MCID: SCL003
MIFTS: 48

Social Phobia malady

Mental diseases category

Summaries for Social Phobia

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Disease Ontology:9 A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards based summary: Social Phobia, also known as phobia, social, is related to anxiety disorder and personality disorder. An important gene associated with Social Phobia is MAOA (monoamine oxidase A), and among its related pathways are Monoamine Transport and Monoamine GPCRs. The compounds methysergide and benzodiazepine have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and testes, and related mouse phenotypes are integument and skeleton.

Aliases & Classifications for Social Phobia

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 25ICD10
See all sources

Social Phobia, Aliases & Descriptions:

Name: Social Phobia 9
Phobia, Social 60
 
Phobia Social 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:11257
ICD9CM27 300.23
NCIt38 C34927
SNOMED-CT55 25501002, 192395002
MeSH33 D010698
ICD1025 F40.1

Related Diseases for Social Phobia

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Diseases related to Social Phobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.7HTR3A, MAOA, SLC6A4
2personality disorder31.7MAOA, DRD2, SLC6A4
3generalized anxiety disorder31.6HTR1A, SLC6A4
4agoraphobia31.6PTK7, HTR1A, MAOA
5panic disorder31.3PTK7, CCK, HTR3A, HTR1A, SLC6A4
6premature ejaculation31.0HTR1A, SLC6A4
7obsessive-compulsive disorder30.9HTR3A, HTR1A, MAOA, DRD2, SLC6A4
8eating disorder30.9SLC6A4
9schizophrenia30.8PRL, DRD2, SLC6A4
10drug dependence30.8SLC6A4, DRD2, MAOA
11bipolar disorder30.8HTR1A, SLC6A4
12borderline personality disorder30.7SLC6A4, MAOA
13alcohol dependence30.3SLC6A4, NPY, DRD2, MAOA
14obesity30.1CCK, HTR1A, MAOA, DRD2, NPY
15mood disorder29.7TACR1, NPY, SLC6A4, DRD2, MAOA, HTR1A
16avoidant personality disorder10.9
17melancholia10.6MAOA
18mutism10.6
19biliary dyskinesia10.5CCK
20endogenous depression10.5MAOA
21pathological gambling10.5DRD2
22pervasive developmental disorder10.4SLC6A4
23body dysmorphic disorder10.4
24separation anxiety disorder10.4
25hypermethioninemia10.4SOD1
26motion sickness10.4HTR3A, HTR1A
27bulimia nervosa10.4CCK, SLC6A4
28gastroparesis10.3CCK, HTR3A
29dyspepsia10.3HTR3A, CCK
30neuroleptic malignant syndrome10.3DRD2, HTR1A
31amnestic disorder10.3HTR3A, HTR1A
32major depressive disorder and accelerated response to antidepressant drug treatment10.3HTR1A, SLC6A4
33restless legs syndrome10.3HTR3A, DRD2
34substance abuse10.3DRD2, SLC6A4
35phobia, specific10.3
36acne10.3
37strabismus10.3
38elective mutism10.3
39blindness10.3
40serotonin syndrome10.3MAOA, HTR1A, HTR3A
41substance dependence10.3DRD2, SLC6A4
42carcinoid syndrome10.3CCK, HTR3A, MAOA
43diabetic cataract10.3CAT
44ewing sarcoma10.3CCK, NPY
45constipation10.3CCK, HTR3A, SLC6A4
46irritable bowel syndrome10.2SLC6A4, HTR3A, CCK
47cocaine dependence10.2SLC6A4, DRD2
48chronic fatigue syndrome10.2HTR1A, MAOA, SLC6A4
49autonomic neuropathy10.2NPY, CCK
50alcohol abuse10.2DRD2, SLC6A4

Graphical network of the top 20 diseases related to Social Phobia:



Diseases related to social phobia

Symptoms for Social Phobia

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Drugs & Therapeutics for Social Phobia

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Drug clinical trials:

Search ClinicalTrials for Social Phobia

Search NIH Clinical Center for Social Phobia

Genetic Tests for Social Phobia

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Anatomical Context for Social Phobia

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MalaCards organs/tissues related to Social Phobia:

31
Brain, Amygdala, Testes, Cortex, Heart, Pituitary, Eye, Prefrontal cortex, Cingulate cortex, Hypothalamus

Animal Models for Social Phobia or affiliated genes

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MGI Mouse Phenotypes related to Social Phobia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3SLC6A4, TACR1, DRD2, HTR3A, PRL
2MP:00053907.8TACR1, DRD2, SOD1, PTK7, NPY
3MP:00053797.8SLC6A4, DRD2, CCK, PRL, HTR3A, SOD1
4MP:00053857.5PTK7, TACR1, DRD2, SLC6A4, MAOA, HTR1A
5MP:00107687.0CAT, SLC6A4, DRD2, HTR1A, HTR3A, SOD1
6MP:00053866.2SLC6A4, PTK7, SOD1, PRL, HTR1A, MAOA
7MP:00036316.0TACR1, SLC6A4, NPY, PTK7, DRD2, MAOA
8MP:00053765.7HTR1A, CCK, PRL, HTR3A, SLC6A4, NPY

Publications for Social Phobia

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Articles related to Social Phobia:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Behavioral treatment of social phobia in youth: Does parent education training improve the outcome? (25727679)
2015
2
The primary care diagnosis and management of social phobia and its relevance in the UK Armed Forces. (23691857)
2013
3
An investigator-blinded, randomized study to compare the efficacy of combined CBT for alcohol use disorders and social anxiety disorder versus CBT focused on alcohol alone in adults with comorbid disorders: the Combined Alcohol Social Phobia (CASP) trial protocol. (23895258)
2013
4
The SPAI-18, a brief version of the Social Phobia and Anxiety Inventory: Reliability and validity in clinically referred and non-referred samples. (23790687)
2013
5
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder. (22592057)
2012
6
Childhood history of behavioral inhibition and comorbidity status in 256 adults with social phobia. (20797795)
2011
7
Social phobia and other psychiatric problems in children with strabismus. (21784213)
2011
8
Social fear and social phobia types among community youth: differential clinical features and vulnerability factors. (20684833)
2011
9
A randomized pilot study of mindfulness-based cognitive therapy and group cognitive-behavioral therapy for young adults with social phobia. (20210911)
2010
10
Learning to change a way of being: an interpretative phenomenological perspective on cognitive therapy for social phobia. (20413253)
2010
11
Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia. (20227458)
2010
12
Pre-treatment patient variables as predictors of drop-out and treatment outcome in cognitive behavioural therapy for social phobia: A systematic review. (20055730)
2010
13
Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions. (20889651)
2010
14
Health anxiety and fear of fear in panic disorder and agoraphobia vs. social phobia: a prospective longitudinal study. (20143435)
2010
15
Social phobia in late-life: is it worth a diagnosis? (20597874)
2010
16
Randomized controlled trial of Internet cognitive behavioural treatment for social phobia with and without motivational enhancement strategies. (20932208)
2010
17
Further study of the psychometric qualities of a brief screening tool for social phobia (MINI-SPIN) applied to clinical and nonclinical samples. (20883433)
2010
18
Cognitive behavioral group therapy for social phobia with or without attention training: a controlled trial. (19059753)
2009
19
Dreams In Jungian Psychology: The use of Dreams as an Instrument For Research, Diagnosis and Treatment of Social Phobia. (22135511)
2009
20
Changes in post-event processing and metacognitions during cognitive behavioral group therapy for social phobia. (19250799)
2009
21
A demonstration of the efficacy of two of the components of cognitive therapy for social phobia. (19081225)
2009
22
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
23
Assessing post-event processing after social situations: a measure based on the cognitive model for social phobia. (18350392)
2008
24
Frequency of social phobia and psychometric properties of the Liebowitz social anxiety scale in Parkinson's disease. (18661550)
2008
25
A new proposal for the subtypes of social phobia in a sample of Spanish adolescents. (17367987)
2008
26
Screening for social phobia in medical in- and outpatients with the German version of the Social Phobia Inventory (SPIN). (17923381)
2008
27
Shyness 2: treating social phobia online: replication and extension. (18612863)
2008
28
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. (17974937)
2007
29
Group cohesion in cognitive-behavioral group therapy for social phobia. (16928359)
2007
30
Treatment of social phobia through pure self-help and therapist-augmented self-help. (17766766)
2007
31
The social phobia and anxiety inventory: problem of underlying medical conditions. (18232422)
2007
32
Specificity of autobiographical memory in social phobia and major depression. (17472199)
2007
33
Temperament and character dimensions in patients with social phobia: patterns of change following treatments? (17328961)
2007
34
Therapeutic factors of cognitive behavioral group treatment for social phobia. (16614524)
2006
35
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
36
Intensive cognitive behavioural group treatment for social phobia: a pilot study. (15844687)
2005
37
Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. (15860337)
2005
38
Comparing the prevalence rates of social phobia in a community according to ICD-10 and DSM-III-R. (16224610)
2005
39
Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia. (16129496)
2005
40
Emerging treatments for child and adolescent social phobia: a review. (16190791)
2005
41
EEG mapping in patients with social phobia. (15465293)
2004
42
Social phobia and avoidant personality disorder: one spectrum disorder? (15204221)
2004
43
Social Phobia in an Italian region: do Italian studies show lower frequencies than community surveys conducted in other European countries? (15488146)
2004
44
Genome-wide linkage scan for loci predisposing to social phobia: evidence for a chromosome 16 risk locus. (14702251)
2004
45
Childhood stress and symptoms of drug dependence in adolescence and early adulthood: social phobia as a mediator. (9990437)
1999
46
The observer perspective: biased imagery in social phobia, agoraphobia, and blood/injury phobia. (10402690)
1999
47
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)
1998
48
Moclobemide in the treatment of social phobia. (8923114)
1996
49
Is elective mutism a social phobia? (8407760)
1993
50
Avoidant personality disorder and the generalized subtype of social phobia. (1583226)
1992

Variations for Social Phobia

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Expression for genes affiliated with Social Phobia

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Search GEO for disease gene expression data for Social Phobia.

Pathways for genes affiliated with Social Phobia

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Pathways related to Social Phobia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity36
9.8SLC6A4, MAOA
2
Show member pathways
9.7DRD2, HTR1A
39.4MAOA, SOD1
49.2SLC6A4, MAOA, HTR1A, HTR3A
5
Show member pathways
Vitamin B12 Metabolism36
9.0SOD1, CAT
6
Show member pathways
9.0SOD1, CAT
79.0CAT, SOD1
8
Show member pathways
9.0CAT, SOD1
98.9NPY, HTR1A, SOD1
10
Show member pathways
8.8PRL, MAOA, DRD2, NPY
11
Show member pathways
8.8SLC6A4, DRD2, MAOA, HTR1A, HTR3A
128.8SOD1, MAOA, CAT
138.7HTR3A, HTR1A, MAOA, TACR1, SLC6A4
14
Show member pathways
7.9PRL, CCK, HTR1A, DRD2, TACR1, NPY
15
Show member pathways
7.9PRL, CCK, HTR1A, DRD2, TACR1, NPY

Compounds for genes affiliated with Social Phobia

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Compounds related to Social Phobia according to GeneCards Suite gene sharing:

(show top 50)    (show all 296)
idCompoundScoreTop Affiliating Genes
1methysergide43 28 1211.6CCK, HTR3A, HTR1A, MAOA
2benzodiazepine439.6PTK7, MAOA, HTR3A, CCK
3amperozide439.5DRD2, HTR1A, HTR3A
4mianserin43 28 1211.5HTR1A, HTR3A, SLC6A4, MAOA
5Serotonin249.5MAOA, SLC6A4, HTR1A, HTR3A
6sertraline43 28 49 24 1213.5HTR3A, SLC6A4, MAOA, HTR1A
7fluvoxamine43 49 1211.5HTR1A, MAOA, SLC6A4, HTR3A
88-hydroxy-2-(di-n-propylamino)tetralin439.5HTR3A, HTR1A, SLC6A4
9maoa439.4DRD2, MAOA, HTR1A, SLC6A4
10mdma439.3HTR1A, SLC6A4, MAOA, PRL
11m-chlorophenylpiperazine439.3HTR3A, HTR1A, SLC6A4, PRL
12mcpp439.3HTR1A, HTR3A, PRL, SLC6A4
13ketanserin43 2810.3SLC6A4, DRD2, HTR1A, HTR3A
14pindolol43 28 1211.3HTR3A, HTR1A, SLC6A4, PRL
15buspirone43 28 1211.3PRL, HTR3A, HTR1A, DRD2
16ritanserin43 2810.3HTR1A, DRD2, HTR3A, PRL
17mhpg439.2PRL, MAOA, NPY, SLC6A4
18metoclopramide43 49 1211.2HTR3A, CCK, PRL, DRD2
19trimipramine43 49 1211.2SLC6A4, DRD2, PRL, HTR1A
20idazoxan439.2MAOA, DRD2, HTR1A
21amphetamine43 49 1211.1CCK, SLC6A4, MAOA, DRD2, NPY
22ondansetron49 43 24 1212.1HTR3A, HTR1A, TACR1, SLC6A4, CCK
23aripiprazole28 43 49 24 1213.0PRL, DRD2, HTR1A, HTR3A
245-hydroxytryptophan439.0SLC6A4, HTR1A, HTR3A, PRL, PTK7
25imipramine43 28 49 24 1213.0HTR3A, HTR1A, MAOA, TACR1, SLC6A4
26yohimbine43 2 28 1212.0HTR3A, HTR1A, DRD2, NPY
27ziprasidone28 49 43 1212.0HTR3A, PRL, HTR1A, DRD2
28quetiapine43 49 28 24 1212.9HTR1A, SLC6A4, HTR3A, PRL, DRD2
29risperidone43 49 28 59 24 1213.9PRL, HTR3A, HTR1A, DRD2, SLC6A4
30olanzapine43 49 28 24 1212.9PRL, HTR3A, SLC6A4, DRD2, HTR1A
31octreotide43 59 28 1211.7DRD2, PRL, NPY, TACR1, CCK
32fenfluramine43 28 1210.6SLC6A4, NPY, HTR1A, HTR3A, CCK, PRL
33clomipramine43 49 1210.6PRL, HTR3A, HTR1A, MAOA, TACR1, SLC6A4
34paroxetine43 49 28 1211.6TACR1, MAOA, HTR1A, PRL, SLC6A4, HTR3A
35gaba438.5CCK, SLC6A4, NPY, DRD2, MAOA, HTR3A
36epinephrine43 24 1210.4PTK7, PRL, DRD2, MAOA, SLC6A4, NPY
37clozapine43 28 49 1211.4TACR1, SLC6A4, DRD2, HTR1A, HTR3A, PRL
38acetylcholine43 49 28 24 1212.3HTR3A, DRD2, HTR1A, TACR1, NPY, CCK
39opiate438.3TACR1, NPY, SLC6A4, DRD2, CCK, PRL
40cocaine43 129.3NPY, PRL, CCK, DRD2, SLC6A4
41nmda43 289.3SLC6A4, MAOA, HTR1A, DRD2, TACR1, NPY
426-hydroxydopamine438.3NPY, MAOA, CAT, DRD2, SOD1
43citalopram43 49 24 1211.3HTR3A, SLC6A4, TACR1, MAOA, HTR1A, PRL
44fluoxetine43 49 28 1211.2MAOA, HTR1A, HTR3A, PRL, DRD2, SLC6A4
45haloperidol43 49 28 2 1212.0SLC6A4, NPY, TACR1, DRD2, HTR1A, PRL
46sodium nitroprusside438.0SOD1, NPY, CAT, TACR1, CCK
47levodopa43 128.9HTR1A, PRL, MAOA, DRD2, SOD1, CAT
485-hydroxytryptamine437.4HTR3A, HTR1A, MAOA, DRD2, TACR1, NPY
49dopamine43 28 24 1210.1PTK7, SLC6A4, NPY, PRL, CCK, HTR3A
50norepinephrine43 24 129.1CCK, HTR3A, HTR1A, MAOA, DRD2, TACR1

GO Terms for genes affiliated with Social Phobia

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Cellular components related to Social Phobia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.4CCK, HTR3A, DRD2
2dendriteGO:00304259.3TACR1, DRD2, CCK
3integral component of plasma membraneGO:00058878.2DRD2, PTK7, HTR3A, HTR1A, SLC6A4, TACR1
4plasma membraneGO:00058866.8SLC6A4, SOD1, HTR3A, HTR1A, CAT, DRD2

Biological processes related to Social Phobia according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:000721010.1HTR3A, HTR1A
2vasoconstrictionGO:004231010.0HTR1A, SLC6A4
3behavioral fear responseGO:000166210.0CCK, HTR1A
4response to cocaineGO:004222010.0HTR3A, DRD2
5eating behaviorGO:00427559.9CCK, TACR1
6sperm ejaculationGO:00427139.9SLC6A4, TACR1
7positive regulation of renal sodium excretionGO:00358159.8TACR1, DRD2
8associative learningGO:00083069.8TACR1, DRD2
9response to morphineGO:00432789.8DRD2, TACR1
10response to nicotineGO:00350949.7TACR1, DRD2
11long-term memoryGO:00076169.6DRD2, TACR1
12cellular response to growth factor stimulusGO:00713639.6CAT, HTR3A
13feeding behaviorGO:00076319.5DRD2, NPY
14response to axon injuryGO:00486789.4SOD1, DRD2
15response to hypoxiaGO:00016669.4SLC6A4, DRD2, CAT
16response to amphetamineGO:00019759.2DRD2, SOD1
17regulation of multicellular organism growthGO:00400149.2SOD1, PRL
18response to ethanolGO:00454719.2TACR1, HTR3A, SOD1
19response to heatGO:00094088.8TACR1, SOD1

Molecular functions related to Social Phobia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00049939.8HTR1A, HTR3A
2neuropeptide hormone activityGO:00051849.6NPY, CCK
3protein homodimerization activityGO:00428037.9CAT, DRD2, SLC6A4, SOD1
4protein bindingGO:00055156.9HTR1A, PRL, SOD1, PTK7, DRD2, TACR1

Products for genes affiliated with Social Phobia

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Sources for Social Phobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet