Aliases & Classifications for Smallpox

MalaCards integrated aliases for Smallpox:

Name: Smallpox 12 72 49 51 40 3 41 14 69
Ordinary Smallpox 12
Variola 49

Classifications:



External Ids:

Disease Ontology 12 DOID:8736
ICD10 32 B03
ICD9CM 34 050 050.9
MeSH 41 D012899
NCIt 46 C35027
UMLS 69 C0037354

Summaries for Smallpox

MedlinePlus : 40 Smallpox is a disease caused by the Variola major virus. Some experts say that over the centuries it has killed more people than all other infectious diseases combined. Worldwide immunization stopped the spread of smallpox three decades ago. The last case was reported in 1977. Two research labs still keep small amounts of the virus. Experts fear bioterrorists could use the virus to spread disease. Smallpox spreads very easily from person to person. Symptoms are flu-like. They include High fever Fatigue Headache Backache A rash with flat red sores There is no treatment. Fluids and medicines for pain or fever can help control symptoms. Most people recover, but some can die. Those who do recover may have severe scars. The U.S. stopped routine smallpox vaccinations in 1972. Military and other high-risk groups continue to get the vaccine. The U.S. has increased its supply of the vaccine in recent years. The vaccine makes some people sick, so doctors save it for those at highest risk of disease. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Smallpox, also known as ordinary smallpox, is related to variola major and viral infectious disease, and has symptoms including pruritus, fever and exanthema. An important gene associated with Smallpox is GPR158 (G Protein-Coupled Receptor 158), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Vaccines and Rho(D) Immune Globulin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results_in infection located in skin, has material basis in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

CDC : 3 Thousands of years ago, variola virus (smallpox virus) emerged and began causing illness and deaths in human populations, with smallpox outbreaks occurring from time to time. Thanks to the success of vaccination, the last natural outbreak of smallpox in the United States occurred in 1949. In 1980, the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since. 

Wikipedia : 72 Smallpox was an infectious disease caused by one of two virus variants, Variola major and Variola minor.... more...

Related Diseases for Smallpox

Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 variola major 33.2 IFNG IL2
2 viral infectious disease 31.3 IFNG IL2 TNF
3 gillessen-kaesbach-nishimura syndrome 30.3 IL18 IL18BP
4 mycobacterium tuberculosis 1 29.7 IFNG IL18 TNF
5 erythema multiforme 29.7 IFNG IL2 TNF
6 schistosomiasis 29.6 IFNG IL2 TNF
7 acquired immunodeficiency syndrome 29.4 CSF2 IFNG IL2 TNF
8 leprosy 3 29.3 IFNG IL12RB2 IL2 TNF
9 dermatitis, atopic 29.3 CSF2 IFNG IL18 IL2 TNF
10 arthritis 29.2 CSF2 IFNG IL18 TNF
11 inflammatory bowel disease 28.8 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
12 cowpox 11.5
13 vaccinia 11.4
14 monkeypox 11.3
15 variola minor 11.2
16 systemic onset juvenile idiopathic arthritis 10.4 IL18 TNF
17 staphylococcal toxic shock syndrome 10.4 IFNG TNF
18 chronic beryllium disease 10.4 IFNG TNF
19 leukomalacia 10.4 IL18 IL18R1 TNF
20 anthracosis 10.4 IL18R1 TNF
21 oral tuberculosis 10.4 IL2 TNF
22 pleural tuberculosis 10.4 IFNG IL18 TNF
23 rasmussen encephalitis 10.4 IFNG IL18 TNF
24 berylliosis 10.4 IFNG IL2
25 melioidosis 10.3 IFNG IL18 TNF
26 penicillin allergy 10.3 IFNG IL18
27 lymphadenitis 10.3 IFNG IL18 TNF
28 autoinflammation, lipodystrophy, and dermatosis syndrome 10.3 IFNG IL18 TNF
29 plasmodium falciparum malaria 10.3 IFNG IL18 TNF
30 relapsing-remitting multiple sclerosis 10.3 IFNG IL18 TNF
31 streptococcal toxic-shock syndrome 10.3 IL2 TNF
32 immune suppression 10.2 IFNG IL2
33 autoimmune myocarditis 10.2 IFNG IL2 TNF
34 clonorchiasis 10.2 IFNG IL2 TNF
35 crohn's colitis 10.2 IFNG IL2 TNF
36 microscopic colitis 10.2 IFNG IL2 TNF
37 posterior uveitis 10.2 IFNG IL2 TNF
38 intermediate uveitis 10.2 IFNG IL2 TNF
39 coccidiosis 10.2 IFNG IL2 TNF
40 hematopoietic stem cell transplantation 10.2 IFNG IL2 TNF
41 hypersensitivity reaction type iv disease 10.2 IFNG IL2 TNF
42 hemophagocytic lymphohistiocytosis 10.2 IFNG IL18 TNF
43 pleurisy 10.2 IFNG IL2 TNF
44 farmer's lung 10.2 IL2 TNF
45 tonsillitis 10.2 IFNG IL2 TNF
46 human immunodeficiency virus infectious disease 10.2 IFNG IL2 TNF
47 spondyloarthropathy 10.2 IFNG IL2 TNF
48 parasitic protozoa infectious disease 10.2 IFNG IL2 TNF
49 filariasis 10.2 IFNG IL2 TNF
50 keratoconjunctivitis 10.2 IFNG IL2 TNF

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to Smallpox

Symptoms & Phenotypes for Smallpox

UMLS symptoms related to Smallpox:


pruritus, fever, exanthema

MGI Mouse Phenotypes related to Smallpox:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.86 IL2 PRKCQ CSF2 TNF GOLGA3 IFNG
2 hematopoietic system MP:0005397 9.85 PRKCQ CSF2 TNF GOLGA3 GZMA IFNG
3 neoplasm MP:0002006 9.5 PRKCQ CSF2 TNF GZMA IFNG IL12RB2
4 reproductive system MP:0005389 9.23 IL2 PRKCQ SPIRE1 CSF2 TNF GOLGA3

Drugs & Therapeutics for Smallpox

Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
2 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 1
3 gamma-Globulins Phase 4,Phase 2,Phase 1
4 Immunoglobulins Phase 4,Phase 2,Phase 1
5 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 1
6 Antibodies Phase 4,Phase 2,Phase 1
7
Phenol Approved, Experimental Phase 2 108-95-2 996
8
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
9 tannic acid Approved, Nutraceutical Phase 1, Phase 2
10
Mannitol Approved, Investigational Phase 1 69-65-8 6251 453
11 interferons Phase 1
12 Cathartics Phase 1
13 Adjuvants, Immunologic Phase 1
14 Gastrointestinal Agents Phase 1
15 Anti-Bacterial Agents Phase 1
16 Pharmaceutical Solutions Phase 1
17 Anti-Infective Agents Phase 1
18 Poly I-C Phase 1
19 Poly ICLC Phase 1
20 Interferon Inducers Phase 1
21 Protective Agents Phase 1
22 Keyhole-limpet hemocyanin Phase 1
23 Krestin Phase 1
24 Laxatives Phase 1
25 Antibiotics, Antitubercular Phase 1
26 Liver Extracts Phase 1
27 Radiation-Protective Agents Phase 1
28 Carboxymethylcellulose Sodium Phase 1
29 Antiviral Agents Phase 1
30 diuretics Phase 1
31 Natriuretic Agents Phase 1
32 Interferon-gamma

Interventional clinical trials:

(show top 50) (show all 83)

# Name Status NCT ID Phase Drugs
1 Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV) Completed NCT01158157 Phase 4
2 Special Access Program IMVAMUNE® Completed NCT03472014 Phase 4
3 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
4 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3 smallpox vaccine CJ-50300
5 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3 smallpox vaccine CJ-50300
6 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
7 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
8 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3 tecovirimat
9 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
10 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
11 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
12 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Completed NCT02038881 Phase 2
13 A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain) Completed NCT00998543 Phase 2
14 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
15 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
16 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2 MVA Smallpox vaccine;Placebo
17 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
18 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
19 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
20 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
21 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
22 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
23 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
24 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
25 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
26 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2 Placebo (subcutaneous);Placebo (scarification)
27 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
28 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
29 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
30 Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Completed NCT00316589 Phase 2
31 A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis Completed NCT00316602 Phase 2
32 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients Completed NCT00189904 Phase 1, Phase 2
33 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
34 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2 Placebo
35 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
36 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
37 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2 NP-016 Vaccine Immune Globulin (IV-VIG)
38 Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis Completed NCT00723489 Phase 1, Phase 2 YFV-17D Placebo
39 A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites Completed NCT00890760 Phase 1, Phase 2
40 PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate Cancer Completed NCT00005916 Phase 2 rV-PSA;rF-PSA;rV-B7.1
41 Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246 Completed NCT00907803 Phase 2 ST-246 400 mg;ST-246 600 mg;Placebo
42 Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT01266083 Phase 2
43 Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Terminated NCT00053508 Phase 2
44 Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults Completed NCT00079820 Phase 1
45 Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax® Completed NCT00042094 Phase 1
46 Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects Completed NCT00189969 Phase 1
47 Human Immune Responses Smallpox Completed NCT00068198 Phase 1
48 Safety and Immunogenicity of CJ-50300 Completed NCT00336635 Phase 1
49 A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers Completed NCT00002261 Phase 1
50 Safety, Reactogenicity and Immunogenicity of MVA in Hematopoietic Stem Cell Transplant (HSCT) Subjects Completed NCT00565929 Phase 1 Placebo

Search NIH Clinical Center for Smallpox

Cochrane evidence based reviews: smallpox

Genetic Tests for Smallpox

Anatomical Context for Smallpox

The Foundational Model of Anatomy Ontology organs/tissues related to Smallpox:

18
Skin

MalaCards organs/tissues related to Smallpox:

38
Skin, T Cells, Testes, Eye, Myeloid, Prostate, Liver

Publications for Smallpox

Articles related to Smallpox:

(show top 50) (show all 666)
# Title Authors Year
1
Does smallpox vaccination modify HIV disease progression among ART-naive people living with HIV in Africa? ( 29235428 )
2018
2
E3L and F1L Gene Functions Modulate the Protective Capacity of Modified Vaccinia Virus Ankara Immunization in Murine Model of Human Smallpox. ( 29300297 )
2018
3
Challenges and Achievements in Prevention and Treatment of Smallpox. ( 29382130 )
2018
4
How Valid Are Assumptions About Re-emerging Smallpox? A Systematic Review of Parameters Used in Smallpox Mathematical Models. ( 29425329 )
2018
5
40 Years without Smallpox. ( 29340212 )
2017
6
Smallpox (Variola) ( 29262186 )
2017
7
Labmade smallpox is possible, study shows. ( 28706017 )
2017
8
Characterization of Two Historic Smallpox Specimens from a Czech Museum. ( 28749451 )
2017
9
Variola minor in coalfield areas of England and Wales, 1921-34: Geographical determinants of a national smallpox epidemic that spread out of effective control. ( 28351006 )
2017
10
Successful treatment of smallpox scars by using radiofrequency device with single microneedle. ( 28547841 )
2017
11
Viral Evolution: Mummy Virus Challenges Presumed History of Smallpox. ( 28171759 )
2017
12
The Threat of Synthetic Smallpox: European Perspectives. ( 29178813 )
2017
13
Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines. ( 28827144 )
2017
14
Considering the "public" in public health: popular resistance to the Smallpox Eradication Programme in India. ( 28512076 )
2017
15
The Effect of Smallpox and Bacillus Calmette-GuAcrin Vaccination on the Risk of Human Immunodeficiency Virus-1 Infection in Guinea-Bissau and Denmark. ( 28852677 )
2017
16
Comparative Efficacy of Intramuscular and Scarification Routes of Administration of Live Smallpox Vaccine in a Murine Challenge Model. ( 28606813 )
2017
17
Donald Ainslie (D.A.) Henderson, M.D., M.P.H. (1928 - 2016) Smallpox Eradication: Leadership and Legacy. ( 28170040 )
2017
18
Improving the Care and Treatment of Monkeypox Patients in Low-Resource Settings: Applying Evidence from Contemporary Biomedical and Smallpox Biodefense Research. ( 29231870 )
2017
19
George Boole, saucy little Alice and an uneventful smallpox vaccination: one of the greatest stories never told. ( 28235836 )
2017
20
An Early American Smallpox Vaccine Based on Horsepox. ( 29020595 )
2017
21
Comment: Characterization of Two Historic Smallpox Specimens from a Czech Museum. ( 28956829 )
2017
22
Al Rhazes and the Beginning of the End of Smallpox. ( 28492840 )
2017
23
The last major outbreak of smallpox (Yugoslavia, 1972): The importance of historical reminders. ( 28545976 )
2017
24
Relocating Pastorian Medicine: Accommodation and Acclimatization of Pastorian Practices against Smallpox at the Pasteur Institute of Chengdu, China, 1908-1927. ( 28397646 )
2017
25
Duration of neutralizing antibody persisting in Thai individuals after childhood vaccination against smallpox. ( 28577520 )
2017
26
Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations. ( 28046039 )
2017
27
The Peace Gun and the Eradication of Smallpox. ( 28290922 )
2017
28
Short-term clinical safety profile of brincidofovir: A favorable benefit-risk proposition in the treatment of smallpox. ( 28093339 )
2017
29
The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations for Preventing the Reemergence of Smallpox. ( 28836863 )
2017
30
Smallpox vaccination: an early start of modern medicine in America. ( 28634531 )
2017
31
Equination (inoculation of horsepox): An early alternative to vaccination (inoculation of cowpox) and the potential role of horsepox virus in the origin of the smallpox vaccine. ( 29137821 )
2017
32
Treacle and Smallpox: Two Tests for Multicriteria Decision Analysis Models in Health Technology Assessment. ( 28292498 )
2017
33
Defending against smallpox: a focus on vaccines. ( 27049653 )
2016
34
Modelling and Bayesian analysis of the Abakaliki smallpox data. ( 28038869 )
2016
35
A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BNAr) in 56-80-Year-Old Subjects. ( 27327616 )
2016
36
Use of Vaccinia Virus Smallpox Vaccine in Laboratory and Health Care Personnel at Risk for Occupational Exposure to Orthopoxviruses - Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2015. ( 26985679 )
2016
37
Smallpox and Dracunculiasis: The Scientific Value of Infectious Diseases That Have Been Eradicated or Targeted for Eradication. Is Schistosomiasis Next? ( 26741130 )
2016
38
17(th) Century Variola Virus Reveals the Recent History of Smallpox. ( 27939314 )
2016
39
Buccal viral DNA as a trigger for brincidofovir therapy in the mousepox model of smallpox. ( 28039021 )
2016
40
Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972. ( 27999233 )
2016
41
Genome Sequence of Vaccinia virus Strain Lister-Butantan, a Lister Vaccine Variant Used during a Smallpox Eradication Campaign in Brazil. ( 27340056 )
2016
42
Erratum: Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial. ( 26949713 )
2016
43
An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data. ( 27052692 )
2016
44
The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. ( 27513748 )
2016
45
Position on reproductive donors andA smallpox vaccine: a committee opinion. ( 26829211 )
2016
46
Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox. ( 26889021 )
2016
47
Formulation and characterization of ternary inclusion complex containing hydroxypropyl-I^-cyclodextrin and meglumine for solubility enhancement of poorly water-soluble ST-246, an anti-smallpox drug. ( 27697036 )
2016
48
DA Henderson, Smallpox Eradicator. ( 27715298 )
2016
49
A New Document on Smallpox Vaccination. ( 28010829 )
2016
50
Urban inoculation and the decline of smallpox mortality in eighteenth-century cities-a reply to Razzell. ( 26900169 )
2016

Variations for Smallpox

Expression for Smallpox

Search GEO for disease gene expression data for Smallpox.

Pathways for Smallpox

Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 CSF2 IFNG IL12RB2 IL18 IL18R1 IL2
2
Show member pathways
13.36 CSF2 IL12RB2 IL18 IL18R1 IL2 PRKCQ
3
Show member pathways
13.29 CSF2 IFNG IL12RB2 IL18 IL18BP IL18R1
4
Show member pathways
13.26 CSF2 IL12RB2 IL18 IL18R1 IL2 PRKCQ
5
Show member pathways
12.75 IFNG IL18 IL2 PRKCQ TNF
6
Show member pathways
12.56 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
7
Show member pathways
12.54 IFNG IL18 IL18R1 IL2 TNF
8 12.52 GZMA IFNG IL2 PRKCQ TNF
9
Show member pathways
12.46 CSF2 IFNG IL2 PRKCQ TNF
10
Show member pathways
12.45 IFNG IL12RB2 IL18 IL18R1 IL2 PRKCQ
11
Show member pathways
12.36 CSF2 IFNG IL2 PRKCQ TNF
12
Show member pathways
12.33 CSF2 IFNG IL12RB2 IL2
13
Show member pathways
12.1 IFNG IL18 IL2 TNF
14 11.94 IFNG IL2 TNF
15 11.92 CSF2 IFNG IL2 TNF
16 11.89 CSF2 IL18R1 TNF
17 11.84 CSF2 IFNG TNF
18 11.82 IL18 IL2 PRKCQ
19
Show member pathways
11.79 GZMA IFNG IL12RB2 IL18 IL18R1 IL2
20 11.78 CSF2 IFNG IL18
21 11.78 CSF2 IFNG IL18 TNF
22 11.75 CSF2 IFNG IL2
23 11.68 CSF2 IFNG IL2 TNF
24
Show member pathways
11.65 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
25
Show member pathways
11.6 CSF2 IFNG IL2 TNF
26
Show member pathways
11.6 CSF2 IFNG IL2 PRKCQ TNF
27
Show member pathways
11.56 IFNG IL2 PRKCQ TNF
28 11.53 IFNG IL2 TNF
29 11.5 CSF2 IL18 TNF
30 11.5 IFNG IL18 TNF
31 11.49 IFNG IL2 TNF
32 11.48 IFNG IL18 TNF
33 11.46 IFNG IL12RB2 IL2
34 11.32 IFNG IL18 TNF
35 11.25 IFNG IL18 TNF
36 11.21 CSF2 IFNG IL2 TNF
37 11.18 CSF2 IL18 IL2 TNF
38 11.15 IFNG IL18 IL18R1 IL2
39 11.11 IFNG IL12RB2 IL18R1
40 11 GZMA IFNG IL12RB2 IL18 IL2 TNF
41 10.99 IFNG IL18
42
Show member pathways
10.91 CSF2 GZMA IFNG IL2 TNF

GO Terms for Smallpox

Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.91 CSF2 IFNG IL18 IL2 TNF
2 MAPK cascade GO:0000165 9.86 CSF2 IL18 IL2 TNF
3 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.58 CSF2 IL18
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
5 regulation of regulatory T cell differentiation GO:0045589 9.57 IFNG IL2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.56 CSF2 IFNG IL18 IL2
7 positive regulation of podosome assembly GO:0071803 9.55 CSF2 TNF
8 T-helper 1 type immune response GO:0042088 9.54 IL18 IL18BP
9 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 IL18 IL18R1 TNF
10 interferon-gamma production GO:0032609 9.52 IL12RB2 IL18
11 natural killer cell activation GO:0030101 9.5 IL18 IL18R1 IL2
12 immune response GO:0006955 9.5 CSF2 GZMA IFNG IL18 IL18R1 IL2
13 positive regulation of tissue remodeling GO:0034105 9.49 IL18 IL2
14 positive regulation of interleukin-23 production GO:0032747 9.48 CSF2 IFNG
15 interleukin-18-mediated signaling pathway GO:0035655 9.46 IL18 IL18R1
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
17 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 IFNG TNF
18 positive regulation of interleukin-17 production GO:0032740 9.33 IL18 IL2 PRKCQ
19 positive regulation of interferon-gamma production GO:0032729 9.02 IL12RB2 IL18 IL18R1 IL2 TNF

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CSF2 IFNG IL18 IL2 TNF

Sources for Smallpox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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