MCID: SML004
MIFTS: 38

Small Intestine Neuroendocrine Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Small Intestine Neuroendocrine Neoplasm

MalaCards integrated aliases for Small Intestine Neuroendocrine Neoplasm:

Name: Small Intestine Neuroendocrine Neoplasm 12 14
Small Intestinal Neuroendocrine Neoplasm 69
Small Intestine Neuroendocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4434
NCIt 47 C5803
UMLS 69 C1336005

Summaries for Small Intestine Neuroendocrine Neoplasm

MalaCards based summary : Small Intestine Neuroendocrine Neoplasm, also known as small intestinal neuroendocrine neoplasm, is related to neuroendocrine tumor and ophthalmia neonatorum. An important gene associated with Small Intestine Neuroendocrine Neoplasm is TPH1 (Tryptophan Hydroxylase 1), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and fMLP Pathway. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, breast and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and behavior/neurological

Related Diseases for Small Intestine Neuroendocrine Neoplasm

Diseases related to Small Intestine Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.2
2 ophthalmia neonatorum 10.0 JUN MAPK8
3 epiphyseal chondrodysplasia, miura type 9.9 MAPK1 MAPK3
4 acute perichondritis of pinna 9.9 MAPK3 MAPK8
5 small cell cancer of the lung, somatic 9.7 JUN MAPK1 MAPK8
6 band keratopathy 9.6 JUN MAPK1 SST
7 bladder cancer, childhood 9.4 APOE SST
8 early-onset parkinson disease 9.4 SST SSTR1
9 autoimmune hepatitis 9.2 APOE JUN MAPK8
10 adrenal cortical carcinoma 8.7 GADD45A MAPK1 MAPK3 MAPK8 SST
11 skull base meningioma 6.6 APOE GADD45A JUN MAPK1 MAPK3 MAPK8

Graphical network of the top 20 diseases related to Small Intestine Neuroendocrine Neoplasm:



Diseases related to Small Intestine Neuroendocrine Neoplasm

Symptoms & Phenotypes for Small Intestine Neuroendocrine Neoplasm

GenomeRNAi Phenotypes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 MAPK3 MAPK8 SST JUN
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 MAPK3 MAPK8 SST JUN MAPK1
3 Decreased telomerase activity GR00156-A 9.13 MAPK1 MAPK3 MAPK8

MGI Mouse Phenotypes related to Small Intestine Neuroendocrine Neoplasm:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 APOE JUN MAPK1 MAPK3 MAPK8 SST
2 homeostasis/metabolism MP:0005376 10.11 SST SSTR1 TPH1 APOE GADD45A JUN
3 cardiovascular system MP:0005385 10.08 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
4 growth/size/body region MP:0005378 10.08 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
5 cellular MP:0005384 10.07 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
6 immune system MP:0005387 9.98 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
7 endocrine/exocrine gland MP:0005379 9.97 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
8 integument MP:0010771 9.95 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
9 digestive/alimentary MP:0005381 9.91 APOE MAPK1 MAPK3 MAPK8 SST
10 nervous system MP:0003631 9.86 APOE GADD45A JUN MAPK1 MAPK3 MAPK8
11 liver/biliary system MP:0005370 9.77 APOE JUN MAPK1 MAPK3 MAPK8
12 muscle MP:0005369 9.72 APOE MAPK1 MAPK3 MAPK8 TPH1
13 respiratory system MP:0005388 9.63 MAPK3 MAPK8 TPH1 APOE JUN MAPK1
14 skeleton MP:0005390 9.43 APOE JUN MAPK1 MAPK3 SST TPH1
15 vision/eye MP:0005391 9.1 APOE JUN MAPK1 MAPK3 MAPK8 SSTR1

Drugs & Therapeutics for Small Intestine Neuroendocrine Neoplasm

Drugs for Small Intestine Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2
Somatostatin Approved Phase 3,Phase 1 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal Phase 3,Phase 1
4 Gastrointestinal Agents Phase 3,Phase 1
5 Hormone Antagonists Phase 3
6 Hormones Phase 3,Phase 1
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
8
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385
9
Hydroxyurea Approved Phase 2 127-07-1 3657
10
Lenograstim Approved Phase 2 135968-09-1
11
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
12
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
13
Floxuridine Approved Phase 2 50-91-9 5790
14
Palonosetron Approved, Investigational Phase 2 135729-61-2, 119904-90-4, 135729-56-5 148211
15
nivolumab Approved Phase 2 946414-94-4
16 Adjuvants, Immunologic Phase 2
17 Anti-Infective Agents Phase 2
18 Antimetabolites Phase 2,Phase 1
19 Antimetabolites, Antineoplastic Phase 2,Phase 1
20 Antiviral Agents Phase 2
21 Immunosuppressive Agents Phase 2,Phase 1
22 Interferon-alpha Phase 2
23 interferons Phase 2
24 Liver Extracts Phase 2,Phase 1
25 Nucleic Acid Synthesis Inhibitors Phase 2
26 Neurotransmitter Agents Phase 2
27
Serotonin Phase 2 50-67-9 5202
28 Serotonin Agents Phase 2
29 Serotonin Antagonists Phase 2
30 Antibodies Phase 2
31 Antibodies, Monoclonal Phase 2
32 Immunoglobulins Phase 2
33 Cola Nutraceutical Phase 1, Phase 2
34
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
35
Levoleucovorin Approved Phase 1 68538-85-2
36
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 43805 6857599
37
Menthol Approved Phase 1 2216-51-5 16666
38
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
39
Camptothecin Experimental Phase 1 7689-03-4
40
7-hydroxystaurosporine Experimental Phase 1 112953-11-4 72271
41 Staurosporine Experimental Phase 1 62996-74-1
42 Antidotes Phase 1
43 Antineoplastic Agents, Phytogenic Phase 1
44 Calcium, Dietary Phase 1
45 Protective Agents Phase 1
46 topoisomerase I inhibitors Phase 1
47 Topoisomerase Inhibitors Phase 1
48 Protein Kinase Inhibitors Phase 1
49 Edotreotide Phase 1
50 glucagon Phase 1

Interventional clinical trials:

(show all 20)

id Name Status NCT ID Phase Drugs
1 A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours Active, not recruiting NCT01578239 Phase 3 Octreotide LAR;177Lu-DOTA0-Tyr3-Octreotate
2 Combination Chemotherapy Plus Interferon Alfa Followed by Filgrastim in Treating Patients With Gastrointestinal Tract Cancer Unknown status NCT00019474 Phase 2 fluorouracil;hydroxyurea
3 Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction Completed NCT00004911 Phase 1, Phase 2
4 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
5 Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer Completed NCT00005049 Phase 2 carboplatin;cisplatin;floxuridine
6 Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer Completed NCT00903396 Phase 2 palonosetron hydrochloride
7 Cobimetinib and Atezolizumab in Advanced Rare Tumors Recruiting NCT03108131 Phase 2 Cobimetinib;Atezolizumab
8 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
9 Study of Pasireotide Long Acting Release (LAR) in Patients With Metastatic Neuroendocrine Tumors (NETs) Active, not recruiting NCT01253161 Phase 2 Pasireotide Long Acting Release (LAR)
10 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer Completed NCT00654160 Phase 1 fluorouracil;irinotecan hydrochloride;leucovorin calcium
11 Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer Completed NCT00003427 Phase 1 irinotecan hydrochloride;oxaliplatin
12 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
13 A Pilot Study Of Ga-68-DOTA-TOC Imaging In Participants With Small Bowel Carcinoid Tumors Not yet recruiting NCT03057509 Phase 1 Ga-68-DOTA-TOC;LAR Octreotide
14 An Investigation of Small Intestinal Carcinoid Carcinoma in Families Unknown status NCT00662168
15 Gastrointestinal Motility in Patients With Neuroendocrine Tumors Completed NCT00789841
16 Diagnostic Performances of Urine and Plasma 5-hydroxyindolacetic Acid (5HIAA) Values in Patients With Small-intestine Neuroendocrine Tumors Recruiting NCT02826928
17 Community-based Neuroendocrine Tumor (NET) Research Study Recruiting NCT02730104
18 Circulating Tumor Cells and Tumor DNA in HCC and NET Recruiting NCT02973204 Sorafenib;Everolimus;Lanreotide
19 Natural History of Familial Carcinoid Tumor Recruiting NCT00646022
20 EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer Terminated NCT00087191 EF5;motexafin lutetium

Search NIH Clinical Center for Small Intestine Neuroendocrine Neoplasm

Genetic Tests for Small Intestine Neuroendocrine Neoplasm

Anatomical Context for Small Intestine Neuroendocrine Neoplasm

MalaCards organs/tissues related to Small Intestine Neuroendocrine Neoplasm:

39
Small Intestine, Breast, Liver, Lung

Publications for Small Intestine Neuroendocrine Neoplasm

Articles related to Small Intestine Neuroendocrine Neoplasm:

id Title Authors Year
1
Chromogranin A and its fragments as regulators of small intestinal neuroendocrine neoplasm proliferation. ( 24260544 )
2013

Variations for Small Intestine Neuroendocrine Neoplasm

Expression for Small Intestine Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Small Intestine Neuroendocrine Neoplasm.

Pathways for Small Intestine Neuroendocrine Neoplasm

Pathways related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 JUN MAPK1 MAPK3 MAPK8
2
Show member pathways
12.96 JUN MAPK1 MAPK3 MAPK8
3
Show member pathways
12.9 JUN MAPK1 MAPK3 MAPK8
4
Show member pathways
12.9 JUN MAPK1 MAPK3 MAPK8
5
Show member pathways
12.88 JUN MAPK1 MAPK3 MAPK8
6
Show member pathways
12.88 JUN MAPK1 MAPK3 MAPK8
7
Show member pathways
12.87 JUN MAPK1 MAPK3 MAPK8
8
Show member pathways
12.86 JUN MAPK1 MAPK3 MAPK8
9
Show member pathways
12.86 JUN MAPK1 MAPK3 MAPK8
10
Show member pathways
12.85 JUN MAPK1 MAPK3 MAPK8
11
Show member pathways
12.85 JUN MAPK1 MAPK3 MAPK8
12
Show member pathways
12.82 GADD45A JUN MAPK1 MAPK3 MAPK8
13
Show member pathways
12.79 JUN MAPK1 MAPK3 MAPK8
14
Show member pathways
12.78 JUN MAPK1 MAPK3 MAPK8
15
Show member pathways
12.78 JUN MAPK1 MAPK3 MAPK8
16
Show member pathways
12.76 JUN MAPK1 MAPK3 MAPK8
17 12.72 GADD45A JUN MAPK1 MAPK3 MAPK8
18 12.66 JUN MAPK1 MAPK3 MAPK8
19
Show member pathways
12.66 JUN MAPK1 MAPK3 MAPK8
20
Show member pathways
12.63 JUN MAPK1 MAPK3 MAPK8
21
Show member pathways
12.61 JUN MAPK1 MAPK3 MAPK8
22
Show member pathways
12.6 JUN MAPK1 MAPK3 MAPK8
23
Show member pathways
12.59 JUN MAPK1 MAPK3 MAPK8
24
Show member pathways
12.58 JUN MAPK1 MAPK3 MAPK8
25
Show member pathways
12.54 JUN MAPK1 MAPK3 MAPK8
26
Show member pathways
12.53 JUN MAPK1 MAPK3 MAPK8
27
Show member pathways
12.52 GADD45A JUN MAPK1 MAPK3 MAPK8
28
Show member pathways
12.5 JUN MAPK1 MAPK3 MAPK8
29
Show member pathways
12.46 JUN MAPK1 MAPK3 MAPK8
30
Show member pathways
12.45 JUN MAPK1 MAPK3 MAPK8
31
Show member pathways
12.45 JUN MAPK1 MAPK3 MAPK8
32 12.44 JUN MAPK1 MAPK3 MAPK8
33
Show member pathways
12.42 JUN MAPK1 MAPK3 MAPK8
34
Show member pathways
12.41 JUN MAPK1 MAPK3 MAPK8
35
Show member pathways
12.39 JUN MAPK1 MAPK3
36
Show member pathways
12.39 JUN MAPK1 MAPK3 MAPK8
37
Show member pathways
12.38 MAPK1 MAPK3 MAPK8
38
Show member pathways
12.37 JUN MAPK1 MAPK3
39
Show member pathways
12.36 JUN MAPK1 MAPK3 MAPK8
40
Show member pathways
12.35 GADD45A MAPK1 MAPK3
41
Show member pathways
12.34 MAPK1 MAPK3 MAPK8
42
Show member pathways
12.34 JUN MAPK1 MAPK3 MAPK8
43
Show member pathways
12.33 JUN MAPK1 MAPK3
44
Show member pathways
12.33 JUN MAPK1 MAPK3 MAPK8
46
Show member pathways
12.3 JUN MAPK1 MAPK3 MAPK8
47
Show member pathways
12.3 JUN MAPK1 MAPK3 MAPK8
48
Show member pathways
12.29 MAPK1 MAPK3 MAPK8
49 12.29 JUN MAPK1 MAPK3
50
Show member pathways
12.28 JUN MAPK1 MAPK3 MAPK8

GO Terms for Small Intestine Neuroendocrine Neoplasm

Cellular components related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pseudopodium GO:0031143 8.62 MAPK1 MAPK3

Biological processes related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.82 JUN MAPK1 MAPK3
2 peptidyl-serine phosphorylation GO:0018105 9.79 MAPK1 MAPK3 MAPK8
3 cellular response to mechanical stimulus GO:0071260 9.72 GADD45A MAPK3 MAPK8
4 response to stress GO:0006950 9.69 GADD45A MAPK1 MAPK8
5 positive regulation of telomere maintenance via telomerase GO:0032212 9.67 MAPK1 MAPK3
6 positive regulation of telomerase activity GO:0051973 9.66 MAPK1 MAPK3
7 response to exogenous dsRNA GO:0043330 9.66 MAPK1 MAPK3
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 MAPK1 MAPK3
9 ERK1 and ERK2 cascade GO:0070371 9.65 MAPK1 MAPK3
10 thyroid gland development GO:0030878 9.64 MAPK1 MAPK3
11 regulation of cytoskeleton organization GO:0051493 9.64 MAPK1 MAPK3
12 neural crest cell development GO:0014032 9.63 MAPK1 MAPK3
13 lung morphogenesis GO:0060425 9.63 MAPK1 MAPK3
14 face development GO:0060324 9.62 MAPK1 MAPK3
15 Fc-epsilon receptor signaling pathway GO:0038095 9.62 JUN MAPK1 MAPK3 MAPK8
16 positive regulation of telomere capping GO:1904355 9.61 MAPK1 MAPK3
17 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.61 MAPK1 MAPK3
18 cellular response to dopamine GO:1903351 9.6 MAPK1 MAPK3
19 regulation of ossification GO:0030278 9.59 MAPK1 MAPK3
20 outer ear morphogenesis GO:0042473 9.58 MAPK1 MAPK3
21 regulation of stress-activated MAPK cascade GO:0032872 9.58 MAPK1 MAPK3
22 Bergmann glial cell differentiation GO:0060020 9.57 MAPK1 MAPK3
23 regulation of early endosome to late endosome transport GO:2000641 9.56 MAPK1 MAPK3
24 trachea formation GO:0060440 9.54 MAPK1 MAPK3
25 cellular response to amino acid starvation GO:0034198 9.54 MAPK1 MAPK3 MAPK8
26 caveolin-mediated endocytosis GO:0072584 9.52 MAPK1 MAPK3
27 regulation of Golgi inheritance GO:0090170 9.49 MAPK1 MAPK3
28 response to epidermal growth factor GO:0070849 9.48 MAPK1 MAPK3
29 cardiac neural crest cell development involved in heart development GO:0061308 9.46 MAPK1 MAPK3
30 cellular response to reactive oxygen species GO:0034614 9.46 JUN MAPK1 MAPK3 MAPK8
31 MAPK import into nucleus GO:0000189 9.43 MAPK1 MAPK3
32 stress-activated MAPK cascade GO:0051403 9.43 MAPK1 MAPK3 MAPK8
33 positive regulation of cyclase activity GO:0031281 9.4 MAPK3 MAPK8
34 cellular response to cadmium ion GO:0071276 9.26 JUN MAPK1 MAPK3 MAPK8
35 regulation of sequence-specific DNA binding transcription factor activity GO:0051090 8.92 JUN MAPK1 MAPK3 MAPK8

Molecular functions related to Small Intestine Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphotyrosine binding GO:0001784 8.96 MAPK1 MAPK3
2 MAP kinase activity GO:0004707 8.8 MAPK1 MAPK3 MAPK8

Sources for Small Intestine Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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