Snca-Related Parkinson Disease malady

Categories: Genetic diseases, Neuronal diseases, Mental diseases, Rare diseases, Metabolic diseases

Aliases & Classifications for Snca-Related Parkinson Disease

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24GeneTests, 50Novoseek, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Snca-Related Parkinson Disease:

Name: Snca-Related Parkinson Disease 24
Parkinson Disease, Autosomal Dominant 24 50
Parkinson Disease, Familial, Type 1 68
Lewy Body Parkinsonism 24


Summaries for Snca-Related Parkinson Disease

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MalaCards based summary: Snca-Related Parkinson Disease, also known as parkinson disease, autosomal dominant, is related to parkinson disease 4 and parkinson disease, late-onset. An important gene associated with Snca-Related Parkinson Disease is SNCA (Synuclein Alpha), and among its related pathways are Proteolysis_Putative ubiquitin pathway and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. Related mouse phenotypes are renal/urinary system and behavior/neurological.

Related Diseases for Snca-Related Parkinson Disease

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Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 7, Autosomal Recessive Early-Onset Parkinson Disease 6, Early Onset
Parkinson Disease 19, Juvenile-Onset Parkinson Disease 10
Parkinson Disease 16 Parkinson Disease 13
Parkinson Disease 11 Parkinson Disease 21
Parkinson Disease 18 Parkinson Disease 5
Parkinson Disease 4 Parkinson Disease 1
Parkinson Disease, Juvenile, Type 2 Parkinson Disease 8
Parkinson Disease 17 Parkinson Disease 20, Early-Onset
Parkinson Disease 15, Autosomal Recessive Parkinson Disease 14, Autosomal Recessive
Parkinson Disease 12 Juvenile Onset Parkinson Disease 19a
Juvenile-Onset Parkinson Disease Early-Onset Parkinson Disease
Lrrk2-Related Parkinson Disease Parkinson Disease Type 3
Parkinson Disease Type 9 Dnajc6-Related Parkinson Disease
Eif4g1-Related Parkinson Disease Gigyf2-Related Parkinson Disease
Pla2g6-Related Parkinson Disease Synj1-Related Parkinson Disease
Fbxo7-Related Parkinson Disease Htra2-Related Parkinson Disease
Park7-Related Parkinson Disease snca-related parkinson disease
Vps35-Related Parkinson Disease Hereditary Late-Onset Parkinson Disease
Parkinson Disease 22 Parkinson Disease 23, Autosomal Recessive, Early Onset

Diseases related to Snca-Related Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson disease 411.3
2parkinson disease, late-onset11.1
3parkinson disease 111.1
4parkinson disease type 311.1
5transient neonatal myasthenia gravis10.1LRRK2, SNCA
6lower gum cancer10.1LRRK2, SNCA
7thyrotropin-releasing hormone deficiency10.1LRRK2, SNCA
8parkinson disease 6, early onset10.1LRRK2, PARK7
9deafness, autosomal recessive 10110.0MAPT, SNCA
10lethal congenital contracture syndrome 89.9LRRK2, PARK7, SNCA
11juvenile amyotrophic lateral sclerosis with dementia9.9MAPT, SNCA
12thrombosis9.9LRRK2, PARK7, SNCA
13cyprus facial neuromusculoskeletal syndrome9.9MAPT, SNCA
14multiple system atrophy9.9PARK7, SNCA, SNCAIP
15atrial septal defect 99.9MAPT, SNCA
16riedel's fibrosing thyroiditis9.9LRRK2, MAPT, SNCA
17mitochondrial dna depletion syndrome 39.9MAPT, SNCA
18benign partial epilepsy with secondarily generalized seizures in infancy9.8LRRK2, MAPT, SNCA
19autoimmune disease of urogenital tract9.8LRRK2, MAPT, SNCA
20autism 199.8LRRK2, MAPT, SNCA
21epithelioid type angiomyolipoma9.8LRRK2, MAPT, SNCA
22neurosarcoidosis9.8MAPT, SNCA
23ceroid lipofuscinosis, neuronal, 19.8LRRK2, PARK7, PRKN, SNCA
24trichothiodystrophy 3, photosensitive9.8LRRK2, PARK7, PRKN, SNCA
25klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism9.7LRRK2, PARK7, PRKN, SNCA
26dementia, lewy body9.7
28cardiomyopathy, dilated, 1u9.7LRRK2, MAPT, PRKN, SNCA
29eumycotic mycetoma9.6LRRK2, MAPT, SNCA, SNCAIP
30plekhm1-related autosomal recessive osteopetrosis9.6LRRK2, MAPT, PARK7, SNCA
31meier-gorlin syndrome 59.6LRRK2, MAPT, PARK7, SNCA
32substance-induced psychosis9.6LRRK2, MAPT, PARK7, SNCA
33hypoproteinemia, hypercatabolic9.4LRRK2, MAPT, PARK7, PRKN, SNCA
34cavernous hemangioma9.4LRRK2, MAPT, PARK7, PRKN, SNCA
35coenzyme q10 deficiency, primary, 19.2LRRK2, MAPT, PARK7, PRKN, SNCA, SNCAIP
36gallbladder adenoma9.2LRRK2, MAPT, PARK7, PRKN, SNCA, SNCAIP
37spink1-related hereditary pancreatitis9.1LRRK1, LRRK2, MAPT, PARK7, PRKN, SNCA
38hemochromatosis, type 2a9.1LRRK1, LRRK2, MAPT, PARK7, PRKN, SNCA

Graphical network of the top 20 diseases related to Snca-Related Parkinson Disease:

Diseases related to snca-related parkinson disease

Symptoms & Phenotypes for Snca-Related Parkinson Disease

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MGI Mouse Phenotypes related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4LRRK1, LRRK2, MAPT, SNCA

Drugs & Therapeutics for Snca-Related Parkinson Disease

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Snca-Related Parkinson Disease

Genetic Tests for Snca-Related Parkinson Disease

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Genetic tests related to Snca-Related Parkinson Disease:

id Genetic test Affiliating Genes
1 Snca-Related Parkinson Disease24 SNCA

Anatomical Context for Snca-Related Parkinson Disease

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Publications for Snca-Related Parkinson Disease

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Variations for Snca-Related Parkinson Disease

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Expression for genes affiliated with Snca-Related Parkinson Disease

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Search GEO for disease gene expression data for Snca-Related Parkinson Disease.

Pathways for genes affiliated with Snca-Related Parkinson Disease

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GO Terms for genes affiliated with Snca-Related Parkinson Disease

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Cellular components related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:001623410.4LRRK2, SNCA
2postsynapseGO:009879410.3LRRK2, SNCA
3mitochondrial respiratory chain complex IGO:000574710.2PARK7, SNCA
4presynapseGO:00987939.9PARK7, PRKN
5cell bodyGO:00442979.9MAPT, PARK7
6terminal boutonGO:00431959.7LRRK2, SNCA
7synaptic vesicleGO:00080219.7LRRK2, SNCA, SNCAIP
8growth coneGO:00304269.6LRRK2, MAPT, SNCA
9neuron projectionGO:00430059.6LRRK2, PARK7, PRKN
10axonGO:00304249.1LRRK2, MAPT, PARK7, SNCA
11neuronal cell bodyGO:00430259.0LRRK2, MAPT, SNCA, SNCAIP
12mitochondrionGO:00057398.8LRRK1, LRRK2, PARK7, PRKN, SNCA
13cytoplasmGO:00057377.6LRRK1, LRRK2, MAPT, PARK7, PRKN, SNCA
14cytosolGO:00058297.5LRRK1, LRRK2, MAPT, PARK7, PRKN, SNCA

Biological processes related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1excitatory postsynaptic potentialGO:006007910.4LRRK2, SNCA
2regulation of locomotionGO:004001210.3LRRK2, SNCA
3cellular response to dopamineGO:190335110.3LRRK2, PRKN
4cellular response to manganese ionGO:007128710.3LRRK2, PRKN
5regulation of neuron deathGO:190121410.2LRRK2, SNCA
6protein destabilizationGO:003164810.2PRKN, SNCA
7positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:003243610.2LRRK2, PRKN
8positive regulation of protein bindingGO:003209210.2LRRK2, PRKN
9regulation of dopamine secretionGO:001405910.2PRKN, SNCA
10protein localization to mitochondrionGO:007058510.2LRRK2, PRKN
11negative regulation of hydrogen peroxide-induced cell deathGO:190320610.1LRRK2, PARK7
12regulation of canonical Wnt signaling pathwayGO:006082810.1LRRK2, PRKN
13positive regulation of peptidyl-serine phosphorylationGO:003313810.1PARK7, SNCA
14negative regulation of protein bindingGO:003209110.1LRRK2, PARK7
15regulation of reactive oxygen species metabolic processGO:200037710.1PRKN, SNCA
16regulation of synaptic vesicle transportGO:190280310.0LRRK2, PRKN
17negative regulation of cell deathGO:006054810.0PARK7, PRKN
18activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.0MAPT, SNCA
19negative regulation of oxidative stress-induced cell deathGO:190320210.0PARK7, PRKN
20negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayGO:190337710.0PARK7, PRKN
21microglial cell activationGO:000177410.0MAPT, SNCA
22positive regulation of mitophagyGO:190359910.0PARK7, PRKN
23intracellular distribution of mitochondriaGO:004831210.0LRRK2, MAPT
24regulation of mitochondrial membrane potentialGO:00518819.9PARK7, PRKN
25regulation of mitochondrial fissionGO:00901409.8LRRK2, MAPT
26cellular response to oxidative stressGO:00345999.8LRRK2, PARK7, SNCA
27cellular protein metabolic processGO:00442679.8PRKN, SNCA, SNCAIP
28dopamine metabolic processGO:00424179.8PRKN, SNCA, SNCAIP
29supramolecular fiber organizationGO:00974359.8MAPT, SNCA
30adult locomotory behaviorGO:00083449.7PARK7, PRKN, SNCA
31dopamine uptake involved in synaptic transmissionGO:00515839.7PARK7, PRKN, SNCA
32autophagyGO:00069149.7LRRK2, PARK7, PRKN
33negative regulation of neuron apoptotic processGO:00435249.6PARK7, PRKN, SNCA
34mitochondrion organizationGO:00070059.6LRRK2, PARK7, PRKN
35negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayGO:19022369.6LRRK2, PARK7, PRKN
36synapse organizationGO:00508089.6MAPT, SNCA
37regulation of neurotransmitter secretionGO:00469289.6PRKN, SNCA, SNCAIP
38regulation of autophagyGO:00105069.3LRRK2, MAPT, PRKN
39negative regulation of neuron deathGO:19012159.2LRRK2, PARK7, PRKN, SNCA
40negative regulation of protein phosphorylationGO:00019339.2LRRK2, PARK7, PRKN, SNCA
41negative regulation of gene expressionGO:00106299.2MAPT, PARK7, PRKN
42synaptic transmission, dopaminergicGO:00019639.0PARK7, PRKN, SNCA

Molecular functions related to Snca-Related Parkinson Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1Hsp70 protein bindingGO:003054410.3PRKN, SNCA
2copper ion bindingGO:000550710.2PARK7, SNCA
3cuprous ion bindingGO:190313610.2PARK7, SNCA
4phospholipase bindingGO:004327410.1PRKN, SNCA
5actin bindingGO:00037799.4LRRK2, MAPT, PRKN
6microtubule bindingGO:00080179.4LRRK2, MAPT, SNCA
7ubiquitin-specific protease bindingGO:19903819.3PARK7, PRKN
8tubulin bindingGO:00156319.0LRRK2, MAPT, PRKN
9enzyme bindingGO:00198998.8MAPT, PARK7, PRKN, SNCA
10identical protein bindingGO:00428027.4LRRK1, LRRK2, MAPT, PARK7, PRKN, SNCA

Sources for Snca-Related Parkinson Disease

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31ICD10 via Orphanet
40MESH via Orphanet
53OMIM via Orphanet
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
69UMLS via Orphanet