MCID: SMK004
MIFTS: 34

Smoking As a Quantitative Trait Locus 3

Categories: Genetic diseases, Cancer diseases, Respiratory diseases

Aliases & Classifications for Smoking As a Quantitative Trait Locus 3

MalaCards integrated aliases for Smoking As a Quantitative Trait Locus 3:

Name: Smoking As a Quantitative Trait Locus 3 53 28
Lung Cancer Susceptibility 2 53 13 69
Nicotine Dependence 53 69
Nicotine Dependence, Susceptibility to 53
Sqtl3 53

Classifications:



External Ids:

OMIM 53 612052
UMLS 69 C2677571

Summaries for Smoking As a Quantitative Trait Locus 3

MalaCards based summary : Smoking As a Quantitative Trait Locus 3, also known as lung cancer susceptibility 2, is related to tobacco addiction and substance dependence. An important gene associated with Smoking As a Quantitative Trait Locus 3 is CHRNA5 (Cholinergic Receptor Nicotinic Alpha 5 Subunit), and among its related pathways/superpathways are Transmission across Chemical Synapses and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. Affiliated tissues include lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 612052

Related Diseases for Smoking As a Quantitative Trait Locus 3

Diseases in the Smoking As a Quantitative Trait Locus 3 family:

Smoking As a Quantitative Trait Locus 1 Smoking As a Quantitative Trait Locus 2

Diseases related to Smoking As a Quantitative Trait Locus 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 tobacco addiction 32.0 CHRNA3 CHRNA5
2 substance dependence 28.9 CHRNA3 CHRNA5
3 cocaine dependence 28.8 CHRNA3 CHRNA5
4 schizophrenia 10.2
5 anxiety 10.2
6 lung cancer 10.1
7 alcohol dependence 10.0
8 aging 10.0
9 major depressive disorder 9.9
10 episodic pain syndrome, familial, 1 9.9
11 disease of mental health 9.9
12 alcohol use disorder 9.9
13 attention deficit-hyperactivity disorder 9.8
14 pathological gambling 9.8
15 pancreatic cancer 9.8
16 asthma 9.8
17 bipolar disorder 9.8
18 mood disorder 9.8
19 pancreatitis 9.8
20 neuronitis 9.8
21 autosomal dominant nocturnal frontal lobe epilepsy 9.6 CHRNA3 CHRNA5
22 arteries, anomalies of 9.6
23 bladder cancer 9.6
24 multiple sclerosis 9.6
25 buerger disease 9.6
26 alzheimer disease 11 9.6
27 multiple mitochondrial dysfunctions syndrome 5 9.6
28 peripheral vascular disease 9.6
29 peripheral artery disease 9.6
30 conduct disorder 9.6
31 personality disorder 9.6
32 vascular disease 9.6
33 cannabis dependence 9.6
34 larynx cancer 9.6
35 bruxism 9.6
36 adenocarcinoma 9.6
37 substance abuse 9.6
38 pneumonia 9.6
39 panic disorder 9.6
40 chronic pain 9.6
41 ring chromosome y syndrome 9.6
42 chronic enteropathy associated with slco2a1 gene 9.6

Graphical network of the top 20 diseases related to Smoking As a Quantitative Trait Locus 3:



Diseases related to Smoking As a Quantitative Trait Locus 3

Symptoms & Phenotypes for Smoking As a Quantitative Trait Locus 3

Clinical features from OMIM:

612052

GenomeRNAi Phenotypes related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.23 CHRNA3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.23 CHRNA3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.23 CHRNA5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.23 CHRNA5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.23 CHRNA5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.23 CHRNA3 CHRNA5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.23 CHRNA5

Drugs & Therapeutics for Smoking As a Quantitative Trait Locus 3

Search Clinical Trials , NIH Clinical Center for Smoking As a Quantitative Trait Locus 3

Genetic Tests for Smoking As a Quantitative Trait Locus 3

Genetic tests related to Smoking As a Quantitative Trait Locus 3:

# Genetic test Affiliating Genes
1 Smoking As a Quantitative Trait Locus 3 28 CHRNA3 CHRNA5

Anatomical Context for Smoking As a Quantitative Trait Locus 3

MalaCards organs/tissues related to Smoking As a Quantitative Trait Locus 3:

38
Lung

Publications for Smoking As a Quantitative Trait Locus 3

Articles related to Smoking As a Quantitative Trait Locus 3:

(show top 50) (show all 581)
# Title Authors Year
1
The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in multiple sclerosis. ( 28127518 )
2017
2
Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American. ( 28413702 )
2017
3
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. ( 26239294 )
2016
4
Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland. ( 27127891 )
2016
5
Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. ( 27327258 )
2016
6
An association between the PPARI+-L162V polymorphism and nicotine dependency among patients with schizophrenia. ( 27624431 )
2016
7
The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. ( 27490263 )
2016
8
Correlation between nicotine dependence and barriers to cessation between exclusive cigarette smokers and dual (water pipe) smokers among Arab Americans. ( 25674035 )
2015
9
Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. ( 25652844 )
2015
10
Early emerging nicotine dependence symptoms in adolescence predict daily smoking in young adulthood. ( 25840749 )
2015
11
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. ( 25555482 )
2015
12
Effect of variation in BDNF Val(66)Met polymorphism, smoking, and nicotine dependence on symptom severity of depressive and anxiety disorders. ( 25618300 )
2015
13
Nicotine Dependence, Physical Activity, and Sedentary Behavior among Adult Smokers. ( 25839000 )
2015
14
The contribution of rare and common variants in 30 genes to risk nicotine dependence. ( 25450229 )
2015
15
EFFECT OF CYP2A6*4 GENETIC POLYMORPHISMS ON SMOKING BEHAVIORS AND NICOTINE DEPENDENCE IN A GENERAL POPULATION OF JAPANESE MEN. ( 26370685 )
2015
16
An association between the use of hypnotics and quit status in the treatment of nicotine dependence with varenicline in bipolar disorder. ( 25627075 )
2015
17
Comparisons of three nicotine dependence scales in a multiethnic sample of young adult menthol and non-menthol smokers. ( 25744873 )
2015
18
A functional polymorphism in the interleukin-1beta and severity of nicotine dependence in male schizophrenia: A case-control study. ( 25858413 )
2015
19
Ethnic-specific genetic association of variants in the corticotropin-releasing hormone receptor 1 gene with nicotine dependence. ( 25802844 )
2015
20
The role of mesoaccumbens dopamine in nicotine dependence. ( 25638334 )
2015
21
Increased impulsivity in pathological gambling: Considering nicotine dependence. ( 25819174 )
2015
22
A hierarchical instrumental decision theory of nicotine dependence. ( 25655891 )
2015
23
Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers. ( 25826680 )
2015
24
CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence. ( 25489907 )
2015
25
A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. ( 26220977 )
2015
26
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. ( 26289589 )
2015
27
Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. ( 25632390 )
2015
28
T76. Baclofen as a Pharmacotherapy for the Treatment of Concurrent Alcohol and Nicotine Dependence: A Double-blind, Placebo-Controlled, Randomized Trial. ( 25868070 )
2015
29
Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. ( 26440539 )
2015
30
The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. ( 25640319 )
2015
31
The effects of nicotine dependence and acute abstinence on the processing of drug and non-drug rewards. ( 25757672 )
2015
32
Relationships Between Craving Beliefs and Abstinence Self-Efficacy are Mediated by Smoking Motives and Moderated by Nicotine Dependence. ( 25744968 )
2015
33
Elevated Risk of Nicotine Dependence Among Sib-pairs Discordant for Maternal Smoking During Pregnancy: Evidence from a 40-year Longitudinal Study. ( 25767988 )
2015
34
Reasons for smoking cessation attempts among Japanese male smokers vary by nicotine dependence level: a cross-sectional study after the 2010 tobacco tax increase. ( 25795690 )
2015
35
NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. ( 25273375 )
2014
36
Depression and anxiety symptoms moderate the relation between negative reinforcement smoking outcome expectancies and nicotine dependence. ( 25208195 )
2014
37
Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. ( 24927283 )
2014
38
Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data. ( 24590108 )
2014
39
Genetic Association of CHRNB3 and CHRNA6 Gene Polymorphisms with Nicotine Dependence Syndrome Scale in Korean Population. ( 25110504 )
2014
40
Nicotine dependence produces hyperalgesia: Role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA). ( 24107576 )
2014
41
The risk for persistent adult alcohol and nicotine dependence: the role of childhood maltreatment. ( 24401044 )
2014
42
Association of smoking and nicotine dependence with pre-diabetes in young and healthy adults. ( 25295968 )
2014
43
Nicotine-dependence-varying effects of smoking events on momentary mood changes among adolescents. ( 25306388 )
2014
44
Killing two birds with one stone: the potential role of aripiprazole for patients with comorbid major depressive disorder and nicotine dependence via altering brain activity in the anterior cingulate cortex. ( 25109873 )
2014
45
Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation. ( 23752091 )
2014
46
Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population. ( 25526961 )
2014
47
Nicotine dependence and biochemical exposure measures in the second trimester of pregnancy. ( 23943839 )
2014
48
Determining the causes and consequences of nicotine dependence: emerging genetic research methods. ( 25135777 )
2014
49
A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence. ( 24057800 )
2014
50
Genetic polymorphisms in glutathione-S-transferases are associated with anxiety and mood disorders in nicotine dependence. ( 24637631 )
2014

Variations for Smoking As a Quantitative Trait Locus 3

ClinVar genetic disease variations for Smoking As a Quantitative Trait Locus 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHRNA5 NM_000745.3(CHRNA5): c.1192G> A (p.Asp398Asn) single nucleotide variant risk factor rs16969968 GRCh37 Chromosome 15, 78882925: 78882925
2 CHRNA3 NM_001166694.1(CHRNA3): c.645C> T (p.Tyr215=) single nucleotide variant drug response rs1051730 GRCh37 Chromosome 15, 78894339: 78894339

Expression for Smoking As a Quantitative Trait Locus 3

Search GEO for disease gene expression data for Smoking As a Quantitative Trait Locus 3.

Pathways for Smoking As a Quantitative Trait Locus 3

GO Terms for Smoking As a Quantitative Trait Locus 3

Cellular components related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.26 CHRNA3 CHRNA5
2 synapse GO:0045202 9.16 CHRNA3 CHRNA5
3 postsynaptic membrane GO:0045211 8.96 CHRNA3 CHRNA5
4 acetylcholine-gated channel complex GO:0005892 8.62 CHRNA3 CHRNA5

Biological processes related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.37 CHRNA3 CHRNA5
2 transmembrane transport GO:0055085 9.32 CHRNA3 CHRNA5
3 ion transmembrane transport GO:0034220 9.26 CHRNA3 CHRNA5
4 excitatory postsynaptic potential GO:0060079 9.16 CHRNA3 CHRNA5
5 synaptic transmission, cholinergic GO:0007271 8.96 CHRNA3 CHRNA5
6 behavioral response to nicotine GO:0035095 8.62 CHRNA3 CHRNA5

Molecular functions related to Smoking As a Quantitative Trait Locus 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular ligand-gated ion channel activity GO:0005230 9.32 CHRNA3 CHRNA5
2 ligand-gated ion channel activity GO:0015276 9.26 CHRNA3 CHRNA5
3 acetylcholine binding GO:0042166 9.16 CHRNA3 CHRNA5
4 acetylcholine-gated cation-selective channel activity GO:0022848 8.96 CHRNA3 CHRNA5
5 acetylcholine receptor activity GO:0015464 8.62 CHRNA3 CHRNA5

Sources for Smoking As a Quantitative Trait Locus 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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