MCID: SMT002
MIFTS: 37

Smooth Muscle Tumor

Categories: Cancer diseases

Aliases & Classifications for Smooth Muscle Tumor

MalaCards integrated aliases for Smooth Muscle Tumor:

Name: Smooth Muscle Tumor 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4310
MeSH 42 D018235
NCIt 47 C3751
SNOMED-CT 64 189799007 75109009
UMLS 69 C0206658

Summaries for Smooth Muscle Tumor

MalaCards based summary : Smooth Muscle Tumor is related to gastrointestinal stromal tumor and adenosarcoma. An important gene associated with Smooth Muscle Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways is Striated Muscle Contraction. The drugs Desflurane and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and bone, and related phenotypes are cellular and hematopoietic system

Related Diseases for Smooth Muscle Tumor

Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
id Related Disease Score Top Affiliating Genes
1 gastrointestinal stromal tumor 28.4 ACTC1 DES KIT VIM
2 adenosarcoma 28.0 ACTC1 DES KIT PGR VIM
3 mixed endometrial stromal and smooth muscle tumor 12.2
4 intravenous leiomyomatosis 11.3
5 leiomyosarcoma 11.2
6 leiomyoma 11.2
7 leiomyomatosis 11.1
8 uterine fibroid 10.8
9 rectum leiomyosarcoma 10.8
10 pyoderma 10.7 PGR VIM
11 rhabditida infections 10.7 CCL11 VIM
12 thyroid angiosarcoma 10.6 KIT PGR
13 colon neuroendocrine neoplasm 10.6 KIT PGR
14 pseudomyxoma peritonei 10.6 KIT VIM
15 spiradenoma 10.6 KIT PGR
16 diffuse meningeal melanocytosis 10.6 KIT VIM
17 extragonadal nonseminomatous germ cell tumor 10.6 KIT PGR
18 alcohol-induced mental disorder 10.6 KIT VIM
19 female urethral cancer 10.6 CCL11 CCR3
20 influenza 10.6 CCL11 CCR3
21 malignant breast melanoma 10.6 KIT VIM
22 infantile scoliosis 10.5 DES VIM
23 prostate disease 10.5 KIT VIM
24 intellectual disability-polydactyly-uncombable hair syndrome 10.5 DES VIM
25 kidney benign neoplasm 10.5 PGR VIM
26 kidney lipoma 10.5 HMGA2 PGR
27 cellular ependymoma 10.5 DES VIM
28 nasal cavity squamous cell carcinoma 10.5 KIT PGR
29 bartholin's gland benign neoplasm 10.5 ESR1 PGR
30 small intestine neuroendocrine neoplasm 10.5 DES VIM
31 central nervous system organ benign neoplasm 10.5 ESR1 PGR
32 gallbladder leiomyoma 10.5 ESR1 PGR
33 lung adenoma 10.5 ESR1 PGR
34 glaucoma, hereditary 10.5 ESR1 PGR
35 space motion sickness 10.5 DES VIM
36 fallopian tube benign neoplasm 10.5 ESR1 PGR
37 childhood pleomorphic rhabdomyosarcoma 10.5 DES VIM
38 paranasal sinus disease 10.5 ESR1 PGR
39 dartoic leiomyoma 10.5 ESR1 PGR
40 urinary bladder inverted papilloma 10.5 ESR1 PGR
41 encephalitozoonosis 10.5 HMGA2 KIT
42 spinal cancer 10.5 ESR1 PGR
43 subglottis verrucous carcinoma 10.4 ESR1 PGR
44 deafness, autosomal dominant 8/12 10.4 ESR1 PGR
45 testis rhabdomyosarcoma 10.4 DES KIT
46 intestinal perforation 10.4 ESR1 PGR
47 gastric tubular adenocarcinoma 10.4 ESR1 PGR
48 her2-receptor positive breast cancer 10.4 ESR1 PGR
49 sarcomatoid squamous cell skin carcinoma 10.4 ESR1 PGR
50 extraskeletal mesenchymal chondrosarcoma 10.4 DES VIM

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to Smooth Muscle Tumor

Symptoms & Phenotypes for Smooth Muscle Tumor

MGI Mouse Phenotypes related to Smooth Muscle Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 ACTC1 CCR3 DES ESR1 KIT PGR
2 hematopoietic system MP:0005397 9.87 CCL11 CCR3 CR2 ESR1 KIT PGR
3 homeostasis/metabolism MP:0005376 9.86 ACTC1 CCR3 CR2 DES ESR1 KIT
4 immune system MP:0005387 9.7 CCL11 CCR3 CR2 ESR1 KIT PGR
5 muscle MP:0005369 9.43 ACTC1 DES ESR1 KIT PGR VIM
6 respiratory system MP:0005388 9.02 CCL11 CCR3 ESR1 KIT VIM

Drugs & Therapeutics for Smooth Muscle Tumor

Drugs for Smooth Muscle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desflurane Approved Phase 4 57041-67-5 42113
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Remifentanil Approved Phase 4 132875-61-7 60815
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5
Nitric Oxide Approved Phase 4 10102-43-9 145068
6 Neurotransmitter Agents Phase 4,Phase 2
7 Peripheral Nervous System Agents Phase 4,Phase 2
8 Anti-Infective Agents Phase 4,Phase 2,Phase 1
9 Antiviral Agents Phase 4,Phase 2,Phase 1
10 Analgesics Phase 4,Phase 2
11 Anesthetics Phase 4,Phase 2
12 Anesthetics, General Phase 4,Phase 2
13 Anesthetics, Intravenous Phase 4,Phase 2
14 Central Nervous System Depressants Phase 4,Phase 2
15 Autonomic Agents Phase 4,Phase 2
16 Anesthetics, Dissociative Phase 4
17 Excitatory Amino Acid Antagonists Phase 4
18 Excitatory Amino Acids Phase 4
19 Vasodilator Agents Phase 4,Phase 2
20 Anti-Asthmatic Agents Phase 4
21 Antidotes Phase 4
22 Antioxidants Phase 4
23 Bronchodilator Agents Phase 4
24 Endothelium-Dependent Relaxing Factors Phase 4
25 Expectorants Phase 4
26 N-monoacetylcystine Phase 4
27 Protective Agents Phase 4
28 Respiratory System Agents Phase 4
29 arginine Nutraceutical Phase 4
30
Simvastatin Approved Phase 3 79902-63-9 54454
31 Papaya Approved, Nutraceutical Phase 2, Phase 3
32 Antimetabolites Phase 3,Phase 2,Phase 1
33 Anticholesteremic Agents Phase 3
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
35 Hypolipidemic Agents Phase 3
36 Lipid Regulating Agents Phase 3
37 Tea Nutraceutical Phase 2, Phase 3
38
Acetylcholine Approved Phase 2 51-84-3 187
39
Peginterferon alfa-2b Approved Phase 2 99210-65-8, 215647-85-1
40
Prazosin Approved Phase 2 19216-56-9 4893
41
Ribavirin Approved Phase 2 36791-04-5 37542
42
Diazepam Approved, Illicit, Vet_approved Phase 2 439-14-5 3016
43
Ibuprofen Approved Phase 2 15687-27-1 3672
44
Nintedanib Approved Phase 2 656247-17-5 56843413
45
Trimetazidine Approved Phase 2 5011-34-7
46
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
47
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
48
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
49 abobotulinumtoxinA Phase 2
50 Botulinum Toxins Phase 2

Interventional clinical trials:

(show all 22)

id Name Status NCT ID Phase Drugs
1 Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation Recruiting NCT02962999 Phase 4 Ketamine;Saline
2 N-Acetylcysteine and Arginine Administration in Diabetic Patients Terminated NCT00569465 Phase 4 Arginine;Acetylcysteine;Placebo
3 Molecular and Clinical Effects of Green Tea and Fermented Papaya Preparation on Diabetes and Cardiovascular Diseases Completed NCT01248143 Phase 2, Phase 3
4 The Effect of Simvastatin on Uterine Leiomyoma Development and Growth in Infertile Women Recruiting NCT03134157 Phase 3 oral drug and vaginal placebo;oral drug and oral placebo;Vaginal placebo+ oral placebo
5 The Value of Botox-A for Management of Low Anterior Resection Syndrome Unknown status NCT01589471 Phase 2 intra-rectal Botulinum toxin A injection
6 Efficacy of Prazosin Versus Placebo Associated With Peg-Interferon Alpha 2b and Ribavirin in Chronic Hepatitis C With Genotype 1 or 4 and Severe Fibrosis Unknown status NCT00148837 Phase 2 Peg-interferon alpha 2b (drug);Ribavirin (drug);Prazosin (drug)
7 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
8 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
9 Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect Completed NCT00121563 Phase 2 Thalidomide, Ibuprofen or Diazepam
10 Nintedanib(BIBF1120) in Thyroid Cancer Recruiting NCT01788982 Phase 2 Nintedanib;Placebo
11 Trimetazidine in Pulmonary Artery Hypertension Recruiting NCT02102672 Phase 2 Trimetazidine
12 Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma Not yet recruiting NCT03123276 Phase 1, Phase 2 Pembrolizumab;Gemcitabine
13 Clinical Trial Of Neoadjuvant Chemotherapy (NAC)In Upper Tract Urothelial Carcinoma (UTUC) Terminated NCT01663285 Phase 2 Neoadjuvant Cisplatin and Gemcitabine
14 Can Fat Derived Stem Cells (SVF) be Used in the Treatment of Erectile Dysfunction After Prostatectomy Unknown status NCT02240823 Phase 1
15 Investigation of the Suburothelial Myofibroblast Network and of Smooth Muscle Function and Control in the Human Urinary Outflow Tract Unknown status NCT01227447
16 Correlation Between Vitamin D Levels to ADAMTS13 , VWF and Micro RNA Expression in Diabetic Hemodialysis Patients Unknown status NCT02245633
17 Surgery for Intravenous Leiomyomatosis Completed NCT01707862
18 Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer Recruiting NCT00050752
19 Mitochondrial and Microbiota Relationship Recruiting NCT03213067
20 WISE CVD - Continuation (WISE HFpEF) Recruiting NCT02582021
21 Comparison of Safety and Efficacy of Detaenial Sigmoid Neobladder and Ileal Neobladder Enrolling by invitation NCT03108196
22 Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study Not yet recruiting NCT02873182

Search NIH Clinical Center for Smooth Muscle Tumor

Cochrane evidence based reviews: smooth muscle tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

MalaCards organs/tissues related to Smooth Muscle Tumor:

39
Smooth Muscle, Uterus, Bone, Lung, Bone Marrow, Thyroid, Liver

Publications for Smooth Muscle Tumor

Articles related to Smooth Muscle Tumor:

(show top 50) (show all 178)
id Title Authors Year
1
Potential role of BCL2 in the recurrence of uterine smooth muscle tumors of uncertain malignant potential. ( 28004108 )
2017
2
Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver. ( 28756985 )
2017
3
Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis. ( 28340268 )
2017
4
Resolution of Multifocal Epstein-Barr Virus-Related Smooth Muscle Tumor in a Patient with GATA2 Deficiency Following Hematopoietic Stem Cell Transplantation. ( 27924436 )
2017
5
Proposed novel nomenclature of vulvar smooth muscle tumors; a case of Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) of the vulva. ( 28180147 )
2017
6
Epstein-Barr virus-associated smooth muscle tumor as the initial presentation of HIV infection: A case report. ( 28532583 )
2017
7
Primary inferior vena cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum. ( 28623706 )
2017
8
EBV-associated hepatic smooth muscle tumor of uncertain biologic behavior after heart transplantation in a pediatric patient: case report. ( 28280632 )
2017
9
Ellipsoid Smooth Muscle Tumor of the Lower Eyelid: An Exploration of Its Possible Origin. ( 28700399 )
2017
10
PET/CT in an 8-Year-Old Girl With Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 28806251 )
2017
11
Morcellator's Port-site Metastasis of a Uterine Smooth Muscle Tumor of Uncertain Malignant Potential After Minimally Invasive Myomectomy. ( 26851127 )
2016
12
Primary Intraosseous Smooth Muscle Tumor of Uncertain Malignant Potential: Original Report and Molecular Characterization. ( 27994831 )
2016
13
EMMPRIN (CD147) Expression in Smooth Muscle Tumors of the Uterus. ( 26352545 )
2016
14
Smooth Muscle Tumor Originating in the Pleura: A Case Report and Updated Literature Review. ( 27747117 )
2016
15
Epstein-Barr virus-associated iris smooth muscle tumor with epithelioid morphology in AIDS patients: a case report. ( 27099533 )
2016
16
Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors. ( 26892441 )
2016
17
Successful pregnancy following myomectomy for uterine smooth muscle tumor of uncertain malignant potential: A case report and review of the literature. ( 26937476 )
2016
18
A clinicopathological study of atypical leiomyomas: Benign variant leiomyoma or smooth-muscle tumor of uncertain malignant potential. ( 26893755 )
2016
19
Dome-shaped metastatic lesion on the scalp from a uterine smooth muscle tumor of uncertain malignant potential (STUMP). ( 27086706 )
2016
20
Lacrimal Sac Smooth Muscle Tumor of Uncertain Malignant Potential. ( 27306954 )
2016
21
Rare Presentations of Epstein-Barr Virus--Associated Smooth Muscle Tumor in Children. ( 26230054 )
2016
22
Epstein-Barr virus-associated smooth muscle tumor of the cavernous sinus: a delayed complication of allogenic peripheral blood stem cell transplantation: case report. ( 27341041 )
2016
23
The role of fibroblast growth factor 2 in patients with uterine smooth muscle tumors: an immunohistochemical study. ( 27825029 )
2016
24
Epstein-Barr Virus-Associated Smooth Muscle Tumor. ( 27362573 )
2016
25
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. ( 26045786 )
2015
26
Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma / smooth muscle tumor with uncertain malignant potential and benign leiomyoma. ( 26383110 )
2015
27
High 18F-FDG uptake for uterine smooth muscle tumor of uncertain malignant potential. ( 25674868 )
2015
28
Two-stage resection of a disseminated mixed endometrial stromal sarcoma and smooth muscle tumor with intravascular and intracardiac extension. ( 26701002 )
2015
29
Mixed endometrial stromal and smooth muscle tumor with heart metastasis: report of a case and review of literature. ( 25755804 )
2015
30
Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant. ( 25698060 )
2015
31
Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors. ( 26472283 )
2015
32
Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma. ( 26960523 )
2015
33
Effects of Morcellation of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential and Endometrial Stromal Sarcoma: Case Series and Recommendations for Clinical Practice. ( 25596464 )
2015
34
Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions. ( 25932961 )
2015
35
Epstein-Barr Virus-Associated Pulmonary Smooth Muscle Tumor After Lung Transplantation. ( 26046906 )
2015
36
Expression of B23/Nucleophosphamine Nonribosomal Nucleolar Protein in Smooth Muscle Tumors of the Corpus Uteri. ( 26642792 )
2015
37
CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma. ( 25509988 )
2014
38
MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. ( 24196187 )
2014
39
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
40
The measurement of stiffness of uterine smooth muscle tumor by elastography. ( 25019043 )
2014
41
Primary mesenteric smooth muscle tumor: an entity with unpredictable biologic behavior. ( 24062958 )
2013
42
Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells. ( 23022018 )
2013
43
Smooth muscle tumor of uncertain malignant potential of the urinary bladder: a case report and review of the literature. ( 23810438 )
2013
44
Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. ( 23517922 )
2013
45
Completely infarcted smooth muscle tumor of the placental membrane. ( 23279350 )
2013
46
MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. ( 23225304 )
2013
47
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. ( 24319862 )
2013
48
Extrauterine mixed endometrial stromal-smooth muscle tumor: Report of an unusual entity. ( 24455616 )
2013
49
Multifocal Histologically Malignant Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Pediatric Transplant Patient With an Indolent Course. ( 23842005 )
2013
50
Atypical smooth muscle tumor of the vagina--a pediatric case report and review of the literature. ( 23701791 )
2013

Variations for Smooth Muscle Tumor

Expression for Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for Smooth Muscle Tumor

Pathways related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.66 ACTC1 DES VIM

GO Terms for Smooth Muscle Tumor

Biological processes related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.8 CCL11 CCR3 CR2 ESR1 HMGA2 KIT
2 positive regulation of gene expression GO:0010628 9.71 ACTC1 HMGA2 KIT VIM
3 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.54 ESR1 HMGA2 KIT
4 response to radiation GO:0009314 9.46 CCL11 KIT
5 intermediate filament organization GO:0045109 9.43 DES VIM
6 positive regulation of phospholipase C activity GO:0010863 9.32 ESR1 KIT
7 mast cell chemotaxis GO:0002551 9.16 CCL11 KIT
8 muscle filament sliding GO:0030049 9.13 ACTC1 DES VIM
9 stem cell differentiation GO:0048863 8.8 ESR1 HMGA2 KIT

Molecular functions related to Smooth Muscle Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Smooth Muscle Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....