MCID: SMT002
MIFTS: 55

Smooth Muscle Tumor malady

Cancer diseases category

Summaries for Smooth Muscle Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Smooth muscle tumours show a smooth muscle differentiation. There are two main types of smooth muscle... more...

MalaCards: Smooth Muscle Tumor, also known as smooth muscle tumour of uncertain malignant potential, is related to leiomyosarcoma and leiomyoma. An important gene associated with Smooth Muscle Tumor is DES (desmin), and among its related pathways are Advanced glycosylation endproduct receptor signaling and G2 Phase. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and lung, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Smooth Muscle Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

smooth muscle tumor 8 10 44 60
smooth muscle tumour of uncertain malignant potential 8
neoplasm of the smooth muscle 8
smooth muscle tumor nos 8


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Disease Ontology8 DOID:4310
NCIt39 C3751
SNOMED-CT56 75109009, 189799007
MeSH34 D018235

Related Diseases for Smooth Muscle Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma30.9ACTC1, KIT, MME, PGR, CDK2, IGF2
2leiomyoma30.8ACTC1, HMGA2, KIT, MME, PGR, PCNA
3endometrial stromal sarcoma30.7ACTC1, KIT, MME, PGR, DES, VIM
4sarcoma30.7ACTC1, HMGA2, KIT, CDK2, MKI67, IGF2
5gastrointestinal stromal tumor30.4ACTC1, KIT, PCNA, MKI67, DES, S100A1
6esophagitis30.3CCL11
7hepatitis30.3CCL11
8cystadenoma30.1MME
9leiomyomatosis30.1PGR
10fasciitis30.1ACTC1
11lymphangioleiomyomatosis30.1PGR, DES
12uterine fibroid30.1HMGA2, PGR
13leukemia30.1HMGA2, KIT, NME1, MME, CDK2, CR2
14adenocarcinoma30.1LGALS3, ACTC1, HMGA2, NME1, MME, PGR
15breast cancer30.1LGALS3, HMGA2, KIT, NME1, MME, PGR
16endometrial stromal tumor10.6
17mixed endometrial stromal and smooth muscle tumor10.5
18intravenous leiomyomatosis10.2
19acquired immunodeficiency syndrome10.2
20hepatitis a10.2
21uterus leiomyosarcoma10.2
22alport syndrome10.1
23esophagus leiomyoma10.1
24perivascular epithelioid cell tumor10.1
25clear cell adenocarcinoma10.1
26common variable immunodeficiency10.1
27larynx leiomyosarcoma10.1
28conventional leiomyosarcoma10.1
29tonsillitis10.1
30uterus perivascular epithelioid cell tumor10.1
31diffuse large b-cell lymphoma10.1
32laryngitis10.1
33mesenchymal cell neoplasm10.1
34ovary adenocarcinoma10.1
35perivascular tumor10.1
36prostatitis10.1
37vitamin b12 deficiency10.1
38uterine carcinosarcoma10.0KIT
39germ cell tumors10.0KIT
40ductal carcinoma in situ10.0PGR
41sinusitis10.0CCL11
42neuroblastoma10.0NME1
43li-fraumeni syndrome10.0PGR
44hemangioma10.0ACTC1
45infantile myofibromatosis10.0DES
46histiocytosis10.0S100B
47hemangioblastoma10.0S100B
48thymus cancer10.0KIT
49skin melanoma10.0NME1
50renal oncocytoma10.0S100A1

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to smooth muscle tumor

Clinical Features for Smooth Muscle Tumor

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Drugs & Therapeutics for Smooth Muscle Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Smooth Muscle Tumor

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Anatomical Context for Smooth Muscle Tumor

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32MalaCards
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MalaCards organs/tissues related to Smooth Muscle Tumor:

32
Smooth muscle, Uterus, Lung, Endothelial, Liver, Monocytes, Ovary, Breast, Skin, B cells, Tonsil, Prostate, Placenta, Bone, Salivary gland, Kidney, Colon, Spleen, Pituitary

Animal Models for Smooth Muscle Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Smooth Muscle Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.2IGF2, CDK2, ACTC1
2MP:000537610.1CR2, DES, IGF2, PGR, HMGA2, ACTC1
3MP:000537910.1HMGA2, KIT, NME1, CDK2
4MP:001077110.0S100B, IGF2, CDK2, MME, NME1, HMGA2
5MP:00053899.9CDK2, PCNA
6MP:00053979.6CCL11, CCNA2, CR2, IGF2, CDK2, PCNA
7MP:00053859.6VIM, S100A1, DES, IGF2, CDK2, PGR
8MP:00053879.5VIM, CCL11, CCNA2, CR2, IGF2, CDK2
9MP:00107689.4LGALS3, VIM, CCNA2, CALD1, CR2, DES
10MP:00053849.4VIM, CCNA2, CR2, IGF2, CDK2, PCNA

Publications for Smooth Muscle Tumor

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50PubMed
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Articles related to Smooth Muscle Tumor:

(show top 50)    (show all 251)
idTitleAuthorsYear
1
Twist1 in tumor cells and I+-smooth muscle actin in stromal cells are possible biomarkers for metastatic giant basal cell carcinoma. (23683049)
2013
2
Multifocal vulvar smooth muscle tumor with an unusual intravascular growth pattern and multiple local recurrences in a 10-year-old child: a diagnostic dilemma. (21090988)
2011
3
Epstein-Barr Virus-Associated Adrenal Smooth Muscle Tumors and Disseminated Diffuse Large B-Cell Lymphoma in a Child With Common Variable Immunodeficiency: A Case Report and Review of the Literature. (21454372)
2011
4
Retroperitoneal smooth muscle tumor of uncertain malignant potential after hysterectomy: a case report. (21619667)
2011
5
The phosphatidylinositol 3' kinase-Akt-mammalian target of rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and their clinicopathologic implications. (21464729)
2011
6
alpha-Smooth Muscle Actin Expressing Stroma Promotes an Aggressive Tumor Biology in Pancreatic Ductal Adenocarcinoma. (20467342)
2010
7
Genistein suppresses tumor necrosis factor-alpha-induced proliferation via the apoptotic signaling pathway in human aortic smooth muscle cells. (20067268)
2010
8
7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. (18515973)
2009
9
Transforming growth factor beta1-mediated activation of the smooth muscle alpha-actin gene in human pulmonary myofibroblasts is inhibited by tumor necrosis factor-alpha via mitogen-activated protein kinase kinase 1-dependent induction of the Egr-1 transcriptional repressor. (19261809)
2009
10
A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors. (19734847)
2009
11
Pseudo-Meigs' syndrome caused by uterine smooth muscle tumor of uncertain malignant potential with low vascular endothelial growth factor expression. (17944915)
2008
12
The importance of CD10 and h-Caldesmon in the distinction of smooth muscle tumors of the uterus and endometrial stromal sarcoma. (18813428)
2008
13
Laryngeal epithelioid smooth muscle tumor of low malignant potential. (17599590)
2007
14
Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. (17584970)
2007
15
Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells. (17368523)
2007
16
Role of NAD(P)H:quinone oxidoreductase 1 on tumor necrosis factor-alpha-induced migration of human vascular smooth muscle cells. (17669387)
2007
17
Epstein-Barr virus-associated smooth muscle tumor presenting as a vulvar mass in an acquired immunodeficiency syndrome patient: a case report. (17511803)
2007
18
Low grade malignant peripheral nerve sheath tumor with smooth muscle differentiation. (17119986)
2007
19
Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. (16394014)
2006
20
Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells. (16563235)
2006
21
Dedifferentiated mixed stromal-smooth muscle tumor of the uterus. Report of a case. (16715633)
2006
22
Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors. (15377824)
2005
23
G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. (16228299)
2005
24
Expression of matrix metalloproteinases in patients with uterine smooth muscle tumors: an immunohistochemical analysis of MMP-1 and MMP-2 protein expression in leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051038)
2004
25
Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway. (15266023)
2004
26
Uterine smooth-muscle tumor of uncertain malignant potential metastasizing to the humerus as a high-grade leiomyosarcoma. (15350379)
2004
27
cAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular smooth muscle cell migration. (15242860)
2004
28
Dual functionality of cyclooxygenase-2 as a regulator of tumor necrosis factor-mediated G1 shortening and nitric oxide-mediated inhibition of vascular smooth muscle cell proliferation. (12912810)
2003
29
Perivascular epithelioid cell tumor ('PEComa') of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors. (11756764)
2002
30
Esophageal smooth muscle tumor in a 25-year-old woman with congenital malformations. (11686481)
2001
31
Intraplacental smooth muscle tumor: a case report. (11444205)
2001
32
Tumor necrosis factor-alpha induces fibronectin synthesis in coronary artery smooth muscle cells by a nitric oxide-dependent posttranscriptional mechanism. (11440974)
2001
33
Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors. (11127756)
2000
34
Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-alpha-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells. (10669634)
2000
35
Involvement of cyclins in cell proliferation and their clinical implications in soft tissue smooth muscle tumors. (10854234)
2000
36
Endoscopic features of intestinal smooth muscle tumor in a child with AIDS. (10235596)
1999
37
Fas and Fas ligand expression in tumor cells and in vascular smooth-muscle cells of colonic and renal carcinomas. (10328232)
1999
38
Benefits of endorectal ultrasound for management of smooth-muscle tumor of the rectum: report of three cases. (10458136)
1999
39
Expression of nm23 in gastrointestinal smooth muscle tumors and its relation to cell proliferative activity]. (11825432)
1998
40
Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. (9546431)
1998
41
Clear-cell smooth muscle tumor of the skin. (9796734)
1998
42
Benign and malignant smooth muscle tumors containing Epstein-Barr virus in children with AIDS. (9402327)
1997
43
Smooth muscle tumors associated with X-linked Alport syndrome: carrier detection in females. (8587250)
1995
44
Proliferating-cell nuclear antigen immunocytochemistry in the evaluation of gastrointestinal smooth-muscle tumors. (7824513)
1994
45
Atypical myxoid smooth muscle tumor of the prostate: ERUS, CDI, and MR findings. (7950831)
1994
46
Tumor necrosis factor alpha-induced alteration of glycosaminoglycans in cultured vascular smooth-muscle cells. (8452875)
1993
47
Cloning of a mu-class glutathione S-transferase complementary DNA and characterization of its glucocorticoid inducibility in a smooth muscle tumor cell line. (1944302)
1991
48
Insulin-like growth factor gene expression in human smooth muscle tumors. (2208134)
1990
49
Glomus tumor cells: evaluation of smooth muscle and endothelial cell properties. (6137102)
1983
50
Vitamin B12 deficiency and lack of intrinsic factor associated with a smooth muscle tumor of the stomach. Remission after surgery. (4436038)
1974

Genetic Variations for Smooth Muscle Tumor

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Expression for genes affiliated with Smooth Muscle Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Smooth Muscle Tumor

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Pathways for genes affiliated with Smooth Muscle Tumor

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Smooth Muscle Tumor

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CR2
2cycloheximide4410.7MME
3butyrate4410.6CCL11, CDK2
4orcein4410.4DES, S100B, ACTC1, VIM
5mucicarmine4410.4DES, S100A1, VIM, ACTC1, S100B
6reticulin4410.3DES, PCNA, S100B, ACTC1, VIM
7glycogen44 2411.3CCNA2, IGF2, MKI67, CDK2, KIT, ACTC1
8creatinine4410.3ACTC1, NME1, MME, CDK2, IGF2
9s 1004410.3DES, S100B, ACTC1, VIM
10glutamine4410.3CDK2, IGF2, LGALS3, NME1, PCNA
11tamoxifen44 49 28 1113.3MKI67, IGF2, CDK2, PGR, CCNA2
12b 7234410.3VIM, ACTC1, S100B, S100A1, DES, PCNA
13paclitaxel44 49 1112.3CDK2, S100B, IFI27, IGF2, CCNA2, PGR
14serine4410.2DES, CCNA2, S100B, MKI67, NME1
15eb 108944 5911.2CCNA2, IFI27, IGF2, CDK2, PCNA
16etoposide44 49 59 1113.2VIM, CCNA2, LGALS3, IGF2, S100B, CDK2
17biotin44 11 2412.1ACTC1, MKI67, DES, S100A1, VIM, NME1
18steroid4410.1DES, IFI27, CCNA2, MKI67, NME1, ACTC1
19cytarabine44 49 1112.1CCNA2, VIM, MME, KIT, CDK2, IFI27
20formaldehyde44 2411.1ACTC1, KIT, PCNA, MKI67, DES, S100B
212-methoxyethanol4410.1S100A1, ACTC1, VIM, IGF2
22indomethacin44 59 28 1113.0IGF2, PGR, PCNA
235fluorouracil4410.0IGF2, CCNA2, MKI67, CDK2, PCNA, KIT
24p0024410.0MKI67, IGF2, DES, IFI27, NME1, KIT
25cyclosporin a44 28 5911.9CDK2, PCNA, PGR, CR2, S100B, CCNA2
26dexamethasone44 49 28 1112.9CCNA2, MME, PCNA, CDK2, IGF2, S100B
27actinomycin d449.9HMGA2, IGF2, VIM, MME, KIT, CCL11
28thymidylate449.9CDK2, VIM, CCNA2, MKI67, IFI27, PCNA
29hematoxylin449.9VIM, CR2, DES, MKI67, PCNA, KIT
30bromodeoxyuridine449.9S100B, CCNA2, IFI27, DES, MKI67, VIM
31doxorubicin44 49 1111.9HMGA2, DES, KIT, MME, PGR, MKI67
32cisplatin44 49 59 1112.8CDK2, IFI27, IGF2, MKI67, PCNA, NME1
33estradiol44 11 2411.8PCNA, VIM, CCNA2, IFI27, MKI67, PGR
34nitric oxide44 11 2411.8KIT, CCL11, CCNA2, S100B, S100A1, DES
35lactate449.8KIT, LGALS3, NME1, MME, PCNA, MKI67
36methionine449.8IFI27, VIM, KIT, MME, CDK2, DES
37threonine449.8CR2, DES, LGALS3, IFI27, CCNA2, CCL11
38alanine449.7VIM, CCNA2, CDK2, NME1, PGR, PCNA
39thymidine44 2410.7MKI67, IGF2, DES, S100B, IFI27, CCNA2
40cysteine449.7NME1, KIT, LGALS3, MME, PCNA, PGR
41arginine449.7IGF2, DES, MME, PCNA, CDK2, MKI67
42roscovitine449.6PCNA, CCNA2, CDK2, IFI27, VIM
43oxygen44 2410.6CDK2, MME, MKI67, LGALS3, DES, S100B
44testosterone44 59 11 2412.6S100B, DES, IGF2, MKI67, IFI27, CCNA2
45calcium44 49 11 2412.5CR2, CCL11, CALD1, IFI27, S100B, S100A1
46tyrosine449.4CCL11, CCNA2, IFI27, S100B, ACTC1, S100A1
47vegf449.3S100B, IGF2, DES, IFI27, CCNA2, CCL11
48progesterone44 59 28 11 2413.3LGALS3, ACTC1, KIT, NME1, MME, PGR
49paraffin449.2MME, NME1, KIT, HMGA2, ACTC1, LGALS3
50retinoic acid44 2410.1HMGA2, KIT, NME1, MME, PGR, PCNA

GO Terms for genes affiliated with Smooth Muscle Tumor

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16Gene Ontology
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Cellular components related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057379.3LGALS3, CCNA2, S100B, MKI67, CDK2, PCNA

Biological processes related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic G2 DNA damage checkpointGO:00709510.3HMGA2, CCNA2
2muscle filament slidingGO:03004910.1ACTC1, DES, VIM
3mast cell chemotaxisGO:00255110.0KIT, CCL11

Molecular functions related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.3S100A1, S100B
2identical protein bindingGO:0428029.6VIM, S100B, S100A1, DES, PCNA, NME1
3protein bindingGO:0055158.7LGALS3, VIM, CCL11, CCNA2, S100B, S100A1

Products for genes affiliated with Smooth Muscle Tumor

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Sources for Smooth Muscle Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet