MCID: SCL003
MIFTS: 54

Social Phobia malady

Neuronal category

Summaries for Social Phobia

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards: Social Phobia, also known as phobic anxiety disorder, is related to anxiety disorder and panic disorder. An important gene associated with Social Phobia is MAOA (monoamine oxidase A), and among its related pathways are superoxide radicals degradation and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs gabapentin and paroxetine and the compounds amperozide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Aliases & Classifications for Social Phobia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

social phobia 8
phobic anxiety disorder 61
phobia, social 61
phobia social 45


External Ids:

Disease Ontology8 DOID:11257
MeSH35 D010698
ICD9CM27 300.23
SNOMED-CT57 192395002, 25501002
NCIt40 C34927
ICD1025 F40.1

Related Diseases for Social Phobia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Social Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.3HTR3A, MAOA, SLC6A4
2panic disorder31.2CCK, HTR1A, HTR3A, SLC6A4, PTK7
3agoraphobia31.1PTK7, MAOA, HTR1A
4generalized anxiety disorder31.0HTR1A, SLC6A4
5obsessive-compulsive disorder30.9HTR1A, HTR3A, DRD2, MAOA, SLC6A4
6premature ejaculation30.4HTR1A, SLC6A4
7bipolar disorder30.4HTR1A, SLC6A4
8parkinson's disease30.3CAT, SOD1, HTR1A, HTR3A, DRD2, MAOA
9borderline personality disorder30.2SLC6A4, MAOA
10attention deficit hyperactivity disorder30.2SLC6A4, MAOA, DRD2
11alcohol dependence30.2SLC6A4, MAOA, NPY, DRD2
12avoidant personality disorder10.9
13specific phobia10.7
14mutism10.5
15body dysmorphic disorder10.4
16separation anxiety disorder10.4
17acne10.3
18strabismus10.3
19elective mutism10.3
20insomnia10.3
21dependent personality disorder10.1
22animal phobia10.1
23withdrawal disorder10.1
24melancholia10.0MAOA
25diarrhea10.0HTR3A
26alexithymia10.0WNT10A
27duodenal ulcer10.0CCK
28cluster headache10.0HTR3A
29cholecystitis10.0CCK
30heroin dependence10.0DRD2
31biliary dyskinesia10.0CCK
32pathological gambling10.0DRD2
33peptic ulcer10.0CCK
34glucose intolerance10.0NPY
35complex regional pain syndrome10.0TACR1
36dyspepsia10.0HTR3A, CCK
37varicocele10.0PRL
38autistic disorder10.0SLC6A4
39gastroparesis10.0HTR3A, CCK
40dermatitis10.0TACR1
41menkes disease10.0SOD1
42insulin resistance10.0NPY
43motion sickness10.0HTR1A, HTR3A
44polycystic ovary syndrome10.0PRL
45restless legs syndrome10.0DRD2, HTR3A
46postcholecystectomy syndrome10.0SOD1
47amyotrophic lateral sclerosis10.0SOD1
48liver cirrhosis10.0NPY
49seasonal affective disorder10.0HTR1A, SLC6A4
50substance abuse10.0SLC6A4, DRD2

Graphical network of the top 20 diseases related to Social Phobia:



Diseases related to social phobia

Clinical Features for Social Phobia

Drugs & Therapeutics for Social Phobia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Social Phobia

Drug clinical trials:

Search ClinicalTrials for Social Phobia

Search NIH Clinical Center for Social Phobia

Search CenterWatch for Social Phobia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Social Phobia

Anatomical Context for Social Phobia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Social Phobia:

33
Brain, Cortex, Heart, Prefrontal cortex, Cingulate cortex, Hypothalamus, Amygdala, Adrenal cortex, Pituitary

Animal Models for Social Phobia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Social Phobia

Sources:
51PubMed
See all sources

Articles related to Social Phobia:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
A randomized controlled trial of individual cognitive therapy, group cognitive behaviour therapy and attentional placebo for adolescent social phobia. (24281563)
2014
2
Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia. (24365384)
2013
3
Virtual environments using video capture for social phobia with psychosis. (23659722)
2013
4
Personality functioning in patients with avoidant personality disorder and social phobia. (23786266)
2013
5
Short forms of the Social Interaction Anxiety Scale and the Social Phobia Scale. (22369684)
2012
6
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. (22099954)
2012
7
Alternative explanation for FMRI findings in social phobia. (21536704)
2011
8
Imagery Rescripting of Early Traumatic Memories in Social Phobia. (22298942)
2011
9
Predictors of response to an attention modification program in generalized social phobia. (21707134)
2011
10
Who is looking at me? The cone of gaze widens in social phobia. (21547777)
2011
11
Latent growth curve analysis of fear during a speech task before and after treatment for social phobia. (21907972)
2011
12
Shyness versus social phobia in US youth. (22007009)
2011
13
Randomized controlled trial of Internet cognitive behavioural treatment for social phobia with and without motivational enhancement strategies. (20932208)
2010
14
Respiratory, autonomic, and experiential responses to repeated inhalations of 20% COa88 enriched air in panic disorder, social phobia, and healthy controls. (20064582)
2010
15
The relations among measurements of informant discrepancies within a multisite trial of treatments for childhood social phobia. (20013046)
2010
16
Self-disclosure, emotional expression and intimacy within romantic relationships of people with social phobia. (19665694)
2009
17
Testing the efficacy of theoretically derived improvements in the treatment of social phobia. (19309190)
2009
18
Stimulus-reinforcement-based decision making and anxiety: impairment in generalized anxiety disorder (GAD) but not in generalized social phobia (GSP). (19102795)
2009
19
Frequency of social phobia and psychometric properties of the Liebowitz social anxiety scale in Parkinson's disease. (18661550)
2008
20
A new proposal for the subtypes of social phobia in a sample of Spanish adolescents. (17367987)
2008
21
A model of the development and maintenance of generalized social phobia. (17959288)
2008
22
Summaries of the Sixth Annual Poster Session of the American Psychoanalytic Association: part I. Distinguishing between shyness and social phobia in college students. (19037129)
2008
23
Biases in interpretation and memory in generalized social phobia. (18489204)
2008
24
About a third of young women are estimated to fully recover from social phobia within 18 months. (18223045)
2008
25
Nefazodone in the treatment of generalized social phobia: a randomized, placebo-controlled trial. (17335328)
2007
26
The relationship between avoidant personality disorder and social phobia: a population-based twin study. (17974938)
2007
27
The utility of the PAI and the MMPI-2 for discriminating PTSD, depression, and social phobia in trauma-exposed college students. (17504890)
2007
28
Moclobemide and cognitive behavioral therapy in the treatment of social phobia. A six-month controlled study and 24 months follow up. (16891998)
2006
29
Cognitive correlates of social phobia among children and adolescents. (16514553)
2006
30
Psychometric properties of the social phobia inventory: further evaluation. (16257387)
2006
31
Do empirically supported treatments generalize to private practice? A benchmark study of a cognitive-behavioural group treatment programme for social phobia. (16480565)
2006
32
Intensive cognitive-behavioral group treatment (CBGT) of social phobia: a randomized controlled study. (16169185)
2006
33
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
34
Involvement of GABAA receptor modulating neuroactive steroids in patients with social phobia. (16226317)
2005
35
EEG mapping in patients with social phobia. (15465293)
2004
36
Social Phobia in an Italian region: do Italian studies show lower frequencies than community surveys conducted in other European countries? (15488146)
2004
37
Changes in self-perception during treatment of social phobia. (15301643)
2004
38
Cognitive therapy is more effective than fluoxetine in people with generalised social phobia. (15273219)
2004
39
Sertraline and exposure therapy in social phobia. (14990530)
2004
40
The burden of social phobia in a Brazilian community and its relationship with socioeconomic circumstances, health status and use of health services: the BambuA- study. (15511115)
2004
41
Predictors of response in generalized social phobia: effect of age of onset. (14709946)
2004
42
An open trial of topiramate in the treatment of generalized social phobia. (15641873)
2004
43
WCA recommendations for the long-term treatment of social phobia. (14767397)
2003
44
Clinical distinctions between selective mutism and social phobia: an investigation of childhood psychopathology. (12960706)
2003
45
A preliminary study of dopamine-mediated prolactin inhibition in generalised social phobia. (12140123)
2002
46
Social phobia and avoidant personality disorder as related to parental history of social anxiety: a general population study. (11227810)
2001
47
Pharmacotherapy for social phobia: what works, what might work, and what does not work at all. (18438305)
1999
48
Distinguishing panic disorder and agoraphobia from social phobia. (7964668)
1994
49
The use of the reversible monoamine oxidase-A inhibitor brofaromine in social phobia complicated by panic disorder with or without agoraphobia. (8151007)
1994
50
Elective mutism as a variant of social phobia. (1342579)
1992

Genetic Variations for Social Phobia

Expression for genes affiliated with Social Phobia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Social Phobia

Search GEO for disease gene expression data for Social Phobia.

Pathways for genes affiliated with Social Phobia

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Social Phobia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Social Phobia according to GeneCards/GeneDecks:

(show top 50)    (show all 258)
idCompoundScoreTop Affiliating Genes
1amperozide459.8HTR3A, HTR1A, DRD2
2idazoxan459.7HTR1A, DRD2, MAOA
38-hydroxy-2-(di-n-propylamino)tetralin459.7HTR3A, HTR1A, SLC6A4
4methysergide45 29 1111.7HTR3A, CCK, HTR1A, MAOA
5benzodiazepine459.7HTR3A, MAOA, PTK7, CCK
6mianserin29 45 1111.7HTR1A, SLC6A4, MAOA, HTR3A
7sertraline45 29 50 11 2413.7HTR1A, SLC6A4, MAOA, HTR3A
8fluvoxamine45 50 1111.6SLC6A4, HTR1A, MAOA, HTR3A
9carbon-11459.6SLC6A4, MAOA, HTR1A
10maoa459.5HTR1A, MAOA, SLC6A4, DRD2
11m-chlorophenylpiperazine459.5SLC6A4, HTR3A, PRL, HTR1A
12mdma459.5SLC6A4, PRL, MAOA, HTR1A
13mcpp459.5SLC6A4, HTR1A, HTR3A, PRL
14nmda45 2910.5TACR1, MAOA, HTR1A
15pindolol45 29 1111.5PRL, SLC6A4, HTR3A, HTR1A
16ketanserin29 4510.5HTR1A, HTR3A, DRD2, SLC6A4
17p-chloroamphetamine459.5SLC6A4, HTR1A, MAOA
18buspirone45 29 1111.5HTR3A, HTR1A, DRD2, PRL
19ritanserin29 4510.5DRD2, HTR3A, HTR1A, PRL
20metoclopramide45 1110.4CCK, HTR3A, PRL, DRD2
21mhpg459.4PRL, MAOA, SLC6A4, NPY
22nemonapride50 45 2911.4PRL, DRD2, HTR1A
23ondansetron45 50 11 2412.4TACR1, HTR3A, HTR1A, CCK
24trimipramine50 45 1111.3PRL, SLC6A4, HTR1A, DRD2
25aripiprazole29 50 45 11 2413.3HTR3A, HTR1A, DRD2, PRL
26ziprasidone50 29 45 1112.3DRD2, HTR1A, HTR3A, PRL
27yohimbine45 29 2 1112.3HTR3A, NPY, HTR1A, DRD2
285-hydroxytryptophan459.2PRL, HTR3A, SLC6A4, HTR1A, PTK7
29amphetamine45 1110.2SLC6A4, MAOA, DRD2, NPY, CCK
30imipramine45 50 29 11 2413.2HTR3A, SLC6A4, TACR1, MAOA, HTR1A
31risperidone29 45 50 60 11 2414.1DRD2, SLC6A4, HTR1A, HTR3A, PRL
32fenfluramine29 45 1110.8CCK, SLC6A4, PRL, NPY, HTR3A, HTR1A
33clomipramine45 50 1110.8HTR3A, HTR1A, MAOA, TACR1, SLC6A4, PRL
34paroxetine45 50 29 1111.8MAOA, SLC6A4, TACR1, PRL, HTR3A, HTR1A
35octreotide45 60 29 1111.8NPY, CCK, TACR1, PRL, DRD2
36gaba458.7SLC6A4, DRD2, NPY, MAOA, PTK7, CCK
37epinephrine45 11 2410.6DRD2, NPY, PRL, MAOA, SLC6A4, PTK7
38clozapine45 29 50 1111.6HTR1A, PRL, TACR1, SLC6A4, DRD2, HTR3A
39cocaine45 119.6SLC6A4, PRL, DRD2, CCK, NPY
40citalopram50 45 11 2411.5MAOA, TACR1, SLC6A4, PTK7, PRL, HTR3A
41opiate458.5DRD2, PRL, CCK, TACR1, SLC6A4, NPY
42fluoxetine50 45 29 1111.4MAOA, HTR1A, HTR3A, DRD2, PRL, TACR1
436-hydroxydopamine458.4MAOA, SOD1, CAT, DRD2, NPY
44haloperidol45 29 2 50 1112.2DRD2, NPY, HTR3A, HTR1A, SLC6A4, TACR1
45levodopa45 119.1CAT, DRD2, MAOA, PRL, HTR1A, SOD1
46sodium nitroprusside458.0TACR1, NPY, SOD1, CAT, CCK
47acetylcholine45 50 29 11 2412.0HTR3A, HTR1A, DRD2, TACR1, CCK, NPY
485-hydroxytryptamine457.7SLC6A4, CCK, HTR1A, NPY, DRD2, PRL
49norepinephrine45 11 249.4PTK7, HTR1A, HTR3A, NPY, DRD2, PRL
50dopamine45 29 11 2410.4HTR1A, HTR3A, DRD2, PRL, MAOA, NPY

GO Terms for genes affiliated with Social Phobia

Sources:
16Gene Ontology
See all sources

Cellular components related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5DRD2, HTR3A, CCK
2integral to plasma membraneGO:0058878.1PTK7, SLC6A4, TACR1, DRD2, HTR3A, HTR1A

Biological processes related to Social Phobia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.1HTR1A, HTR3A
2vasoconstrictionGO:0423109.9SLC6A4, HTR1A
3sperm ejaculationGO:0427139.8SLC6A4, TACR1
4response to cocaineGO:0422209.7DRD2, HTR3A
5positive regulation of renal sodium excretionGO:0358159.7TACR1, DRD2
6associative learningGO:0083069.6TACR1, DRD2
7response to morphineGO:0432789.6TACR1, DRD2
8behaviorGO:0076109.6TACR1, MAOA, NPY
9response to estradiol stimulusGO:0323559.4PRL, TACR1, SLC6A4
10eating behaviorGO:0427559.4TACR1, CCK
11response to hypoxiaGO:0016669.1CAT, DRD2, SLC6A4
12response to ethanolGO:0454718.9TACR1, PRL, SOD1
13response to drugGO:0424938.7SOD1, DRD2, PRL, SLC6A4

Molecular functions related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.8NPY, CCK

Products for genes affiliated with Social Phobia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Social Phobia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet