MCID: SFT003
MIFTS: 49

Soft Tissue Sarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Soft Tissue Sarcoma

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MedlinePlus:33 Your soft tissues connect, support, or surround other tissues. examples include your muscles, tendons, fat, and blood vessels. soft tissue sarcoma is a cancer of these soft tissues. there are many kinds, based on the type of tissue they started in. they may cause a lump or swelling in the soft tissue. sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. no one knows exactly what causes these cancers. they are not common, but you have a higher risk if you have been exposed to certain chemicals, have had radiation therapy, or have certain genetic diseases. doctors diagnose soft tissue sarcomas with a biopsy. treatments include surgery to remove the tumor, radiation therapy, chemotherapy, or a combination. nih: national cancer institute

MalaCards based summary: Soft Tissue Sarcoma, also known as sarcoma, soft tissue, is related to sarcoma and synovial sarcoma. An important gene associated with Soft Tissue Sarcoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs ifosfamide and mitoxantrone and the compounds sestamibi and gluten have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and breast, and related mouse phenotype homeostasis/metabolism.

Wikipedia:65 A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is... more...

Aliases & Classifications for Soft Tissue Sarcoma

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Soft Tissue Sarcoma, Aliases & Descriptions:

Name: Soft Tissue Sarcoma 42 33
 
Sarcoma, Soft Tissue 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Soft Tissue Sarcoma

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Diseases related to Soft Tissue Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.4ABCB1, AIMP1, MKI67, FPGS, MDM2, CTAG1B
2synovial sarcoma31.2MKI67, MDM2, CTAG1B
3malignant peripheral nerve sheath tumor31.1ABCB1, MDM2
4ovarian cancer30.8ABCB1, HLA-G, NME1, MDM2
5retinoblastoma30.7HLA-G, MKI67, NME1, MDM2
6breast cancer30.6ABCB1, HLA-G, MKI67, NME1, MDM2, CTAG1B
7myeloid leukemia30.3NME1, FPGS, ABCB1
8acute lymphoblastic leukemia30.3ABCB1, PRAME, FPGS
9glioblastoma30.1FGFR4, MDM2, HLA-G, ABCB1
10myeloma30.1CTAG1B, HLA-G, ABCB1
11melanoma29.9AIMP1, HLA-G, MKI67, PRAME, NME1, MDM2
12colorectal cancer29.8ABCB1, AIMP1, HLA-G, FPGS, NME1, MDM2
13leukemia29.2ABCB1, HLA-G, PRAME, IL2RA, FPGS, NME1
14rhabdomyosarcoma10.8
15endotheliitis10.7
16hypoxia10.6
17fibrous histiocytoma10.5
18histiocytoma10.5
19alveolar soft part sarcoma10.5
20dermatofibrosarcoma protuberans10.5
21embryonal rhabdomyosarcoma10.4
22epithelioid sarcoma10.4
23hemangiopericytoma10.4
24lung cancer10.4ABCB1
25keratoacanthoma10.4NME1, MKI67
26uterine sarcoma10.4MDM2, ABCB1
27benign meningioma10.4MKI67, MDM2
28leukoplakia10.4MKI67, NME1
29anaplastic large cell lymphoma10.4
30myxoid liposarcoma10.4
31alveolar rhabdomyosarcoma10.4
32li-fraumeni syndrome10.4
33leiomyosarcoma10.4
34liposarcoma10.4
35osteosarcoma10.4
36thyroiditis10.4
37breast fibroadenoma10.4NME1, MKI67
38smooth muscle tumor10.4NME1, MKI67
39gestational trophoblastic neoplasm10.4NME1, HLA-G
40gallbladder cancer10.3NME1, MKI67
41malignant fibroxanthoma10.3MDM2, MKI67
42peripheral t-cell lymphoma10.3NME1, IL2RA
43breast cancer, invasive ductal10.3MDM2, NME1, MKI67
44cervical intraepithelial neoplasia10.3NME1, MKI67
45hemangioma10.3
46hematopoietic stem cell transplantation10.3
47hodgkin's lymphoma10.3
48renal cell carcinoma10.3
49wilms tumor10.3
50gastrointestinal stromal tumor10.3

Graphical network of the top 20 diseases related to Soft Tissue Sarcoma:



Diseases related to soft tissue sarcoma

Symptoms for Soft Tissue Sarcoma

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Drugs & Therapeutics for Soft Tissue Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Soft Tissue Sarcoma

Search NIH Clinical Center for Soft Tissue Sarcoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Soft Tissue Sarcoma

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Anatomical Context for Soft Tissue Sarcoma

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MalaCards organs/tissues related to Soft Tissue Sarcoma:

32
Bone, Endothelial, Breast, Neutrophil, Brain, Lung, Bone marrow, Thyroid, Skin, Testes, Lymph node, Prostate, Liver, Testis, Cervix, Myeloid, Monocytes, T cells, Pituitary

Animal Models for Soft Tissue Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Soft Tissue Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1FGFR4, NME1, FPGS, XRCC2, HLA-G, AIMP1

Publications for Soft Tissue Sarcoma

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Articles related to Soft Tissue Sarcoma:

(show top 50)    (show all 841)
idTitleAuthorsYear
1
Personalizing the Approach to Retroperitoneal Soft Tissue Sarcoma: Histology-specific Patterns of Failure and Postrelapse Outcome after Primary Extended Resection. (25300609)
2014
2
Hypofractionated radiation therapy for the treatment of microscopic canine soft tissue sarcoma. (25393921)
2014
3
Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients. (25324451)
2014
4
Soft tissue sarcoma misdiagnosed as benign peripheral neurogenic tumor. (25355660)
2014
5
Adherence to consensus-based diagnosis and treatment guidelines in adult soft-tissue sarcoma patients: a French prospective population-based study. (24285018)
2014
6
Monitoring the adequacy of surgical margins after resection of bone and soft-tissue sarcoma. (23370669)
2013
7
Comment on 'Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients': neutrophil to lymphocyte ratio may be predictor of mortality in patients with soft-tissue sarcoma. (23736026)
2013
8
PET/MRI for Preoperative Planning in Patients with Soft Tissue Sarcoma: A Technical Report of Two Patients. (24368921)
2013
9
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
10
Impact of unplanned excision on prognosis of patients with extremity soft tissue sarcoma. (23737702)
2013
11
Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall. (23725998)
2013
12
Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: importance of tumor proximity to skin surface. (23242820)
2013
13
Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma. (23423841)
2013
14
Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma. (22398019)
2012
15
Weekly gemcitabine and docetaxel in refractory soft tissue sarcoma: a retrospective analysis. (22500160)
2012
16
Assessment of referrals into the soft tissue sarcoma service: evaluation of imaging early in the pathway process. (22792037)
2012
17
Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma. (22407355)
2012
18
Impact of postoperative radiation on survival for high-grade soft tissue sarcoma of the extremities after limb sparing radical resection. (21278563)
2012
19
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
20
Incidence and Severity of Lymphoedema following Limb Salvage of Extremity Soft Tissue Sarcoma. (22190861)
2011
21
PML down-regulation in soft tissue sarcomas. (20578240)
2010
22
TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo. (20406839)
2010
23
Surgery alone is adequate treatment for early stage soft tissue sarcoma of the extremity. (20235085)
2010
24
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. (21124965)
2010
25
Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control. (20393803)
2010
26
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. (19107931)
2009
27
Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma. (18707824)
2009
28
Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management. (19671034)
2009
29
Evaluating surgery quality in soft tissue sarcoma. (19230543)
2009
30
Improved diagnosis and treatment of soft tissue sarcoma patients after implementation of national guidelines: a population-based study. (19525085)
2009
31
Staging of soft tissue sarcoma: what is new? (18685895)
2008
32
p53 status correlates with histopathological response in patients with soft tissue sarcomas treated using isolated limb perfusion with TNF-alpha and melphalan. (18065405)
2008
33
Novel treatment strategies for soft tissue sarcoma. (17141519)
2007
34
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. (16953229)
2007
35
Adjuvant treatment of high-risk adult soft tissue sarcomas: a survey by the Italian Sarcoma Group. (16724686)
2006
36
Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography. (16506050)
2006
37
Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study. (15968689)
2005
38
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. (15355900)
2004
39
Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcoma. (14760675)
2004
40
Soft tissue sarcomas. Case 2. Orbital alveolar soft part sarcoma in a child. (15143097)
2004
41
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. (12738717)
2003
42
Fas-mediated signaling enhances sensitivity of human soft tissue sarcoma cells to anticancer drugs by activation of p38 kinase. (12516968)
2002
43
Aberrant immunohistochemical expression in nonrhabdomyosarcoma soft tissue sarcomas of infancy: retrospective review of clinical material. (12370769)
2002
44
Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines. (10725783)
1999
45
p53 status in radiation-induced soft-tissue sarcomas. (9739384)
1998
46
Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening. (9862568)
1998
47
Immunohistochemistry of MyoD1 in adult pleomorphic soft tissue sarcomas. (7872424)
1995
48
Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. (8133539)
1994
49
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. (8306343)
1994
50
Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. (1988704)
1991

Variations for Soft Tissue Sarcoma

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Expression for genes affiliated with Soft Tissue Sarcoma

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Expression patterns in normal tissues for genes affiliated with Soft Tissue Sarcoma

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Pathways for genes affiliated with Soft Tissue Sarcoma

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Compounds for genes affiliated with Soft Tissue Sarcoma

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Compounds related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1sestamibi4410.3MKI67, ABCB1
2gluten4410.2IL2RA, HLA-G
3vinorelbine44 50 1112.1MKI67, ABCB1
4chi 24410.1MDM2, NME1, MKI67
5p000014410.1MDM2, MKI67
6trimetrexate44 1111.1ABCB1, FPGS
7ranitidine44 28 24 1113.1ABCB1, IL2RA
8irinotecan44 50 1112.0MDM2, MKI67, ABCB1
9ponatinib50 1111.0FGFR4, ABCB1
10p0024410.0MKI67, NME1, MDM2
11p0034410.0MDM2, MKI67, HLA-G
12lamivudine44 50 1112.0NME1, IL2RA, ABCB1
13dutp4410.0MDM2, MKI67
14mifepristone44 28 61 1112.9ABCB1, MKI67, IL2RA
152-chlorodeoxyadenosine449.9IL2RA, MDM2
16sn 3844 6110.9FPGS, ABCB1
17camptothecin44 61 1111.9MDM2, XRCC2, ABCB1
18quinidine44 28 50 1112.8MKI67, ABCB1
19vincristine44 50 1111.8MDM2, IL2RA, MKI67, ABCB1
20cyclophosphamide44 50 1111.7ABCB1, MKI67, IL2RA, MDM2
21etoposide44 50 61 1112.7MDM2, NME1, IL2RA, ABCB1
22folate449.7MKI67, IL2RA, FPGS
23paclitaxel44 50 1111.7ABCB1, MKI67, IL2RA, MDM2
24doxorubicin44 50 1111.7MDM2, IL2RA, MKI67, ABCB1
25epinephrine44 24 1111.7IL2RA, MKI67, ABCB1
26thymidylate449.6ABCB1, MKI67, FPGS, MDM2
27testosterone44 61 24 1112.6ABCB1, MKI67, IL2RA, MDM2
28steroid449.5MKI67, IL2RA, NME1, MDM2
29progesterone44 28 61 24 1113.5ABCB1, HLA-G, MKI67, NME1, MDM2
30dexamethasone44 50 28 1112.4ABCB1, HLA-G, IL2RA, NME1, MDM2
315-aza-2deoxycytidine449.4HLA-G, MDM2, CTAG1B
32paraffin449.4MKI67, IL2RA, NME1, MDM2, FGFR4
33thymidine44 2410.3MKI67, IL2RA, FPGS, NME1, MDM2
34mitomycin c449.3ABCB1, MKI67, XRCC2, FPGS, MDM2
35Adenosine triphosphate24 1110.1ABCB1, FPGS, NME1, MDM2, FGFR4
36cisplatin44 50 61 1112.1ABCB1, MKI67, XRCC2, IL2RA, NME1, MDM2
37vegf449.1HLA-G, MKI67, IL2RA, NME1, MDM2, FGFR4
385fluorouracil449.1ABCB1, MKI67, IL2RA, FPGS, NME1, MDM2
39methotrexate50 44 1111.0MDM2, FPGS, IL2RA, MKI67, HLA-G, ABCB1
40arginine448.9FGFR4, MDM2, IL2RA, MKI67

GO Terms for genes affiliated with Soft Tissue Sarcoma

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Biological processes related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:0311009.8FPGS, MKI67
2negative regulation of T cell proliferationGO:0421309.6IL2RA, HLA-G

Molecular functions related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055248.4FGFR4, NME1, FPGS, XRCC2, MKI67, ABCB1

Products for genes affiliated with Soft Tissue Sarcoma

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Sources for Soft Tissue Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet