Soft Tissue Sarcoma malady

MedlinePlus: Your soft tissues connect, support or surround other tissues. examples include your muscles, tendons, fat and blood vessels. soft tissue sarcoma is a cancer of these soft tissues. there are many kinds, based on the type of tissue they started in. sometimes they spread and can press on nerves and organs, causing problems such as pain or trouble breathing. no one knows exactly what causes these cancers. they are not common, but you have a higher risk if you have been exposed to certain chemicals, had radiation therapy or have certain genetic diseases. to diagnose soft tissue sarcomas, doctors must remove and look at a piece of the tumor under a microscope. treatments include surgery to remove the tumor, radiation therapy, chemotherapy or a combination. nih: national cancer institute²³

MalaCards: Soft Tissue Sarcoma, also known as sarcoma, is related to kaposi's sarcoma and epithelioid sarcoma. An important gene associated with Soft Tissue Sarcoma is LATS1 (LATS, large tumor suppressor, homolog 1 (Drosophila)), and among its related pathways are Pancreatic cancer and Actin-Based Motility by Rho Family GTPases. The drugs ifosfamide and bleomycin and the compounds sp 600125 and atp have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and whole blood, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is...⁴⁴ more...

soft tissue sarcoma 30 17 23 sarcoma 43

Diseases related to soft tissue sarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1101)

id	Related Disease	Score	Top Affiliating Genes
1	kaposi's sarcoma	37.6	VEGFA, VEGFC, KDR, CFLAR, CDK6, FLT4
2	epithelioid sarcoma	34.6	KITLG, VIM, MVP, MTOR, S100B, JUP
3	peripheral primitive neuroectodermal tumor	34.2	KIT, KITLG, RB1, BCL2, BCL2L1, MTOR
4	endometrial stromal sarcoma	33.2	KIT, PCNA, VIM, BCL2, S100B, ESR1
5	spindle cell sarcoma	32.6	VIM, S100B, FLT4, NTRK3, DES
6	desmoplastic small round cell tumor	32.4	KIT, VIM, MYOG, MYOD1, BMP4, PAX7
7	synovial sarcoma	32.4	KIT, VIM, RARA, RASSF1, BCL2, S100B
8	uterine sarcoma	32.3	KIT, MYC, KDR, CDKN2A, MLH1, MKI67
9	dermatofibrosarcoma protuberans	32.2	KIT, VIM, S100B, MMP2, TP53, PTGS2
10	botryoid rhabdomyosarcoma	32.1	MYOG, MYOD1, PAX7, PAX3, FOXO1, WT1
11	embryonal sarcoma	31.9	KIT, SERPINA3, VIM, MYOG, MYOD1, S100B
12	kidney clear cell sarcoma	31.8	KIT, S100B, IGF2, EWSR1, WT1
13	immunodeficiency	31.8	BLZF1, CFLAR, CD40LG, CD40, MIF, IL10
14	li-fraumeni syndrome	31.7	RB1, BCL2, BAX, MSH2, CDKN1A, CDKN2A
15	classic kaposi sarcoma	31.6	VEGFA, B2M, IL10, IL12A, IFNA1, TNF
16	dermatofibrosarcoma	31.5	KIT, VIM, S100B, MMP2, MDM2, TP53
17	hemangiopericytoma	31.4	RB1, VIM, VEGFA, KDR, S100B, CDH1
18	hodgkin's lymphoma	31.2	BLZF1, BCL2, BCL2L1, CFLAR, FSCN1, CD40
19	alveolar soft part sarcoma	31.1	VIM, MYOG, MYOD1, MLH1, MB, DES
20	malignant fibrous histiocytoma	31.0	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
21	malignant peripheral nerve sheath tumor	30.9	KIT, VIM, MYOG, BMP2, S100B, CDKN2A
22	rhabdoid tumors	30.8	VIM, MYOD1, IGF1R, IGF2, SPP1, SMARCB1
23	histiocytoma	30.6	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
24	fibrous histiocytoma	30.6	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
25	acute lymphoblastic leukemia	30.5	KIT, KITLG, RB1, BCL2, BCL2L1, MVP
26	myxoid chondrosarcoma	30.3	VIM, MTAP, S100B, CDKN2B, CDKN2A, EWSR1
27	sarcoma	30.3	KIT, KITLG, PCNA, GCLC, RB1, RBL2
28	acquired immunodeficiency syndrome	30.2	SERPINA1, RAF1, S100B, B2M, CD40, GSR
29	liposarcoma	29.5	KIT, RB1, VIM, VEGFA, RARA, KDR
30	neuroectodermal tumors	28.9	KIT, KITLG, RB1, VIM, MYC, MYOG
31	lymphoblastic lymphoma	28.9	VIM, MYC, BCL2, CDK6, CDKN1A, CDKN2B
32	castleman's disease	28.8	VEGFA, B2M, FSCN1, IL10, IL6, IFNA1
33	hypercalcemia	28.8	VIM, VDR, B2M, FGF2, IL2, IL3
34	inflammatory myofibroblastic tumor	28.6	VIM, CDK4, MKI67, ALK, PTGS2, SYNM
35	myelodysplastic syndrome	28.6	KIT, KITLG, VDR, RARA, BIRC5, MVP
36	neurofibromatosis	28.4	KIT, KITLG, RAF1, BLZF1, S100B, MSH2
37	squamous cell carcinoma	27.8	CD44, CDH1, MKI67, GSTP1, CCNA2, PTHLH
38	primary effusion lymphoma	27.8	VEGFA, VDR, MYC, BIRC5, BCL2, BAX
39	hemangioendothelioma	27.6	VEGFA, KDR, S100B, FLT4, FGF2, IL2
40	renal cell carcinoma	27.5	KIT, PCNA, VIM, VEGFA, VEGFC, RARB
41	mesenchymal chondrosarcoma	27.3	VIM, MYOG, MYOD1, S100B, SMARCB1, SYNM
42	breast cancer	27.3	MYC, CDK6, CDK4, CDH1, IGF1R, IFI27
43	colorectal cancer	27.3	VDR, MYCL1, MSH2, MLH1, GSTM1, GSTP1
44	anaplastic large cell lymphoma	27.2	KIT, PCNA, RB1, SERPINA1, SERPINA3, MYC
45	perineurioma	27.1	KIT, VIM, S100B, NF2, PDGFRA, DES
46	non-hodgkin lymphoma	27.1	KITLG, VDR, MYC, MYOD1, BIRC5, BCL2
47	nephroblastoma	27.1	KIT, VIM, VEGFC, BMP2, PAX3, MVP
48	mastocytosis	27.0	KIT, KITLG, VIM, RARA, BCL2, BCL2L1
49	congenital mesoblastic nephroma	27.0	VIM, MDM2, IGF2, NTRK3, SMARCB1, WT1
50	myelofibrosis	26.9	KIT, KITLG, VEGFA, BMP2, RARB, KDR

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bleomycin, bleomycin sulfate, doxorubicin hydrochloride, ifosfamide, mitoxantrone, mitoxantrone hydrochloride, thiotepa

MalaCards organs/tissues related to soft tissue sarcoma:

²²

MGI Mouse Phenotypes related to soft tissue sarcoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	11.0	MYOG, MYOD1, PAX7, PAX3, LGR5, LDHA
2	craniofacial phenotype	MP:0005382	11.0	KIT, KITLG, BMP4, PAX7, PAX3, LGR5
3	endocrine/exocrine gland phenotype	MP:0005379	10.6	RBL2, PAX7, PAX3, PATZ1, LGR5, LATS1
4	hematopoietic system phenotype	MP:0005397	10.5	KIT, PCNA, SEMA4D, BMP4, PAX3, PATZ1
5	normal phenotype	MP:0002873	9.8	GCLC, RBL2, VEGFA, MYC, MYCL1, MYOG
6	embryogenesis phenotype	MP:0005380	9.7	KIT, GCLC, RBL2, VIM, MYC, MYOG
7	immune system phenotype	MP:0005387	9.6	KIT, VIM, VDR, RARA, RAF1, PAX7
8	other phenotype	MP:0005395	9.4	RARA, RARB, KDR, CDKN2A, CD40LG, IL2
9	renal/urinary system phenotype	MP:0005367	9.2	KIT, SEMA4D, BMP4, RARA, RARB, PAX3
10	liver/biliary system phenotype	MP:0005370	9.2	KIT, GCLC, VEGFA, BMP4, MTAP, SAV1
11	mortality/aging	MP:0010768	9.2	KITLG, GCLC, RB1, RBL2, SERPINE1, VEGFA
12	no phenotypic analysis	MP:0003012	9.1	PCNA, RB1, RBL2, VEGFA, MYC, MYOD1
13	pigmentation phenotype	MP:0001186	9.1	KIT, KITLG, RB1, MYC, PAX3, BCL2
14	nervous system phenotype	MP:0003631	9.0	KIT, KITLG, RB1, RBL2, SEMA4D, SEMA3F
15	integument phenotype	MP:0010771	8.9	KIT, KITLG, RB1, RBL2, MYC, MYOG
16	hearing/vestibular/ear phenotype	MP:0005377	8.7	KIT, KITLG, RB1, VDR, MYC, BMP2
17	limbs/digits/tail phenotype	MP:0005371	8.3	KIT, KITLG, RB1, RBL2, VEGFA, VDR
18	reproductive system phenotype	MP:0005389	8.0	RBL2, VEGFA, VDR, MYOD1, BMP2, RARA
19	growth/size phenotype	MP:0005378	7.9	KIT, KITLG, GCLC, RB1, RBL2, SEMA3F
20	digestive/alimentary phenotype	MP:0005381	7.4	KIT, KITLG, RB1, VEGFA, VDR, MYC
21	behavior/neurological phenotype	MP:0005386	7.1	KIT, RB1, SEMA4D, VIM, MYOG, BMP4
22	adipose tissue phenotype	MP:0005375	6.9	RB1, SERPINE1, MYC, MYOG, MYOD1, BCL2
23	vision/eye phenotype	MP:0005391	6.0	KIT, KITLG, RB1, RBL2, VIM, VEGFA
24	skeleton phenotype	MP:0005390	4.9	KIT, KITLG, RB1, RBL2, VEGFA, VDR
25	homeostasis/metabolism phenotype	MP:0005376	4.6	KIT, KITLG, RB1, RBL2, SERPINE1, VIM
26	tumorigenesis	MP:0002006	4.3	KIT, KITLG, RB1, RBL2, SERPINE1, MYC
27	cellular phenotype	MP:0005384	3.9	KIT, KITLG, PCNA, GCLC, RB1, RBL2
28	cardiovascular system phenotype	MP:0005385	3.4	KIT, KITLG, RB1, RBL2, SEMA4D, SERPINE1
29	muscle phenotype	MP:0005369	3.2	KIT, RB1, RBL2, VIM, VEGFA, MYC

Articles related to soft tissue sarcoma:

(show top 50)    (show all 278)

id	Title	Authors	Year	Affiliating Genes
1	The prognostic impact of TGF-I^1, fascin, NF-I_B and PK C-IP expression in soft tissue sarcomas. (21390241)	Valkov A.... Busund L.T.	2011	TGFB1, NFKB1, PRKCZ
2	Estrogen receptor and progesterone receptor are progn ostic factors in soft tissue sarcomas. (21271213)	Valkov A.... Busund L.T.	2011	PGR, ESR1, ESR2
3	Molecular characterization of an EWSR1-POU5F1 fusion associated with a t(6;22) in an undifferentiated soft tissue sarcoma. (21962892)	Deng F.M.... Stein C.K.	2011	EWSR1
4	Frequent concomitant inactivation of miR-34a and miR- 34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelia l, and renal cell carcinomas and soft tissue sarcomas. (21225432)	Vogt M.... Hermeking H.	2011	TP53, MIR34A
5	Frequent absence of tumor suppressor FUS1 protein exp ression in human bone and soft tissue sarcomas. (21273575)	Li G.... Endo N.	2011	TUSC2
6	Elevated tumor and serum levels of the hypoxia-associ ated protein osteopontin are associated with prognosis for soft tissue sarcoma patients. (20377868)	Bache M.... Vordermark D.	2010	SPP1
7	Pre-treatment serum levels of interleukin-10, interle ukin-12 and their ratio predict response to therapy and probability of event-fr ee and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias. (19376105)	Bien E.... Stepinski J.	2009	IL10, IL12A
8	Epidermal growth factor receptor blockade in combination with conventional chemotherapy inhibits soft tissue sarcoma cell growth in vitro and in vivo. (18451246)	Ren W.... Lev D.	2008	EGFR, EGF
9	Down-regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis. (18507004)	Kanazawa Y.... Tsuchiya H.	2008	JUP
10	Aberrant expression of the Rb pathway proteins in soft tissue sarcomas. (17122635)	Sabah M.... Kay E.	2006	RB1, CDK6
11	Phase I/II study of docetaxel, ifosfamide, and doxoru bicin in advanced, recurrent, or metastatic soft tissue sarcoma (STS). (16791410)	Suppiah R.... Budd G.T.	2006	CSF3
12	Wild-type p53 inhibits nuclear factor-kappaB-induced matrix metalloproteinase-9 promoter activation: implications for soft tissue sarcoma growth and metastasis. (17077165)	Liu J.... Lev D.	2006	TP53, MMP9
13	Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. (16144921)	Weng W.H.... Larsson C.	2005	EZR
14	Prognostic significance of augmented metallothionein (MT) expression correlated with Ki-67 antigen expression in selected soft tissue sarcomas. (15578426)	Dziegiel P.... Zabel M.	2005	MKI67
15	Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma. (15671548)	Ahlen J.... Larsson C.	2005	IGF1R
16	Multidrug resistance proteins in primary and metastatic soft-tissue sarcomas: down-regulation of P-glycoprotein during metastatic progression. (15015610)	Komdeur R.... van der Graaf W.T.	2004	ABCC1, ABCB1, MVP
17	Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. (12738717)	Kuenen B.C.... Harris A.L.	2003	VEGFA
18	Trail-induced apoptosis and interaction with cytotoxic agents in soft tissue sarcoma cell lines. (12763223)	Tomek S.... Krainer M.	2003	CASP8, TNFRSF10B, TNFSF10
19	Isolated limb perfusion with tumor necrosis factor-al pha and melphalan for patients with unresectable soft tissue sarcoma of the ext remities. (14508836)	Noorda E.M.... Kroon B.B.	2003	TNF, IFNG
20	UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. (12881716)	Modena P.... Sozzi G.	2003	EWSR1, UQCRH, PATZ1
21	Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma. (14601095)	Morimoto Y.... Inoue H.	2003	FGFR4
22	Improved antitumor response to isolated limb perfusion with tumor necrosis factor after upregulation of endothelial monocyte-activating polypeptide II in soft tissue sarcoma. (12374666)	Lans T.E.... Eggermont A.M.	2002	TNF, AIMP1
23	Telomerase activity and hTERT mRNA expression can be heterogeneous and does not correlate with telomere length in soft tissue sarcomas. (11948462)	Yan P.... Guillou L.	2002	TERT
24	High bad and bcl-xL gene expression and combined bad, bcl-xL, bax and bcl-2 mRNA levels: molecular predictors for survival of stage 2 soft tissue sarcoma patients. (12168836)	Kohler T.... Taubert H.	2002	GAPDH, BCL2L1
25	Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. (11308256)	Nordsmark M.... Overgaard J.	2001	TP53
26	Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade. (11314944)	Chao C.... Eisenberg B.	2001	VEGFA
27	Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas. (10705392)	Yoo J.... Robinson R.A.	2000	TERC
28	(F-18) fluorodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcoma. (10778952)	Folpe A.L.... Eary J.F.	2000	MIB1
29	A MboII polymorphism in exon 11 of the human MDM2 gene occuring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility? (11087894)	Taubert H.... Wuerl P.	2000	MDM2
30	Expression of P53, MDM2 and Ki-67 antigens in soft tissue sarcomas. (10412269)	Szadowska A.... Debiec-Rychter M.	1999	MDM2, TP53, MKI67
31	Stem cell factor is not essential for cell survival and proliferation of soft tissue sarcoma of neuroectodermal origin. (10509034)	Ricotti E.... Basso G.	1999	KIT, KITLG
32	p53 status in radiation-induced soft-tissue sarcomas. (9739384)	Taubert H.... WA1rl P.	1998	TP53
33	Significance of differential nuclear expression of Ki-67 in adult soft tissue sarcomas (10095458)	Rohr U.P.... Bohle R.M.	1998	MKI67
34	Epidermal growth factor receptor and insulin-like growth factor-I receptor expression and function in human soft-tissue sarcoma cells. (9458358)	Beech D.... Radinsky R.	1998	MET, IGF1R, EGFR
35	Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma. (9690542)	Heslin M.J.... Brennan M.F.	1998	MDM2, MKI67
36	Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. (9675593)	Jensen V.... Jensen O.M.	1998	BCL2
37	Overexpression of cyclin D1 is associated with poor prognosis in extremity soft-tissue sarcomas. (9796968)	Kim S.H.... Cordon-Cardo C.	1998	CCNG1
38	Isolation limb perfusion with tumor necrosis factor a lpha and chemotherapy for advanced extremity soft tissue sarcomas. (9344321)	Eggermont A.M.... Lejeune F.J.	1997	IFNG
39	Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms. (18521197)	Pollock R.E.... Hung M.C.	1997	MDM2
40	Anti-tumor activity of CPT-11 in experimental human o varian cancer and human soft-tissue sarcoma. (9399672)	Jansen W.J.... Boven E.	1997	TOP1
41	Tumor-induced hypercalcemia in a patient with extensive soft tissue sarcoma: effects of bisphosphonate therapy and surgery. (8888806)	Oleffe V.... Body J.J.	1996	PTHLH
42	Comparative genomic hybridization analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas. (8527390)	Forus A.... van Kessel A.G.	1995	CDK4, MDM2
43	Efficacy of the tumor necrosis factor-alpha (rTNF-alpha) associated with interferon-gamma and chemotherapy in extracorporeal circulation in the limb in inoperable malignant melanoma, soft tissue sarcoma and epidermoid carcinoma. A 4-year experience (7549119)	Lejeune F.... Schmitz P.	1995	TNF, IFNG
44	Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate. (9816025)	Li W.W.... Bertino J.R.	1995	TYMS, DHFR, FPGS
45	Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. (7904171)	Stein U.... Schmidt-Peter P.	1993	ABCB1
46	p53 Mutation and MDM2 amplification in human soft tissue sarcomas. (8387391)	Leach F.S.... Vogelstein B.	1993	MDM2, TP53
47	Chordomalike soft tissue sarcoma in the leg: a light and electron microscopic and immunohistochemical study. (1440978)	Miettinen M.... Lackman R.	1992	KRT8
48	Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. (1988704)	Wunder J.S.... Andrulis I.L.	1991	RB1
49	Cell marker studies in undifferentiated soft tissue sarcoma. (1752649)	Madhavan M.... Krishnan K.B.	1991	SERPINA1, VIM, DES
50	Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene. (2216456)	Stratton M.R.... Gusterson B.A.	1990	RB1, TP53

Genes related to soft tissue sarcoma according to GeneCards:

(show top 50)    (show all 205)

id	Symbol	Description	Score	GeneCards Section Context
1	LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	11.1	Summaries, Publications
2	FAP	fibroblast activation protein, alpha	11.1	Summaries
3	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
4	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
5	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
6	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
7	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
8	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
9	MIR34A	microRNA 34a	11.0	Publications
10	IRX2	iroquois homeobox 2	11.0	Publications
11	TUSC2	tumor suppressor candidate 2	11.0	Publications
12	UQCRH	ubiquinol-cytochrome c reductase hinge protein	11.0	Publications
13	ING2	inhibitor of growth family, member 2	11.0	Publications
14	MDK	midkine (neurite growth-promoting factor 2)	11.0	Publications
15	MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	11.0	Publications
16	SLC22A18	solute carrier family 22, member 18	11.0
17	PATZ1	POZ (BTB) and AT hook containing zinc finger 1	11.0	Publications
18	SYNM	synemin, intermediate filament protein	11.0	Publications
19	PRAME	preferentially expressed antigen in melanoma	11.0	Publications
20	SAV1	salvador homolog 1 (Drosophila)	11.0	Publications
21	SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	11.0	Publications
22	CCNG1	cyclin G1	11.0	Publications
23	PIWIL1	piwi-like 1 (Drosophila)	11.0	Publications
24	EREG	epiregulin	11.0	Publications
25	NKD2	naked cuticle homolog 2 (Drosophila)	11.0	Publications
26	CTAG1B	cancer/testis antigen 1B	11.0	Publications
27	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
28	FPGS	folylpolyglutamate synthase	11.0	Publications
29	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Publications
30	CTSS	cathepsin S	11.0	Publications
31	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0	Publications
32	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	11.0	Publications
33	MYOG	myogenin (myogenic factor 4)	11.0	Publications
34	MYOD1	myogenic differentiation 1	11.0	Publications
35	MVP	major vault protein	11.0	Publications
36	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	11.0	Publications
37	LDHA	lactate dehydrogenase A	11.0	Publications
38	CSPG4	chondroitin sulfate proteoglycan 4	11.0	Publications
39	CASC4	cancer susceptibility candidate 4	11.0	Publications
40	AIMP1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	11.0	Publications
41	CA9	carbonic anhydrase IX	11.0	Publications
42	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
43	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
44	FOXO1	forkhead box O1	11.0	Publications
45	FGFR4	fibroblast growth factor receptor 4	11.0	Publications
46	MTAP	methylthioadenosine phosphorylase	11.0	Publications
47	CDK4	cyclin-dependent kinase 4	11.0	Publications
48	STK4	serine/threonine kinase 4	11.0	Publications
49	SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	11.0	Publications
50	ANGPT2	angiopoietin 2	11.0	Publications

Pathways related to soft tissue sarcoma according to GeneDecks:

(show top 50)    (show all 236)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.9	CDK6
2	Actin-Based Motility by Rho Family GTPases36	10.8	BMP4, FGFR4, IL2
3	Glioma Invasiveness36	10.7	KITLG, VEGFC, BMP2, BMP4, CD44, FGF2
4	Glioblastoma Multiforme36	10.2	RB1, RAF1, CDK6, CDKN1A, CDK4, FOXO1
5	PTEN Pathway36	9.9	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
6	Endometrial cancer20	9.9	MYC, RAF1, CDH1, MLH1, HRAS, ERBB2
7	p53 signaling pathway20	9.8	SERPINE1, BAX, CDK6, CDKN1A, CDKN2A, CDK4
8	CREB Pathway36	9.8	KIT, KITLG, BMP2, BMP4, KDR, FLT4
9	Non-small cell lung cancer20	9.6	RB1, RAF1, RASSF1, CDK6, CDKN2A, CDK4
10	Breast Cancer Regulation by Stathmin136	9.5	BMP2, BMP4, RAF1, FGF2, FGFR4, MAPK10
11	Akt Signaling36	9.3	KIT, VEGFC, BMP2, BMP4, RAF1, FOXO1
12	eIF2 Pathway36	9.2	KIT, KITLG, VEGFC, BMP4, RAF1, FLT4
13	Glioma20	9.1	RB1, RAF1, MTOR, CDK6, CDKN1A, CDKN2A
14	P2Y Receptor Signaling36	9.1	KIT, VEGFC, MYC, RAF1, KDR, FLT4
15	Paxillin Interactions36	9.1	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
16	Rac1 Pathway36	9.1	KITLG, BMP4, RAF1, KDR, FLT4, FGF2
17	ERK5 Signaling36	8.9	KIT, KITLG, VEGFC, MYC, BMP2, BMP4
18	Telomerase Components in Cell Signaling36	8.8	KIT, KITLG, RB1, VEGFC, MYC, BMP2
19	PPAR Pathway36	8.8	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
20	MIF Mediated Glucocorticoid Regulation36	8.7	BMP2, BMP4, BCL2, BAX, MIF, IL10
21	Nuclear Receptor Activation by Vitamin-A36	8.7	KIT, KITLG, VEGFC, BMP2, BMP4, RARA
22	JNK Pathway36	8.6	KIT, KITLG, BMP2, BMP4, RAF1, KDR
23	Apoptotic Pathways in Synovial Fibroblasts36	8.5	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
24	MIF Regulation of Innate Immune Cells36	8.4	BMP2, BMP4, BCL2, BAX, MIF, IL10
25	ILK Signaling36	8.4	KIT, KITLG, VIM, VEGFC, BMP2, BMP4
26	p53 Mediated Apoptosis36	8.4	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
27	Rho Family GTPases36	8.4	KIT, KITLG, VIM, VEGFC, BMP2, BMP4
28	DHA Signaling36	8.4	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
29	Bladder cancer20	8.3	RB1, VEGFA, VEGFC, MYC, RAF1, RASSF1
30	Rap1 Pathway36	8.1	KITLG, VEGFC, BMP2, BMP4, RAF1, FGF2
31	STAT3 Pathway36	8.1	MYC, BMP2, BMP4, RAF1, BCL2, BAX
32	Activation of PKC through GPCR36	8.0	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
33	NF-KappaB Family Pathway36	8.0	KITLG, VEGFC, BMP2, BMP4, KDR, FLT4
34	Glucocorticoid Receptor Signaling36	7.9	BMP2, BMP4, BCL2, BAX, CDKN1A, IL10
35	Nanog in Mammalian ESC Pluripotency36	7.8	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
36	cAMP Pathway36	7.8	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
37	Endothelin-1 Signaling Pathway36	7.7	KIT, MYC, BMP2, BMP4, RAF1, FLT4
38	p70S6K Signaling36	7.6	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
39	Phospholipase-C Pathway36	7.6	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
40	GSK3 Signaling36	7.5	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
41	NFAT in Immune Response36	7.5	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
42	Intracellular Calcium Signaling36	7.4	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
43	Antioxidant Action of Vitamin-C36	7.4	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
44	Cellular Apoptosis Pathway36	7.1	KIT, KITLG, VEGFC, BMP2, BMP4, KDR
45	Pathways in cancer20	6.9	RB1, VEGFA, VEGFC, MYC, BMP2, BMP4
46	GPCR Pathway36	6.8	KIT, KITLG, VEGFC, BMP2, BMP4, RAF1
47	ERK Signaling36	6.6	KIT, KITLG, VEGFC, MYC, BMP2, BMP4
48	Colorectal Cancer Metastasis36	6.6	MYC, BIRC5, BCL2L1, BAX, MSH2, CDKN1A
49	MAPK Signaling36	6.6	KIT, KITLG, VEGFC, MYC, BMP2, BMP4
50	Pancreatic Adenocarcinoma36	6.0	KIT, KITLG, RB1, VEGFC, BMP2, BMP4

Compounds related to soft tissue sarcoma according to GeneDecks:

(show top 50)    (show all 456)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.4	CDKN1A, CD40, TP53, CYCS
2	atp32	10.4	KIT, RB1, RBL2, MYOD1, RAD51, BLZF1
3	gnrh32	10.3	KITLG, SERPINE1, VIM, RAF1, LEP, MKI67
4	cyclic amp32 18	11.2	RB1, MYOD1, RARB, KCNH1, CDKN2A, CDK4
5	ns 39832 42	11.1	PCNA, FGF2, MAPK14, CASP9, TNF, TNFRSF1A
6	bleomycin32 9 9	12.1	MVP, XRCC1, CD44, GSTM1, GSTP1, FGF2
7	epinephrine32 9 18 9	13.0	KITLG, LEP, MVP, MMP2, MMP9, GSR
8	arginine32	10.0	SERPINA3, VDR, MYOD1, BMP2, RAD51, RARA
9	polyethylene glycol32	9.9	KITLG, BMP2, CDH1, MB, IGF2, ERBB2
10	h2o232	9.9	KITLG, SERPINA1, RAD51, BLZF1, LEP, CD40
11	dopamine32 9 18 9	12.9	SERPINA3, BMP2, RARB, RAF1, S100B, CDKN2A
12	biotin32 9 18 9	12.8	KITLG, PCNA, RB1, VIM, SAV1, B2M
13	glycogen32 18	10.8	KIT, VIM, MYC, MTOR, S100B, CDK4
14	chloroquine32 34 9 9	12.6	KIT, RAF1, B2M, CDH1, GSR, IL10
15	formaldehyde32 18	10.5	KIT, PCNA, RB1, VIM, BLZF1, S100B
16	noxa32	9.4	BIRC5, BCL2, BCL2L1, BAX, CFLAR, CDKN1A
17	suramin32 9 9	11.1	PCNA, VEGFA, RAF1, KDR, FGF2, MET
18	3,3-diindolylmethane32	9.1	VEGFA, BIRC5, BAX, CFLAR, CDK6, CDKN1A
19	agarose32	9.0	KIT, KITLG, SERPINA1, MYC, BLZF1, BCL2
20	ribonucleic acid32	8.9	KIT, KITLG, VEGFC, MYC, MYOG, BMP2
21	cd 43732	8.8	MYC, RARA, RARB, BCL2, BCL2L1, BAX
22	carboplatin32 34 9 9	11.8	KITLG, RB1, VEGFA, KDR, BCL2, MSH2
23	flavopiridol32 9 9	10.8	KIT, RB1, VEGFA, BIRC5, BCL2, BCL2L1
24	rapamycin32 42	9.7	KIT, KITLG, RB1, VIM, VEGFA, MYOG
25	vitamin a32 9 18 9	11.5	RB1, SERPINA1, SERPINA3, VIM, VDR, MYC
26	agar32	8.5	KITLG, RB1, VIM, RARA, RARB, RASSF1
27	phosphoinositide32	8.3	KIT, VIM, RARA, RAF1, BIRC5, BCL2L1
28	neopterin32	8.3	B2M, CD40LG, CD40, IL10, IL18R1, IL1RN
29	prednisolone32 9 9	10.1	KITLG, MYC, MVP, CD40, CD44, MMP2
30	tacrolimus32 34 9 9	11.1	PCNA, SERPINE1, VDR, MYC, BMP2, RAF1
31	etoposide32 42 9 9	11.1	PCNA, RB1, MYC, RARA, BIRC5, BCL2
32	glutamate32	8.0	PCNA, VIM, VDR, BLZF1, KDR, LEP
33	taxane32	7.8	VEGFA, BIRC5, KDR, BCL2, MTOR, CDKN1A
34	testosterone32 9 18 9	10.8	KIT, KITLG, PCNA, RB1, VIM, VEGFC
35	tgf beta132	7.7	KITLG, RBL2, SERPINE1, VIM, MYOD1, BMP2
36	rantes32	7.6	KITLG, CD40LG, CD40, CD44, MMP9, MIF
37	ag 147832	7.6	SERPINE1, RAF1, MMP2, MMP9, MET, MAPK14
38	adenylate32	7.6	KITLG, SERPINE1, VIM, VDR, MYOG, BMP4
39	cysteine32	7.4	PCNA, GCLC, SERPINA1, SERPINA3, VDR, MYOG
40	ly29400232	7.4	VEGFA, MYOG, RARA, LEP, CFLAR, CD44
41	5-aza-2deoxycytidine32	7.4	KITLG, PCNA, VIM, MYC, MYOD1, RARB
42	troglitazone32 42 9 9	9.9	RB1, SERPINE1, VDR, RARA, BIRC5, BCL2
43	sb 20358032 42	7.9	RB1, VIM, VEGFA, VDR, BMP2, BMP4
44	docetaxel32 34 9 9	9.6	KIT, VEGFA, VDR, MYC, RAF1, BIRC5
45	alanine32	6.1	KITLG, PCNA, RBL2, VDR, MYC, MYOD1
46	curcumin32	6.1	VEGFA, MYC, RAF1, BIRC5, BCL2, BCL2L1
47	indomethacin32 9 9	7.9	PCNA, VIM, MYC, BMP2, RAF1, BIRC5
48	5fluorouracil32	5.7	KIT, KITLG, PCNA, RB1, VEGFA, VDR
49	cisplatin32 34 9 9	8.4	KITLG, PCNA, GCLC, RB1, VEGFA, MYC
50	actinomycin d32	4.3	KIT, KITLG, RB1, SERPINE1, VIM, VEGFA

Cellular components related to soft tissue sarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	9.9	PLAU, PLAUR, ABCB1, TIMP2, TGFB1, CXCR4
2	plasma membrane	GO:005886	7.7	NRAS, PLAU, PLAUR, NF2, PDGFRA, KRAS
3	extracellular region	GO:005576	7.5	PTHLH, TNFSF10, TNFRSF1A, EREG, ESR2, IFNG
4	cytosol	GO:005829	7.4	CDK4, FPGS, FOXO1, GSR, GSTM1, GSTP1
5	nucleoplasm	GO:005654	7.2	PML, MAPK14, CDKN2A, RB1, MAPK10, MDM2
6	extracellular space	GO:005615	7.0	PECAM1, TNFRSF1A, TNF, EREG, AIMP1, ICAM1
7	nucleus	GO:005634	6.9	GADD45A, WRN, PGR, NME1, PML, PRAME
8	cytoplasm	GO:005737	6.7	BLZF1, TP53, RASSF1, RAF1, RARB, RARA

Biological processes related to soft tissue sarcoma according to GeneDecks:

(show top 50)    (show all 56)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of epithelial cell proliferation	GO:050680	10.9	SAV1, RB1, CDKN1C, TGFB1, PTEN, EREG
2	activation of MAPKK activity	GO:000186	10.7	NRAS, BMP4, RAF1
3	germ cell development	GO:007281	10.5	WT1, ERCC1, MSH2, MTOR, CXCR4, BCL2L1
4	positive regulation of DNA replication	GO:045740	10.5	PDGFRA, EREG, IL3, MET, KITLG, IGF1R
5	phosphatidylinositol-mediated signaling	GO:048015	10.3	TYMS, PCNA, MTOR, FOXO1, MDM2, IGF1R
6	ovarian follicle development	GO:001541	10.3	BCL2L1, ICAM1, BAX, AHR, BCL2, KDR
7	male gonad development	GO:008584	10.3	BCL2, WT1, ERCC1, BCL2L1, KIT, KITLG
8	negative regulation of transcription, DNA-dependent	GO:045892	10.2	GCLC, BIRC5, RARA, BMP4, BMP2, VDR
9	cell proliferation	GO:008283	10.2	EGFR, BLZF1, HRAS, BCL2L1, S100B, IL2RA
10	G1 phase of mitotic cell cycle	GO:000080	10.2	CDK6, CDKN1A, CDKN2B, CDKN2A, CDKN1C, CDK4
11	virus-host interaction	GO:019048	10.2	SMARCB1, TNFRSF1A, TP53, CASP8, MDM2, BAX
12	positive regulation of fibroblast proliferation	GO:048146	10.1	PDGFRA, CDKN1A, CDK4, MIF, EREG, EGFR
13	positive regulation of gene expression	GO:010628	10.1	VDR, VEGFA, CSF2, KIT, CD44, CSF1
14	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	MTOR, RAF1, KRAS, PTEN, MDM2, FGFR4
15	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.0	HRAS, FLT4, MIF, FGF2, PRKCZ, PDGFRA
16	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.0	BAX, MYC, CDKN2A, IFI27, CASP8, TNF
17	activation of pro-apoptotic gene products	GO:008633	10.0	BAX, IFI27, CASP8, TNFRSF10B, TNFSF10, MYC
18	positive regulation of MAP kinase activity	GO:043406	10.0	CD40, ERBB2, EGFR, TNF, KRAS, EGF
19	positive regulation of epithelial cell proliferation	GO:050679	9.9	NME1, EGFR, ERBB2, HRAS, BMP4, TGFB1
20	response to DNA damage stimulus	GO:006974	9.9	CASP9, MYC, WRN, TOP2A, CTLA4, TP53
21	Ras protein signal transduction	GO:007265	9.8	KRAS, NRAS, CCNA2, TP53, RASSF1, CDKN1A
22	anti-apoptosis	GO:006916	9.8	IL10, NFKB1, GCLC, TNF, PRKCZ, IGF1R
23	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.8	IL3, MIF, CD44, MTOR, VEGFA, SEMA4D
24	positive regulation of cell migration	GO:030335	9.8	VEGFA, ABCC1, EGFR, PDGFRA, BMP2, KDR
25	response to hypoxia	GO:001666	9.7	PML, CXCR4, TNF, XRCC1, MMP9, MB
26	positive regulation of apoptotic process	GO:043065	9.7	BMP4, PTGS2, STK3, TOP2A, CTNNB1, BMP2
27	induction of apoptosis by extracellular signals	GO:008624	9.7	TNFRSF1A, TNFRSF10B, PRKCA, VDR, BAX, TNFSF10
28	cell cycle arrest	GO:007050	9.6	CDKN2A, GADD45A, PML, TGFB1, TSG101, TP53
29	protein autophosphorylation	GO:046777	9.6	IGF1R, PDGFRA, ERBB2, STK4, ALK, MAPK14
30	epidermal growth factor receptor signaling pathway	GO:007173	9.5	RAF1, PRKCA, CASP9, TGFB1, EGFR, EGF
31	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.5	MIF, TGFB1, IL6, VEGFA, RAF1, BCL2
32	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.5	NFKB1, WT1, AHR, TGFB1, MDM2, TNF
33	positive regulation of protein phosphorylation	GO:001934	9.4	IGF2, CD40, FLT4, SEMA4D, VEGFA, BMP2
34	positive regulation of endothelial cell proliferation	GO:001938	9.3	PRKCA, BMP2, VEGFA, FGF2, BMP4, KDR
35	angiogenesis	GO:001525	9.2	EREG, PTEN, EGF, TYMP, PRKCA, CSPG4
36	blood coagulation	GO:007596	9.1	VEGFC, VEGFA, SERPINE1, SERPINA1, RAF1, EGF
37	induction of apoptosis by intracellular signals	GO:008629	9.1	TP53, HRAS, CASP9, CASP8, CDKN1A, BAX
38	response to organic cyclic compound	GO:014070	9.0	MSH2, SERPINA1, BMP4, CDKN1A, MET, IL1RN
39	positive regulation of transcription, DNA-dependent	GO:045893	8.8	NFKB1, TP53, CCNA2, MDK, IL6, IL10
40	negative regulation of apoptotic process	GO:043066	8.7	IL6, IL1RN, GSTP1, ING2, MIF, FLT4
41	inflammatory response	GO:006954	8.7	TNF, TNFRSF1A, PTGS2, BMP2, AIMP1, IL6
42	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.6	KIT, IL6, SMARCB1, PTEN, TNF, ESR2
43	apoptotic process	GO:006915	8.5	GADD45A, CXCR4, PRKCA, PRAME, STK3, STK4
44	response to estradiol stimulus	GO:032355	8.5	SERPINA1, PRKCA, TGFB1, AHR, CTNNB1, PTGS2
45	platelet activation	GO:030168	8.5	MAPK14, PRKCA, PRKCZ, TGFB1, SERPINE1, IL6
46	positive regulation of cell proliferation	GO:008284	8.4	KIT, IL2, IL3, IL6, MDM2, IGF1R
47	response to drug	GO:042493	8.2	MET, MGMT, MMP9, CDH1, CDK4, CDKN1A
48	negative regulation of cell proliferation	GO:008285	7.8	TP53, PRKCA, PML, NME1, STK4, TFAP2A
49	signal transduction	GO:007165	7.5	ING2, KIT, IGF1R, ALK, HRAS, ESR1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	FGF2, ESR1, HRAS, IFNG, MAPK14, IL6

Molecular functions related to soft tissue sarcoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	ubiquitin protein ligase binding	GO:031625	10.6	SLC22A18, PML, CXCR4, TSG101, TP53, CD40
2	protease binding	GO:002020	10.1	SERPINA1, BCL2, KIT, FAP, TP53, SERPINE1
3	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.5	PDGFRA, EGFR, FLT4, NTRK3, ERBB2, ALK
4	protein homodimerization activity	GO:042803	9.5	VEGFA, ERCC5, HLA-G, TERT, PTGS2, TOP2A
5	protein heterodimerization activity	GO:046982	9.2	MET, IL12A, ERBB2, TP53, EGFR, AHR
6	identical protein binding	GO:042802	9.1	EGFR, BAX, BCL2L1, BCL2, BIRC5, RASSF1
7	cytokine activity	GO:005125	8.8	CSF3, CSF2, IL10, FGF2, MIF, CD40LG
8	ATP binding	GO:005524	8.7	TRIO, ERBB2, ALK, IGF1R, MAPK10, TOP2A
9	growth factor activity	GO:008083	8.7	CSF3, IL10, FGF2, LEP, BMP4, BMP2
10	enzyme binding	GO:019899	8.1	PTEN, CD40, MSH2, BIRC5, BLZF1, RARA
11	protein binding	GO:005515	5.1	EGF, CTLA4, CYCS, PTEN, TERT, TNFSF10