MCID: SML009
MIFTS: 47

Small Intestine Adenocarcinoma malady

Gastrointestinal diseases category

Summaries for Small Intestine Adenocarcinoma

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32MalaCards
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MalaCards: Small Intestine Adenocarcinoma, also known as adenocarcinoma of small intestine, is related to adenocarcinoma and peutz-jeghers syndrome. An important gene associated with Small Intestine Adenocarcinoma is BCL2L2 (BCL2-like 2), and among its related pathways are TGF Beta Signaling Pathway and HTLV-I infection. The compounds butyrate and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, t cells and endothelial, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Aliases & Classifications for Small Intestine Adenocarcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

small intestine adenocarcinoma 8 10
adenocarcinoma of small intestine 60
small intestinal adenocarcinoma 8


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Disease Ontology8 DOID:4906
SNOMED-CT56 424440001
NCIt39 C7888

Related Diseases for Small Intestine Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Small Intestine Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.9BRAF, SMAD4, BCL2L2, ERBB2, APC, CTNNB1
2peutz-jeghers syndrome30.1CTNNB1, APC
3adenoma30.0BRAF, APC, CTNNB1, SMAD4, BCL2L2, HRAS
4mature teratoma10.1
5small bowel adenocarcinoma10.1
6mucinous adenocarcinoma10.1
7acute conjunctivitis10.1
8conjunctivitis10.1
9esophagitis10.0CDX2
10ampulla of vater neoplasm10.0MUC2
11inflammatory bowel disease10.0MUC2
12biliary papillomatosis10.0MUC2
13multiple myeloma10.0HRAS
14rhabdomyosarcoma10.0SMAD4
15hepatitis10.0CPS1
16leiomyoma10.0SMAD4
17influenza10.0HRAS
18leiomyosarcoma10.0MUC1
19meningioma10.0MUC1
20wilms tumor10.0CTNNB1
21hepatitis b10.0HRAS
22acute leukemia10.0HRAS
23ependymoma10.0MUC1
24pancreas disease10.0SMAD4
25cystadenoma10.0BRAF
26gastritis10.0MUC5AC, CDX2
27uterine carcinosarcoma10.0ERBB2
28cervical adenocarcinoma10.0MUC5AC, CDX2
29craniopharyngioma10.0CTNNB1
30pancreatitis10.0HRAS, SMAD4
31pituitary adenoma10.0APC
32cardiofaciocutaneous syndrome10.0BRAF
33bile duct carcinoma10.0MUC2, SMAD4
34rhabdoid tumor10.0MUC1
35papilloma10.0MUC2, MUC5AC
36pseudomyxoma peritonei10.0MUC2, MUC5AC, CDX2
37astrocytoma10.0HRAS
38esophageal cancer10.0CDH1
39biliary tract neoplasm10.0ERBB2, SMAD4
40myeloma10.0BAX, HRAS
41asthma10.0MARCKS, MUC2, MUC5AC
42myeloid leukemia10.0HRAS, BAX
43pancreatic ductal carcinoma10.0MUC2, MUC5AC, SMAD4
44seminoma10.0SMAD4, BRAF
45spitz nevus10.0HRAS, BRAF
46otitis media10.0MUC5AC
47cystadenocarcinoma10.0MUC2, MUC5AC, MUC1
48colorectal cancer10.0CTNNB1, BRAF
49mucinous cystadenocarcinoma10.0MUC1, SMAD4
50osteosarcoma10.0BAX, SMAD4

Graphical network of the top 20 diseases related to Small Intestine Adenocarcinoma:



Diseases related to small intestine adenocarcinoma

Clinical Features for Small Intestine Adenocarcinoma

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Drugs & Therapeutics for Small Intestine Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Small Intestine Adenocarcinoma

Drug clinical trials:

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Search NIH Clinical Center for Small Intestine Adenocarcinoma

Search CenterWatch for Small Intestine Adenocarcinoma

Genetic Tests for Small Intestine Adenocarcinoma

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Anatomical Context for Small Intestine Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Small Intestine Adenocarcinoma:

32
Small intestine, T cells, Endothelial

Animal Models for Small Intestine Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Small Intestine Adenocarcinoma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.7APC, SMAD4
2MP:00053799.7HRAS, CDX2, MUC2, BAX
3MP:00053769.3MUC2, MUC5AC, CDX2, BCL2L2, CPS1
4MP:00053918.9MUC1, MARCKS, APC
5MP:00107718.8SMAD4, HRAS, CDH1, CTNNB1, APC
6MP:00053698.7BRAF, APC, BAX, SMAD4
7MP:00053908.5APC, BAX, MARCKS, CDX2, HRAS
8MP:00053808.5APC, MARCKS, ERBB2, SMAD4
9MP:00036318.0APC, BAX, MARCKS, HRAS, ERBB2
10MP:00053827.7ERBB2, HRAS, MARCKS, CTNNB1, APC, BRAF
11MP:00053897.5BRAF, APC, CTNNB1, BAX, CDH1, CDX2
12MP:00053857.4BRAF, APC, CTNNB1, MUC2, CDH1, CDX2
13MP:00028737.3BRAF, APC, CTNNB1, MUC1, CDH1, CDX2
14MP:00053877.2BRAF, APC, CTNNB1, BAX, MUC2, MUC5AC
15MP:00020067.1BRAF, APC, CTNNB1, MUC2, MUC1, CDH1
16MP:00053847.0BRAF, APC, CTNNB1, BAX, MUC2, CDH1
17MP:00053816.9BRAF, APC, CTNNB1, MUC2, MUC5AC, MUC1
18MP:00053866.8BRAF, APC, CTNNB1, BAX, MARCKS, HRAS
19MP:00053786.0MARCKS, BAX, CTNNB1, APC, BRAF, MUC2
20MP:00107685.9MARCKS, BAX, CTNNB1, APC, BRAF, MUC2

Publications for Small Intestine Adenocarcinoma

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50PubMed
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Articles related to Small Intestine Adenocarcinoma:

(show all 32)
idTitleAuthorsYear
1
Expression of PI3K, PTEN and Akt in small intestinal adenocarcinoma detected by quantum dots-based immunofluorescence technology. (24240591)
2013
2
S100A4 expression is a prognostic indicator in small intestine adenocarcinoma. (24062356)
2013
3
Combined loss of E-cadherin and aberrant I^-catenin protein expression correlates with a poor prognosis for small intestinal adenocarcinomas. (23355201)
2013
4
Expression of Bcl-w protein in human small intestinal adenocarcinoma and effect of Bcl-w siRNA on apoptosis in intestinal adenocarcinoma HuTu-80 cells]. (22780970)
2012
5
Mucinous adenocarcinoma and T-cell lymphoma in the small intestine of 2 Vietnamese potbellied pigs (Sus scrofa). (20974872)
2011
6
Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma. (21088150)
2010
7
Adenocarcinoma of small intestinal type in retroperitoneal mature teratoma. (20846270)
2010
8
Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. (19935793)
2010
9
Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation. (19852062)
2010
10
Intestinal occlusion resulting from a small bowel adenocarcinoma as first onset of Crohn's disease in a healthy patient. (19280822)
2009
11
Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma. (19729672)
2009
12
Intestinal neurofibromatosis and small-bowel adenocarcinoma: a single case study. (19473375)
2009
13
Composite intestinal-type adenocarcinoma and small cell carcinoma of sinonasal tract. (19321468)
2009
14
Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma. (19926579)
2009
15
Small intestine adenocarcinoma in conjunction with multiple adenomas causing acute colic in a horse. (18182527)
2008
16
Adjuvant chemotherapy for small intestine adenocarcinoma. (17636789)
2007
17
Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma. (17951204)
2007
18
Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine. (17022010)
2006
19
Small intestinal adenocarcinoma in Peutz-Jeghers syndrome. (16567896)
2006
20
Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinoma. (16501564)
2006
21
Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestines. (15958853)
2005
22
Mutational activation of the RAS-RAF-MAPK and the Wnt pathway in small intestinal adenocarcinomas. (15513360)
2004
23
Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. (15157044)
2004
24
Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. (15371952)
2004
25
Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine. (14732226)
2004
26
Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study. (14645346)
2003
27
Glutathione S-transferase genotype and p53 mutations in adenocarcinoma of the small intestine. (12940438)
2003
28
Frequent Ki-ras mutations and transforming growth factor-alpha expression in adenocarcinomas of the small intestine: report of 7 cases. (12645812)
2003
29
An insight into the genetic pathway of adenocarcinoma of the small intestine. (11788563)
2002
30
Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene. (11791187)
2002
31
Mutations of the Ki-ras, p53 and APC genes in adenocarcinomas of the human small intestine. (9033644)
1997
32
Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine. (9207270)
1997

Genetic Variations for Small Intestine Adenocarcinoma

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Expression for genes affiliated with Small Intestine Adenocarcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Small Intestine Adenocarcinoma

Search GEO for disease gene expression data for Small Intestine Adenocarcinoma.

Pathways for genes affiliated with Small Intestine Adenocarcinoma

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 12EMD Millipore, 59Tocris Bioscience, 49PharmGKB, 51QIAGEN, 4Cell Signaling Technology, 52R&D Systems, 55SinoBiological
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Pathways related to Small Intestine Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9HRAS, SMAD4
29.9CTNNB1, HRAS
39.9HRAS, CTNNB1
4
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9.8HRAS, BRAF
59.7APC, CTNNB1
69.6CTNNB1, CDH1
79.6CDH1, CTNNB1
89.6HRAS, SMAD4, BRAF
9
Development A2B receptor- action via G-protein alpha s
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9.5CTNNB1, HRAS, BRAF
10
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9.5BAX, HRAS, CTNNB1
11
Mucin expression in CF via IL-6, IL-17 signaling pathways
9.4MUC2, HRAS, MUC5AC
129.4CDH1, CDX2, SMAD4
13
Hide members
9.4HRAS, BRAF, BAX
14
Hide members
9.4HRAS, BAX, BRAF
15
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9.4MUC2, MUC1, MUC5AC
16
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9.4MUC2, MUC1, MUC5AC
17
Hide members
9.3ERBB2, CDH1
18
Development TGF-beta receptor signaling
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9.3ERBB2, SMAD4, HRAS
199.3MUC1, CDH1, CTNNB1
20
Transcription Androgen Receptor nuclear signaling
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9.3HRAS, ERBB2, CTNNB1
219.2APC, BAX, BRAF
22
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9.2BRAF, HRAS, ERBB2
23
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9.2CDH1, CTNNB1, APC
24
Hide members
9.1HRAS, BRAF, BAX, MUC1
259.1CDH1, HRAS, ERBB2
269.1APC, CTNNB1, HRAS, BRAF
279.0HRAS, CDH1, CTNNB1, BRAF
28
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9.0CTNNB1, CDH1, BRAF, HRAS
29
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8.9HRAS, BRAF, SMAD4, ERBB2
308.9APC, HRAS, CTNNB1, CDH1
318.9SMAD4, CTNNB1, CDH1, APC
32
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8.9CTNNB1, APC, SMAD4, CDH1
33
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8.9ERBB2, HRAS, CTNNB1, BRAF
348.9CTNNB1, ERBB2, BRAF, HRAS
35
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8.8BRAF, BAX, ERBB2, HRAS
368.7CTNNB1, MUC1, CDH1, ERBB2
378.6MARCKS, CTNNB1, HRAS, APC
388.6SMAD4, BAX, CTNNB1, BRAF, CDH1
39
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8.5APC, CTNNB1, CDH1, HRAS, BRAF
40
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8.4BAX, ERBB2, SMAD4, APC, CTNNB1
418.4ERBB2, BAX, CTNNB1, APC, SMAD4
42
Hide members
8.3ERBB2, HRAS, CDH1, BAX, CTNNB1
438.1HRAS, BCL2L2, MARCKS, APC, ERBB2
44
Hide members
8.0CTNNB1, BRAF, MUC1, CDH1, HRAS, ERBB2
45
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7.9HRAS, BRAF, APC, CTNNB1, CDH1, ERBB2
46
Hide members
7.6BRAF, CTNNB1, CDH1, HRAS, ERBB2, SMAD4
47
Hide members
7.5APC, CTNNB1, BAX, CDH1, ERBB2, BRAF
487.2HRAS, CDH1, BAX, CTNNB1, APC, BRAF
49
Hide members
7.2CTNNB1, APC, CDH1, HRAS, BRAF, ERBB2
50
Hide members
7.2ERBB2, HRAS, MUC1, BRAF, APC, CTNNB1

Compounds for genes affiliated with Small Intestine Adenocarcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Small Intestine Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1butyrate4410.6CDX2
2hematoxylin4410.3CDH1
3adriamycin449.8MUC1, CTNNB1, BAX
4methylazoxymethanol acetate449.8CTNNB1, APC
51-hydroxyanthraquinone449.7APC, CTNNB1
6sodium bisulfite449.5CDH1, CTNNB1, APC
7exisulind449.2APC, CTNNB1, BAX, CDH1
8gemcitabine44 49 1111.1HRAS, ERBB2, MUC1, BAX
95-aza-2deoxycytidine449.0CDX2, APC, CTNNB1, MUC2, CDH1
10o6-methylguanine449.0BRAF, APC, CDH1
11sulindac44 119.9CTNNB1, CDH1, BAX, HRAS, APC
12geldanamycin44 49 59 1111.9CTNNB1, BRAF, ERBB2, CDH1
13irinotecan44 49 1110.9BAX, BRAF, CDH1, ERBB2
14lithium44 49 11 2411.8APC, MUC1, CTNNB1, MARCKS
15p002448.8ERBB2, BRAF, CTNNB1, CDH1
16celecoxib44 59 28 49 11 2413.5ERBB2, CDH1, CTNNB1, APC, BAX
17methotrexate44 49 1110.5MUC1, MUC5AC, MUC2, ERBB2, CDH1
18vitamin d448.5APC, ERBB2, CDX2, CDH1, CTNNB1
19curcumin448.5APC, ERBB2, CTNNB1, BAX, CDH1
20phosphotyrosine448.5ERBB2, HRAS, CDH1, MUC5AC, CTNNB1
21sb 20358044 599.5CDH1, MUC5AC, MUC2, BAX, BRAF, CTNNB1
22tamoxifen44 49 28 1111.5BAX, CTNNB1, MUC1, CDH1, ERBB2
23phospholipid448.4APC, HRAS, MUC1, MARCKS, CTNNB1
24glucose448.3MUC5AC, HRAS, MUC1, MUC2, APC, BRAF
25paclitaxel44 49 1110.3HRAS, BRAF, CTNNB1, BAX, CDH1, ERBB2
26n acetylcysteine448.3MUC5AC, ERBB2, CTNNB1, BAX, CDH1
2712-o-tetradecanoylphorbol 13-acetate448.3HRAS, CDH1, MUC2, MARCKS, BRAF, MUC1
28rapamycin448.3BRAF, CTNNB1, HRAS, ERBB2, CDH1, APC
29agar448.2CTNNB1, MUC1, CDH1, HRAS, ERBB2, SMAD4
30crcs448.1SMAD4, BRAF, APC, CTNNB1, MUC2, MUC1
31arginine448.1HRAS, SMAD4, CPS1, CTNNB1, ERBB2, CDH1
32doxorubicin44 49 1110.0CDH1, HRAS, ERBB2, BAX, CTNNB1
335fluorouracil447.9MUC5AC, ERBB2, CDH1, MUC1, CTNNB1, BAX
34wortmannin447.9BRAF, APC, CTNNB1, CDH1, ERBB2, BAX
35cisplatin44 49 59 1110.8BRAF, MUC1, BCL2L2, CTNNB1, BAX, CDH1
36testosterone44 59 11 2410.8ERBB2, MUC5AC, MUC1, APC, CDH1, SMAD4
37vegf447.7CTNNB1, HRAS, SMAD4, BRAF, BAX, ERBB2
38cysteine447.6CTNNB1, MUC2, MUC5AC, MUC1, CDH1, CDX2
39alanine447.5BRAF, SMAD4, ERBB2, CDH1, MARCKS, CTNNB1
40retinoic acid44 248.4APC, MUC1, CTNNB1, BAX, MUC2, MUC5AC
41oligonucleotide447.4SMAD4, CDX2, BRAF, APC, MARCKS, MUC2
42ly294002447.3MARCKS, ERBB2, MUC2, HRAS, BAX, CTNNB1
43threonine447.3HRAS, MUC1, MUC5AC, MUC2, CTNNB1, APC
44pd 98,059447.2SMAD4, BRAF, HRAS, CTNNB1, BAX, MARCKS
45progesterone44 59 28 11 2411.0CDH1, HRAS, ERBB2, BRAF, CTNNB1, MUC5AC
46calcium44 49 11 249.7APC, CDX2, HRAS, CDH1, MARCKS, BRAF
47phosphatidylinositol446.6APC, BRAF, CTNNB1, BAX, MARCKS, MUC5AC
48paraffin446.3SMAD4, BRAF, APC, CTNNB1, BAX, MUC5AC
49tyrosine446.1MARCKS, SMAD4, ERBB2, HRAS, CDX2, CDH1
50serine446.1MARCKS, CTNNB1, APC, BRAF, MUC2, MUC5AC

GO Terms for genes affiliated with Small Intestine Adenocarcinoma

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16Gene Ontology
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Cellular components related to Small Intestine Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.6CTNNB1, CDH1
2beta-catenin destruction complexGO:0308779.4APC, CTNNB1
3cell-cell adherens junctionGO:0059139.3CDH1, CTNNB1, APC
4lateral plasma membraneGO:0163289.3CDH1, CTNNB1, APC
5Golgi lumenGO:0057969.3MUC1, MUC5AC, MUC2
6centrosomeGO:0058138.6SMAD4, MARCKS, CTNNB1, APC
7perinuclear region of cytoplasmGO:0484718.6S100A14, CTNNB1, CDH1, HRAS, ERBB2

Biological processes related to Small Intestine Adenocarcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1Sertoli cell proliferationGO:06001110.1BCL2L2, BAX
2midgut developmentGO:0074949.9CPS1, CTNNB1
3cellular response to indole-3-methanolGO:0716819.8CDH1, CTNNB1
4regulation of protein localization to cell surfaceGO:20000089.8CDH1, CTNNB1
5trophectodermal cell differentiationGO:0018299.7CDX2, CDH1
6organ morphogenesisGO:0098879.6BRAF, CDX2, HRAS
7O-glycan processingGO:0162669.5MUC2, MUC5AC, MUC1
8cellular component disassembly involved in execution phase of apoptosisGO:0069219.4APC, CTNNB1, CDH1
9response to toxic substanceGO:0096369.4CPS1, CDH1, BAX
10regulation of microtubule-based processGO:0328869.3ERBB2, APC
11negative regulation of cell proliferationGO:0082858.8SMAD4, HRAS, CTNNB1, APC
12apoptotic processGO:0069158.5BCL2L2, CDH1, BAX, CTNNB1, APC, S100A14

Molecular functions related to Small Intestine Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I-SMAD bindingGO:0704119.6SMAD4, CTNNB1
2gamma-catenin bindingGO:0452959.5CDH1, APC
3protein phosphatase bindingGO:0199038.9CTNNB1, CDH1, ERBB2
4protein bindingGO:0055156.1CPS1, BRAF, APC, CTNNB1, BAX, MUC2

Products for genes affiliated with Small Intestine Adenocarcinoma

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Sources for Small Intestine Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet