MCID: SPC001
MIFTS: 29

Space Motion Sickness malady

Categories: Ear diseases

Aliases & Classifications for Space Motion Sickness

Aliases & Descriptions for Space Motion Sickness:

Name: Space Motion Sickness 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4796
MeSH 42 D018489
SNOMED-CT 64 21162009
UMLS 69 C0242700

Summaries for Space Motion Sickness

MalaCards based summary : Space Motion Sickness is related to motion sickness and glossopharyngeal nerve neoplasm. An important gene associated with Space Motion Sickness is CHIT1 (Chitinase 1), and among its related pathways/superpathways is Gastric acid production. The drugs Histamine and Diphenhydramine have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and brain.

Related Diseases for Space Motion Sickness

Diseases related to Space Motion Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 motion sickness 10.7
2 glossopharyngeal nerve neoplasm 10.3 AVP REN
3 gastrointestinal neuroendocrine benign tumor 10.3 CCK SCT
4 choline deficiency disease 10.3 NTS VIP
5 mixed lacrimal gland cancer 10.2 AVP CHIT1 FOS
6 pellagra 10.2 AVP CCK
7 post-vaccinal encephalitis 10.2 GAST SCT
8 cervical carcinosarcoma 10.2 CCK FOS NTS
9 nontoxic goiter 10.2 FUT2 VIP
10 paranasal sinus cancer, adult 10.2 GAST NTS
11 progressive relapsing multiple sclerosis 10.1 GAST NTS SCT
12 volkmann contracture 10.1 GAST NTS VIP
13 acute pyelonephritis 10.1 GAST SCT VIP
14 maturity-onset diabetes of the young, type 13 10.1 GAST SCT VIP
15 nutritional optic neuropathy 10.1 GAST MLN
16 benign shuddering attacks 10.1 GAST SCT VIP
17 hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10.1 CCK GAST NTS
18 retinal vascular occlusion 10.1 CCK GAST SCT
19 endocrine gland cancer 10.1 CCK GAST NTS
20 gmppa-cdg 10.1 SCT VIP
21 ischemic neuropathy 10.0 CCK GAST MLN
22 childhood intracortical osteosarcoma 10.0 CCK GAST MLN
23 chondroma 10.0 AVP CCK PPY SCT
24 mitochondrial dna depletion syndrome 5 10.0 AVP GAST VIP
25 transsexualism 10.0 AVP MGAM REN
26 cherubism 10.0 GAST PPY
27 astroblastoma 10.0 AVP MGAM REN
28 adenocarcinoma 10.0 MGAM REN
29 eccrine papillary adenocarcinoma 10.0 GAST PPY SCT
30 childhood malignant hemangiopericytoma 10.0 CCK GAST MLN SCT
31 tricuspid valve stenosis 9.9 CCK GAST MLN NTS SCT
32 breast malignant eccrine spiradenoma 9.9 CCK GAST PPY SCT
33 sweat gland cancer 9.9 CCK GAST MLN NTS VIP
34 gastric duplication cysts 9.9 GAST PPY
35 gemistocytic astrocytoma 9.8 CCK GAST PPY SCT VIP
36 neuronitis 9.8
37 typhoid fever 9.7 CCK GAST MGAM
38 myocardial stunning 9.7 CCK GAST MGAM MLN
39 adult brain stem glioma 7.8 AVP CCK CHIT1 CNOT2 FGF2 FOS

Graphical network of the top 20 diseases related to Space Motion Sickness:



Diseases related to Space Motion Sickness

Symptoms & Phenotypes for Space Motion Sickness

Drugs & Therapeutics for Space Motion Sickness

Drugs for Space Motion Sickness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
2
Diphenhydramine Approved Phase 4 58-73-1, 147-24-0 3100
3
Promethazine Approved Phase 4 60-87-7 4927
4
Histamine Phosphate Phase 4 51-74-1 65513
5 Gastrointestinal Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 Histamine Antagonists Phase 4
8 Histamine H1 Antagonists Phase 4
9 Dermatologic Agents Phase 4
10 Anesthetics Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Anesthetics, Local Phase 4
13 Anti-Allergic Agents Phase 4
14 Hypnotics and Sedatives Phase 4
15 Antiemetics Phase 4
16 Autonomic Agents Phase 4
17 Central Nervous System Depressants Phase 4
18 Antipruritics Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Suspended NCT02136420 Phase 4
2 Prospective Study for Safety and Efficacy of InSpace™ in Rotator Cuff Tear Subjects Completed NCT00916994
3 Effects of Inverted Vision on Pointing and Grasping in Parabolic Flight Recruiting NCT02885844
4 Influence of Gravity on the Perception of Egocentric Distance (Blindpulling) Recruiting NCT02508545
5 Parabolic Flight Induced Neuroplasticity Studied With Advanced Magnetic Resonance Imaging Methods Recruiting NCT02517216

Search NIH Clinical Center for Space Motion Sickness

Cochrane evidence based reviews: space motion sickness

Genetic Tests for Space Motion Sickness

Anatomical Context for Space Motion Sickness

MalaCards organs/tissues related to Space Motion Sickness:

39
Testes, Eye, Brain, Hypothalamus

Publications for Space Motion Sickness

Articles related to Space Motion Sickness:

(show top 50) (show all 76)
id Title Authors Year
1
Subjective Vertical Conflict Theory and Space Motion Sickness. ( 26802378 )
2016
2
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment. ( 25647233 )
2015
3
Microgravity Simulated by the 6A^ Head-Down Tilt Bed Rest Test Increases Intestinal Motility but Fails to Induce Gastrointestinal Symptoms of Space Motion Sickness. ( 26055239 )
2015
4
Space motion sickness countermeasures: a pharmacological double-blind, placebo-controlled study. ( 24919385 )
2014
5
Space motion sickness and motion sickness: symptoms and etiology. ( 23855067 )
2013
6
A rationale for space motion sickness. ( 21485406 )
2011
7
A re-investigation of the role of utricular asymmetries in Space Motion Sickness. ( 21558639 )
2011
8
A rationale for space motion sickness. ( 21748915 )
2011
9
Space motion sickness: incidence, etiology, and countermeasures. ( 16935570 )
2006
10
Space motion sickness. ( 17021896 )
2006
11
Preflight virtual reality training as a countermeasure for space motion sickness and disorientation. ( 15828634 )
2005
12
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. ( 15354005 )
2004
13
Effects of drug countermeasures for space motion sickness on working memory in humans. ( 15451046 )
2004
14
Squirrel monkeys and space motion sickness. ( 12047798 )
2002
15
Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness. ( 12528715 )
2002
16
Emesis and space motion sickness in amphibians. ( 11542850 )
2000
17
Relationship between selected orientation rest frame, circular vection and space motion sickness. ( 10052580 )
1998
18
The relative roles of the otolith organs and semicircular canals in producing space motion sickness. ( 9416590 )
1998
19
Managing space motion sickness. ( 9416592 )
1998
20
Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness. ( 9177562 )
1997
21
Development of space motion sickness in a ground-based human centrifuge. ( 11540754 )
1996
22
Space motion sickness. ( 7741942 )
1995
23
Preflight adaptation training for spatial orientation and space motion sickness. ( 8083393 )
1994
24
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. ( 11537946 )
1994
25
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility. ( 11539508 )
1994
26
Psychophysiological aspects of increasing resistance to space motion sickness. ( 11538510 )
1993
27
A predictive test for space motion sickness. ( 8275263 )
1993
28
Treatment efficacy of intramuscular promethazine for space motion sickness. ( 8447805 )
1993
29
Comparison of treatment strategies for Space Motion Sickness. ( 11541638 )
1993
30
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. ( 1546939 )
1992
31
Comparison of treatment strategies for Space Motion Sickness. ( 11541442 )
1992
32
Electrical vestibular stimulation and space motion sickness. ( 11540742 )
1992
33
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. ( 1599177 )
1992
34
Ocular torsion as a test of the asymmetry hypothesis of space motion sickness. ( 11537575 )
1992
35
New pharmacologic approaches to the prevention of space/motion sickness. ( 1662231 )
1991
36
Altered sensorimotor control of the body as an etiological factor in space motion sickness. ( 1930058 )
1991
37
Prediction of space motion sickness susceptibility by disconjugate eye torsion in parabolic flight. ( 2012564 )
1991
38
Sensory interaction and methods of non-medicinal prophylaxis of space motion sickness. ( 2047451 )
1991
39
Oculomotor function during space flight and susceptibility to space motion sickness. ( 11537148 )
1991
40
Space motion sickness, hearing loss, and bifocals meet their match in vestibular system's plasticity. ( 1880859 )
1991
41
The involvement of cerebrovascular reactivity in pathogenesis of space motion sickness. ( 11537154 )
1991
42
Otolith function in hypo- and hypergravity: relation to space motion sickness. ( 1927373 )
1991
43
Instability of ocular torsion in zero gravity: possible implications for space motion sickness. ( 2241730 )
1990
44
Space motion sickness. ( 2197405 )
1990
45
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 2748293 )
1989
46
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 11537411 )
1989
47
Space motion sickness during 24 flights of the space shuttle. ( 3240221 )
1988
48
Comparison of aerobic fitness and space motion sickness during the shuttle program. ( 3390102 )
1988
49
Neurohumoral mechanism of space motion sickness. ( 11542422 )
1988
50
The use of the logistic model in space motion sickness prediction. ( 3675512 )
1987

Variations for Space Motion Sickness

Expression for Space Motion Sickness

Search GEO for disease gene expression data for Space Motion Sickness.

Pathways for Space Motion Sickness

Pathways related to Space Motion Sickness according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 9.77 CCK GAST SCT VIP

GO Terms for Space Motion Sickness

Cellular components related to Space Motion Sickness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP CCK CHIT1 FGF2 GAST PPY
2 extracellular region GO:0005576 9.4 AVP CCK CHIT1 FGF2 GAST MLN

Biological processes related to Space Motion Sickness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to immobilization stress GO:0035902 9.16 FOS REN
2 regulation of blood vessel size GO:0050880 8.96 AVP NTS
3 positive regulation of glutamate secretion GO:0014049 8.62 AVP CCK

Molecular functions related to Space Motion Sickness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.35 AVP CCK NTS PPY VIP
2 hormone activity GO:0005179 9.17 AVP CCK GAST MLN PPY SCT

Sources for Space Motion Sickness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....