MCID: SML019
MIFTS: 43

Smallpox malady

Infectious diseases category

Summaries for Smallpox

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards: Smallpox, also known as ordinary smallpox, is related to vaccinia and hepatitis. An important gene associated with Smallpox is HLA-A (major histocompatibility complex, class I, A). The compound endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:63 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Aliases & Classifications for Smallpox

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

smallpox 8 42 10 44 33 60
ordinary smallpox 8
variola 42


External Ids:

Disease Ontology8 DOID:8736
ICD9CM27 050.9, 050
MeSH34 D012899
NCIt39 C35027
ICD1025 B03

Related Diseases for Smallpox

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Clinical Features for Smallpox

About this section

Drugs & Therapeutics for Smallpox

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Smallpox

Drug clinical trials:

Search ClinicalTrials for Smallpox

Search NIH Clinical Center for Smallpox

Search CenterWatch for Smallpox

Genetic Tests for Smallpox

About this section

Anatomical Context for Smallpox

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Smallpox:

32
Skin, T cells, Testes, Brain, Eye, Breast, B cells

FMA organs/tissues related to Smallpox:

14
Skin

Animal Models for Smallpox or affiliated genes

About this section

Publications for Smallpox

About this section
Sources:
50PubMed
See all sources

Articles related to Smallpox:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000(Ar) compared with Dryvax(Ar). (23571177)
2013
2
Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox). (24100494)
2013
3
A brief history of vaccines: smallpox to the present. (23444589)
2013
4
Activity, specificity, and probe design for the smallpox virus protease K7L. (23012361)
2012
5
Genome-wide association study of antibody response to smallpox vaccine. (22542470)
2012
6
Guidelines for smallpox vaccination for health care workers. (22340808)
2012
7
Contact transmission of vaccinia virus from smallpox vaccinees in the United States, 2003-2011. (22192851)
2012
8
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
9
The strategic use of novel smallpox vaccines in the post-eradication world. (21806397)
2011
10
Images of health. Smallpox: the first vaccine. (21566041)
2011
11
Establishment of the black-tailed prairie dog (Cynomys ludovicianus) as a novel animal model for comparing smallpox vaccines administered preexposure in both high- and low-dose monkeypox virus challenges. (21632764)
2011
12
Breaking the deadlock over destruction of the smallpox virus stocks. (21219134)
2011
13
Multivalent smallpox DNA vaccine delivered by intradermal electroporation drives protective immunity in nonhuman primates against lethal monkeypox challenge. (21148501)
2011
14
A personal recollection of smallpox eradication with the benefit of hindsight: in commemoration of 30th anniversary. (21266748)
2011
15
Smallpox variolation during the revolutionary war. (21709598)
2011
16
Countermeasures and vaccination against terrorism using smallpox: pre-event and post-event smallpox vaccination and its contraindications. (21431786)
2011
17
Serological responses in humans to the smallpox vaccine LC16m8. (21715598)
2011
18
Experiences with smallpox eradication in Ethiopia. (22486979)
2011
19
A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge. (20659519)
2010
20
Insights from the structure of a smallpox virus topoisomerase-DNA transition state mimic. (20152159)
2010
21
An active participant in the eradication program of smallpox. (20586232)
2010
22
A brief history of smallpox eradication in Iran. (20039774)
2010
23
The 1727 St Kilda epidemic: smallpox or chickenpox? (20608348)
2009
24
The smallpox vaccine induces an early neutralizing IgM response. (19822230)
2009
25
Multifaceted contributions: health workers and smallpox eradication in India. (18813588)
2008
26
A review of the smallpox vaccine adverse events active surveillance system. (18284361)
2008
27
Persistence of vaccinia at the site of smallpox vaccination. (18171221)
2008
28
Performance of an algorithm for assessing smallpox risk among patients with rashes that may be confused with smallpox. (18284359)
2008
29
Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of Dryvax. (17977963)
2008
30
Ridding London of smallpox: the aerial transmission debate and the evolution of a precautionary approach. (18325128)
2008
31
Smallpox vaccine. A tame virus runs amok. (17556562)
2007
32
Proteome-wide analysis of the serological response to vaccinia and smallpox. (17443847)
2007
33
Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. (17715329)
2007
34
Tail scarification with Vaccinia virus Lister as a model for evaluation of smallpox vaccine potency in mice. (17928110)
2007
35
Mass vaccination and surveillance/containment in the eradication of smallpox. (16989262)
2006
36
Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients. (16216396)
2006
37
Transmission patterns of smallpox: systematic review of natural outbreaks in Europe and North America since World War II. (16677388)
2006
38
"Lo! The poor Indian!" colonial responses to the 1862-63 smallpox epidemic in British Columbia and Vancouver Island. (17214129)
2006
39
Vaccinia DNA in blood after smallpox vaccination. (16985223)
2006
40
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. (16341204)
2006
41
Performance of serological assays used to test blood from recent smallpox vaccinees. (17002644)
2006
42
Smallpox transmission and control: spatial dynamics in Great Britain. (16894173)
2006
43
Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine. (16337719)
2006
44
Generalized vaccinia, progressive vaccinia, and eczema vaccinatum are rare following smallpox (vaccinia) vaccination: United States surveillance, 2003. (16080092)
2005
45
Hospital decision-making regarding the smallpox pre-event vaccination program. (15853452)
2005
46
Treatment for complications of smallpox vaccination. (16130204)
2005
47
Comparison of clinical presentation of acute myocarditis following smallpox vaccination to acute coronary syndromes in patients <40 years of age. (15878006)
2005
48
Stevens-Johnson syndrome after immunization with smallpox, anthrax, and tetanus vaccines. (15357044)
2004
49
Biological agents as weapons 1: smallpox and botulism. (12056996)
2002
50
The first smallpox epidemic on the Canadian Plains: In the fur-traders' words. (18159275)
2000

Genetic Variations for Smallpox

About this section

Expression for genes affiliated with Smallpox

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Smallpox

Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

About this section

Compounds for genes affiliated with Smallpox

About this section
Sources:
44Novoseek
See all sources

Compounds related to Smallpox according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1endotoxin4410.6IL18BP, CR1, CCL20

GO Terms for genes affiliated with Smallpox

About this section

Products for genes affiliated with Smallpox

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Smallpox

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet