MCID: SML019
MIFTS: 44

Smallpox malady

Rare diseases, Infectious diseases, Skin diseases categories

Aliases & Classifications for Smallpox

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Aliases & Descriptions for Smallpox:

Name: Smallpox 10 45 47 12 35 2 65
Ordinary Smallpox 10
 
Variola 45


Classifications:



External Ids:

Disease Ontology10 DOID:8736
MeSH36 D012899
ICD9CM29 050.9, 050
NCIt42 C35027
ICD1027 B03

Summaries for Smallpox

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MedlinePlus:35 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards based summary: Smallpox, also known as ordinary smallpox, is related to atopy and tularemia. An important gene associated with Smallpox is IL18R1 (Interleukin 18 Receptor 1), and among its related pathways are Hypertrophy Model and Immune response_IL-12 signaling pathway. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Disease Ontology:10 A viral infectious disease that results in infection located in skin, has material basis in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Related Diseases for Smallpox

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Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1atopy30.4IFNG, IL12RB2, IL18, IL4
2tularemia30.1IFNG, IL18, IL4, TNF
3hepatitis30.0IFNG, IL18, TNF
4leprosy29.6IFNG, IL12RB2, IL2, IL4, TNF
5vaccinia11.0
6variola major10.7
7monkeypox10.7
8milker's nodule10.7
9viral infectious disease10.6
10cowpox10.5
11dermatitis10.4
12variola minor10.4
13atopic dermatitis10.4
14drug rash with eosinophilia and systemic symptoms10.4
15acquired immunodeficiency syndrome10.3
16skin disease10.3
17ohtahara syndrome10.3IFNG, IL18
18chickenpox10.3
19exanthem10.3
20human immunodeficiency virus infectious disease10.3
21myd88 deficiency10.3IFNG, IL4
22severe combined immune deficiency, autosomal recessive t cell-negative, b cell-positive, nk cell-positive, il7r-related10.3IL18R1, IL2
23stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.2IFNG, TNF
24sensorineural hearing loss10.2IFNG, IL4
25autoimmune oophoritis10.2IFNG, TNF
26humero-ulnar synostosis10.2IL18, IL2
27graft-versus-host disease, protection against10.2IFNG, IL2
28alternating exotropia10.2IFNG, IL4
29skin conditions10.2
30yellow fever10.2
31encephalitis10.2
32hepatic tuberculosis10.2IL2, TNF
33best1 retinopathy10.2IFNG, IL18, TNF
34siderosis10.2IL18R1, TNF
35fibrogenesis imperfecta ossium10.2IFNG, IL18, TNF
36leukomelanoderma mental redardation hypotrichosis10.2IL18, IL18R1, TNF
37visceral neuropathy familial10.2IL2, IL4
38primary progressive freezing gait10.2IL4, TNF
39lymphangioma10.2IFNG, IL18, TNF
40acute poststreptococcal glomerulonephritis10.2IFNG, IL18, TNF
41malignant sertoli-leydig cell tumor of ovary10.2IL2, TNF
42thrombocytopenic purpura, autoimmune10.2
43anemia, sideroblastic, pyridoxine-refractory, autosomal recessive10.2
44coronary heart disease 810.2
45pick disease10.2
46thrombocytopenia due to platelet alloimmunization10.2
47spastic diplegia10.2
48folliculitis10.2
49blood platelet disease10.2
50influenza10.2

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Symptoms for Smallpox

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Drugs & Therapeutics for Smallpox

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Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins, IntravenousPhase 4203
2Rho(D) Immune GlobulinPhase 4198
3
Phenolapproved, experimentalPhase 241108-95-2996
Synonyms:
Acide carbolique
Acide phenique
Anbesol
Aseptil Rojo
Benzenol
Benzophenol
Campho-phenique cold sore gel
Campho-phenique gel
Campho-phenique liquid
Carbolic acid
Carbolic acid liquid
Carbolic oil
Carbolicum acidum
Carbolsaeure
Carbolsaure
Care One Sore Throat
Castellani Paint
Castellani Paint 1.5%
Cepastat Cherry
Cepastat Extra Strength
Cepastat lozenges
Chloraseptic Sore Throat
Chloraseptic Sore Throat Cherry
Chloraseptic Sore Throat Citrus
Chloraseptic Sore Throat Menthol
Chloraseptic Warming Sore Throat
Cuticura pain relieving ointment
Dg Health Sore Throat
Equaline Sore Throat
Equate Sore Throat
Fenol
Fenolo
Fenosmolin
Fenosmoline
Good Neighbor Pharmacy Sore Throat
Good Sense Sore Throat
Healthy Accents Sore Throat
Hydroxy-benzene
Hydroxybenzene
IPH
IZAL
Karbolsaeure
Leader Sore Throat
Liquefied phenol
Liquid phenol
 
Liquified phenol
Monohydroxy benzene
Monohydroxybenzene
Monophenol
Oral Relief
Oxybenzene
PHOH
Paoscle
Phenic
Phenic Acid
Phenic acid
Phenic alcohol
Phenol
Phenol alcohol
Phenol homopolymer
Phenol liquid
Phenol molten
Phenol polymer-bound
Phenol solution
Phenol synthetic
Phenolated water
Phenolated water for disinfection
Phenole
Phenosmolin
Phenyl alcohol
Phenyl hydroxide
Phenylic Acid
Phenylic acid
Phenylic alcohol
Rx Act Sore Throat
Smart Sense Sore Throat
Sore Throat
Sore Throat Cherry
Sore Throat Menthol
Sore Throat ReadyInCase
Sore Throat Relief
Sore Throat Relief Cherry
Sore Throat Spray
Sore Throat Spray Cherry
Sore Throat cherry
Sore Throat spray
Sunmark Sore Throat
Synthetic phenol
Tea polyphenol
Throat Relief
Topcare Sore Throat
4
BenzocaineapprovedPhase 1, Phase 215361994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
5
GlycerolexperimentalPhase 217656-81-5753
Synonyms:
1,2,3-Trihydroxypropane
Bulbold
Cristal
E 422
Emery 916
Glyceol Opthalgan
Glycerin
Glycerine
Glyceritol
Glycerol
 
Glycyl alcohol
Glyrol
Glysanin
IFP
Incorporation factor
Mackstat H 66
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Trihydroxypropane
Tryhydroxypropane
6tannic acidNutraceuticalPhase 1, Phase 21536
7Keyhole-limpet hemocyaninPhase 140
8KrestinPhase 1184
9Poly ICLCPhase 164
10Interferon-gamma135

Interventional clinical trials:

(show top 50)    (show all 79)
idNameStatusNCT IDPhase
1Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®)CompletedNCT00928577Phase 4
2Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV)CompletedNCT01158157Phase 4
3Safety Surveillance Study of ACAM2000® Vaccinia VaccineRecruitingNCT00927719Phase 4
4VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIVRecruitingNCT02443623Phase 4
5VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia InfectionEnrolling by invitationNCT01374984Phase 4
6Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy VolunteersCompletedNCT01317238Phase 3
7Safety and Efficacy of CJ Smallpox Vaccine in Healthy VolunteersCompletedNCT01056770Phase 3
8A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve SubjectsCompletedNCT01144637Phase 3
9Safety and Efficacy of CJ-50300 in Healthy VolunteersCompletedNCT00607243Phase 2, Phase 3
10A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000®RecruitingNCT01913353Phase 3
11Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated AdultsCompletedNCT00053482Phase 2
12Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationCompletedNCT00053495Phase 2
13Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young AdultsCompletedNCT00258947Phase 2
14Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox VaccineCompletedNCT00466245Phase 2
15A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain)CompletedNCT00998543Phase 2
16ACAM 3000 MVA at Harvard Medical SchoolCompletedNCT00133575Phase 1, Phase 2
17Dressing Preparations for SmallpoxCompletedNCT00063856Phase 1, Phase 2
18APSV in Vaccinia Naive AdultsCompletedNCT00050518Phase 2
19Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered IntradermallyCompletedNCT00914732Phase 2
20A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated AdultsCompletedNCT00026611Phase 2
21A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy SubjectsCompletedNCT00316524Phase 2
22Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.CompletedNCT00189956Phase 2
23A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced SubjectsCompletedNCT00857493Phase 2
24A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy SubjectsCompletedNCT01668537Phase 2
25MVA Post-Event: Administration Timing and Boost StudyCompletedNCT00437021Phase 1, Phase 2
26Expanded Dryvax Dilution Study in Previously Vaccinated AdultsCompletedNCT00050505Phase 2
27Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®CompletedNCT01827371Phase 2
28A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic DermatitisCompletedNCT00316602Phase 2
29Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOTCompletedNCT00038987Phase 1, Phase 2
30Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected PatientsCompletedNCT00316589Phase 2
31High Dose IMVAMUNE® in Vaccinia-Naive IndividualsCompletedNCT00879762Phase 2
32Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected PatientsCompletedNCT00189904Phase 1, Phase 2
33Dryvax Dilution-Prev Vacc AdultsCompletedNCT00032708Phase 2
34Evaluation and Treatment of Eye Complications of Vaccinia VaccinationCompletedNCT00081835Phase 2
35An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 VaccineesCompletedNCT00686582Phase 2
36Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246CompletedNCT00907803Phase 2
37Immune Response to Yellow Fever Vaccination in Adults With Atopic DermatitisCompletedNCT00723489Phase 1, Phase 2
38A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria ParasitesCompletedNCT00890760Phase 1, Phase 2
39PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate CancerCompletedNCT00005916Phase 2
40Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV InfectionRecruitingNCT02038881Phase 2
41Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated VolunteersActive, not recruitingNCT00103584Phase 1, Phase 2
42Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL)Active, not recruitingNCT01266083Phase 2
43Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox VaccinationTerminatedNCT00053508Phase 2
44Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in AdultsCompletedNCT00079820Phase 1
45Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax®CompletedNCT00042094Phase 1
46A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated VolunteersCompletedNCT00002261Phase 1
47Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive SubjectsCompletedNCT00189969Phase 1
48Human Immune Responses SmallpoxCompletedNCT00068198Phase 1
49Safety and Immunogenicity of CJ-50300CompletedNCT00336635Phase 1
50Combination Study With MVA BN and DryvaxCompletedNCT00082446Phase 1

Search NIH Clinical Center for Smallpox

Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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MalaCards organs/tissues related to Smallpox:

33
Skin, T cells, Testes, B cells, Eye, Breast, Brain

FMA organs/tissues related to Smallpox:

16
Skin

Animal Models for Smallpox or affiliated genes

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MGI Mouse Phenotypes related to Smallpox:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1IFNG, IL2, IL4, MKX, PRKCQ, TNF
2MP:00020067.7GZMA, IFNG, IL12RB2, IL2, PRKCQ, TNF
3MP:00053817.6IFNG, IL12RB2, IL18, IL2, IL4, PRKCQ
4MP:00053976.8GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2
5MP:00053876.5GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2

Publications for Smallpox

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Articles related to Smallpox:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
Lessons from a modern review of the smallpox eradication files. (26432815)
2015
2
Modeling the Effect of Herd Immunity and Contagiousness in Mitigating a Smallpox Outbreak. (25480757)
2014
3
Unintentional transfer of vaccinia virus associated with smallpox vaccines: ACAM2000(Ar) compared with Dryvax(Ar). (23571177)
2013
4
Evaluation of a non-viral vaccine in smallpox-vaccinated individuals and immunized HLA-transgenic mice. (22504409)
2012
5
Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults. (22829644)
2012
6
The discontinuation of routine smallpox vaccination in the United States, 1960-1976: an unlikely affirmation of biomedical hegemony. (21340322)
2011
7
Smallpox and its eradication in the Democratic Republic of Congo: lessons learned. (22188930)
2011
8
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
9
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses. (21235430)
2011
10
Proceedings of a symposium: Smallpox Eradication after 30 Years: Lessons, Legacies and Innovations, August 24-27, 2010, Rio de Janeiro, Brazil. (22860253)
2011
11
Smallpox eradication, laboratory visits, and a touch of tourism: travel notes of a Canadian scientist in Brazil. (21461539)
2010
12
A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge. (20659519)
2010
13
Effectiveness assessment of countermeasures against bioterrorist smallpox attacks in Japan using an individual-based model. (19784718)
2010
14
ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile. (20531961)
2010
15
Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination. (21209900)
2010
16
Killing a killer: what next for smallpox? (20126444)
2010
17
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. (19349521)
2009
18
Possible autoimmune reactions following smallpox vaccination: the biologic false positive test for syphilis. (19022322)
2009
19
Pursuing protection from disease: the making of smallpox prophylactic practice in colonial Punjab. (19329846)
2009
20
Responding to suspected smallpox cases in the Los Angeles County from 2002 to 2006: identifying areas for education. (19041534)
2009
21
Phenotypic and genetic diversity of the traditional Lister smallpox vaccine. (19059294)
2009
22
Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. (18923431)
2009
23
Squamous cell carcinoma in situ arising in a smallpox vaccination scar. (18477155)
2008
24
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. (18226434)
2008
25
Smallpox: dispelling the myths. (19142290)
2008
26
Self-reported adverse health events following smallpox vaccination in a large prospective study of US military service members. (18382134)
2008
27
US Civilian Smallpox Preparedness and Response Program, 2003. (18284355)
2008
28
Follow-up of cardiovascular adverse events after smallpox vaccination among civilians in the United States, 2003. (18284366)
2008
29
Multifaceted contributions: health workers and smallpox eradication in India. (18813588)
2008
30
Public health and bioterrorism: renewed threat of anthrax and smallpox. (17485954)
2007
31
Safety, immunogenicity and protective efficacy in mice of a new cell-cultured Lister smallpox vaccine candidate. (17964011)
2007
32
Transcriptional interactions during smallpox infection and identification of early infection biomarkers. (17992748)
2007
33
Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: the Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3. (18037545)
2007
34
Comparison of military and civilian reporting rates for smallpox vaccine adverse events. (17154344)
2007
35
The immunogenetics of smallpox vaccination. (17570108)
2007
36
Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpox. (16804475)
2006
37
Mass vaccination and surveillance/containment in the eradication of smallpox. (16989262)
2006
38
Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain. (16139395)
2006
39
Five years after 9/11-fearing smallpox, ... and the vaccine against it. (17033745)
2006
40
Genomic sequence and analysis of a vaccinia virus isolate from a patient with a smallpox vaccine-related complication. (17062162)
2006
41
Absence of detectable viremia in plasma and peripheral blood mononuclear cells from smallpox vaccinees: implications for blood safety. (16965588)
2006
42
Smallpox antiviral drug development: satisfying the animal efficacy rule. (16597208)
2006
43
Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients. (16216396)
2006
44
Immunity and immunological memory following smallpox vaccination. (16824139)
2006
45
Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus. (15951823)
2005
46
A population survey of smallpox knowledge, perceptions, and healthcare-seeking behavior surrounding the Iraq invasion--Connecticut 2002-03. (16181047)
2005
47
Stability of diluted smallpox vaccine under simulated clinical conditions. (16005123)
2005
48
Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus). (14604375)
2003
49
Human monkeypox and smallpox viruses: genomic comparison. (11734207)
2001
50
The survival of smallpox virus (variola minor) in natural circumstances. (4299528)
1968

Variations for Smallpox

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Expression for genes affiliated with Smallpox

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Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

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Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL18
29.7IFNG, IL12RB2, IL18R1
39.5IFNG, IL18, TNF
49.5IFNG, IL18, TNF
59.5IFNG, IL18, TNF
69.5IFNG, IL18, TNF
79.4IFNG, IL2, TNF
89.4IFNG, IL2, IL4
99.4IFNG, IL2, IL4
109.4IFNG, IL2, IL4
119.3IFNG, IL18, IL18R1, IL2
12
Show member pathways
9.1IFNG, IL12RB2, IL2, IL4
139.0IL18, IL2, PRKCQ
149.0IFNG, IL2, IL4, TNF
159.0IFNG, IL2, IL4, TNF
16
Show member pathways
8.9IFNG, IL18, IL18R1, IL2, TNF
17
Show member pathways
8.9GZMA, IFNG, IL2, TNF
18
Show member pathways
8.7IFNG, IL18, IL2, IL4, TNF
19
Show member pathways
8.6IFNG, IL2, PRKCQ, TNF
20
Show member pathways
8.6IFNG, IL12RB2, IL18, IL18R1, IL2, TNF
21
Show member pathways
8.1IFNG, IL2, IL4, PRKCQ, TNF
22
Show member pathways
8.1IFNG, IL2, IL4, PRKCQ, TNF
23
B cell receptor signaling pathway (KEGG)
Show member pathways
8.1IFNG, IL2, IL4, PRKCQ, TNF
24
Show member pathways
8.1IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
25
Show member pathways
8.0GZMA, IFNG, IL12RB2, IL18, IL18R1, IL2
26
Show member pathways
7.9GZMA, IL2, IL4, PRKCQ, TNF
27
Show member pathways
7.8IFNG, IL18, IL2, IL4, PRKCQ, TNF
287.6GZMA, IFNG, IL2, IL4, PRKCQ, TNF
29
Show member pathways
7.6IFNG, IL12RB2, IL18, IL18R1, IL2, IL4
30
Show member pathways
7.6IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
31
Show member pathways
7.6IL12RB2, IL18, IL18R1, IL2, IL4, PRKCQ
32
Show member pathways
7.3IFNG, IL12RB2, IL18, IL18R1, IL2, IL4

GO Terms for genes affiliated with Smallpox

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Cellular components related to Smallpox according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0IFNG, IL12RB2, IL4, TNF

Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.5IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.4IFNG, TNF
3positive regulation of tissue remodelingGO:003410510.4IL18, IL2
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IFNG, TNF
5type 2 immune responseGO:004209210.3IL18, IL4
6positive regulation of MHC class II biosynthetic processGO:004534810.3IFNG, IL4
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.2IL2, IL4
8positive regulation of mononuclear cell migrationGO:007167710.2IL4, TNF
9defense response to protozoanGO:004283210.2IFNG, IL4
10negative regulation of growth of symbiont in hostGO:004413010.2IFNG, TNF
11natural killer cell activationGO:003010110.1IL18, IL18R1, IL2
12positive regulation of osteoclast differentiationGO:004567210.1IFNG, TNF
13positive regulation of T cell differentiationGO:004558210.1IL2, IL4
14positive regulation of chemokine biosynthetic processGO:00450809.9IFNG, IL4, TNF
15positive regulation of isotype switching to IgG isotypesGO:00483049.8IFNG, IL2, IL4
16negative regulation of myoblast differentiationGO:00456629.8IL18, MKX, TNF
17positive regulation of activated T cell proliferationGO:00421049.8IL18, IL2, IL4
18cellular response to lipopolysaccharideGO:00712229.7IFNG, IL18, TNF
19positive regulation of interleukin-17 productionGO:00327409.6IL18, IL2, PRKCQ
20positive regulation of interferon-gamma productionGO:00327299.4IL12RB2, IL18, IL18R1, IL2, TNF
21positive regulation of gene expressionGO:00106289.3IFNG, IL18, MKX, TNF
22positive regulation of NF-kappaB import into nucleusGO:00423469.2IL18, IL18R1, PRKCQ, TNF
23positive regulation of T cell proliferationGO:00421028.3IFNG, IL2, IL4, PRKCQ
24immune responseGO:00069558.0GZMA, IFNG, IL18, IL18R1, IL2, IL4

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.7IFNG, IL18, IL2, IL4, TNF

Sources for Smallpox

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet