroglioma10.1SYP, TP53
23malignant mixed mullerian tumor10.0ENO2, TP53
24subependymal giant cell astrocytoma10.0SYP, ENO2
25olfactory neuroblastoma10.0ENO2, SYP
26pineocytoma10.0SYP, ENO2
27sertoli cell tumor10.0SYP, ENO2
28ganglioneuroblastoma10.0ENO2, SYP
29neuroectodermal tumor10.0SYP, ENO2
30granular cell tumor10.0SYP, ENO2
31merkel cell carcinoma10.0ENO2, SYP
32hemangioblastoma10.0SYP, ENO2
33leiomyosarcoma10.0TP53, ENO2
34tubular adenocarcinoma10.0ENO2, SYP
35ganglioglioma10.0SYP, ENO2
36gastrinoma10.0SYP, ENO2
37ganglioneuroma10.0SYP, ENO2
38large cell carcinoma10.0ENO2, SYP
39ependymoma10.0SYP, ENO2
40neuroendocrine carcinoma10.0ENO2, SYP
41paraganglioma10.0ENO2, SYP
42astrocytoma10.0SYP, TP53
43prion disease9.9SYP, ENO2
44rhabdomyosarcoma9.9TP53, ENO2
45neuroendocrine tumor9.9SYP, ENO2
46carcinoid syndrome9.9SYP, ENO2
47vascular disease9.9TP53, ENO2
48lung benign neoplasm9.8TP53, ENO2, SYP
49medulloblastoma9.8ENO2, SYP, TP53
50neuroblastoma9.8ENO2, TP53, SYP

Graphical network of the top 20 diseases related to Small Cell Carcinoma of the Bladder:



Diseases related to small cell carcinoma of the bladder

Symptoms for Small Cell Carcinoma of the Bladder

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Symptoms:

 48
  • hematuria/microhematuria
  • ureteral/urethral/vesical/bladder neoplasm/tumor/carcinoma/cancer
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute abdominal pain/colic
  • recurrent urinary infections
  • hypercalcemia

HPO human phenotypes related to Small Cell Carcinoma of the Bladder:

id Description Frequency HPO Source Accession
1 hematuria hallmark (90%) HP:0000790
2 urinary tract neoplasm hallmark (90%) HP:0010786
3 recurrent urinary tract infections occasional (7.5%) HP:0000010
4 abdominal pain occasional (7.5%) HP:0002027
5 hypercalcemia occasional (7.5%) HP:0003072

Drugs & Therapeutics for Small Cell Carcinoma of the Bladder

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Drug clinical trials:

Search ClinicalTrials for Small Cell Carcinoma of the Bladder

Search NIH Clinical Center for Small Cell Carcinoma of the Bladder

Genetic Tests for Small Cell Carcinoma of the Bladder

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Anatomical Context for Small Cell Carcinoma of the Bladder

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Animal Models for Small Cell Carcinoma of the Bladder or affiliated genes

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Publications for Small Cell Carcinoma of the Bladder

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Articles related to Small Cell Carcinoma of the Bladder:

(show all 21)
idTitleAuthorsYear
1
Locoregional small cell carcinoma of the bladder: clinical characteristics and treatment patterns. (24036236)
2014
2
Local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231456)
2013
3
Editorial comment from Dr Schreiber and Dr Rineer to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231721)
2013
4
Editorial comment from Dr Koga to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231681)
2013
5
Management of small cell carcinoma of the bladder: Consensus guidelines from the Canadian Association of Genitourinary Medical Oncologists (CAGMO). (23671508)
2013
6
Characterization and outcomes of small cell carcinoma of the bladder using the surveillance, epidemiology, and end results database. (22391430)
2013
7
Editorial comment from Dr Ismaili to local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. (23231637)
2013
8
Small cell carcinoma of the bladder: a search of the current literature. (23613409)
2013
9
Treatment trends and outcomes of small-cell carcinoma of the bladder: in regard to Koay et al. (Int J Radiat Oncol Biol Phys 2011 Oct 20). (22385714)
2012
10
Treatment trends and outcomes of small-cell carcinoma of the bladder. (22019246)
2012
11
Immunohistochemical profile of urothelial and small cell carcinomas of the bladder. (21203907)
2011
12
A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. (21567387)
2011
13
Small cell carcinoma of the bladder in transplant recipients: a report of 2 cases. (20174486)
2010
14
Dermatomyositis and small cell carcinoma of the bladder. (19826157)
2009
15
Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. (18607595)
2009
16
Outcome of recurrent and metastatic small cell carcinoma of the bladder. (19500382)
2009
17
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. (18547617)
2008
18
Case report: a case with small cell carcinoma of the bladder transformed from urothelial carcinoma]. (18516922)
2008
19
Extrapulmonary small cell carcinoma of the bladder. (17270661)
2007
20
Ectopic adrenocorticotropic hormone syndrome in a case of small cell carcinoma of the bladder manifesting as severe muscle weakness. (17095061)
2006
21
Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladder. (7889499)
1995

Variations for Small Cell Carcinoma of the Bladder

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Expression for genes affiliated with Small Cell Carcinoma of the Bladder

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Expression patterns in normal tissues for genes affiliated with Small Cell Carcinoma of the Bladder

Search GEO for disease gene expression data for Small Cell Carcinoma of the Bladder.

Pathways for genes affiliated with Small Cell Carcinoma of the Bladder

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Pathways related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ENO2, SYP

Compounds for genes affiliated with Small Cell Carcinoma of the Bladder

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Compounds related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1smcc449.7ENO2, SYP
2s 100449.7ENO2, SYP
3l-amino acid449.7ENO2, SYP
4hematoxylin449.7ENO2, SYP
5ganglioside449.7SYP, ENO2
6dbc-amp449.7ENO2, SYP
7silver449.7SYP, ENO2
8amine449.6ENO2, SYP
9catecholamine449.6SYP, ENO2
105-hydroxytryptamine449.6SYP, ENO2
11choline44 25 1211.6ENO2, SYP
12formaldehyde44 2510.6ENO2, SYP
13acth449.6ENO2, SYP
14gaba449.6SYP, ENO2
15nmda44 2910.5ENO2, SYP
16norepinephrine44 25 1211.5ENO2, SYP
17acetylcholine44 50 29 25 1213.5SYP, ENO2
18carboplatin44 50 1211.5ENO2, TP53
19glycogen44 2510.4ENO2, SYP
20docetaxel44 50 60 1212.4ENO2, TP53
21dutp449.4SYP, TP53
22potassium44 25 1211.4SYP, ENO2
23forskolin44 50 1211.3ENO2, SYP
24superoxide44 2510.3ENO2, SYP
25glutamine449.2ENO2, SYP
26dopamine44 29 25 1212.0ENO2, SYP
27guanine44 25 1210.9ENO2, SYP, TP53
28etoposide44 50 60 1211.9TP53, SYP, ENO2
29paraffin448.9ENO2, SYP, TP53
30cisplatin44 50 60 1211.9TP53, SYP, ENO2
31progesterone44 29 60 25 1212.9TP53, SYP, ENO2
32vegf448.9ENO2, SYP, TP53
33estrogen448.9ENO2, SYP, TP53
34retinoic acid44 259.9TP53, SYP, ENO2

GO Terms for genes affiliated with Small Cell Carcinoma of the Bladder

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Cellular components related to Small Cell Carcinoma of the Bladder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0SYP, TP53

Products for genes affiliated with Small Cell Carcinoma of the Bladder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Small Cell Carcinoma of the Bladder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet