MCID: SMT006
MIFTS: 45

Somatoform Disorder malady

Mental diseases, Neuronal diseases categories

Aliases & Classifications for Somatoform Disorder

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Somatoform Disorder, Aliases & Descriptions:

Name: Somatoform Disorder 9 60
Physiological Malfunction Arising from Mental Factor 9 60
 
Psychophysiologic Disorders 60
Psychosomatic Disorder 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Summaries for Somatoform Disorder

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Disease Ontology:9 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.

MalaCards based summary: Somatoform Disorder, also known as physiological malfunction arising from mental factor, is related to anxiety disorder and personality disorder. An important gene associated with Somatoform Disorder is TRPA1 (transient receptor potential cation channel, subfamily A, member 1), and among its related pathways are TRP channels and Biogenic Amine Synthesis. The drug amoxapine and the compounds allicin and urb597 have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are adipose tissue and integument.

Related Diseases for Somatoform Disorder

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Diseases related to Somatoform Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.3TPH1
2personality disorder31.2TTF2, TPH1
3borderline personality disorder31.2TTF2, TPH1
4generalized anxiety disorder30.6TSPO, TPH1
5panic disorder30.6TTF2, TPH1, TSPO, COMT
6irritable bowel syndrome30.5TRPV1, TPH1
7fibromyalgia30.5TSPO, COMT
8obsessive-compulsive disorder30.4TTF2, TPH1, TSPO, COMT
9alexithymia10.5
10dentin sensitivity10.5TRPA1
11cannabis dependence10.5FAAH
12antisocial personality disorder10.5TTF2
13cystitis10.5TRPV1
14intervertebral disc disease10.4IL1B
15hypochondriasis10.4
16hyperphenylalaninemia10.4GCH1, TPH1
17gastric cancer risk after h. pylori infection10.4IL1RN
18somatization disorder10.4
19dengue shock syndrome10.4IL1RN
20attention deficit-hyperactivity disorder10.3COMT
21gastrointestinal system disease10.3TPH1, TRPV1
22chronic pain10.3
23conduct disorder10.3COMT, TTF2
24drug addiction10.3OPRM1
25pulpitis10.2IL1A, TRPV1
26addison's disease10.2TPH1, MC2R
27conversion disorder10.2
28pain disorder10.2
29body dysmorphic disorder10.2
30neurotic disorder10.2
31dissociative disorder10.2
32phobic disorder10.2
33bacterial vaginosis10.2IL1B, IL1A
34migraine10.2TRPV1, COMT, TPH1
35eye disease10.2IL1B, TSPO
36gingival overgrowth10.2IL1B, IL1A
37arthritis10.2IL1A, IL1B
38gingivitis10.2IL1B, IL1A
39cinca syndrome10.1IL1RN, IL1B
40silicosis10.1IL1RN, IL1A
41alopecia areata10.1IL1RN, IL1A
42psoriatic arthritis10.1IL1A, IL1B
43chorioamnionitis10.1IL1B, IL1RN
44withdrawal disorder10.1OPRM1, TSPO
45amnestic disorder10.1TSPO, OPRM1
46toxic shock syndrome10.1IL1B, IL1RN
47interstitial lung disease10.1IL1RN, IL1A
48phobia, specific10.1
49agoraphobia10.1
50adjustment disorder10.1

Graphical network of the top 20 diseases related to Somatoform Disorder:



Diseases related to somatoform disorder

Symptoms for Somatoform Disorder

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Drugs & Therapeutics for Somatoform Disorder

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Drug clinical trials:

Search ClinicalTrials for Somatoform Disorder

Search NIH Clinical Center for Somatoform Disorder

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Somatoform Disorder

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Anatomical Context for Somatoform Disorder

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MalaCards organs/tissues related to Somatoform Disorder:

31
Brain

Animal Models for Somatoform Disorder or affiliated genes

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MGI Mouse Phenotypes related to Somatoform Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.4TPH1, MC2R, OPRM1, TRPV1
2MP:00107717.9TPH1, FAAH, IL1RN, OPRM1, TRPA1, TRPV1
3MP:00053867.7TPH1, MC2R, FAAH, COMT, OPRM1, TRPA1
4MP:00053857.5TPH1, MC2R, IL1RN, IL1B, IL1A, COMT
5MP:00036317.3MC2R, FAAH, IL1B, COMT, OPRM1, TRPA1
6MP:00053977.2OPRM1, COMT, IL1A, IL1B, IL1RN, MC2R
7MP:00053876.7MC2R, IL1RN, IL1B, IL1A, COMT, OPRM1
8MP:00053766.2TRPV1, TPH1, MC2R, FAAH, IL1RN, IL1B

Publications for Somatoform Disorder

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Articles related to Somatoform Disorder:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Effectiveness of psychotherapy for severe somatoform disorder: meta-analysis. (24385460)
2014
2
Effect of aripiprazole augmentation for treatment-resistant somatoform disorder: a case series. (24525655)
2014
3
A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder? (25388965)
2014
4
Fibromyalgia syndrome: a somatoform disorder? (24453056)
2014
5
Relationship between alexithymia and coping strategies in patients with somatoform disorder. (24403835)
2014
6
The spiral aftereffect technique (SAT) can differentiate between depressive and somatoform disorder patients. (24897884)
2014
7
Psychotherapy for severe somatoform disorder: problems with missing studies. (24590981)
2014
8
Is the DSM-5 chapter on somatic symptom disorder any better than DSM-IV somatoform disorder? (25029686)
2014
9
Changes in brain activity of somatoform disorder patients during emotional empathy after multimodal psychodynamic psychotherapy. (23966922)
2013
10
Definition and structure of body-relatedness from the perspective of patients with severe somatoform disorder and their therapists. (22905144)
2012
11
Dysfunctional affect regulation in borderline personality disorder and in somatoform disorder. (22984638)
2012
12
Public familiarity with the terms somatoform disorder and functional disorder in Germany: results from a representative population survey. (22690365)
2012
13
Somatoform disorder and the DSM-V Workgroup's interim proposals: two central issues. (22664310)
2012
14
Prevalence, demographic and clinical characteristics of body dysmorphic disorder among psychiatric outpatients with mood, anxiety or somatoform disorders. (22029732)
2012
15
Hypochondriasis, somatoform disorders, and anxiety disorders: sociodemographic variables, general psychopathology, and naturalistic treatment effects. (22551794)
2012
16
Association of somatoform disorder symptoms with genetic variants potentially involved in the modulation of nociception. (21037510)
2011
17
Course and prediction of somatoform disorder and medically unexplained symptoms in primary care. (21762827)
2011
18
Somatoform disorder after conscious sedation. (22136794)
2011
19
Childhood traumatization by primary caretaker and affect dysregulation in patients with borderline personality disorder and somatoform disorder. (22893813)
2011
20
A suspected case of somatoform disorder successfully treated with an herbal medicine. (21299430)
2011
21
Multimodal psychodynamic psychotherapy induces normalization of reward related activity in somatoform disorder. (21198419)
2011
22
Acoustic neuroma identified after electroconvulsive therapy in a patient with recurrent major depression and undifferentiated somatoform disorder. (20357670)
2010
23
Affect dysregulation in borderline personality disorder and somatoform disorder: differentiating under- and over-regulation. (20545496)
2010
24
Affect dysregulation and dissociation in borderline personality disorder and somatoform disorder: differentiating inhibitory and excitatory experiencing states. (20938867)
2010
25
An investigation of temperamental traits in patients with somatoform disorder: do they belong in the affective spectrum? (19996232)
2009
26
Vulvodynia as a somatoform disorder. (18664054)
2008
27
Facial emotion recognition and alexithymia in adults with somatoform disorders. (18033726)
2008
28
Irritable bowel syndrome: a single gastrointestinal disease or a general somatoform disorder? (18501255)
2008
29
Validity of current somatoform disorder diagnoses: perspectives for classification in DSM-V and ICD-11. (17952015)
2008
30
Relationship between attachment style, parental bonding and alexithymia in adults with somatoform disorders. (19480357)
2008
31
Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trial. (18345715)
2008
32
Somatoform disorder in primary care: course and the need for cognitive-behavioral treatment. (17116951)
2006
33
Breath-holding spells in somatoform disorder. (15387403)
2004
34
Specific somatoform disorder in the general population. (12832596)
2003
35
Somatoform disorder: how good are we at diagnosis? (12474616)
2002
36
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
37
Alexithymia in DSM-IV disorder: comparative evaluation of somatoform disorder, panic disorder, obsessive-compulsive disorder, and depression. (11351112)
2001
38
The McGill Pain Questionnaire in patients with TMJ pain and with facial pain as a somatoform disorder. (11202844)
2000
39
Hemifacial spasm or somatoform disorder--postexcitatory inhibition after transcranial magnetic cortical stimulation as a diagnostic tool. (10987318)
2000
40
Multisomatoform disorder. An alternative to undifferentiated somatoform disorder for the somatizing patient in primary care. (9107152)
1997
41
Neurasthenia, depression and somatoform disorder in a Chinese-Vietnamese woman migrant. (9248680)
1997
42
Alexithymia in somatoform disorder and somatic disease: a comparative study. (8784946)
1996
43
Loin pain and haematuria syndrome: a somatoform disorder. (7493167)
1995
44
Somatoform disorders in non-specific neurogenic thoracic outlet syndrome patients. (8848944)
1995
45
Alexithymia in somatoform disorder patients with chronic pain. (7990060)
1994
46
The Effect of Somatoform Disorder and Paranoid Psychotic Role-Related Dissimulations as a Response Set on the MMPI-2 (9463502)
1994
47
Cases from the aerospace medicine residents' teaching file. Case #42. An aviator with concentration deficit, Lyme disease organic diagnostic evaluation, and a somatoform disorder. (2031643)
1991
48
Somatoform disorder in a psychiatric setting. Systematic comparisons with depression and anxiety disorders. (3411313)
1988
49
Cyproheptadine dependence associated with an atypical somatoform disorder. (3567821)
1987
50
Atypical somatoform disorder following infection in children--a depressive equivalent? (6698941)
1984

Variations for Somatoform Disorder

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Expression for genes affiliated with Somatoform Disorder

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Search GEO for disease gene expression data for Somatoform Disorder.

Pathways for genes affiliated with Somatoform Disorder

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Pathways related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TRPA1, TRPV1
2
Show member pathways
catecholamine biosynthesis36
9.7COMT, TPH1
39.4IL1A, IL1B
49.4IL1A, IL1B
59.4IL1A, IL1B
69.4IL1A, IL1B
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.8IL1A, IL1B, IL1RN
8
Show member pathways
8.8IL1RN, IL1B, IL1A
9
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
8.8IL1RN, IL1B, IL1A
10
Show member pathways
8.6OPRM1, COMT, FAAH, TPH1
11
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.6IL1B, IL1A, OPRM1
128.5IL1A, IL1B, IL1RN, TPH1
13
Show member pathways
8.5MC2R, TSPO, OPRM1, TRPV1
14
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.5TRPV1, TRPA1, OPRM1, IL1B

Compounds for genes affiliated with Somatoform Disorder

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Compounds related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1allicin2810.1TRPA1, TRPV1
2urb5972810.0FAAH, TRPA1
3delta9-tetrahydrocannabinol439.8TSPO, TRPV1, FAAH
4l-amino acid439.8GCH1, TPH1, COMT
5fluvoxamine43 49 1211.7TPH1, COMT, TSPO
6tetrahydrobiopterin43 24 1211.7IL1B, GCH1, TPH1
72-chloroethyl ethyl sulfide439.6IL1A, IL1RN
8auranofin28 43 59 1212.6IL1B, TRPA1, IL1A
9gold sodium thiomalate439.2IL1RN, IL1B, IL1A
10polymyxin b439.1IL1B, IL1RN, IL1A
11opioids499.1COMT, OPRM1
12anandamide59 43 28 2412.1OPRM1, TRPV1, FAAH
13methamphetamine43 49 1211.1TPH1, FAAH, COMT, OPRM1
14lidocaine43 28 1211.1TSPO, OPRM1, TRPV1
15sulfasalazine28 43 49 1212.0IL1B, IL1A, IL1RN
16ns 39843 5910.0IL1A, IL1B, IL1RN
17propofol43 49 1210.9IL1RN, FAAH, OPRM1
18hydrocortisone43 2 59 1211.8IL1A, IL1B, IL1RN, MC2R
19leukotriene b443 59 2410.8TRPV1, IL1B, IL1RN, IL1A
20forskolin43 49 1210.8IL1A, TPH1, MC2R, IL1B, TRPV1
21corticosterone43 59 2410.8IL1B, IL1A, TSPO, IL1RN
22hydrogen43 249.8IL1RN, FAAH, TTF2, TRPV1, COMT
23ascorbic acid43 249.7TPH1, IL1RN, IL1A, COMT, GCH1
24prostaglandin438.7TRPV1, IL1A, IL1RN, IL1B
25neopterin438.7IL1A, GCH1, IL1B, IL1RN, TPH1
26levodopa43 129.6TPH1, OPRM1, GCH1, COMT, TSPO
27cocaine43 129.6IL1A, COMT, TSPO, OPRM1
28ethanol43 49 24 1211.6TTF2, OPRM1, COMT, TRPV1, TPH1
29acth438.6IL1RN, IL1A, IL1B, MC2R
30cyclosporin a43 28 5910.6TSPO, IL1A, TRPV1, TTF2, IL1RN
31indomethacin43 28 59 1211.5IL1A, IL1B, IL1RN, TSPO, FAAH
32gaba438.5IL1A, OPRM1, TSPO, TPH1, TRPV1
33progesterone43 28 59 24 1212.5IL1A, IL1RN, TTF2, TPH1, FAAH
34naloxone43 28 49 1211.4OPRM1, TSPO, IL1A
355-hydroxytryptamine438.4TSPO, TPH1, IL1A, COMT, OPRM1
36dopamine43 28 24 1211.3TRPV1, GCH1, OPRM1, TSPO, COMT, TPH1
37estrogen438.2TPH1, GCH1, TSPO, TTF2, FAAH, IL1RN
38epinephrine43 24 1210.2COMT, OPRM1, IL1RN, GCH1, IL1A
39pge2437.9OPRM1, IL1RN, IL1B, TRPV1, IL1A
40cysteine437.8OPRM1, TRPV1, COMT, IL1RN, TPH1, TTF2
41morphine43 49 28 1210.7IL1RN, COMT, OPRM1, TRPV1, IL1A, TSPO
42nmda43 288.7IL1RN, IL1A, COMT, OPRM1, TRPV1, TSPO
43nitric oxide43 24 129.7TRPV1, TTF2, TPH1, GCH1, IL1A, IL1B
44dexamethasone43 49 28 1210.7IL1A, OPRM1, IL1B, IL1RN, MC2R, TTF2
45testosterone43 59 24 1210.7COMT, OPRM1, TSPO, IL1RN, IL1A, MC2R
46serine437.5IL1RN, IL1A, OPRM1, FAAH, GCH1, TTF2
47norepinephrine43 24 129.5TSPO, OPRM1, GCH1, COMT, IL1A, IL1RN
48calcium43 49 24 1210.5GCH1, OPRM1, IL1RN, TTF2, MC2R, FAAH
49nicotine43 28 49 1210.5TRPV1, TTF2, TPH1, TSPO, IL1A, COMT
50glutamate437.4COMT, TRPV1, OPRM1, TPH1, IL1A, IL1RN

GO Terms for genes affiliated with Somatoform Disorder

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Biological processes related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1thermoceptionGO:005095510.1TRPV1, TRPA1
2response to painGO:00482659.7TRPA1, GCH1, COMT
3ectopic germ cell programmed cell deathGO:00352349.7IL1A, IL1B
4positive regulation of interleukin-2 biosynthetic processGO:00450869.6IL1A, IL1B
5positive regulation vascular endothelial growth factor productionGO:00105759.5IL1A, IL1B
6positive regulation of mitosisGO:00458409.5IL1B, IL1A
7negative regulation of nitric oxide biosynthetic processGO:00450199.4TSPO, OPRM1
8negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.3IL1A, IL1B
9G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.3OPRM1, MC2R
10calcium ion transmembrane transportGO:00705889.3OPRM1, TRPA1, TRPV1
11response to lipopolysaccharideGO:00324969.3GCH1, COMT, IL1RN
12positive regulation of nitric oxide biosynthetic processGO:00454299.1OPRM1, IL1B
13extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.1IL1A, IL1B
14fever generationGO:00016609.1IL1A, IL1B, IL1RN
15response to drugGO:00424939.0TRPA1, COMT, IL1RN, TSPO

Molecular functions related to Somatoform Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051498.8IL1A, IL1B, IL1RN

Products for genes affiliated with Somatoform Disorder

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Sources for Somatoform Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet