MCID: SLT008
MIFTS: 46

Solitary Fibrous Tumor malady

Cancer diseases category

Summaries for Solitary Fibrous Tumor

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Solitary fibrous tumor (SFT) is a rare mesenchymal tumor originating in the pleura or at virtually any... more...

MalaCards: Solitary Fibrous Tumor is related to hemangiopericytoma and giant cell tumor. An important gene associated with Solitary Fibrous Tumor is STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced), and among its related pathways are TGF-Beta Pathway and Osteoblast Signaling. The compounds estrogen and orcein have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and skeleton.

Description from OMIM:46 234820

Aliases & Classifications for Solitary Fibrous Tumor

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Sources:
48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
solitary fibrous tumor:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

solitary fibrous tumor 48 46 60


External Ids:

OMIM46 234820
MESH via Orphanet35 D006393
ICD10 via Orphanet26 C49.9
SNOMED-CT via Orphanet57 134335004, 36060005
UMLS via Orphanet61 C0018922

Related Diseases for Solitary Fibrous Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Solitary Fibrous Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1hemangiopericytoma31.3ACTC1, CD34, MUC1, IGF2, DES, F13A1
2giant cell tumor30.8ACTC1, MUC1, DES, F13A1, S100B, VIM
3fibrous meningioma30.6MUC1, S100B
4adenoma30.6ACTC1, MUC1, IGF2, NES, S100A1, CALB2
5meningioma30.6GFAP, CD34, MUC1, IGF2, PDPN, PDGFRB
6sarcoma30.6ACTC1, KDR, KIT, CD34, CD99, MUC1
7pituitary adenoma30.5NES
8lipoma30.5CD34, DES, S100A1
9hepatitis30.4CD99
10synovial sarcoma30.4KIT, MUC1, IGF2, DES, NES, S100B
11astrocytoma30.4KDR, GFAP, NES, PDGFRA, PDGFRB, S100B
12adenocarcinoma30.4ACTC1, KDR, CD34, MUC1, F13A1, NES
13fasciitis30.2ACTC1
14gastrointestinal stromal tumor30.2KIT, PDGFRA
15liposarcoma30.2CD34, DES, CALB2, VIM
16papillary carcinoma30.2ACTC1, MUC1, S100A1, CALB2
17hemangioma30.2ACTC1, KDR, CD34, F13A1, PDPN
18fibrous histiocytoma30.2ACTC1, CD34, DES, F13A1, S100B, VIM
19pleomorphic adenoma30.2ACTC1, GFAP, MUC1, IGF2, DES, S100A1
20malignant peripheral nerve sheath tumor30.2ACTC1, KIT, CD34, MUC1, PDGFRA, S100A1
21angiosarcoma30.2ACTC1, KDR, CD34, MUC1, PDPN, PDGFRA
22leiomyoma30.1ACTC1, KIT, CD34, IGF2, DES, NES
23neurofibroma30.1ACTC1, KIT, CD34, MUC1, F13A1, PDGFRA
24rhabdomyosarcoma30.1ACTC1, CD99, IGF2, DES, NES, PDGFRA
25hypoglycemia10.9
26meningitis10.6
27thyroiditis10.6
28prostatitis10.6
29malignant pleural solitary fibrous tumor10.4
30meninges hemangiopericytoma10.4
31cervicitis10.4
32hypoglycemic coma10.4
33malignant peritoneal solitary fibrous tumor10.4
34spindle cell lipoma10.4
35islet cell tumor10.4
36pancreatitis10.4
37seminal vesicle tumor10.4
38breast myofibroblastoma10.3
39fibrous synovial sarcoma10.3
40hepatitis a10.3
41goiter10.3
42substernal goiter10.1
43cardiac tamponade10.1
44breast hemangiopericytoma10.1
45acute pancreatitis10.1
46benign fibrous mesothelioma10.1
47kidney hemangiopericytoma10.1
48obstructive jaundice10.1
49cerebritis10.1
50dermatofibrosarcoma10.1

Graphical network of the top 20 diseases related to Solitary Fibrous Tumor:



Diseases related to solitary fibrous tumor

Clinical Features for Solitary Fibrous Tumor

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Sources:
46OMIM
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Clinical features from OMIM:

234820

Clinical synopsis from OMIM:

234820

Drugs & Therapeutics for Solitary Fibrous Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Solitary Fibrous Tumor

Drug clinical trials:

Search ClinicalTrials for Solitary Fibrous Tumor

Search NIH Clinical Center for Solitary Fibrous Tumor

Search CenterWatch for Solitary Fibrous Tumor

Genetic Tests for Solitary Fibrous Tumor

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Anatomical Context for Solitary Fibrous Tumor

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Animal Models for Solitary Fibrous Tumor or affiliated genes

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36MGI
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Publications for Solitary Fibrous Tumor

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Genetic Variations for Solitary Fibrous Tumor

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Expression for genes affiliated with Solitary Fibrous Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Solitary Fibrous Tumor

Search GEO for disease gene expression data for Solitary Fibrous Tumor.

Pathways for genes affiliated with Solitary Fibrous Tumor

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore, 49PharmGKB, 59Tocris Bioscience
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Pathways related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2STAT6, IGF2
210.2PDGFRA, PDGFRB
3
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10.2PDGFRA, PDGFRB
4
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10.1ACTC1, DES, VIM
5
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10.1PDGFRA, STAT6, IGF2
610.0PDGFRB, STAT6, KDR
710.0IGF2, PDGFRA, PDGFRB
810.0KDR, PDGFRA, PDGFRB
910.0PDGFRB, PDGFRA, KDR
10
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9.9GFAP, DES, NES, VIM
119.9VIM, PDPN, DES, ACTC1
12
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9.9PDGFRB, PDGFRA, IGF2, KDR
13
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9.8PDGFRB, PDGFRA, KIT, KDR
14
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9.8PDGFRB, PDGFRA, KIT, KDR
159.8PDGFRB, PDGFRA, KIT, KDR
169.7ACTC1, KDR, KIT, IGF2, PDGFRA
17
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9.7S100B, PDGFRB, PDGFRA, KIT, GFAP
18
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9.7PDGFRB, PDGFRA, IGF2, KIT, KDR
19
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9.7PDGFRB, PDGFRA, IGF2, KIT, KDR
20
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9.6PDGFRB, PDGFRA, STAT6, IGF2, KIT, KDR
21
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9.6VIM, PDGFRB, PDGFRA, IGF2, KIT, KDR
22
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9.3VIM, PDGFRB, PDGFRA, STAT6, DES, IGF2
23
Hide members
9.3S100B, PDGFRB, PDGFRA, STAT6, IGF2, KIT

Compounds for genes affiliated with Solitary Fibrous Tumor

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4GFAP, CALB2, F13A1
2orcein4410.4VIM, ACTC1, DES, S100B
3glycogen44 2411.3IGF2, KIT, GFAP, ACTC1
4eosin4410.3VIM, GFAP, MUC1, S100B
5creatinine4410.3GFAP, IGF2, ACTC1
62-methoxyethanol4410.3VIM, IGF2, ACTC1, S100A1
7su66684410.2KDR, PDGFRB, KIT
8toluidine4410.2DES, S100A1, VIM, KIT
9reticulin4410.2ACTC1, VIM, DES, MUC1, GFAP
10pkc 4124410.2PDGFRB, KIT, PDGFRA, KDR
11Pazopanib1110.2PDGFRB, KDR, PDGFRA, KIT
12streptozotocin4410.2NES, GFAP
13Regorafenib1110.2KIT, PDGFRA, PDGFRB, KDR
14sunitinib44 49 1112.2PDGFRA, KIT, KDR, PDGFRB
15acetylcholine44 49 28 11 2414.1NES, GFAP, CALB2, S100A1
16ganglioside4410.1NES, DES, PDGFRB, VIM, GFAP
17glucose4410.1ACTC1, GFAP, MUC1, IGF2, PDGFRB
18zd64744410.1PDGFRB, KIT, KDR
19gefitinib44 49 1112.1KIT, KDR, PDGFRB, VIM, IGF2
20serine4410.1S100B, STAT6, GFAP, DES
21progestin4410.1IGF2, VIM, DES, MUC1, KDR
22dexamethasone44 49 28 1113.0KDR, GFAP, IGF2, STAT6, S100B
23bromodeoxyuridine4410.0GFAP, DES, NES, PDGFRB, S100B, VIM
24biotin44 11 2412.0VIM, DES, S100A1, MUC1, ACTC1
25paclitaxel44 49 1111.9IGF2, KDR, CALB2, PDGFRB, S100B, GFAP
26s 100449.9ACTC1, VIM, MUC1, GFAP, DES, F13A1
27formaldehyde44 2410.9ACTC1, KIT, MUC1, VIM, S100B, DES
28mucicarmine449.9VIM, CALB2, S100B, S100A1, DES, MUC1
29silver449.8S100A1, GFAP, CD34, DES, CALB2, F13A1
30matrigel449.8VIM, KDR, GFAP, MUC1, ACTC1, NES
31agar449.8VIM, GFAP, CD34, MUC1, IGF2, PDGFRB
32methionine449.8PDGFRB, GFAP, KIT, S100B, DES, VIM
33imatinib44 49 1111.8DES, KDR, KIT, IGF2, PDGFRA, ACTC1
34tgf beta1449.7PDGFRB, VIM, KDR, IGF2, PDGFRA
35iron44 2410.7VIM, S100A1, S100B, F13A1, DES, GFAP
36lactate449.7S100B, DES, IGF2, KIT, GFAP, KDR
37b 723449.5MUC1, ACTC1, DES, F13A1, VIM, CALB2
38rapamycin449.5KDR, KIT, IGF2, PDGFRA, PDGFRB, VIM
39testosterone44 59 11 2412.4VIM, CALB2, DES, ACTC1, GFAP, KIT
40choline44 11 2411.4GFAP, NES, CALB2, S100B, VIM
41nitric oxide44 11 2411.4S100B, CALB2, S100A1, KIT, KDR, NES
42cysteine449.4KDR, KIT, GFAP, S100B, S100A1, PDGFRB
43thymidine44 2410.3IGF2, KIT, MUC1, CD34, KDR, DES
44hematoxylin449.0VIM, CALB2, S100B, S100A1, PDPN, F13A1
45calcium44 49 11 2412.0S100B, PDGFRB, ACTC1, CALB2, PDGFRA, F13A1
46progesterone44 59 28 11 2412.8DES, F13A1, NES, PDGFRB, S100A1, S100B
47retinoic acid44 249.7VIM, S100B, S100A1, PDGFRB, PDGFRA, STAT6
48tyrosine448.4CALB2, S100B, S100A1, PDGFRA, PDPN, STAT6
49vegf448.3NES, KDR, ACTC1, GFAP, KIT, NAB2
50paraffin448.0ACTC1, KDR, VIM, CALB2, S100B, GFAP

GO Terms for genes affiliated with Solitary Fibrous Tumor

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16Gene Ontology
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Cellular components related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to plasma membraneGO:03122610.1PDGFRA, PDGFRB
2intermediate filamentGO:0058829.9VIM, NES, DES, GFAP
3apical plasma membraneGO:0163249.8CD34, MUC1, PDPN, PDGFRB
4external side of plasma membraneGO:0098979.5PDGFRA, CD34, KIT, KDR
5cytoplasmGO:0057378.5ACTC1, VIM, CALB2, S100B, PDGFRB, PDGFRA

Biological processes related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular capillary formationGO:07227710.5PDGFRB, PDGFRA
2Bergmann glial cell differentiationGO:06002010.5VIM, GFAP
3positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.4PDGFRB, PDGFRA
4cardiac myofibril assemblyGO:05500310.4ACTC1, PDGFRA, PDGFRB
5positive regulation of phospholipase C activityGO:01086310.4KIT, PDGFRA, PDGFRB
6endothelium developmentGO:00315810.4CD34, KDR
7cell chemotaxisGO:06032610.3PDGFRB, PDGFRA, KIT
8positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.3KIT, PDGFRA, PDGFRB
9muscle filament slidingGO:03004910.3ACTC1, DES, VIM
10stem cell proliferationGO:07208910.3NES, CD34
11retina vasculature development in camera-type eyeGO:06129810.3PDGFRB, PDGFRA
12signal transduction by phosphorylationGO:02301410.3KDR, KIT
13positive regulation of MAPK cascadeGO:04341010.2KDR, KIT, IGF2
14positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.2KDR, KIT, PDGFRA, PDGFRB
15peptidyl-tyrosine phosphorylationGO:01810810.2PDGFRB, PDGFRA, KIT, KDR
16astrocyte developmentGO:01400210.2VIM, GFAP
17positive regulation of vasculogenesisGO:200121410.2KDR, CD34
18response to hyperoxiaGO:05509310.1PDPN, PDGFRB
19regulation of cell shapeGO:00836010.1S100B, PDPN, KIT, KDR
20intermediate filament organizationGO:04510910.1GFAP, VIM
21positive regulation of cell migrationGO:03033510.1PDGFRB, PDGFRA, PDPN, KDR
22protein autophosphorylationGO:04677710.1PDGFRB, PDGFRA, KIT, KDR
23positive regulation of cell proliferationGO:0082849.9S100B, PDGFRB, PDGFRA, IGF2, KIT, KDR
24positive regulation of ERK1 and ERK2 cascadeGO:0703749.7KDR, PDGFRA, PDGFRB

Molecular functions related to Solitary Fibrous Tumor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.3KDR, PDGFRA
2S100 protein bindingGO:04454810.2S100A1, S100B
3vascular endothelial growth factor bindingGO:03808510.2KDR, PDGFRA, PDGFRB
4transmembrane receptor protein tyrosine kinase activityGO:00471410.1PDGFRA, KIT, KDR
5receptor signaling protein tyrosine kinase activityGO:00471610.1KDR, KIT
6platelet-derived growth factor bindingGO:04840710.1PDGFRB, PDGFRA
7structural constituent of cytoskeletonGO:00520010.1GFAP, DES, VIM
8identical protein bindingGO:0428029.9VIM, S100B, S100A1, STAT6, DES
9protein tyrosine kinase activityGO:0047139.7KDR, KIT, PDGFRB

Products for genes affiliated with Solitary Fibrous Tumor

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  • Antibodies
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Sources for Solitary Fibrous Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet