MCID: SFT003
MIFTS: 32

Soft Tissue Sarcoma malady

Cancer diseases category

Summaries for Soft Tissue Sarcoma

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your soft tissues connect, support, or surround other tissues. examples include your muscles, tendons, fat, and blood vessels. soft tissue sarcoma is a cancer of these soft tissues. there are many kinds, based on the type of tissue they started in. they may cause a lump or swelling in the soft tissue. sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. no one knows exactly what causes these cancers. they are not common, but you have a higher risk if you have been exposed to certain chemicals, have had radiation therapy, or have certain genetic diseases. doctors diagnose soft tissue sarcomas with a biopsy. treatments include surgery to remove the tumor, radiation therapy, chemotherapy, or a combination. nih: national cancer institute

MalaCards: Soft Tissue Sarcoma is related to sarcoma and rhabdomyosarcoma. An important gene associated with Soft Tissue Sarcoma is MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase), and among its related pathways are Akt Signaling and Rho Family GTPases. The compounds 5fluorouracil and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and tumorigenesis.

Wikipedia:63 A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is... more...

Aliases & Classifications for Soft Tissue Sarcoma

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Sources:
42NIH Rare Diseases, 33MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

soft tissue sarcoma 42 33


Related Diseases for Soft Tissue Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Soft Tissue Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma32.3KIT, MVP, FAP, CTAG1B, MDM2, MKI67
2rhabdomyosarcoma31.1ABCB1, MDM2, MVP
3melanoma30.9MVP, FAP, CTAG1B, HLA-G, MDM2, PRAME
4synovial sarcoma30.7CTAG1B, MDM2, MKI67, KIT
5breast cancer30.7MVP, FAP, CTAG1B, HLA-G, MDM2, MKI67
6leukemia30.5MVP, CSF3, CTAG1B, HLA-G, MDM2, PRAME
7ovarian cancer30.5MVP, FAP, HLA-G, MDM2, ABCB1, NME1
8osteosarcoma30.5MVP, MDM2, ABCB1, NME1
9retinoblastoma30.5NME1, MKI67, MDM2, HLA-G
10leiomyosarcoma30.5MVP, MDM2, KIT
11malignant peripheral nerve sheath tumor30.5KIT, ABCB1, MDM2
12liposarcoma30.5MDM2, MVP
13acute leukemia30.4MVP, CSF3, HLA-G, PRAME, ABCB1, KIT
14gastrointestinal stromal tumor30.4MKI67, KIT
15myeloma30.1MVP, CSF3, CTAG1B, HLA-G, ABCB1
16colorectal cancer30.1NME1, ABCB1, MKI67, MDM2, MVP
17myeloid leukemia30.1KIT, NME1, ABCB1, CSF3
18multiple myeloma30.1CSF3
19neuroblastoma30.1NME1
20clear cell sarcoma30.1LATS1
21pleomorphic liposarcoma30.1KIT, MDM2
22chondrosarcoma30.1MDM2
23retroperitoneal sarcoma10.7
24breast sarcoma10.5
25fibrous histiocytoma10.5
26histiocytoma10.5
27embryonal rhabdomyosarcoma10.4
28alveolar soft part sarcoma10.4
29epithelioid sarcoma10.4
30hemangiopericytoma10.4
31dermatofibrosarcoma protuberans10.4
32dermatofibrosarcoma10.3
33alveolar rhabdomyosarcoma10.3
34brain sarcoma10.3
35bladder sarcoma10.3
36myxoid liposarcoma10.3
37anaplastic large cell lymphoma10.3
38li-fraumeni syndrome10.3
39lung sarcoma10.3
40skin sarcoma10.3
41thyroid sarcoma10.3
42thyroiditis10.3
43desmoplastic small round cell tumor10.3
44neurofibromatosis10.2
45hypercalcemia10.2
46dendritic cell sarcoma10.2
47fasciitis10.2
48hemangioma10.2
49hodgkin's lymphoma10.2
50prostate rhabdomyosarcoma10.2

Graphical network of the top 20 diseases related to Soft Tissue Sarcoma:



Diseases related to soft tissue sarcoma

Clinical Features for Soft Tissue Sarcoma

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Drugs & Therapeutics for Soft Tissue Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Soft Tissue Sarcoma

Drug clinical trials:

Search ClinicalTrials for Soft Tissue Sarcoma

Search NIH Clinical Center for Soft Tissue Sarcoma

Search CenterWatch for Soft Tissue Sarcoma

Genetic Tests for Soft Tissue Sarcoma

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Anatomical Context for Soft Tissue Sarcoma

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Animal Models for Soft Tissue Sarcoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Soft Tissue Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.1PATZ1, TUSC2, CSF3, HLA-G, MDK, MDM2
2MP:000200610.9MDM2, ING2, IL12A, NME1, KIT, LATS1
3MP:000538710.9MDK, HLA-G, CSF3, TUSC2, MDM2, ING2

Publications for Soft Tissue Sarcoma

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Genetic Variations for Soft Tissue Sarcoma

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Expression for genes affiliated with Soft Tissue Sarcoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Soft Tissue Sarcoma

Search GEO for disease gene expression data for Soft Tissue Sarcoma.

Pathways for genes affiliated with Soft Tissue Sarcoma

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51QIAGEN, 29KEGG
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Pathways related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9IL12A, IL2RA, MDM2, MDK, CSF3, KIT
2
Hide members
10.9IL12A, IL2RA, MDM2, MDK, CSF3, KIT
3
Hide members
10.8CSF3, MDK, IL2RA, IL12A, KIT
410.7IL2RA, MDM2, HLA-G, KIT
510.7KIT, IL2RA, CSF3

Compounds for genes affiliated with Soft Tissue Sarcoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
15fluorouracil4411.5KIT, MVP, CSF3, MDM2, MKI67, IL2RA
2vegf4411.4MVP, CSF3, HLA-G, MDM2, MKI67, IL2RA
3methotrexate44 49 1113.4CSF3, HLA-G, MDM2, MKI67, IL2RA, ABCB1
4vincristine44 49 1113.4MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
5doxorubicin44 49 1113.4MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
6cisplatin44 49 59 1114.4MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
7progesterone44 59 28 11 2415.4MVP, HLA-G, MDM2, MKI67, ABCB1, NME1
8cyclophosphamide44 49 1113.3MVP, CSF3, MDM2, MKI67, IL2RA, ABCB1
9etoposide44 49 59 1114.3MVP, CSF3, MDM2, IL2RA, ABCB1, NME1
10paraffin4411.3MVP, MDM2, MKI67, IL2RA, NME1, KIT
11thymidine44 2412.3CSF3, MDM2, MKI67, IL2RA, NME1, KIT
12irinotecan44 49 1113.2CSF3, MDM2, MKI67, ABCB1, KIT
13p0034411.2MVP, HLA-G, MDM2, MKI67, KIT
14mitomycin c4411.2ABCB1, MKI67, MDM2, CSF3, MVP
15p0024411.2MVP, MDM2, MKI67, NME1, KIT
16docetaxel44 49 59 1114.2KIT, ABCB1, MDM2, CSF3, MVP
17paclitaxel44 49 1113.2MVP, CSF3, MDM2, ABCB1
18epinephrine44 11 2413.2MVP, CSF3, MKI67, IL2RA, ABCB1
192-chlorodeoxyadenosine4411.2CSF3, MDM2, IL2RA, KIT
20mycophenolate mofetil44 49 1113.2CSF3, IL2RA, IL12A, ABCB1
21melphalan44 1112.1MVP, CSF3, MDM2, ABCB1
22daunorubicin44 49 1113.1MVP, CSF3, MDM2, ABCB1
23vinblastine44 49 1113.1MVP, CSF3, MDM2, ABCB1
24cytarabine44 49 1113.1KIT, ABCB1, CSF3, MVP
25thymidylate4411.1ABCB1, MKI67, MDM2, MVP
26prednisolone44 28 1113.1MVP, CSF3, IL2RA, ABCB1
27adriamycin4411.1MVP, CSF3, MDM2, ABCB1
28chi 24411.1MDM2, MKI67, NME1
29idarubicin44 49 1113.1ABCB1, CSF3, MVP
30rhodamine 12344 4912.0KIT, ABCB1, MVP
31vinorelbine44 1112.0CSF3, MKI67, ABCB1
32imatinib44 49 1113.0CSF3, MDM2, ABCB1, KIT
33lamivudine44 1112.0IL2RA, ABCB1, NME1
34gramicidin d44 1112.0MVP, ABCB1
35dexamethasone44 49 28 1113.9NME1, ABCB1, MDM2
36r 1234410.9MVP, ABCB1
37daunoxome4410.9CSF3, ABCB1
38mitoxantrone44 49 1112.9MVP, CSF3, ABCB1
39pirarubicin4410.9ABCB1, CSF3
40sestamibi4410.8ABCB1
41acnu4410.8ABCB1, CSF3
42carbimazole44 1111.8IL2RA, CSF3
43nilotinib49 1111.8ABCB1, KIT
44p-0074410.8MKI67, KIT
45carboplatin44 49 1112.7CSF3, MDM2, ABCB1
46gluten4410.7HLA-G, IL2RA
47gefitinib44 49 1112.7MDM2, ABCB1, KIT
48homoharringtonine44 1111.6ABCB1, CSF3
49estrogen4410.4MVP
50bleomycin44 1111.4IL2RA, CSF3, MVP

GO Terms for genes affiliated with Soft Tissue Sarcoma

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Sources:
16Gene Ontology
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Biological processes related to Soft Tissue Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell differentiationGO:04558210.6IL12A, IL2RA

Products for genes affiliated with Soft Tissue Sarcoma

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Soft Tissue Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet