MCID: SMT002
MIFTS: 46

Smooth Muscle Tumor malady

Muscle diseases, Cancer diseases categories

Summaries for Smooth Muscle Tumor

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66Wikipedia, 34MalaCards
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Wikipedia:66 Smooth muscle tumours show a smooth muscle differentiation. There are two main types of smooth muscle... more...

MalaCards: Smooth Muscle Tumor, also known as smooth muscle tumour of uncertain malignant potential, is related to leiomyosarcoma and endometrial stromal sarcoma. An important gene associated with Smooth Muscle Tumor is CR2 (complement component (3d/Epstein Barr virus) receptor 2), and among its related pathways is Striated Muscle Contraction. The compounds streptavidin and orcein have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and liver, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Smooth Muscle Tumor

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Muscle diseases


Aliases & Descriptions:

smooth muscle tumor 9 11 46 63
smooth muscle tumour of uncertain malignant potential 9
neoplasm of the smooth muscle 9
smooth muscle tumor nos 9


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Disease Ontology9 DOID:4310
NCIt41 C3751
SNOMED-CT59 189799007, 75109009
MeSH36 D018235

Related Diseases for Smooth Muscle Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.0DES, CCL11, ACTC1, CR2
2endometrial stromal sarcoma30.8ACTC1, DES
3leiomyoma30.8DES, CCL11, ACTC1, CR2, HMGA2
4sarcoma30.6DES, CCNA2, ACTC1, CR2, HMGA2
5fasciitis30.3ACTC1
6gastrointestinal stromal tumor30.2DES, ACTC1
7b-cell lymphomas30.1HMGA2, CR2, CCNA2
8breast cancer30.1NME1, ACTC1, CCNA2
9adenocarcinoma30.0CCNA2, ACTC1, NME1, HMGA2
10leukemia30.0CCNA2, CCL11, CR2, NME1, HMGA2
11mixed endometrial stromal and smooth muscle tumor10.4
12acquired immunodeficiency syndrome10.3
13intravenous leiomyomatosis10.3
14esophagitis10.3
15hepatitis10.3
16cystadenoma10.1
17perivascular epithelioid cell tumor10.1
18alport syndrome10.1
19rectum leiomyosarcoma10.1
20tonsillitis10.1
21lymphangioleiomyomatosis10.1
22common variable immunodeficiency10.1
23diffuse large b-cell lymphoma10.1
24endometrial stromal tumor10.1
25laryngitis10.1
26leiomyomatosis10.1
27prostatitis10.1
28vitamin b12 deficiency10.1
29glucocorticoid resistance10.1
30hiv/aids10.1
31endotheliitis10.1
32pseudo-meigs syndrome10.1
33meigs syndrome10.1
34infantile myofibromatosis10.1DES
35pleomorphic adenoma10.1HMGA2
36lipomatosis10.1HMGA2
37epithelioid leiomyosarcoma10.1ACTC1, DES
38pseudosarcomatous fibromatosis10.1DES, ACTC1
39dedifferentiated liposarcoma10.1HMGA2, DES
40spindle cell carcinoma10.1ACTC1, DES
41spindle cell sarcoma10.1ACTC1, DES
42desmoid tumor10.1DES, ACTC1
43cutaneous fibrous histiocytoma10.1ACTC1, DES
44adenosarcoma10.1ACTC1, DES
45dermatofibrosarcoma protuberans10.1DES, ACTC1
46fibrous histiocytoma10.1DES, ACTC1
47rhabdoid tumor10.1ACTC1, DES
48hemangiopericytoma10.0DES, ACTC1
49angiomyolipoma10.0ACTC1, DES
50glomus tumor10.0DES, ACTC1

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to smooth muscle tumor

Symptoms for Smooth Muscle Tumor

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Drugs & Therapeutics for Smooth Muscle Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Smooth Muscle Tumor

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Anatomical Context for Smooth Muscle Tumor

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34MalaCards
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MalaCards organs/tissues related to Smooth Muscle Tumor:

34
Smooth muscle, Uterus, Liver, Lung, Bone, B cells, Tonsil, Prostate, Placenta, Ovary, Skin, Breast, Spleen, Endothelial

Animal Models for Smooth Muscle Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Smooth Muscle Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMGA2, NME1, CR2, ACTC1, DES

Publications for Smooth Muscle Tumor

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53PubMed
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Articles related to Smooth Muscle Tumor:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. (24062958)
2013
2
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. (24319862)
2013
3
Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. (23517922)
2013
4
Completely infarcted smooth muscle tumor of the placental membrane. (23279350)
2013
5
Periurethral smooth muscle tumor of undetermined malignant potential. (22720177)
2012
6
Epstein-Barr virus-associated smooth muscle tumor of the tonsil. (21885224)
2012
7
Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. (22217299)
2012
8
Multifocal vulvar smooth muscle tumor with an unusual intravascular growth pattern and multiple local recurrences in a 10-year-old child: a diagnostic dilemma. (21090988)
2011
9
Epstein-Barr Virus-Associated Adrenal Smooth Muscle Tumors and Disseminated Diffuse Large B-Cell Lymphoma in a Child With Common Variable Immunodeficiency: A Case Report and Review of the Literature. (21454372)
2011
10
Retroperitoneal smooth muscle tumor of uncertain malignant potential after hysterectomy: a case report. (21619667)
2011
11
"Low-grade leiomyosarcoma" and late-recurring smooth muscle tumors of the uterus: a heterogenous collection of frequently misdiagnosed tumors associated with an overall favorable prognosis relative to conventional uterine leiomyosarcomas. (21921786)
2011
12
Rapid recurrence of uterine smooth muscle tumor of uncertain malignant potential as leiomyosarcoma. (21457977)
2011
13
Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient. (19659510)
2010
14
Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report. (19830174)
2009
15
Expression of EBV latent antigens, mammalian target of rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: clinical and therapeutic implications. (19706821)
2009
16
Uterine smooth muscle tumor of uncertain malignant potential: a three-case report. (17986240)
2008
17
Pseudo-Meigs' syndrome caused by uterine smooth muscle tumor of uncertain malignant potential with low vascular endothelial growth factor expression. (17944915)
2008
18
Multifocal Epstein-Barr virus-associated smooth muscle tumor in adults with AIDS: case report and review of the literature. (18714165)
2008
19
Laryngeal epithelioid smooth muscle tumor of low malignant potential. (17599590)
2007
20
Epstein-Barr virus-associated smooth muscle tumor in patients with acquired immunodeficiency syndrome. (17446968)
2007
21
Endoscopic management of gastrointestinal smooth muscle tumor. (17828822)
2007
22
Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. (17550381)
2007
23
Analysis of allelic loss as an adjuvant tool in evaluation of malignancy in uterine smooth muscle tumors. (16330948)
2006
24
Primary smooth muscle tumor of the pleura: a clinicopathological case report with ultrastructural observations and a review of the literature. (16257865)
2005
25
Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors. (15377824)
2005
26
A 40-year-old woman with multiple uterine masses. Stromomyoma--mixed endometrial stromal-smooth muscle tumor of the uterus. (16329742)
2005
27
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
28
Expression of matrix metalloproteinases in patients with uterine smooth muscle tumors: an immunohistochemical analysis of MMP-1 and MMP-2 protein expression in leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051038)
2004
29
Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). (15488127)
2004
30
Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal model. (15307213)
2004
31
Epstein-Barr virus-associated smooth muscle tumor of the basal ganglia in an HIV+ child: case report and review of the literature. (15022062)
2004
32
Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumors and endometrial stromal sarcoma. (14576480)
2003
33
Intratumoral fasciitis-like change in a gastric smooth muscle tumor after fine-needle aspiration. (11447746)
2001
34
Intraplacental smooth muscle tumor. A case report. (11725743)
2001
35
Esophageal smooth muscle tumor in a 25-year-old woman with congenital malformations. (11686481)
2001
36
Intraplacental smooth muscle tumor: a case report. (11444205)
2001
37
Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors. (11127756)
2000
38
Pathology and pathophysiology of uterine smooth-muscle tumors. (11035982)
2000
39
Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. (10478672)
1999
40
Primary smooth muscle tumor of the liver encasing hepatobiliary cystadenoma without mesenchymal stroma. (10403311)
1999
41
Endoscopic features of intestinal smooth muscle tumor in a child with AIDS. (10235596)
1999
42
Galectin fingerprinting in tumor diagnosis. Differential expression of galectin-3 and galectin-3 binding sites, but not galectin-1, in benign vs malignant uterine smooth muscle tumors. (10230352)
1999
43
Expression of nm23 in gastrointestinal smooth muscle tumors and its relation to cell proliferative activity]. (11825432)
1998
44
Catamenial fevers associated with a uterine smooth muscle tumor of undetermined malignant potential. (9764658)
1998
45
An avaII restriction fragment length polymorphism in the insulin-like growth factor II gene and the occurrence of smooth muscle tumors. (7902208)
1993
46
Expression and CpG methylation of the insulin-like growth factor II gene in human smooth muscle tumors. (1358435)
1992
47
Uterine benign-appearing smooth muscle tumor "metastatic" to the lungs: a case report. (2256201)
1990
48
Characteristics of an adenylate cyclase coupled beta 2-adrenergic receptor in a smooth muscle tumor cell line. (6323709)
1983
49
Myxoid variant of epithelioid smooth muscle tumor. (7416086)
1980
50
Vitamin B12 deficiency and lack of intrinsic factor associated with a smooth muscle tumor of the stomach. Remission after surgery. (4436038)
1974

Variations for Smooth Muscle Tumor

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Expression for genes affiliated with Smooth Muscle Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for genes affiliated with Smooth Muscle Tumor

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5ACTC1, DES

Compounds for genes affiliated with Smooth Muscle Tumor

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1streptavidin469.9DES, CR2
2orcein469.9ACTC1, DES
3s 100469.8ACTC1, DES
4reticulin469.8ACTC1, DES
5mucicarmine469.8ACTC1, DES
6b 723469.8ACTC1, DES
7ccl446 3010.8DES, CCL11
8hematoxylin469.5CR2, ACTC1, DES
9hmga469.5HMGA2, CCNA2
10procollagen469.5DES, ACTC1
11progestin469.3NME1, DES
12actinomycin d469.3DES, CCL11, HMGA2
13biotin46 25 1211.2NME1, ACTC1, DES
14matrigel469.2CCL11, ACTC1, NME1
15adpribose469.2CCNA2, DES
16creatinine469.0DES, ACTC1, NME1
17doxorubicin46 52 1210.9HMGA2, CCNA2, DES
18glycogen46 259.9ACTC1, CCNA2, DES
19cyclosporin a46 30 6210.7CCNA2, CCL11, ACTC1, CR2
20threonine468.7CR2, CCL11, CCNA2, DES
21cisplatin46 52 62 1211.7HMGA2, NME1, CCNA2
22oxygen46 259.5ACTC1, CCL11, CCNA2, DES
23thymidine46 259.5DES, CCNA2, CCL11, NME1
24nitric oxide46 25 1210.5DES, CCNA2, CCL11, NME1
25dexamethasone46 52 30 1211.4CCNA2, CCL11, ACTC1, NME1
26progesterone46 30 62 25 1212.4DES, CCNA2, ACTC1, NME1
27testosterone46 62 25 1211.4ACTC1, CCNA2, DES
28serine468.3NME1, CR2, CCNA2, DES
29estrogen468.1DES, CCNA2, ACTC1, CR2, NME1
30steroid468.0DES, CCNA2, CCL11, ACTC1, NME1
31vegf468.0DES, CCNA2, CCL11, ACTC1, NME1
32tyrosine467.7DES, CCNA2, CCL11, ACTC1, CR2, NME1
33calcium46 52 25 1210.7DES, CCNA2, CCL11, ACTC1, CR2, NME1
34paraffin467.6HMGA2, NME1, CR2, ACTC1, CCNA2, DES
35retinoic acid46 258.5DES, CCNA2, CCL11, ACTC1, NME1, HMGA2

GO Terms for genes affiliated with Smooth Muscle Tumor

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17Gene Ontology
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Biological processes related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:0096159.5HMGA2, CCL11
2muscle filament slidingGO:0300499.4ACTC1, DES
3cytoskeleton organizationGO:0070109.3CCL11, DES
4mitotic G2 DNA damage checkpointGO:0070959.1HMGA2, CCNA2

Products for genes affiliated with Smooth Muscle Tumor

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  • Antibodies
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Sources for Smooth Muscle Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet