Social Phobia malady

Disease Ontology: A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.⁶

MalaCards: Social Phobia, also known as phobic anxiety disorder, is related to panic disorder and phobia. An important gene associated with Social Phobia is WNT10A (wingless-type MMTV integration site family, member 10A), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Pathway_PA165980337. The drugs paroxetine and gabapentin and the compounds 2-methyl-5-ht and 8-hydroxy-2-(di-n-propylamino)tetralin have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala, and related mouse phenotypes are cardiovascular system and nervous system.

Wikipedia: Social phobia (better termed as social anxiety disorder) is distinguished by a fear of public...⁴⁴ more...

Aliases & Descriptions:

social phobia 6 phobic anxiety disorder 43

phobia, social 43 phobia social 32

Diseases related to social phobia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 212)

id	Related Disease	Score	Top Affiliating Genes
1	panic disorder	31.1	CCK, HTR1A, HTR3A, PTK7, SLC6A4
2	phobia	28.6	MBNL1, MAOA, CCK, HTR1A, HTR3A, CAT
3	obsessive-compulsive disorder	25.7	MAOA, CCK, HTR1A, HTR3A, CAT, DRD2
4	anxiety disorder	25.2	MAOA, CCK, HTR1A, HTR3A, DRD2, PTK7
5	cerebritis	24.0	MAOA, CCK, HTR1A, HTR3A, CAT, DRD2
6	blindness	23.6	MAOA, CCK, HTR1A, HTR3A, CAT, DRD2
7	cognitive disease	13.3	MAOA, HTR1A
8	generalized anxiety disorder	13.3	HTR1A, SLC6A4
9	bulimia nervosa	13.2	CCK, SLC6A4
10	endogenous depression	13.2	HTR1A, SLC6A4
11	leptin deficiency	13.2	CCK, NPY
12	amnestic disorder	13.2	HTR1A, HTR3A
13	agoraphobia	13.2	MAOA, HTR1A, PTK7
14	bipolar disorder	13.2	HTR1A, SLC6A4
15	biliary dyskinesia	13.2	CCK, SOD1
16	postcholecystectomy syndrome	13.2	CCK, SOD1
17	novelty seeking personality	13.1	MAOA, DRD2
18	subependymal giant cell astrocytoma	13.0	CCK, NPY
19	carcinoid syndrome	13.0	MAOA, CCK, HTR3A
20	labyrinthitis	13.0	HTR3A, NPY
21	motion sickness	13.0	HTR1A, HTR3A, TACR1
22	meningitis and encephalitis	12.9	CAT, SOD1
23	avascular necrosis of femoral head	12.9	CAT, SOD1
24	hypermethioninemia	12.9	CAT, SOD1
25	neuroleptic malignant syndrome	12.8	HTR1A, HTR3A, DRD2
26	digestive diseases	12.8	CAT, SOD1
27	personality disorder	12.7	MAOA, DRD2, SLC6A4
28	frontotemporal dementia	12.7	MAOA, SOD1, NPY
29	antisocial personality disorder	12.7	MAOA, DRD2, SLC6A4
30	pathological gambling	12.7	MAOA, DRD2, SLC6A4
31	manic-depressive illness	12.7	MAOA, DRD2, SLC6A4
32	sudden infant death syndrome	12.7	MAOA, HTR1A, HTR3A, SLC6A4
33	opiate dependence	12.7	MAOA, DRD2, SLC6A4
34	glycogen storage disease type ia	12.7	CAT, SOD1
35	substance dependence	12.7	MAOA, DRD2, SLC6A4
36	progressive supranuclear palsy	12.7	HTR1A, HTR3A, DRD2
37	growth mental deficiency syndrome of myhre	12.7	MAOA, DRD2, SLC6A4
38	attention deficit hyperactivity disorder	12.7	MAOA, DRD2, SLC6A4
39	major affective disorder	12.7	HTR3A, DRD2, SLC6A4
40	neuroendocrine tumor	12.7	CCK, DRD2, NPY
41	nicotine dependence	12.6	MAOA, DRD2, SLC6A4
42	diabetic cataract	12.6	CAT, SOD1
43	obstructive jaundice	12.6	CCK, CAT, SOD1
44	toxic encephalopathy	12.6	MAOA, CAT, SLC6A4
45	peptic ulcer	12.6	CCK, CAT, SOD1
46	conduct disorder	12.6	MAOA, DRD2, SLC6A4
47	aphthous stomatitis	12.6	CAT, SOD1, SLC6A4
48	melancholia	12.6	MAOA, PRL, SLC6A4
49	convulsions	12.5	HTR3A, CAT, SOD1
50	tetralogy of fallot	12.5	CAT, SOD1, NPY

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 gabapentin, gabapentin enacarbil, paroxetine, paroxetine hydrochloride

MalaCards organs/tissues related to social phobia:

²²

MGI Mouse Phenotypes related to social phobia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	7.8	SOD1, TACR1, PTK7, DRD2, HTR1A, MAOA
2	nervous system phenotype	MP:0003631	6.4	MAOA, SLC6A4, NPY, PRL, TACR1, PTK7
3	behavior/neurological phenotype	MP:0005386	6.3	SLC6A4, NPY, SOD1, PRL, TACR1, DRD2
4	homeostasis/metabolism phenotype	MP:0005376	5.5	SLC6A4, NPY, SOD1, PRL, TACR1, DRD2

Articles related to social phobia:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Antioxidant enzyme and malondialdehyde levels in patients with social phobia. (18339429)	Atmaca M.... Ustundag B.	2008	SOD1, CAT
2	Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo. (16038684)	Furmark T.... Fredrikson M.	2005	TACR1
3	Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. (15158011)	Furmark T.... Fredrikson M.	2004	SLC6A4
4	Neurobiology and pharmacotherapy of social phobia (15538306)	Aouizerate B.... Tignol J.	2004	DRD2, HTR1A, CCK
5	Effects of CCK-tetrapeptide in patients with social phobia and obsessive-compulsive disorder. (15390214)	Katzman M.A.... Bradwejn J.	2004	PTK7
6	Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with 11C McN 5652. (12457263)	Kent J.M.... Laruelle M.	2002	SLC6A4
7	A preliminary study of dopamine-mediated prolactin inhibition in generalised social phobia. (12140123)	Condren R.M.... Thakore J.H.	2002	DRD2, PRL
8	Social phobia: diagnosis, severity and implications for treatment. (10361959)	Montgomery S.A.	1999	MAOA
9	Genetic linkage to the serotonin transporter protein and 5HT2A receptor genes excluded in generalized social phobia. (9925179)	Stein M.B.... Kennedy J.L.	1998	SLC6A4
10	Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)	Hollander E.... Simeon D.	1998	PRL
11	Placebo-controlled trial of moclobemide in social phobia. (9534836)	Schneier F.R.... Liebowitz M.R.	1998	MAOA
12	Effects of the 5-HT3 antagonist, ondansetron, on the behavioral and physiological effects of pentagastrin in patients with panic disorder and social phobia. (9397424)	McCann U.D.... Post R.M.	1997	HTR3A, CCK
13	Plasma neuropeptide Y in anxiety disorders: findings in panic disorder and social phobia. (8930023)	Stein M.B.... Asmundson G.J.	1996	NPY
14	Moclobemide in the treatment of social phobia. (8923114)	Nutt D.... Montgomery S.A.	1996	MAOA
15	The pharmacotherapy of social phobia. (8923113)	Pollack M.H.... Gould R.A.	1996	MAOA
16	Social phobia: the clinical efficacy and tolerability of the monoamine oxidase -A and serotonin uptake inhibitor brofaromine. A double-blind placebo-controlled study. (8619339)	FahlAcn T.... Pauli U.	1995	MAOA
17	3H]paroxetine binding to platelets of patients with social phobia: comparison to patients with panic disorder and healthy volunteers. (7711158)	Stein M.B.... Hazen A.L.	1995	SLC6A4
18	Neuroendocrine responsivity to monoaminergic system p robes in generalized social phobia. (9160577)	Tancer M.E.... Golden R.N.	1994-1995	PRL
19	Reversible monoamine oxidase-A inhibitors in social phobia. (8313403)	Liebowitz M.R.... Feerick J.	1993	MAOA

Genes related to social phobia according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	WNT10A	wingless-type MMTV integration site family, member 10A	11.0
2	MAOA	monoamine oxidase A	11.0	Publications
3	PTK7	PTK7 protein tyrosine kinase 7	11.0	Publications
4	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
5	TACR1	tachykinin receptor 1	11.0	Publications
6	NPY	neuropeptide Y	11.0	Publications
7	MBNL1	muscleblind-like splicing regulator 1	11.0
8	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
9	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
10	CCK	cholecystokinin	11.0	Publications
11	CAT	catalase	11.0	Publications
12	DRD2	dopamine receptor D2	11.0	Publications
13	PRL	prolactin	11.0	Publications
14	SOD1	superoxide dismutase 1, soluble	11.0	Publications

Pathways related to social phobia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.6	MAOA, HTR1A, SLC6A4
2	Pathway_PA16598033734	9.4	SOD1, CAT
3	Oxidative Stress Pathway (Erythrocyte)34	9.3	SOD1, CAT
4	Oxidative Stress Pathway (Erythrocyte)34	9.1	SOD1, CAT
5	Neuroactive ligand-receptor interaction20	8.3	HTR1A, DRD2, TACR1, PRL

Compounds related to social phobia according to GeneDecks:

(show top 50)    (show all 232)

id	Compound	Score	Top Affiliating Genes
1	2-methyl-5-ht32	9.6	HTR1A, TACR1, HTR3A
2	8-hydroxy-2-(di-n-propylamino)tetralin32	9.6	HTR3A, SLC6A4, HTR1A
3	mianserin32 9 9	11.5	MAOA, HTR1A, HTR3A, SLC6A4
4	p-chloroamphetamine32	9.5	MAOA, HTR1A, SLC6A4
5	sertraline32 34 9 18 9	13.5	MAOA, HTR3A, SLC6A4, HTR1A
6	fluvoxamine32 34 9 9	12.5	MAOA, SLC6A4, HTR1A, HTR3A
7	carbon-1132	9.4	MAOA, SLC6A4, HTR1A
8	benzodiazepine32	9.4	MAOA, CCK, HTR3A, PTK7
9	yohimbine32 9 9	11.4	DRD2, HTR1A, NPY
10	idazoxan32	9.4	MAOA, HTR1A, DRD2
11	methysergide32 9 9	11.4	MAOA, CCK, HTR3A, HTR1A
12	amperozide32	9.3	HTR1A, DRD2, HTR3A
13	maoa32	9.2	MAOA, HTR1A, SLC6A4, DRD2
14	imipramine32 34 9 18 9	13.2	MAOA, SLC6A4, TACR1, HTR1A, HTR3A
15	ondansetron32 9 18 9	12.2	HTR3A, CCK, TACR1, HTR1A
16	mhpg32	9.2	SLC6A4, NPY, MAOA, PRL
17	ketanserin32	9.2	SLC6A4, DRD2, HTR3A, HTR1A
18	mdma32	9.1	HTR1A, PRL, SLC6A4, MAOA
19	m-chlorophenylpiperazine32	9.0	HTR1A, SLC6A4, PRL, HTR3A
20	mcpp32	9.0	HTR3A, HTR1A, SLC6A4, PRL
21	pindolol32 9 9	11.0	HTR1A, SLC6A4, PRL, HTR3A
22	nemonapride32	8.9	PRL, HTR1A, DRD2
23	amphetamine32 9 9	10.9	NPY, SLC6A4, CCK, MAOA, DRD2
24	spiperone32	8.8	HTR3A, DRD2, HTR1A
25	5-hydroxytryptophan32	8.7	HTR1A, HTR3A, PRL, SLC6A4, PTK7
26	trimipramine32 34 9 9	11.7	HTR1A, DRD2, PRL, SLC6A4
27	ritanserin32	8.7	PRL, DRD2, HTR3A, HTR1A
28	buspirone32 9 9	10.6	DRD2, PRL, HTR1A, HTR3A
29	6-hydroxydopamine32	8.6	MAOA, SOD1, NPY, CAT, DRD2
30	metoclopramide32 9 9	10.5	CCK, PRL, HTR3A, DRD2
31	aripiprazole32 34 9 18 9	12.5	DRD2, HTR1A, PRL, HTR3A
32	clomipramine32 34 9 9	11.5	HTR1A, HTR3A, PRL, MAOA, SLC6A4, TACR1
33	paroxetine32 34 9 9	11.5	HTR1A, PRL, HTR3A, MAOA, SLC6A4, TACR1
34	sodium nitroprusside32	8.4	CCK, CAT, TACR1, SOD1, NPY
35	risperidone32 34 9 18 9	12.4	HTR3A, PRL, HTR1A, SLC6A4, DRD2
36	ziprasidone32 9 9	10.4	HTR3A, HTR1A, PRL, DRD2
37	gaba32 42	9.3	CCK, MAOA, HTR3A, DRD2, NPY, PTK7
38	octreotide32 42 9 9	11.3	CCK, DRD2, TACR1, PRL, NPY
39	nmda32 42	9.3	MAOA, DRD2, TACR1, NPY, SLC6A4, HTR1A
40	fenfluramine32 9 9	10.3	NPY, SLC6A4, HTR1A, PRL, HTR3A, CCK
41	citalopram32 34 9 18 9	12.2	PRL, PTK7, HTR3A, TACR1, HTR1A, MAOA
42	epinephrine32 9 18 9	11.1	NPY, PTK7, DRD2, PRL, SLC6A4, MAOA
43	opiate32	8.1	CCK, PRL, NPY, SLC6A4, TACR1, DRD2
44	clozapine32 34 9 9	11.1	DRD2, HTR1A, HTR3A, TACR1, PRL, SLC6A4
45	fluoxetine32 34 9 9	10.9	SLC6A4, TACR1, DRD2, MAOA, HTR1A, HTR3A
46	haloperidol32 34 9 9	10.8	HTR1A, DRD2, NPY, TACR1, HTR3A, PRL
47	levodopa32 9 9	9.7	DRD2, MAOA, PRL, HTR1A, SOD1, CAT
48	5-hydroxytryptamine32	7.1	DRD2, CCK, HTR3A, TACR1, PRL, NPY
49	norepinephrine32 9 18 9	9.8	TACR1, PTK7, PRL, HTR3A, HTR1A, CCK
50	dopamine32 9 18 9	9.8	SLC6A4, TACR1, CCK, NPY, PRL, PTK7

Cellular components related to social phobia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon hillock	GO:043203	9.3	CCK, HTR1A
2	integral to plasma membrane	GO:005887	8.2	HTR1A, HTR3A, DRD2, PTK7, TACR1, SLC6A4

Biological processes related to social phobia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sperm ejaculation	GO:042713	9.8	SLC6A4, TACR1
2	associative learning	GO:008306	9.6	DRD2, TACR1
3	positive regulation of renal sodium excretion	GO:035815	9.3	DRD2, TACR1
4	behavior	GO:007610	9.2	MAOA, HTR1A, TACR1, NPY

Molecular functions related to social phobia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serotonin receptor activity	GO:004993	9.7	HTR1A, HTR3A
2	serotonin binding	GO:051378	9.1	MAOA, HTR1A, HTR3A