MCID: SML019
MIFTS: 41

Smallpox malady

Infectious category

Summaries for Smallpox

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards: Smallpox, also known as ordinary smallpox, is related to vaccinia and monkeypox. An important gene associated with Smallpox is HLA-A (major histocompatibility complex, class I, A). The compound endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and brain.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:64 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Aliases & Classifications for Smallpox

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

smallpox 8 43 10 45 34 61
ordinary smallpox 8
variola 43


External Ids:

Disease Ontology8 DOID:8736
ICD9CM27 050.9, 050
MeSH35 D012899
NCIt40 C35027
ICD1025 B03

Related Diseases for Smallpox

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Clinical Features for Smallpox

Drugs & Therapeutics for Smallpox

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Smallpox

Drug clinical trials:

Search ClinicalTrials for Smallpox

Search NIH Clinical Center for Smallpox

Search CenterWatch for Smallpox

Genetic Tests for Smallpox

Anatomical Context for Smallpox

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Smallpox:

33
Skin, Brain, Breast, T cells, B cells

FMA organs/tissues related to Smallpox:

14
Skin

Animal Models for Smallpox or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Smallpox

Sources:
51PubMed
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Articles related to Smallpox:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Humoral immunity to smallpox vaccines and monkeypox virus challenge: proteomic assessment and clinical correlations. (23135728)
2013
2
An open-label, single arm, phase III clinical study to evaluate the efficacy and safety of CJ smallpox vaccine in previously vaccinated healthy adults. (24021303)
2013
3
Evaluation of a non-viral vaccine in smallpox-vaccinated individuals and immunized HLA-transgenic mice. (22504409)
2012
4
Outbreaks of human monkeypox after cessation of smallpox vaccination. (22239910)
2012
5
The discontinuation of routine smallpox vaccination in the United States, 1960-1976: an unlikely affirmation of biomedical hegemony. (21340322)
2011
6
Lessons from smallpox eradication campaign in Bihar state and in India. (22486977)
2011
7
Mucosal immunization induces a higher level of lasting neutralizing antibody response in mice by a replication-competent smallpox vaccine: vaccinia Tiantan strain. (21765641)
2011
8
Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors. (21854314)
2011
9
Smallpox should be saved. (21248793)
2011
10
Smallpox eradication after 30 years: lessons, legacies, and innovations. Introduction: meeting objectives, summary and final statement. (22486978)
2011
11
The Emergency campaign for smallpox eradication from Somalia (1977-1979)--revisited. (22185834)
2011
12
A report of 2 cases of myopericarditis after Vaccinia virus (smallpox) immunization. (22324207)
2011
13
Rabbitpox: a model of airborne transmission of smallpox. (20965981)
2011
14
Smallpox eradication and Brazil: an interview with Donald A. Henderson. (21461538)
2010
15
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. (19349521)
2009
16
Catching cowpox: the early spread of smallpox vaccination, 1798-1810. (19329840)
2009
17
Eczema vaccinatum resulting from the transmission of vaccinia virus from a smallpox vaccinee: an investigation of potential fomites in the home environment. (19027813)
2009
18
Comparative evaluation of the immune responses and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model. (19605597)
2009
19
Smallpox vaccines induce antibodies to the immunomodulatory, secreted vaccinia virus complement control protein. (19587131)
2009
20
A tale of two global health programs. Smallpox eradication's lessons for the antipolio campaign in India. (19528668)
2009
21
Encephalitis after secondary smallpox vaccination. (19025490)
2009
22
Human immune memory to yellow fever and smallpox vaccination. (19052852)
2009
23
Extracting key information from historical data to quantify the transmission dynamics of smallpox. (18715509)
2008
24
Clinical and immune response to undiluted and diluted smallpox vaccine. (18654870)
2008
25
A rapid, high-throughput vaccinia virus neutralization assay for testing smallpox vaccine efficacy based on detection of green fluorescent protein. (18387679)
2008
26
Severe eczema vaccinatum in a household contact of a smallpox vaccinee. (18419490)
2008
27
Mapping perceptions related to acceptance of smallpox vaccination by hospital emergency room personnel. (18563995)
2008
28
A contagious journey within a culture of complacency: the smallpox scare of 1962 in New York and Toronto. (18447310)
2007
29
"The people have no more love left for the Commonwealth": Media, migration and identity in the 1961-2 British smallpox outbreak. (20622927)
2007
30
Detailed kinetics of immune responses to a new cell culture-derived smallpox vaccine in vaccinia-naA^ve adults. (17597266)
2007
31
Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox. (16804475)
2006
32
Smallpox antiviral drug development: satisfying the animal efficacy rule. (16597208)
2006
33
Smallpox. (16737112)
2006
34
Regulation of catalysis by the smallpox virus topoisomerase. (17032643)
2006
35
Smallpox vaccination site complications. (16796628)
2006
36
Smallpox during pregnancy and maternal outcomes. (16836830)
2006
37
Smallpox vaccination site reactions: two cases of exaggerated scarring and a brief review. (16796647)
2006
38
Detection of vaccinia DNA in the blood following smallpox vaccination. (16639047)
2006
39
The smallpox vaccine: An update for oral health care professionals. (16637473)
2006
40
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus. (16581912)
2006
41
Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus. (15951823)
2005
42
HIV and Smallpox. (15919975)
2005
43
Smallpox vaccines: circling the wagons. (15889981)
2005
44
If smallpox strikes Portland.... (15859212)
2005
45
Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model. (15993917)
2005
46
Smallpox 2003. (18159463)
2003
47
Eczematous skin disease and recall of past diagnoses: implications for smallpox vaccination. (12834312)
2003
48
Infectious diseases and smallpox politics in New Mexico's Rio Abajo, 1847-1920. (18041170)
2000
49
The British, the Indians, and smallpox: what actually happened at Fort Pitt in 1763? (17216901)
2000
50
Smallpox vaccinia with late interstitial keratitis; a case report. (13478034)
1957

Genetic Variations for Smallpox

Expression for genes affiliated with Smallpox

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Smallpox

Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

Compounds for genes affiliated with Smallpox

Sources:
45Novoseek
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Compounds related to Smallpox according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1endotoxin4510.6IL18BP, CR1, CCL20

GO Terms for genes affiliated with Smallpox

Products for genes affiliated with Smallpox

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Smallpox

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet