MCID: SFT003
MIFTS: 45

Soft Tissue Sarcoma malady

Rare diseases, Cancer diseases categories

Summaries for Soft Tissue Sarcoma

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35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your soft tissues connect, support, or surround other tissues. examples include your muscles, tendons, fat, and blood vessels. soft tissue sarcoma is a cancer of these soft tissues. there are many kinds, based on the type of tissue they started in. they may cause a lump or swelling in the soft tissue. sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. no one knows exactly what causes these cancers. they are not common, but you have a higher risk if you have been exposed to certain chemicals, have had radiation therapy, or have certain genetic diseases. doctors diagnose soft tissue sarcomas with a biopsy. treatments include surgery to remove the tumor, radiation therapy, chemotherapy, or a combination. nih: national cancer institute

MalaCards: Soft Tissue Sarcoma is related to sarcoma and synovial sarcoma. An important gene associated with Soft Tissue Sarcoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The compounds sestamibi and gluten have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and breast, and related mouse phenotype homeostasis/metabolism.

Wikipedia:66 A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is... more...

Aliases & Classifications for Soft Tissue Sarcoma

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44NIH Rare Diseases, 35MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

soft tissue sarcoma 44 35


Related Diseases for Soft Tissue Sarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Soft Tissue Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.2ABCB1, AIMP1, MKI67, FPGS, MDM2, CTAG1B
2synovial sarcoma30.9MKI67, MDM2, CTAG1B
3melanoma30.7AIMP1, HLA-G, MKI67, PRAME, NME1, MDM2
4retinoblastoma30.6HLA-G, MKI67, NME1, MDM2
5ovarian cancer30.6ABCB1, HLA-G, NME1, MDM2
6breast cancer30.6ABCB1, HLA-G, MKI67, NME1, MDM2, CTAG1B
7malignant peripheral nerve sheath tumor30.6ABCB1, MDM2
8leukemia30.2ABCB1, HLA-G, PRAME, IL2RA, FPGS, NME1
9myeloid leukemia30.2NME1, FPGS, ABCB1
10myeloma30.2CTAG1B, HLA-G, ABCB1
11colorectal cancer30.1ABCB1, AIMP1, HLA-G, FPGS, NME1, MDM2
12rhabdomyosarcoma10.8
13endotheliitis10.7
14fibrous histiocytoma10.5
15histiocytoma10.5
16hypoxia10.5
17alveolar soft part sarcoma10.5
18embryonal rhabdomyosarcoma10.4
19epithelioid sarcoma10.4
20hemangiopericytoma10.4
21dermatofibrosarcoma protuberans10.4
22alveolar rhabdomyosarcoma10.4
23myxoid liposarcoma10.4
24li-fraumeni syndrome10.4
25dermatofibrosarcoma10.4
26anaplastic large cell lymphoma10.4
27leiomyosarcoma10.4
28liposarcoma10.4
29osteosarcoma10.4
30thyroiditis10.4
31desmoplastic small round cell tumor10.4
32neurofibromatosis10.3
33gastrointestinal stromal tumor10.3
34hypercalcemia10.3
35fasciitis10.3
36hodgkin's lymphoma10.3
37prostatitis10.3
38renal cell carcinoma10.3
39wilms tumor10.3
40malignant mesenchymal tumor10.3
41soft tissue sarcoma childhood10.3
42aneurysm10.3
43hematopoietic stem cell transplantation10.3
44graft versus host disease10.1
45bone fracture10.1
46burn scar10.1
47burns10.1
48heart malignant hemangiopericytoma10.1
49pigmented villonodular synovitis10.1
50diabetes insipidus10.1

Graphical network of the top 20 diseases related to Soft Tissue Sarcoma:



Diseases related to soft tissue sarcoma

Symptoms for Soft Tissue Sarcoma

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Drugs & Therapeutics for Soft Tissue Sarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Soft Tissue Sarcoma

Drug clinical trials:

Search ClinicalTrials for Soft Tissue Sarcoma

Search NIH Clinical Center for Soft Tissue Sarcoma

Search CenterWatch for Soft Tissue Sarcoma

Genetic Tests for Soft Tissue Sarcoma

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Anatomical Context for Soft Tissue Sarcoma

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34MalaCards
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MalaCards organs/tissues related to Soft Tissue Sarcoma:

34
Bone, Endothelial, Breast, Brain, Bone marrow, Testes, Lung, Thyroid, Skin, Prostate, Lymph node, Testis, Liver, Cervix, Myeloid, Monocytes, T cells, Pituitary

Animal Models for Soft Tissue Sarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Soft Tissue Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1FGFR4, NME1, FPGS, XRCC2, HLA-G, AIMP1

Publications for Soft Tissue Sarcoma

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53PubMed
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Articles related to Soft Tissue Sarcoma:

(show top 50)    (show all 821)
idTitleAuthorsYear
1
Adherence to consensus-based diagnosis and treatment guidelines in adult soft-tissue sarcoma patients: a French prospective population-based study. (24285018)
2014
2
Monitoring the adequacy of surgical margins after resection of bone and soft-tissue sarcoma. (23370669)
2013
3
Comment on 'Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients': neutrophil to lymphocyte ratio may be predictor of mortality in patients with soft-tissue sarcoma. (23736026)
2013
4
PET/MRI for Preoperative Planning in Patients with Soft Tissue Sarcoma: A Technical Report of Two Patients. (24368921)
2013
5
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
6
Impact of unplanned excision on prognosis of patients with extremity soft tissue sarcoma. (23737702)
2013
7
Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall. (23725998)
2013
8
Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: importance of tumor proximity to skin surface. (23242820)
2013
9
Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma. (23423841)
2013
10
Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma. (22398019)
2012
11
Weekly gemcitabine and docetaxel in refractory soft tissue sarcoma: a retrospective analysis. (22500160)
2012
12
Assessment of referrals into the soft tissue sarcoma service: evaluation of imaging early in the pathway process. (22792037)
2012
13
Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma. (22407355)
2012
14
Impact of postoperative radiation on survival for high-grade soft tissue sarcoma of the extremities after limb sparing radical resection. (21278563)
2012
15
Pulmonary metastasectomy for soft tissue sarcoma. (22365519)
2012
16
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
17
Incidence and Severity of Lymphoedema following Limb Salvage of Extremity Soft Tissue Sarcoma. (22190861)
2011
18
PML down-regulation in soft tissue sarcomas. (20578240)
2010
19
TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo. (20406839)
2010
20
Surgery alone is adequate treatment for early stage soft tissue sarcoma of the extremity. (20235085)
2010
21
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. (21124965)
2010
22
Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control. (20393803)
2010
23
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. (19107931)
2009
24
Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma. (18707824)
2009
25
Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management. (19671034)
2009
26
Evaluating surgery quality in soft tissue sarcoma. (19230543)
2009
27
Improved diagnosis and treatment of soft tissue sarcoma patients after implementation of national guidelines: a population-based study. (19525085)
2009
28
Staging of soft tissue sarcoma: what is new? (18685895)
2008
29
p53 status correlates with histopathological response in patients with soft tissue sarcomas treated using isolated limb perfusion with TNF-alpha and melphalan. (18065405)
2008
30
Novel treatment strategies for soft tissue sarcoma. (17141519)
2007
31
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. (16953229)
2007
32
Adjuvant treatment of high-risk adult soft tissue sarcomas: a survey by the Italian Sarcoma Group. (16724686)
2006
33
Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography. (16506050)
2006
34
Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study. (15968689)
2005
35
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. (15355900)
2004
36
Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcoma. (14760675)
2004
37
Soft tissue sarcomas. Case 2. Orbital alveolar soft part sarcoma in a child. (15143097)
2004
38
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. (12738717)
2003
39
Fas-mediated signaling enhances sensitivity of human soft tissue sarcoma cells to anticancer drugs by activation of p38 kinase. (12516968)
2002
40
Aberrant immunohistochemical expression in nonrhabdomyosarcoma soft tissue sarcomas of infancy: retrospective review of clinical material. (12370769)
2002
41
Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. (11307150)
2001
42
Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines. (10725783)
1999
43
p53 status in radiation-induced soft-tissue sarcomas. (9739384)
1998
44
Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening. (9862568)
1998
45
Immunohistochemistry of MyoD1 in adult pleomorphic soft tissue sarcomas. (7872424)
1995
46
Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. (8133539)
1994
47
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. (8306343)
1994
48
Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines. (1377601)
1992
49
Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. (1988704)
1991
50
Soft tissue sarcoma with additional anaplastic components. A clinicopathologic and immunohistochemical study of 27 cases. (2208010)
1990

Variations for Soft Tissue Sarcoma

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Expression for genes affiliated with Soft Tissue Sarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Soft Tissue Sarcoma

Search GEO for disease gene expression data for Soft Tissue Sarcoma.

Pathways for genes affiliated with Soft Tissue Sarcoma

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 62Tocris Bioscience, 31KEGG
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Compounds for genes affiliated with Soft Tissue Sarcoma

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1sestamibi4610.3MKI67, ABCB1
2gluten4610.2IL2RA, HLA-G
3vinorelbine46 52 1212.1MKI67, ABCB1
4chi 24610.1MDM2, NME1, MKI67
5p000014610.1MDM2, MKI67
6trimetrexate46 1211.1ABCB1, FPGS
7ranitidine46 30 25 1213.1ABCB1, IL2RA
8irinotecan46 52 1212.0MDM2, MKI67, ABCB1
9ponatinib52 1211.0FGFR4, ABCB1
10p0024610.0MKI67, NME1, MDM2
11p0034610.0MDM2, MKI67, HLA-G
12lamivudine46 52 1212.0NME1, IL2RA, ABCB1
13dutp4610.0MDM2, MKI67
14mifepristone46 30 62 1212.9ABCB1, MKI67, IL2RA
152-chlorodeoxyadenosine469.9IL2RA, MDM2
16sn 3846 6210.9FPGS, ABCB1
17camptothecin46 62 1211.9MDM2, XRCC2, ABCB1
18quinidine46 30 52 1212.8MKI67, ABCB1
19vincristine46 52 1211.8MDM2, IL2RA, MKI67, ABCB1
20cyclophosphamide46 52 1211.7ABCB1, MKI67, IL2RA, MDM2
21etoposide46 52 62 1212.7MDM2, NME1, IL2RA, ABCB1
22folate469.7MKI67, IL2RA, FPGS
23paclitaxel46 52 1211.7ABCB1, MKI67, IL2RA, MDM2
24doxorubicin46 52 1211.7MDM2, IL2RA, MKI67, ABCB1
25epinephrine46 25 1211.7IL2RA, MKI67, ABCB1
26thymidylate469.6ABCB1, MKI67, FPGS, MDM2
27testosterone46 62 25 1212.6ABCB1, MKI67, IL2RA, MDM2
28steroid469.5MKI67, IL2RA, NME1, MDM2
29progesterone46 30 62 25 1213.5ABCB1, HLA-G, MKI67, NME1, MDM2
30dexamethasone46 52 30 1212.4ABCB1, HLA-G, IL2RA, NME1, MDM2
315-aza-2deoxycytidine469.4HLA-G, MDM2, CTAG1B
32paraffin469.4MKI67, IL2RA, NME1, MDM2, FGFR4
33thymidine46 2510.3MKI67, IL2RA, FPGS, NME1, MDM2
34mitomycin c469.3ABCB1, MKI67, XRCC2, FPGS, MDM2
35Adenosine triphosphate25 1210.1ABCB1, FPGS, NME1, MDM2, FGFR4
36cisplatin46 52 62 1212.1ABCB1, MKI67, XRCC2, IL2RA, NME1, MDM2
37vegf469.1HLA-G, MKI67, IL2RA, NME1, MDM2, FGFR4
385fluorouracil469.1ABCB1, MKI67, IL2RA, FPGS, NME1, MDM2
39methotrexate52 46 1211.0MDM2, FPGS, IL2RA, MKI67, HLA-G, ABCB1
40arginine468.9FGFR4, MDM2, IL2RA, MKI67

GO Terms for genes affiliated with Soft Tissue Sarcoma

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17Gene Ontology
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Biological processes related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:0311009.8FPGS, MKI67
2negative regulation of T cell proliferationGO:0421309.6IL2RA, HLA-G

Molecular functions related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055248.4FGFR4, NME1, FPGS, XRCC2, MKI67, ABCB1

Products for genes affiliated with Soft Tissue Sarcoma

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Sources for Soft Tissue Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet