MCID: SLT008
MIFTS: 55

Solitary Fibrous Tumor malady

Cancer diseases, Rare diseases categories
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Summaries for Solitary Fibrous Tumor

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Wikipedia:65 Solitary fibrous tumor (SFT) is a rare mesenchymal tumor originating in the pleura or at virtually any... more...

MalaCards based summary: Solitary Fibrous Tumor is related to fasciitis and hemangioma, and has symptoms including An important gene associated with Solitary Fibrous Tumor is NAB2 (NGFI-A binding protein 2 (EGR1 binding protein 2)), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The compounds 2-methoxyethanol and orcein have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and thyroid, and related mouse phenotypes are muscle and cellular.

Description from OMIM:46 234820

Aliases & Classifications for Solitary Fibrous Tumor

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Sources:
48Orphanet, 46OMIM, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Solitary Fibrous Tumor, Aliases & Descriptions:

Name: Solitary Fibrous Tumor 48 46 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
solitary fibrous tumor:
Age of onset: Variable; Age of death: Any age


External Ids:

OMIM46 234820
MESH via Orphanet35 D006393
ICD10 via Orphanet26 C49.9
UMLS via Orphanet63 C0018922

Related Diseases for Solitary Fibrous Tumor

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Diseases related to Solitary Fibrous Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1fasciitis31.0ACTC1
2hemangioma30.8ACTC1
3hemangiopericytoma30.8DES, IGF2, MUC1, ACTC1, S100B
4fibroma30.7ACTC1, DES
5fibrous meningioma30.7S100B, MUC1
6desmoid tumor30.5PDGFRB, ACTC1, DES
7desmoplastic small round cell tumor30.5DES, MUC1
8malignant peripheral nerve sheath tumor30.4S100B, NES
9angiosarcoma30.4MUC1, ACTC1
10fibrous histiocytoma30.4S100B, ACTC1, DES
11astrocytoma30.3S100B, PDGFRB, NES
12adenoma30.2ACTC1, NES, MUC1, IGF2
13pilocytic astrocytoma30.2S100B, PDGFRB, NES
14meningioma30.1IGF2, MUC1, PDGFRB, S100B
15adenocarcinoma30.1MUC1, NES, ACTC1, PDGFRB
16leiomyoma29.8DES, IGF2, NES, ACTC1, S100B
17neurofibroma29.8MUC1, ACTC1, PDGFRB, S100B
18gastrointestinal stromal tumor29.7S100B, PDGFRB, ACTC1, NES, DES
19synovial sarcoma29.7DES, IGF2, MUC1, NES, S100B
20pleomorphic adenoma29.6DES, IGF2, MUC1, ACTC1, S100B
21dermatofibrosarcoma protuberans29.6DES, MUC1, ACTC1, PDGFRB, S100B
22rhabdomyosarcoma29.4DES, IGF2, NES, ACTC1, PDGFRB, S100B
23sarcoma29.4DES, IGF2, MUC1, NES, ACTC1, PDGFRB
24hypoglycemia10.9
25meningitis10.9
26thyroiditis10.7
27prostatitis10.6
28cervicitis10.5
29infantile myofibromatosis10.5DES
30islet cell tumor10.4
31sinusitis10.4
32hypoglycemic coma10.4
33spindle cell lipoma10.4
34malignant peritoneal solitary fibrous tumor10.4
35malignant pleural solitary fibrous tumor10.4
36meninges hemangiopericytoma10.4
37goiter10.4
38lipoma10.4
39liposarcoma10.4
40pancreatitis10.4
41dedifferentiated liposarcoma10.4
42ganglioglioma10.4S100B
43paraganglioma10.4DES, ACTC1
44epithelioid leiomyosarcoma10.3DES, ACTC1
45histiocytosis10.3S100B
46pseudosarcomatous fibromatosis10.3DES, ACTC1
47hepatitis10.3
48pituitary adenoma10.3
49fasting hypoglycemia10.3
50adenosarcoma10.3DES, ACTC1

Graphical network of the top 20 diseases related to Solitary Fibrous Tumor:



Diseases related to solitary fibrous tumor

Symptoms for Solitary Fibrous Tumor

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Symptoms by clinical synopsis from OMIM:

234820

Clinical features from OMIM:

234820

HPO human phenotypes related to Solitary Fibrous Tumor:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 abnormality of the cardiovascular system HP:0001626

Drugs & Therapeutics for Solitary Fibrous Tumor

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Drug clinical trials:

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Search NIH Clinical Center for Solitary Fibrous Tumor

Genetic Tests for Solitary Fibrous Tumor

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Anatomical Context for Solitary Fibrous Tumor

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MalaCards organs/tissues related to Solitary Fibrous Tumor:

32
Kidney, Liver, Thyroid, Spinal cord, Lung, Pancreas, Prostate, Breast, Uterus, Bone, Adrenal gland, Pineal, Thymus, Adipocyte, Cervix, Tongue, Pituitary, Brain, Cerebellum, Heart, Salivary gland, Skin, Tonsil, Endothelial

Animal Models for Solitary Fibrous Tumor or affiliated genes

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MGI Mouse Phenotypes related to Solitary Fibrous Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7PDGFRB, ACTC1, IGF2, DES
2MP:00053848.1IGF2, NAB2, NES, STAT6, ACTC1, PDGFRB
3MP:00053868.0DES, IGF2, NAB2, NES, S100B
4MP:00053918.0IGF2, MUC1, STAT6, PDGFRB
5MP:00053788.0IGF2, NAB2, NES, STAT6, ACTC1, PDGFRB
6MP:00028737.9NAB2, MUC1, ACTC1, PDGFRB, S100B
7MP:00107687.7DES, IGF2, NAB2, NES, STAT6, ACTC1
8MP:00107717.6S100B, PDGFRB, STAT6, MUC1, NAB2, IGF2
9MP:00053767.5DES, IGF2, MUC1, STAT6, ACTC1, PDGFRB

Publications for Solitary Fibrous Tumor

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Articles related to Solitary Fibrous Tumor:

(show top 50)    (show all 588)
idTitleAuthorsYear
1
Nuclear Expression of STAT6 in Dedifferentiated Liposarcomas With a Solitary Fibrous Tumor-like Morphology: A Diagnostic Pitfall. (25075469)
2014
2
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
3
Correlation between clinical features, imaging and pathologic findings in recurrent solitary fibrous tumor of the orbit. (23909414)
2013
4
68Ga DOTATATE PET/CT Imaging of a Solitary Fibrous Tumor of the Nasopharynx. (24152636)
2013
5
Spinal extradural solitary fibrous tumor with retiform and papillary features. (23632234)
2013
6
Solitary fibrous tumor of the accessory parotid gland: a unique case. (23834136)
2013
7
Hepatic solitary fibrous tumor: report of a rare case. (22771653)
2012
8
Huge malignant solitary fibrous tumor of the pleura. (22566249)
2012
9
Paratesticular solitary fibrous tumor: a rare cause of a hypervascular extratesticular mass. (21266569)
2011
10
Delayed liver metastasis of a meningeal solitary fibrous tumor. (22319969)
2011
11
Primary anaplastic solitary fibrous tumor of the tentorium cerebelli. (21696961)
2011
12
Hemangiopericytoma/Solitary fibrous tumor of the oral cavity. (21378362)
2011
13
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
14
Imaging of benign solitary fibrous tumor of the pleura: a pictorial essay. (21139938)
2010
15
Neurofibroma of kidney: an uncommon neoplasm and diagnostic dilemma with solitary fibrous tumor. (21119287)
2010
16
Lines of cell differentiation in solitary fibrous tumor: an ultrastructural and immunohistochemical study of 10 cases. (19929175)
2009
17
Solitary fibrous tumor of the pleura: surgery and clinical course in 18 cases. (19713334)
2009
18
A case of retroperitoneal solitary fibrous tumor associated with hypoglycemia]. (19673425)
2009
19
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. (19319642)
2009
20
Solitary fibrous tumor with giant multinucleated cells in the retroperitoneum - a case report. (22666708)
2009
21
Solitary fibrous tumor of the abdominal wall. (19967496)
2009
22
A malignant solitary fibrous tumor in the retroperitoneum. (18463965)
2008
23
Solitary fibrous tumor in the cervical spine with destructive vertebral involvement: a case report and review of the literature. (18060553)
2008
24
Orbital giant cell angiofibroma recurring as a solitary fibrous tumor. (18645449)
2008
25
Solitary fibrous tumor of the thigh with epithelioid features: a case report. (17577399)
2007
26
Hypoglycemia in a patient with a huge malignant solitary fibrous tumor of the pleura. (17988280)
2007
27
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor. (17455098)
2007
28
Vaginal solitary fibrous tumor: a case report with recurrence after incomplete excision. (17194953)
2007
29
Malignant transformation of a solitary fibrous tumor of the liver and intractable hypoglycemia. (18040628)
2007
30
Solitary fibrous tumor of the lateral ventricle: CT appearances and pathologic correlation with follow-up. (17110682)
2006
31
Solitary fibrous tumor of the pelvis. (16099582)
2006
32
Endonasal endoscopic resection of an ethmoidal solitary fibrous tumor. (16763824)
2006
33
D2-40 staining in sinonasal-type hemangiopericytoma--further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor. (16362413)
2006
34
Extrathoracic solitary fibrous tumor of the pelvic peritoneum with central malignant degeneration on CT and MRI. (16215968)
2005
35
Intrapulmonary solitary fibrous tumor in an eight-year-old male. (15957162)
2005
36
Right atrial solitary fibrous tumor - a new cardiac neoplasm? (17670440)
2005
37
Solitary fibrous tumor of the orbit--two cases and a review of the literature. (15316820)
2005
38
Solitary fibrous tumor of the orbit. (15617311)
2004
39
Malignant solitary fibrous tumor of the meninges. (15014990)
2004
40
Solitary fibrous tumor of the pericardium presenting itself as a pericardial effusion and right ventricular obstruction. (15365524)
2004
41
Solitary fibrous tumor of the tentorium cerebelli. Case report. (15550899)
2004
42
Nasal solitary fibrous tumor arising from the anterior cranial fossa. (16145606)
2004
43
Solitary fibrous tumor of the spinal cord: case report and review of the literature. (15314822)
2004
44
Solitary fibrous tumor of the pleura: a review. (17472272)
2003
45
Solitary fibrous tumor of the oral mucosa--morphological and immunohistochemical profile in the differential diagnosis with hemangiopericytoma. (12676265)
2003
46
Expression and localization of basic fibroblast growth factor and its mRNA in solitary fibrous tumor. (11598621)
2001
47
Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia. (11372615)
2001
48
Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland. (9496542)
1998
49
Solitary fibrous tumor of the meninges. (9561328)
1998
50
Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II. (9589464)
1998

Variations for Solitary Fibrous Tumor

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Expression for genes affiliated with Solitary Fibrous Tumor

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Expression patterns in normal tissues for genes affiliated with Solitary Fibrous Tumor

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Pathways for genes affiliated with Solitary Fibrous Tumor

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Pathways related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ACTC1, DES
29.6ACTC1, IGF2
39.6STAT6, PDGFRB
4
Show member pathways
7.9PDGFRB, STAT6, MUC1, IGF2, DES

Compounds for genes affiliated with Solitary Fibrous Tumor

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Compounds related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol449.9ACTC1, IGF2
2orcein449.5S100B, ACTC1, DES
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4S100B, DES
44-hydroxytamoxifen449.4S100B, STAT6, IGF2
5acetone449.4MUC1, IGF2
6ganglioside449.4DES, NES, PDGFRB
7eosin449.4S100B, MUC1
8biotin44 24 1111.2DES, MUC1, ACTC1
9progestin449.1DES, IGF2, MUC1
10dihydrotestosterone44 28 24 1112.1DES, IGF2, MUC1
11methionine449.1DES, PDGFRB, S100B
12norepinephrine44 24 1111.0S100B, IGF2, DES
13paclitaxel44 50 1110.9IGF2, PDGFRB, S100B
145fluorouracil448.9IGF2, MUC1, PDGFRB
15agar448.9PDGFRB, MUC1, IGF2
16acth448.8S100B, MUC1, IGF2
17acetylcholine44 50 28 24 1112.8DES, NES, S100B
18bromodeoxyuridine448.8S100B, PDGFRB, NES, DES
19actinomycin d448.8DES, IGF2, MUC1, STAT6
20chloramphenicol44 2 50 1111.8IGF2, MUC1, S100B
21ethanol44 50 24 1111.7S100B, MUC1, DES
22s 100448.7DES, MUC1, ACTC1, S100B
23reticulin448.7DES, MUC1, ACTC1, S100B
24wortmannin448.7S100B, PDGFRB, STAT6
25mucicarmine448.7S100B, ACTC1, MUC1, DES
26b 723448.7DES, MUC1, ACTC1, S100B
27ribonucleic acid448.7PDGFRB, ACTC1, MUC1, IGF2
28hematoxylin448.7DES, MUC1, ACTC1, S100B
29steroid448.7DES, IGF2, STAT6, ACTC1, S100B
30formaldehyde44 249.6DES, MUC1, ACTC1, S100B
31matrigel448.6PDGFRB, ACTC1, NES, MUC1
32imatinib44 50 1110.5DES, IGF2, ACTC1, PDGFRB, S100B
33thymidine44 249.5S100B, MUC1, IGF2, DES
34nitric oxide44 24 1110.3S100B, NES, MUC1, DES
35dexamethasone44 50 28 1111.2IGF2, MUC1, STAT6, ACTC1, S100B
36glycogen44 249.2DES, IGF2, MUC1, ACTC1, S100B
37creatinine448.2DES, IGF2, MUC1, ACTC1, S100B
38threonine448.1DES, MUC1, STAT6, PDGFRB, S100B
39cysteine448.0S100B, PDGFRB, MUC1, IGF2, DES
40testosterone44 61 24 1110.7DES, IGF2, MUC1, ACTC1, PDGFRB, S100B
41calcium44 50 24 1110.7DES, MUC1, STAT6, ACTC1, PDGFRB, S100B
42serine447.7DES, IGF2, MUC1, STAT6, PDGFRB, S100B
43oxygen44 248.6DES, MUC1, NES, ACTC1, PDGFRB, S100B
44paraffin447.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
45progesterone44 28 61 24 1111.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
46estrogen447.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
47glucose447.2DES, IGF2, MUC1, NES, ACTC1, PDGFRB
48vegf446.9S100B, DES, IGF2, NAB2, MUC1, NES
49retinoic acid44 247.8DES, IGF2, MUC1, NES, STAT6, ACTC1
50tyrosine446.8DES, IGF2, MUC1, NES, STAT6, ACTC1

GO Terms for genes affiliated with Solitary Fibrous Tumor

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Cellular components related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3S100B, PDGFRB, ACTC1, STAT6, NES, MUC1

Biological processes related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cardiac myofibril assemblyGO:0550039.6PDGFRB, ACTC1
2muscle filament slidingGO:0300499.6DES, ACTC1
3positive regulation of mitosisGO:0458409.5PDGFRB, IGF2
4memoryGO:0076139.1S100B, IGF2
5positive regulation of cell proliferationGO:0082848.9S100B, PDGFRB, IGF2

Products for genes affiliated with Solitary Fibrous Tumor

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Sources for Solitary Fibrous Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet