MCID: SLT008
MIFTS: 55

Solitary Fibrous Tumor malady

Cancer category

Summaries for Solitary Fibrous Tumor

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Solitary fibrous tumor (SFT) is a rare mesenchymal tumor originating in the pleura or at virtually any... more...

MalaCards: Solitary Fibrous Tumor is related to fibrous meningioma and adenoma. An important gene associated with Solitary Fibrous Tumor is STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced), and among its related pathways are TGF-Beta Pathway and Osteoblast Signaling. The compounds estrogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are vision/eye and skeleton.

Description from OMIM:47 234820

Aliases & Classifications for Solitary Fibrous Tumor

Sources:
49Orphanet, 47OMIM, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
solitary fibrous tumor:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

solitary fibrous tumor 49 47 61


External Ids:

OMIM47 234820
MESH via Orphanet36 D006393
ICD10 via Orphanet26 C49.9
SNOMED-CT via Orphanet58 134335004, 36060005
UMLS via Orphanet62 C0018922

Related Diseases for Solitary Fibrous Tumor

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Solitary Fibrous Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous meningioma30.7MUC1, S100B
2adenoma30.6ACTC1, MUC1, IGF2, NES, S100A1, CALB2
3synovial sarcoma30.4KIT, MUC1, IGF2, DES, NES, S100B
4astrocytoma30.4KDR, GFAP, NES, PDGFRA, PDGFRB, S100B
5adenocarcinoma30.4ACTC1, KDR, CD34, MUC1, F13A1, NES
6hemangioendothelioma30.2CD34
7desmoplastic small round cell tumor30.2MUC1, DES
8gastrointestinal stromal tumor30.2KIT, PDGFRA
9dedifferentiated liposarcoma30.2KIT, DES
10papillary carcinoma30.2ACTC1, MUC1, S100A1, CALB2
11pilocytic astrocytoma30.2GFAP, NES, PDGFRB, S100B
12anaplastic astrocytoma30.2GFAP, NES, PDGFRA, PDGFRB
13desmoid tumor30.2ACTC1, KIT, DES, PDGFRA, PDGFRB
14fibrous histiocytoma30.2ACTC1, CD34, DES, F13A1, S100B, VIM
15pleomorphic adenoma30.2ACTC1, GFAP, MUC1, IGF2, DES, S100A1
16angiosarcoma30.2ACTC1, KDR, CD34, MUC1, PDPN, PDGFRA
17dermatofibrosarcoma protuberans30.2ACTC1, KIT, CD34, MUC1, DES, F13A1
18hypoglycemia10.9
19malignant pleural solitary fibrous tumor10.5
20potter's syndrome10.5
21hypoglycemic coma10.4
22malignant peritoneal solitary fibrous tumor10.4
23spindle cell lipoma10.4
24breast myofibroblastoma10.3
25fibrous synovial sarcoma10.3
26meninges hemangiopericytoma10.3
27fasting hypoglycemia10.3
28substernal goiter10.2
29cardiac tamponade10.2
30breast hemangiopericytoma10.2
31acute pancreatitis10.2
32benign fibrous mesothelioma10.2
33kidney hemangiopericytoma10.2
34obstructive jaundice10.2
35dermatofibrosarcoma10.2
36mediastinum liposarcoma10.2
37exophthalmos10.2
38fibrillary astrocytoma10.2
39conventional malignant hemangiopericytoma10.2
40secondary hypertrophic osteoarthropathy10.2
41choledochal cyst10.2
42hypokalemia10.2
43small cell sarcoma10.2
44kidney lipoma10.2
45breast lipoma10.2
46adenofibroma10.2
47bladder carcinoma10.2
48heart tumor10.2
49superior vena cava syndrome10.2
50dysphagia10.2

Graphical network of the top 20 diseases related to Solitary Fibrous Tumor:



Diseases related to solitary fibrous tumor

Clinical Features for Solitary Fibrous Tumor

Sources:
47OMIM
See all sources

Clinical features from OMIM:

234820

Clinical synopsis from OMIM:

234820

Drugs & Therapeutics for Solitary Fibrous Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Solitary Fibrous Tumor

Drug clinical trials:

Search ClinicalTrials for Solitary Fibrous Tumor

Search NIH Clinical Center for Solitary Fibrous Tumor

Search CenterWatch for Solitary Fibrous Tumor

Genetic Tests for Solitary Fibrous Tumor

Anatomical Context for Solitary Fibrous Tumor

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Solitary Fibrous Tumor:

33
Skin, Liver, Tongue, Spinal cord, Kidney, Lung, Uterus, Thymus, Cerebellum, Heart, Small intestine, Adipocyte, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Prostate, Cervix, Tonsil, T cells, Endothelial, Trachea, Pancreatic islet, Pineal, Pituitary

Animal Models for Solitary Fibrous Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Solitary Fibrous Tumor

Sources:
51PubMed
See all sources

Articles related to Solitary Fibrous Tumor:

(show top 50)    (show all 569)
idTitleAuthorsYear
1
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
2
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (23313952)
2013
3
Malignant solitary fibrous tumor of the left ventricular epicardium. (23522212)
2013
4
Atypical solitary fibrous tumor of the nose and maxillary sinus. (22025279)
2013
5
Myxoid solitary fibrous tumor of the central nervous system. (24421842)
2013
6
Case 198: solitary fibrous tumor of the liver. (24062563)
2013
7
Refractory hypoglycemia controlled by sorafenib in solitary fibrous tumor. (23341512)
2013
8
Exceptionally large solitary fibrous tumor arising from the cheek: an immunohistochemical and ultrastructural study with a review of the literature. (24221815)
2013
9
Huge malignant solitary fibrous tumor of the pleura. (22566249)
2012
10
Parotid gland solitary fibrous tumor: a case report and clinicopathologic review of 22 cases from the literature. (22002440)
2012
11
An unusual slow-growing malignant orbital solitary fibrous tumor. (22385613)
2012
12
Epithelioid solitary fibrous tumor of the central nervous system. (21908099)
2012
13
Pedunculated solitary fibrous tumor of the pleura manifesting as a migrating chest mass: report of a case. (22167481)
2012
14
Solitary fibrous tumor of the vagina: a case report with review of the literature. (21742644)
2012
15
Primary anaplastic solitary fibrous tumor of the tentorium cerebelli. (21696961)
2011
16
The central nervous system solitary fibrous tumor: a review of clinical, imaging and pathologic findings among all reported cases from 1996 to 2010. (21872387)
2011
17
Solitary fibrous tumor of the petrous bone: a successful treatment option. (21905794)
2011
18
Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report. (21714864)
2011
19
Solitary fibrous tumor of the adrenal gland with unusual immunophenotype: a potential diagnostic problem and a brief review of endocrine organ solitary fibrous tumor. (20191330)
2010
20
Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura. (20972860)
2010
21
Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: a comparison. (20165866)
2010
22
Solitary fibrous tumor arising in an intrathoracic goiter. (20373988)
2010
23
Giant cell angiofibroma, a variant of solitary fibrous tumor, of the orbit in a 16-year-old girl. (19966660)
2009
24
Atypical presentation of a case of solitary fibrous tumor of the orbit. (19839906)
2009
25
Solitary fibrous tumor in the maxillary sinus treated by endoscopic medial maxillectomy. (18328654)
2009
26
Solitary fibrous tumor of the liver expressing CD34 and vimentin: a case report. (18985821)
2008
27
Myxoid solitary fibrous tumor of the retroperitoneum: MRI findings with the pathologic correlation. (18525232)
2008
28
Solitary fibrous tumor of the pleura presenting with syncope episodes when coughing. (18713458)
2008
29
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia. (18552458)
2008
30
Solitary fibrous tumor of the thigh with epithelioid features: a case report. (17577399)
2007
31
Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy. (17316417)
2007
32
Recurrent intracranial solitary fibrous tumor initially diagnosed as hemangiopericytoma. (18095142)
2007
33
Chromosomal aberrations in oral solitary fibrous tumor. (17452261)
2007
34
Solitary fibrous tumor of the pleura: apparent diffusion coefficient (ADC) value and ADC map to predict malignant transformation. (17659560)
2007
35
Imaging findings of solitary fibrous tumor of the prostate: a case report. (16735192)
2006
36
Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. (17203593)
2006
37
Renal hilar mass in an 85-year-old woman. Solitary fibrous tumor. (16390227)
2006
38
Solitary fibrous tumor of the retropharynx causing obstructive sleep apnea. (16798403)
2006
39
Right atrial solitary fibrous tumor - a new cardiac neoplasm? (17670440)
2005
40
Hypoglycemic coma revealing a solitary fibrous tumor of the pleura]. (16292188)
2005
41
Inverted solitary fibrous tumor of the pleura mimicking a pulmonary mass. (16440575)
2005
42
Meningeal solitary fibrous tumor: report of a case and literature review. (16245214)
2005
43
A case of malignant solitary fibrous tumor of the prostate. (16287498)
2005
44
Solitary fibrous tumor of the uterus producing high-molecular-weight insulin-like growth factor II and associated with hypoglycemia. (15626921)
2005
45
Familial solitary fibrous tumor of the pleura: a case report. (15888869)
2005
46
Epithelioid solitary fibrous tumor in the ischioanal fossa. (15891904)
2005
47
Extrapleural benign solitary fibrous tumor in the shoulder of a 9-year-old girl: case report and review of the literature. (15630539)
2004
48
Solitary fibrous tumor of the pleura: a review. (17472272)
2003
49
Large solitary fibrous tumor of the kidney: report of two cases and review of the literature. (11688580)
2001
50
Malignant solitary fibrous tumor of the pleura causing recurrent hypoglycemia; immunohistochemical stain of insulin-like growth factor i receptor in three cases. (11306751)
2001

Genetic Variations for Solitary Fibrous Tumor

Expression for genes affiliated with Solitary Fibrous Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Solitary Fibrous Tumor

Search GEO for disease gene expression data for Solitary Fibrous Tumor.

Pathways for genes affiliated with Solitary Fibrous Tumor

Sources:
52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 50PharmGKB, 60Tocris Bioscience
See all sources

Pathways related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2STAT6, IGF2
210.2PDGFRA, PDGFRB
3
Hide members
10.2PDGFRA, PDGFRB
4
Hide members
10.1ACTC1, DES, VIM
5
Hide members
10.1PDGFRA, STAT6, IGF2
610.0PDGFRB, STAT6, KDR
710.0IGF2, PDGFRA, PDGFRB
810.0KDR, PDGFRA, PDGFRB
910.0PDGFRB, PDGFRA, KDR
10
Hide members
9.9GFAP, DES, NES, VIM
119.9VIM, PDPN, DES, ACTC1
12
Hide members
9.9PDGFRB, PDGFRA, IGF2, KDR
13
Hide members
9.8PDGFRB, PDGFRA, KIT, KDR
14
Hide members
9.8PDGFRB, PDGFRA, KIT, KDR
159.8PDGFRB, PDGFRA, KIT, KDR
169.7ACTC1, KDR, KIT, IGF2, PDGFRA
17
Hide members
9.7S100B, PDGFRB, PDGFRA, KIT, GFAP
18
Hide members
9.7PDGFRB, PDGFRA, IGF2, KIT, KDR
19
Hide members
9.7PDGFRB, PDGFRA, IGF2, KIT, KDR
20
Hide members
9.6PDGFRB, PDGFRA, STAT6, IGF2, KIT, KDR
21
Hide members
9.6VIM, PDGFRB, PDGFRA, IGF2, KIT, KDR
22
Hide members
9.3VIM, PDGFRB, PDGFRA, STAT6, DES, IGF2
23
Hide members
9.3S100B, PDGFRB, PDGFRA, STAT6, IGF2, KIT

Compounds for genes affiliated with Solitary Fibrous Tumor

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1estrogen4510.4GFAP, F13A1, CALB2
2orcein4510.4VIM, S100B, DES, ACTC1
3glycogen45 2411.3IGF2, KIT, GFAP, ACTC1
4eosin4510.3VIM, S100B, MUC1, GFAP
5creatinine4510.3ACTC1, GFAP, IGF2
62-methoxyethanol4510.3VIM, S100A1, IGF2, ACTC1
7su66684510.2KDR, KIT, PDGFRB
8toluidine4510.2KIT, DES, S100A1, VIM
9reticulin4510.2ACTC1, GFAP, MUC1, DES, VIM
10pkc 4124510.2PDGFRB, PDGFRA, KIT, KDR
11Pazopanib1110.2PDGFRB, PDGFRA, KIT, KDR
12streptozotocin4510.2GFAP, NES
13Regorafenib1110.2KDR, KIT, PDGFRA, PDGFRB
14sunitinib45 50 1112.2KDR, KIT, PDGFRA, PDGFRB
15acetylcholine45 50 29 11 2414.1GFAP, NES, S100A1, CALB2
16ganglioside4510.1VIM, PDGFRB, NES, DES, GFAP
17glucose4510.1PDGFRB, IGF2, MUC1, GFAP, ACTC1
18zd64744510.1KDR, KIT, PDGFRB
19gefitinib45 50 1112.1VIM, PDGFRB, IGF2, KIT, KDR
20serine4510.1S100B, STAT6, DES, GFAP
21progestin4510.1VIM, DES, IGF2, MUC1, KDR
22dexamethasone45 50 29 1113.0S100B, STAT6, IGF2, GFAP, KDR
23bromodeoxyuridine4510.0VIM, S100B, PDGFRB, NES, DES, GFAP
24biotin45 11 2412.0VIM, S100A1, DES, MUC1, ACTC1
25paclitaxel45 50 1111.9CALB2, S100B, PDGFRB, IGF2, GFAP, KDR
26s 100459.9ACTC1, GFAP, MUC1, DES, F13A1, S100B
27formaldehyde45 2410.9VIM, S100B, DES, MUC1, KIT, GFAP
28mucicarmine459.9DES, S100A1, S100B, CALB2, VIM, MUC1
29silver459.8CALB2, S100A1, F13A1, DES, CD34, GFAP
30matrigel459.8VIM, PDGFRB, NES, MUC1, GFAP, KDR
31agar459.8VIM, PDGFRB, IGF2, MUC1, CD34, GFAP
32methionine459.8VIM, S100B, PDGFRB, DES, KIT, GFAP
33imatinib45 50 1111.8S100B, PDGFRB, PDGFRA, DES, IGF2, KIT
34tgf beta1459.7VIM, PDGFRB, PDGFRA, IGF2, KDR
35iron45 2410.7VIM, S100B, S100A1, F13A1, DES, GFAP
36lactate459.7VIM, S100B, DES, IGF2, KIT, GFAP
37b 723459.5ACTC1, MUC1, DES, F13A1, PDPN, S100A1
38rapamycin459.5VIM, PDGFRB, PDGFRA, IGF2, KIT, KDR
39testosterone45 60 11 2412.4VIM, CALB2, S100B, PDGFRB, DES, IGF2
40choline45 11 2411.4VIM, CALB2, S100B, NES, GFAP
41nitric oxide45 11 2411.4CALB2, S100B, S100A1, NES, DES, MUC1
42cysteine459.4VIM, S100B, S100A1, PDGFRB, DES, IGF2
43thymidine45 2410.3CALB2, S100B, PDGFRA, DES, IGF2, MUC1
44hematoxylin459.0GFAP, KIT, CD34, MUC1, DES, F13A1
45calcium45 50 11 2412.0PDGFRA, PDGFRB, S100A1, S100B, CALB2, STAT6
46progesterone45 60 29 11 2412.8GFAP, VIM, KIT, CD34, MUC1, IGF2
47retinoic acid45 249.7CD34, MUC1, IGF2, DES, NES, STAT6
48tyrosine458.4STAT6, PDPN, PDGFRA, PDGFRB, S100A1, S100B
49vegf458.3ACTC1, KDR, GFAP, KIT, NAB2, CD34
50paraffin458.0ACTC1, S100A1, S100B, CALB2, VIM, PDGFRB

GO Terms for genes affiliated with Solitary Fibrous Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to plasma membraneGO:03122610.1PDGFRA, PDGFRB
2intermediate filamentGO:0058829.9VIM, NES, DES, GFAP
3apical plasma membraneGO:0163249.8CD34, MUC1, PDPN, PDGFRB
4external side of plasma membraneGO:0098979.5PDGFRA, CD34, KIT, KDR
5cytoplasmGO:0057378.5ACTC1, VIM, CALB2, S100B, PDGFRB, PDGFRA

Biological processes related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.5PDGFRB, PDGFRA
2Bergmann glial cell differentiationGO:06002010.5VIM, GFAP
3positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.4PDGFRB, PDGFRA
4cardiac myofibril assemblyGO:05500310.4ACTC1, PDGFRA, PDGFRB
5positive regulation of phospholipase C activityGO:01086310.4KIT, PDGFRA, PDGFRB
6endothelium developmentGO:00315810.4CD34, KDR
7cell chemotaxisGO:06032610.3PDGFRB, PDGFRA, KIT
8positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.3KIT, PDGFRA, PDGFRB
9muscle filament slidingGO:03004910.3ACTC1, DES, VIM
10stem cell proliferationGO:07208910.3NES, CD34
11retina vasculature development in camera-type eyeGO:06129810.3PDGFRB, PDGFRA
12signal transduction by phosphorylationGO:02301410.3KDR, KIT
13positive regulation of MAPK cascadeGO:04341010.2KDR, KIT, IGF2
14positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.2KDR, KIT, PDGFRA, PDGFRB
15peptidyl-tyrosine phosphorylationGO:01810810.2PDGFRB, PDGFRA, KIT, KDR
16astrocyte developmentGO:01400210.2VIM, GFAP
17positive regulation of vasculogenesisGO:200121410.2KDR, CD34
18response to hyperoxiaGO:05509310.1PDPN, PDGFRB
19regulation of cell shapeGO:00836010.1S100B, PDPN, KIT, KDR
20intermediate filament organizationGO:04510910.1GFAP, VIM
21positive regulation of cell migrationGO:03033510.1PDGFRB, PDGFRA, PDPN, KDR
22protein autophosphorylationGO:04677710.1PDGFRB, PDGFRA, KIT, KDR
23positive regulation of cell proliferationGO:0082849.9S100B, PDGFRB, PDGFRA, IGF2, KIT, KDR
24positive regulation of ERK1 and ERK2 cascadeGO:0703749.7KDR, PDGFRA, PDGFRB

Molecular functions related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.3KDR, PDGFRA
2S100 protein bindingGO:04454810.2S100A1, S100B
3vascular endothelial growth factor bindingGO:03808510.2KDR, PDGFRA, PDGFRB
4transmembrane receptor protein tyrosine kinase activityGO:00471410.1PDGFRA, KIT, KDR
5receptor signaling protein tyrosine kinase activityGO:00471610.1KDR, KIT
6platelet-derived growth factor bindingGO:04840710.1PDGFRB, PDGFRA
7structural constituent of cytoskeletonGO:00520010.1GFAP, DES, VIM
8identical protein bindingGO:0428029.9VIM, S100B, S100A1, STAT6, DES
9protein tyrosine kinase activityGO:0047139.7KDR, KIT, PDGFRB

Products for genes affiliated with Solitary Fibrous Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Solitary Fibrous Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet