MCID: SML019
MIFTS: 43

Smallpox malady

Infectious diseases category

Summaries for Smallpox

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Smallpox is a disease caused by the variola major virus. some experts say that over the centuries it has killed more people than all other infectious diseases combined. worldwide immunization stopped the spread of smallpox three decades ago. the last case was reported in 1977. two research labs still keep small amounts of the virus. experts fear bioterrorists could use the virus to spread disease. smallpox spreads very easily from person to person. symptoms are flu-like. they include high fever fatigue headache backache a rash with flat red sores there is no treatment. fluids and medicines for pain or fever can help control symptoms. most people recover, but some can die. those who do recover may have severe scars. the u.s. stopped routine smallpox vaccinations in 1972. military and other high-risk groups continue to get the vaccine. the u.s. has increased its supply of the vaccine in recent years. the vaccine makes some people sick, so doctors save it for those at highest risk of disease. nih: national institute of allergy and infectious diseases

MalaCards: Smallpox, also known as ordinary smallpox, is related to vaccinia and hepatitis. An important gene associated with Smallpox is HLA-A (major histocompatibility complex, class I, A). The compound endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells.

Disease Ontology:8 A viral infectious disease that results in infection located in skin, has material basis in variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. the infection results in formation of lesions, first on the face, hands and forearms and later on the trunk.

Wikipedia:63 Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola... more...

Aliases & Classifications for Smallpox

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

smallpox 8 42 10 44 33 60
ordinary smallpox 8
variola 42


External Ids:

Disease Ontology8 DOID:8736
ICD9CM27 050.9, 050
MeSH34 D012899
NCIt39 C35027
ICD1025 B03

Related Diseases for Smallpox

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Smallpox:



Diseases related to smallpox

Clinical Features for Smallpox

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Drugs & Therapeutics for Smallpox

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Smallpox

Drug clinical trials:

Search ClinicalTrials for Smallpox

Search NIH Clinical Center for Smallpox

Search CenterWatch for Smallpox

Genetic Tests for Smallpox

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Anatomical Context for Smallpox

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Smallpox:

32
Skin, T cells, Testes, Brain, Eye, Breast, B cells

FMA organs/tissues related to Smallpox:

14
Skin

Animal Models for Smallpox or affiliated genes

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Publications for Smallpox

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Sources:
50PubMed
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Articles related to Smallpox:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
Population-level differences in disease transmission: a Bayesian analysis of multiple smallpox epidemics. (24021521)
2013
2
Preventing the return of smallpox: molecular modeling studies on thymidylate kinase from Variola virus. (23998201)
2013
3
Comparative pathology of smallpox and monkeypox in man and macaques. (22884034)
2013
4
Abigail Adams, smallpox, and the spirit of 1776. (24048429)
2013
5
Lessons from the eradication of smallpox: an interview with D. A. Henderson. (23798700)
2013
6
Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults. (22829644)
2012
7
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses. (21235430)
2011
8
Alternative immunological markers to document successful multiple smallpox revaccinations. (21427392)
2011
9
Smallpox vaccines: targets of protective immunity. (21198662)
2011
10
Smallpox and the epidemiological heritage of modern Japan: towards a total history. (21792253)
2011
11
Animal science. Rinderpest, deadly for cattle, joins smallpox as a vanquished disease. (20966223)
2010
12
The eradication of smallpox, a success story for modern medicine and public health: what lessons for the future? (20539058)
2010
13
Circulating smallpox knowledge: Guatemalan doctors, Maya Indians and designing Spain's smallpox vaccination expedition, 1780-1803. (21553626)
2010
14
Expansion, reexpansion, and recall-like expansion of Vgamma2Vdelta2 T cells in smallpox vaccination and monkeypox virus infection. (19740988)
2009
15
Safeguarding slaves: smallpox, vaccination, and governmental health policies among the enslaved population in the Danish West Indies, 1803-1848. (19329843)
2009
16
Progressive vaccinia in a military smallpox vaccinee - United States, 2009. (19478722)
2009
17
Controversial role of smallpox on historical positive selection at the CCR5 chemokine gene (CCR5-Delta 32). (19759499)
2009
18
Detection of human orthopoxvirus infections and differentiation of smallpox virus with real-time PCR. (19031452)
2009
19
Smallpox and cowpox under the Southern Cross: the smallpox epidemic of 1789 and the advent of vaccination in colonial Australia. (19329841)
2009
20
Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity. (19667083)
2009
21
Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment. (18768877)
2008
22
Introduction: vaccination against smallpox in the posteradication era. (18284354)
2008
23
Comparison of military and civilian reporting rates for smallpox vaccine adverse events. (17154344)
2007
24
The design and development of drugs acting against the smallpox virus. (23496133)
2007
25
The persistence of humoral and cellular immunities more than three decades after smallpox vaccination. (17184294)
2007
26
Rabbitpox virus and vaccinia virus infection of rabbits as a model for human smallpox. (17686856)
2007
27
Public health, culture, and colonial medicine: smallpox and variolation in Palestine during the British Mandate. (17518312)
2007
28
Smallpox vaccination: comparison of self-reported and electronic vaccine records in the millennium cohort study. (17700077)
2007
29
Clinical and immunological responses to undiluted and diluted smallpox vaccine with vaccinia virus of Lister strain. (16139395)
2006
30
Five years after 9/11-fearing smallpox, ... and the vaccine against it. (17033745)
2006
31
Immunity and immunological memory following smallpox vaccination. (16824139)
2006
32
The history of smallpox. (16714195)
2006
33
Smallpox Vaccine Injury Compensation Program: administrative implementation. Adoption of interim final rule as final rule with amendments. (16749218)
2006
34
Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults. (17014939)
2006
35
Smallpox and vaccination in Cuba. 1911. (16550764)
2006
36
Genome sequence diversity and clues to the evolution of variola (smallpox) virus. (16873609)
2006
37
Reaction after smallpox vaccination. (16848388)
2006
38
Validity of self-assessment of skin reaction after smallpox vaccination. (16416697)
2006
39
Estimation of the duration of vaccine-induced residual protection against severe and fatal smallpox based on secondary vaccination failure. (17033746)
2006
40
The earliest notes on the reproduction number in relation to herd immunity: Theophil Lotz and smallpox vaccination. (16875892)
2006
41
Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge. (16430997)
2006
42
Dark Winter and the spring of 1972: deflecting the social lessons of smallpox. (16809125)
2006
43
Australian public and smallpox. (16318729)
2005
44
Countermeasures to the bioterrorist threat of smallpox. (16375715)
2005
45
Prediction of smallpox outbreak and evaluation of control-measure policy in Japan, using a mathematical model. (15856374)
2005
46
Clinical responses to smallpox vaccine in vaccinia-naive and previously vaccinated populations: undiluted and diluted Lancy-Vaxina vaccine in a single-blind, randomized, prospective trial. (16107961)
2005
47
Smallpox. (16168312)
2005
48
Pulmonary manifestations of other agents: brucella, Q fever, tularemia and smallpox. (15062230)
2004
49
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox). (12467606)
2003
50
Distinguishing smallpox from chickenpox. (11883056)
2002

Genetic Variations for Smallpox

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Expression for genes affiliated with Smallpox

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Smallpox

Search GEO for disease gene expression data for Smallpox.

Pathways for genes affiliated with Smallpox

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Compounds for genes affiliated with Smallpox

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44Novoseek
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Compounds related to Smallpox according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1endotoxin4410.6IL18BP, CR1, CCL20

GO Terms for genes affiliated with Smallpox

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Products for genes affiliated with Smallpox

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Smallpox

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet