MCID: SMT006
MIFTS: 52

Somatoform Disorder malady

Neuronal diseases category

Summaries for Somatoform Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.

MalaCards: Somatoform Disorder, also known as physiological malfunction arising from mental factor, is related to anxiety disorder and personality disorder. An important gene associated with Somatoform Disorder is TRPA1 (transient receptor potential cation channel, subfamily A, member 1), and among its related pathways are B cell receptor signaling pathway and Interleukin-1 processing. The drug amoxapine and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related mouse phenotypes are integument and behavior/neurological.

Wikipedia:63 A somatic symptom disorder, formerly known as a somatoform disorder, is a mental disorder characterized... more...

Aliases & Classifications for Somatoform Disorder

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

somatoform disorder 8 60
physiological malfunction arising from mental factor 8
psychophysiologic disorders 60
psychosomatic disorder 8


Related Diseases for Somatoform Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Somatoform Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder30.6TPH1
2personality disorder30.6TPH1, TTF2
3borderline personality disorder30.5TPH1, TTF2
4panic disorder30.5COMT, TTF2, TSPO, TPH1
5generalized anxiety disorder30.2TSPO, TPH1
6obsessive-compulsive disorder30.2COMT, TTF2, TSPO, TPH1
7irritable bowel syndrome30.0TRPV1, TPH1
8psychotic disorder30.0COMT, OPRM1, TTF2, TPH1
9pain disorder10.5
10alexithymia10.5
11somatization disorder10.5
12hypochondriasis10.4
13conversion disorder10.2
14body dysmorphic disorder10.2
15dissociative disorder10.2
16major depressive disorder10.2
17neurotic disorder10.2
18factitious disorder10.2
19phobic disorder10.2
20tabes dorsalis10.0
21social phobia10.0
22atypical depressive disorder10.0
23dissociative amnesia10.0
24adjustment disorder10.0
25agoraphobia10.0
26lyme disease10.0
27post-traumatic stress disorder10.0
28chronic fatigue syndrome10.0
29acoustic neuroma10.0
30neurocirculatory asthenia10.0
31thoracic outlet syndrome10.0
32complex regional pain syndrome10.0
33mood disorder10.0
34neuroma10.0
35physical disorder10.0
36specific phobia10.0
37psychogenic movement10.0
38kearns-sayre syndrome10.0
39blindness10.0TSPO
40stroke, ischemic10.0TSPO
41multiple system atrophy10.0TSPO
42hyperglycemia10.0TTF2
43neuropathy10.0TRPV1
44colon cancer10.0TTF2
45gastroesophageal reflux disease10.0TRPV1
46cannabis dependence10.0FAAH
47allergic rhinitis10.0TRPV1
48hepatocellular carcinoma10.0TSPO
49sudden infant death syndrome10.0TPH1
50dentin sensitivity10.0TRPA1

Graphical network of the top 20 diseases related to Somatoform Disorder:



Diseases related to somatoform disorder

Clinical Features for Somatoform Disorder

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Drugs & Therapeutics for Somatoform Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Somatoform Disorder

Drug clinical trials:

Search ClinicalTrials for Somatoform Disorder

Search NIH Clinical Center for Somatoform Disorder

Search CenterWatch for Somatoform Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Somatoform Disorder

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Anatomical Context for Somatoform Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Somatoform Disorder:

32
Testes, Brain

Animal Models for Somatoform Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Somatoform Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.7FAAH, OPRM1, TRPA1, TPH1
2MP:00053867.7TPH1, MC2R, TRPV1, TRPA1, OPRM1, FAAH
3MP:00053876.4COMT, OPRM1, TRPA1, TRPV1, MC2R, IL1RN
4MP:00053765.9TPH1, COMT, FAAH, OPRM1, TRPA1, TRPV1

Publications for Somatoform Disorder

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Sources:
50PubMed
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Articles related to Somatoform Disorder:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Relationship between alexithymia and coping strategies in patients with somatoform disorder. (24403835)
2014
2
Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study. (22894821)
2013
3
Definition and structure of body-relatedness from the perspective of patients with severe somatoform disorder and their therapists. (22905144)
2012
4
Public familiarity with the terms somatoform disorder and functional disorder in Germany: results from a representative population survey. (22690365)
2012
5
A Comparative Study on Alexithymia in Depressive, Somatoform, Anxiety, and Psychotic Disorders among Koreans. (23251195)
2012
6
Presentation of the Multidisciplinary Guideline Medically Unexplained Physical Symptoms (MUPS) and Somatoform Disorder in the Netherlands: disease management according to risk profiles. (22281461)
2012
7
The grapes of war. Somatoform pain disorder and history of early war traumatization in older people. (22782661)
2012
8
Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder. (22697203)
2012
9
Validation of the PHQ-15 for somatoform disorder in the occupational health care setting. (21785907)
2012
10
Childhood traumatization by primary caretaker and affect dysregulation in patients with borderline personality disorder and somatoform disorder. (22893813)
2011
11
A suspected case of somatoform disorder successfully treated with an herbal medicine. (21299430)
2011
12
Multimodal psychodynamic psychotherapy induces normalization of reward related activity in somatoform disorder. (21198419)
2011
13
Dysfunctional pain modulation in somatoform pain disorder patients. (20924589)
2011
14
Affect dysregulation in borderline personality disorder and somatoform disorder: differentiating under- and over-regulation. (20545496)
2010
15
Shared neural activity in panic disorder and undifferentiated somatoform disorder compared with healthy controls. (20673555)
2010
16
Memory performance related to organic and psychosocial illness attributions in somatoform pain disorder patients. (19686875)
2009
17
A randomized double-blind clinical trial on analgesic efficacy of fluoxetine for persistent somatoform pain disorder. (19733606)
2009
18
Facial emotion recognition and alexithymia in adults with somatoform disorders. (19016461)
2009
19
Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. (17723312)
2008
20
Redefining (somatoform) pain disorder in ICD-10: a compromise of different interest groups in Germany. (18332667)
2008
21
Irritable bowel syndrome: a single gastrointestinal disease or a general somatoform disorder? (18501255)
2008
22
Relationship between attachment style, parental bonding and alexithymia in adults with somatoform disorders. (19480357)
2008
23
Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trial. (18345715)
2008
24
The relationship between alexithymia and salivary cortisol levels in somatoform disorders. (18752108)
2008
25
Somatoform dissociation in depersonalization disorder. (19042782)
2008
26
High prevalence of restless legs syndrome in somatoform pain disorder. (16917680)
2007
27
Complaints of loss of personal memories after electroconvulsive therapy: evidence of a somatoform disorder? (17600164)
2007
28
Actual neurosis as the underlying psychic structure of panic disorder, somatization, and somatoform disorder: an integration of Freudian and attachment perspectives. (18085013)
2007
29
Abnormality in the self-monitoring mechanism in patients with fibromyalgia and somatoform pain disorder. (15673632)
2005
30
Randomized double-blind comparison of serotonergic (Citalopram) versus noradrenergic (Reboxetine) reuptake inhibitors in outpatients with somatoform, DSM-IV-TR pain disorder. (15629872)
2005
31
Breath-holding spells in somatoform disorder. (15387403)
2004
32
Why do doctors dislike treating people with somatoform disorder? (15715757)
2004
33
Determinants of health-related quality of life in patients with persistent somatoform pain disorder. (12935799)
2003
34
Specific somatoform disorder in the general population. (12832596)
2003
35
"Free-floating" somatoform disorder. (12954921)
2003
36
Pain in somatoform disorders: is somatoform pain disorder a valid diagnosis? (12121207)
2002
37
Treatment of functional impairment in severe somatoform pain disorder: a case example. (11553697)
2001
38
Alexithymia in DSM-IV disorder: comparative evaluation of somatoform disorder, panic disorder, obsessive-compulsive disorder, and depression. (11351112)
2001
39
Hemifacial spasm or somatoform disorder--postexcitatory inhibition after transcranial magnetic cortical stimulation as a diagnostic tool. (10987318)
2000
40
Chronic pelvic pain as a somatoform disorder. (10026460)
1999
41
Use of the label "litigation neurosis" in patients with somatoform pain disorder. (9582593)
1998
42
Multisomatoform disorder. An alternative to undifferentiated somatoform disorder for the somatizing patient in primary care. (9107152)
1997
43
Neurasthenia, depression and somatoform disorder in a Chinese-Vietnamese woman migrant. (9248680)
1997
44
Alterations of benzodiazepine receptor binding potential in anxiety and somatoform disorders measured by 123I-iomazenil SPECT. (9278373)
1997
45
Alexithymia in somatoform disorder and somatic disease: a comparative study. (8784946)
1996
46
Alexithymia in somatoform disorder patients with chronic pain. (7990060)
1994
47
Cases from the aerospace medicine residents' teaching file. Case #42. An aviator with concentration deficit, Lyme disease organic diagnostic evaluation, and a somatoform disorder. (2031643)
1991
48
Does addition of low-dose flupentixol enhance the analgetic effects of low-dose amitriptyline in somatoform pain disorder? (1771090)
1991
49
Effectiveness of treatment for somatoform disorder patients. (1749838)
1991
50
Cyproheptadine dependence associated with an atypical somatoform disorder. (3567821)
1987

Genetic Variations for Somatoform Disorder

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Expression for genes affiliated with Somatoform Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Somatoform Disorder

Search GEO for disease gene expression data for Somatoform Disorder.

Pathways for genes affiliated with Somatoform Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Somatoform Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4OPRM1, IL1A
29.2IL1B, IL1A
3
Hide members
8.7IL1A, IL1B, IL1RN
4
Hide members
8.7IL1RN, IL1A, IL1B
5
Immune response Bacterial infections in normal airways
Hide members
8.7IL1B, IL1RN, IL1A
68.4TPH1, IL1RN, IL1A, IL1B

Compounds for genes affiliated with Somatoform Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Somatoform Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1pge24410.4TRPV1
2estrogen4410.3TPH1, GCH1
3urb5972810.2FAAH, TRPA1
4tetrahydrobiopterin44 11 2412.2GCH1, TPH1
5allicin2810.2TRPA1, TRPV1
6delta9-tetrahydrocannabinol4410.0TRPV1, FAAH, TSPO
7forskolin44 49 1111.9MC2R, TRPV1
82-chloroethyl ethyl sulfide449.8IL1RN, IL1A
9cyclosporin a44 28 5911.8TSPO, TTF2, TRPV1
10l-amino acid449.8TPH1, GCH1, COMT
11methamphetamine44 49 1111.7FAAH, OPRM1, TPH1
12dexamethasone44 49 28 1112.7OPRM1, MC2R
13lidocaine44 28 1111.5TSPO, TRPV1, OPRM1
14hydrogen44 2410.4COMT, FAAH, TRPV1, TTF2
15anandamide44 28 59 2412.4FAAH, OPRM1, TRPV1
16norepinephrine44 11 2411.4TPH1, GCH1, OPRM1, TSPO
17auranofin44 59 28 1112.3IL1A, IL1B, TRPA1
18muramyl tripeptide449.3IL1A, IL1B
19propofol44 49 1111.3OPRM1, FAAH, IL1RN
20naloxone44 49 28 1112.2OPRM1, IL1A, TSPO
21nmda44 2810.2OPRM1, TSPO, COMT, TRPV1
22mptp449.1TSPO, COMT, GCH1
23gold sodium thiomalate449.1IL1A, IL1B, IL1RN
24cocaine44 1110.1TSPO, IL1A, OPRM1, COMT
25polymyxin b449.0IL1B, IL1A, IL1RN
26sulfasalazine44 28 49 1112.0IL1A, IL1RN, IL1B
27levodopa44 1110.0COMT, GCH1, OPRM1, TSPO, TPH1
28ns 39844 599.9IL1A, IL1RN, IL1B
29glutamate448.9TSPO, TPH1, TRPV1, COMT, OPRM1
30ascorbic acid44 249.9IL1A, GCH1, COMT, TPH1, IL1RN
31gaba448.9TRPV1, OPRM1, IL1A, TPH1, TSPO
32ethanol44 49 11 2411.9TRPV1, TPH1, TTF2, OPRM1, COMT
335-hydroxytryptamine448.8IL1A, TSPO, TPH1, COMT, OPRM1
34corticosterone44 59 2410.8IL1B, IL1A, TSPO, IL1RN
35il 10448.7IL1B, IL1RN, IL1A
36leukotriene b444 59 2410.7TRPV1, IL1RN, IL1A, IL1B
37ivig448.7IL1RN, IL1A, IL1B
38dopamine44 28 11 2411.6TRPV1, OPRM1, GCH1, COMT, TPH1, TSPO
39prostaglandin448.5TRPV1, IL1B, IL1RN, IL1A
40epinephrine44 11 2410.5COMT, OPRM1, GCH1, IL1RN, IL1A
41hydrocortisone44 2 59 1111.5MC2R, IL1RN, IL1A, IL1B
42indomethacin44 59 28 1111.5IL1B, IL1RN, FAAH, TSPO, IL1A
43neopterin448.5IL1B, TPH1, GCH1, IL1RN, IL1A
44morphine44 49 28 1111.2TSPO, OPRM1, IL1A, IL1RN, TRPV1, COMT
45serine448.2TTF2, IL1A, IL1RN, TRPV1, OPRM1
46testosterone44 59 11 2411.0TSPO, IL1RN, IL1A, MC2R, OPRM1, COMT
47nicotine44 49 28 1110.9IL1A, TSPO, OPRM1, TPH1, COMT, TRPV1
48cysteine447.8COMT, IL1RN, OPRM1, TRPV1, TPH1, TTF2
49nitric oxide44 11 249.5GCH1, FAAH, TRPV1, IL1RN, IL1B, IL1A
50calcium44 49 11 2410.4MC2R, TRPV1, OPRM1, FAAH, TTF2, TPH1

GO Terms for genes affiliated with Somatoform Disorder

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Sources:
16Gene Ontology
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Biological processes related to Somatoform Disorder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1thermoceptionGO:05095510.0TRPV1, TRPA1
2response to painGO:0482659.6TRPA1, GCH1, COMT
3negative regulation of nitric oxide biosynthetic processGO:0450199.6OPRM1, TSPO
4fever generationGO:0016609.3IL1B, IL1A
5negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.2IL1B, IL1A
6positive regulation of interleukin-2 biosynthetic processGO:0450869.1IL1A, IL1B
7response to drugGO:0424939.1TSPO, TRPA1, COMT, IL1RN
8positive regulation vascular endothelial growth factor productionGO:0105758.9IL1A, IL1B

Molecular functions related to Somatoform Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051498.7IL1B, IL1A, IL1RN

Products for genes affiliated with Somatoform Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Somatoform Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet