MCID: SNC002
MIFTS: 27

Snca-Related Parkinson Disease malady

Categories: Genetic diseases, Neuronal diseases, Mental diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Snca-Related Parkinson Disease

Aliases & Descriptions for Snca-Related Parkinson Disease:

Name: Snca-Related Parkinson Disease 24
Parkinson Disease, Autosomal Dominant 24 52
Parkinson Disease, Familial, Type 1 69
Lewy Body Parkinsonism 24

Classifications:



Summaries for Snca-Related Parkinson Disease

MalaCards based summary : Snca-Related Parkinson Disease, also known as parkinson disease, autosomal dominant, is related to parkinson disease 4 and parkinson disease, late-onset. An important gene associated with Snca-Related Parkinson Disease is SNCA (Synuclein Alpha), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. Related phenotypes are behavior/neurological and renal/urinary system

Related Diseases for Snca-Related Parkinson Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 8
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Juvenile Onset Parkinson Disease 19a
Juvenile-Onset Parkinson Disease Early-Onset Parkinson Disease
Lrrk2-Related Parkinson Disease Parkinson Disease Type 3
Parkinson Disease Type 9 Dnajc6-Related Parkinson Disease
Eif4g1-Related Parkinson Disease Gigyf2-Related Parkinson Disease
Pla2g6-Related Parkinson Disease Synj1-Related Parkinson Disease
Fbxo7-Related Parkinson Disease Htra2-Related Parkinson Disease
Park7-Related Parkinson Disease Snca-Related Parkinson Disease
Vps35-Related Parkinson Disease Hereditary Late-Onset Parkinson Disease
Parkinson Disease 22 Parkinson Disease 23, Autosomal Recessive, Early Onset

Diseases related to Snca-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 parkinson disease 4 11.3
2 parkinson disease, late-onset 11.1
3 parkinson disease 1 11.1
4 parkinson disease type 3 11.1
5 transient neonatal myasthenia gravis 10.1 LRRK2 SNCA
6 lower gum cancer 10.1 LRRK2 SNCA
7 thyrotropin-releasing hormone deficiency 10.1 LRRK2 SNCA
8 parkinson disease 6, early onset 10.1 LRRK2 PARK7
9 deafness, autosomal recessive 101 10.0 MAPT SNCA
10 lethal congenital contracture syndrome 8 9.9 LRRK2 PARK7 SNCA
11 juvenile amyotrophic lateral sclerosis with dementia 9.9 MAPT SNCA
12 thrombosis 9.9 LRRK2 PARK7 SNCA
13 cyprus facial neuromusculoskeletal syndrome 9.9 MAPT SNCA
14 multiple system atrophy 9.9 PARK7 SNCA SNCAIP
15 atrial septal defect 9 9.9 MAPT SNCA
16 riedel's fibrosing thyroiditis 9.9 LRRK2 MAPT SNCA
17 mitochondrial dna depletion syndrome 3 9.9 MAPT SNCA
18 benign partial epilepsy with secondarily generalized seizures in infancy 9.8 LRRK2 MAPT SNCA
19 autoimmune disease of urogenital tract 9.8 LRRK2 MAPT SNCA
20 autism 19 9.8 LRRK2 MAPT SNCA
21 epithelioid type angiomyolipoma 9.8 LRRK2 MAPT SNCA
22 neurosarcoidosis 9.8 MAPT SNCA
23 ceroid lipofuscinosis, neuronal, 1 9.8 LRRK2 PARK7 PRKN SNCA
24 trichothiodystrophy 3, photosensitive 9.8 LRRK2 PARK7 PRKN SNCA
25 klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism 9.7 LRRK2 PARK7 PRKN SNCA
26 dementia, lewy body 9.7
27 dementia 9.7
28 cardiomyopathy, dilated, 1u 9.7 LRRK2 MAPT PRKN SNCA
29 eumycotic mycetoma 9.6 LRRK2 MAPT SNCA SNCAIP
30 plekhm1-related autosomal recessive osteopetrosis 9.6 LRRK2 MAPT PARK7 SNCA
31 meier-gorlin syndrome 5 9.6 LRRK2 MAPT PARK7 SNCA
32 substance-induced psychosis 9.6 LRRK2 MAPT PARK7 SNCA
33 hypoproteinemia, hypercatabolic 9.4 LRRK2 MAPT PARK7 PRKN SNCA
34 cavernous hemangioma 9.4 LRRK2 MAPT PARK7 PRKN SNCA
35 coenzyme q10 deficiency, primary, 1 9.2 LRRK2 MAPT PARK7 PRKN SNCA SNCAIP
36 gallbladder adenoma 9.2 LRRK2 MAPT PARK7 PRKN SNCA SNCAIP
37 spink1-related hereditary pancreatitis 9.1 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
38 hemochromatosis, type 2a 9.1 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA

Graphical network of the top 20 diseases related to Snca-Related Parkinson Disease:



Diseases related to Snca-Related Parkinson Disease

Symptoms & Phenotypes for Snca-Related Parkinson Disease

MGI Mouse Phenotypes related to Snca-Related Parkinson Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
2 renal/urinary system MP:0005367 8.92 LRRK1 LRRK2 MAPT SNCA

Drugs & Therapeutics for Snca-Related Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Snca-Related Parkinson Disease

Genetic Tests for Snca-Related Parkinson Disease

Genetic tests related to Snca-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Snca-Related Parkinson Disease 24 SNCA

Anatomical Context for Snca-Related Parkinson Disease

Publications for Snca-Related Parkinson Disease

Variations for Snca-Related Parkinson Disease

Expression for Snca-Related Parkinson Disease

Search GEO for disease gene expression data for Snca-Related Parkinson Disease.

Pathways for Snca-Related Parkinson Disease

GO Terms for Snca-Related Parkinson Disease

Cellular components related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.91 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
2 mitochondrion GO:0005739 9.8 LRRK1 LRRK2 PARK7 PRKN SNCA
3 neuron projection GO:0043005 9.63 LRRK2 PARK7 PRKN
4 cell body GO:0044297 9.54 MAPT PARK7
5 presynapse GO:0098793 9.52 PARK7 PRKN
6 terminal bouton GO:0043195 9.51 LRRK2 SNCA
7 mitochondrial respiratory chain complex I GO:0005747 9.49 PARK7 SNCA
8 postsynapse GO:0098794 9.43 LRRK2 SNCA
9 growth cone GO:0030426 9.43 LRRK2 MAPT SNCA
10 synaptic vesicle GO:0008021 9.33 LRRK2 SNCA SNCAIP
11 inclusion body GO:0016234 9.32 LRRK2 SNCA
12 neuronal cell body GO:0043025 9.26 LRRK2 MAPT SNCA SNCAIP
13 axon GO:0030424 8.92 LRRK2 MAPT PARK7 SNCA
14 cytoplasm GO:0005737 10.02 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA

Biological processes related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 42)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.83 PRKN SNCA SNCAIP
2 negative regulation of gene expression GO:0010629 9.81 MAPT PARK7 PRKN
3 autophagy GO:0006914 9.8 LRRK2 PARK7 PRKN
4 negative regulation of neuron apoptotic process GO:0043524 9.79 PARK7 PRKN SNCA
5 cellular response to oxidative stress GO:0034599 9.74 LRRK2 PARK7 SNCA
6 mitochondrion organization GO:0007005 9.73 LRRK2 PARK7 PRKN
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.69 MAPT SNCA
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.68 PARK7 SNCA
9 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.68 LRRK2 PRKN
10 excitatory postsynaptic potential GO:0060079 9.68 LRRK2 SNCA
11 negative regulation of cell death GO:0060548 9.68 PARK7 PRKN
12 positive regulation of protein binding GO:0032092 9.67 LRRK2 PRKN
13 negative regulation of protein binding GO:0032091 9.67 LRRK2 PARK7
14 synapse organization GO:0050808 9.67 MAPT SNCA
15 adult locomotory behavior GO:0008344 9.67 PARK7 PRKN SNCA
16 protein destabilization GO:0031648 9.66 PRKN SNCA
17 regulation of mitochondrial membrane potential GO:0051881 9.66 PARK7 PRKN
18 regulation of canonical Wnt signaling pathway GO:0060828 9.65 LRRK2 PRKN
19 regulation of reactive oxygen species metabolic process GO:2000377 9.65 PRKN SNCA
20 regulation of autophagy GO:0010506 9.65 LRRK2 MAPT PRKN
21 regulation of dopamine secretion GO:0014059 9.64 PRKN SNCA
22 regulation of neuron death GO:1901214 9.64 LRRK2 SNCA
23 cellular response to dopamine GO:1903351 9.62 LRRK2 PRKN
24 microglial cell activation GO:0001774 9.62 MAPT SNCA
25 supramolecular fiber organization GO:0097435 9.61 MAPT SNCA
26 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.6 LRRK2 PARK7
27 positive regulation of mitophagy GO:1903599 9.59 PARK7 PRKN
28 intracellular distribution of mitochondria GO:0048312 9.58 LRRK2 MAPT
29 regulation of locomotion GO:0040012 9.58 LRRK2 SNCA
30 synaptic transmission, dopaminergic GO:0001963 9.58 PARK7 PRKN SNCA
31 regulation of mitochondrial fission GO:0090140 9.55 LRRK2 MAPT
32 protein localization to mitochondrion GO:0070585 9.54 LRRK2 PRKN
33 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.54 LRRK2 PARK7 PRKN
34 cellular response to manganese ion GO:0071287 9.52 LRRK2 PRKN
35 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 9.51 PARK7 PRKN
36 regulation of neurotransmitter secretion GO:0046928 9.5 PRKN SNCA SNCAIP
37 regulation of synaptic vesicle transport GO:1902803 9.46 LRRK2 PRKN
38 negative regulation of protein phosphorylation GO:0001933 9.46 LRRK2 PARK7 PRKN SNCA
39 negative regulation of oxidative stress-induced cell death GO:1903202 9.43 PARK7 PRKN
40 dopamine metabolic process GO:0042417 9.43 PRKN SNCA SNCAIP
41 negative regulation of neuron death GO:1901215 9.26 LRRK2 PARK7 PRKN SNCA
42 dopamine uptake involved in synaptic transmission GO:0051583 8.8 PARK7 PRKN SNCA

Molecular functions related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.63 LRRK2 MAPT PRKN
2 microtubule binding GO:0008017 9.58 LRRK2 MAPT SNCA
3 enzyme binding GO:0019899 9.56 MAPT PARK7 PRKN SNCA
4 copper ion binding GO:0005507 9.48 PARK7 SNCA
5 Hsp70 protein binding GO:0030544 9.43 PRKN SNCA
6 phospholipase binding GO:0043274 9.37 PRKN SNCA
7 ubiquitin-specific protease binding GO:1990381 9.32 PARK7 PRKN
8 identical protein binding GO:0042802 9.17 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
9 cuprous ion binding GO:1903136 9.16 PARK7 SNCA
10 tubulin binding GO:0015631 9.13 LRRK2 MAPT PRKN

Sources for Snca-Related Parkinson Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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