MCID: SCL003
MIFTS: 57

Social Phobia malady

Neuronal diseases category

Summaries for Social Phobia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards: Social Phobia, also known as phobic anxiety disorder, is related to personality disorder and anxiety disorder. An important gene associated with Social Phobia is MAOA (monoamine oxidase A), and among its related pathways are superoxide radicals degradation and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs gabapentin and paroxetine and the compounds amperozide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and testes, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Aliases & Classifications for Social Phobia

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

social phobia 8
phobic anxiety disorder 60
phobia, social 60
phobia social 44


External Ids:

Disease Ontology8 DOID:11257
MeSH34 D010698
ICD9CM27 300.23
SNOMED-CT56 192395002, 25501002
NCIt39 C34927
ICD1025 F40.1

Related Diseases for Social Phobia

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Social Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder31.3SLC6A4, MAOA, DRD2
2anxiety disorder31.2HTR3A, MAOA, SLC6A4
3panic disorder31.2CCK, HTR1A, HTR3A, SLC6A4, PTK7
4agoraphobia31.1PTK7, MAOA, HTR1A
5generalized anxiety disorder31.0HTR1A, SLC6A4
6obsessive-compulsive disorder30.8HTR1A, HTR3A, DRD2, MAOA, SLC6A4
7premature ejaculation30.4HTR1A, SLC6A4
8bipolar disorder30.3HTR1A, SLC6A4
9drug dependence30.3DRD2, MAOA, SLC6A4
10mood disorder30.3HTR1A, HTR3A, NPY, DRD2, MAOA, TACR1
11parkinson's disease30.3CAT, SOD1, HTR1A, HTR3A, DRD2, MAOA
12schizophrenia30.3CCK, HTR1A, HTR3A, NPY, DRD2, PRL
13borderline personality disorder30.1SLC6A4, MAOA
14attention deficit hyperactivity disorder30.1SLC6A4, MAOA, DRD2
15alcohol dependence30.1SLC6A4, MAOA, NPY, DRD2
16eating disorder30.1SLC6A4, NPY, HTR3A, HTR1A, CCK
17avoidant personality disorder10.8
18specific phobia10.7
19phobic disorder10.5
20mutism10.5
21separation anxiety disorder10.5
22body dysmorphic disorder10.3
23major depressive disorder10.3
24acne10.3
25strabismus10.3
26atypical depressive disorder10.1
27cerebritis10.1
28dependent personality disorder10.1
29animal phobia10.1
30delusional disorder10.1
31impulse control disorder10.1
32paraphilia disorder10.1
33physical disorder10.1
34sexual disorder10.1
35withdrawal disorder10.1
36melancholia10.0MAOA
37diarrhea10.0HTR3A
38alexithymia10.0WNT10A
39duodenal ulcer10.0CCK
40cluster headache10.0HTR3A
41cholecystitis10.0CCK
42heroin dependence10.0DRD2
43biliary dyskinesia10.0CCK
44pathological gambling10.0DRD2
45peptic ulcer10.0CCK
46glucose intolerance10.0NPY
47complex regional pain syndrome10.0TACR1
48dyspepsia10.0HTR3A, CCK
49varicocele10.0PRL
50autistic disorder10.0SLC6A4

Graphical network of the top 20 diseases related to Social Phobia:



Diseases related to social phobia

Clinical Features for Social Phobia

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Drugs & Therapeutics for Social Phobia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Social Phobia

Drug clinical trials:

Search ClinicalTrials for Social Phobia

Search NIH Clinical Center for Social Phobia

Search CenterWatch for Social Phobia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Social Phobia

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Anatomical Context for Social Phobia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Social Phobia:

32
Brain, Amygdala, Testes, Cortex, Pituitary, Heart, Hypothalamus, Cingulate cortex, Prefrontal cortex, Eye

Animal Models for Social Phobia or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Social Phobia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2SLC6A4, DRD2, HTR3A, CCK
2MP:00053857.3SOD1, HTR1A, DRD2, MAOA, TACR1, SLC6A4
3MP:00053866.3NPY, HTR3A, HTR1A, SOD1, DRD2, PRL
4MP:00036316.2PTK7, CCK, SOD1, HTR1A, HTR3A, NPY
5MP:00053765.8HTR1A, SOD1, CAT, CCK, HTR3A, NPY

Publications for Social Phobia

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Sources:
50PubMed
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Articles related to Social Phobia:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Assessing Social Anxiety in African American Youth using the Social Phobia and Anxiety Inventory for Children. (23872906)
2013
2
Visual search attentional bias modification reduced social phobia in adolescents. (24361543)
2013
3
The Relevance of Age of Onset to the Psychopathology of Social Phobia. (23935239)
2013
4
A randomized trial of attention training for generalized social phobia: does attention training change social behavior? (24094791)
2013
5
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder. (22592057)
2012
6
The association between online gaming, social phobia, and depression: an internet survey. (22839747)
2012
7
Social phobia and social anxiety disorder: effect of disorder name on recommendation for treatment. (22549213)
2012
8
Social phobia in Brazilian university students: prevalence, under-recognition and academic impairment in women. (22018945)
2012
9
Assessing therapeutic competence in cognitive therapy for social phobia: psychometric properties of the cognitive therapy competence scale for social phobia (CTCS-SP). (22047669)
2012
10
Childhood history of behavioral inhibition and comorbidity status in 256 adults with social phobia. (20797795)
2011
11
Social phobia and other psychiatric problems in children with strabismus. (21784213)
2011
12
Further development and validation of the Unhelpful Thoughts and Beliefs About Stuttering (UTBAS) scales: relationship to anxiety and social phobia among adults who stutter. (21575070)
2011
13
Nosological status of social phobia: contrasting classical and recent literature. (20966756)
2011
14
Is there any influence of personality disorder on the short term intensive group cognitive behavioral therapy of social phobia? (21475384)
2011
15
Do pharmacological and behavioral interventions differentially affect treatment outcome for children with social phobia? (21586501)
2011
16
Social skills deficits and vocal characteristics of children with social phobia or Asperger's disorder: a comparative study. (21399935)
2011
17
Social phobia in late-life: is it worth a diagnosis? (20597874)
2010
18
Gaze avoidance in social phobia: objective measure and correlates. (19863948)
2010
19
Characteristics and predictors of social phobia course in a longitudinal study of primary-care patients. (20186979)
2010
20
Factors affecting treatment efficacy in social phobia: the use of video feedback and individual vs. group formats. (18599263)
2009
21
High-frequency heart rate variability and cortico-striatal activity in men and women with social phobia. (19505585)
2009
22
Economic costs of social phobia: a population-based study. (19012968)
2009
23
Does social phobia remain the 'Ugly Duckling' of anxiety disorders? (20098821)
2009
24
Social phobia in Nigerian university students: prevalence, correlates and co-morbidity. (18979054)
2009
25
Assessing post-event processing after social situations: a measure based on the cognitive model for social phobia. (18350392)
2008
26
Shyness 1: distance treatment of social phobia over the Internet. (18612862)
2008
27
Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication? (17161000)
2008
28
Temperament and character dimensions in patients with social phobia: patterns of change following treatments? (17328961)
2007
29
Psychometric evaluation of the mini-social phobia inventory (Mini-SPIN) in a treatment-seeking sample. (17099878)
2007
30
Effectiveness of cognitive behavioural group therapy for social phobia in a community clinic: a benchmarking study. (17826734)
2007
31
Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. (17097275)
2007
32
Sudden gains during therapy of social phobia. (16881776)
2006
33
Mental representation of observable attributes in people with social phobia. (16563308)
2006
34
Associations in the longitudinal course of body dysmorphic disorder with major depression, obsessive-compulsive disorder, and social phobia. (16309706)
2006
35
Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. (16256956)
2006
36
Are we overpathologizing the socially anxious? Social phobia from a harmful dysfunction perspective. (15999945)
2005
37
Use of a religious hymn in remission of symptoms of social phobia (social anxiety disorder): a case study. (15941117)
2005
38
Virtual reality therapy versus cognitive behavior therapy for social phobia: a preliminary controlled study. (15738695)
2005
39
Results of a naturalistic longitudinal study of benzodiazepine and SSRI use in the treatment of generalized anxiety disorder and social phobia. (16094662)
2005
40
Social phobia and avoidant personality disorder: one spectrum disorder? (15204221)
2004
41
Cognitive causes of social phobia: a critical appraisal. (15245829)
2004
42
Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. (15158011)
2004
43
Face to face: visual scanpath evidence for abnormal processing of facial expressions in social phobia. (15261704)
2004
44
Selective attention to angry faces in clinical social phobia. (14992669)
2004
45
Public and private heart rate feedback in social phobia: a manipulation of anxiety visibility. (15224627)
2004
46
Virtual reality exposure in the treatment of social phobia. (15295148)
2004
47
Generalized social phobia versus avoidant personality disorder: differences in psychopathology, personality traits, and social and occupational functioning. (11043888)
2000
48
Treatment of Social Phobia: Potential Mediators and Moderators. (16799697)
2000
49
Reversible monoamine oxidase-A inhibitors in social phobia. (8313403)
1993
50
Use of medical services and treatment for panic disorder with agoraphobia and for social phobia. (1525731)
1992

Genetic Variations for Social Phobia

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Expression for genes affiliated with Social Phobia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Social Phobia

Search GEO for disease gene expression data for Social Phobia.

Pathways for genes affiliated with Social Phobia

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 29KEGG
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Compounds for genes affiliated with Social Phobia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Social Phobia according to GeneCards/GeneDecks:

(show top 50)    (show all 258)
idCompoundScoreTop Affiliating Genes
1amperozide449.8HTR3A, HTR1A, DRD2
2idazoxan449.7HTR1A, DRD2, MAOA
38-hydroxy-2-(di-n-propylamino)tetralin449.7HTR3A, HTR1A, SLC6A4
4methysergide44 28 1111.7HTR3A, CCK, HTR1A, MAOA
5benzodiazepine449.7HTR3A, MAOA, PTK7, CCK
6mianserin28 44 1111.7HTR1A, SLC6A4, MAOA, HTR3A
7sertraline44 28 49 11 2413.7HTR1A, SLC6A4, MAOA, HTR3A
8fluvoxamine44 49 1111.6SLC6A4, HTR1A, MAOA, HTR3A
9carbon-11449.6SLC6A4, MAOA, HTR1A
10maoa449.5HTR1A, MAOA, SLC6A4, DRD2
11m-chlorophenylpiperazine449.5SLC6A4, HTR3A, PRL, HTR1A
12mdma449.5SLC6A4, PRL, MAOA, HTR1A
13mcpp449.5SLC6A4, HTR1A, HTR3A, PRL
14nmda44 2810.5TACR1, MAOA, HTR1A
15pindolol44 28 1111.5PRL, SLC6A4, HTR3A, HTR1A
16ketanserin28 4410.5HTR1A, HTR3A, DRD2, SLC6A4
17p-chloroamphetamine449.5SLC6A4, HTR1A, MAOA
18buspirone44 28 1111.5HTR3A, HTR1A, DRD2, PRL
19ritanserin28 4410.5DRD2, HTR3A, HTR1A, PRL
20metoclopramide44 1110.4CCK, HTR3A, PRL, DRD2
21mhpg449.4PRL, MAOA, SLC6A4, NPY
22nemonapride49 44 2811.4PRL, DRD2, HTR1A
23ondansetron44 49 11 2412.4TACR1, HTR3A, HTR1A, CCK
24trimipramine49 44 1111.3PRL, SLC6A4, HTR1A, DRD2
25aripiprazole28 49 44 11 2413.3HTR3A, HTR1A, DRD2, PRL
26ziprasidone49 28 44 1112.3DRD2, HTR1A, HTR3A, PRL
27yohimbine44 28 2 1112.3HTR3A, NPY, HTR1A, DRD2
285-hydroxytryptophan449.2PRL, HTR3A, SLC6A4, HTR1A, PTK7
29amphetamine44 1110.2SLC6A4, MAOA, DRD2, NPY, CCK
30imipramine44 49 28 11 2413.2HTR3A, SLC6A4, TACR1, MAOA, HTR1A
31risperidone28 44 49 59 11 2414.1DRD2, SLC6A4, HTR1A, HTR3A, PRL
32fenfluramine28 44 1110.8CCK, SLC6A4, PRL, NPY, HTR3A, HTR1A
33clomipramine44 49 1110.8HTR3A, HTR1A, MAOA, TACR1, SLC6A4, PRL
34paroxetine44 49 28 1111.8MAOA, SLC6A4, TACR1, PRL, HTR3A, HTR1A
35octreotide44 59 28 1111.8NPY, CCK, TACR1, PRL, DRD2
36gaba448.7SLC6A4, DRD2, NPY, MAOA, PTK7, CCK
37epinephrine44 11 2410.6DRD2, NPY, PRL, MAOA, SLC6A4, PTK7
38clozapine44 28 49 1111.6HTR1A, PRL, TACR1, SLC6A4, DRD2, HTR3A
39cocaine44 119.6SLC6A4, PRL, DRD2, CCK, NPY
40citalopram49 44 11 2411.5MAOA, TACR1, SLC6A4, PTK7, PRL, HTR3A
41opiate448.5DRD2, PRL, CCK, TACR1, SLC6A4, NPY
42fluoxetine49 44 28 1111.4MAOA, HTR1A, HTR3A, DRD2, PRL, TACR1
436-hydroxydopamine448.4MAOA, SOD1, CAT, DRD2, NPY
44haloperidol44 28 2 49 1112.2DRD2, NPY, HTR3A, HTR1A, SLC6A4, TACR1
45levodopa44 119.1CAT, DRD2, MAOA, PRL, HTR1A, SOD1
46sodium nitroprusside448.0TACR1, NPY, SOD1, CAT, CCK
47acetylcholine44 49 28 11 2412.0HTR3A, HTR1A, DRD2, TACR1, CCK, NPY
485-hydroxytryptamine447.7SLC6A4, CCK, HTR1A, NPY, DRD2, PRL
49norepinephrine44 11 249.4PTK7, HTR1A, HTR3A, NPY, DRD2, PRL
50dopamine44 28 11 2410.4HTR1A, HTR3A, DRD2, PRL, MAOA, NPY

GO Terms for genes affiliated with Social Phobia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5DRD2, HTR3A, CCK
2integral to plasma membraneGO:0058878.1PTK7, SLC6A4, TACR1, DRD2, HTR3A, HTR1A

Biological processes related to Social Phobia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.1HTR1A, HTR3A
2vasoconstrictionGO:0423109.9SLC6A4, HTR1A
3sperm ejaculationGO:0427139.8SLC6A4, TACR1
4response to cocaineGO:0422209.7DRD2, HTR3A
5positive regulation of renal sodium excretionGO:0358159.7TACR1, DRD2
6associative learningGO:0083069.6TACR1, DRD2
7response to morphineGO:0432789.6TACR1, DRD2
8behaviorGO:0076109.6TACR1, MAOA, NPY
9response to estradiol stimulusGO:0323559.4PRL, TACR1, SLC6A4
10eating behaviorGO:0427559.4TACR1, CCK
11response to hypoxiaGO:0016669.1CAT, DRD2, SLC6A4
12response to ethanolGO:0454718.9TACR1, PRL, SOD1
13response to drugGO:0424938.7SOD1, DRD2, PRL, SLC6A4

Molecular functions related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.8NPY, CCK

Products for genes affiliated with Social Phobia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Social Phobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet