MCID: SML019
MIFTS: 54

Smallpox malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Smallpox

Aliases & Descriptions for Smallpox:

Name: Smallpox 12 50 52 41 3 42 14 69
Ordinary Smallpox 12
Variola 50

Classifications:



External Ids:

Disease Ontology 12 DOID:8736
ICD10 33 B03
ICD9CM 35 050 050.9
MeSH 42 D012899
NCIt 47 C35027
UMLS 69 C0037354

Summaries for Smallpox

MedlinePlus : 41 smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards based summary : Smallpox, also known as ordinary smallpox, is related to hepatitis and tularemia, and has symptoms including exanthema, fever and pruritus. An important gene associated with Smallpox is MKX (Mohawk Homeobox), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Vaccines and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are digestive/alimentary and neoplasm

Disease Ontology : 12 A viral infectious disease that results_in infection located in skin, has material basis in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

CDC : 3 Thousands of years ago, variola virus (smallpox virus) emerged and began causing illness and deaths in human populations, with smallpox outbreaks occurring from time to time. Thanks to the success of vaccination, the last natural outbreak of smallpox in the United States occurred in 1949. In 1980, the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since. 

Wikipedia : 71 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Related Diseases for Smallpox

Diseases related to Smallpox via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 hepatitis 29.5 IFNG IL2 TNF
2 tularemia 29.5 IFNG IL2 IL4 TNF
3 tuberculosis 29.3 IL2 IL4 TNF
4 variola major 11.7
5 cowpox 11.4
6 variola minor 11.4
7 vaccinia 11.2
8 monkeypox 11.2
9 viral infectious disease 10.7
10 tau syndrome 10.3 IL18 TNF
11 myoglobinuria recurrent 10.3 IFNG IL4
12 glucose intolerance 10.2 IFNG IL18 TNF
13 leydig cell hypoplasia 10.2 IL18 IL18R1 TNF
14 steatitis 10.2 IL2 TNF
15 asymptomatic neurosyphilis 10.2 IFNG IL4
16 benign eccrine breast spiradenoma 10.2 IFNG IL18 TNF
17 tubular renal disease-cardiomyopathy syndrome 10.2 IL4 TNF
18 geniculate ganglionitis 10.2 IFNG IL18 TNF
19 stocco dos santos syndrome 10.2 IFNG TNF
20 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG IL2 TNF
21 plantar wart 10.2 IFNG IL2 TNF
22 amyotrophic lateral sclerosis type 14 10.2 IFNG IL2 TNF
23 parametritis 10.2 IFNG IL2 TNF
24 cyclosporiasis 10.2 IFNG IL2 TNF
25 venezuelan hemorrhagic fever 10.2 IFNG IL2 TNF
26 strawberry gallbladder 10.2 IFNG IL2 TNF
27 urethral intrinsic sphincter deficiency 10.2 IFNG IL4 TNF
28 hypotrichosis 4 10.2 IFNG IL4 TNF
29 osteodysplasty precocious of danks mayne and kozlowski 10.2 IFNG IL4 TNF
30 neurotic disorder 10.2 IFNG IL4 TNF
31 mansonelliasis 10.2 IFNG IL2 TNF
32 ectodermal dysplasia bartalos type 10.2 IFNG IL4 TNF
33 oral cavity cancer 10.1 IFNG IL4 TNF
34 periodontosis 10.1 IFNG IL2 TNF
35 anterior foramen magnum meningioma 10.1 IFNG IL2 TNF
36 motor peripheral neuropathy 10.1 IFNG IL4 TNF
37 lagophthalmos 10.1 IL4 TNF
38 status epilepticus 10.1 IFNG IL4 TNF
39 balkan nephropathy 10.1 IFNG IL4 TNF
40 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.1 IFNG IL2 IL4
41 deafness, autosomal recessive 67 10.1 IFNG IL12RB2 IL18 TNF
42 parasitic protozoa infectious disease 10.1 IFNG IL4 TNF
43 hallucinogen dependence 10.1 IFNG IL4 TNF
44 anus leiomyosarcoma 10.1 IFNG IL2 TNF
45 keratomalacia 10.1 IFNG IL4 TNF
46 central nervous system origin vertigo 10.1 IFNG IL2 IL4
47 sarcoma 10.1 IL2 IL4
48 pulmonary tuberculosis 10.1 IFNG IL4 TNF
49 retinal ischemia 10.1 IFNG IL18 IL2 TNF
50 mast-cell leukemia 10.1 IFNG IL4 TNF

Graphical network of the top 20 diseases related to Smallpox:



Diseases related to Smallpox

Symptoms & Phenotypes for Smallpox

UMLS symptoms related to Smallpox:


exanthema, fever, pruritus

MGI Mouse Phenotypes related to Smallpox:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 IFNG IL12RB2 IL18 IL2 IL4 PRKCQ
2 neoplasm MP:0002006 9.43 PRKCQ TNF GZMA IFNG IL12RB2 IL2
3 reproductive system MP:0005389 9.23 GOLGA3 IFNG IL2 IL4 PRKCQ SPIRE1

Drugs & Therapeutics for Smallpox

Drugs for Smallpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
2 Immunoglobulins Phase 4,Phase 2,Phase 1
3 gamma-Globulins Phase 4,Phase 2,Phase 1
4 Immunoglobulins, Intravenous Phase 4,Phase 2,Phase 1
5 Rho(D) Immune Globulin Phase 4,Phase 2,Phase 1
6 Antibodies Phase 4,Phase 2,Phase 1
7
Glycerol Approved, Experimental Phase 2 56-81-5 753
8
Phenol Approved, Experimental Phase 2 108-95-2 996
9
Benzocaine Approved Phase 1, Phase 2 1994-09-7, 94-09-7 2337
10 tannic acid Approved, Nutraceutical Phase 1, Phase 2
11
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
12 interferons Phase 1
13 Adjuvants, Immunologic Phase 1
14 Gastrointestinal Agents Phase 1
15 Pharmaceutical Solutions Phase 1
16 Anti-Bacterial Agents Phase 1
17 Poly I-C Phase 1
18 Poly ICLC Phase 1
19 Anti-Infective Agents Phase 1
20 Protective Agents Phase 1
21 Interferon Inducers Phase 1
22 Keyhole-limpet hemocyanin Phase 1
23 Krestin Phase 1
24 Laxatives Phase 1
25 Liver Extracts Phase 1
26 Radiation-Protective Agents Phase 1
27 Antibiotics, Antitubercular Phase 1
28 Antiviral Agents Phase 1
29 Cathartics Phase 1
30 Carboxymethylcellulose Sodium Phase 1
31 diuretics Phase 1
32 Natriuretic Agents Phase 1
33 Interferon-gamma

Interventional clinical trials:

(show top 50) (show all 82)
id Name Status NCT ID Phase
1 Safety Surveillance Cohort Study of Vaccinia Vaccine (ACAM2000®) Completed NCT00928577 Phase 4
2 Vaccinia Vaccine (ACAM2000) for the Production of Vaccinia Immune Globulin Intravenous(VIGIV) Completed NCT01158157 Phase 4
3 VA-008 ACAM2000® Vaccination of Plasma Donors for the Production of VIGIV Recruiting NCT02443623 Phase 4
4 VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection Enrolling by invitation NCT01374984 Phase 4
5 Safety and Efficacy of CJ Smallpox Vaccine in Previously Vaccinated Healthy Volunteers Completed NCT01317238 Phase 3
6 Safety and Efficacy of CJ Smallpox Vaccine in Healthy Volunteers Completed NCT01056770 Phase 3
7 A Trial to Evaluate Immunogenicity and Safety of Three Consecutive Production Lots of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in Healthy, Vaccinia-naïve Subjects Completed NCT01144637 Phase 3
8 Safety and Efficacy of CJ-50300 in Healthy Volunteers Completed NCT00607243 Phase 2, Phase 3
9 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of the Anti-Orthopoxvirus Compound Tecovirimat Completed NCT02474589 Phase 3
10 IMVAMUNE® Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo Recruiting NCT02977715 Phase 3
11 A Non-inferiority Trial to Compare MVA-BN® Smallpox Vaccine to ACAM2000® Active, not recruiting NCT01913353 Phase 3
12 Safety and Immunogenicity Study of LC16m8, a Modified Smallpox Vaccine, in Healthy, Previously Unvaccinated Volunteers Unknown status NCT00103584 Phase 1, Phase 2
13 Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Completed NCT00053495 Phase 2
14 Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults Completed NCT00053482 Phase 2
15 A Long-Term Study of Healthy Adults Vaccinated With One Dose of Smallpox Vaccine (LISTER Strain) Completed NCT00998543 Phase 2
16 Dressing Preparations for Smallpox Completed NCT00063856 Phase 1, Phase 2
17 Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine Completed NCT00466245 Phase 2
18 Evaluation of Take and Safety of a Smallpox Vaccine in Healthy Young Adults Completed NCT00258947 Phase 2
19 APSV in Vaccinia Naive Adults Completed NCT00050518 Phase 2
20 A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated Adults Completed NCT00026611 Phase 2
21 Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine. Completed NCT00189956 Phase 2
22 A Study to Evaluate Safety and Immunogenicity of One and Two Doses of IMVAMUNE® Smallpox Vaccine in 56-80 Year Old Vaccinia-experienced Subjects Completed NCT00857493 Phase 2
23 A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects Completed NCT01668537 Phase 2
24 A Randomized, Double-blind, Placebo-controlled Study on Immunogenicity and Safety of MVA-BN (IMVAMUNE™) Smallpox Vaccine in Healthy Subjects Completed NCT00316524 Phase 2
25 Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE® Completed NCT01827371 Phase 2
26 MVA Post-Event: Administration Timing and Boost Study Completed NCT00437021 Phase 1, Phase 2
27 Expanded Dryvax Dilution Study in Previously Vaccinated Adults Completed NCT00050505 Phase 2
28 Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally Completed NCT00914732 Phase 2
29 ACAM 3000 MVA at Harvard Medical School Completed NCT00133575 Phase 1, Phase 2
30 Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients Completed NCT00316589 Phase 2
31 A Phase II Study on Immunogenicity and Safety of MVA-BN® (IMVAMUNE™) Smallpox Vaccine in Subjects With Atopic Dermatitis Completed NCT00316602 Phase 2
32 Safety, Tolerability and Immune Response of IMVAMUNE (MVA-BN)Smallpox Vaccine in HIV Infected Patients Completed NCT00189904 Phase 1, Phase 2
33 Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOT Completed NCT00038987 Phase 1, Phase 2
34 High Dose IMVAMUNE® in Vaccinia-Naive Individuals Completed NCT00879762 Phase 2
35 Dryvax Dilution-Prev Vacc Adults Completed NCT00032708 Phase 2
36 An Open-Label Phase II Study to Evaluate Immunogenicity and Safety of a Single IMVAMUNE Booster Vaccination Two Years After the Last IMVAMUNE Vaccination in Former POX-MVA-005 Vaccinees Completed NCT00686582 Phase 2
37 Evaluation and Treatment of Eye Complications of Vaccinia Vaccination Completed NCT00081835 Phase 2
38 Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis Completed NCT00723489 Phase 1, Phase 2
39 A Study to Assess the Effectiveness of a New Malaria Vaccine Candidate by Infecting Vaccinated Volunteers With Malaria Parasites Completed NCT00890760 Phase 1, Phase 2
40 PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate Cancer Completed NCT00005916 Phase 2
41 Safety, Tolerability, Pharmacokinetics (PK) of the Anti-Orthopox Drug, ST-246 Completed NCT00907803 Phase 2
42 Randomized, Open-label Phase II Trial to Assess the Safety and Immunogenicity of MVA-BN Smallpox Vaccine in Immunocompromised Subjects With HIV Infection Active, not recruiting NCT02038881 Phase 2
43 Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT01266083 Phase 2
44 Dose Safety, Tolerability, and Immunogenicity of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination Terminated NCT00053508 Phase 2
45 Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults Completed NCT00079820 Phase 1
46 Study of Reactogenicity, Safety, Immunogenicity, and Pock Lesion Formation of a Cell-Cultured Smallpox Vaccine Compared to Dryvax® Completed NCT00042094 Phase 1
47 Take Rate, Immunogenicity and Safety of Elstree-BN Smallpox Vaccine in Healthy Vaccinia-Naive Subjects Completed NCT00189969 Phase 1
48 Human Immune Responses Smallpox Completed NCT00068198 Phase 1
49 Safety and Immunogenicity of CJ-50300 Completed NCT00336635 Phase 1
50 A Comparative Phase I Clinical Study of HIVAC-1e and Smallpox (Vaccinia) Vaccines in Previously (Vaccinia) Vaccinated and Unvaccinated Volunteers Completed NCT00002261 Phase 1

Search NIH Clinical Center for Smallpox

Cochrane evidence based reviews: smallpox

Genetic Tests for Smallpox

Anatomical Context for Smallpox

MalaCards organs/tissues related to Smallpox:

39
Skin, T Cells, Testes, Eye, B Cells, Breast, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Smallpox:

18
Skin

Publications for Smallpox

Articles related to Smallpox:

(show top 50) (show all 634)
id Title Authors Year
1
Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations. ( 28046039 )
2017
2
Use of Vaccinia Virus Smallpox Vaccine in Laboratory and Health Care Personnel at Risk for Occupational Exposure to Orthopoxviruses - Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2015. ( 26985679 )
2016
3
Long-term safety of replication-defective smallpox vaccine (MVA-BN) in atopic eczema and allergic rhinitis. ( 27357167 )
2016
4
A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox. ( 28003603 )
2016
5
Smallpox and Dracunculiasis: The Scientific Value of Infectious Diseases That Have Been Eradicated or Targeted for Eradication. Is Schistosomiasis Next? ( 26741130 )
2016
6
17(th) Century Variola Virus Reveals the Recent History of Smallpox. ( 27939314 )
2016
7
Adventures of a Female Medical Detective: In Pursuit of Smallpox and AIDS. ( 27402821 )
2016
8
Ectromelia Virus Disease Characterization in the BALB/c Mouse: A Surrogate Model for Assessment of Smallpox Medical Countermeasures. ( 27455306 )
2016
9
Bob H. Reinhardt: The End of A Global Pox. America and the Eradication of Smallpox in the Cold War Era : The University of North Carolina Press, Chapel Hill, 2015, 268 pp., Hard cover, Illustrated, Figure, Maps, Table, Notes, Bibliography, Index., $39.95. ( 28040839 )
2016
10
Formulation and characterization of ternary inclusion complex containing hydroxypropyl-I^-cyclodextrin and meglumine for solubility enhancement of poorly water-soluble ST-246, an anti-smallpox drug. ( 27697036 )
2016
11
Estimating the Size of the U.S. Population at Risk of Severe Adverse Events from Replicating Smallpox Vaccine. ( 27739111 )
2016
12
Estimated prevalence of smallpox vaccine contraindications in Israeli adolescents. ( 27206387 )
2016
13
Smallpox in the post eradication era. ( 27209648 )
2016
14
Urban inoculation and the decline of smallpox mortality in eighteenth-century cities-a reply to Razzell. ( 26900169 )
2016
15
Defending against smallpox: a focus on vaccines. ( 27049653 )
2016
16
Modelling and Bayesian analysis of the Abakaliki smallpox data. ( 28038869 )
2016
17
Povidone Iodine Ointment Application to the Vaccination Site Does Not Alter Immunoglobulin G Antibody Response to Smallpox Vaccine. ( 27214505 )
2016
18
DA Henderson, Smallpox Eradicator. ( 27715298 )
2016
19
Vaccinations against smallpox and tuberculosis are associated with better long-term survival: a Danish case-cohort study 1971-2010. ( 27380797 )
2016
20
History of Smallpox and Its Spread in Human Populations. ( 27726788 )
2016
21
Buccal viral DNA as a trigger for brincidofovir therapy in the mousepox model of smallpox. ( 28039021 )
2016
22
Erratum: Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial. ( 26949713 )
2016
23
Smallpox as an actual biothreat: lessons learned from its outbreak in ex-Yugoslavia in 1972. ( 27999233 )
2016
24
New effective chemically synthesized anti-smallpox compound NIOCH-14. ( 26861777 )
2016
25
Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox. ( 26889021 )
2016
26
Position on reproductive donors andA smallpox vaccine: a committee opinion. ( 26829211 )
2016
27
An interaction quantitative trait loci tool implicates epistatic functional variants in an apoptosis pathway in smallpox vaccine eQTL data. ( 27052692 )
2016
28
A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BNAr) in 56-80-Year-Old Subjects. ( 27327616 )
2016
29
A New Document on Smallpox Vaccination. ( 28010829 )
2016
30
The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine. ( 27513748 )
2016
31
Genome Sequence of Vaccinia virus Strain Lister-Butantan, a Lister Vaccine Variant Used during a Smallpox Eradication Campaign in Brazil. ( 27340056 )
2016
32
Impaired innate, humoral, and cellular immunity despite a take in smallpox vaccine recipients. ( 27177944 )
2016
33
Repeated high-dose (5 A9 10(8)TCID50) toxicity study, of a third generation smallpox vaccine (IMVAMUNE), in New Zealand white rabbits. ( 26836234 )
2016
34
The prevention and eradication of smallpox: a commentary on Sloane (1755) 'An account of inoculation'. ( 25750241 )
2015
35
Smallpox in the Medici family, Florence, 1519-1737: a historical cohort study. ( 25677626 )
2015
36
Smallpox, Anthrax, and the Historiography of Cutaneous Diseases. ( 26650656 )
2015
37
The efficacy and pharmacokinetics of brincidofovir for the treatment of lethal rabbitpox virus infection: A model of smallpox disease. ( 25746331 )
2015
38
Immunomodulator-based enhancement of anti smallpox immune responses. ( 25875833 )
2015
39
Smallpox Vaccination of Laboratory Workers at US Variola Testing Sites. ( 26196153 )
2015
40
Lessons from a modern review of the smallpox eradication files. ( 26432815 )
2015
41
Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial. ( 26380340 )
2015
42
Preparedness for a smallpox pandemic in Japan: public health perspectives. ( 26060873 )
2015
43
Extent of Systemic Spread Determines CD8+ T Cell Immunodominance for Laboratory Strains, Smallpox Vaccines, and Zoonotic Isolates of Vaccinia Virus. ( 26195812 )
2015
44
Cowpox Helped Against Smallpox; Will the Goat Lentivirus (Caprine Arthritis Encephalitis Virus) Help Against HIV-1? ( 25844817 )
2015
45
Modernizing stockpiles of medical countermeasures against smallpox: Benefits, risks, and knowledge gaps. ( 26312493 )
2015
46
Control, containment and health education in the smallpox-vaccination campaigns in Mexico in the 1940s. ( 26038851 )
2015
47
Sex difference in immune response to vaccination: A participant-level meta-analysis of randomized trials of IMVAMUNE(Ar) smallpox vaccine. ( 26319063 )
2015
48
George Washington and Smallpox: A Revolutionary Hero and Public Health Activist. ( 25739090 )
2015
49
Clinical guidance for smallpox vaccine use in a postevent vaccination program. ( 25695372 )
2015
50
Analysis of pregnancy and infant health outcomes among women in the National Smallpox Vaccine in Pregnancy Registry who received Anthrax Vaccine Adsorbed. ( 26049005 )
2015

Variations for Smallpox

Expression for Smallpox

Search GEO for disease gene expression data for Smallpox.

Pathways for Smallpox

Pathways related to Smallpox according to GeneCards Suite gene sharing:

(show all 45)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 IFNG IL12RB2 IL18 IL18R1 IL2 IL4
2
Show member pathways
13.51 IFNG IL12RB2 IL18 IL18R1 IL2 IL4
3
Show member pathways
13.38 IL12RB2 IL18 IL18R1 IL2 IL4 PRKCQ
4
Show member pathways
13.33 IFNG IL12RB2 IL18 IL18R1 IL2 IL4
5
Show member pathways
13.26 IL12RB2 IL18 IL18R1 IL2 IL4 PRKCQ
6
Show member pathways
12.76 GZMA IL2 IL4 PRKCQ TNF
7
Show member pathways
12.74 IFNG IL18 IL2 IL4 PRKCQ TNF
8
Show member pathways
12.55 IFNG IL18 IL18R1 IL2 TNF
9 12.5 GZMA IFNG IL2 IL4 PRKCQ TNF
10
Show member pathways
12.48 IFNG IL2 IL4 PRKCQ TNF
11
Show member pathways
12.48 IFNG IL12RB2 IL18 IL18R1 IL2 IL4
12
Show member pathways
12.37 IFNG IL2 IL4 PRKCQ TNF
13
Show member pathways
12.3 IFNG IL2 IL4 TNF
14
Show member pathways
12.3 IFNG IL12RB2 IL18 IL18R1 IL2 IL4
15
Show member pathways
12.19 IFNG IL12RB2 IL2 IL4
16
Show member pathways
12.1 IFNG IL18 IL2 IL4 TNF
17 11.97 IFNG IL2 IL4 TNF
18 11.95 IFNG IL2 IL4 TNF
19 11.93 IL18 IL4 TNF
20 11.83 IL18 IL2 PRKCQ
21 11.82 IFNG IL18 TNF
22 11.77 IFNG IL2 IL4
23
Show member pathways
11.76 IFNG IL12RB2 IL18 IL18R1 IL2 TNF
24 11.73 IFNG IL2 TNF
25 11.66 IFNG IL12RB2 IL2
26
Show member pathways
11.65 IFNG IL2 IL4 PRKCQ TNF
27
Show member pathways
11.63 IFNG IL2 TNF
28
Show member pathways
11.62 IFNG IL2 PRKCQ TNF
29
Show member pathways
11.55 GZMA IFNG IL12RB2 IL18 IL18R1 IL2
30 11.53 IFNG IL2 TNF
31 11.5 IL18 IL4 TNF
32 11.5 IFNG IL18 TNF
33 11.49 IFNG IL2 TNF
34 11.48 IFNG IL18 TNF
35 11.48 IFNG IL12RB2 IL2 IL4
36
Show member pathways
11.38 GZMA IFNG IL2 TNF
37 11.33 IFNG IL18 TNF
38 11.29 IFNG IL2 IL4
39 11.26 IFNG IL18 IL4 TNF
40
Show member pathways
11.21 IFNG IL12RB2 IL18R1
41 11.21 IFNG IL2 IL4 TNF
42 11.18 IL18 IL2 IL4 TNF
43 11.15 IFNG IL18 IL18R1 IL2
44 11.14 IFNG IL2 IL4
45 11.07 GZMA IFNG IL12RB2 IL18 IL2 IL4

GO Terms for Smallpox

Cellular components related to Smallpox according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 IFNG IL12RB2 IL4 TNF

Biological processes related to Smallpox according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.86 IFNG IL2 IL4 TNF
2 positive regulation of T cell proliferation GO:0042102 9.71 IFNG IL2 IL4 PRKCQ
3 positive regulation of activated T cell proliferation GO:0042104 9.67 IL18 IL2 IL4
4 natural killer cell activation GO:0030101 9.63 IL18 IL18R1 IL2
5 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.61 IL2 IL4
6 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 IL18 IL18R1 TNF
7 negative regulation of growth of symbiont in host GO:0044130 9.6 IFNG TNF
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IFNG TNF
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IFNG IL4
10 type 2 immune response GO:0042092 9.58 IL18 IL4
11 positive regulation of tissue remodeling GO:0034105 9.57 IL18 IL2
12 interleukin-18-mediated signaling pathway GO:0035655 9.55 IL18 IL18R1
13 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 IL2 IL4
14 positive regulation of interleukin-17 production GO:0032740 9.54 IL18 IL2 PRKCQ
15 positive regulation of mononuclear cell migration GO:0071677 9.52 IL4 TNF
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IFNG TNF
17 positive regulation of chemokine biosynthetic process GO:0045080 9.5 IFNG IL4 TNF
18 immune response GO:0006955 9.5 GZMA IFNG IL18 IL18R1 IL2 IL4
19 positive regulation of vitamin D biosynthetic process GO:0060557 9.48 IFNG TNF
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IFNG IL18 IL2 IL4
21 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IFNG IL2 IL4
22 positive regulation of interferon-gamma production GO:0032729 9.02 IL12RB2 IL18 IL18R1 IL2 TNF

Molecular functions related to Smallpox according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL18 IL2 IL4 TNF

Sources for Smallpox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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