MCID: SFT003
MIFTS: 44

Soft Tissue Sarcoma malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Soft Tissue Sarcoma

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Soft Tissue Sarcoma, Aliases & Descriptions:

Name: Soft Tissue Sarcoma 41 32
 
Sarcoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Soft Tissue Sarcoma

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MedlinePlus:32 Your soft tissues connect, support, or surround other tissues. examples include your muscles, tendons, fat, and blood vessels. soft tissue sarcoma is a cancer of these soft tissues. there are many kinds, based on the type of tissue they started in. they may cause a lump or swelling in the soft tissue. sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. no one knows exactly what causes these cancers. they are not common, but you have a higher risk if you have been exposed to certain chemicals, have had radiation therapy, or have certain genetic diseases. doctors diagnose soft tissue sarcomas with a biopsy. treatments include surgery to remove the tumor, radiation therapy, chemotherapy, or a combination. nih: national cancer institute

MalaCards based summary: Soft Tissue Sarcoma, also known as sarcoma, is related to sarcoma and breast cancer. An important gene associated with Soft Tissue Sarcoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs ifosfamide and mitoxantrone and the compounds sestamibi and gluten have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and breast, and related mouse phenotype homeostasis/metabolism.

Wikipedia:63 A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is... more...

Related Diseases for Soft Tissue Sarcoma

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Diseases related to Soft Tissue Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.4ABCB1, AIMP1, MKI67, FPGS, MDM2, CTAG1B
2breast cancer31.2MDM2, NME1, MKI67
3malignant peripheral nerve sheath tumor31.1ABCB1, MDM2
4sarcoma, synovial31.1MKI67, MDM2, CTAG1B
5retinoblastoma30.9HLA-G, MKI67, NME1, MDM2
6myeloid leukemia30.3NME1, FPGS, ABCB1
7glioblastoma30.1FGFR4, MDM2, HLA-G, ABCB1
8myeloma30.1CTAG1B, HLA-G, ABCB1
9adenocarcinoma30.1ABCB1, HLA-G, MKI67, NME1, MDM2, CTAG1B
10melanoma29.9AIMP1, HLA-G, MKI67, PRAME, NME1, MDM2
11colorectal cancer29.8ABCB1, FPGS, NME1, MDM2, FGFR4
12leukemia29.2ABCB1, HLA-G, PRAME, IL2RA, FPGS, NME1
13rhabdomyosarcoma10.8
14endotheliitis10.7
15hypoxia10.6
16alveolar soft-part sarcoma10.5
17dermatofibrosarcoma protuberans10.5
18fibrous histiocytoma10.5
19histiocytoma10.5
20li-fraumeni syndrome10.5
21embryonal rhabdomyosarcoma10.5
22epithelioid sarcoma10.5
23hemangiopericytoma10.5
24liposarcoma10.5
25lung cancer10.4ABCB1
26keratoacanthoma10.4NME1, MKI67
27uterine sarcoma10.4MDM2, ABCB1
28benign meningioma10.4MKI67, MDM2
29hodgkin lymphoma10.4
30anaplastic large cell lymphoma10.4
31leiomyosarcoma10.4
32thyroiditis10.4
33soft tissue sarcoma childhood10.4
34leukoplakia10.4MKI67, NME1
35breast fibroadenoma10.4NME1, MKI67
36smooth muscle tumor10.4NME1, MKI67
37gestational trophoblastic neoplasm10.4NME1, HLA-G
38gallbladder cancer10.3NME1, MKI67
39malignant fibroxanthoma10.3MDM2, MKI67
40peripheral t-cell lymphoma10.3NME1, IL2RA
41gastrointestinal stromal tumor10.3
42ewing sarcoma10.3
43renal cell carcinoma10.3
44wilms tumor10.3
45hemangioma10.3
46hematopoietic stem cell transplantation10.3
47neutropenia10.3
48hypercalcemia10.3
49fasciitis10.3
50prostatitis10.3

Graphical network of the top 20 diseases related to Soft Tissue Sarcoma:



Diseases related to soft tissue sarcoma

Symptoms for Soft Tissue Sarcoma

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Drugs & Therapeutics for Soft Tissue Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Soft Tissue Sarcoma

Search NIH Clinical Center for Soft Tissue Sarcoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Soft Tissue Sarcoma

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Anatomical Context for Soft Tissue Sarcoma

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MalaCards organs/tissues related to Soft Tissue Sarcoma:

31
Bone, Endothelial, Breast, Neutrophil, Lung, Brain, Bone marrow, Thyroid, Skin, Testes, Lymph node, Prostate, Monocytes, Liver, Testis, Cervix, Myeloid, T cells, Pituitary

Animal Models for Soft Tissue Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Soft Tissue Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1FGFR4, NME1, FPGS, XRCC2, HLA-G, AIMP1

Publications for Soft Tissue Sarcoma

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Articles related to Soft Tissue Sarcoma:

(show top 50)    (show all 862)
idTitleAuthorsYear
1
A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments. (25885530)
2015
2
Personalizing the Approach to Retroperitoneal Soft Tissue Sarcoma: Histology-specific Patterns of Failure and Postrelapse Outcome after Primary Extended Resection. (25300609)
2014
3
Hypofractionated radiation therapy for the treatment of microscopic canine soft tissue sarcoma. (25393921)
2014
4
Uric acid levels in blood are associated with clinical outcome in soft-tissue sarcoma patients. (25324451)
2014
5
Soft tissue sarcoma misdiagnosed as benign peripheral neurogenic tumor. (25355660)
2014
6
Adherence to consensus-based diagnosis and treatment guidelines in adult soft-tissue sarcoma patients: a French prospective population-based study. (24285018)
2014
7
Monitoring the adequacy of surgical margins after resection of bone and soft-tissue sarcoma. (23370669)
2013
8
Comment on 'Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients': neutrophil to lymphocyte ratio may be predictor of mortality in patients with soft-tissue sarcoma. (23736026)
2013
9
PET/MRI for Preoperative Planning in Patients with Soft Tissue Sarcoma: A Technical Report of Two Patients. (24368921)
2013
10
Lenograstim in preventing chemotherapy-induced febrile neutropenia in patients with soft tissue sarcoma. (23393367)
2013
11
Impact of unplanned excision on prognosis of patients with extremity soft tissue sarcoma. (23737702)
2013
12
Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall. (23725998)
2013
13
Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: importance of tumor proximity to skin surface. (23242820)
2013
14
Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma. (22398019)
2012
15
Weekly gemcitabine and docetaxel in refractory soft tissue sarcoma: a retrospective analysis. (22500160)
2012
16
Assessment of referrals into the soft tissue sarcoma service: evaluation of imaging early in the pathway process. (22792037)
2012
17
Long-term results of primary and secondary resections in patients with retroperitoneal soft tissue sarcoma. (22407355)
2012
18
Impact of postoperative radiation on survival for high-grade soft tissue sarcoma of the extremities after limb sparing radical resection. (21278563)
2012
19
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
20
Incidence and Severity of Lymphoedema following Limb Salvage of Extremity Soft Tissue Sarcoma. (22190861)
2011
21
PML down-regulation in soft tissue sarcomas. (20578240)
2010
22
TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo. (20406839)
2010
23
Surgery alone is adequate treatment for early stage soft tissue sarcoma of the extremity. (20235085)
2010
24
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. (21124965)
2010
25
Aggressive surgery in retroperitoneal soft tissue sarcoma carried out at high-volume centers is safe and is associated with improved local control. (20393803)
2010
26
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. (19107931)
2009
27
Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma. (18707824)
2009
28
Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management. (19671034)
2009
29
Evaluating surgery quality in soft tissue sarcoma. (19230543)
2009
30
Improved diagnosis and treatment of soft tissue sarcoma patients after implementation of national guidelines: a population-based study. (19525085)
2009
31
Staging of soft tissue sarcoma: what is new? (18685895)
2008
32
p53 status correlates with histopathological response in patients with soft tissue sarcomas treated using isolated limb perfusion with TNF-alpha and melphalan. (18065405)
2008
33
Novel treatment strategies for soft tissue sarcoma. (17141519)
2007
34
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. (16953229)
2007
35
Adjuvant treatment of high-risk adult soft tissue sarcomas: a survey by the Italian Sarcoma Group. (16724686)
2006
36
Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography. (16506050)
2006
37
Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study. (15968689)
2005
38
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas. (15355900)
2004
39
Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcoma. (14760675)
2004
40
Soft tissue sarcomas. Case 2. Orbital alveolar soft part sarcoma in a child. (15143097)
2004
41
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. (12738717)
2003
42
Fas-mediated signaling enhances sensitivity of human soft tissue sarcoma cells to anticancer drugs by activation of p38 kinase. (12516968)
2002
43
Aberrant immunohistochemical expression in nonrhabdomyosarcoma soft tissue sarcomas of infancy: retrospective review of clinical material. (12370769)
2002
44
Secretion of noncomplexed 'Big' (10-18 kD) forms of insulin-like growth factor-II by 12 soft tissue sarcoma cell lines. (10725783)
1999
45
p53 status in radiation-induced soft-tissue sarcomas. (9739384)
1998
46
Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening. (9862568)
1998
47
Immunohistochemistry of MyoD1 in adult pleomorphic soft tissue sarcomas. (7872424)
1995
48
Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. (8133539)
1994
49
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. (8306343)
1994
50
Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. (1988704)
1991

Variations for Soft Tissue Sarcoma

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Expression for genes affiliated with Soft Tissue Sarcoma

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Search GEO for disease gene expression data for Soft Tissue Sarcoma.

Pathways for genes affiliated with Soft Tissue Sarcoma

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Pathways related to Soft Tissue Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NME1, ABCB1
29.9ABCB1, NME1
39.9NME1, IL2RA
49.7MDM2, NME1, ABCB1
5
Show member pathways
9.5IL2RA, MDM2, FGFR4
69.3MDM2, MIR34A, ABCB1
79.2FGFR4, MDM2, IL2RA, HLA-G

Compounds for genes affiliated with Soft Tissue Sarcoma

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Compounds related to Soft Tissue Sarcoma according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1sestamibi4310.3MKI67, ABCB1
2gluten4310.2IL2RA, HLA-G
3vinorelbine43 49 1212.1MKI67, ABCB1
4chi 24310.1MDM2, NME1, MKI67
5p000014310.1MDM2, MKI67
6trimetrexate43 1211.1ABCB1, FPGS
7ranitidine43 28 24 1213.1ABCB1, IL2RA
8irinotecan43 49 1212.0MDM2, MKI67, ABCB1
9ponatinib49 1211.0FGFR4, ABCB1
10p0024310.0MKI67, NME1, MDM2
11p0034310.0MDM2, MKI67, HLA-G
12lamivudine43 49 1212.0NME1, IL2RA, ABCB1
13dutp4310.0MDM2, MKI67
14mifepristone43 28 59 1212.9ABCB1, MKI67, IL2RA
152-chlorodeoxyadenosine439.9IL2RA, MDM2
16sn 3843 5910.9FPGS, ABCB1
17camptothecin43 59 1211.9MDM2, XRCC2, ABCB1
18quinidine43 28 49 1212.8MKI67, ABCB1
19vincristine43 49 1211.8MDM2, IL2RA, MKI67, ABCB1
20cyclophosphamide43 49 1211.7ABCB1, MKI67, IL2RA, MDM2
21etoposide43 49 59 1212.7MDM2, NME1, IL2RA, ABCB1
22folate439.7MKI67, IL2RA, FPGS
23paclitaxel43 49 1211.7ABCB1, MKI67, IL2RA, MDM2
24doxorubicin43 49 1211.7MDM2, IL2RA, MKI67, ABCB1
25epinephrine43 24 1211.7IL2RA, MKI67, ABCB1
26thymidylate439.6ABCB1, MKI67, FPGS, MDM2
27testosterone43 59 24 1212.6ABCB1, MKI67, IL2RA, MDM2
28steroid439.5MKI67, IL2RA, NME1, MDM2
29progesterone43 28 59 24 1213.5ABCB1, HLA-G, MKI67, NME1, MDM2
30dexamethasone43 49 28 1212.4ABCB1, HLA-G, IL2RA, NME1, MDM2
315-aza-2deoxycytidine439.4HLA-G, MDM2, CTAG1B
32paraffin439.4MKI67, IL2RA, NME1, MDM2, FGFR4
33thymidine43 2410.3MKI67, IL2RA, FPGS, NME1, MDM2
34mitomycin c439.3ABCB1, MKI67, XRCC2, FPGS, MDM2
35Adenosine triphosphate24 1210.1ABCB1, FPGS, NME1, MDM2, FGFR4
36cisplatin43 49 59 1212.1ABCB1, MKI67, XRCC2, IL2RA, NME1, MDM2
37vegf439.1HLA-G, MKI67, IL2RA, NME1, MDM2, FGFR4
385fluorouracil439.1ABCB1, MKI67, IL2RA, FPGS, NME1, MDM2
39methotrexate49 43 1211.0MDM2, FPGS, IL2RA, MKI67, HLA-G, ABCB1
40arginine438.9FGFR4, MDM2, IL2RA, MKI67

GO Terms for genes affiliated with Soft Tissue Sarcoma

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Biological processes related to Soft Tissue Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1organ regenerationGO:00311009.8FPGS, MKI67
2negative regulation of T cell proliferationGO:00421309.6IL2RA, HLA-G

Molecular functions related to Soft Tissue Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00055248.4FGFR4, NME1, FPGS, XRCC2, MKI67, ABCB1

Products for genes affiliated with Soft Tissue Sarcoma

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Sources for Soft Tissue Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet