MCID: SLT008
MIFTS: 55

Solitary Fibrous Tumor malady

Cancer diseases, Rare diseases categories

Summaries for Solitary Fibrous Tumor

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Solitary fibrous tumor (SFT) is a rare mesenchymal tumor originating in the pleura or at virtually any... more...

MalaCards: Solitary Fibrous Tumor is related to hemangiopericytoma and fibrous meningioma. An important gene associated with Solitary Fibrous Tumor is NAB2 (NGFI-A binding protein 2 (EGR1 binding protein 2)), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The compounds 2-methoxyethanol and orcein have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and thyroid, and related mouse phenotypes are muscle and cellular.

Description from OMIM:48 234820

Aliases & Classifications for Solitary Fibrous Tumor

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Sources:
50Orphanet, 48OMIM, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 50 
Rare tumors


Characteristics (Orphanet epidemiological data):

50
solitary fibrous tumor:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

solitary fibrous tumor 50 48 63


External Ids:

OMIM48 234820
MESH via Orphanet37 D006393
ICD10 via Orphanet27 C49.9
SNOMED-CT via Orphanet60 134335004, 36060005
UMLS via Orphanet64 C0018922

Related Diseases for Solitary Fibrous Tumor

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Solitary Fibrous Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1hemangiopericytoma31.2DES, IGF2, MUC1, ACTC1, S100B
2fibrous meningioma30.6S100B, MUC1
3adenoma30.6ACTC1, NES, MUC1, IGF2
4meningioma30.6IGF2, MUC1, PDGFRB, S100B
5fasciitis30.4ACTC1
6astrocytoma30.4S100B, PDGFRB, NES
7hemangioma30.4ACTC1
8sarcoma30.4DES, IGF2, MUC1, NES, ACTC1, PDGFRB
9adenocarcinoma30.3MUC1, NES, ACTC1, PDGFRB
10desmoid tumor30.3PDGFRB, ACTC1, DES
11desmoplastic small round cell tumor30.3DES, MUC1
12synovial sarcoma30.3DES, IGF2, MUC1, NES, S100B
13malignant peripheral nerve sheath tumor30.3S100B, NES
14angiosarcoma30.3MUC1, ACTC1
15fibrous histiocytoma30.3S100B, ACTC1, DES
16pilocytic astrocytoma30.2S100B, PDGFRB, NES
17leiomyoma30.1DES, IGF2, NES, ACTC1, S100B
18neurofibroma30.1MUC1, ACTC1, PDGFRB, S100B
19gastrointestinal stromal tumor30.1S100B, PDGFRB, ACTC1, NES, DES
20pleomorphic adenoma30.1DES, IGF2, MUC1, ACTC1, S100B
21dermatofibrosarcoma protuberans30.1DES, MUC1, ACTC1, PDGFRB, S100B
22rhabdomyosarcoma30.1DES, IGF2, NES, ACTC1, PDGFRB, S100B
23hypoglycemia10.9
24meningitis10.7
25thyroiditis10.7
26prostatitis10.6
27cervicitis10.5
28hypoglycemic coma10.4
29malignant peritoneal solitary fibrous tumor10.4
30malignant pleural solitary fibrous tumor10.4
31meninges hemangiopericytoma10.4
32islet cell tumor10.4
33pancreatitis10.4
34pituitary adenoma10.4
35sinusitis10.4
36spindle cell lipoma10.3
37goiter10.3
38hepatitis10.3
39lipoma10.3
40fasting hypoglycemia10.3
41cardiac tamponade10.2
42benign fibrous mesothelioma10.2
43obstructive sleep apnea10.2
44fibrillary astrocytoma10.2
45exophthalmos10.2
46secondary hypertrophic osteoarthropathy10.2
47choledochal cyst10.2
48tonsillitis10.2
49hypokalemia10.2
50obstructive jaundice10.2

Graphical network of the top 20 diseases related to Solitary Fibrous Tumor:



Diseases related to solitary fibrous tumor

Symptoms for Solitary Fibrous Tumor

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

234820

Clinical features from OMIM:

234820

Drugs & Therapeutics for Solitary Fibrous Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Solitary Fibrous Tumor

Drug clinical trials:

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Search NIH Clinical Center for Solitary Fibrous Tumor

Search CenterWatch for Solitary Fibrous Tumor

Genetic Tests for Solitary Fibrous Tumor

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Anatomical Context for Solitary Fibrous Tumor

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34MalaCards
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MalaCards organs/tissues related to Solitary Fibrous Tumor:

34
Kidney, Liver, Thyroid, Spinal cord, Lung, Pancreas, Prostate, Breast, Uterus, Pituitary, Adrenal gland, Pineal, Cervix, Adipocyte, Thymus, Bone, Tongue, Tonsil, Skin, Salivary gland, Trachea, Endothelial, Heart, Cerebellum

Animal Models for Solitary Fibrous Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Solitary Fibrous Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7PDGFRB, ACTC1, IGF2, DES
2MP:00053848.1IGF2, NAB2, NES, STAT6, ACTC1, PDGFRB
3MP:00053868.0DES, IGF2, NAB2, NES, S100B
4MP:00053918.0IGF2, MUC1, STAT6, PDGFRB
5MP:00053788.0IGF2, NAB2, NES, STAT6, ACTC1, PDGFRB
6MP:00028737.9NAB2, MUC1, ACTC1, PDGFRB, S100B
7MP:00107687.7DES, IGF2, NAB2, NES, STAT6, ACTC1
8MP:00107717.6S100B, PDGFRB, STAT6, MUC1, NAB2, IGF2
9MP:00053767.5DES, IGF2, MUC1, STAT6, ACTC1, PDGFRB

Publications for Solitary Fibrous Tumor

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53PubMed
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Articles related to Solitary Fibrous Tumor:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
2
Correlation between clinical features, imaging and pathologic findings in recurrent solitary fibrous tumor of the orbit. (23909414)
2013
3
68Ga DOTATATE PET/CT Imaging of a Solitary Fibrous Tumor of the Nasopharynx. (24152636)
2013
4
Spinal extradural solitary fibrous tumor with retiform and papillary features. (23632234)
2013
5
Solitary fibrous tumor of the accessory parotid gland: a unique case. (23834136)
2013
6
An uncommon location of solitary fibrous tumor. (23562227)
2013
7
Radiology-Pathology Conference: 18F FDG PET-CT imaging of solitary fibrous tumor of the pleura. (23116726)
2013
8
Hepatic solitary fibrous tumor: report of a rare case. (22771653)
2012
9
Huge malignant solitary fibrous tumor of the pleura. (22566249)
2012
10
Paratesticular solitary fibrous tumor: a rare cause of a hypervascular extratesticular mass. (21266569)
2011
11
Delayed liver metastasis of a meningeal solitary fibrous tumor. (22319969)
2011
12
Primary anaplastic solitary fibrous tumor of the tentorium cerebelli. (21696961)
2011
13
Hemangiopericytoma/Solitary fibrous tumor of the oral cavity. (21378362)
2011
14
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
15
Imaging of benign solitary fibrous tumor of the pleura: a pictorial essay. (21139938)
2010
16
Neurofibroma of kidney: an uncommon neoplasm and diagnostic dilemma with solitary fibrous tumor. (21119287)
2010
17
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (20559119)
2010
18
Giant solitary fibrous tumor of the pleura: an analysis of five patients. (20628740)
2010
19
Intra- and extracranial solitary fibrous tumor of the trigeminal nerve: CT and MR imaging appearance. (19762459)
2010
20
Lines of cell differentiation in solitary fibrous tumor: an ultrastructural and immunohistochemical study of 10 cases. (19929175)
2009
21
Solitary fibrous tumor of the pleura: surgery and clinical course in 18 cases. (19713334)
2009
22
A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. (19673425)
2009
23
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. (19319642)
2009
24
Solitary fibrous tumor with giant multinucleated cells in the retroperitoneum - a case report. (22666708)
2009
25
Solitary fibrous tumor of the abdominal wall. (19967496)
2009
26
A malignant solitary fibrous tumor in the retroperitoneum. (18463965)
2008
27
Solitary fibrous tumor in the cervical spine with destructive vertebral involvement: a case report and review of the literature. (18060553)
2008
28
Orbital giant cell angiofibroma recurring as a solitary fibrous tumor. (18645449)
2008
29
Solitary fibrous tumor of the thigh with epithelioid features: a case report. (17577399)
2007
30
Hypoglycemia in a patient with a huge malignant solitary fibrous tumor of the pleura. (17988280)
2007
31
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor. (17455098)
2007
32
Vaginal solitary fibrous tumor: a case report with recurrence after incomplete excision. (17194953)
2007
33
Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia. (18040628)
2007
34
Solitary fibrous tumor of the lateral ventricle: CT appearances and pathologic correlation with follow-up. (17110682)
2006
35
Solitary fibrous tumor of the pelvis. (16099582)
2006
36
D2-40 staining in sinonasal-type hemangiopericytoma--further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor. (16362413)
2006
37
Extrathoracic solitary fibrous tumor of the pelvic peritoneum with central malignant degeneration on CT and MRI. (16215968)
2005
38
Intrapulmonary solitary fibrous tumor in an eight-year-old male. (15957162)
2005
39
Right atrial solitary fibrous tumor - a new cardiac neoplasm? (17670440)
2005
40
Solitary fibrous tumor of the orbit--two cases and a review of the literature. (15316820)
2005
41
Solitary fibrous tumor of the orbit. (15617311)
2004
42
Solitary fibrous tumor of the pericardium presenting itself as a pericardial effusion and right ventricular obstruction. (15365524)
2004
43
Solitary fibrous tumor of the tentorium cerebelli. Case report. (15550899)
2004
44
Nasal solitary fibrous tumor arising from the anterior cranial fossa. (16145606)
2004
45
Solitary fibrous tumor of the spinal cord: case report and review of the literature. (15314822)
2004
46
Solitary fibrous tumor of the pleura: a review. (17472272)
2003
47
Solitary fibrous tumor of the oral mucosa--morphological and immunohistochemical profile in the differential diagnosis with hemangiopericytoma. (12676265)
2003
48
Expression and localization of basic fibroblast growth factor and its mRNA in solitary fibrous tumor. (11598621)
2001
49
Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia. (11372615)
2001
50
Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II. (9589464)
1998

Variations for Solitary Fibrous Tumor

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Expression for genes affiliated with Solitary Fibrous Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Solitary Fibrous Tumor

Search GEO for disease gene expression data for Solitary Fibrous Tumor.

Pathways for genes affiliated with Solitary Fibrous Tumor

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN
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Pathways related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ACTC1, DES
29.6ACTC1, IGF2
39.6STAT6, PDGFRB
4
Show member pathways
7.9PDGFRB, STAT6, MUC1, IGF2, DES

Compounds for genes affiliated with Solitary Fibrous Tumor

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol469.9ACTC1, IGF2
2orcein469.5S100B, ACTC1, DES
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.4S100B, DES
44-hydroxytamoxifen469.4S100B, STAT6, IGF2
5acetone469.4MUC1, IGF2
6ganglioside469.4DES, NES, PDGFRB
7eosin469.4S100B, MUC1
8biotin46 25 1211.2DES, MUC1, ACTC1
9progestin469.1DES, IGF2, MUC1
10dihydrotestosterone46 30 25 1212.1DES, IGF2, MUC1
11methionine469.1DES, PDGFRB, S100B
12norepinephrine46 25 1211.0S100B, IGF2, DES
13paclitaxel46 52 1210.9IGF2, PDGFRB, S100B
145fluorouracil468.9IGF2, MUC1, PDGFRB
15agar468.9PDGFRB, MUC1, IGF2
16acth468.8S100B, MUC1, IGF2
17acetylcholine46 52 30 25 1212.8DES, NES, S100B
18bromodeoxyuridine468.8S100B, PDGFRB, NES, DES
19actinomycin d468.8DES, IGF2, MUC1, STAT6
20chloramphenicol46 3 52 1211.8IGF2, MUC1, S100B
21ethanol46 52 25 1211.7S100B, MUC1, DES
22s 100468.7DES, MUC1, ACTC1, S100B
23reticulin468.7DES, MUC1, ACTC1, S100B
24wortmannin468.7S100B, PDGFRB, STAT6
25mucicarmine468.7S100B, ACTC1, MUC1, DES
26b 723468.7DES, MUC1, ACTC1, S100B
27ribonucleic acid468.7PDGFRB, ACTC1, MUC1, IGF2
28hematoxylin468.7DES, MUC1, ACTC1, S100B
29steroid468.7DES, IGF2, STAT6, ACTC1, S100B
30formaldehyde46 259.6DES, MUC1, ACTC1, S100B
31matrigel468.6PDGFRB, ACTC1, NES, MUC1
32imatinib46 52 1210.5DES, IGF2, ACTC1, PDGFRB, S100B
33thymidine46 259.5S100B, MUC1, IGF2, DES
34nitric oxide46 25 1210.3S100B, NES, MUC1, DES
35dexamethasone46 52 30 1211.2IGF2, MUC1, STAT6, ACTC1, S100B
36glycogen46 259.2DES, IGF2, MUC1, ACTC1, S100B
37creatinine468.2DES, IGF2, MUC1, ACTC1, S100B
38threonine468.1DES, MUC1, STAT6, PDGFRB, S100B
39cysteine468.0S100B, PDGFRB, MUC1, IGF2, DES
40testosterone46 62 25 1210.7DES, IGF2, MUC1, ACTC1, PDGFRB, S100B
41calcium46 52 25 1210.7DES, MUC1, STAT6, ACTC1, PDGFRB, S100B
42serine467.7DES, IGF2, MUC1, STAT6, PDGFRB, S100B
43oxygen46 258.6DES, MUC1, NES, ACTC1, PDGFRB, S100B
44paraffin467.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
45progesterone46 30 62 25 1211.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
46estrogen467.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
47glucose467.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
48vegf466.9S100B, DES, IGF2, NAB2, MUC1, NES
49retinoic acid46 257.8DES, IGF2, MUC1, NES, STAT6, ACTC1
50tyrosine466.8DES, IGF2, MUC1, NES, STAT6, ACTC1

GO Terms for genes affiliated with Solitary Fibrous Tumor

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17Gene Ontology
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Cellular components related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3S100B, PDGFRB, ACTC1, STAT6, NES, MUC1

Biological processes related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:0550039.6PDGFRB, ACTC1
2muscle filament slidingGO:0300499.6DES, ACTC1
3positive regulation of mitosisGO:0458409.5PDGFRB, IGF2
4memoryGO:0076139.1S100B, IGF2
5positive regulation of cell proliferationGO:0082848.9S100B, PDGFRB, IGF2

Products for genes affiliated with Solitary Fibrous Tumor

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Sources for Solitary Fibrous Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet