Summaries for Smallpox

Sources:
6Disease Ontology, 23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still house small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like and include high fever, fatigue and headache and backache, followed by a rash with flat red sores. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases23

MalaCards: Smallpox, also known as ordinary smallpox, is related to cowpox and viral infectious disease. An important gene associated with Smallpox is IL18BP (interleukin 18 binding protein), and among its related pathways are Th1 Differentiation and Hematopoietic cell lineage. The compounds pge2 and indoleamine have been mentioned in the context of this disorder. Affiliated tissues include skin and skin.

Disease Ontology: A viral infectious disease that results in infection located in skin, has material basis in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.6

Wikipedia: Smallpox was an infectious disease unique to humans, caused by either of two virus variants, Variola...44 more...

Aliases & Descriptions for Smallpox

Sources:
2CDC, 6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 27NCIt, 19ICD9CM, 24MeSH
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Aliases & Descriptions:

smallpox 6 30 8 32 23 43
ordinary smallpox 6
variola 30

External Ids:

ICD9CM19 050.9, 050
SNOMED-CT40 67924001, 266193008, 186505008 154344005, 47452006, more

Related Diseases for Smallpox

Sources:
13GeneCards, 14GeneDecks
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Diseases related to smallpox by text searches and GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1cowpox29.8KLHL2, IL18, IL18BP, ANK1, PTGDR, TWF2
2viral infectious disease25.2CD4, IRF1, IL18, IL18R1, IL4, CCR5
3vaccinia22.3KLHL2, VCP, CD8A, CD4, IL18, IL18BP
4intermediate uveitis13.2CCR5, CXCR3
5chromoblastomycosis13.1IL4, HLA-A, CXCR3
6yellow fever13.1FBXL15, CCR5, PRNT
7contagious pustular dermatitis13.1KLHL2, ANK1, PRODH
8plasmodium falciparum malaria13.1IL18, HLA-A, CR1, ABO
9proliferative glomerulonephritis13.1CCR5, CR1, CXCR3
10aphthous stomatitis13.1CCR5, HLA-A, TKT, CXCR3
11cutaneous lupus erythematosus13.0IL18, HLA-A, CXCR3
12chickenpox13.0CD8A, CD4, DTYMK, DPT
13stevens-johnson syndrome13.0IL4, HLA-A, CXCR3
14malaria13.0IRF1, IL4, CR1, ABO
15molluscum contagiosum12.9CD4, IL18, IL18BP
16behcet's disease12.9IL18, CCR5, HLA-A
17hiv-1, resistance to12.9CD4, CCR5, HLA-A
18echinococcosis12.9CD8A, IL4, HLA-A
19central nervous system disease12.9IL18, CCR5, CXCR3
20mumps12.9CD4, IRF1, IL18R1, DPT
21monkeypox12.9KLHL2, VCP, CYB5R3, TWF2, PRODH
22pulmonary sarcoidosis12.9IL18, CCR5, CXCR3
23dengue hemorrhagic fever12.8IRF1, IL4, HLA-A, PRNT
24adult-onset still's disease12.8CD4, IL18, IL18BP
25hepatitis b12.8IL18, CCR5, CR1
26nervous system disease12.8IL18, CCR5, CXCR3
27primary immunodeficiency disease12.8CD8A, CD4, IL4
28reactive arthritis12.8IL18, IL18R1, CCR5, CR1
29periapical granuloma12.8IL4, CCR5, CXCR3
30keratitis12.8CD4, IL18, CCL20, TKT
31eosinophilic pneumonia12.8IL18, IL4, CXCR3
32crohn's disease12.7IRF1, IL18, IL4, CCL20
33syphilis12.7WARS, CD4, CCR5
34relapsing-remitting multiple sclerosis12.7IL18, IL4, HLA-A, CXCR3
35adult t-cell leukemia12.7CD8A, CD4, IL18R1, CXCR3
36aggressive periodontitis12.6IL18, IL18R1, IL4, HLA-A
37type 1 diabetes mellitus12.6IL18, IL18R1, CCR5, HLA-A, CR1
38lipodystrophy12.6CD4, IL18, IL18BP, HLA-A
39cerebral malaria12.6IL4, CCR5, CR1, CXCR3
40atopic dermatitis12.6CD8A, IL18, IL4, CCL20, CXCR3
41autoimmune thyroiditis12.6IL18, IL4, CCL20, HLA-A, CXCR3
42polymyositis12.5CD8A, IL4, CCR5, HLA-A
43graft versus host disease12.5IL18, IL4, CCR5, HLA-A
44pulmonary plasma cell granuloma12.5CD4, IL18, CXCR3
45tetanus12.5CD8A, CD4, IL4, HLA-A, DPT
46rubella12.5IL18R1, IL4, CCR5, HLA-A, DPT
47pleural tuberculosis12.5IL18, IL4
48peripheral t-cell lymphoma12.5CD8A, CD4, IL4, CCL20, CXCR3
49lymphoproliferative syndrome12.4CD4, IL18R1, CCR5, HLA-A, CXCR3
50lymphopenia12.4CD8A, CD4, IL18, IL4

Graphical network of the top 20 diseases related to smallpox:



Graphical network of diseases related to smallpox

Clinical Features for Smallpox

Drugs & Therapeutics for Smallpox

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for smallpox

Drug clinical trials:

Search ClinicalTrials for smallpox

Search NIH Clinical Center for smallpox

Search CenterWatch for smallpox

Genetic Tests for Smallpox

Anatomical Context for Smallpox

Sources:
11FMA, 22MalaCards
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MalaCards organs/tissues related to smallpox:

22
Skin

FMA organs/tissues related to smallpox:

11
Skin

Phenotypes for genes affiliated with Smallpox

Publications for genes affiliated with Smallpox

Sources:
35PubMed
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Articles related to smallpox:

idTitleAuthorsYearAffiliating Genes
1Common SNPs/haplotypes in IL18R1 and IL18 genes are a ssociated with variations in humoral immunity to smallpox vaccination in Caucas ians and African Americans. (21742843)Haralambieva I.H.... Poland G.A.2011IL18, IL18R1
2Kinetics of serum cytokines after primary or repeat v accination with the smallpox vaccine. (20214479)Cohen J.I.... Hornung R.L.2010CXCR3
3Genetic basis for adverse events after smallpox vaccination. (18454680)Reif D.M.... Crowe J.E.2008IL4, MTHFR, IRF1

Expression for genes affiliated with Smallpox

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Smallpox

Pathways for genes affiliated with Smallpox

Sources:
37R&D Systems, 20KEGG, 36QIAGEN
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Compounds for genes affiliated with Smallpox

Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
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Compounds related to smallpox according to GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1pge232 9.9PTGDR, IRF1, CD4
2indoleamine32 9.9IL18, IRF1, WARS
3flagellin32 9.9CXCR3, CCL20, IL18
4larc32 9.9CCR5, CCL20, CXCR3
5il-1232 9.7CCL20, IL4, IL18
6poly(i-c)32 9.6CCL20, IL4, IL18, IRF1
7c-d4i32 9.6CD4, CCR5
8ccl332 9.5CXCR3, CCL20, CCR5, IL18
9endotoxin32 9.5CXCR3, CR1, CCL20, IL18R1, IL18BP, IL18
10allergens32 9.4CXCR3, CCL20, IL4, IL18
11groalpha32 9.4IL18, CCR5, CXCR3
12zidovudine32 9 9 11.4TKT, DTYMK, CCR5, CD4
13etanercept32 9 9 11.4CXCR3, IL18R1, IL18
14infliximab32 9 9 11.3CXCR3, IL4, IL18R1, IL18
15heparin32 9 18 9 12.2CD4, IL18R1, CR1, CXCR3
16ribavirin32 34 9 9 12.1IL18, IL4, CCR5, CXCR3
17polyinosinic-polycytidylic acid32 9.1IL4, IL18, IRF1
18tacrolimus32 34 9 9 12.1CXCR3, HLA-A, IL4, IL18R1, IL18
19neopterin32 9.0IL4, IL18R1, IL18, CD4
20il 1032 9.0CXCR3, CCR5, IL4, IL18, CD8A
21adenylate32 8.9TKT, CR1, DTYMK, HLA-A, IL4, IL18R1
22polysaccharide32 8.7CR1, CCR5, IL18R1, IL18, CD4, VCP
23glutamine32 8.7TKT, CYB5R3, CCR5, IL18R1, IL18, VCP
24calcium32 9 18 9 11.6CXCR3, CR1, PTGDR, CCL20, IL18R1, IRF1
25tarc32 8.6CD4, CXCR3, CCL20, CCR5, IL4, IL18
26cysteine32 8.1TKT, PLXNC1, CYB5R3, CCR5, IL18R1, CD4
27cyclosporin a32 42 9.1CR1, HLA-A, CCR5, IL4, IL18R1, IL18
28rantes32 8.1CXCR3, CCL20, CCR5, IL4, IL18R1, IL18
29arginine32 7.8CXCR3, ABO, PLXNC1, CYB5R3, HLA-A, CCR5
30thymidine32 18 8.8CXCR3, TKT, CYB5R3, DTYMK, IL4, IL18R1
31alanine32 7.5ABO, HLA-A, CCL20, CCR5, IL18R1, IL18BP
32serine32 6.7CXCR3, TKT, ABO, CYB5R3, CCR5, IL18R1
33tyrosine32 6.5HLA-A, CR1, PLXNC1, TKT, PRODH, CXCR3

GO Terms for genes affiliated with Smallpox

Sources:
12Gene Ontology
See all sources

Cellular components related to smallpox according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.4CD8A, CD4, IL4, CCR5, CXCR3

Biological processes related to smallpox according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to tumor necrosis factorGO:0713569.8IRF1, IL18, IL18BP
2type 2 immune responseGO:0420929.6IL4, IL18
3entry into host cellGO:0302609.4CCR5, CD4
4chemotaxisGO:0069358.8IL4, CCR5, CCL20, CXCR3
5immune responseGO:0069557.9CD8A, HLA-A, CCL20, CCR5, IL4, IL18R1

Molecular functions related to smallpox according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1FAD bindingGO:07194910.0CYB5R3, PRODH
2coreceptor activityGO:0150269.0CD8A, CD4, CCR5

Sources for Smallpox

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS