Aliases & Classifications for Somatization Disorder

MalaCards integrated aliases for Somatization Disorder:

Name: Somatization Disorder 12 72 14 69
Polysomatising Disorder 12
Somatisation Disorder 12
Somatoform Disorders 41
Somatoform Disorder 69
Briquet's Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13918
ICD10 32 F45.0 F45 F45.9
ICD9CM 34 300.81
MeSH 41 D013001
UMLS 69 C0520482

Summaries for Somatization Disorder

Disease Ontology : 12 A somatoform disorder that involves persistently complaints of varied physical symptoms that have no identifiable physical origin.

MalaCards based summary : Somatization Disorder, also known as polysomatising disorder, is related to somatoform disorder and episodic pain syndrome, familial, 1, and has symptoms including multiple somatic complaints An important gene associated with Somatization Disorder is DCXR (Dicarbonyl And L-Xylulose Reductase), and among its related pathways/superpathways are Signaling pathways regulating pluripotency of stem cells and Adipogenesis. The drugs Imipramine and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related phenotypes are Increased HDAC inhibitor resistance and growth/size/body region

Wikipedia : 72 Somatization disorder (also Briquet\'s syndrome) is a mental disorder characterized by recurring,... more...

Related Diseases for Somatization Disorder

Graphical network of the top 20 diseases related to Somatization Disorder:



Diseases related to Somatization Disorder

Symptoms & Phenotypes for Somatization Disorder

UMLS symptoms related to Somatization Disorder:


multiple somatic complaints

GenomeRNAi Phenotypes related to Somatization Disorder according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HDAC inhibitor resistance GR00115-A-0 8.62 LIF LIFR

MGI Mouse Phenotypes related to Somatization Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.02 CRH LIF LIFR NDUFS3 SCGB1A1

Drugs & Therapeutics for Somatization Disorder

Drugs for Somatization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imipramine Approved Phase 2 50-49-7 3696
2 Adrenergic Agents Phase 2
3 Neurotransmitter Agents Phase 2
4 Neurotransmitter Uptake Inhibitors Phase 2
5 Antidepressive Agents Phase 2
6 Antidepressive Agents, Tricyclic Phase 2
7 Psychotropic Drugs Phase 2
8 Analgesics

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Treatment of Medically Unexplained Physical Ailments (Somatization Disorder) Completed NCT00050583 Phase 3
2 Treatment of Patients With Longstanding Unexplained Health Complaints Completed NCT00132197 Phase 2, Phase 3
3 Effectiveness of Cognitive-Affective Behavior Therapy for the Treatment of Somatization Disorder Completed NCT00149760 Phase 2
4 Cognitive Behavior Therapy for Somatization Disorder Completed NCT00276887 Phase 2
5 Imipramine Treatment for Patients With Multi-organ Bodily Distress Syndrome Completed NCT01518634 Phase 2 Imipramine treatment;Placebo
6 Effects of Emotional Stimulation on the Stress Levels of Healthy Persons Completed NCT01187797 Phase 1, Phase 2
7 Acceptance and Commitment Therapy for Patients With Multi-organ Bodily Distress Syndrome (Stress-4) Completed NCT01518647
8 Acceptance and Commitment Group Therapy (ACT) for Patients With Health Anxiety Completed NCT01158430
9 Mindfulness-based Cognitive Therapy for Patients With Functional Disorders Completed NCT00497185
10 Treating Emotional Disorders in Primary Care With Psychological Techniques Recruiting NCT01903096 Primary Care Treatment As Usual
11 Assessment of Somatic Symptom Burden Recruiting NCT03321409
12 Acceptance and Commitment Group Therapy for Adolescents With a Range of Functional Somatic Syndromes Recruiting NCT02346071
13 Mindfulness Therapy in Inflammatory Bowel Disease Recruiting NCT02963246

Search NIH Clinical Center for Somatization Disorder

Cochrane evidence based reviews: somatoform disorders

Genetic Tests for Somatization Disorder

Anatomical Context for Somatization Disorder

MalaCards organs/tissues related to Somatization Disorder:

38
Testes, Pituitary, Brain

Publications for Somatization Disorder

Articles related to Somatization Disorder:

(show top 50) (show all 163)
# Title Authors Year
1
Anatomical distance affects cortical-subcortical connectivity in first-episode, drug-naive somatization disorder. ( 28411503 )
2017
2
Somatization disorder among adolescents in southeast Nigeria: a neglected issue. ( 28947913 )
2017
3
Somatization disorder and somatoform symptoms in systematically studied survivors of 10 disasters. ( 28738098 )
2017
4
Clinical significance of increased cerebellar default-mode network connectivity in resting-state patients with drug-naive somatization disorder. ( 27428190 )
2016
5
Decreased Plasma BDNF Levels of Patients with Somatization Disorder. ( 27757131 )
2016
6
Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest. ( 26771948 )
2016
7
Decreased interhemispheric functional connectivity in insula and angular gyrus/supramarginal gyrus: Significant findings in first-episode, drug-naive somatization disorder. ( 26826895 )
2016
8
Abnormal regional homogeneity and its correlations with personality in first-episode, treatment-naive somatization disorder. ( 26026373 )
2015
9
Alterations in white matter integrity in first-episode, treatment-naive patients with somatization disorder. ( 26003450 )
2015
10
Dissociation of regional activity in default mode network in medication-naive, first-episode somatization disorder. ( 24983962 )
2014
11
SYMPTOMATOLOGY AND COMORBIDITY OF SOMATIZATION DISORDER AMONGST GENERAL OUTPATIENTS ATTENDING A FAMILY MEDICINE CLINIC IN SOUTH WEST NIGERIA. ( 26069465 )
2014
12
A study of disability and its correlates in somatization disorder. ( 24655628 )
2014
13
Trauma-related psychiatric comorbidity of somatization disorder among women in eastern Turkey. ( 25214370 )
2014
14
Increased functional connectivity strength of right inferior temporal gyrus in first-episode, drug-naive somatization disorder. ( 25313257 )
2014
15
Mindfulness therapy for somatization disorder and functional somatic syndromes: analysis of economic consequences alongside a randomized trial. ( 23272987 )
2013
16
Effectiveness of group versus individual cognitive-behavioral therapy in patients with abridged somatization disorder: a randomized controlled trial. ( 23788694 )
2013
17
Mindfulness therapy for somatization disorder and functional somatic syndromes: randomized trial with one-year follow-up. ( 23272986 )
2013
18
Caregiver burden and disability in somatization disorder. ( 24119946 )
2013
19
Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. ( 22211322 )
2012
20
Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. ( 22475718 )
2012
21
Pituitary volumes are reduced in patients with somatization disorder. ( 22993528 )
2012
22
From traumatic attachment to somatization disorder. ( 21995353 )
2011
23
Somatization disorder treated with electroconvulsive therapy. ( 21865963 )
2011
24
Hippocampus and amygdalar volumes in patients with somatization disorder. ( 21651951 )
2011
25
The association between Helicobacter Pylori chronic gastritis, psychological trauma and somatization disorder. A case report. ( 21961102 )
2011
26
Perceived social support and life satisfaction in persons with somatization disorder. ( 22174534 )
2010
27
C-reactive protein variations for different chronic somatic disorders. ( 19372230 )
2009
28
Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders. ( 19906238 )
2009
29
Complex post-traumatic stress disorder in patients with somatization disorder. ( 19085532 )
2009
30
Is baroreflex sensitivity really pathological in patients with somatization disorder? Comment on: Laederach-Hofmann et al. (2008). ( 19505528 )
2009
31
Cognitive-affective neuroscience of somatization disorder and functional somatic syndromes: reconceptualizing the triad of depression-anxiety-somatic symptoms. ( 18496475 )
2008
32
Managing somatization disorder. ( 23212087 )
2008
33
Childhood maltreatment in patients with somatization disorder. ( 18330776 )
2008
34
Cognitive-behaviour therapy for patients with Abridged Somatization Disorder (SSI 4,6) in primary care: a randomized, controlled study. ( 18570681 )
2008
35
Are patients with somatization disorder highly suggestible? ( 18028249 )
2008
36
Temperament profiles in women with somatization disorder. ( 17875043 )
2007
37
P300 endogen evoked potentials in somatization disorder: a controlled study. ( 17323226 )
2007
38
Vulvodynia as a possible somatization disorder. More than just an opinion. ( 17393771 )
2007
39
Somatization disorder, a cause of difficult pain: a case report. ( 17601846 )
2007
40
Personality disorders in somatization disorder patients: a controlled study in Spain. ( 17540225 )
2007
41
Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. ( 16864762 )
2006
42
Distinguishing between hypochondriasis and somatization disorder: a review of the existing literature. ( 16899963 )
2006
43
Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorder. ( 15863791 )
2005
44
Episodic ataxia vs somatization disorder. ( 15633862 )
2004
45
Somatization disorder: a practical review. ( 15560311 )
2004
46
The presentation of irritable bowel syndrome in the context of somatization disorder. ( 15354279 )
2004
47
Somatization disorder in young adult population. ( 14757296 )
2004
48
Somatization disorder and cancer: a case history and review. ( 16594404 )
2004
49
Volumes of the caudate nuclei in women with somatization disorder and healthy women. ( 15246456 )
2004
50
Somatization disorder--a defensive waste of NHS resources. ( 15103033 )
2004

Variations for Somatization Disorder

Expression for Somatization Disorder

Search GEO for disease gene expression data for Somatization Disorder.

Pathways for Somatization Disorder

Pathways related to Somatization Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 LIF LIFR
2 11.08 LIF LIFR
3
Show member pathways
10.39 LIF LIFR

GO Terms for Somatization Disorder

Cellular components related to Somatization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CRH LIF LIFR SCGB1A1

Biological processes related to Somatization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.43 CRH LIF LIFR
2 lung development GO:0030324 9.37 CRH LIF
3 female pregnancy GO:0007565 9.32 CRH SCGB1A1
4 response to cytokine GO:0034097 9.16 LIFR SCGB1A1
5 embryo implantation GO:0007566 8.96 LIF SCGB1A1
6 leukemia inhibitory factor signaling pathway GO:0048861 8.62 LIF LIFR

Sources for Somatization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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