MCID: SMT006
MIFTS: 55

Somatoform Disorder malady

Mental diseases, Neuronal diseases categories
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Summaries for Somatoform Disorder

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.

MalaCards: Somatoform Disorder, also known as physiological malfunction arising from mental factor, is related to personality disorder and borderline personality disorder. An important gene associated with Somatoform Disorder is TRPA1 (transient receptor potential cation channel, subfamily A, member 1), and among its related pathways are TRP channels and Biogenic Amine Synthesis. The drug amoxapine and the compounds allicin and urb597 have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related mouse phenotypes are adipose tissue and integument.

Wikipedia:65 A somatic symptom disorder, formerly known as a somatoform disorder, is a mental disorder characterized... more...

Aliases & Classifications for Somatoform Disorder

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Sources:
8Disease Ontology, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

somatoform disorder 8 62
physiological malfunction arising from mental factor 8
psychophysiologic disorders 62
psychosomatic disorder 8


Related Diseases for Somatoform Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Somatoform Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder30.7TTF2, TPH1
2borderline personality disorder30.7TTF2, TPH1
3anxiety disorder30.7TPH1
4panic disorder30.5TTF2, TPH1, TSPO, COMT
5obsessive-compulsive disorder30.3TTF2, TPH1, TSPO, COMT
6generalized anxiety disorder30.2TSPO, TPH1
7irritable bowel syndrome30.2TRPV1, TPH1
8alexithymia10.5
9hypochondriasis10.4
10somatization disorder10.3
11chronic pain10.3
12conversion disorder10.2
13body dysmorphic disorder10.2
14pain disorder10.2
15neurotic disorder10.2
16dissociative disorder10.2
17phobic disorder10.2
18dentin sensitivity10.1TRPA1
19cannabis dependence10.1FAAH
20antisocial personality disorder10.1TTF2
21cystitis10.1TRPV1
22degenerative disc disease10.1IL1B
23hyperphenylalaninemia10.1GCH1, TPH1
24gastric cancer risk after h. pylori infection10.1IL1RN
25dengue shock syndrome10.1IL1RN
26attention deficit hyperactivity disorder10.1COMT
27gastrointestinal system disease10.1TPH1, TRPV1
28conduct disorder10.1COMT, TTF2
29drug addiction10.1OPRM1
30pulpitis10.1IL1A, TRPV1
31fibromyalgia10.1TSPO, COMT
32addison's disease10.1TPH1, MC2R
33major depressive disorder10.0
34agoraphobia10.0
35adjustment disorder10.0
36lyme disease10.0
37post-traumatic stress disorder10.0
38chronic fatigue syndrome10.0
39acoustic neuroma10.0
40neurocirculatory asthenia10.0
41thoracic outlet syndrome10.0
42tabes dorsalis10.0
43social phobia10.0
44dissociative amnesia10.0
45complex regional pain syndrome10.0
46factitious disorder10.0
47neuroma10.0
48specific phobia10.0
49paine syndrome10.0
50hemifacial spasm10.0

Graphical network of the top 20 diseases related to Somatoform Disorder:



Diseases related to somatoform disorder

Symptoms for Somatoform Disorder

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Drugs & Therapeutics for Somatoform Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Somatoform Disorder

Search NIH Clinical Center for Somatoform Disorder

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Somatoform Disorder

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Anatomical Context for Somatoform Disorder

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33MalaCards
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MalaCards organs/tissues related to Somatoform Disorder:

33
Testes, Brain

Animal Models for Somatoform Disorder or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Somatoform Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.4TPH1, MC2R, OPRM1, TRPV1
2MP:00107717.9TPH1, FAAH, IL1RN, OPRM1, TRPA1, TRPV1
3MP:00053867.7TPH1, MC2R, FAAH, COMT, OPRM1, TRPA1
4MP:00053857.5TPH1, MC2R, IL1RN, IL1B, IL1A, COMT
5MP:00036317.3MC2R, FAAH, IL1B, COMT, OPRM1, TRPA1
6MP:00053977.2OPRM1, COMT, IL1A, IL1B, IL1RN, MC2R
7MP:00053876.7MC2R, IL1RN, IL1B, IL1A, COMT, OPRM1
8MP:00053766.2TRPV1, TPH1, MC2R, FAAH, IL1RN, IL1B

Publications for Somatoform Disorder

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Sources:
52PubMed
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Articles related to Somatoform Disorder:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Effectiveness of psychotherapy for severe somatoform disorder: meta-analysis. (24385460)
2014
2
Relationship between alexithymia and coping strategies in patients with somatoform disorder. (24403835)
2014
3
Changes in brain activity of somatoform disorder patients during emotional empathy after multimodal psychodynamic psychotherapy. (23966922)
2013
4
Definition and structure of body-relatedness from the perspective of patients with severe somatoform disorder and their therapists. (22905144)
2012
5
Dysfunctional affect regulation in borderline personality disorder and in somatoform disorder. (22984638)
2012
6
Public familiarity with the terms somatoform disorder and functional disorder in Germany: results from a representative population survey. (22690365)
2012
7
Somatoform disorder and the DSM-V Workgroup's interim proposals: two central issues. (22664310)
2012
8
Prevalence, demographic and clinical characteristics of body dysmorphic disorder among psychiatric outpatients with mood, anxiety or somatoform disorders. (22029732)
2012
9
Hypochondriasis, somatoform disorders, and anxiety disorders: sociodemographic variables, general psychopathology, and naturalistic treatment effects. (22551794)
2012
10
Altered brain activity during emotional empathy in somatoform disorder. (21998038)
2012
11
Rethinking the Psychogenic Model of Complex Regional Pain Syndrome: Somatoform Disorders and Complex Regional Pain Syndrome. (24223338)
2012
12
Association of somatoform disorder symptoms with genetic variants potentially involved in the modulation of nociception. (21037510)
2011
13
Course and prediction of somatoform disorder and medically unexplained symptoms in primary care. (21762827)
2011
14
Somatoform disorder after conscious sedation. (22136794)
2011
15
Childhood traumatization by primary caretaker and affect dysregulation in patients with borderline personality disorder and somatoform disorder. (22893813)
2011
16
A suspected case of somatoform disorder successfully treated with an herbal medicine. (21299430)
2011
17
Multimodal psychodynamic psychotherapy induces normalization of reward related activity in somatoform disorder. (21198419)
2011
18
Acoustic neuroma identified after electroconvulsive therapy in a patient with recurrent major depression and undifferentiated somatoform disorder. (20357670)
2010
19
Affect dysregulation in borderline personality disorder and somatoform disorder: differentiating under- and over-regulation. (20545496)
2010
20
Affect dysregulation and dissociation in borderline personality disorder and somatoform disorder: differentiating inhibitory and excitatory experiencing states. (20938867)
2010
21
An investigation of temperamental traits in patients with somatoform disorder: do they belong in the affective spectrum? (19996232)
2009
22
Vulvodynia as a somatoform disorder. (18664054)
2008
23
Facial emotion recognition and alexithymia in adults with somatoform disorders. (18033726)
2008
24
Irritable bowel syndrome: a single gastrointestinal disease or a general somatoform disorder? (18501255)
2008
25
Validity of current somatoform disorder diagnoses: perspectives for classification in DSM-V and ICD-11. (17952015)
2008
26
Relationship between attachment style, parental bonding and alexithymia in adults with somatoform disorders. (19480357)
2008
27
Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trial. (18345715)
2008
28
Diagnostic classification and demographic features in 283 patients with somatoform disorder. (17472597)
2007
29
Somatoform disorder in primary care: course and the need for cognitive-behavioral treatment. (17116951)
2006
30
Cognitive processing of emotional information in depression, panic, and somatoform disorder. (15709812)
2005
31
Breath-holding spells in somatoform disorder. (15387403)
2004
32
Specific somatoform disorder in the general population. (12832596)
2003
33
Somatoform disorder: how good are we at diagnosis? (12474616)
2002
34
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
35
Alexithymia in DSM-IV disorder: comparative evaluation of somatoform disorder, panic disorder, obsessive-compulsive disorder, and depression. (11351112)
2001
36
The McGill Pain Questionnaire in patients with TMJ pain and with facial pain as a somatoform disorder. (11202844)
2000
37
Hemifacial spasm or somatoform disorder--postexcitatory inhibition after transcranial magnetic cortical stimulation as a diagnostic tool. (10987318)
2000
38
Multisomatoform disorder. An alternative to undifferentiated somatoform disorder for the somatizing patient in primary care. (9107152)
1997
39
Neurasthenia, depression and somatoform disorder in a Chinese-Vietnamese woman migrant. (9248680)
1997
40
Alexithymia in somatoform disorder and somatic disease: a comparative study. (8784946)
1996
41
Loin pain and haematuria syndrome: a somatoform disorder. (7493167)
1995
42
Somatoform disorders in non-specific neurogenic thoracic outlet syndrome patients. (8848944)
1995
43
Alexithymia in somatoform disorder patients with chronic pain. (7990060)
1994
44
The Effect of Somatoform Disorder and Paranoid Psychotic Role-Related Dissimulations as a Response Set on the MMPI-2 (9463502)
1994
45
Cases from the aerospace medicine residents' teaching file. Case #42. An aviator with concentration deficit, Lyme disease organic diagnostic evaluation, and a somatoform disorder. (2031643)
1991
46
Somatoform disorder in a psychiatric setting. Systematic comparisons with depression and anxiety disorders. (3411313)
1988
47
EEG frequency analysis in conversion and somatoform disorder. (3416496)
1988
48
Cyproheptadine dependence associated with an atypical somatoform disorder. (3567821)
1987
49
Atypical somatoform disorder following infection in children--a depressive equivalent? (6698941)
1984
50
'Allergic to everything' or somatoform disorder? (6709812)
1984

Variations for Somatoform Disorder

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Expression for genes affiliated with Somatoform Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Somatoform Disorder

Search GEO for disease gene expression data for Somatoform Disorder.

Pathways for genes affiliated with Somatoform Disorder

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 54R&D Systems, 60Thomson Reuters
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Pathways related to Somatoform Disorder according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TRPA1, TRPV1
2
Show member pathways
catecholamine biosynthesis38
9.7COMT, TPH1
39.4IL1A, IL1B
49.4IL1A, IL1B
59.4IL1A, IL1B
69.4IL1A, IL1B
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.8IL1A, IL1B, IL1RN
8
Show member pathways
8.8IL1RN, IL1B, IL1A
9
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
8.8IL1RN, IL1B, IL1A
10
Show member pathways
8.6OPRM1, COMT, FAAH, TPH1
11
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.6IL1B, IL1A, OPRM1
128.5IL1A, IL1B, IL1RN, TPH1
13
Show member pathways
8.5MC2R, TSPO, OPRM1, TRPV1
14
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.5TRPV1, TRPA1, OPRM1, IL1B

Compounds for genes affiliated with Somatoform Disorder

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Sources:
29IUPHAR, 45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Somatoform Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1allicin2910.1TRPA1, TRPV1
2urb5972910.0FAAH, TRPA1
3delta9-tetrahydrocannabinol459.8TSPO, TRPV1, FAAH
4l-amino acid459.8GCH1, TPH1, COMT
5fluvoxamine45 51 1111.7TPH1, COMT, TSPO
6tetrahydrobiopterin45 24 1111.7IL1B, GCH1, TPH1
72-chloroethyl ethyl sulfide459.6IL1A, IL1RN
8auranofin29 45 61 1112.6IL1B, TRPA1, IL1A
9gold sodium thiomalate459.2IL1RN, IL1B, IL1A
10polymyxin b459.1IL1B, IL1RN, IL1A
11opioids519.1COMT, OPRM1
12anandamide61 45 29 2412.1OPRM1, TRPV1, FAAH
13methamphetamine45 51 1111.1TPH1, FAAH, COMT, OPRM1
14lidocaine45 29 1111.1TSPO, OPRM1, TRPV1
15sulfasalazine29 45 51 1112.0IL1B, IL1A, IL1RN
16ns 39845 6110.0IL1A, IL1B, IL1RN
17propofol45 51 1110.9IL1RN, FAAH, OPRM1
18hydrocortisone45 3 61 1111.8IL1A, IL1B, IL1RN, MC2R
19leukotriene b445 61 2410.8TRPV1, IL1B, IL1RN, IL1A
20forskolin45 51 1110.8IL1A, TPH1, MC2R, IL1B, TRPV1
21corticosterone45 61 2410.8IL1B, IL1A, TSPO, IL1RN
22hydrogen45 249.8IL1RN, FAAH, TTF2, TRPV1, COMT
23ascorbic acid45 249.7TPH1, IL1RN, IL1A, COMT, GCH1
24prostaglandin458.7TRPV1, IL1A, IL1RN, IL1B
25neopterin458.7IL1A, GCH1, IL1B, IL1RN, TPH1
26levodopa45 119.6TPH1, OPRM1, GCH1, COMT, TSPO
27cocaine45 119.6IL1A, COMT, TSPO, OPRM1
28ethanol45 51 24 1111.6TTF2, OPRM1, COMT, TRPV1, TPH1
29acth458.6IL1RN, IL1A, IL1B, MC2R
30cyclosporin a45 29 6110.6TSPO, IL1A, TRPV1, TTF2, IL1RN
31indomethacin45 29 61 1111.5IL1A, IL1B, IL1RN, TSPO, FAAH
32gaba458.5IL1A, OPRM1, TSPO, TPH1, TRPV1
33progesterone45 29 61 24 1112.5IL1A, IL1RN, TTF2, TPH1, FAAH
34naloxone45 29 51 1111.4OPRM1, TSPO, IL1A
355-hydroxytryptamine458.4TSPO, TPH1, IL1A, COMT, OPRM1
36dopamine45 29 24 1111.3TRPV1, GCH1, OPRM1, TSPO, COMT, TPH1
37estrogen458.2TPH1, GCH1, TSPO, TTF2, FAAH, IL1RN
38epinephrine45 24 1110.2COMT, OPRM1, IL1RN, GCH1, IL1A
39pge2457.9OPRM1, IL1RN, IL1B, TRPV1, IL1A
40cysteine457.8OPRM1, TRPV1, COMT, IL1RN, TPH1, TTF2
41morphine45 51 29 1110.7IL1RN, COMT, OPRM1, TRPV1, IL1A, TSPO
42nmda45 298.7IL1RN, IL1A, COMT, OPRM1, TRPV1, TSPO
43nitric oxide45 24 119.7TRPV1, TTF2, TPH1, GCH1, IL1A, IL1B
44dexamethasone45 51 29 1110.7IL1A, OPRM1, IL1B, IL1RN, MC2R, TTF2
45testosterone45 61 24 1110.7COMT, OPRM1, TSPO, IL1RN, IL1A, MC2R
46serine457.5IL1RN, IL1A, OPRM1, FAAH, GCH1, TTF2
47norepinephrine45 24 119.5TSPO, OPRM1, GCH1, COMT, IL1A, IL1RN
48calcium45 51 24 1110.5GCH1, OPRM1, IL1RN, TTF2, MC2R, FAAH
49nicotine45 29 51 1110.5TRPV1, TTF2, TPH1, TSPO, IL1A, COMT
50glutamate457.4COMT, TRPV1, OPRM1, TPH1, IL1A, IL1RN

GO Terms for genes affiliated with Somatoform Disorder

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Sources:
16Gene Ontology
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Biological processes related to Somatoform Disorder according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1thermoceptionGO:05095510.1TRPV1, TRPA1
2response to painGO:0482659.7TRPA1, GCH1, COMT
3ectopic germ cell programmed cell deathGO:0352349.7IL1A, IL1B
4positive regulation of interleukin-2 biosynthetic processGO:0450869.6IL1A, IL1B
5positive regulation vascular endothelial growth factor productionGO:0105759.5IL1A, IL1B
6positive regulation of mitosisGO:0458409.5IL1B, IL1A
7negative regulation of nitric oxide biosynthetic processGO:0450199.4TSPO, OPRM1
8negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.3IL1A, IL1B
9G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.3OPRM1, MC2R
10calcium ion transmembrane transportGO:0705889.3OPRM1, TRPA1, TRPV1
11response to lipopolysaccharideGO:0324969.3GCH1, COMT, IL1RN
12positive regulation of nitric oxide biosynthetic processGO:0454299.1OPRM1, IL1B
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.1IL1A, IL1B
14fever generationGO:0016609.1IL1A, IL1B, IL1RN
15response to drugGO:0424939.0TRPA1, COMT, IL1RN, TSPO

Molecular functions related to Somatoform Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051498.8IL1A, IL1B, IL1RN

Products for genes affiliated with Somatoform Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Somatoform Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet