MCID: SMT002
MIFTS: 39

Smooth Muscle Tumor

Categories: Cancer diseases

Aliases & Classifications for Smooth Muscle Tumor

MalaCards integrated aliases for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 41 D018235
NCIt 46 C3751
SNOMED-CT 64 189799007 75109009
UMLS 69 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor is related to intravenous leiomyomatosis and leiomyoma, uterine. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Striated Muscle Contraction. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 intravenous leiomyomatosis 31.9 DES ESR1 MME
2 leiomyoma, uterine 31.9 ESR1 HMGA2 PGR
3 leiomyosarcoma 30.6 ACTC1 DES KIT PGR VIM
4 leiomyoma 30.0 ACTC1 DES ESR1 HMGA2 MME PGR
5 bizarre leiomyoma 29.7 ACTC1 PGR
6 cystadenoma 29.7 MME PGR
7 lymphangioleiomyomatosis 29.4 DES ESR1 PGR
8 fasciitis 29.0 ACTC1 DES VIM
9 adenosarcoma 28.6 DES ESR1 KIT MME PGR
10 gastrointestinal stromal tumor 28.5 ACTC1 DES KIT VIM
11 endometrial stromal sarcoma 27.9 ACTC1 DES ESR1 KIT MME PGR
12 perivascular epithelioid cell tumor 27.8 ACTC1 DES KIT MME PGR VIM
13 mixed endometrial stromal and smooth muscle tumor 12.4
14 rectum leiomyosarcoma 10.9
15 endometrial stromal nodule 10.5 MME PGR
16 clear cell meningioma 10.5 PGR VIM
17 spermatocele 10.4 MME PGR
18 retroperitoneal fibrosis 10.4 CCL11 VIM
19 breast angiosarcoma 10.4 KIT PGR
20 uterine body mixed cancer 10.4 KIT PGR
21 vulvar syringoma 10.4 ESR1 PGR
22 malignant leydig cell tumor 10.4 KIT MME
23 vestibular gland benign neoplasm 10.4 ESR1 PGR
24 lung leiomyoma 10.4 ESR1 PGR
25 bartholin's gland adenoma 10.4 ESR1 PGR
26 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
27 vulvar benign neoplasm 10.4 ESR1 PGR
28 rete testis adenocarcinoma 10.4 KIT MME
29 trigonitis 10.4 ESR1 PGR
30 vulvar leiomyoma 10.4 ESR1 PGR
31 predominantly cortical thymoma 10.4 ESR1 PGR
32 breast medullary carcinoma 10.4 ESR1 PGR
33 breast myofibroblastoma 10.4 ESR1 MME
34 breast scirrhous carcinoma 10.4 ESR1 PGR
35 mast-cell sarcoma 10.3 KIT VIM
36 progesterone resistance 10.3 ESR1 PGR
37 collecting duct carcinoma 10.3 MME VIM
38 progesterone-receptor positive breast cancer 10.3 ESR1 PGR
39 cervical adenoma malignum 10.3 HMGA2 MME
40 oncocytic breast carcinoma 10.3 ESR1 PGR
41 bartholin's gland benign neoplasm 10.3 ESR1 PGR
42 endometrial squamous cell carcinoma 10.3 ESR1 PGR
43 gastric signet ring cell adenocarcinoma 10.3 ESR1 PGR
44 deep angioma 10.3 ESR1 PGR
45 apocrine adenocarcinoma 10.3 ESR1 PGR
46 gender identity disorder 10.3 ESR1 PGR
47 synchronous bilateral breast carcinoma 10.3 ESR1 PGR
48 kimura disease 10.3 CCL11 CCR3
49 cervical mucinous adenocarcinoma 10.3 HMGA2 MME
50 corneal ulcer 10.3 CCL11 CCR3

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 ACTC1 VIM CCR3 DES ESR1 KIT
2 homeostasis/metabolism MP:0005376 9.86 VIM ACTC1 CCR3 DES ESR1 KIT
3 immune system MP:0005387 9.7 VIM CCL11 CCR3 ESR1 KIT MME
4 muscle MP:0005369 9.43 ACTC1 DES ESR1 KIT PGR VIM
5 respiratory system MP:0005388 9.02 VIM CCL11 CCR3 ESR1 KIT

Drugs & Therapeutics for Smooth Muscle Tumor

Drugs for Smooth Muscle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 2
3 Botulinum Toxins Phase 2
4 Botulinum Toxins, Type A Phase 2
5 Cholinergic Agents Phase 2
6 Neuromuscular Agents Phase 2
7 Neurotransmitter Agents Phase 2
8 onabotulinumtoxinA Phase 2
9 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
2 Surgery for Intravenous Leiomyomatosis Completed NCT01707862
3 The Role of Fibroblast Activation in Uterine Fibroid Not yet recruiting NCT03444987

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

38
Smooth Muscle, Uterus, Lung, Liver, Heart, Endothelial, Tonsil

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 179)
# Title Authors Year
1
Resolution of Multifocal Epstein-Barr Virus-Related Smooth Muscle Tumor in a Patient with GATA2 Deficiency Following Hematopoietic Stem Cell Transplantation. ( 27924436 )
2017
2
Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis. ( 28340268 )
2017
3
Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver. ( 28756985 )
2017
4
Uterine Smooth Muscle Tumor of Uncertain Malignant Potential: Clinicopathologic-Sonographic Characteristics, Follow-Up and Recurrence. ( 29147439 )
2017
5
Proposed novel nomenclature of vulvar smooth muscle tumors; a case of Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) of the vulva. ( 28180147 )
2017
6
Ellipsoid Smooth Muscle Tumor of the Lower Eyelid: An Exploration of Its Possible Origin. ( 28700399 )
2017
7
Epstein-Barr virus-associated smooth muscle tumor as the initial presentation of HIV infection: A case report. ( 28532583 )
2017
8
EBV-associated hepatic smooth muscle tumor of uncertain biologic behavior after heart transplantation in a pediatric patient: case report. ( 28280632 )
2017
9
Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential. ( 28004108 )
2017
10
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. ( 28623706 )
2017
11
PET/CT in an 8-Year-Old Girl With Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 28806251 )
2017
12
Epstein-Barr virus-associated iris smooth muscle tumor with epithelioid morphology in AIDS patients: a case report. ( 27099533 )
2016
13
Smooth Muscle Tumor Originating in the Pleura: A Case Report and Updated Literature Review. ( 27747117 )
2016
14
Morcellator's Port-site Metastasis of a Uterine Smooth Muscle Tumor of Uncertain Malignant Potential After Minimally Invasive Myomectomy. ( 26851127 )
2016
15
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. ( 26892441 )
2016
16
Successful pregnancy following myomectomy for uterine smooth muscle tumor of uncertain malignant potential: A case report and review of the literature. ( 26937476 )
2016
17
The role of fibroblast growth factor 2 in patients with uterine smooth muscle tumors: an immunohistochemical study. ( 27825029 )
2016
18
Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. ( 27341041 )
2016
19
Rare Presentations of Epstein-Barr Virus--Associated Smooth Muscle Tumor in Children. ( 26230054 )
2016
20
EMMPRIN (CD147) Expression in Smooth Muscle Tumors of the Uterus. ( 26352545 )
2016
21
Dome-shaped metastatic lesion on the scalp from a uterine smooth muscle tumor of uncertain malignant potential (STUMP). ( 27086706 )
2016
22
Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 27362573 )
2016
23
A clinicopathological study of atypical leiomyomas: Benign variant leiomyoma or smooth-muscle tumor of uncertain malignant potential. ( 26893755 )
2016
24
Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization. ( 27994831 )
2016
25
Lacrimal Sac Smooth Muscle Tumor of Uncertain Malignant Potential. ( 27306954 )
2016
26
Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. ( 25932961 )
2015
27
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors. ( 26472283 )
2015
28
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. ( 26045786 )
2015
29
Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. ( 25698060 )
2015
30
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. ( 26960523 )
2015
31
Mixed endometrial stromal and smooth muscle tumor with heart metastasis: report of a case and review of literature. ( 25755804 )
2015
32
Effects of Morcellation of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential and Endometrial Stromal Sarcoma: Case Series and Recommendations for Clinical Practice. ( 25596464 )
2015
33
Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma / smooth muscle tumor with uncertain malignant potential and benign leiomyoma. ( 26383110 )
2015
34
Expression of B23/Nucleophosphamine Nonribosomal Nucleolar Protein in Smooth Muscle Tumors of the Corpus Uteri. ( 26642792 )
2015
35
Two-stage resection of a disseminated mixed endometrial stromal sarcoma and smooth muscle tumor with intravascular and intracardiac extension. ( 26701002 )
2015
36
Epstein-Barr Virus-Associated Pulmonary Smooth Muscle Tumor After Lung Transplantation. ( 26046906 )
2015
37
High 18F-FDG uptake for uterine smooth muscle tumor of uncertain malignant potential. ( 25674868 )
2015
38
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
39
CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma. ( 25509988 )
2014
40
MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. ( 24196187 )
2014
41
The measurement of stiffness of uterine smooth muscle tumor by elastography. ( 25019043 )
2014
42
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. ( 24319862 )
2013
43
Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells. ( 23022018 )
2013
44
Mixed endometrial stromal and smooth muscle tumor: report of a case with focal anaplasia and early postoperative lung metastasis. ( 23692422 )
2013
45
Extrauterine mixed endometrial stromal-smooth muscle tumor: Report of an unusual entity. ( 24455616 )
2013
46
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. ( 24062958 )
2013
47
Completely infarcted smooth muscle tumor of the placental membrane. ( 23279350 )
2013
48
Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. ( 23517922 )
2013
49
Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature. ( 23701791 )
2013
50
Smooth muscle tumor of uncertain malignant potential of the urinary bladder: a case report and review of the literature. ( 23810438 )
2013

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

Pathways related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 CCR3 KIT MME
2 10.66 ACTC1 DES VIM
3 10.36 CCL11 DES KIT VIM

GO Terms for Smooth Muscle Tumor

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.93 CCL11 CCR3 ESR1 HMGA2 KIT PGR
2 positive regulation of gene expression GO:0010628 9.67 ACTC1 HMGA2 KIT VIM
3 positive regulation of angiogenesis GO:0045766 9.58 CCL11 CCR3 HMGA2
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.5 ESR1 HMGA2 KIT
5 response to radiation GO:0009314 9.48 CCL11 KIT
6 intermediate filament organization GO:0045109 9.43 DES VIM
7 positive regulation of phospholipase C activity GO:0010863 9.26 ESR1 KIT
8 mast cell chemotaxis GO:0002551 9.16 CCL11 KIT
9 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
10 stem cell differentiation GO:0048863 8.8 ESR1 HMGA2 KIT

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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