MCID: SML019
MIFTS: 42

Smallpox malady

Rare diseases, Infectious diseases, Skin diseases categories
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Summaries for Smallpox

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards: Smallpox, also known as ordinary smallpox, is related to cowpox and influenza. An important gene associated with Smallpox is TKT (transketolase). The compound endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:65 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Aliases & Classifications for Smallpox

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Skin diseases


Aliases & Descriptions:

smallpox 8 43 10 45 34 62
ordinary smallpox 8
variola 43


External Ids:

Disease Ontology8 DOID:8736
ICD9CM27 050.9, 050
NCIt40 C35027
MeSH35 D012899
ICD1025 B03

Related Diseases for Smallpox

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Smallpox via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1cowpox30.8TKT, IL18BP
2influenza30.2HLA-A, CR1, CCL20
3hepatitis29.9TKT, HLA-A, CR1
4viral infectious disease29.9CCL20, HLA-A, CR1
5vaccinia10.9
6monkeypox10.6
7variola minor10.4
8variola major10.3
9chickenpox10.3
10yellow fever10.2
11folliculitis10.1
12encephalitis10.1
13myocarditis10.1
14blindness10.1
15acquired immunodeficiency syndrome10.1
16dracunculiasis10.1
17botulism10.1
18exanthem10.1
19plague10.1
20tularemia10.1
21headache10.1
22nasopharynx carcinoma10.0HLA-A, TKT
23hematologic cancer10.0TKT, CR1, HLA-A
24chronic kidney failure10.0HLA-A, IL18BP, CR1
25immunodeficiency with hyper igm type 210.0TKT, HLA-A, CR1
26hepatitis c10.0CR1, HLA-A, CCL20
27tuberculosis10.0HLA-A, TKT, CR1
28cystic fibrosis10.0HLA-A, CCL20, CR1
29arthritis10.0HLA-A, CCL20, CR1
30hypersensitivity reaction type ii disease10.0CR1, IL18BP, HLA-A
31galactosemia10.0IL18BP, CCL20, HLA-A, CR1
32venezuelan equine encephalitis10.0
33rheumatoid arthritis10.0TKT, HLA-A, CR1, CCL20, IL18BP
34melanoma10.0IL18BP, TKT, HLA-A, CCL20, CR1
35pancreatic cancer10.0HLA-A, TKT, CCL20
36leukemia10.0TKT, HLA-A, CCL20, CR1
37pityriasis rosea9.9
38cholera9.9
39pharyngitis9.9
40lassa fever9.9
41indeterminate leprosy9.9
42aphthous stomatitis9.9
43scarlet fever9.9
44measles9.9
45cutaneous leiomyosarcoma9.9
46infertility9.9
47erythema multiforme9.9
48post-vaccinal encephalitis9.9
49spongiotic dermatitis9.9
50q fever9.9

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Symptoms for Smallpox

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Drugs & Therapeutics for Smallpox

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Smallpox

Search NIH Clinical Center for Smallpox

Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Smallpox:

33
Skin, T cells, Testes, Eye, Brain, Breast, B cells

FMA organs/tissues related to Smallpox:

14
Skin

Animal Models for Smallpox or affiliated genes

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Publications for Smallpox

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Sources:
52PubMed
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Articles related to Smallpox:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000(Ar) compared with Dryvax(Ar). (23571177)
2013
2
Evaluation of a non-viral vaccine in smallpox-vaccinated individuals and immunized HLA-transgenic mice. (22504409)
2012
3
Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults. (22829644)
2012
4
The discontinuation of routine smallpox vaccination in the United States, 1960-1976: an unlikely affirmation of biomedical hegemony. (21340322)
2011
5
Smallpox and its eradication in the Democratic Republic of Congo: lessons learned. (22188930)
2011
6
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
7
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses. (21235430)
2011
8
Proceedings of a symposium: Smallpox Eradication after 30 Years: Lessons, Legacies and Innovations, August 24-27, 2010, Rio de Janeiro, Brazil. (22860253)
2011
9
Lessons from smallpox eradication campaign in Bihar state and in India. (22486977)
2011
10
Smallpox eradication, laboratory visits, and a touch of tourism: travel notes of a Canadian scientist in Brazil. (21461539)
2010
11
A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge. (20659519)
2010
12
Effectiveness assessment of countermeasures against bioterrorist smallpox attacks in Japan using an individual-based model. (19784718)
2010
13
ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile. (20531961)
2010
14
Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination. (21209900)
2010
15
Killing a killer: what next for smallpox? (20126444)
2010
16
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. (19349521)
2009
17
Possible autoimmune reactions following smallpox vaccination: the biologic false positive test for syphilis. (19022322)
2009
18
Pursuing protection from disease: the making of smallpox prophylactic practice in colonial Punjab. (19329846)
2009
19
Responding to suspected smallpox cases in the Los Angeles County from 2002 to 2006: identifying areas for education. (19041534)
2009
20
Phenotypic and genetic diversity of the traditional Lister smallpox vaccine. (19059294)
2009
21
Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. (18923431)
2009
22
Squamous cell carcinoma in situ arising in a smallpox vaccination scar. (18477155)
2008
23
Smallpox: dispelling the myths. (19142290)
2008
24
Self-reported adverse health events following smallpox vaccination in a large prospective study of US military service members. (18382134)
2008
25
US Civilian Smallpox Preparedness and Response Program, 2003. (18284355)
2008
26
Follow-up of cardiovascular adverse events after smallpox vaccination among civilians in the United States, 2003. (18284366)
2008
27
Multifaceted contributions: health workers and smallpox eradication in India. (18813588)
2008
28
Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment. (18083278)
2008
29
Public health and bioterrorism: renewed threat of anthrax and smallpox. (17485954)
2007
30
Safety, immunogenicity and protective efficacy in mice of a new cell-cultured Lister smallpox vaccine candidate. (17964011)
2007
31
Transcriptional interactions during smallpox infection and identification of early infection biomarkers. (17992748)
2007
32
Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. (18037545)
2007
33
Comparison of military and civilian reporting rates for smallpox vaccine adverse events. (17154344)
2007
34
The immunogenetics of smallpox vaccination. (17570108)
2007
35
Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox. (16804475)
2006
36
Mass vaccination and surveillance/containment in the eradication of smallpox. (16989262)
2006
37
Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain. (16139395)
2006
38
Five years after 9/11-fearing smallpox, ... and the vaccine against it. (17033745)
2006
39
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication. (17062162)
2006
40
Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety. (16965588)
2006
41
Smallpox antiviral drug development: satisfying the animal efficacy rule. (16597208)
2006
42
Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients. (16216396)
2006
43
Immunity and immunological memory following smallpox vaccination. (16824139)
2006
44
Cytokines, skin, and smallpox-a new link to an antimicrobial Peptide. (16546093)
2006
45
Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus. (15951823)
2005
46
A population survey of smallpox knowledge, perceptions, and healthcare-seeking behavior surrounding the Iraq invasion--Connecticut 2002-03. (16181047)
2005
47
Stability of diluted smallpox vaccine under simulated clinical conditions. (16005123)
2005
48
Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus). (14604375)
2003
49
Human monkeypox and smallpox viruses: genomic comparison. (11734207)
2001
50
The survival of smallpox virus (variola minor) in natural circumstances. (4299528)
1968

Variations for Smallpox

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Expression for genes affiliated with Smallpox

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Smallpox

Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

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Compounds for genes affiliated with Smallpox

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45Novoseek
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Compounds related to Smallpox according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1endotoxin459.5CR1, IL18BP, CCL20

GO Terms for genes affiliated with Smallpox

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Products for genes affiliated with Smallpox

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Smallpox

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet