MCID: SML019
MIFTS: 56

Smallpox malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Smallpox

About this section

Aliases & Descriptions for Smallpox:

Name: Smallpox 10 45 47 12 36 35 2 65
Ordinary Smallpox 10
 
Variola 45

Classifications:



External Ids:

Disease Ontology10 DOID:8736
ICD1027 B03
ICD9CM29 050, 050.9
MeSH36 D012899
NCIt42 C35027
UMLS65 C0037354

Summaries for Smallpox

About this section
MedlinePlus:35 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards based summary: Smallpox, also known as ordinary smallpox, is related to variola major and vaccinia, and has symptoms including pruritusand exanthema. An important gene associated with Smallpox is IL18R1 (Interleukin 18 Receptor 1), and among its related pathways are Hypertrophy Model and Malaria. Affiliated tissues include skin, skin and breast, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Disease Ontology:10 A viral infectious disease that results in infection located in skin, has material basis in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:68 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Related Diseases for Smallpox

About this section

Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1variola major11.5
2vaccinia11.0
3monkeypox10.8
4cowpox10.8
5variola minor10.7
6anotia10.6IL18, IL2
7autoimmune oophoritis10.6IFNG, TNF
8spinal polio10.6IFNG, IL2
9ureterocele10.5IL2, TNF
10non-distal monosomy 10q10.5IFNG, TNF
11cycloplegia10.5IFNG, IL4
12graft-versus-host disease, protection against10.5IFNG, IL2
13ethmoid sinus squamous cell carcinoma10.5IFNG, TNF
14siderosis10.5IL18R1, TNF
15hairy cell leukemia of spleen10.5IFNG, IL12RB2, IL18R1
16primary progressive freezing gait10.5IL4, TNF
17parasitic ichthyosporea infectious disease10.5IFNG, TNF
18brucella melitensis brucellosis10.4IL2, TNF
19kearns-sayre syndrome10.4IL4, TNF
20chronic tic disorder10.4IFNG, IL18, TNF
21dioctophymiasis10.4IFNG, IL4
22cow milk allergy10.4IFNG, IL18, IL4
23blackwater fever10.4IFNG, IL18, TNF
24achalasia10.4IL4, TNF
25argentine hemorrhagic fever10.3IFNG, IL2, TNF
26cryoglobulinemia10.3IFNG, IL2, TNF
27byssinosis10.3IFNG, IL2, TNF
28opisthorchiasis10.3IFNG, TNF
29limbic encephalitis with ncmags antibodies10.3IFNG, IL2, IL4
30baylisascariasis10.3IL2, IL4
31colon sarcoma10.3IFNG, IL2, TNF
32chronic demyelinizing neuropathy with igm monoclonal10.3IFNG, IL2
33miliary tuberculosis10.3IFNG, IL2, TNF
34vulvovaginitis10.3IFNG, IL2, IL4
35acute gonococcal epididymo-orchitis10.3IFNG, IL2, TNF
36epididymis cancer10.3IL2, IL4
37gonococcal bursitis10.3IFNG, IL4, TNF
38early-onset, autosomal dominant alzheimer disease10.3IFNG, IL4, TNF
39cll/sll10.3IFNG, IL2, TNF
40central nervous system melanocytic neoplasm10.3IFNG, IL4, TNF
41soft palate cancer10.3IFNG, IL4, TNF
42meige syndrome10.2IFNG, IL4, TNF
43orbital plasma cell granuloma10.2IFNG, IL2, IL4
44cd45 deficiency10.2IL2, IL4
45hodgkin's lymphoma, lymphocytic-histiocytic predominance10.2IFNG, IL2, IL4
46blastomycosis10.2IFNG, IL4, TNF
47acute orbital inflammation10.2IFNG, IL4, TNF
48neurogenic bladder10.2IFNG, IL2, TNF
49reflex sympathetic dystrophy10.2IFNG, IL4, TNF
50alpha 1-antitrypsin deficiency10.2IL18, IL2, IL4

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Symptoms for Smallpox

About this section

UMLS symptoms related to Smallpox:


pruritus, exanthema

Drugs & Therapeutics for Smallpox

About this section

Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunologic FactorsPhase 4, Phase 3, Phase 2, Phase 118483
2Rho(D) Immune GlobulinPhase 4206
3ImmunoglobulinsPhase 4, Phase 2, Phase 14477
4Immunoglobulins, IntravenousPhase 4211
5AntibodiesPhase 4, Phase 2, Phase 14477
6VaccinesPhase 4, Phase 3, Phase 2, Phase 16085
7
Phenolapproved, experimentalPhase 243108-95-2996
Synonyms:
Acide carbolique
Acide phenique
Anbesol
Aseptil Rojo
Benzenol
Benzophenol
Campho-phenique cold sore gel
Campho-phenique gel
Campho-phenique liquid
Carbolic acid
Carbolic acid liquid
Carbolic oil
Carbolicum acidum
Carbolsaeure
Carbolsaure
Care One Sore Throat
Castellani Paint
Castellani Paint 1.5%
Cepastat Cherry
Cepastat Extra Strength
Cepastat lozenges
Chloraseptic Sore Throat
Chloraseptic Sore Throat Cherry
Chloraseptic Sore Throat Citrus
Chloraseptic Sore Throat Menthol
Chloraseptic Warming Sore Throat
Cuticura pain relieving ointment
Dg Health Sore Throat
Equaline Sore Throat
Equate Sore Throat
Fenol
Fenolo
Fenosmolin
Fenosmoline
Good Neighbor Pharmacy Sore Throat
Good Sense Sore Throat
Healthy Accents Sore Throat
Hydroxy-benzene
Hydroxybenzene
IPH
IZAL
Karbolsaeure
Leader Sore Throat
Liquefied phenol
Liquid phenol
 
Liquified phenol
Monohydroxy benzene
Monohydroxybenzene
Monophenol
Oral Relief
Oxybenzene
PHOH
Paoscle
Phenic
Phenic Acid
Phenic acid
Phenic alcohol
Phenol
Phenol alcohol
Phenol homopolymer
Phenol liquid
Phenol molten
Phenol polymer-bound
Phenol solution
Phenol synthetic
Phenolated water
Phenolated water for disinfection
Phenole
Phenosmolin
Phenyl alcohol
Phenyl hydroxide
Phenylic Acid
Phenylic acid
Phenylic alcohol
Rx Act Sore Throat
Smart Sense Sore Throat
Sore Throat
Sore Throat Cherry
Sore Throat Menthol
Sore Throat ReadyInCase
Sore Throat Relief
Sore Throat Relief Cherry
Sore Throat Spray
Sore Throat Spray Cherry
Sore Throat cherry
Sore Throat spray
Sunmark Sore Throat
Synthetic phenol
Tea polyphenol
Throat Relief
Topcare Sore Throat
8
BenzocaineapprovedPhase 1, Phase 216841994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
9
GlycerolexperimentalPhase 219156-81-5753
Synonyms:
1,2,3-Trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerine
Glyceritol
Glycerol
 
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
10tannic acidNutraceuticalPhase 1, Phase 21684
11Liver ExtractsPhase 13572
12Adjuvants, ImmunologicPhase 11783
13Keyhole-limpet hemocyaninPhase 143
14Pharmaceutical SolutionsPhase 17004
15Poly ICLCPhase 168
16interferonsPhase 11930
17KrestinPhase 1189
18Antiviral AgentsPhase 18071
19Anti-Infective Agents17220
20Interferon-gamma137

Interventional clinical trials:

(show top 50)    (show all 81)
idNameStatusNCT IDPhase
1Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)CompletedNCT00928577Phase 4
2Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV)CompletedNCT01158157Phase 4
3Safety Surveillance Study of ACAM2000® Vaccinia VaccineRecruitingNCT00927719Phase 4
4VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIVRecruitingNCT02443623Phase 4
5VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia InfectionEnrolling by invitationNCT01374984Phase 4
6Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy VolunteersCompletedNCT01317238Phase 3
7Safety and Efficacy of CJ Smallpox Vaccine in Healthy VolunteersCompletedNCT01056770Phase 3
8A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve SubjectsCompletedNCT01144637Phase 3
9Safety and Efficacy of CJ-50300 in Healthy VolunteersCompletedNCT00607243Phase 2, Phase 3
10A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound TecovirimatRecruitingNCT02474589Phase 3
11A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000®RecruitingNCT01913353Phase 3
12Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated AdultsCompletedNCT00053482Phase 2
13Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationCompletedNCT00053495Phase 2
14Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young AdultsCompletedNCT00258947Phase 2
15Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox VaccineCompletedNCT00466245Phase 2
16A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain)CompletedNCT00998543Phase 2
17ACAM 3000 MVA at Harvard Medical SchoolCompletedNCT00133575Phase 1, Phase 2
18Dressing Preparations for SmallpoxCompletedNCT00063856Phase 1, Phase 2
19APSV in Vaccinia Naive AdultsCompletedNCT00050518Phase 2
20Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered IntradermallyCompletedNCT00914732Phase 2
21A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated AdultsCompletedNCT00026611Phase 2
22A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy SubjectsCompletedNCT00316524Phase 2
23Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.CompletedNCT00189956Phase 2
24A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced SubjectsCompletedNCT00857493Phase 2
25A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy SubjectsCompletedNCT01668537Phase 2
26MVA Post-Event: Administration Timing and Boost StudyCompletedNCT00437021Phase 1, Phase 2
27Expanded Dryvax Dilution Study in Previously Vaccinated AdultsCompletedNCT00050505Phase 2
28Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®CompletedNCT01827371Phase 2
29A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic DermatitisCompletedNCT00316602Phase 2
30Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOTCompletedNCT00038987Phase 1, Phase 2
31Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected PatientsCompletedNCT00316589Phase 2
32High Dose IMVAMUNE® in Vaccinia-Naive IndividualsCompletedNCT00879762Phase 2
33Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected PatientsCompletedNCT00189904Phase 1, Phase 2
34Dryvax Dilution-Prev Vacc AdultsCompletedNCT00032708Phase 2
35Evaluation and Treatment of Eye Complications of Vaccinia VaccinationCompletedNCT00081835Phase 2
36An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 VaccineesCompletedNCT00686582Phase 2
37Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246CompletedNCT00907803Phase 2
38Immune Response to Yellow Fever Vaccination in Adults With Atopic DermatitisCompletedNCT00723489Phase 1, Phase 2
39A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria ParasitesCompletedNCT00890760Phase 1, Phase 2
40PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate CancerCompletedNCT00005916Phase 2
41Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV InfectionActive, not recruitingNCT02038881Phase 2
42Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated VolunteersActive, not recruitingNCT00103584Phase 1, Phase 2
43Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL)Active, not recruitingNCT01266083Phase 2
44Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationTerminatedNCT00053508Phase 2
45Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in AdultsCompletedNCT00079820Phase 1
46Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax®CompletedNCT00042094Phase 1
47A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated VolunteersCompletedNCT00002261Phase 1
48Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive SubjectsCompletedNCT00189969Phase 1
49Human Immune Responses SmallpoxCompletedNCT00068198Phase 1
50Safety and Immunogenicity of CJ-50300CompletedNCT00336635Phase 1

Search NIH Clinical Center for Smallpox


Cochrane evidence based reviews: smallpox

Genetic Tests for Smallpox

About this section

Anatomical Context for Smallpox

About this section

MalaCards organs/tissues related to Smallpox:

33
Skin, Breast, Lung, T cells, Brain, Prostate, Thyroid

FMA organs/tissues related to Smallpox:

16
Skin

Animal Models for Smallpox or affiliated genes

About this section

MGI Mouse Phenotypes related to Smallpox:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IFNG, IL12RB2, IL2, IRF1, PRKCQ, TNF
2MP:00053818.1IFNG, IL12RB2, IL18, IL2, IL4, PRKCQ
3MP:00053797.7GOLGA3, IFNG, IL12RB2, IL2, IL4, IRF1
4MP:00053977.2IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
5MP:00053876.9IFNG, IL12RB2, IL18, IL18R1, IL2, IL4

Publications for Smallpox

About this section

Articles related to Smallpox:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Lessons from a modern review of the smallpox eradication files. (26432815)
2015
2
Modeling the Effect of Herd Immunity and Contagiousness in Mitigating a Smallpox Outbreak. (25480757)
2014
3
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000(Ar) compared with Dryvax(Ar). (23571177)
2013
4
Evaluation of a non-viral vaccine in smallpox-vaccinated individuals and immunized HLA-transgenic mice. (22504409)
2012
5
Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults. (22829644)
2012
6
The discontinuation of routine smallpox vaccination in the United States, 1960-1976: an unlikely affirmation of biomedical hegemony. (21340322)
2011
7
Smallpox and its eradication in the Democratic Republic of Congo: lessons learned. (22188930)
2011
8
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
9
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses. (21235430)
2011
10
Proceedings of a symposium: Smallpox Eradication after 30 Years: Lessons, Legacies and Innovations, August 24-27, 2010, Rio de Janeiro, Brazil. (22860253)
2011
11
Smallpox eradication, laboratory visits, and a touch of tourism: travel notes of a Canadian scientist in Brazil. (21461539)
2010
12
A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge. (20659519)
2010
13
Effectiveness assessment of countermeasures against bioterrorist smallpox attacks in Japan using an individual-based model. (19784718)
2010
14
ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile. (20531961)
2010
15
Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination. (21209900)
2010
16
Killing a killer: what next for smallpox? (20126444)
2010
17
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. (19349521)
2009
18
Possible autoimmune reactions following smallpox vaccination: the biologic false positive test for syphilis. (19022322)
2009
19
Pursuing protection from disease: the making of smallpox prophylactic practice in colonial Punjab. (19329846)
2009
20
Responding to suspected smallpox cases in the Los Angeles County from 2002 to 2006: identifying areas for education. (19041534)
2009
21
Phenotypic and genetic diversity of the traditional Lister smallpox vaccine. (19059294)
2009
22
Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. (18923431)
2009
23
Squamous cell carcinoma in situ arising in a smallpox vaccination scar. (18477155)
2008
24
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. (18226434)
2008
25
Smallpox: dispelling the myths. (19142290)
2008
26
Self-reported adverse health events following smallpox vaccination in a large prospective study of US military service members. (18382134)
2008
27
US Civilian Smallpox Preparedness and Response Program, 2003. (18284355)
2008
28
Follow-up of cardiovascular adverse events after smallpox vaccination among civilians in the United States, 2003. (18284366)
2008
29
Multifaceted contributions: health workers and smallpox eradication in India. (18813588)
2008
30
Public health and bioterrorism: renewed threat of anthrax and smallpox. (17485954)
2007
31
Safety, immunogenicity and protective efficacy in mice of a new cell-cultured Lister smallpox vaccine candidate. (17964011)
2007
32
Transcriptional interactions during smallpox infection and identification of early infection biomarkers. (17992748)
2007
33
Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. (18037545)
2007
34
Comparison of military and civilian reporting rates for smallpox vaccine adverse events. (17154344)
2007
35
The immunogenetics of smallpox vaccination. (17570108)
2007
36
Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox. (16804475)
2006
37
Mass vaccination and surveillance/containment in the eradication of smallpox. (16989262)
2006
38
Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain. (16139395)
2006
39
Five years after 9/11-fearing smallpox, ... and the vaccine against it. (17033745)
2006
40
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication. (17062162)
2006
41
Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety. (16965588)
2006
42
Smallpox antiviral drug development: satisfying the animal efficacy rule. (16597208)
2006
43
Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients. (16216396)
2006
44
Immunity and immunological memory following smallpox vaccination. (16824139)
2006
45
Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus. (15951823)
2005
46
A population survey of smallpox knowledge, perceptions, and healthcare-seeking behavior surrounding the Iraq invasion--Connecticut 2002-03. (16181047)
2005
47
Stability of diluted smallpox vaccine under simulated clinical conditions. (16005123)
2005
48
Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus). (14604375)
2003
49
Human monkeypox and smallpox viruses: genomic comparison. (11734207)
2001
50
The survival of smallpox virus (variola minor) in natural circumstances. (4299528)
1968

Variations for Smallpox

About this section

Expression for genes affiliated with Smallpox

About this section
Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

About this section

Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathwaysScoreTop Affiliating Genes
19.9IFNG, IL18
29.6IFNG, IL18, TNF
39.6IFNG, IL18, TNF
49.6IFNG, IL18, TNF
59.6IFNG, IL18, TNF
69.5IFNG, IL12RB2, IL2
79.5IFNG, IL2, TNF
8
Show member pathways
9.5IFNG, IL2, TNF
99.5IFNG, IL2, TNF
109.4IFNG, IL2, IL4
119.4IFNG, IL2, IL4
129.3IL18, IL2, PRKCQ
139.3IFNG, IL2, IRF1
14
Show member pathways
9.2IFNG, IL12RB2, IL18R1, IRF1
159.1IFNG, IL12RB2, IL2, IL4
16
Show member pathways
9.1IFNG, IL12RB2, IL2, IL4
179.1IFNG, IL2, IL4, TNF
189.1IFNG, IL2, IL4, TNF
199.1IFNG, IL2, IL4, TNF
20
Show member pathways
9.0IFNG, IL18, IL18R1, IL2, TNF
21
Show member pathways
9.0IFNG, IL2, PRKCQ, TNF
228.9IFNG, IL2, IL4, IRF1
23
Show member pathways
8.9IFNG, IL4, IRF1, TNF
248.8IFNG, IL18, IL18R1, IL2, IRF1
25
Show member pathways
8.7IFNG, IL12RB2, IL18, IL18R1, IL2, TNF
26
Show member pathways
8.7IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
27
Show member pathways
8.5IFNG, IL2, IL4, PRKCQ, TNF
28
Show member pathways
8.5IFNG, IL2, IL4, PRKCQ, TNF
29
Show member pathways
8.5IFNG, IL2, IL4, PRKCQ, TNF
308.5IFNG, IL12RB2, IL18, IL2, IL4, TNF
31
Show member pathways
8.3IL2, IL4, IRF1, PRKCQ, TNF
32
Show member pathways
8.3IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
33
Show member pathways
8.3IFNG, IL18, IL2, IL4, IRF1, TNF
34
Show member pathways
8.3IFNG, IL18, IL2, IL4, PRKCQ, TNF
35
Show member pathways
8.0IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
36
Show member pathways
8.0IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
37
Show member pathways
7.7IFNG, IL12RB2, IL18, IL18R1, IL2, IL4

GO Terms for genes affiliated with Smallpox

About this section

Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:003410510.6IL18, IL2
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IFNG, TNF
3positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IFNG, TNF
4natural killer cell activationGO:003010110.4IL18, IL2
5defense response to protozoanGO:004283210.4IFNG, IL4
6type 2 immune responseGO:004209210.4IL18, IL4
7positive regulation of mononuclear cell migrationGO:007167710.3IL4, TNF
8negative regulation of growth of symbiont in hostGO:004413010.3IFNG, TNF
9positive regulation of T cell differentiationGO:004558210.3IL2, IL4
10extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.3IL2, IL4
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.3IL2, IL4
12protein import into nucleus, translocationGO:000006010.3IFNG, TNF
13positive regulation of NF-kappaB import into nucleusGO:004234610.2PRKCQ, TNF
14positive regulation of osteoclast differentiationGO:004567210.2IFNG, TNF
15positive regulation of MHC class II biosynthetic processGO:004534810.2IFNG, IL4
16positive regulation of chemokine biosynthetic processGO:004508010.0IFNG, IL4, TNF
17positive regulation of interleukin-17 productionGO:003274010.0IL18, IL2, PRKCQ
18positive regulation of isotype switching to IgG isotypesGO:00483049.9IFNG, IL2, IL4
19cell surface receptor signaling pathwayGO:00071669.8IFNG, IL12RB2, TNF
20positive regulation of interferon-gamma productionGO:00327299.6IL12RB2, IL18, IL2, TNF
21positive regulation of T cell proliferationGO:00421029.4IFNG, IL2, IL4, PRKCQ
22positive regulation of protein phosphorylationGO:00019349.4IL2, IL4, TNF
23positive regulation of transcription from RNA polymerase II promoterGO:00459448.5IFNG, IL2, IL4, IRF1, TNF
24immune responseGO:00069558.5IFNG, IL18, IL18R1, IL2, IL4, TNF

Sources for Smallpox

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet