MCID: SML019
MIFTS: 53

Smallpox malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Smallpox

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Aliases & Descriptions for Smallpox:

Name: Smallpox 11 47 49 37 2 38 13 67
Ordinary Smallpox 11
 
Variola 47

Classifications:



External Ids:

Disease Ontology11 DOID:8736
ICD1029 B03
ICD9CM31 050, 050.9
MeSH38 D012899
NCIt44 C35027

Summaries for Smallpox

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MedlinePlus:37 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards based summary: Smallpox, also known as ordinary smallpox, is related to variola minor and variola major, and has symptoms including exanthema and pruritus. An important gene associated with Smallpox is IL18R1 (Interleukin 18 Receptor 1), and among its related pathways are Hypertrophy Model and Immune response_IL-12 signaling pathway. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are digestive/alimentary and neoplasm.

Disease Ontology:11 A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:70 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Related Diseases for Smallpox

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Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1variola minor32.1IFNG, IL2, IL4, TNF
2variola major11.8
3cowpox11.4
4vaccinia11.2
5monkeypox11.2
6viral infectious disease10.8
7panner disease10.6IFNG, TNF
8baetz-greenwalt syndrome10.6IFNG, TNF
9myoclonus epilepsy10.5IFNG, IL4
10autoimmune pancreatitis10.5IFNG, TNF
11bulbospinal polio10.5IFNG, IL2
12linitis plastica10.5IL2, TNF
13steatorrhea10.5IFNG, IL18, TNF
14eye accommodation disease10.5IFNG, IL4
15ehlers-danlos syndrome, musculocontractural type10.5IFNG, IL18R1, TNF
16leukoplakia10.5IL18, IL18R1, TNF
17pneumoconiosis due to talc10.5IL18R1, TNF
18anthracosilicosis10.5IFNG, IL2
19keratosis10.4IFNG, IL18, TNF
20sternum lymphoma10.4IFNG, IL18, TNF
216q terminal deletion syndrome10.4IL4, TNF
22motor peripheral neuropathy10.4IFNG, IL4
23midline interhemispheric variant of holoprosencephaly10.4IL18, IL2
24nut allergy10.4IFNG, IL4
25primary systemic mycosis10.4IFNG, TNF
26maligant granulosa cell tumor of ovary10.4IL2, TNF
27graft-versus-host disease, protection against10.4IFNG, IL2, TNF
28addison's disease10.4IFNG, IL2, TNF
29potter's syndrome10.4IFNG, IL2, TNF
30bolivian hemorrhagic fever10.4IFNG, IL2, TNF
31visual snow syndrome10.4IL2, IL4
32thelaziasis10.4IFNG, IL4
33lacrimal system cancer10.4IFNG, IL2, TNF
34louping ill10.4IFNG, IL2, TNF
35heart leiomyosarcoma10.4IFNG, IL2, TNF
36gastric ulcer10.4IFNG, IL2, TNF
37basidiobolomycosis10.4IL4, TNF
38toxic maculopathy10.3IFNG, IL2, TNF
39paralytic lagophthalmos10.3IL4, TNF
40alternating exotropia10.3IFNG, IL2, TNF
41benign renovascular hypertension10.3IFNG, IL2, TNF
42hepatitis b10.3IFNG, IL18, TNF
43central pontine myelinolysis10.3IFNG, IL2, TNF
44gonococcal synovitis10.3IFNG, IL4, TNF
45lymphocytic colitis10.3IFNG, IL4, TNF
46primary orthostatic tremor10.3IFNG, IL4, TNF
47meninges hemangiopericytoma10.3IFNG, IL4, TNF
48orbital lymphangioma10.3IFNG, IL4, TNF
49scn8a encephalopathy10.3IFNG, IL4, TNF
50atrichia with papular lesions10.3IFNG, IL4, TNF

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Symptoms for Smallpox

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UMLS symptoms related to Smallpox:


exanthema, pruritus

Drugs & Therapeutics for Smallpox

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Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 3, Phase 2, Phase 16428
2Rho(D) Immune GlobulinPhase 4, Phase 2, Phase 1317
3ImmunoglobulinsPhase 4, Phase 2, Phase 16045
4Immunoglobulins, IntravenousPhase 4, Phase 2, Phase 1324
5gamma-GlobulinsPhase 4, Phase 2, Phase 1317
6AntibodiesPhase 4, Phase 2, Phase 16045
7
BenzocaineapprovedPhase 1, Phase 218921994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
8
Glycerolexperimental, approvedPhase 222356-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
9
Phenolapproved, experimentalPhase 245108-95-2996
Synonyms:
Acide carbolique
Acide phenique
Anbesol
Benzenol
Benzophenol
Campho-phenique cold sore gel
Campho-phenique gel
Campho-phenique liquid
Carbolic acid
Carbolic acid liquid
Carbolic oil
Carbolicum acidum
Carbolsaeure
Carbolsaure
Cepastat lozenges
Cuticura pain relieving ointment
Fenol
Fenolo
Fenosmolin
Fenosmoline
Hydroxy-benzene
Hydroxybenzene
IPH
IZAL
Karbolsaeure
Liquefied phenol
Liquid phenol
Liquified phenol
 
Monohydroxy benzene
Monohydroxybenzene
Monophenol
Oxybenzene
PHOH
Paoscle
Phenic
Phenic Acid
Phenic acid
Phenic alcohol
Phenol
Phenol alcohol
Phenol homopolymer
Phenol liquid
Phenol molten
Phenol polymer-bound
Phenol solution
Phenol synthetic
Phenolated water
Phenolated water for disinfection
Phenole
Phenosmolin
Phenyl alcohol
Phenyl hydroxide
Phenylic Acid
Phenylic acid
Phenylic alcohol
Synthetic phenol
Tea polyphenol
10tannic acidapproved, NutraceuticalPhase 1, Phase 21892
11
Mannitolapproved, investigationalPhase 126869-65-8453, 6251
Synonyms:
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
(L)-Mannitol
1,2,3,4,5,6-Hexanehexol
123897-58-5
133-43-7
15719_ALDRICH
15719_RIEDEL
33440_RIEDEL
33440_SIGMA
36413-61-3
4-01-00-02841 (Beilstein Handbook Reference)
5149-40-6
63559_FLUKA
63559_SIGMA
63560_FLUKA
63565_FLUKA
63565_SIGMA
69-65-8
75398-80-0
85085-15-0
87-78-5
AB1002081
AC-12776
AC1L1M49
AC1Q28E5
AI3-19511
AR-1J3861
Ambap69-65-8
BRN 1721898
C00392
C6H14O6
CCRIS 369
CHEBI:16899
CHEMBL689
CID6251
Cordycepate
Cordycepic acid
D-(-)-Mannitol
D-Mannitol
D-Mannitol (JP15)
D-mannite
D-mannitol
D00062
D008353
DL-Mannitol
Diosmol
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
EINECS 200-711-8
EINECS 201-770-2
Fraxinine
HSDB 714
Hexahydroxyhexane
Hexanhexol
Invenex
Isotol
LS-1588
LS-89250
M0044
M1902_SIGMA
M4125_SIAL
M8429_SIAL
M9546_SIAL
M9647_SIAL
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
 
MANNITOL 25%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
MLS001335977
MLS001335978
MTL
Manicol
Manitol
Maniton S
Maniton-S
Manna Sugar
Manna sugar
Mannazucker
Mannidex
Mannidex 16700
Mannigen
Mannistol
Mannit
Mannit p
Mannite
Mannitol
Mannitol (USP)
Mannitol (VAN)
Mannitol 10%
Mannitol 10% In Plastic Container
Mannitol 15%
Mannitol 15% In Plastic Container
Mannitol 20%
Mannitol 20% In Plastic Container
Mannitol 5%
Mannitol 5% In Plastic Container
Mannitol [USAN]
Mannitolum
Mannogem 2080
Marine Crystal
Marine crystal
MolPort-003-927-039
Mushroom sugar
NCGC00164246-01
NCI-C50362
NSC 407017
NSC 9256
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
Osmitrol
Osmitrol (TN)
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
Osmitrol 5% In Water
Osmofundin
Osmosal
Resectisol
Resectisol In Plastic Container
SDM No. 35
SMR000857324
SORBITOL-MANNITOL IN PLASTIC CONTAINER
Sorbitol-Mannitol
TL806434
UNII-3OWL53L36A
ZINC02041302
bmse000099
cpd without stereochemical designation
e 421
e-421
e421
manita
mannitol
12Carboxymethylcellulose SodiumPhase 1172
13Liver ExtractsPhase 13868
14Keyhole-limpet hemocyaninPhase 145
15Radiation-Protective AgentsPhase 1466
16Gastrointestinal AgentsPhase 18109
17Poly ICLCPhase 177
18Poly I-CPhase 166
19LaxativesPhase 1520
20CatharticsPhase 1520
21Interferon InducersPhase 1285
22Anti-Bacterial AgentsPhase 110884
23Adjuvants, ImmunologicPhase 12484
24Pharmaceutical SolutionsPhase 17793
25Protective AgentsPhase 17190
26Antibiotics, AntitubercularPhase 16972
27KrestinPhase 1202
28Anti-Infective AgentsPhase 121402
29interferonsPhase 12137
30Antiviral AgentsPhase 19732
31Natriuretic AgentsPhase 11645
32diureticsPhase 11372
33Interferon-gamma145

Interventional clinical trials:

(show top 50)    (show all 82)
idNameStatusNCT IDPhase
1Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)CompletedNCT00928577Phase 4
2Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV)CompletedNCT01158157Phase 4
3Safety Surveillance Study of ACAM2000® Vaccinia VaccineRecruitingNCT00927719Phase 4
4VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIVRecruitingNCT02443623Phase 4
5VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia InfectionEnrolling by invitationNCT01374984Phase 4
6Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy VolunteersCompletedNCT01317238Phase 3
7Safety and Efficacy of CJ Smallpox Vaccine in Healthy VolunteersCompletedNCT01056770Phase 3
8A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve SubjectsCompletedNCT01144637Phase 3
9Safety and Efficacy of CJ-50300 in Healthy VolunteersCompletedNCT00607243Phase 2, Phase 3
10A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000®Active, not recruitingNCT01913353Phase 3
11A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound TecovirimatActive, not recruitingNCT02474589Phase 3
12IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the CongoNot yet recruitingNCT02977715Phase 3
13Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated VolunteersUnknown statusNCT00103584Phase 1, Phase 2
14Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationCompletedNCT00053495Phase 2
15Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated AdultsCompletedNCT00053482Phase 2
16A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain)CompletedNCT00998543Phase 2
17Dressing Preparations for SmallpoxCompletedNCT00063856Phase 1, Phase 2
18Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox VaccineCompletedNCT00466245Phase 2
19Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young AdultsCompletedNCT00258947Phase 2
20APSV in Vaccinia Naive AdultsCompletedNCT00050518Phase 2
21A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated AdultsCompletedNCT00026611Phase 2
22Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.CompletedNCT00189956Phase 2
23A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced SubjectsCompletedNCT00857493Phase 2
24A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy SubjectsCompletedNCT01668537Phase 2
25A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy SubjectsCompletedNCT00316524Phase 2
26Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®CompletedNCT01827371Phase 2
27MVA Post-Event: Administration Timing and Boost StudyCompletedNCT00437021Phase 1, Phase 2
28Expanded Dryvax Dilution Study in Previously Vaccinated AdultsCompletedNCT00050505Phase 2
29Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered IntradermallyCompletedNCT00914732Phase 2
30ACAM 3000 MVA at Harvard Medical SchoolCompletedNCT00133575Phase 1, Phase 2
31Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected PatientsCompletedNCT00316589Phase 2
32A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic DermatitisCompletedNCT00316602Phase 2
33Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected PatientsCompletedNCT00189904Phase 1, Phase 2
34Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOTCompletedNCT00038987Phase 1, Phase 2
35High Dose IMVAMUNE® in Vaccinia-Naive IndividualsCompletedNCT00879762Phase 2
36Dryvax Dilution-Prev Vacc AdultsCompletedNCT00032708Phase 2
37An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 VaccineesCompletedNCT00686582Phase 2
38Evaluation and Treatment of Eye Complications of Vaccinia VaccinationCompletedNCT00081835Phase 2
39Immune Response to Yellow Fever Vaccination in Adults With Atopic DermatitisCompletedNCT00723489Phase 1, Phase 2
40A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria ParasitesCompletedNCT00890760Phase 1, Phase 2
41PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate CancerCompletedNCT00005916Phase 2
42Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246CompletedNCT00907803Phase 2
43Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV InfectionActive, not recruitingNCT02038881Phase 2
44Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL)Active, not recruitingNCT01266083Phase 2
45Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationTerminatedNCT00053508Phase 2
46Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in AdultsCompletedNCT00079820Phase 1
47Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax®CompletedNCT00042094Phase 1
48Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive SubjectsCompletedNCT00189969Phase 1
49Human Immune Responses SmallpoxCompletedNCT00068198Phase 1
50Safety and Immunogenicity of CJ-50300CompletedNCT00336635Phase 1

Search NIH Clinical Center for Smallpox


Cochrane evidence based reviews: smallpox

Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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MalaCards organs/tissues related to Smallpox:

35
Skin, T cells, Eye, Testes, Myeloid, Prostate, Liver

FMA organs/tissues related to Smallpox:

17
Skin

Animal Models for Smallpox or affiliated genes

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MGI Mouse Phenotypes related to Smallpox:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4IFNG, IL12RB2, IL18, IL2, IL4, PRKCQ
2MP:00020067.8GZMA, IFNG, IL12RB2, IL2, PRKCQ, TNF
3MP:00053977.7GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2
4MP:00053877.6GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2

Publications for Smallpox

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Articles related to Smallpox:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Estimating the Size of the U.S. Population at Risk of Severe Adverse Events from Replicating Smallpox Vaccine. (27739111)
2016
2
An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data. (27052692)
2016
3
Lessons from a modern review of the smallpox eradication files. (26432815)
2015
4
Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed. (26049005)
2015
5
Vaccination-Related Side Effects, Humoral Immunity, and Adverse Events during the Civilian Smallpox Vaccination Campaign, Arkansas, 2003. (26043870)
2015
6
John Fewster and smallpox vaccination--author's reply. (26827388)
2015
7
John Fewster and smallpox vaccination. (26827387)
2015
8
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000(Ar) compared with Dryvax(Ar). (23571177)
2013
9
The utility of smallpox vaccine scars in the forensic identification process. (24174273)
2013
10
Evaluation of a non-viral vaccine in smallpox-vaccinated individuals and immunized HLA-transgenic mice. (22504409)
2012
11
Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults. (22829644)
2012
12
Activity, specificity, and probe design for the smallpox virus protease K7L. (23012361)
2012
13
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
14
Lessons from smallpox eradication campaign in Bihar state and in India. (22486977)
2011
15
Mucosal immunization induces a higher level of lasting neutralizing antibody response in mice by a replication-competent smallpox vaccine: vaccinia Tiantan strain. (21765641)
2011
16
Cowpox virus infection of cynomolgus macaques as a model of hemorrhagic smallpox. (21840027)
2011
17
Effectiveness assessment of countermeasures against bioterrorist smallpox attacks in Japan using an individual-based model. (19784718)
2010
18
Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination. (21209900)
2010
19
Killing a killer: what next for smallpox? (20126444)
2010
20
A Canada-Brazil network in the global eradication of smallpox. (20524373)
2010
21
Pestilence and power: the smallpox epidemic of 1780a891782 and intertribal relations on the Northern Great Plains. (21140933)
2010
22
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. (19349521)
2009
23
Possible autoimmune reactions following smallpox vaccination: the biologic false positive test for syphilis. (19022322)
2009
24
Phenotypic and genetic diversity of the traditional Lister smallpox vaccine. (19059294)
2009
25
The immunology of smallpox vaccines. (19524427)
2009
26
Catching cowpox: the early spread of smallpox vaccination, 1798-1810. (19329840)
2009
27
Squamous cell carcinoma in situ arising in a smallpox vaccination scar. (18477155)
2008
28
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. (18226434)
2008
29
Smallpox: dispelling the myths. (19142290)
2008
30
Self-reported adverse health events following smallpox vaccination in a large prospective study of US military service members. (18382134)
2008
31
Multifaceted contributions: health workers and smallpox eradication in India. (18813588)
2008
32
Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment. (18083278)
2008
33
A review of the smallpox vaccine adverse events active surveillance system. (18284361)
2008
34
Public health and bioterrorism: renewed threat of anthrax and smallpox. (17485954)
2007
35
Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. (18037545)
2007
36
Strugging to a monumental re-assessing the final phases of the smallpox eradication program in India, 1960-1980. (18450301)
2007
37
Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox. (16804475)
2006
38
Five years after 9/11-fearing smallpox, ... and the vaccine against it. (17033745)
2006
39
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication. (17062162)
2006
40
Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients. (16216396)
2006
41
Immunity and immunological memory following smallpox vaccination. (16824139)
2006
42
Smallpox vaccine injury compensation program: Smallpox (Vaccinia) Vaccine Injury Table. Adoption of interim final rule as final rule with an amendment. (16749217)
2006
43
Clinical and immunological comparison of smallpox vaccine administered to the outer versus the inner upper arms of vaccinia-naive adults. (16421781)
2006
44
Smallpox Vaccine Injury Compensation Program: administrative implementation. Adoption of interim final rule as final rule with amendments. (16749218)
2006
45
Keeping the memory of smallpox virus. (16964577)
2006
46
Stability of diluted smallpox vaccine under simulated clinical conditions. (16005123)
2005
47
HIV and Smallpox. (15919975)
2005
48
Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus). (14604375)
2003
49
Separate worlds set to collide: smallpox, vaccinia virus vaccination, and human immunodeficiency virus and acquired immunodeficiency syndrome. (12884168)
2003
50
The survival of smallpox virus (variola minor) in natural circumstances. (4299528)
1968

Variations for Smallpox

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Expression for genes affiliated with Smallpox

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Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

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Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathwaysScoreTop Affiliating Genes
19.9IFNG, IL18
2
Show member pathways
9.6IFNG, IL12RB2, IL18R1
39.6IFNG, IL18, TNF
49.6IFNG, IL18, TNF
59.6IFNG, IL18, TNF
69.6IFNG, IL18, TNF
79.6IFNG, IL2, TNF
89.6IFNG, IL2, TNF
99.5IFNG, IL12RB2, IL2
109.4IFNG, IL2, IL4
119.4IFNG, IL2, IL4
129.4IFNG, IL2, IL4
139.4IFNG, IL18, IL18R1, IL2
149.1IFNG, IL2, IL4, TNF
159.1IFNG, IL2, IL4, TNF
169.1IFNG, IL2, IL4, TNF
179.1IL18, IL2, IL4, TNF
18
Show member pathways
9.1IFNG, IL18, IL18R1, IL2, TNF
199.0IFNG, IL12RB2, IL2, IL4
20
Show member pathways
9.0GZMA, IFNG, IL2, TNF
219.0IL18, IL2, PRKCQ
22
Show member pathways
8.9IFNG, IL18, IL18R1, IL2, IL4
23
Show member pathways
8.8IFNG, IL18, IL2, IL4, TNF
24
Show member pathways
8.7IFNG, IL2, PRKCQ, TNF
25
Show member pathways
8.7IFNG, IL12RB2, IL18, IL18R1, IL2, TNF
26
Show member pathways
8.3IFNG, IL2, IL4, PRKCQ, TNF
27
Show member pathways
8.3IFNG, IL2, IL4, PRKCQ, TNF
28
Show member pathways
8.3IFNG, IL2, IL4, PRKCQ, TNF
29
Show member pathways
8.2IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
30
Show member pathways
8.0GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2
31
Show member pathways
8.0IFNG, IL18, IL2, IL4, PRKCQ, TNF
327.9GZMA, IFNG, IL12RB2, IL18, IL2, IL4
337.8GZMA, IFNG, IL2, IL4, PRKCQ, TNF
34
Show member pathways
7.7IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
35
Show member pathways
7.7IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
36
Show member pathways
7.7IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
37
Show member pathways
7.4IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
38
Show member pathways
7.4IFNG, IL12RB2, IL18, IL18R1, IL2, IL4

GO Terms for genes affiliated with Smallpox

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Cellular components related to Smallpox according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1IFNG, IL12RB2, IL4, TNF

Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:003410510.5IL18, IL2
2positive regulation of vitamin D biosynthetic processGO:006055710.5IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
5type 2 immune responseGO:004209210.3IL18, IL4
6positive regulation of mononuclear cell migrationGO:007167710.3IL4, TNF
7positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL4
8defense response to protozoanGO:004283210.2IFNG, IL4
9negative regulation of growth of symbiont in hostGO:004413010.1IFNG, TNF
10natural killer cell activationGO:003010110.1IL18, IL18R1, IL2
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.1IL2, IL4
12positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, IL4, TNF
13positive regulation of T cell differentiationGO:004558210.0IL2, IL4
14positive regulation of activated T cell proliferationGO:00421049.9IL18, IL2, IL4
15positive regulation of isotype switching to IgG isotypesGO:00483049.9IFNG, IL2, IL4
16positive regulation of interleukin-17 productionGO:00327409.6IL18, IL2, PRKCQ
17positive regulation of interferon-gamma productionGO:00327299.4IL12RB2, IL18, IL18R1, IL2, TNF
18positive regulation of NF-kappaB import into nucleusGO:00423469.3IL18, IL18R1, PRKCQ, TNF
19immune responseGO:00069558.7GZMA, IL18, IL18R1, IL2, IL4
20positive regulation of T cell proliferationGO:00421028.3IFNG, IL2, IL4, PRKCQ

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.8IFNG, IL18, IL2, IL4, TNF

Sources for Smallpox

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet