MCID: SNC002
MIFTS: 32

Snca-Related Parkinson Disease malady

Categories: Genetic diseases, Neuronal diseases, Mental diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Snca-Related Parkinson Disease

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Sources:
22GeneTests, 47Novoseek, 65UMLS
See all MalaCards sources

Aliases & Descriptions for Snca-Related Parkinson Disease:

Name: Snca-Related Parkinson Disease 22
Parkinson Disease, Autosomal Dominant 22 47
 
Parkinson Disease, Familial, Type 1 65
Lewy Body Parkinsonism 22

Classifications:



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UMLS65 C3489791

Summaries for Snca-Related Parkinson Disease

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MalaCards based summary: Snca-Related Parkinson Disease, also known as parkinson disease, autosomal dominant, is related to parkinson disease 1 and parkinson disease, late-onset. An important gene associated with Snca-Related Parkinson Disease is SNCA (Synuclein Alpha), and among its related pathways are Proteolysis_Putative ubiquitin pathway and Parkin-Ubiquitin Proteasomal System pathway. Affiliated tissues include kidney and colon, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Related Diseases for Snca-Related Parkinson Disease

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Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 8
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Lrrk2-Related Parkinson Disease
Parkinson Disease Type 3 Parkinson Disease Type 9
Dnajc6-Related Parkinson Disease Eif4g1-Related Parkinson Disease
Gigyf2-Related Parkinson Disease Pla2g6-Related Parkinson Disease
Synj1-Related Parkinson Disease Fbxo7-Related Parkinson Disease
Htra2-Related Parkinson Disease Park7-Related Parkinson Disease
snca-related parkinson disease Vps35-Related Parkinson Disease
Hereditary Late-Onset Parkinson Disease

Diseases related to Snca-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson disease 129.0LRRK2, MAPT, PARK2, PARK7, SNCA, SNCAIP
2parkinson disease, late-onset28.3LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA
3parkinson disease 411.2
4angelman syndrome due to a point mutation10.3LRRK2, SNCA
5esophagus carcinoma in situ10.3LRRK2, SNCA
6retinoblastoma fa - friedreich ataxia10.2MAPT, SNCA
7dysphagia10.2SNCA, SNCAIP
8isolated tracheo-esophageal fistula10.2LRRK2, MAPT
9estrogen excess10.2MAPT, SNCA
10neuropathy ataxia retinitis pigmentosa syndrome10.1MAPT, SNCA
11atrioventricular septal defect 510.1MAPT, SNCA
12hyperlipidemia type 310.1
13perry syndrome10.0MAPT, SNCA
14dementia10.0
15writing disorder9.9LRRK2, MAPT
16candidiasis9.9MAPT, SNCA
17hypotrichosis 79.8PARK2, SNCA
18cardiomyopathy, dilated, 1u9.7MAPT, SNCA
19aspartylglucosaminuria9.6LRRK2, PARK2
20essential tremor9.6LRRK2, PARK2, SNCA
21iron-refractory iron deficiency anemia9.4PARK2, PARK7, SNCA
22parkinson disease 6, early onset9.4LRRK2, PARK2, PARK7
23epilepsy, progressive myoclonic 1b9.4LRRK2, PARK2, PARK7
24pde6d-related joubert syndrome9.3LRRK2, MAPT, PARK7, SNCA
25vascular erectile tumor9.1LRRK2, MAPT, PARK2, SNCA
26polycystic kidney disease 29.1LRRK2, MAPT, PARK2, SNCA
27pick disease9.1LRRK2, MAPT, PARK2, SNCA
28celiac disease 129.1LRRK2, PARK2, PARK7, SNCA
29coenzyme q10 deficiency, primary, 18.9PARK2, PARK7, SNCA, SNCAIP
30mast syndrome8.6LRRK2, MAPT, PARK2, PARK7, SNCA
31supranuclear palsy, progressive atypical8.6LRRK2, MAPT, PARK2, PARK7, SNCA
32central nervous system hereditary degenerative disease8.6LRRK2, MAPT, PARK2, PARK7, SNCA
33upper lip cancer8.5LRRK2, MAPT, PARK2, PARK7, SNCA
34colon kaposi sarcoma8.5LRRK2, MAPT, PARK2, PARK7, SNCA
35atopic dermatitis8.5LRRK2, MAPT, PARK2, PARK7, SNCA
36acquired hyperkeratosis8.4MAPT, PARK2, PARK7, SNCA, SNCAIP
37adrenal cortical adenoma8.1LRRK2, MAPT, PARK2, PARK7, SNCA, SNCAIP
38snrnp200-related retinitis pigmentosa7.6LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA

Graphical network of the top 20 diseases related to Snca-Related Parkinson Disease:



Diseases related to snca-related parkinson disease

Symptoms for Snca-Related Parkinson Disease

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Drugs & Therapeutics for Snca-Related Parkinson Disease

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Snca-Related Parkinson Disease

Genetic Tests for Snca-Related Parkinson Disease

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Genetic tests related to Snca-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Snca-Related Parkinson Disease22 SNCA

Anatomical Context for Snca-Related Parkinson Disease

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MalaCards organs/tissues related to Snca-Related Parkinson Disease:

33
Kidney, Colon

Animal Models for Snca-Related Parkinson Disease or affiliated genes

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MGI Mouse Phenotypes related to Snca-Related Parkinson Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4LRRK1, LRRK2, MAPT, SNCA
2MP:00030128.4LRRK2, MAPT, PARK2, SNCA
3MP:00053867.3LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA
4MP:00053767.3LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA

Publications for Snca-Related Parkinson Disease

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Variations for Snca-Related Parkinson Disease

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Expression for genes affiliated with Snca-Related Parkinson Disease

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Search GEO for disease gene expression data for Snca-Related Parkinson Disease.

Pathways for genes affiliated with Snca-Related Parkinson Disease

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GO Terms for genes affiliated with Snca-Related Parkinson Disease

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Cellular components related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.1LRRK2, PARK7, SNCA

Biological processes related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of neuron deathGO:190121410.2LRRK2, SNCA
2dopamine metabolic processGO:004241710.1SNCA, SNCAIP
3negative regulation of hydrogen peroxide-induced cell deathGO:190320610.0LRRK2, PARK7
4negative regulation of neuron deathGO:19012159.8PARK7, SNCA
5cellular response to oxidative stressGO:00345999.8LRRK2, PARK7
6positive regulation of peptidyl-serine phosphorylationGO:00331389.7PARK7, SNCA
7dopamine uptake involved in synaptic transmissionGO:00515839.7PARK2, SNCA
8adult locomotory behaviorGO:00083449.7PARK7, SNCA
9cellular response to dopamineGO:19033519.7LRRK2, PARK2
10regulation of canonical Wnt signaling pathwayGO:00608289.6LRRK2, PARK2
11protein localization to mitochondrionGO:00705859.6LRRK2, PARK2
12regulation of neurotransmitter secretionGO:00469289.6PARK2, SNCA
13negative regulation of neuron apoptotic processGO:00435249.6PARK2, SNCA
14negative regulation of cell deathGO:00605489.0PARK2, PARK7
15mitochondrion organizationGO:00070058.9LRRK2, PARK2, PARK7
16synaptic transmission, dopaminergicGO:00019638.7PARK2, PARK7, SNCA
17response to oxidative stressGO:00069798.5LRRK2, PARK2, PARK7
18negative regulation of protein phosphorylationGO:00019338.3LRRK2, PARK2, PARK7

Sources for Snca-Related Parkinson Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet