MCID: SML019
MIFTS: 54

Smallpox malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Smallpox

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Aliases & Descriptions for Smallpox:

Name: Smallpox 11 48 50 38 2 39 13 68
Ordinary Smallpox 11
 
Variola 48

Classifications:



External Ids:

Disease Ontology11 DOID:8736
ICD1030 B03
ICD9CM32 050, 050.9
MeSH39 D012899
NCIt45 C35027

Summaries for Smallpox

About this section
MedlinePlus:38 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards based summary: Smallpox, also known as ordinary smallpox, is related to hepatitis and tularemia, and has symptoms including exanthema, fever and pruritus. An important gene associated with Smallpox is MKX (Mohawk Homeobox), and among its related pathways are Immune response_IL-12 signaling pathway and MSP-RON Signaling. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are digestive/alimentary and neoplasm.

CDC:2 Thousands of years ago, variola virus (smallpox virus) emerged and began causing illness and deaths in human populations, with smallpox outbreaks occurring from time to time. Thanks to the success of vaccination, the last natural outbreak of smallpox in the United States occurred in 1949. In 1980, the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since. 

Disease Ontology:11 A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:71 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Related Diseases for Smallpox

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Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis29.5IFNG, IL2, TNF
2tularemia29.5IFNG, IL2, IL4, TNF
3tuberculosis29.3IL2, IL4, TNF
4variola major11.7
5cowpox11.4
6variola minor11.4
7vaccinia11.2
8monkeypox11.2
9viral infectious disease10.7
10tau syndrome10.3IL18, TNF
11myoglobinuria recurrent10.3IFNG, IL4
12glucose intolerance10.2IFNG, IL18, TNF
13leydig cell hypoplasia10.2IL18, IL18R1, TNF
14steatitis10.2IL2, TNF
15asymptomatic neurosyphilis10.2IFNG, IL4
16benign eccrine breast spiradenoma10.2IFNG, IL18, TNF
17tubular renal disease-cardiomyopathy syndrome10.2IL4, TNF
18geniculate ganglionitis10.2IFNG, IL18, TNF
19stocco dos santos syndrome10.2IFNG, TNF
20severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.2IFNG, IL2, TNF
21plantar wart10.2IFNG, IL2, TNF
22amyotrophic lateral sclerosis type 1410.2IFNG, IL2, TNF
23parametritis10.2IFNG, IL2, TNF
24cyclosporiasis10.2IFNG, IL2, TNF
25venezuelan hemorrhagic fever10.2IFNG, IL2, TNF
26strawberry gallbladder10.2IFNG, IL2, TNF
27urethral intrinsic sphincter deficiency10.2IFNG, IL4, TNF
28hypotrichosis 410.2IFNG, IL4, TNF
29osteodysplasty precocious of danks mayne and kozlowski10.2IFNG, IL4, TNF
30neurotic disorder10.2IFNG, IL4, TNF
31mansonelliasis10.2IFNG, IL2, TNF
32ectodermal dysplasia bartalos type10.2IFNG, IL4, TNF
33oral cavity cancer10.1IFNG, IL4, TNF
34periodontosis10.1IFNG, IL2, TNF
35anterior foramen magnum meningioma10.1IFNG, IL2, TNF
36motor peripheral neuropathy10.1IFNG, IL4, TNF
37lagophthalmos10.1IL4, TNF
38status epilepticus10.1IFNG, IL4, TNF
39balkan nephropathy10.1IFNG, IL4, TNF
40multiple epiphyseal dysplasia due to collagen 9 anomaly10.1IFNG, IL2, IL4
41deafness, autosomal recessive 6710.1IFNG, IL12RB2, IL18, TNF
42parasitic protozoa infectious disease10.1IFNG, IL4, TNF
43hallucinogen dependence10.1IFNG, IL4, TNF
44anus leiomyosarcoma10.1IFNG, IL2, TNF
45keratomalacia10.1IFNG, IL4, TNF
46central nervous system origin vertigo10.1IFNG, IL2, IL4
47sarcoma10.1IL2, IL4
48pulmonary tuberculosis10.1IFNG, IL4, TNF
49retinal ischemia10.1IFNG, IL18, IL2, TNF
50mast-cell leukemia10.1IFNG, IL4, TNF

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Symptoms & Phenotypes for Smallpox

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UMLS symptoms related to Smallpox:


exanthema, fever, pruritus

MGI Mouse Phenotypes related to Smallpox according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9IFNG, IL12RB2, IL18, IL2, IL4, PRKCQ
2MP:00020068.8GZMA, IFNG, IL12RB2, IL2, PRKCQ, TNF
3MP:00053897.3GOLGA3, IFNG, IL2, IL4, PRKCQ, SPIRE1

Drugs & Therapeutics for Smallpox

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Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1VaccinesPhase 4, Phase 3, Phase 2, Phase 16611
2Rho(D) Immune GlobulinPhase 4, Phase 2, Phase 1326
3ImmunoglobulinsPhase 4, Phase 2, Phase 16394
4Immunoglobulins, IntravenousPhase 4, Phase 2, Phase 1333
5gamma-GlobulinsPhase 4, Phase 2, Phase 1326
6AntibodiesPhase 4, Phase 2, Phase 16394
7
BenzocaineapprovedPhase 1, Phase 220161994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
8
Glycerolexperimental, approvedPhase 223856-81-5753
Synonyms:
1,2,3-Trihydroxypropane
1,2,3-propanetriol
1,2,3-trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerin, anhydrous
Glycerin,anhydrous
Glycerine
Glycerinum
 
Glyceritol
Glycerol
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Monoctanoin component D
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
9
Phenolapproved, experimentalPhase 249108-95-2996
Synonyms:
Acide carbolique
Acide phenique
Anbesol
Benzenol
Benzophenol
Campho-phenique cold sore gel
Campho-phenique gel
Campho-phenique liquid
Carbolic acid
Carbolic acid liquid
Carbolic oil
Carbolicum acidum
Carbolsaeure
Carbolsaure
Cepastat lozenges
Cuticura pain relieving ointment
Fenol
Fenolo
Fenosmolin
Fenosmoline
Hydroxy-benzene
Hydroxybenzene
IPH
IZAL
Karbolsaeure
Liquefied phenol
Liquid phenol
Liquified phenol
 
Monohydroxy benzene
Monohydroxybenzene
Monophenol
Oxybenzene
PHOH
Paoscle
Phenic
Phenic Acid
Phenic acid
Phenic alcohol
Phenol
Phenol alcohol
Phenol homopolymer
Phenol liquid
Phenol molten
Phenol polymer-bound
Phenol solution
Phenol synthetic
Phenolated water
Phenolated water for disinfection
Phenole
Phenosmolin
Phenyl alcohol
Phenyl hydroxide
Phenylic Acid
Phenylic acid
Phenylic alcohol
Synthetic phenol
Tea polyphenol
10tannic acidapproved, NutraceuticalPhase 1, Phase 22016
11
Mannitolapproved, investigationalPhase 128069-65-8453, 6251
Synonyms:
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
(L)-Mannitol
1,2,3,4,5,6-Hexanehexol
123897-58-5
133-43-7
15719_ALDRICH
15719_RIEDEL
33440_RIEDEL
33440_SIGMA
36413-61-3
4-01-00-02841 (Beilstein Handbook Reference)
5149-40-6
63559_FLUKA
63559_SIGMA
63560_FLUKA
63565_FLUKA
63565_SIGMA
69-65-8
75398-80-0
85085-15-0
87-78-5
AB1002081
AC-12776
AC1L1M49
AC1Q28E5
AI3-19511
AR-1J3861
Ambap69-65-8
BRN 1721898
C00392
C6H14O6
CCRIS 369
CHEBI:16899
CHEMBL689
CID6251
Cordycepate
Cordycepic acid
D-(-)-Mannitol
D-Mannitol
D-Mannitol (JP15)
D-mannite
D-mannitol
D00062
D008353
DL-Mannitol
Diosmol
ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
EINECS 200-711-8
EINECS 201-770-2
Fraxinine
HSDB 714
Hexahydroxyhexane
Hexanhexol
Invenex
Isotol
LS-1588
LS-89250
M0044
M1902_SIGMA
M4125_SIAL
M8429_SIAL
M9546_SIAL
M9647_SIAL
MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
 
MANNITOL 25%
MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
MLS001335977
MLS001335978
MTL
Manicol
Manitol
Maniton S
Maniton-S
Manna Sugar
Manna sugar
Mannazucker
Mannidex
Mannidex 16700
Mannigen
Mannistol
Mannit
Mannit p
Mannite
Mannitol
Mannitol (USP)
Mannitol (VAN)
Mannitol 10%
Mannitol 10% In Plastic Container
Mannitol 15%
Mannitol 15% In Plastic Container
Mannitol 20%
Mannitol 20% In Plastic Container
Mannitol 5%
Mannitol 5% In Plastic Container
Mannitol [USAN]
Mannitolum
Mannogem 2080
Marine Crystal
Marine crystal
MolPort-003-927-039
Mushroom sugar
NCGC00164246-01
NCI-C50362
NSC 407017
NSC 9256
OSMITROL 10% IN WATER IN PLASTIC CONTAINER
OSMITROL 15% IN WATER IN PLASTIC CONTAINER
OSMITROL 20% IN WATER IN PLASTIC CONTAINER
OSMITROL 5% IN WATER IN PLASTIC CONTAINER
Osmitrol
Osmitrol (TN)
Osmitrol 10% In Water
Osmitrol 15% In Water
Osmitrol 20% In Water
Osmitrol 5% In Water
Osmofundin
Osmosal
Resectisol
Resectisol In Plastic Container
SDM No. 35
SMR000857324
SORBITOL-MANNITOL IN PLASTIC CONTAINER
Sorbitol-Mannitol
TL806434
UNII-3OWL53L36A
ZINC02041302
bmse000099
cpd without stereochemical designation
e 421
e-421
e421
manita
mannitol
12Carboxymethylcellulose SodiumPhase 1185
13Liver ExtractsPhase 14067
14Keyhole-limpet hemocyaninPhase 145
15Radiation-Protective AgentsPhase 1480
16Gastrointestinal AgentsPhase 18402
17Poly ICLCPhase 181
18Poly I-CPhase 171
19LaxativesPhase 1537
20CatharticsPhase 1537
21Interferon InducersPhase 1294
22Anti-Bacterial AgentsPhase 111226
23Adjuvants, ImmunologicPhase 12554
24Pharmaceutical SolutionsPhase 18192
25Protective AgentsPhase 17443
26Antibiotics, AntitubercularPhase 17180
27KrestinPhase 1210
28Anti-Infective AgentsPhase 122062
29interferonsPhase 12175
30Antiviral AgentsPhase 19967
31Natriuretic AgentsPhase 11697
32diureticsPhase 11418
33Interferon-gamma152

Interventional clinical trials:

(show top 50)    (show all 82)
idNameStatusNCT IDPhase
1Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)CompletedNCT00928577Phase 4
2Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV)CompletedNCT01158157Phase 4
3VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIVRecruitingNCT02443623Phase 4
4VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia InfectionEnrolling by invitationNCT01374984Phase 4
5Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy VolunteersCompletedNCT01317238Phase 3
6Safety and Efficacy of CJ Smallpox Vaccine in Healthy VolunteersCompletedNCT01056770Phase 3
7A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve SubjectsCompletedNCT01144637Phase 3
8Safety and Efficacy of CJ-50300 in Healthy VolunteersCompletedNCT00607243Phase 2, Phase 3
9A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound TecovirimatCompletedNCT02474589Phase 3
10IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the CongoRecruitingNCT02977715Phase 3
11A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000®Active, not recruitingNCT01913353Phase 3
12Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated VolunteersUnknown statusNCT00103584Phase 1, Phase 2
13Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationCompletedNCT00053495Phase 2
14Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated AdultsCompletedNCT00053482Phase 2
15A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain)CompletedNCT00998543Phase 2
16Dressing Preparations for SmallpoxCompletedNCT00063856Phase 1, Phase 2
17Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox VaccineCompletedNCT00466245Phase 2
18Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young AdultsCompletedNCT00258947Phase 2
19APSV in Vaccinia Naive AdultsCompletedNCT00050518Phase 2
20A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated AdultsCompletedNCT00026611Phase 2
21Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.CompletedNCT00189956Phase 2
22A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced SubjectsCompletedNCT00857493Phase 2
23A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy SubjectsCompletedNCT01668537Phase 2
24A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy SubjectsCompletedNCT00316524Phase 2
25Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®CompletedNCT01827371Phase 2
26MVA Post-Event: Administration Timing and Boost StudyCompletedNCT00437021Phase 1, Phase 2
27Expanded Dryvax Dilution Study in Previously Vaccinated AdultsCompletedNCT00050505Phase 2
28Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered IntradermallyCompletedNCT00914732Phase 2
29ACAM 3000 MVA at Harvard Medical SchoolCompletedNCT00133575Phase 1, Phase 2
30Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected PatientsCompletedNCT00316589Phase 2
31A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic DermatitisCompletedNCT00316602Phase 2
32Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected PatientsCompletedNCT00189904Phase 1, Phase 2
33Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOTCompletedNCT00038987Phase 1, Phase 2
34High Dose IMVAMUNE® in Vaccinia-Naive IndividualsCompletedNCT00879762Phase 2
35Dryvax Dilution-Prev Vacc AdultsCompletedNCT00032708Phase 2
36An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 VaccineesCompletedNCT00686582Phase 2
37Evaluation and Treatment of Eye Complications of Vaccinia VaccinationCompletedNCT00081835Phase 2
38Immune Response to Yellow Fever Vaccination in Adults With Atopic DermatitisCompletedNCT00723489Phase 1, Phase 2
39A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria ParasitesCompletedNCT00890760Phase 1, Phase 2
40PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate CancerCompletedNCT00005916Phase 2
41Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246CompletedNCT00907803Phase 2
42Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV InfectionActive, not recruitingNCT02038881Phase 2
43Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL)Active, not recruitingNCT01266083Phase 2
44Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationTerminatedNCT00053508Phase 2
45Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in AdultsCompletedNCT00079820Phase 1
46Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax®CompletedNCT00042094Phase 1
47Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive SubjectsCompletedNCT00189969Phase 1
48Human Immune Responses SmallpoxCompletedNCT00068198Phase 1
49Safety and Immunogenicity of CJ-50300CompletedNCT00336635Phase 1
50A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated VolunteersCompletedNCT00002261Phase 1

Search NIH Clinical Center for Smallpox


Cochrane evidence based reviews: smallpox

Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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MalaCards organs/tissues related to Smallpox:

36
Skin, T cells, Testes, B cells, Eye, Breast, Brain

FMA organs/tissues related to Smallpox:

17
Skin

Publications for Smallpox

About this section

Articles related to Smallpox:

(show top 50)    (show all 634)
idTitleAuthorsYear
1
Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations. (28046039)
2017
2
Use of Vaccinia Virus Smallpox Vaccine in Laboratory and Health Care Personnel at Risk for Occupational Exposure to Orthopoxviruses - Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2015. (26985679)
2016
3
Long-term safety of replication-defective smallpox vaccine (MVA-BN) in atopic eczema and allergic rhinitis. (27357167)
2016
4
A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox. (28003603)
2016
5
Smallpox and Dracunculiasis: The Scientific Value of Infectious Diseases That Have Been Eradicated or Targeted for Eradication. Is Schistosomiasis Next? (26741130)
2016
6
17(th) Century Variola Virus Reveals the Recent History of Smallpox. (27939314)
2016
7
Adventures of a Female Medical Detective: In Pursuit of Smallpox and AIDS. (27402821)
2016
8
Ectromelia Virus Disease Characterization in the BALB/c Mouse: A Surrogate Model for Assessment of Smallpox Medical Countermeasures. (27455306)
2016
9
Bob H. Reinhardt: The End of A Global Pox. America and the Eradication of Smallpox in the Cold War Era : The University of North Carolina Press, Chapel Hill, 2015, 268 pp., Hard cover, Illustrated, Figure, Maps, Table, Notes, Bibliography, Index., $39.95. (28040839)
2016
10
Formulation and characterization of ternary inclusion complex containing hydroxypropyl-I^-cyclodextrin and meglumine for solubility enhancement of poorly water-soluble ST-246, an anti-smallpox drug. (27697036)
2016
11
Estimating the Size of the U.S. Population at Risk of Severe Adverse Events from Replicating Smallpox Vaccine. (27739111)
2016
12
Estimated prevalence of smallpox vaccine contraindications in Israeli adolescents. (27206387)
2016
13
Smallpox in the post eradication era. (27209648)
2016
14
Urban inoculation and the decline of smallpox mortality in eighteenth-century cities-a reply to Razzell. (26900169)
2016
15
Defending against smallpox: a focus on vaccines. (27049653)
2016
16
Modelling and Bayesian analysis of the Abakaliki smallpox data. (28038869)
2016
17
Povidone Iodine Ointment Application to the Vaccination Site Does Not Alter Immunoglobulin G Antibody Response to Smallpox Vaccine. (27214505)
2016
18
DA Henderson, Smallpox Eradicator. (27715298)
2016
19
Vaccinations against smallpox and tuberculosis are associated with better long-term survival: a Danish case-cohort study 1971-2010. (27380797)
2016
20
History of Smallpox and Its Spread in Human Populations. (27726788)
2016
21
Buccal viral DNA as a trigger for brincidofovir therapy in the mousepox model of smallpox. (28039021)
2016
22
Erratum: Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial. (26949713)
2016
23
Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972. (27999233)
2016
24
New effective chemically synthesized anti-smallpox compound NIOCH-14. (26861777)
2016
25
Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox. (26889021)
2016
26
Position on reproductive donors andA smallpox vaccine: a committee opinion. (26829211)
2016
27
An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data. (27052692)
2016
28
A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BNAr) in 56-80-Year-Old Subjects. (27327616)
2016
29
A New Document on Smallpox Vaccination. (28010829)
2016
30
The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. (27513748)
2016
31
Genome Sequence of Vaccinia virus Strain Lister-Butantan, a Lister Vaccine Variant Used during a Smallpox Eradication Campaign in Brazil. (27340056)
2016
32
Impaired innate, humoral, and cellular immunity despite a take in smallpox vaccine recipients. (27177944)
2016
33
Repeated high-dose (5 A9 10(8)TCID50) toxicity study, of a third generation smallpox vaccine (IMVAMUNE), in New Zealand white rabbits. (26836234)
2016
34
The prevention and eradication of smallpox: a commentary on Sloane (1755) 'An account of inoculation'. (25750241)
2015
35
Smallpox in the Medici family, Florence, 1519-1737: a historical cohort study. (25677626)
2015
36
Smallpox, Anthrax, and the Historiography of Cutaneous Diseases. (26650656)
2015
37
The efficacy and pharmacokinetics of brincidofovir for the treatment of lethal rabbitpox virus infection: A model of smallpox disease. (25746331)
2015
38
Immunomodulator-based enhancement of anti smallpox immune responses. (25875833)
2015
39
Smallpox Vaccination of Laboratory Workers at US Variola Testing Sites. (26196153)
2015
40
Lessons from a modern review of the smallpox eradication files. (26432815)
2015
41
Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial. (26380340)
2015
42
Preparedness for a smallpox pandemic in Japan: public health perspectives. (26060873)
2015
43
Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus. (26195812)
2015
44
Cowpox Helped Against Smallpox; Will the Goat Lentivirus (Caprine Arthritis Encephalitis Virus) Help Against HIV-1? (25844817)
2015
45
Modernizing stockpiles of medical countermeasures against smallpox: Benefits, risks, and knowledge gaps. (26312493)
2015
46
Control, containment and health education in the smallpox-vaccination campaigns in Mexico in the 1940s. (26038851)
2015
47
Sex difference in immune response to vaccination: A participant-level meta-analysis of randomized trials of IMVAMUNE(Ar) smallpox vaccine. (26319063)
2015
48
George Washington and Smallpox: A Revolutionary Hero and Public Health Activist. (25739090)
2015
49
Clinical guidance for smallpox vaccine use in a postevent vaccination program. (25695372)
2015
50
Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed. (26049005)
2015

Variations for Smallpox

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Expression for genes affiliated with Smallpox

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Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

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Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6IFNG, IL12RB2, IL18R1
29.6IFNG, IL18, TNF
39.6IFNG, IL18, TNF
49.6IFNG, IL18, TNF
59.6IFNG, IL18, TNF
69.5IL18, IL2, PRKCQ
79.5IL18, IL4, TNF
89.5IL18, IL4, TNF
99.4IFNG, IL2, TNF
109.4IFNG, IL2, TNF
11
Show member pathways
9.4IFNG, IL2, TNF
129.4IFNG, IL2, TNF
139.4IFNG, IL12RB2, IL2
149.3IFNG, IL2, IL4
159.3IFNG, IL2, IL4
169.3IFNG, IL2, IL4
179.2IFNG, IL18, IL18R1, IL2
18
Show member pathways
9.2IFNG, IL2, PRKCQ, TNF
199.1IFNG, IL18, IL4, TNF
209.0IL18, IL2, IL4, TNF
219.0IFNG, IL2, IL4, TNF
229.0IFNG, IL2, IL4, TNF
239.0IFNG, IL2, IL4, TNF
24
Show member pathways
9.0IFNG, IL2, IL4, TNF
258.9IFNG, IL12RB2, IL2, IL4
26
Show member pathways
8.9IFNG, IL12RB2, IL2, IL4
27
Show member pathways
8.9IFNG, IL18, IL18R1, IL2, TNF
28
Show member pathways
8.7IFNG, IL2, IL4, PRKCQ, TNF
29
Show member pathways
8.7IFNG, IL2, IL4, PRKCQ, TNF
30
Show member pathways
8.7IFNG, IL2, IL4, PRKCQ, TNF
31
Show member pathways
8.7IFNG, IL18, IL2, IL4, TNF
32
Show member pathways
8.6IFNG, IL12RB2, IL18, IL18R1, IL2, TNF
33
Show member pathways
8.6GZMA, IFNG, IL2, TNF
34
Show member pathways
8.4IFNG, IL18, IL2, IL4, PRKCQ, TNF
35
Show member pathways
8.3IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
36
Show member pathways
8.3IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
37
Show member pathways
8.2GZMA, IL2, IL4, PRKCQ, TNF
38
Show member pathways
8.2IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
39
Show member pathways
7.9IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
40
Show member pathways
7.9IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
41
Show member pathways
7.9IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
427.9GZMA, IFNG, IL2, IL4, PRKCQ, TNF
43
Show member pathways
7.6GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2
447.6GZMA, IFNG, IL12RB2, IL18, IL2, IL4
45
Show member pathways
7.5IFNG, IL12RB2, IL18, IL18R1, IL2, IL4

GO Terms for genes affiliated with Smallpox

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Cellular components related to Smallpox according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1IFNG, IL12RB2, IL4, TNF

Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1interleukin-18-mediated signaling pathwayGO:003565510.7IL18, IL18R1
2negative regulation of growth of symbiont in hostGO:004413010.5IFNG, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
5positive regulation of mononuclear cell migrationGO:007167710.3IL4, TNF
6positive regulation of NF-kappaB import into nucleusGO:004234610.3IL18, IL18R1, TNF
7positive regulation of MHC class II biosynthetic processGO:004534810.3IFNG, IL4
8positive regulation of tissue remodelingGO:003410510.3IL18, IL2
9negative regulation of T-helper 17 cell differentiationGO:200032010.3IL2, IL4
10natural killer cell activationGO:003010110.2IL18, IL18R1, IL2
11positive regulation of interleukin-17 productionGO:003274010.2IL18, IL2, PRKCQ
12positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, IL4, TNF
13positive regulation of activated T cell proliferationGO:004210410.0IL18, IL2, IL4
14positive regulation of vitamin D biosynthetic processGO:006055710.0IFNG, TNF
15positive regulation of isotype switching to IgG isotypesGO:00483049.9IFNG, IL2, IL4
16positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8IL2, IL4
17type 2 immune responseGO:00420929.8IL18, IL4
18positive regulation of interferon-gamma productionGO:00327299.6IL12RB2, IL18, IL18R1, IL2, TNF
19positive regulation of protein phosphorylationGO:00019349.5IFNG, IL2, IL4, TNF
20positive regulation of T cell proliferationGO:00421029.5IFNG, IL2, IL4, PRKCQ
21positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.4IFNG, IL18, IL2, IL4
22immune responseGO:00069558.3GZMA, IFNG, IL18, IL18R1, IL2, IL4

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7IFNG, IL18, IL2, IL4, TNF

Sources for Smallpox

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet