MCID: SCL003
MIFTS: 57

Social Phobia malady

Neuronal diseases category

Summaries for Social Phobia

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards: Social Phobia, also known as phobic anxiety disorder, is related to personality disorder and anxiety disorder. An important gene associated with Social Phobia is MAOA (monoamine oxidase A), and among its related pathways are superoxide radicals degradation and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs gabapentin and gabapentin enacarbil and the compounds amperozide and idazoxan have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and testes, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Aliases & Classifications for Social Phobia

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

social phobia 8
phobic anxiety disorder 60
phobia, social 60
phobia social 44


External Ids:

Disease Ontology8 DOID:11257
MeSH34 D010698
ICD9CM27 300.23
SNOMED-CT56 192395002, 25501002
NCIt39 C34927
ICD1025 F40.1

Related Diseases for Social Phobia

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Social Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder31.3SLC6A4, MAOA, DRD2
2anxiety disorder31.2HTR3A, MAOA, SLC6A4
3panic disorder31.2CCK, HTR1A, HTR3A, SLC6A4, PTK7
4agoraphobia31.1PTK7, MAOA, HTR1A
5generalized anxiety disorder31.0HTR1A, SLC6A4
6obsessive-compulsive disorder30.8HTR1A, HTR3A, DRD2, MAOA, SLC6A4
7premature ejaculation30.4HTR1A, SLC6A4
8bipolar disorder30.3HTR1A, SLC6A4
9drug dependence30.3DRD2, MAOA, SLC6A4
10mood disorder30.3HTR1A, HTR3A, NPY, DRD2, MAOA, TACR1
11parkinson's disease30.3CAT, SOD1, HTR1A, HTR3A, DRD2, MAOA
12schizophrenia30.3CCK, HTR1A, HTR3A, NPY, DRD2, PRL
13borderline personality disorder30.1SLC6A4, MAOA
14attention deficit hyperactivity disorder30.1SLC6A4, MAOA, DRD2
15alcohol dependence30.1SLC6A4, MAOA, NPY, DRD2
16eating disorder30.1SLC6A4, NPY, HTR3A, HTR1A, CCK
17avoidant personality disorder10.8
18specific phobia10.7
19phobic disorder10.5
20mutism10.5
21separation anxiety disorder10.5
22body dysmorphic disorder10.3
23major depressive disorder10.3
24acne10.3
25strabismus10.3
26atypical depressive disorder10.1
27cerebritis10.1
28dependent personality disorder10.1
29animal phobia10.1
30delusional disorder10.1
31impulse control disorder10.1
32paraphilia disorder10.1
33physical disorder10.1
34sexual disorder10.1
35withdrawal disorder10.1
36melancholia10.0MAOA
37diarrhea10.0HTR3A
38alexithymia10.0WNT10A
39duodenal ulcer10.0CCK
40cluster headache10.0HTR3A
41cholecystitis10.0CCK
42heroin dependence10.0DRD2
43biliary dyskinesia10.0CCK
44pathological gambling10.0DRD2
45peptic ulcer10.0CCK
46glucose intolerance10.0NPY
47complex regional pain syndrome10.0TACR1
48dyspepsia10.0HTR3A, CCK
49varicocele10.0PRL
50autistic disorder10.0SLC6A4

Graphical network of the top 20 diseases related to Social Phobia:



Diseases related to social phobia

Clinical Features for Social Phobia

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Drugs & Therapeutics for Social Phobia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Social Phobia

Drug clinical trials:

Search ClinicalTrials for Social Phobia

Search NIH Clinical Center for Social Phobia

Search CenterWatch for Social Phobia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Social Phobia

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Anatomical Context for Social Phobia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Social Phobia:

32
Brain, Amygdala, Testes, Cortex, Pituitary, Heart, Hypothalamus, Eye, Prefrontal cortex, Cingulate cortex

Animal Models for Social Phobia or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Social Phobia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2SLC6A4, DRD2, HTR3A, CCK
2MP:00053857.3SOD1, HTR1A, DRD2, MAOA, TACR1, SLC6A4
3MP:00053866.3NPY, HTR3A, HTR1A, SOD1, DRD2, PRL
4MP:00036316.2PTK7, CCK, SOD1, HTR1A, HTR3A, NPY
5MP:00053765.8HTR1A, SOD1, CAT, CCK, HTR3A, NPY

Publications for Social Phobia

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Sources:
50PubMed
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Articles related to Social Phobia:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
2
Aberrant reward center response to partner reputation during a social exchange game in generalized social phobia. (23576237)
2013
3
Peer victimization and social phobia: a follow-up study among adolescents. (23052422)
2013
4
Group climate as predictor of short- and long-term outcome in group therapy for social phobia. (23734921)
2013
5
Measurement invariance of the Social Phobia and Anxiety Inventory. (23247204)
2013
6
Cortisol levels in response to starting school in children at increased risk for social phobia. (21852051)
2012
7
Attention training toward and away from threat in social phobia: effects on subjective, behavioral, and physiological measures of anxiety. (22055280)
2012
8
Social fear and social phobia types among community youth: differential clinical features and vulnerability factors. (20684833)
2011
9
How does attention training work in social phobia: disengagement from threat or re-engagement to non-threat? (21907539)
2011
10
A prospective examination of predictors of post-event processing following videotaped exposures in group cognitive behavioural therapy for individuals with social phobia. (21330099)
2011
11
Does engagement with exposure yield better outcomes? Components of presence as a predictor of treatment response for virtual reality exposure therapy for social phobia. (21515027)
2011
12
Intensive group cognitive therapy and individual cognitive therapy for social phobia: sustained improvement at 5-year follow-up. (21763101)
2011
13
Pre-treatment patient variables as predictors of drop-out and treatment outcome in cognitive behavioural therapy for social phobia: A systematic review. (20055730)
2010
14
Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions. (20889651)
2010
15
Evaluation of the psychometric properties of the Social Phobia Inventory in university students. (20965310)
2010
16
Social skills and social phobia: an investigation of DSM-IV subtypes. (20637452)
2010
17
The Social Phobia Inventory: screening and cross-cultural validation in Spanish adolescents. (20977044)
2010
18
The time-course of attention to emotional faces in social phobia. (19781689)
2010
19
Cognitive mediation of clinical improvement after intensive exposure therapy of agoraphobia and social phobia. (20037922)
2010
20
Recognition of irrationality of fear and the diagnosis of social anxiety disorder and specific phobia in adults: implications for criteria revision in DSM-5. (20577989)
2010
21
SPINning factors: factor analytic evaluation of the Social Phobia Inventory in clinical and nonclinical undergraduate samples. (19818582)
2010
22
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
23
Cognitive behavioral therapy in the treatment of social phobia. (21234166)
2009
24
Associations between peer victimization, self-reported depression and social phobia among adolescents: the role of comorbidity. (18191998)
2009
25
Change processes in residential cognitive and interpersonal psychotherapy for social phobia: a process-outcome study. (19187813)
2009
26
Cognitive therapy for depressed adults with comorbid social phobia. (18804285)
2009
27
Social phobia: maintenance models and main components of CBT. (20635773)
2009
28
Social phobia: epidemiology and health care. (19935488)
2009
29
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (17898336)
2007
30
The effects of maternal social phobia on mother-infant interactions and infant social responsiveness. (17244269)
2007
31
Social phobia is associated with suicide attempt history in bipolar inpatients. (17988361)
2007
32
Subtypes of social phobia: are they of any use? (16806802)
2007
33
Treatment attrition during group therapy for social phobia. (16621439)
2006
34
The Tridimensional Personality Questionnaire: changes during psychological treatment of social phobia. (15935382)
2006
35
Parental assessment of childhood social phobia: psychometric properties of the social phobia and anxiety inventory for children-parent report. (17007605)
2006
36
Autobiographical memories prompted by automatic thoughts in panic disorder and social phobia. (16952896)
2006
37
Does co-occurring social phobia interfere with alcoholism treatment adherence and relapse? (17084794)
2006
38
Intensive cognitive behavioural group treatment for social phobia: a pilot study. (15844687)
2005
39
Comorbid PTSD and social phobia in a treatment-seeking population: an exploratory study. (15684911)
2005
40
Reliability of the Social Phobia and Anxiety Inventory (SPAI) Portuguese version in a heterogeneous sample of Brazilian university students. (15962137)
2005
41
The interpretation of negative social events in social phobia: changes during treatment and relationship to outcome. (15680932)
2005
42
Psychometric evaluation of the Social Anxiety Scale for Adolescents and the Social Phobia and Anxiety Inventory for Children: construct validity and normative data. (15275945)
2004
43
The etiology of social phobia: empirical evidence and an initial model. (15501555)
2004
44
Information-processing bias in social phobia. (15501557)
2004
45
Pharmacotherapy for social phobia. (15495010)
2004
46
Differential Effect of Mirror Manipulation on Self-Perception in Social Phobia Subtypes. (16770439)
2003
47
The relationship of olfactory delusional disorder to social phobia. (11838032)
2002
48
Cognitive-behavioral treatment for social phobia in Parkinson's disease: A single-case study. (16770438)
2001
49
Social phobia, avoidant personality disorder and atypical depression: co-occurrence and clinical implications. (9153683)
1997
50
Moclobemide in the treatment of social phobia. (8923114)
1996

Genetic Variations for Social Phobia

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Expression for genes affiliated with Social Phobia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Social Phobia

Search GEO for disease gene expression data for Social Phobia.

Pathways for genes affiliated with Social Phobia

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 29KEGG
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Compounds for genes affiliated with Social Phobia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Social Phobia according to GeneCards/GeneDecks:

(show top 50)    (show all 258)
idCompoundScoreTop Affiliating Genes
1amperozide449.8HTR3A, HTR1A, DRD2
2idazoxan449.7HTR1A, DRD2, MAOA
38-hydroxy-2-(di-n-propylamino)tetralin449.7HTR3A, HTR1A, SLC6A4
4methysergide44 28 1111.7HTR3A, CCK, HTR1A, MAOA
5benzodiazepine449.7HTR3A, MAOA, PTK7, CCK
6mianserin28 44 1111.7HTR1A, SLC6A4, MAOA, HTR3A
7sertraline44 28 49 11 2413.7HTR1A, SLC6A4, MAOA, HTR3A
8fluvoxamine44 49 1111.6SLC6A4, HTR1A, MAOA, HTR3A
9carbon-11449.6SLC6A4, MAOA, HTR1A
10maoa449.5HTR1A, MAOA, SLC6A4, DRD2
11m-chlorophenylpiperazine449.5SLC6A4, HTR3A, PRL, HTR1A
12mdma449.5SLC6A4, PRL, MAOA, HTR1A
13mcpp449.5SLC6A4, HTR1A, HTR3A, PRL
14nmda44 2810.5TACR1, MAOA, HTR1A
15pindolol44 28 1111.5PRL, SLC6A4, HTR3A, HTR1A
16ketanserin28 4410.5HTR1A, HTR3A, DRD2, SLC6A4
17p-chloroamphetamine449.5SLC6A4, HTR1A, MAOA
18buspirone44 28 1111.5HTR3A, HTR1A, DRD2, PRL
19ritanserin28 4410.5DRD2, HTR3A, HTR1A, PRL
20metoclopramide44 1110.4CCK, HTR3A, PRL, DRD2
21mhpg449.4PRL, MAOA, SLC6A4, NPY
22nemonapride49 44 2811.4PRL, DRD2, HTR1A
23ondansetron44 49 11 2412.4TACR1, HTR3A, HTR1A, CCK
24trimipramine49 44 1111.3PRL, SLC6A4, HTR1A, DRD2
25aripiprazole28 49 44 11 2413.3HTR3A, HTR1A, DRD2, PRL
26ziprasidone49 28 44 1112.3DRD2, HTR1A, HTR3A, PRL
27yohimbine44 28 2 1112.3HTR3A, NPY, HTR1A, DRD2
285-hydroxytryptophan449.2PRL, HTR3A, SLC6A4, HTR1A, PTK7
29amphetamine44 1110.2SLC6A4, MAOA, DRD2, NPY, CCK
30imipramine44 49 28 11 2413.2HTR3A, SLC6A4, TACR1, MAOA, HTR1A
31risperidone28 44 49 59 11 2414.1DRD2, SLC6A4, HTR1A, HTR3A, PRL
32fenfluramine28 44 1110.8CCK, SLC6A4, PRL, NPY, HTR3A, HTR1A
33clomipramine44 49 1110.8HTR3A, HTR1A, MAOA, TACR1, SLC6A4, PRL
34paroxetine44 49 28 1111.8MAOA, SLC6A4, TACR1, PRL, HTR3A, HTR1A
35octreotide44 59 28 1111.8NPY, CCK, TACR1, PRL, DRD2
36gaba448.7SLC6A4, DRD2, NPY, MAOA, PTK7, CCK
37epinephrine44 11 2410.6DRD2, NPY, PRL, MAOA, SLC6A4, PTK7
38clozapine44 28 49 1111.6HTR1A, PRL, TACR1, SLC6A4, DRD2, HTR3A
39cocaine44 119.6SLC6A4, PRL, DRD2, CCK, NPY
40citalopram49 44 11 2411.5MAOA, TACR1, SLC6A4, PTK7, PRL, HTR3A
41opiate448.5DRD2, PRL, CCK, TACR1, SLC6A4, NPY
42fluoxetine49 44 28 1111.4MAOA, HTR1A, HTR3A, DRD2, PRL, TACR1
436-hydroxydopamine448.4MAOA, SOD1, CAT, DRD2, NPY
44haloperidol44 28 2 49 1112.2DRD2, NPY, HTR3A, HTR1A, SLC6A4, TACR1
45levodopa44 119.1CAT, DRD2, MAOA, PRL, HTR1A, SOD1
46sodium nitroprusside448.0TACR1, NPY, SOD1, CAT, CCK
47acetylcholine44 49 28 11 2412.0HTR3A, HTR1A, DRD2, TACR1, CCK, NPY
485-hydroxytryptamine447.7SLC6A4, CCK, HTR1A, NPY, DRD2, PRL
49norepinephrine44 11 249.4PTK7, HTR1A, HTR3A, NPY, DRD2, PRL
50dopamine44 28 11 2410.4HTR1A, HTR3A, DRD2, PRL, MAOA, NPY

GO Terms for genes affiliated with Social Phobia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.5DRD2, HTR3A, CCK
2integral to plasma membraneGO:0058878.1PTK7, SLC6A4, TACR1, DRD2, HTR3A, HTR1A

Biological processes related to Social Phobia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.1HTR1A, HTR3A
2vasoconstrictionGO:0423109.9SLC6A4, HTR1A
3sperm ejaculationGO:0427139.8SLC6A4, TACR1
4response to cocaineGO:0422209.7DRD2, HTR3A
5positive regulation of renal sodium excretionGO:0358159.7TACR1, DRD2
6associative learningGO:0083069.6TACR1, DRD2
7response to morphineGO:0432789.6TACR1, DRD2
8behaviorGO:0076109.6TACR1, MAOA, NPY
9response to estradiol stimulusGO:0323559.4PRL, TACR1, SLC6A4
10eating behaviorGO:0427559.4TACR1, CCK
11response to hypoxiaGO:0016669.1CAT, DRD2, SLC6A4
12response to ethanolGO:0454718.9TACR1, PRL, SOD1
13response to drugGO:0424938.7SOD1, DRD2, PRL, SLC6A4

Molecular functions related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.8NPY, CCK

Products for genes affiliated with Social Phobia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Social Phobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet