MCID: SFT003
MIFTS: 46

Soft Tissue Sarcoma malady

Cancer category

Summaries for Soft Tissue Sarcoma

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your soft tissues connect, support, or surround other tissues. examples include your muscles, tendons, fat, and blood vessels. soft tissue sarcoma is a cancer of these soft tissues. there are many kinds, based on the type of tissue they started in. they may cause a lump or swelling in the soft tissue. sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. no one knows exactly what causes these cancers. they are not common, but you have a higher risk if you have been exposed to certain chemicals, have had radiation therapy, or have certain genetic diseases. doctors diagnose soft tissue sarcomas with a biopsy. treatments include surgery to remove the tumor, radiation therapy, chemotherapy, or a combination. nih: national cancer institute

MalaCards: Soft Tissue Sarcoma is related to synovial sarcoma and uterine sarcoma. An important gene associated with Soft Tissue Sarcoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are Akt Signaling and Rho Family GTPases. The compounds 5fluorouracil and vegf have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are hematopoietic system and tumorigenesis.

Wikipedia:64 A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is... more...

Aliases & Classifications for Soft Tissue Sarcoma

Sources:
43NIH Rare Diseases, 34MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

soft tissue sarcoma 43 34


Related Diseases for Soft Tissue Sarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Soft Tissue Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1synovial sarcoma30.8CTAG1B, MDM2, MKI67, KIT
2uterine sarcoma30.5KIT, ABCB1, MDM2
3acute leukemia30.4MVP, CSF3, HLA-G, PRAME, ABCB1, KIT
4gastrointestinal stromal tumor30.4MKI67, KIT
5colorectal cancer30.2NME1, ABCB1, MKI67, MDM2, MVP
6clear cell sarcoma30.2LATS1
7acute lymphoblastic leukemia, childhood30.2ABCB1, MDM2, MVP
8pleomorphic liposarcoma30.2KIT, MDM2
9fibromatosis30.2KIT
10soft tissue sarcoma childhood10.6
11fibrous histiocytoma10.5
12hypoxia10.5
13dermatofibrosarcoma protuberans10.5
14alveolar soft part sarcoma10.4
15embryonal sarcoma10.4
16dermatofibrosarcoma10.4
17alveolar rhabdomyosarcoma10.4
18brain sarcoma10.4
19bladder sarcoma10.4
20myxoid liposarcoma10.4
21anaplastic large cell lymphoma10.4
22skin sarcoma10.4
23thyroid sarcoma10.4
24desmoplastic small round cell tumor10.4
25neurofibromatosis10.3
26hypercalcemia10.3
27li-fraumeni syndrome10.3
28wilms tumor10.3
29malignant mesenchymal tumor10.3
30hematopoietic stem cell transplantation10.3
31graft versus host disease10.1
32bone fracture10.1
33burn scar10.1
34pigmented villonodular synovitis10.1
35papillary carcinoma10.1
36prostate embryonal rhabdomyosarcoma10.1
37vaccinia10.1
38acute myeloid leukemia10.1
39xeroderma pigmentosum10.1
40yellow nail syndrome10.1
41neurofibrosarcoma10.1
42pulmonary sclerosing hemangioma10.1
43diabetes insipidus10.1
44villonodular synovitis10.1
45breast rhabdomyosarcoma10.1
46rhinosporidiosis10.1
47bone lymphoma10.1
48follicular dendritic cell sarcoma10.1
49beckwith-wiedemann syndrome10.1
50myositis ossificans10.1

Graphical network of the top 20 diseases related to Soft Tissue Sarcoma:



Diseases related to soft tissue sarcoma

Clinical Features for Soft Tissue Sarcoma

Drugs & Therapeutics for Soft Tissue Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Soft Tissue Sarcoma

Drug clinical trials:

Search ClinicalTrials for Soft Tissue Sarcoma

Search NIH Clinical Center for Soft Tissue Sarcoma

Search CenterWatch for Soft Tissue Sarcoma

Genetic Tests for Soft Tissue Sarcoma

Anatomical Context for Soft Tissue Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Soft Tissue Sarcoma:

33
Skin, Ovary, Liver, Brain, Lymph node, Lung, Bone marrow, Whole blood, Thyroid, Breast, Prostate, Testis, Cervix, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pituitary, Testis germ

Animal Models for Soft Tissue Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Soft Tissue Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.1PATZ1, TUSC2, CSF3, HLA-G, MDK, MDM2
2MP:000200610.9MDM2, ING2, IL12A, NME1, KIT, LATS1
3MP:000538710.9MDK, HLA-G, CSF3, TUSC2, MDM2, ING2

Publications for Soft Tissue Sarcoma

Sources:
51PubMed
See all sources

Articles related to Soft Tissue Sarcoma:

(show top 50)    (show all 898)
idTitleAuthorsYear
1
Complete pathologic response in soft tissue sarcoma lung metastases with pazopanib. (24346105)
2014
2
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
3
Clinical Features and Outcomes of Young Patients with Head and Neck Non-Rhabdomyosarcoma Soft Tissue Sarcomas. (24327514)
2013
4
Analyzing the "CareGap": assessing gaps in adherence to clinical guidelines in adult soft tissue sarcoma. (23542965)
2013
5
Pazopanib, a new therapy for metastatic soft tissue sarcoma. (23488774)
2013
6
Subcutaneous fluid port-associated soft tissue sarcoma in a cat. (23413270)
2013
7
Effective utilization of chest X-ray for follow-up of metastatic lung tumor due to soft tissue sarcoma. (22971713)
2013
8
Prognostic factors in adult soft tissue sarcoma treated with surgery combined with radiotherapy: a retrospective single-center study on 164 patients. (24416489)
2013
9
In regard to RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies: in regard to Wang et al (Int J Radiat Oncol Biol Phys 2011;81:e525-e528). (22579375)
2012
10
A clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma. (22788989)
2012
11
Genotoxic and cytotoxic activity of host defense peptides against human soft tissue sarcoma in an in vitro model. (21851146)
2012
12
CD99-positive soft tissue sarcoma with chromosomal translocation between 1 and 16 and inversion of chromosome 5. (22783420)
2012
13
Phase II studies in soft tissue sarcoma: time for reappraisal. (22285964)
2012
14
A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma. (22152120)
2011
15
Topoisomerase II-alpha protein expression and histological response following doxorubicin-based induction chemotherapy predict survival of locally advanced soft tissues sarcomas. (21450455)
2011
16
Cost-utility and expected value of perfect information related to trabectedin in the treatment of metastatic soft-tissue sarcoma: the publicly funded comments explored. (21555363)
2011
17
Feasibility of metronomic oral cyclophosphamide plus prednisolone in elderly patients with inoperable or metastatic soft tissue sarcoma. (21251814)
2011
18
Prognostic value of computed tomography for monitoring pulmonary metastases in soft tissue sarcoma patients after surgical management: a retrospective cohort study. (21537873)
2011
19
PML down-regulation in soft tissue sarcomas. (20578240)
2010
20
Randomized clinical trials in soft tissue sarcoma. (19914557)
2010
21
Role of surgical resection in adult urological soft tissue sarcoma: 25-year experience. (20389161)
2010
22
Management of adult soft-tissue sarcoma of the extremities and trunk. (20131999)
2010
23
Standardized approach to the treatment of adult soft tissue sarcoma of the extremities. (19230542)
2009
24
Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma. (19417021)
2009
25
Hyperthermia as an adjunctive treatment for soft-tissue sarcoma. (19192958)
2009
26
Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients. (19047283)
2009
27
Comparison of conventional radiotherapy and intensity-modulated radiotherapy for post-operative radiotherapy for primary extremity soft tissue sarcoma. (19604591)
2009
28
Midkine enhances soft-tissue sarcoma growth: a possible novel therapeutic target. (18698021)
2008
29
Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. (18981463)
2008
30
Molecular pathology and potential therapeutic targets in soft-tissue sarcoma. (18533803)
2008
31
SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma. (18580682)
2008
32
Aberrant expression of the Rb pathway proteins in soft tissue sarcomas. (17122635)
2006
33
High-dose ifosfamide with hematopoietic growth factor support in advanced bone and soft tissue sarcomas. (15627067)
2004
34
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. (12738717)
2003
35
Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma. (12949814)
2003
36
Expression of multidrug resistance genes MVP, MDR1, and MRP1 determined sequentially before, during, and after hyperthermic isolated limb perfusion of soft tissue sarcoma and melanoma patients. (12149303)
2002
37
Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression. (11745235)
2001
38
Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial. (11230464)
2001
39
Isolated limb perfusion for extremity soft-tissue sarcomas, in-transit metastases, and other unresectable tumors: credits, debits, and future perspectives. (11389822)
2001
40
Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent. (11555609)
2001
41
Hyperthermic isolated limb perfusion with tumor necrosis factor-alpha and melphalan in advanced soft-tissue sarcomas: histopathological considerations. (10761796)
2000
42
Inhibition of proliferation and induction of apoptosis in soft tissue sarcoma cells by interferon-alpha and retinoids. (10424735)
1999
43
Clear cell sarcoma of soft tissues. Clinico-pathological and ultrastructural analysis of a case in the head-neck region and a literature review]. (9793401)
1998
44
Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: a phase II study. (9552049)
1998
45
Progression of inflammatory myofibroblastic tumor (inflammatory pseudotumor) of soft tissue into sarcoma after several recurrences. (8892598)
1996
46
Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas. (8821948)
1996
47
Diagnosis and treatment of soft tissue sarcomas in adults. (7803538)
1994
48
Histopathologic diagnostic and histogenetic problems in malignant soft tissue tumors. Reassessment of malignant fibrous histiocytoma, epithelioid sarcoma, malignant rhabdoid tumor, and neuroectodermal tumor. (1466243)
1992
49
Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene. (2216456)
1990
50
Paraneoplastic syndromes with soft-tissue sarcoma: a report of two unusual cases. (6314049)
1983

Genetic Variations for Soft Tissue Sarcoma

Expression for genes affiliated with Soft Tissue Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Soft Tissue Sarcoma

Search GEO for disease gene expression data for Soft Tissue Sarcoma.

Pathways for genes affiliated with Soft Tissue Sarcoma

Sources:
52QIAGEN, 30KEGG
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Pathways related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9KIT, CSF3, MDK, MDM2, IL2RA, IL12A
2
Hide members
10.9MDK, MDM2, IL2RA, IL12A, KIT, CSF3
3
Hide members
10.8KIT, IL12A, IL2RA, MDK, CSF3
410.7KIT, IL2RA, MDM2, HLA-G
510.7CSF3, IL2RA, KIT

Compounds for genes affiliated with Soft Tissue Sarcoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
15fluorouracil4511.5KIT, MVP, CSF3, MDM2, MKI67, IL2RA
2vegf4511.4MVP, CSF3, HLA-G, MDM2, MKI67, IL2RA
3methotrexate45 50 1113.4CSF3, HLA-G, MDM2, MKI67, IL2RA, ABCB1
4vincristine45 50 1113.4MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
5doxorubicin45 50 1113.4MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
6cisplatin45 50 60 1114.4MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
7progesterone45 60 29 11 2415.4MVP, HLA-G, MDM2, MKI67, ABCB1, NME1
8cyclophosphamide45 50 1113.3MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
9etoposide45 50 60 1114.3MVP, CSF3, MDM2, IL2RA, ABCB1, NME1
10paraffin4511.3MVP, MDM2, MKI67, IL2RA, NME1, KIT
11thymidine45 2412.3CSF3, MDM2, MKI67, IL2RA, NME1, KIT
12irinotecan45 50 1113.2CSF3, MDM2, MKI67, ABCB1, KIT
13p0034511.2MVP, HLA-G, MDM2, MKI67, KIT
14mitomycin c4511.2ABCB1, MKI67, MDM2, CSF3, MVP
15p0024511.2MVP, MDM2, MKI67, NME1, KIT
16docetaxel45 50 60 1114.2KIT, ABCB1, MDM2, CSF3, MVP
17paclitaxel45 50 1113.2MVP, CSF3, MDM2, ABCB1
18epinephrine45 11 2413.2MVP, CSF3, MKI67, IL2RA, ABCB1
192-chlorodeoxyadenosine4511.2CSF3, MDM2, IL2RA, KIT
20mycophenolate mofetil45 50 1113.2CSF3, IL2RA, IL12A, ABCB1
21melphalan45 1112.1MVP, CSF3, MDM2, ABCB1
22daunorubicin45 50 1113.1MVP, CSF3, MDM2, ABCB1
23vinblastine45 50 1113.1MVP, CSF3, MDM2, ABCB1
24cytarabine45 50 1113.1KIT, ABCB1, CSF3, MVP
25thymidylate4511.1ABCB1, MKI67, MDM2, MVP
26prednisolone45 29 1113.1MVP, CSF3, IL2RA, ABCB1
27adriamycin4511.1MVP, CSF3, MDM2, ABCB1
28chi 24511.1MDM2, MKI67, NME1
29idarubicin45 50 1113.1ABCB1, CSF3, MVP
30rhodamine 12345 5012.0KIT, ABCB1, MVP
31vinorelbine45 1112.0CSF3, MKI67, ABCB1
32imatinib45 50 1113.0CSF3, MDM2, ABCB1, KIT
33lamivudine45 1112.0IL2RA, ABCB1, NME1
34gramicidin d45 1112.0MVP, ABCB1
35dexamethasone45 50 29 1113.9NME1, ABCB1, MDM2
36r 1234510.9MVP, ABCB1
37daunoxome4510.9CSF3, ABCB1
38mitoxantrone45 50 1112.9MVP, CSF3, ABCB1
39pirarubicin4510.9ABCB1, CSF3
40sestamibi4510.8ABCB1
41acnu4510.8ABCB1, CSF3
42carbimazole45 1111.8IL2RA, CSF3
43nilotinib50 1111.8ABCB1, KIT
44p-0074510.8MKI67, KIT
45carboplatin45 50 1112.7CSF3, MDM2, ABCB1
46gluten4510.7HLA-G, IL2RA
47gefitinib45 50 1112.7MDM2, ABCB1, KIT
48homoharringtonine45 1111.6ABCB1, CSF3
49estrogen4510.4MVP
50bleomycin45 1111.4IL2RA, CSF3, MVP

GO Terms for genes affiliated with Soft Tissue Sarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell differentiationGO:04558210.6IL12A, IL2RA

Products for genes affiliated with Soft Tissue Sarcoma

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Sources for Soft Tissue Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet