MCID: SMT002
MIFTS: 41

Smooth Muscle Tumor malady

Categories: Cancer diseases

Aliases & Classifications for Smooth Muscle Tumor

Aliases & Descriptions for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 52 42 14 69
Smooth Muscle Tumour of Uncertain Malignant Potential 12
Neoplasm of the Smooth Muscle 12
Smooth Muscle Tumor Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 42 D018235
NCIt 47 C3751
SNOMED-CT 64 189799007 75109009
UMLS 69 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor, also known as smooth muscle tumour of uncertain malignant potential, is related to endometrial stromal sarcoma and gastrointestinal stromal tumor. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Striated Muscle Contraction. The drugs Desflurane and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
id Related Disease Score Top Affiliating Genes
1 endometrial stromal sarcoma 30.4 PGR VIM
2 gastrointestinal stromal tumor 29.3 ACTC1 DES KIT VIM
3 adenosarcoma 29.2 ACTC1 DES KIT PGR VIM
4 mixed endometrial stromal and smooth muscle tumor 12.2
5 intravenous leiomyomatosis 11.3
6 leiomyosarcoma 11.2
7 leiomyoma 11.2
8 uterine fibroid 10.8
9 rectum leiomyosarcoma 10.8
10 central nervous system tuberculosis 10.3 MME PGR
11 papilloma 10.3 MME PGR
12 bile duct rhabdomyosarcoma 10.3 DES MME
13 panophthalmitis 10.3 MME PGR
14 pericardium leiomyoma 10.3 ACTC1 PGR
15 hydrarthrosis 10.3 ACTC1 PGR
16 testis sarcoma 10.3 DES KIT
17 oral erosive lichen 10.3 ACTC1 DES
18 skin angiosarcoma 10.3 KIT PGR
19 intestinal neuroendocrine benign tumor 10.3 KIT PGR
20 vagina leiomyosarcoma 10.3 ACTC1 DES
21 paranasal sinus cancer 10.3 KIT MME
22 sphenoid sinus squamous cell carcinoma 10.2 KIT MME
23 breast angiomatosis 10.2 ESR1 MME
24 bartholin's gland benign neoplasm 10.2 ESR1 PGR
25 cardiovascular organ benign neoplasm 10.2 ESR1 PGR
26 appendix leiomyoma 10.2 ESR1 PGR
27 bronchus adenoma 10.2 ESR1 PGR
28 glioma 10.2 ESR1 PGR
29 ovarian benign neoplasm 10.2 ESR1 PGR
30 plexiform neurofibroma 10.2 ESR1 PGR
31 paranasal sinus disease 10.2 ESR1 PGR
32 deafness, autosomal recessive 21 10.2 ESR1 PGR
33 inflammatory linear verrucous epidermal nevus 10.2 DES VIM
34 ovarian embryonal carcinoma 10.2 KIT PGR
35 cervical lymphoepithelioma-like carcinoma 10.2 ESR1 PGR
36 episodic ataxia 10.2 ACTC1 DES
37 histiocytic and dendritic cell cancer 10.2 ESR1 PGR
38 pediatric intraocular retinoblastoma 10.2 ESR1 PGR
39 congenital disorder of glycosylation, type ic 10.2 ESR1 PGR
40 her2-receptor negative breast cancer 10.2 ESR1 PGR
41 intestinal perforation 10.2 ESR1 PGR
42 subareolar duct papillomatosis 10.2 ESR1 MME
43 perlman syndrome 10.2 ESR1 PGR
44 nervous system hibernoma 10.2 ESR1 PGR
45 anal neuroendocrine tumor 10.2 ESR1 PGR
46 osteogenesis imperfecta 10.2 ESR1 PGR
47 intracranial sinus thrombosis 10.2 KIT VIM
48 biliary papillomatosis 10.2 DES VIM
49 poliomyelitis 10.2 ESR1 PGR
50 lymphomatoid papulosis 10.2 ACTC1 VIM

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 PGR VIM ACTC1 CCR3 DES ESR1
2 homeostasis/metabolism MP:0005376 9.86 ACTC1 CCR3 DES ESR1 KIT MME
3 immune system MP:0005387 9.7 CCL11 CCR3 ESR1 KIT MME PGR
4 muscle MP:0005369 9.43 ACTC1 DES ESR1 KIT PGR VIM
5 respiratory system MP:0005388 9.02 CCL11 CCR3 ESR1 KIT VIM

Drugs & Therapeutics for Smooth Muscle Tumor

Drugs for Smooth Muscle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desflurane Approved Phase 4 57041-67-5 42113
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5
Nitric Oxide Approved Phase 4 10102-43-9 145068
6 Neurotransmitter Agents Phase 4,Phase 2
7 Peripheral Nervous System Agents Phase 4,Phase 2
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Antiviral Agents Phase 4,Phase 2,Phase 1
10 Analgesics Phase 4,Phase 2
11 Anesthetics Phase 4,Phase 2
12 Anesthetics, General Phase 4,Phase 2
13 Anesthetics, Intravenous Phase 4,Phase 2
14 Central Nervous System Depressants Phase 4,Phase 2
15 Autonomic Agents Phase 4,Phase 2
16 Anesthetics, Dissociative Phase 4
17 Excitatory Amino Acid Antagonists Phase 4
18 Excitatory Amino Acids Phase 4
19 Vasodilator Agents Phase 4,Phase 2
20 Anti-Asthmatic Agents Phase 4
21 Antidotes Phase 4
22 Antioxidants Phase 4
23 Bronchodilator Agents Phase 4
24 Endothelium-Dependent Relaxing Factors Phase 4
25 Expectorants Phase 4
26 N-monoacetylcystine Phase 4
27 Protective Agents Phase 4
28 Respiratory System Agents Phase 4
29 arginine Nutraceutical Phase 4
30
Everolimus Approved Phase 3 159351-69-6 6442177
31
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
32
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
33
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
34
Simvastatin Approved Phase 3 79902-63-9 54454
35 Anti-Bacterial Agents Phase 3,Phase 2
36 Antibiotics, Antitubercular Phase 3
37 Antifungal Agents Phase 3
38 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
39 Antimetabolites Phase 3,Phase 2,Phase 1
40 Contraceptive Agents Phase 3
41 Contraceptives, Oral Phase 3
42 Contraceptives, Postcoital Phase 3
43 Hormone Antagonists Phase 3
44 Hormones Phase 3
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
46 Luteolytic Agents Phase 3
47 Anticholesteremic Agents Phase 3
48 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
49 Hypolipidemic Agents Phase 3
50 Lipid Regulating Agents Phase 3

Interventional clinical trials:

(show all 32)
id Name Status NCT ID Phase
1 Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation Recruiting NCT02962999 Phase 4
2 N-Acetylcysteine and Arginine Administration in Diabetic Patients Terminated NCT00569465 Phase 4
3 Efficacy and Safety of Sirolimus for Treating Lymphangioleiomyomatosis (LAM) Unknown status NCT00414648 Phase 3
4 Molecular and Clinical Effects of Green Tea and Fermented Papaya Preparation on Diabetes and Cardiovascular Diseases Completed NCT01248143 Phase 2, Phase 3
5 Trial of Mifepristone for Fibroids Completed NCT00133705 Phase 3
6 The Effect of Simvastatin on Uterine Leiomyoma Development and Growth in Infertile Women Recruiting NCT03134157 Phase 3
7 The Value of Botox-A for Management of Low Anterior Resection Syndrome Unknown status NCT01589471 Phase 2
8 Efficacy of Prazosin Versus Placebo Associated With Peg-Interferon Alpha 2b and Ribavirin in Chronic Hepatitis C With Genotype 1 or 4 and Severe Fibrosis Unknown status NCT00148837 Phase 2
9 "BP as a New Device for Surgery and Solid Cancer and Hematopoietic System Tumors Treatment. Effects of BP Implantation" Unknown status NCT02328352 Phase 1, Phase 2
10 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
11 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
12 Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect Completed NCT00121563 Phase 2
13 Nintedanib(BIBF1120) in Thyroid Cancer Recruiting NCT01788982 Phase 2
14 Trimetazidine in Pulmonary Artery Hypertension Recruiting NCT02102672 Phase 2
15 Restoring the Beneficial Effects of Enterohepatic Bile Salt Signalling by Chyme Reinfusion in Patients With a Double Enterostomy Recruiting NCT02990195 Phase 2
16 Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma Not yet recruiting NCT03123276 Phase 1, Phase 2
17 Clinical Trial Of Neoadjuvant Chemotherapy (NAC)In Upper Tract Urothelial Carcinoma (UTUC) Terminated NCT01663285 Phase 2
18 Can Fat Derived Stem Cells (SVF) be Used in the Treatment of Erectile Dysfunction After Prostatectomy Active, not recruiting NCT02240823 Phase 1
19 Investigation of the Suburothelial Myofibroblast Network and of Smooth Muscle Function and Control in the Human Urinary Outflow Tract Unknown status NCT01227447
20 Correlation Between Vitamin D Levels to ADAMTS13 , VWF and Micro RNA Expression in Diabetic Hemodialysis Patients Unknown status NCT02245633
21 BP as a Super-light Mesh and as a New Fixation Device for General Surgery -DM108/2008-B Unknown status NCT02341222 Early Phase 1
22 Surgery for Intravenous Leiomyomatosis Completed NCT01707862
23 Controlled Clinical Trial to Determine the Effective Dose of Cocoa in Lowering Blood Pressure Completed NCT01276951
24 Personalized Asthma Care Team Completed NCT01423461
25 Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer Recruiting NCT00050752
26 WISE CVD - Continuation (WISE HFpEF) Recruiting NCT02582021
27 Study of the Disease Process of Lymphangioleiomyomatosis Recruiting NCT00001465
28 Effect of Different Exercises on Quality of Life of Leukemia Patients. Recruiting NCT03147365
29 Effectiveness of Myofascial Release Versus Manual Lymphatic Drainage After Breast Cancer Surgery Recruiting NCT03182881
30 Comparison of Safety and Efficacy of Detaenial Sigmoid Neobladder and Ileal Neobladder Enrolling by invitation NCT03108196
31 Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study Not yet recruiting NCT02873182
32 Anatomical and Functional Differences Between Continent and Incontinent Men Post Radical Prostatectomy Terminated NCT01832831

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

39
Smooth Muscle, Uterus, Lung, Liver, Placenta, Prostate, Tonsil

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 170)
id Title Authors Year
1
Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential. ( 28004108 )
2017
2
Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis. ( 28340268 )
2017
3
Resolution of Multifocal Epstein-Barr Virus-Related Smooth Muscle Tumor in a Patient with GATA2 Deficiency Following Hematopoietic Stem Cell Transplantation. ( 27924436 )
2017
4
EMMPRIN (CD147) Expression in Smooth Muscle Tumors of the Uterus. ( 26352545 )
2016
5
Morcellator's Port-site Metastasis of a Uterine Smooth Muscle Tumor of Uncertain Malignant Potential After Minimally Invasive Myomectomy. ( 26851127 )
2016
6
Dome-shaped metastatic lesion on the scalp from a uterine smooth muscle tumor of uncertain malignant potential (STUMP). ( 27086706 )
2016
7
Epstein-Barr virus-associated iris smooth muscle tumor with epithelioid morphology in AIDS patients: a case report. ( 27099533 )
2016
8
Lacrimal Sac Smooth Muscle Tumor of Uncertain Malignant Potential. ( 27306954 )
2016
9
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. ( 26892441 )
2016
10
Smooth Muscle Tumor Originating in the Pleura: A Case Report and Updated Literature Review. ( 27747117 )
2016
11
Successful pregnancy following myomectomy for uterine smooth muscle tumor of uncertain malignant potential: A case report and review of the literature. ( 26937476 )
2016
12
Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. ( 27341041 )
2016
13
A clinicopathological study of atypical leiomyomas: Benign variant leiomyoma or smooth-muscle tumor of uncertain malignant potential. ( 26893755 )
2016
14
Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 27362573 )
2016
15
Rare Presentations of Epstein-Barr Virus--Associated Smooth Muscle Tumor in Children. ( 26230054 )
2016
16
Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization. ( 27994831 )
2016
17
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors. ( 26472283 )
2015
18
Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. ( 25698060 )
2015
19
Expression of B23/Nucleophosphamine Nonribosomal Nucleolar Protein in Smooth Muscle Tumors of the Corpus Uteri. ( 26642792 )
2015
20
Effects of Morcellation of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential and Endometrial Stromal Sarcoma: Case Series and Recommendations for Clinical Practice. ( 25596464 )
2015
21
Two-stage resection of a disseminated mixed endometrial stromal sarcoma and smooth muscle tumor with intravascular and intracardiac extension. ( 26701002 )
2015
22
High 18F-FDG uptake for uterine smooth muscle tumor of uncertain malignant potential. ( 25674868 )
2015
23
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. ( 26045786 )
2015
24
Mixed endometrial stromal and smooth muscle tumor with heart metastasis: report of a case and review of literature. ( 25755804 )
2015
25
Epstein-Barr Virus-Associated Pulmonary Smooth Muscle Tumor After Lung Transplantation. ( 26046906 )
2015
26
Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma / smooth muscle tumor with uncertain malignant potential and benign leiomyoma. ( 26383110 )
2015
27
Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. ( 25932961 )
2015
28
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. ( 26960523 )
2015
29
MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. ( 24196187 )
2014
30
CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma. ( 25509988 )
2014
31
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
32
The measurement of stiffness of uterine smooth muscle tumor by elastography. ( 25019043 )
2014
33
Multifocal Histologically Malignant Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Pediatric Transplant Patient With an Indolent Course. ( 23842005 )
2013
34
Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. ( 23517922 )
2013
35
Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells. ( 23022018 )
2013
36
Completely infarcted smooth muscle tumor of the placental membrane. ( 23279350 )
2013
37
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. ( 24062958 )
2013
38
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. ( 24319862 )
2013
39
Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature. ( 23701791 )
2013
40
Mixed endometrial stromal and smooth muscle tumor: report of a case with focal anaplasia and early postoperative lung metastasis. ( 23692422 )
2013
41
Smooth muscle tumor of uncertain malignant potential of the urinary bladder: a case report and review of the literature. ( 23810438 )
2013
42
MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. ( 23225304 )
2013
43
Extrauterine mixed endometrial stromal-smooth muscle tumor: Report of an unusual entity. ( 24455616 )
2013
44
Myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Case report. ( 22716064 )
2012
45
Epstein-Barr virus-associated smooth muscle tumor of the tonsil. ( 21885224 )
2012
46
Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. ( 22217299 )
2012
47
Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules. ( 23248426 )
2012
48
Periurethral smooth muscle tumor of undetermined malignant potential. ( 22720177 )
2012
49
Uterine smooth muscle tumors of uncertain malignant potential and atypical leiomyoma: a morphological study of these grey zones with clinical correlation. ( 22234095 )
2011
50
Multifocal vulvar smooth muscle tumor with an unusual intravascular growth pattern and multiple local recurrences in a 10-year-old child: a diagnostic dilemma. ( 21090988 )
2011

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

Pathways related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.2 CCR3 KIT MME
2 10.66 ACTC1 DES VIM

GO Terms for Smooth Muscle Tumor

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.93 CCL11 CCR3 ESR1 HMGA2 KIT PGR
2 positive regulation of gene expression GO:0010628 9.62 ACTC1 HMGA2 KIT VIM
3 male gonad development GO:0008584 9.58 ESR1 HMGA2 KIT
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.54 ESR1 HMGA2 KIT
5 response to radiation GO:0009314 9.48 CCL11 KIT
6 intermediate filament organization GO:0045109 9.43 DES VIM
7 positive regulation of phospholipase C activity GO:0010863 9.26 ESR1 KIT
8 mast cell chemotaxis GO:0002551 9.16 CCL11 KIT
9 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
10 stem cell differentiation GO:0048863 8.8 ESR1 HMGA2 KIT

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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