MCID: SNC002
MIFTS: 27

Snca-Related Parkinson Disease

Categories: Genetic diseases, Neuronal diseases, Mental diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Snca-Related Parkinson Disease

MalaCards integrated aliases for Snca-Related Parkinson Disease:

Name: Snca-Related Parkinson Disease 24
Parkinson Disease, Autosomal Dominant 24 52
Parkinson Disease, Familial, Type 1 69
Lewy Body Parkinsonism 24

Classifications:



Summaries for Snca-Related Parkinson Disease

MalaCards based summary : Snca-Related Parkinson Disease, also known as parkinson disease, autosomal dominant, is related to parkinson disease 1 and parkinson disease, late-onset. An important gene associated with Snca-Related Parkinson Disease is SNCA (Synuclein Alpha), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chks in Checkpoint Regulation. Related phenotypes are behavior/neurological and renal/urinary system

Related Diseases for Snca-Related Parkinson Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19a, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 22, Autosomal Dominant
Parkinson Disease 8 Parkinson Disease 23, Autosomal Recessive, Early Onset
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Juvenile-Onset Parkinson Disease
Early-Onset Parkinson Disease Lrrk2-Related Parkinson Disease
Vps35-Related Parkinson Disease Parkinson Disease Type 3
Parkinson Disease Type 9 Synj1-Related Parkinson Disease
Dnajc6-Related Parkinson Disease Eif4g1-Related Parkinson Disease
Fbxo7-Related Parkinson Disease Gigyf2-Related Parkinson Disease
Htra2-Related Parkinson Disease Park7-Related Parkinson Disease
Pla2g6-Related Parkinson Disease Snca-Related Parkinson Disease
Hereditary Late-Onset Parkinson Disease

Diseases related to Snca-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 parkinson disease 1 28.6 LRRK2 MAPT PARK7 PRKN SNCA SNCAIP
2 parkinson disease, late-onset 27.9 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
3 parkinson disease 4 11.3
4 13q12.3 microdeletion syndrome 10.5 LRRK2 SNCA
5 sebaceous gland disease 10.1 LRRK2 SNCA
6 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.0 MAPT SNCA
7 personality disorder 10.0 MAPT SNCA
8 basilar impression, primary 9.9 MAPT SNCA
9 riedel's fibrosing thyroiditis 9.8 LRRK2 MAPT SNCA
10 erb-duchenne and dejerine-klumpke palsies 9.8 PRKN SNCA
11 nosophobia 9.7 LRRK2 MAPT SNCA
12 dementia, lewy body 9.7
13 dementia 9.7
14 atrioventricular septal defect 5 9.7 MAPT SNCA
15 thyrotropin-releasing hormone deficiency 9.4 LRRK2 PRKN SNCA
16 mucopolysaccharidosis iii 9.3 MAPT PRKN SNCA
17 piebald trait, kit-related 9.2 LRRK2 MAPT PARK7 SNCA
18 fastkd2-related infantile mitochondrial encephalomyopathy 9.0 LRRK2 MAPT PRKN SNCA
19 parietal foramina 3 9.0 LRRK2 MAPT PRKN SNCA
20 pick disease 9.0 LRRK2 MAPT PRKN SNCA
21 parkinson disease 10 9.0 LRRK2 PARK7 PRKN SNCA
22 celiac disease 12 9.0 LRRK2 PARK7 PRKN SNCA
23 hepatic angiomyolipoma 8.9 LRRK2 MAPT PRKN SNCA
24 waldenstroem's macroglobulinemia 8.9 LRRK2 PARK7 PRKN SNCA
25 ectodermal dysplasia 13, hair/tooth type 8.9 LRRK2 PARK7 PRKN SNCA
26 mast syndrome 8.5 LRRK2 MAPT PARK7 PRKN SNCA
27 supranuclear palsy, progressive atypical 8.4 LRRK2 MAPT PARK7 PRKN SNCA
28 ganglioneuroma 8.4 LRRK2 MAPT PARK7 PRKN SNCA
29 prostate carcinoma in situ 8.4 LRRK2 MAPT PARK7 PRKN SNCA
30 eumycotic mycetoma 8.3 MAPT PARK7 PRKN SNCA SNCAIP
31 adrenal gland pheochromocytoma 7.9 LRRK2 MAPT PARK7 PRKN SNCA SNCAIP
32 sparc-related osteogenesis imperfecta 7.5 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA

Graphical network of the top 20 diseases related to Snca-Related Parkinson Disease:



Diseases related to Snca-Related Parkinson Disease

Symptoms & Phenotypes for Snca-Related Parkinson Disease

MGI Mouse Phenotypes related to Snca-Related Parkinson Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
2 renal/urinary system MP:0005367 8.92 LRRK1 LRRK2 MAPT SNCA

Drugs & Therapeutics for Snca-Related Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Snca-Related Parkinson Disease

Genetic Tests for Snca-Related Parkinson Disease

Genetic tests related to Snca-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Snca-Related Parkinson Disease 24 SNCA

Anatomical Context for Snca-Related Parkinson Disease

Publications for Snca-Related Parkinson Disease

Variations for Snca-Related Parkinson Disease

Expression for Snca-Related Parkinson Disease

Search GEO for disease gene expression data for Snca-Related Parkinson Disease.

Pathways for Snca-Related Parkinson Disease

GO Terms for Snca-Related Parkinson Disease

Cellular components related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.91 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
2 mitochondrion GO:0005739 9.8 LRRK1 LRRK2 PARK7 PRKN SNCA
3 neuron projection GO:0043005 9.63 LRRK2 PARK7 PRKN
4 cell body GO:0044297 9.55 MAPT PARK7
5 presynapse GO:0098793 9.54 PARK7 PRKN
6 terminal bouton GO:0043195 9.52 LRRK2 SNCA
7 mitochondrial respiratory chain complex I GO:0005747 9.49 PARK7 SNCA
8 postsynapse GO:0098794 9.43 LRRK2 SNCA
9 growth cone GO:0030426 9.43 LRRK2 MAPT SNCA
10 synaptic vesicle GO:0008021 9.33 LRRK2 SNCA SNCAIP
11 inclusion body GO:0016234 9.32 LRRK2 SNCA
12 neuronal cell body GO:0043025 9.26 LRRK2 MAPT SNCA SNCAIP
13 cytoplasmic ribonucleoprotein granule GO:0036464 9.21 MAPT
14 axon GO:0030424 8.92 LRRK2 MAPT PARK7 SNCA
15 cytoplasm GO:0005737 10.02 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA

Biological processes related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 43)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.83 PRKN SNCA SNCAIP
2 negative regulation of gene expression GO:0010629 9.82 MAPT PARK7 PRKN
3 autophagy GO:0006914 9.8 LRRK2 PARK7 PRKN
4 negative regulation of neuron apoptotic process GO:0043524 9.78 PARK7 PRKN SNCA
5 cellular response to oxidative stress GO:0034599 9.74 LRRK2 PARK7 SNCA
6 mitochondrion organization GO:0007005 9.73 LRRK2 PARK7 PRKN
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.69 MAPT SNCA
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.69 PARK7 SNCA
9 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.68 LRRK2 PRKN
10 negative regulation of cell death GO:0060548 9.68 PARK7 PRKN
11 excitatory postsynaptic potential GO:0060079 9.68 LRRK2 SNCA
12 positive regulation of protein binding GO:0032092 9.68 LRRK2 PRKN
13 negative regulation of protein binding GO:0032091 9.67 LRRK2 PARK7
14 protein destabilization GO:0031648 9.67 PRKN SNCA
15 synapse organization GO:0050808 9.67 MAPT SNCA
16 regulation of mitochondrial membrane potential GO:0051881 9.66 PARK7 PRKN
17 regulation of reactive oxygen species metabolic process GO:2000377 9.65 PRKN SNCA
18 regulation of canonical Wnt signaling pathway GO:0060828 9.65 LRRK2 PRKN
19 regulation of autophagy GO:0010506 9.65 LRRK2 MAPT PRKN
20 regulation of dopamine secretion GO:0014059 9.64 PRKN SNCA
21 regulation of neuron death GO:1901214 9.63 LRRK2 SNCA
22 adult locomotory behavior GO:0008344 9.63 PARK7 PRKN SNCA
23 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.62 LRRK2 PARK7
24 microglial cell activation GO:0001774 9.62 MAPT SNCA
25 cellular response to dopamine GO:1903351 9.61 LRRK2 PRKN
26 supramolecular fiber organization GO:0097435 9.6 MAPT SNCA
27 regulation of locomotion GO:0040012 9.59 LRRK2 SNCA
28 regulation of mitochondrial fission GO:0090140 9.58 LRRK2 MAPT
29 intracellular distribution of mitochondria GO:0048312 9.58 LRRK2 MAPT
30 synaptic transmission, dopaminergic GO:0001963 9.58 PARK7 PRKN SNCA
31 positive regulation of mitophagy GO:1903599 9.55 PARK7 PRKN
32 protein localization to mitochondrion GO:0070585 9.54 LRRK2 PRKN
33 regulation of neurotransmitter secretion GO:0046928 9.54 PRKN SNCA SNCAIP
34 cellular response to manganese ion GO:0071287 9.52 LRRK2 PRKN
35 negative regulation of oxidative stress-induced cell death GO:1903202 9.51 PARK7 PRKN
36 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.5 LRRK2 PARK7 PRKN
37 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 9.49 PARK7 PRKN
38 negative regulation of protein phosphorylation GO:0001933 9.46 LRRK2 PARK7 PRKN SNCA
39 regulation of synaptic vesicle transport GO:1902803 9.43 LRRK2 PRKN
40 dopamine metabolic process GO:0042417 9.43 PRKN SNCA SNCAIP
41 positive regulation of neuron death GO:1901216 9.36 MAPT
42 negative regulation of neuron death GO:1901215 9.26 LRRK2 PARK7 PRKN SNCA
43 dopamine uptake involved in synaptic transmission GO:0051583 8.8 PARK7 PRKN SNCA

Molecular functions related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.63 LRRK2 MAPT PRKN
2 microtubule binding GO:0008017 9.58 LRRK2 MAPT SNCA
3 enzyme binding GO:0019899 9.56 MAPT PARK7 PRKN SNCA
4 copper ion binding GO:0005507 9.48 PARK7 SNCA
5 Hsp70 protein binding GO:0030544 9.43 PRKN SNCA
6 ubiquitin-specific protease binding GO:1990381 9.37 PARK7 PRKN
7 phospholipase binding GO:0043274 9.32 PRKN SNCA
8 identical protein binding GO:0042802 9.17 LRRK1 LRRK2 MAPT PARK7 PRKN SNCA
9 cuprous ion binding GO:1903136 9.16 PARK7 SNCA
10 tubulin binding GO:0015631 9.13 LRRK2 MAPT PRKN

Sources for Snca-Related Parkinson Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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