MCID: SNC002
MIFTS: 27

Snca-Related Parkinson Disease malady

Categories: Genetic diseases, Neuronal diseases, Mental diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Snca-Related Parkinson Disease

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Sources:
24GeneTests, 49Novoseek, 67UMLS
See all MalaCards sources

Aliases & Descriptions for Snca-Related Parkinson Disease:

Name: Snca-Related Parkinson Disease 24
Parkinson Disease, Autosomal Dominant 24 49
 
Parkinson Disease, Familial, Type 1 67
Lewy Body Parkinsonism 24

Classifications:



Summaries for Snca-Related Parkinson Disease

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MalaCards based summary: Snca-Related Parkinson Disease, also known as parkinson disease, autosomal dominant, is related to parkinson disease 1 and parkinson disease, late-onset. An important gene associated with Snca-Related Parkinson Disease is SNCA (Synuclein Alpha), and among its related pathways are Proteolysis_Putative ubiquitin pathway and Alpha-synuclein signaling. Related mouse phenotypes are renal/urinary system and behavior/neurological.

Related Diseases for Snca-Related Parkinson Disease

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Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 8
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Lrrk2-Related Parkinson Disease
Parkinson Disease Type 3 Parkinson Disease Type 9
Dnajc6-Related Parkinson Disease Eif4g1-Related Parkinson Disease
Gigyf2-Related Parkinson Disease Pla2g6-Related Parkinson Disease
Synj1-Related Parkinson Disease Fbxo7-Related Parkinson Disease
Htra2-Related Parkinson Disease Park7-Related Parkinson Disease
snca-related parkinson disease Vps35-Related Parkinson Disease
Hereditary Late-Onset Parkinson Disease Parkinson Disease 22
Parkinson Disease 23, Autosomal Recessive, Early Onset

Diseases related to Snca-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson disease 129.8LRRK2, MAPT, PARK2, SNCA, SNCAIP
2parkinson disease, late-onset28.4LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA
3parkinson disease 411.1
4parkinson disease type 311.1
5hyperlipidemia type 311.0
6angelman syndrome due to imprinting defect in 15q11-q1310.3LRRK2, SNCA
7erythematosquamous dermatosis10.2LRRK2, SNCA
8suppurative thyroiditis10.1MAPT, SNCA
9basilar impression, primary10.1MAPT, SNCA
10atrial septal defect 910.1MAPT, SNCA
11myoclonic encephalopathy of infants10.0MAPT, SNCA
12perry syndrome10.0MAPT, SNCA
13adult brain stem glioma9.9MAPT, SNCA
14avoidant personality disorder9.9MAPT, SNCA
15dementia9.9
16epileptic hemiplegia9.9PARK2, SNCA
17anti-p200 pemphigoid9.9LRRK2, MAPT, SNCA
18vaginal tubular adenoma9.8LRRK2, MAPT, SNCA
19nosophobia9.8LRRK2, MAPT
20hypotrichosis 79.8PARK2, SNCA
21rem sleep behavior disorder9.7
22cardiomyopathy, dilated, 1u9.7MAPT, SNCA
23essential tremor9.6LRRK2, PARK2, SNCA
24tinea unguium9.5MAPT, PARK2, SNCA
25klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism9.4PARK2, PARK7, SNCA
26parkinson disease 6, early onset9.4LRRK2, PARK2, PARK7
27whiplash9.2LRRK2, MAPT, PARK2, SNCA
28polycystic kidney disease 29.2LRRK2, MAPT, PARK2, SNCA
29pick disease9.2LRRK2, MAPT, PARK2, SNCA
30parkinson disease 109.1LRRK2, PARK2, PARK7, SNCA
31celiac disease 129.1LRRK2, PARK2, PARK7, SNCA
32epilepsy, progressive myoclonic 1b9.1LRRK2, PARK2, PARK7, SNCA
33coenzyme q10 deficiency, primary, 19.0PARK2, PARK7, SNCA, SNCAIP
34phka2-related phosphorylase kinase deficiency8.7LRRK2, MAPT, PARK2, PARK7, SNCA
35mast syndrome8.7LRRK2, MAPT, PARK2, PARK7, SNCA
36meier-gorlin syndrome 58.7LRRK2, MAPT, PARK2, PARK7, SNCA
37angiomyolipoma8.6LRRK2, MAPT, PARK2, PARK7, SNCA
38chronic intestinal vascular insufficiency8.6LRRK2, MAPT, PARK2, PARK7, SNCA
39adrenal gland pheochromocytoma8.2LRRK2, MAPT, PARK2, PARK7, SNCA, SNCAIP

Graphical network of the top 20 diseases related to Snca-Related Parkinson Disease:



Diseases related to snca-related parkinson disease

Symptoms for Snca-Related Parkinson Disease

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Drugs & Therapeutics for Snca-Related Parkinson Disease

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Snca-Related Parkinson Disease

Genetic Tests for Snca-Related Parkinson Disease

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Genetic tests related to Snca-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Snca-Related Parkinson Disease24 SNCA

Anatomical Context for Snca-Related Parkinson Disease

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Animal Models for Snca-Related Parkinson Disease or affiliated genes

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MGI Mouse Phenotypes related to Snca-Related Parkinson Disease:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7LRRK1, LRRK2, MAPT, SNCA
2MP:00053868.1LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA
3MP:00053768.0LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA

Publications for Snca-Related Parkinson Disease

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Variations for Snca-Related Parkinson Disease

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Expression for genes affiliated with Snca-Related Parkinson Disease

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Search GEO for disease gene expression data for Snca-Related Parkinson Disease.

Pathways for genes affiliated with Snca-Related Parkinson Disease

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GO Terms for genes affiliated with Snca-Related Parkinson Disease

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Cellular components related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:001623410.4LRRK2, SNCA
2mitochondrial respiratory chain complex IGO:000574710.2PARK7, SNCA
3postsynapseGO:009879410.2LRRK2, SNCA
4terminal boutonGO:00431959.9LRRK2, SNCA
5synaptic vesicleGO:00080219.6LRRK2, SNCA, SNCAIP
6presynapseGO:00987939.6PARK2, PARK7
7cell bodyGO:00442979.4MAPT, PARK7
8growth coneGO:00304269.3LRRK2, MAPT, SNCA
9neuron projectionGO:00430058.9LRRK2, PARK2, PARK7
10axonGO:00304248.5LRRK2, MAPT, PARK7, SNCA
11mitochondrionGO:00057398.1LRRK1, LRRK2, PARK2, PARK7, SNCA
12cytosolGO:00058297.4LRRK2, MAPT, PARK2, PARK7, SNCA, SNCAIP
13cytoplasmGO:00057376.4LRRK1, LRRK2, MAPT, PARK2, PARK7, SNCA

Biological processes related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1regulation of neuron deathGO:190121410.1LRRK2, SNCA
2excitatory postsynaptic potentialGO:006007910.1LRRK2, SNCA
3negative regulation of hydrogen peroxide-induced cell deathGO:190320610.1LRRK2, PARK7
4regulation of synaptic vesicle transportGO:19028039.9LRRK2, PARK2
5cellular response to manganese ionGO:00712879.8LRRK2, PARK2
6negative regulation of protein bindingGO:00320919.8LRRK2, PARK7
7positive regulation of peptidyl-serine phosphorylationGO:00331389.8PARK7, SNCA
8regulation of canonical Wnt signaling pathwayGO:00608289.7LRRK2, PARK2
9regulation of locomotionGO:00400129.7LRRK2, SNCA
10protein destabilizationGO:00316489.7PARK2, SNCA
11negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayGO:19033779.7PARK2, PARK7
12negative regulation of oxidative stress-induced cell deathGO:19032029.7PARK2, PARK7
13regulation of reactive oxygen species metabolic processGO:20003779.7PARK2, SNCA
14positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:00324369.7LRRK2, PARK2
15cellular response to dopamineGO:19033519.6LRRK2, PARK2
16regulation of mitochondrial membrane potentialGO:00518819.6PARK2, PARK7
17protein localization to mitochondrionGO:00705859.5LRRK2, PARK2
18negative regulation of cell deathGO:00605489.5PARK2, PARK7
19cellular response to oxidative stressGO:00345999.5LRRK2, PARK7, SNCA
20dopamine uptake involved in synaptic transmissionGO:00515839.3PARK2, PARK7, SNCA
21regulation of dopamine secretionGO:00140599.3PARK2, SNCA
22regulation of neurotransmitter secretionGO:00469289.3PARK2, SNCA, SNCAIP
23cellular protein metabolic processGO:00442679.1PARK2, SNCA, SNCAIP
24negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayGO:19022369.1LRRK2, PARK2, PARK7
25mitochondrion organizationGO:00070059.0LRRK2, PARK2, PARK7
26regulation of autophagyGO:00105069.0LRRK2, MAPT, PARK2
27adult locomotory behaviorGO:00083449.0PARK2, PARK7, SNCA
28negative regulation of neuron apoptotic processGO:00435248.9PARK2, PARK7, SNCA
29negative regulation of neuron deathGO:19012158.7LRRK2, PARK2, PARK7, SNCA
30negative regulation of protein phosphorylationGO:00019338.6LRRK2, PARK2, PARK7, SNCA
31synaptic transmission, dopaminergicGO:00019638.6PARK2, PARK7, SNCA
32dopamine metabolic processGO:00424178.5PARK2, SNCA, SNCAIP

Molecular functions related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.9PARK7, SNCA
2tubulin bindingGO:00156319.7LRRK2, PARK2
3phospholipase bindingGO:00432749.7PARK2, SNCA
4ubiquitin-specific protease bindingGO:19903819.4PARK2, PARK7
5microtubule bindingGO:00080179.3LRRK2, MAPT, SNCA
6enzyme bindingGO:00198998.1MAPT, PARK2, PARK7, SNCA
7identical protein bindingGO:00428027.3LRRK1, LRRK2, PARK2, PARK7, SNCA, SNCAIP

Sources for Snca-Related Parkinson Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet