MCID: SML014
MIFTS: 35

Small Intestine Leiomyosarcoma

Categories: Gastrointestinal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Small Intestine Leiomyosarcoma

MalaCards integrated aliases for Small Intestine Leiomyosarcoma:

Name: Small Intestine Leiomyosarcoma 12 14 69
Smooth Muscle Connective Tissue Tumor 12
Leiomyosarcoma of the Small Bowel 12
Leiomyosarcoma of Small Intestine 56

Classifications:



External Ids:

Disease Ontology 12 DOID:5271
NCIt 47 C7085
Orphanet 56 ORPHA104076
UMLS via Orphanet 70 C0920305
ICD10 via Orphanet 34 C17.0 C17.1 C17.2 more
UMLS 69 C0920305

Summaries for Small Intestine Leiomyosarcoma

Disease Ontology : 12 A small intestine sarcoma that affects the involuntary smooth muscles of the small intestines.

MalaCards based summary : Small Intestine Leiomyosarcoma, also known as smooth muscle connective tissue tumor, is related to spinal cord melanoma and pseudounicornuate uterus. An important gene associated with Small Intestine Leiomyosarcoma is IHH (Indian Hedgehog), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and C-MYB transcription factor network. The drugs Oxaliplatin and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include small intestine, smooth muscle and breast, and related phenotypes are Decreased human papilloma virus 16 (HPV16) pseudovirus infection and cardiovascular system

Related Diseases for Small Intestine Leiomyosarcoma

Diseases related to Small Intestine Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 spinal cord melanoma 10.4 ADAM17 KIT
2 pseudounicornuate uterus 10.3 IGF2 KIT
3 osteopetrosis 10.3 IGF2 IHH
4 proliferative glomerulonephritis 10.2 IGF2 KIT
5 kidney sarcoma 10.1 IGF2 KIT
6 neurogenic arthropathy 10.1 GCG IGF2
7 perivascular epithelioid cell tumor 10.1 ANO1 KIT
8 chondroma 10.1 GCG IGF2
9 adenosarcoma 10.0 IGF2 KIT
10 appendix leiomyoma 10.0 CD34 KIT
11 anus leiomyoma 10.0 CD34 KIT
12 filamentary keratitis 10.0 CD34 KIT
13 testis rhabdomyosarcoma 10.0 CD34 KIT
14 breast leiomyosarcoma 10.0 CD34 KIT
15 pericoronitis 10.0 CD34 KIT
16 fallopian tube squamous cell carcinoma 10.0 CD34 KIT
17 childhood kidney cell carcinoma 10.0 IGF2 KIT
18 thyroid angiosarcoma 10.0 CD34 KIT
19 demyelinating disease 10.0 CD34 KIT
20 brain stem infarction 10.0 CD34 KIT
21 encephalitozoonosis 10.0 CD34 KIT
22 cutaneous liposarcoma 10.0 CD34 KIT
23 fibrosarcoma of bone 10.0 CD34 KIT
24 epithelioid cell synovial sarcoma 9.9 CD34 KIT
25 peritoneal benign neoplasm 9.9 CD34 KIT
26 kidney hypertrophy 9.9 CD34 KIT
27 vestibular gland benign neoplasm 9.8 CD34 KIT
28 gestational choriocarcinoma 9.8 CD34 KIT
29 pericardial tuberculosis 9.8 CD34 IGF2
30 benign mammary dysplasia 9.8 CD34 KIT
31 leiomyosarcoma 9.8
32 retroperitoneal leiomyosarcoma 9.7 ANO1 IGF2 KIT
33 brown-vialetto-van laere syndrome 9.6 CD34 KIT
34 mediastinum rhabdomyosarcoma 9.5 CD34 IGF2 KIT
35 liver inflammatory pseudotumor 9.4 ANO1 CD34 KIT
36 cowper gland carcinoma 9.4 CD34 GCG IGF2
37 black piedra 9.4 CD34 IGF2
38 bladder urachal squamous cell carcinoma 9.3 CD34 KIT
39 gallbladder cancer 9.1 ADAM17 CD34 IGF2 KIT
40 gastrointestinal stromal tumor 8.9 ANO1 CD34 IGF2 KIT
41 malignant dermis tumor 7.5 ADAM17 ANO1 CD34 GCG IGF2 IHH
42 gallbladder leiomyosarcoma 7.5 ADAM17 ANO1 CD34 GCG IGF2 IHH

Graphical network of the top 20 diseases related to Small Intestine Leiomyosarcoma:



Diseases related to Small Intestine Leiomyosarcoma

Symptoms & Phenotypes for Small Intestine Leiomyosarcoma

GenomeRNAi Phenotypes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00306-A 8.92 GCG IGF2 IHH KIT

MGI Mouse Phenotypes related to Small Intestine Leiomyosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 ADAM17 ANO1 IGF2 IHH KIT
2 integument MP:0010771 9.72 ADAM17 ANO1 CD34 IGF2 KIT
3 limbs/digits/tail MP:0005371 9.56 ADAM17 IGF2 IHH KIT
4 muscle MP:0005369 9.55 ANO1 IGF2 IHH KIT ADAM17
5 respiratory system MP:0005388 9.35 ADAM17 ANO1 IGF2 IHH KIT
6 skeleton MP:0005390 9.02 ADAM17 ANO1 IGF2 IHH KIT

Drugs & Therapeutics for Small Intestine Leiomyosarcoma

Drugs for Small Intestine Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4,Phase 1 61825-94-3 5310940 9887054 43805 6857599
2 Liver Extracts Phase 4,Phase 3,Phase 1
3 Cola Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
6
Ondansetron Approved Phase 3 99614-02-5 4595
7
Cyproheptadine Approved Phase 3 129-03-3 2913
8
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
9 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
10 Adjuvants, Anesthesia Phase 3
11 Analgesics Phase 3
12 Analgesics, Opioid Phase 3
13 Anesthetics Phase 3
14 Anesthetics, General Phase 3
15 Anesthetics, Intravenous Phase 3
16 Central Nervous System Depressants Phase 3
17 Narcotics Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Anti-Anxiety Agents Phase 3
20 Antiemetics Phase 3
21 Anti-Inflammatory Agents Phase 3
22 Antineoplastic Agents, Hormonal Phase 3,Phase 2
23 Antipruritics Phase 3
24 Antipsychotic Agents Phase 3
25 Autonomic Agents Phase 3
26 BB 1101 Phase 3,Phase 2
27 Dermatologic Agents Phase 3
28 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
29 Gastrointestinal Agents Phase 3,Phase 2
30 glucocorticoids Phase 3
31 HIV Protease Inhibitors Phase 3
32 Hormone Antagonists Phase 3
33 Hormones Phase 3
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
35 Neurotransmitter Agents Phase 3
36
protease inhibitors Phase 3
37 Psychotropic Drugs Phase 3
38
Serotonin Phase 3 50-67-9 5202
39 Serotonin Agents Phase 3
40 Serotonin Antagonists Phase 3
41 Tranquilizing Agents Phase 3
42 Anti-Allergic Agents Phase 3
43 Histamine Antagonists Phase 3
44 Histamine H1 Antagonists Phase 3
45
Histamine Phosphate Phase 3 51-74-1 65513
46
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
47
Gemcitabine Approved Phase 2 95058-81-4 60750
48
Lenograstim Approved Phase 2 135968-09-1
49
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
50
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907

Interventional clinical trials:

(show all 29)

id Name Status NCT ID Phase Drugs
1 Relationship Between Platinum Levels in the Blood and Neurotoxicity in Patients Who Are Receiving Oxaliplatin for Gastrointestinal Cancer Unknown status NCT00274885 Phase 4 oxaliplatin
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
6 Gemcitabine, Docetaxel, and Filgrastim in Treating Patients With Recurrent or Persistent Leiomyosarcoma or Soft Tissue Sarcoma Completed NCT00004066 Phase 2 docetaxel;gemcitabine hydrochloride
7 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
8 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
9 Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas Completed NCT00005874 Phase 2 rubitecan
10 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
11 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
12 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
13 Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction Completed NCT00004911 Phase 1, Phase 2
14 Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery Completed NCT00004895 Phase 2 octreotide acetate
15 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
16 Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
17 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
18 Irinotecan and Capecitabine in Treating Patients With Solid Tumors Unknown status NCT00003867 Phase 1 capecitabine;irinotecan hydrochloride
19 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
20 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
21 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin
22 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
23 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
24 PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer Completed NCT00055705 Phase 1
25 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
26 Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients Completed NCT00253383
27 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
28 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 EF5;motexafin lutetium
29 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Heparin;Minocycline-EDTA

Search NIH Clinical Center for Small Intestine Leiomyosarcoma

Genetic Tests for Small Intestine Leiomyosarcoma

Anatomical Context for Small Intestine Leiomyosarcoma

MalaCards organs/tissues related to Small Intestine Leiomyosarcoma:

39
Small Intestine, Smooth Muscle, Breast, Lung, Appendix, Liver

Publications for Small Intestine Leiomyosarcoma

Variations for Small Intestine Leiomyosarcoma

Expression for Small Intestine Leiomyosarcoma

Search GEO for disease gene expression data for Small Intestine Leiomyosarcoma.

Pathways for Small Intestine Leiomyosarcoma

Pathways related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.27 CD34 KIT
2 11.21 CD34 KIT
3 11.14 CD34 KIT
4 10.97 IGF2 IHH
5 10.68 CD34 KIT
6 10.35 IGF2 KIT

GO Terms for Small Intestine Leiomyosarcoma

Cellular components related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.17 ADAM17 ANO1 CD34 GCG IGF2 IHH
2 apical plasma membrane GO:0016324 9.13 ADAM17 ANO1 CD34

Biological processes related to Small Intestine Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.32 IGF2 KIT
2 hemopoiesis GO:0030097 9.26 CD34 KIT
3 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.16 ANO1 GCG
4 cell motility GO:0048870 8.96 ADAM17 CD34
5 positive regulation of cell proliferation GO:0008284 8.8 ADAM17 IGF2 KIT

Sources for Small Intestine Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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