MCID: SMT002
MIFTS: 50

Smooth Muscle Tumor malady

Cancer category

Summaries for Smooth Muscle Tumor

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33MalaCards
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MalaCards: Smooth Muscle Tumor, also known as smooth muscle tumour of uncertain malignant potential, is related to endometrial stromal sarcoma and gastrointestinal stromal tumor. An important gene associated with Smooth Muscle Tumor is DES (desmin), and among its related pathways are Advanced glycosylation endproduct receptor signaling and G2 Phase. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include spleen, smooth muscle and small intestine, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Smooth Muscle Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

smooth muscle tumor 8 10 45 61
smooth muscle tumour of uncertain malignant potential 8
neoplasm of the smooth muscle 8
smooth muscle tumor nos 8


External Ids:

Disease Ontology8 DOID:4310
NCIt40 C3751
SNOMED-CT57 75109009, 189799007
MeSH35 D018235

Related Diseases for Smooth Muscle Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Smooth Muscle Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1endometrial stromal sarcoma30.7ACTC1, KIT, MME, PGR, DES, VIM
2gastrointestinal stromal tumor30.5ACTC1, KIT, PCNA, MKI67, DES, S100A1
3uterine sarcoma30.4KIT, MME, DES
4cystadenoma30.1MME
5lymphangioleiomyomatosis30.1PGR, DES
6uterine fibroid30.1HMGA2, PGR
7b-cell lymphomas30.1HMGA2, MME, CDK2, MKI67, CR2, IFI27
8adenocarcinoma30.1LGALS3, ACTC1, HMGA2, NME1, MME, PGR
9mixed endometrial stromal and smooth muscle tumor10.3
10intravenous leiomyomatosis10.3
11acquired immunodeficiency syndrome10.3
12uterus leiomyosarcoma10.3
13alport syndrome10.1
14esophagus leiomyoma10.1
15perivascular epithelioid cell tumor10.1
16clear cell adenocarcinoma10.1
17common variable immunodeficiency10.1
18factor v deficiency10.1
19larynx leiomyosarcoma10.1
20conventional leiomyosarcoma10.1
21uterus perivascular epithelioid cell tumor10.1
22diffuse large b-cell lymphoma10.1
23intrinsic factor deficiency10.1
24mass syndrome10.1
25lymphoma, diffuse large cell10.1
26pseudo-meigs syndrome10.1
27meigs syndrome10.1
28esophagitis10.0CCL11
29uterine carcinosarcoma10.0KIT
30germ cell tumors10.0KIT
31ductal carcinoma in situ10.0PGR
32hepatitis10.0CCL11
33sinusitis10.0CCL11
34neuroblastoma10.0NME1
35li-fraumeni syndrome10.0PGR
36hemangioma10.0ACTC1
37infantile myofibromatosis10.0DES
38histiocytosis10.0S100B
39hemangioblastoma10.0S100B
40thymic carcinoma10.0KIT
41leiomyomatosis10.0PGR
42skin melanoma10.0NME1
43renal oncocytoma10.0S100A1
44fasciitis10.0ACTC1
45myofibroma10.0CALD1
46nephrotic syndrome10.0CCL11
47endometrial stromal nodule10.0CALD1
48carney triad10.0KIT
49teratoma10.0ACTC1, KIT
50atopic dermatitis10.0CCL11

Graphical network of the top 20 diseases related to Smooth Muscle Tumor:



Diseases related to smooth muscle tumor

Clinical Features for Smooth Muscle Tumor

Drugs & Therapeutics for Smooth Muscle Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Smooth Muscle Tumor

Drug clinical trials:

Search ClinicalTrials for Smooth Muscle Tumor

Search NIH Clinical Center for Smooth Muscle Tumor

Search CenterWatch for Smooth Muscle Tumor

Genetic Tests for Smooth Muscle Tumor

Anatomical Context for Smooth Muscle Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Smooth Muscle Tumor:

33
Spleen, Smooth muscle, Small intestine, Colon, Kidney, Liver, Lung, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Uterus, Placenta, Prostate, Tonsil, Monocytes, B cells, Endothelial, Pituitary, Uterus corpus

Animal Models for Smooth Muscle Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Smooth Muscle Tumor

Sources:
51PubMed
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Articles related to Smooth Muscle Tumor:

(show top 50)    (show all 253)
idTitleAuthorsYear
1
Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. (24319862)
2013
2
Epstein-Barr virus-associated smooth muscle tumor of the tonsil. (21885224)
2012
3
Epithelioid clear cell smooth muscle tumor of the ovary presenting as a mural nodule in an endometrioid adenocarcinoma with clear cell changes. (21131832)
2011
4
Patterns of bone morphogenetic protein-2 expression in smooth muscle tumors of the uterine corpus and other uterine tissues. (21285872)
2011
5
Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. (20690046)
2010
6
Tumor cells expressing tissue factor influence the migration of smooth muscle cells in a catalytic activity-dependent way. (19794520)
2009
7
Smooth-muscle tumor of the parapharyngeal space. (19224475)
2009
8
The Use of p16 in enhancing the histologic classification of uterine smooth muscle tumors. (18162776)
2008
9
Images in HIV/AIDS. Epstein-Barr virus-associated smooth muscle tumor in a person with AIDS. (18240453)
2008
10
Laryngeal epithelioid smooth muscle tumor of low malignant potential. (17599590)
2007
11
Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. (17550381)
2007
12
Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha. (16407046)
2006
13
Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. (17095724)
2006
14
Single-stage resection of a mixed endometrial stromal sarcoma and smooth muscle tumor with intracardiac and pulmonary extension. (16996971)
2006
15
Primary smooth muscle tumor of the pleura: a clinicopathological case report with ultrastructural observations and a review of the literature. (16257865)
2005
16
Anterior orbital leiomyoma: possible pulley smooth muscle tissue tumor. (16286632)
2005
17
A 40-year-old woman with multiple uterine masses. Stromomyoma--mixed endometrial stromal-smooth muscle tumor of the uterus. (16329742)
2005
18
Paradoxical upregulation of tumor suppressor protein p53 in serum-stimulated vascular smooth muscle cells: a novel negative-feedback regulatory mechanism. (12860918)
2003
19
Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta. (14519761)
2003
20
Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumors and endometrial stromal sarcoma. (14576480)
2003
21
Alpha-tocopherol induces expression of connective tissue growth factor and antagonizes tumor necrosis factor-alpha-mediated downregulation in human smooth muscle cells. (12522127)
2003
22
C-kit expression in uterine leiomyosarcomas: an immunocytochemical study of 29 cases of malignant smooth muscle tumors of the uterus. (12678420)
2003
23
Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists. (11919083)
2002
24
Induction of the hyaluronic acid-binding protein, tumor necrosis factor-stimulated gene-6, in cervical smooth muscle cells by tumor necrosis factor-alpha and prostaglandin E(2). (11943733)
2002
25
Intratumoral fasciitis-like change in a gastric smooth muscle tumor after fine-needle aspiration. (11447746)
2001
26
Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors: an immunohistochemical comparison of 34 cases. (11353058)
2001
27
CDK-inhibitors-associated kinase activity: a possible determinant of malignant potential in smooth muscle tumors of the external soft tissue. (11745414)
2001
28
MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors. (11567229)
2001
29
Activation of p55 tumor necrosis factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular adhesion molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells. (10860946)
2000
30
Interleukin-1 beta, tumor necrosis factor-alpha and lipopolysaccharide induce expression of monocyte chemoattractant protein-1 in calf aortic smooth muscle cells. (12845752)
2000
31
Smooth muscle tumor of the pleura. A case report and review of the literature. (11079027)
2000
32
Tumor necrosis factor-alpha enhances mRNA expression and secretion of interleukin-6 in cultured human airway smooth muscle cells. (10873159)
2000
33
HMB-45/melan-A and smooth muscle actin-positive clear-cell epithelioid tumor arising in the ligamentum teres hepatis: additional example of clear cell 'sugar' tumors. (10976706)
2000
34
Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. (10478672)
1999
35
Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal. (9916914)
1999
36
Fibroblast tropoelastin and alpha-smooth-muscle actin expression are repressed by particulate-activated macrophage-derived tumor necrosis factor-alpha in experimental silicosis. (10423400)
1999
37
Expression of nm23 in gastrointestinal smooth muscle tumors and its relation to cell proliferative activity]. (11825432)
1998
38
Catamenial fevers associated with a uterine smooth muscle tumor of undetermined malignant potential. (9764658)
1998
39
Tumor necrosis factor-alpha activates smooth muscle cell migration in culture and is expressed in the balloon-injured rat aorta. (9102167)
1997
40
Epstein-Barr virus (EBV)-associated smooth-muscle tumor arising in a post-transplant patient treated successfully for two PT-EBV-associated large-cell lymphomas. Case report. (8944045)
1996
41
Cystic smooth-muscle tumor of the liver and spleen associated with Epstein-Barr virus after renal transplantation. (8898848)
1996
42
Epstein-Barr virus-associated post-transplant primary smooth muscle tumor of the liver: report of an autopsy case. (8893230)
1996
43
Gastrointestinal stromal tumor: evidence for a smooth-muscle origin. (7777483)
1995
44
Insulin-like growth factor II in uterine smooth-muscle tumors: maintenance of genomic imprinting in leiomyomata and loss of imprinting in leiomyosarcomata. (7745016)
1995
45
Inhibition of gap junctional intercellular communication between primary human smooth muscle cells by tumor necrosis factor alpha. (7554055)
1995
46
Production of prolactin by smooth muscle cells cultured from human uterine fibroid tumors. (8496322)
1993
47
Tumor necrosis factor alpha potentiates the increase in cytosolic free calcium induced by bradykinin in guinea-pig tracheal smooth muscle cells. (8087627)
1993
48
Uterine benign-appearing smooth muscle tumor "metastatic" to the lungs: a case report. (2256201)
1990
49
Smooth muscle tumor of jejunum. A new mechanism of bleeding. (14462799)
1962
50
Leiomyoma of the esophagus: an unusual smooth muscle tumor. (13901326)
1961

Genetic Variations for Smooth Muscle Tumor

Expression for genes affiliated with Smooth Muscle Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Smooth Muscle Tumor

Search GEO for disease gene expression data for Smooth Muscle Tumor.

Pathways for genes affiliated with Smooth Muscle Tumor

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Smooth Muscle Tumor

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
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Compounds related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8CR2
2cycloheximide4510.7MME
3butyrate4510.6CDK2, CCL11
4orcein4510.4VIM, S100B, DES, ACTC1
5mucicarmine4510.4VIM, S100B, S100A1, DES, ACTC1
6reticulin4510.3VIM, S100B, DES, PCNA, ACTC1
7glycogen45 2411.3IGF2, CCNA2, MKI67, CDK2, KIT, ACTC1
8creatinine4510.3IGF2, CDK2, MME, NME1, ACTC1
9s 1004510.3VIM, S100B, DES, ACTC1
10glutamine4510.3IGF2, CDK2, PCNA, NME1, LGALS3
11tamoxifen45 50 29 1113.3CCNA2, IGF2, MKI67, CDK2, PGR
12b 7234510.3VIM, S100B, S100A1, DES, PCNA, ACTC1
13paclitaxel45 50 1112.3CCNA2, IFI27, S100B, IGF2, CDK2, PGR
14serine4510.2CCNA2, S100B, DES, MKI67, NME1
15eb 108945 6011.2CCNA2, IFI27, IGF2, CDK2, PCNA
16etoposide45 50 60 1113.2VIM, CCNA2, S100B, IGF2, CDK2, LGALS3
17biotin45 11 2412.1VIM, S100A1, DES, MKI67, PCNA, NME1
18steroid4510.1CCL11, CCNA2, IFI27, DES, MKI67, MME
19cytarabine45 50 1112.1VIM, CCNA2, IFI27, CDK2, PCNA, MME
20formaldehyde45 2411.1VIM, S100B, DES, MKI67, PCNA, KIT
212-methoxyethanol4510.1VIM, S100A1, IGF2, ACTC1
22indomethacin45 60 29 1113.0PGR, PCNA, IGF2
235fluorouracil4510.0CCNA2, IGF2, MKI67, CDK2, PCNA, PGR
24p0024510.0IFI27, DES, IGF2, MKI67, NME1, KIT
25cyclosporin a45 29 6011.9CCL11, CCNA2, S100B, CR2, CDK2, PCNA
26dexamethasone45 50 29 1112.9CCL11, CCNA2, IFI27, S100B, IGF2, CDK2
27actinomycin d459.9VIM, CCL11, DES, IGF2, CDK2, MME
28thymidylate459.9VIM, CCNA2, IFI27, MKI67, CDK2, PCNA
29bromodeoxyuridine459.9VIM, CCNA2, IFI27, S100B, DES, MKI67
30hematoxylin459.9LGALS3, ACTC1, KIT, PCNA, MKI67, DES
31doxorubicin45 50 1111.9VIM, CCNA2, IFI27, DES, MKI67, CDK2
32cisplatin45 50 60 1112.8CCNA2, IFI27, IGF2, MKI67, CDK2, PCNA
33estradiol45 11 2411.8VIM, CCNA2, IFI27, DES, IGF2, MKI67
34nitric oxide45 11 2411.8S100A1, S100B, CCNA2, CCL11, DES, MKI67
35lactate459.8VIM, IFI27, S100B, DES, IGF2, MKI67
36methionine459.8KIT, MME, CDK2, DES, S100B, IFI27
37threonine459.8CCL11, CCNA2, IFI27, S100B, CR2, DES
38alanine459.7S100B, CCNA2, CCL11, VIM, IGF2, CDK2
39cysteine459.7VIM, S100B, S100A1, DES, IGF2, PCNA
40thymidine45 2410.7KIT, NME1, MME, PCNA, CDK2, MKI67
41arginine459.7VIM, CCNA2, IFI27, S100B, DES, IGF2
42roscovitine459.6VIM, CCNA2, IFI27, CDK2, PCNA
43oxygen45 2410.6CCL11, CCNA2, IFI27, S100B, DES, MKI67
44testosterone45 60 11 2412.6MME, PGR, PCNA, CDK2, MKI67, IGF2
45calcium45 50 11 2412.5S100A1, S100B, IFI27, CALD1, CCNA2, CCL11
46tyrosine459.4CR2, S100A1, S100B, IFI27, CCNA2, CCL11
47vegf459.3PCNA, CDK2, MKI67, IGF2, DES, S100B
48progesterone45 60 29 11 2413.3NME1, VIM, MME, PGR, PCNA, CDK2
49paraffin459.2LGALS3, ACTC1, HMGA2, KIT, NME1, MME
50retinoic acid45 2410.1LGALS3, CCNA2, CCL11, VIM, IFI27, S100B

GO Terms for genes affiliated with Smooth Muscle Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057379.3LGALS3, CCNA2, S100B, MKI67, CDK2, PCNA

Biological processes related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic G2 DNA damage checkpointGO:00709510.3HMGA2, CCNA2
2muscle filament slidingGO:03004910.1ACTC1, DES, VIM
3mast cell chemotaxisGO:00255110.0KIT, CCL11

Molecular functions related to Smooth Muscle Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.3S100A1, S100B
2identical protein bindingGO:0428029.6VIM, S100B, S100A1, DES, PCNA, NME1
3protein bindingGO:0055158.7LGALS3, VIM, CCL11, CCNA2, S100B, S100A1

Products for genes affiliated with Smooth Muscle Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Smooth Muscle Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet