MCID: SCL003
MIFTS: 60

Social Phobia malady

Mental diseases category
Download this MalaCard

Summaries for Social Phobia

About this section
Sources:
8Disease Ontology, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.

MalaCards: Social Phobia, also known as phobic anxiety disorder, is related to personality disorder and anxiety disorder. An important gene associated with Social Phobia is MAOA (monoamine oxidase A), and among its related pathways are Monoamine Transport and Monoamine GPCRs. The drugs gabapentin and gabapentin enacarbil and the compounds methysergide and benzodiazepine have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and testes, and related mouse phenotypes are integument and skeleton.

Aliases & Classifications for Social Phobia

About this section
Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 27ICD9CM, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

social phobia 8
phobic anxiety disorder 62
phobia, social 62
phobia social 45


External Ids:

Disease Ontology8 DOID:11257
ICD9CM27 300.23
NCIt40 C34927
SNOMED-CT58 25501002, 192395002
MeSH35 D010698
ICD1025 F40.1

Related Diseases for Social Phobia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Social Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder31.4MAOA, DRD2, SLC6A4
2anxiety disorder31.4MAOA, SLC6A4, HTR3A
3agoraphobia31.3PTK7, MAOA, HTR1A
4panic disorder31.2PTK7, CCK, HTR3A, HTR1A, SLC6A4
5generalized anxiety disorder31.2SLC6A4, HTR1A
6obsessive-compulsive disorder30.9MAOA, SLC6A4, DRD2, HTR3A, HTR1A
7drug dependence30.5DRD2, MAOA, SLC6A4
8parkinson's disease30.5HTR1A, MAOA, DRD2
9eating disorder30.4SLC6A4
10premature ejaculation30.3HTR1A, SLC6A4
11bipolar disorder30.3HTR1A, SLC6A4
12borderline personality disorder30.3MAOA, SLC6A4
13mood disorder30.3SLC6A4, NPY, TACR1, DRD2, HTR3A, HTR1A
14alcohol dependence30.2MAOA, SLC6A4, DRD2, NPY
15schizophrenia30.1SLC6A4, NPY, TACR1, DRD2, MAOA, HTR1A
16avoidant personality disorder10.9
17mutism10.5
18specific phobia10.4
19body dysmorphic disorder10.4
20separation anxiety disorder10.4
21blindness10.4
22acne10.3
23strabismus10.3
24elective mutism10.3
25insomnia10.3
26dependent personality disorder10.1
27animal phobia10.1
28cerebritis10.1
29delusional disorder10.1
30impulse control disorder10.1
31melancholia10.1MAOA
32biliary dyskinesia10.1CCK
33endogenous depression10.1MAOA
34pathological gambling10.1DRD2
35pervasive developmental disorder10.1SLC6A4
36hypermethioninemia10.1SOD1
37seasonal affective disorder10.1SLC6A4, HTR1A
38motion sickness10.1HTR1A, HTR3A
39bulimia nervosa10.1SLC6A4, CCK
40gastroparesis10.1HTR3A, CCK
41dyspepsia10.1HTR3A, CCK
42neuroleptic malignant syndrome10.1HTR1A, DRD2
43amnestic disorder10.1HTR1A, HTR3A
44restless legs syndrome10.1HTR3A, DRD2
45substance abuse10.1DRD2, SLC6A4
46serotonin syndrome10.1HTR1A, MAOA, HTR3A
47substance dependence10.1DRD2, SLC6A4
48carcinoid syndrome10.1MAOA, HTR3A, CCK
49neuroepithelioma10.1NPY, CCK
50diabetic cataract10.1CAT

Graphical network of the top 20 diseases related to Social Phobia:



Diseases related to social phobia

Symptoms for Social Phobia

About this section

Drugs & Therapeutics for Social Phobia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Social Phobia

Search NIH Clinical Center for Social Phobia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Social Phobia

About this section

Anatomical Context for Social Phobia

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Social Phobia:

33
Brain, Amygdala, Testes, Cortex, Pituitary, Heart, Hypothalamus, Cingulate cortex, Prefrontal cortex, Eye

Animal Models for Social Phobia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Social Phobia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.3SLC6A4, TACR1, DRD2, HTR3A, PRL
2MP:00053907.8TACR1, DRD2, SOD1, PTK7, NPY
3MP:00053797.8SLC6A4, DRD2, CCK, PRL, HTR3A, SOD1
4MP:00053857.5PTK7, TACR1, DRD2, SLC6A4, MAOA, HTR1A
5MP:00107687.0CAT, SLC6A4, DRD2, HTR1A, HTR3A, SOD1
6MP:00053866.2SLC6A4, PTK7, SOD1, PRL, HTR1A, MAOA
7MP:00036316.0TACR1, SLC6A4, NPY, PTK7, DRD2, MAOA
8MP:00053765.7HTR1A, CCK, PRL, HTR3A, SLC6A4, NPY

Publications for Social Phobia

About this section
Sources:
52PubMed
See all sources

Articles related to Social Phobia:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
The primary care diagnosis and management of social phobia and its relevance in the UK Armed Forces. (23691857)
2013
2
An investigator-blinded, randomized study to compare the efficacy of combined CBT for alcohol use disorders and social anxiety disorder versus CBT focused on alcohol alone in adults with comorbid disorders: the Combined Alcohol Social Phobia (CASP) trial protocol. (23895258)
2013
3
The SPAI-18, a brief version of the Social Phobia and Anxiety Inventory: Reliability and validity in clinically referred and non-referred samples. (23790687)
2013
4
Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder. (22592057)
2012
5
Childhood history of behavioral inhibition and comorbidity status in 256 adults with social phobia. (20797795)
2011
6
Social phobia and other psychiatric problems in children with strabismus. (21784213)
2011
7
Social fear and social phobia types among community youth: differential clinical features and vulnerability factors. (20684833)
2011
8
A randomized pilot study of mindfulness-based cognitive therapy and group cognitive-behavioral therapy for young adults with social phobia. (20210911)
2010
9
Learning to change a way of being: an interpretative phenomenological perspective on cognitive therapy for social phobia. (20413253)
2010
10
Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia. (20227458)
2010
11
Pre-treatment patient variables as predictors of drop-out and treatment outcome in cognitive behavioural therapy for social phobia: A systematic review. (20055730)
2010
12
Social norm processing in adult social phobia: atypically increased ventromedial frontal cortex responsiveness to unintentional (embarrassing) transgressions. (20889651)
2010
13
Health anxiety and fear of fear in panic disorder and agoraphobia vs. social phobia: a prospective longitudinal study. (20143435)
2010
14
Social phobia in late-life: is it worth a diagnosis? (20597874)
2010
15
Randomized controlled trial of Internet cognitive behavioural treatment for social phobia with and without motivational enhancement strategies. (20932208)
2010
16
Further study of the psychometric qualities of a brief screening tool for social phobia (MINI-SPIN) applied to clinical and nonclinical samples. (20883433)
2010
17
Cognitive behavioral group therapy for social phobia with or without attention training: a controlled trial. (19059753)
2009
18
Dreams In Jungian Psychology: The use of Dreams as an Instrument For Research, Diagnosis and Treatment of Social Phobia. (22135511)
2009
19
Changes in post-event processing and metacognitions during cognitive behavioral group therapy for social phobia. (19250799)
2009
20
A demonstration of the efficacy of two of the components of cognitive therapy for social phobia. (19081225)
2009
21
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
22
Beyond amygdala: Default Mode Network activity differs between patients with social phobia and healthy controls. (19559343)
2009
23
Assessing post-event processing after social situations: a measure based on the cognitive model for social phobia. (18350392)
2008
24
Frequency of social phobia and psychometric properties of the Liebowitz social anxiety scale in Parkinson's disease. (18661550)
2008
25
A new proposal for the subtypes of social phobia in a sample of Spanish adolescents. (17367987)
2008
26
Screening for social phobia in medical in- and outpatients with the German version of the Social Phobia Inventory (SPIN). (17923381)
2008
27
Shyness 2: treating social phobia online: replication and extension. (18612863)
2008
28
Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia. (17974937)
2007
29
Group cohesion in cognitive-behavioral group therapy for social phobia. (16928359)
2007
30
Treatment of social phobia through pure self-help and therapist-augmented self-help. (17766766)
2007
31
The social phobia and anxiety inventory: problem of underlying medical conditions. (18232422)
2007
32
Specificity of autobiographical memory in social phobia and major depression. (17472199)
2007
33
Temperament and character dimensions in patients with social phobia: patterns of change following treatments? (17328961)
2007
34
Therapeutic factors of cognitive behavioral group treatment for social phobia. (16614524)
2006
35
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
36
Intensive cognitive behavioural group treatment for social phobia: a pilot study. (15844687)
2005
37
Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. (15860337)
2005
38
Comparing the prevalence rates of social phobia in a community according to ICD-10 and DSM-III-R. (16224610)
2005
39
Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia. (16129496)
2005
40
Emerging treatments for child and adolescent social phobia: a review. (16190791)
2005
41
EEG mapping in patients with social phobia. (15465293)
2004
42
Social phobia and avoidant personality disorder: one spectrum disorder? (15204221)
2004
43
Social Phobia in an Italian region: do Italian studies show lower frequencies than community surveys conducted in other European countries? (15488146)
2004
44
Genome-wide linkage scan for loci predisposing to social phobia: evidence for a chromosome 16 risk locus. (14702251)
2004
45
Childhood stress and symptoms of drug dependence in adolescence and early adulthood: social phobia as a mediator. (9990437)
1999
46
The observer perspective: biased imagery in social phobia, agoraphobia, and blood/injury phobia. (10402690)
1999
47
Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. (9704868)
1998
48
Moclobemide in the treatment of social phobia. (8923114)
1996
49
Is elective mutism a social phobia? (8407760)
1993
50
Avoidant personality disorder and the generalized subtype of social phobia. (1583226)
1992

Variations for Social Phobia

About this section

Expression for genes affiliated with Social Phobia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Social Phobia

Search GEO for disease gene expression data for Social Phobia.

Pathways for genes affiliated with Social Phobia

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 5Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Social Phobia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity38
9.8SLC6A4, MAOA
2
Show member pathways
9.7DRD2, HTR1A
39.4MAOA, SOD1
49.2SLC6A4, MAOA, HTR1A, HTR3A
5
Show member pathways
Vitamin B12 Metabolism38
9.0SOD1, CAT
6
Show member pathways
9.0SOD1, CAT
79.0CAT, SOD1
8
Show member pathways
9.0CAT, SOD1
98.9NPY, HTR1A, SOD1
10
Show member pathways
8.8PRL, MAOA, DRD2, NPY
11
Show member pathways
8.8SLC6A4, DRD2, MAOA, HTR1A, HTR3A
128.8SOD1, MAOA, CAT
138.7HTR3A, HTR1A, MAOA, TACR1, SLC6A4
14
Show member pathways
7.9PRL, CCK, HTR1A, DRD2, TACR1, NPY
15
Show member pathways
7.9PRL, CCK, HTR1A, DRD2, TACR1, NPY

Compounds for genes affiliated with Social Phobia

About this section
Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB, 61Tocris Bioscience
See all sources

Compounds related to Social Phobia according to GeneCards/GeneDecks:

(show top 50)    (show all 296)
idCompoundScoreTop Affiliating Genes
1methysergide45 29 1111.6CCK, HTR3A, HTR1A, MAOA
2benzodiazepine459.6PTK7, MAOA, HTR3A, CCK
3amperozide459.5DRD2, HTR1A, HTR3A
4mianserin45 29 1111.5HTR1A, HTR3A, SLC6A4, MAOA
5Serotonin249.5MAOA, SLC6A4, HTR1A, HTR3A
6sertraline45 29 51 24 1113.5HTR3A, SLC6A4, MAOA, HTR1A
7fluvoxamine45 51 1111.5HTR1A, MAOA, SLC6A4, HTR3A
88-hydroxy-2-(di-n-propylamino)tetralin459.5HTR3A, HTR1A, SLC6A4
9maoa459.4DRD2, MAOA, HTR1A, SLC6A4
10mdma459.3HTR1A, SLC6A4, MAOA, PRL
11m-chlorophenylpiperazine459.3HTR3A, HTR1A, SLC6A4, PRL
12mcpp459.3HTR1A, HTR3A, PRL, SLC6A4
13ketanserin45 2910.3SLC6A4, DRD2, HTR1A, HTR3A
14pindolol45 29 1111.3HTR3A, HTR1A, SLC6A4, PRL
15buspirone45 29 1111.3PRL, HTR3A, HTR1A, DRD2
16ritanserin45 2910.3HTR1A, DRD2, HTR3A, PRL
17mhpg459.2PRL, MAOA, NPY, SLC6A4
18metoclopramide45 51 1111.2HTR3A, CCK, PRL, DRD2
19trimipramine45 51 1111.2SLC6A4, DRD2, PRL, HTR1A
20idazoxan459.2MAOA, DRD2, HTR1A
21amphetamine45 51 1111.1CCK, SLC6A4, MAOA, DRD2, NPY
22ondansetron51 45 24 1112.1HTR3A, HTR1A, TACR1, SLC6A4, CCK
23aripiprazole29 45 51 24 1113.0PRL, DRD2, HTR1A, HTR3A
245-hydroxytryptophan459.0SLC6A4, HTR1A, HTR3A, PRL, PTK7
25imipramine45 29 51 24 1113.0HTR3A, HTR1A, MAOA, TACR1, SLC6A4
26yohimbine45 3 29 1112.0HTR3A, HTR1A, DRD2, NPY
27ziprasidone29 51 45 1112.0HTR3A, PRL, HTR1A, DRD2
28quetiapine45 51 29 24 1112.9HTR1A, SLC6A4, HTR3A, PRL, DRD2
29risperidone45 51 29 61 24 1113.9PRL, HTR3A, HTR1A, DRD2, SLC6A4
30olanzapine45 51 29 24 1112.9PRL, HTR3A, SLC6A4, DRD2, HTR1A
31octreotide45 61 29 1111.7DRD2, PRL, NPY, TACR1, CCK
32fenfluramine45 29 1110.6SLC6A4, NPY, HTR1A, HTR3A, CCK, PRL
33clomipramine45 51 1110.6PRL, HTR3A, HTR1A, MAOA, TACR1, SLC6A4
34paroxetine45 51 29 1111.6TACR1, MAOA, HTR1A, PRL, SLC6A4, HTR3A
35gaba458.5CCK, SLC6A4, NPY, DRD2, MAOA, HTR3A
36epinephrine45 24 1110.4PTK7, PRL, DRD2, MAOA, SLC6A4, NPY
37clozapine45 29 51 1111.4TACR1, SLC6A4, DRD2, HTR1A, HTR3A, PRL
38acetylcholine45 51 29 24 1112.3HTR3A, DRD2, HTR1A, TACR1, NPY, CCK
39opiate458.3TACR1, NPY, SLC6A4, DRD2, CCK, PRL
40cocaine45 119.3NPY, PRL, CCK, DRD2, SLC6A4
41nmda45 299.3SLC6A4, MAOA, HTR1A, DRD2, TACR1, NPY
426-hydroxydopamine458.3NPY, MAOA, CAT, DRD2, SOD1
43citalopram45 51 24 1111.3HTR3A, SLC6A4, TACR1, MAOA, HTR1A, PRL
44fluoxetine45 51 29 1111.2MAOA, HTR1A, HTR3A, PRL, DRD2, SLC6A4
45haloperidol45 51 29 3 1112.0SLC6A4, NPY, TACR1, DRD2, HTR1A, PRL
46sodium nitroprusside458.0SOD1, NPY, CAT, TACR1, CCK
47levodopa45 118.9HTR1A, PRL, MAOA, DRD2, SOD1, CAT
485-hydroxytryptamine457.4HTR3A, HTR1A, MAOA, DRD2, TACR1, NPY
49dopamine45 29 24 1110.1PTK7, SLC6A4, NPY, PRL, CCK, HTR3A
50norepinephrine45 24 119.1CCK, HTR3A, HTR1A, MAOA, DRD2, TACR1

GO Terms for genes affiliated with Social Phobia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.4CCK, HTR3A, DRD2
2dendriteGO:0304259.3TACR1, DRD2, CCK
3integral component of plasma membraneGO:0058878.2DRD2, PTK7, HTR3A, HTR1A, SLC6A4, TACR1
4plasma membraneGO:0058866.8SLC6A4, SOD1, HTR3A, HTR1A, CAT, DRD2

Biological processes related to Social Phobia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00721010.1HTR3A, HTR1A
2vasoconstrictionGO:04231010.0HTR1A, SLC6A4
3behavioral fear responseGO:00166210.0CCK, HTR1A
4response to cocaineGO:04222010.0HTR3A, DRD2
5eating behaviorGO:0427559.9CCK, TACR1
6sperm ejaculationGO:0427139.9SLC6A4, TACR1
7positive regulation of renal sodium excretionGO:0358159.8TACR1, DRD2
8associative learningGO:0083069.8TACR1, DRD2
9response to morphineGO:0432789.8DRD2, TACR1
10response to nicotineGO:0350949.7TACR1, DRD2
11long-term memoryGO:0076169.6DRD2, TACR1
12cellular response to growth factor stimulusGO:0713639.6CAT, HTR3A
13feeding behaviorGO:0076319.5DRD2, NPY
14response to axon injuryGO:0486789.4SOD1, DRD2
15response to hypoxiaGO:0016669.4SLC6A4, DRD2, CAT
16response to amphetamineGO:0019759.2DRD2, SOD1
17regulation of multicellular organism growthGO:0400149.2SOD1, PRL
18response to ethanolGO:0454719.2TACR1, HTR3A, SOD1
19response to heatGO:0094088.8TACR1, SOD1

Molecular functions related to Social Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.8HTR1A, HTR3A
2neuropeptide hormone activityGO:0051849.6NPY, CCK
3protein homodimerization activityGO:0428037.9SOD1, CAT, DRD2, SLC6A4
4protein bindingGO:0055156.9SOD1, PRL, CCK, HTR1A, DRD2, TACR1

Products for genes affiliated with Social Phobia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Social Phobia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet