MCID: SMT002
MIFTS: 37

Smooth Muscle Tumor malady

Cancer diseases category

Aliases & Classifications for Smooth Muscle Tumor

About this section
Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt
See all sources

Smooth Muscle Tumor, Aliases & Descriptions:

Name: Smooth Muscle Tumor 9 11 43 60
Smooth Muscle Tumour of Uncertain Malignant Potential 9
 
Neoplasm of the Smooth Muscle 9
Smooth Muscle Tumor Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4310
MeSH33 D018235
SNOMED-CT55 75109009, 189799007
NCIt38 C3751

Summaries for Smooth Muscle Tumor

About this section


MalaCards based summary: Smooth Muscle Tumor, also known as smooth muscle tumour of uncertain malignant potential, is related to endometrial stromal sarcoma and leiomyosarcoma. An important gene associated with Smooth Muscle Tumor is CR2 (complement component (3d/Epstein Barr virus) receptor 2), and among its related pathways is Striated Muscle Contraction. The compounds streptavidin and orcein have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and liver, and related mouse phenotype homeostasis/metabolism.

Related Diseases for Smooth Muscle Tumor

About this section

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1endometrial stromal sarcoma31.1ACTC1, DES
2leiomyosarcoma30.8CCL11, ACTC1, CR2, DES
3fasciitis30.8ACTC1
4adenosarcoma30.5ACTC1, DES
5gastrointestinal stromal tumor30.4ACTC1, DES
6leiomyoma30.4HMGA2, CR2, ACTC1, DES, CCL11
7sarcoma30.1ACTC1, CR2, HMGA2, DES, CCNA2
8b-cell lymphomas30.0HMGA2, CCNA2, CR2
9breast cancer29.7CCNA2, ACTC1, NME1
10adenocarcinoma29.5NME1, ACTC1, HMGA2, CCNA2
11leukemia29.4CCNA2, CR2, NME1, HMGA2, CCL11
12mixed endometrial stromal and smooth muscle tumor10.5
13infantile myofibromatosis10.5DES
14lipomatosis10.4HMGA2
15pleomorphic adenoma10.4HMGA2
16hepatitis10.3
17acquired immunodeficiency syndrome10.3
18intravenous leiomyomatosis10.3
19esophagitis10.3
20epithelioid leiomyosarcoma10.2ACTC1, DES
21pseudosarcomatous fibromatosis10.2ACTC1, DES
22dedifferentiated liposarcoma10.2HMGA2, DES
23spindle cell carcinoma10.2ACTC1, DES
24spindle cell sarcoma10.2ACTC1, DES
25desmoid disease, hereditary10.2DES, ACTC1
26cutaneous fibrous histiocytoma10.2ACTC1, DES
27fibrous histiocytoma10.2ACTC1, DES
28dermatofibrosarcoma protuberans10.2ACTC1, DES
29rhabdoid tumor10.2ACTC1, DES
30hemangiopericytoma10.2ACTC1, DES
31angiomyolipoma10.2DES, ACTC1
32malignant mixed mullerian tumor10.2ACTC1, DES
33embryonal rhabdomyosarcoma10.2ACTC1, DES
34glomus tumor10.2ACTC1, DES
35fibroma10.2ACTC1, DES
36fibromatosis10.2DES, ACTC1
37lipoma10.2HMGA2, DES
38giant cell tumor10.2DES, ACTC1
39abrikosov's tumor10.2DES, ACTC1
40liposarcoma10.2DES, HMGA2
41sarcoma, synovial10.2HMGA2, DES
42uterine fibroid10.2DES, HMGA2
43neurilemmoma10.2DES, ACTC1
44mesothelioma10.1DES, ACTC1
45lymphangioleiomyomatosis10.1
46glucocorticoid resistance10.1
47alport syndrome10.1
48common variable immunodeficiency10.1
49diffuse large b-cell lymphoma10.1
50cystadenoma10.1

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to smooth muscle tumor

Symptoms for Smooth Muscle Tumor

About this section

Drugs & Therapeutics for Smooth Muscle Tumor

About this section

Drug clinical trials:

Search ClinicalTrials for Smooth Muscle Tumor

Search NIH Clinical Center for Smooth Muscle Tumor

Genetic Tests for Smooth Muscle Tumor

About this section

Anatomical Context for Smooth Muscle Tumor

About this section

MalaCards organs/tissues related to Smooth Muscle Tumor:

31
Smooth muscle, Uterus, Liver, Lung, Bone, Spleen, Heart, Breast, Skin, Ovary, Placenta, Prostate, Tonsil, B cells, Endothelial

Animal Models for Smooth Muscle Tumor or affiliated genes

About this section

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0HMGA2, NME1, CR2, ACTC1, DES

Publications for Smooth Muscle Tumor

About this section

Articles related to Smooth Muscle Tumor:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. (24196187)
2014
2
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. (25272296)
2014
3
The measurement of stiffness of uterine smooth muscle tumor by elastography. (25019043)
2014
4
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. (24062958)
2013
5
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. (24319862)
2013
6
Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. (23517922)
2013
7
Completely infarcted smooth muscle tumor of the placental membrane. (23279350)
2013
8
Periurethral smooth muscle tumor of undetermined malignant potential. (22720177)
2012
9
Epstein-Barr virus-associated smooth muscle tumor of the tonsil. (21885224)
2012
10
Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. (22217299)
2012
11
Multifocal vulvar smooth muscle tumor with an unusual intravascular growth pattern and multiple local recurrences in a 10-year-old child: a diagnostic dilemma. (21090988)
2011
12
Epstein-Barr Virus-Associated Adrenal Smooth Muscle Tumors and Disseminated Diffuse Large B-Cell Lymphoma in a Child With Common Variable Immunodeficiency: A Case Report and Review of the Literature. (21454372)
2011
13
Retroperitoneal smooth muscle tumor of uncertain malignant potential after hysterectomy: a case report. (21619667)
2011
14
"Low-grade leiomyosarcoma" and late-recurring smooth muscle tumors of the uterus: a heterogenous collection of frequently misdiagnosed tumors associated with an overall favorable prognosis relative to conventional uterine leiomyosarcomas. (21921786)
2011
15
Rapid recurrence of uterine smooth muscle tumor of uncertain malignant potential as leiomyosarcoma. (21457977)
2011
16
Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient. (19659510)
2010
17
Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report. (19830174)
2009
18
Uterine smooth muscle tumor of uncertain malignant potential: a three-case report. (17986240)
2008
19
Pseudo-Meigs' syndrome caused by uterine smooth muscle tumor of uncertain malignant potential with low vascular endothelial growth factor expression. (17944915)
2008
20
Multifocal Epstein-Barr virus-associated smooth muscle tumor in adults with AIDS: case report and review of the literature. (18714165)
2008
21
Laryngeal epithelioid smooth muscle tumor of low malignant potential. (17599590)
2007
22
Epstein-Barr virus-associated smooth muscle tumor in patients with acquired immunodeficiency syndrome. (17446968)
2007
23
Endoscopic management of gastrointestinal smooth muscle tumor. (17828822)
2007
24
Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. (17550381)
2007
25
Analysis of allelic loss as an adjuvant tool in evaluation of malignancy in uterine smooth muscle tumors. (16330948)
2006
26
Primary smooth muscle tumor of the pleura: a clinicopathological case report with ultrastructural observations and a review of the literature. (16257865)
2005
27
Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors. (15377824)
2005
28
A 40-year-old woman with multiple uterine masses. Stromomyoma--mixed endometrial stromal-smooth muscle tumor of the uterus. (16329742)
2005
29
Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051039)
2004
30
Expression of matrix metalloproteinases in patients with uterine smooth muscle tumors: an immunohistochemical analysis of MMP-1 and MMP-2 protein expression in leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. (15051038)
2004
31
Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). (15488127)
2004
32
Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal model. (15307213)
2004
33
Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumors and endometrial stromal sarcoma. (14576480)
2003
34
Intratumoral fasciitis-like change in a gastric smooth muscle tumor after fine-needle aspiration. (11447746)
2001
35
Intraplacental smooth muscle tumor. A case report. (11725743)
2001
36
Esophageal smooth muscle tumor in a 25-year-old woman with congenital malformations. (11686481)
2001
37
Intraplacental smooth muscle tumor: a case report. (11444205)
2001
38
Analysis of KIT mutation and protein expression in fine needle aspirates of gastrointestinal stromal/smooth muscle tumors. (11127756)
2000
39
Pathology and pathophysiology of uterine smooth-muscle tumors. (11035982)
2000
40
Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. (10478672)
1999
41
Primary smooth muscle tumor of the liver encasing hepatobiliary cystadenoma without mesenchymal stroma. (10403311)
1999
42
Endoscopic features of intestinal smooth muscle tumor in a child with AIDS. (10235596)
1999
43
Expression of nm23 in gastrointestinal smooth muscle tumors and its relation to cell proliferative activity]. (11825432)
1998
44
Catamenial fevers associated with a uterine smooth muscle tumor of undetermined malignant potential. (9764658)
1998
45
An avaII restriction fragment length polymorphism in the insulin-like growth factor II gene and the occurrence of smooth muscle tumors. (7902208)
1993
46
Expression and CpG methylation of the insulin-like growth factor II gene in human smooth muscle tumors. (1358435)
1992
47
Uterine benign-appearing smooth muscle tumor "metastatic" to the lungs: a case report. (2256201)
1990
48
Characteristics of an adenylate cyclase coupled beta 2-adrenergic receptor in a smooth muscle tumor cell line. (6323709)
1983
49
Myxoid variant of epithelioid smooth muscle tumor. (7416086)
1980
50
Vitamin B12 deficiency and lack of intrinsic factor associated with a smooth muscle tumor of the stomach. Remission after surgery. (4436038)
1974

Variations for Smooth Muscle Tumor

About this section

Expression for genes affiliated with Smooth Muscle Tumor

About this section
Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for genes affiliated with Smooth Muscle Tumor

About this section

Pathways related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5ACTC1, DES

Compounds for genes affiliated with Smooth Muscle Tumor

About this section

Compounds related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1streptavidin439.9DES, CR2
2orcein439.9ACTC1, DES
3s 100439.8ACTC1, DES
4reticulin439.8ACTC1, DES
5mucicarmine439.8ACTC1, DES
6b 723439.8ACTC1, DES
7ccl443 2810.8DES, CCL11
8hematoxylin439.5CR2, ACTC1, DES
9hmga439.5HMGA2, CCNA2
10procollagen439.5DES, ACTC1
11progestin439.3NME1, DES
12actinomycin d439.3DES, CCL11, HMGA2
13biotin43 24 1211.2NME1, ACTC1, DES
14matrigel439.2CCL11, ACTC1, NME1
15adpribose439.2CCNA2, DES
16creatinine439.0DES, ACTC1, NME1
17doxorubicin43 49 1210.9HMGA2, CCNA2, DES
18glycogen43 249.9ACTC1, CCNA2, DES
19cyclosporin a43 28 5910.7CCNA2, CCL11, ACTC1, CR2
20threonine438.7CR2, CCL11, CCNA2, DES
21cisplatin43 49 59 1211.7HMGA2, NME1, CCNA2
22oxygen43 249.5ACTC1, CCL11, CCNA2, DES
23thymidine43 249.5DES, CCNA2, CCL11, NME1
24nitric oxide43 24 1210.5DES, CCNA2, CCL11, NME1
25dexamethasone43 49 28 1211.4CCNA2, CCL11, ACTC1, NME1
26progesterone43 28 59 24 1212.4DES, CCNA2, ACTC1, NME1
27testosterone43 59 24 1211.4ACTC1, CCNA2, DES
28serine438.3NME1, CR2, CCNA2, DES
29estrogen438.1DES, CCNA2, ACTC1, CR2, NME1
30steroid438.0DES, CCNA2, CCL11, ACTC1, NME1
31vegf438.0DES, CCNA2, CCL11, ACTC1, NME1
32tyrosine437.7DES, CCNA2, CCL11, ACTC1, CR2, NME1
33calcium43 49 24 1210.7DES, CCNA2, CCL11, ACTC1, CR2, NME1
34paraffin437.6HMGA2, NME1, CR2, ACTC1, CCNA2, DES
35retinoic acid43 248.5DES, CCNA2, CCL11, ACTC1, NME1, HMGA2

GO Terms for genes affiliated with Smooth Muscle Tumor

About this section

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00096159.5HMGA2, CCL11
2muscle filament slidingGO:00300499.4ACTC1, DES
3cytoskeleton organizationGO:00070109.3CCL11, DES
4mitotic G2 DNA damage checkpointGO:00070959.1HMGA2, CCNA2

Products for genes affiliated with Smooth Muscle Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Smooth Muscle Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet