MCID: SPC001
MIFTS: 26

Space Motion Sickness malady

Category: Ear diseases

Aliases & Classifications for Space Motion Sickness

About this section

Aliases & Descriptions for Space Motion Sickness:

Name: Space Motion Sickness 11 38 13 67

Classifications:



External Ids:

Disease Ontology11 DOID:4796
SNOMED-CT61 21162009
MeSH38 D018489

Summaries for Space Motion Sickness

About this section
MalaCards based summary: Space Motion Sickness is related to motion sickness and neuronitis, and has symptoms including vomiting An important gene associated with Space Motion Sickness is CHIT1 (Chitinase 1), and among its related pathways is G alpha (s) signalling events. Affiliated tissues include testes, eye and hypothalamus.

Related Diseases for Space Motion Sickness

About this section

Diseases related to Space Motion Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1motion sickness10.7
2neuronitis9.8
3typhoidal tularemia9.7AVP, NTS
4neuronal ceroid lipofuscinosis9.6NTS, SCT
5pancreatic cystadenocarcinoma9.5NTS, SCT
6autoimmune-related retinopathy and optic neuropathy9.5NTS, SCT
7primary progressive multiple sclerosis9.3NTS, SCT
8aggressive systemic mastocytosis8.3AVP, CHIT1, FUT2, NTS, SCT

Graphical network of diseases related to Space Motion Sickness:



Diseases related to space motion sickness

Symptoms for Space Motion Sickness

About this section

UMLS symptoms related to Space Motion Sickness:


vomiting

Drugs & Therapeutics for Space Motion Sickness

About this section

Drugs for Space Motion Sickness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Histamine PhosphateapprovedPhase 4103351-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
2
PromethazineapprovedPhase 422560-87-74927
Synonyms:
(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
(Dimethylamino-2-propyl-10-phenothiazine hydrochloride
10-(2-(Dimethylamino)-2-methylethyl)phenothiazine
10-(2-(Dimethylamino)propyl)phenothiazine
10-(2-Dimethylaminopropyl)phenothiazine
10-[2-(Dimethylamino)propyl]phenothiazine
10-[2-(dimethylamino)Propyl]phenothiazine
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl- (9CI)
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, radical ion(1+)
3277 RP
3389 R.p.
38878-40-9
4-27-00-01253 (Beilstein Handbook Reference)
4182 R.p.
60-87-7
73745-50-3
A-91033
AB00053535
AC-15939
AC1L1J92
Antiallersin
Aprobit
Avomine
BPBio1_000744
BRN 0088554
BSPBio_000676
BSPBio_002777
C07404
CCRIS 7056
CHEBI:8461
CHEMBL643
CID4927
Camergan
D00494
DB01069
Dimapp
Dimethylamino-isopropyl-phenthiazin
Dimethylamino-isopropyl-phenthiazin [German]
Diphergan
Diprazin
Diprazine
Diprozin
DivK1c_000005
EINECS 200-489-2
Fargan
Fenazil
Fenetazina
Fenetazine
Genphen
HMS2089E08
HSDB 3173
Hiberna
Histargan
IDI1_000005
Iergigan
InChI=1/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
Isophenergan
Isopromethazine
KBio1_000005
KBio2_001348
KBio2_003916
KBio2_006484
KBio3_001997
KBioGR_001697
KBioSS_001348
L000495
LS-264
Lercigan
Lergigan
Lilly 01516
Lilly 1516
Lopac0_000899
Metaryl
MolPort-001-783-684
N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine
N,N,α-trimethyl-10H-phenothiazine-10-ethanamine
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
 
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride
N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine
N-(2'-dimethylamino-2'-Methyl)ethylphenothiazine
N-Dimethylamino-2-methylethyl thiodiphenylamine
NCGC00015817-10
NCGC00089735-02
NCGC00089735-03
NCI-C60673
NCI60_001878
NINDS_000005
NSC 30321
NSC30321
Oprea1_758749
PROMETHAZINE (SEE ALSO PROMETHAZINE HYDROCHLORIDE 58-33-3)
Pelpica
Phargan
Phenargan
Phenerzine
Phenoject-50
Phensedyl
Pilothia
Pilpophen
Pipolphene
Prestwick0_000888
Prestwick1_000888
Prestwick2_000888
Prestwick3_000888
Pro-50
Proazaimine
Proazamine
Procit
Promacot
Promazinamide
Promergan
Promesan
Prometasin
Prometazin
Prometazina
Prometazina [INN-Spanish]
Prometazine
Prometh
Promethacon
Promethaine
Promethazin
Promethazine
Promethazine (JAN/INN)
Promethazine [INN:BAN]
PromethazineHcl
Promethazinum
Promethazinum [INN-Latin]
Promethegan
Promethiazine
Promezathine
Prorex
Protazine
Prothazin
Prothazine
Provigan
Pyrethia
Pyrethiazine
RP 3277
Remsed
Romergan
Rumergan
SKF 1498
SPBio_000799
SPBio_002895
Spectrum2_000840
Spectrum3_001019
Spectrum4_001149
Spectrum5_000977
Spectrum_000868
Tanidil
Thiergan
UNII-FF28EJQ494
Valergine
Vallergine
WLN: T C666 BN ISJ B1Y1&N1&1
WY 509
Zipan-25
promethazine
3
HistamineapprovedPhase 4103475614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
4
DiphenhydramineapprovedPhase 422558-73-1, 147-24-03100
Synonyms:
147-24-0
147-24-0 (HYDROCHLORIDE)
2-(Benzhydryloxy)-N,N-dimethylethylamine
2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride
2-(Diphenylmethoxy)-N,N-dimethylethylamine
2-(diphenylmethoxy)-N,N-dimethylethanamine
2-Diphenylmethoxy-N,N-dimethylethylamine
2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine
2-benzhydryloxy-N,N-dimethylethanamine
2-benzhydryloxyethyl-N,N-dimethylammonium
2-diphenylmethoxy-N,N-demthylethanamine
2PM
58-73-1
88637-37-0 (citrate (1:1))
AB00053460
AC-13704
AC1L1F65
AKOS003658554
Aleryl
Alledryl
Aller-Med
Allerdryl
Allergan
Allergan B
Allergeval
Allergical
Allergina
Allergival
Allermax Caplets
Amidryl
Antistominum
Antitussive
Antomin
Automin
BENADRYL HCl
BIDD:GT0152
BPBio1_000275
BRD-K47278471-003-05-7
BRN 1914136
BSPBio_000249
BSPBio_002219
Bagodryl
Banophen
Banophen Caplets
Baramine
Beldin
Belix
Ben-allergin
Bena
Benachlor
Benadrin
Benadryl
Benadryl (hydrochloride)
Benadryl Allergy
Benapon
Bendylate
Benhydramin
Benodin
Benodine
Benylan
Benylin
Benzantin
Benzantine
Benzhydramine
Benzhydraminum
Benzhydril
Benzhydroamina
Benzhydryl
Betramin
CAS-147-24-0
CCRIS 1959
CHEBI:127629
CHEBI:4636
CHEMBL657
CID3100
CPD-10890
Compoz
D00300
DB01075
DB06975
DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE
Dabylen
Debendrin
Dermistina
Dermodrin
Desentol
Diabenyl
Diabylen
Dibendrin
Dibenil
Dibondrin
Difedryl
Difenhidramina
Difenhidramina [INN-Spanish]
Difenhydramin
Difenhydramine
Difenidramina
Difenidramina [Italian]
Dihidral
Dimedrol
Dimedrol base
Dimedrolum
Dimedryl
Dimehydrinate
Dimethylamine benzhydryl ester
Diphamine
Diphantine
Diphen
 
Diphen Cough
Diphenhist
Diphenhist Captabs
Diphenhydramine
Diphenhydramine (JP15/INN)
Diphenhydramine Base
Diphenhydramine HCl
Diphenhydramine [INN:BAN:JAN]
Diphenhydraminum
Diphenhydraminum [INN-Latin]
Diphenylhydramin
Diphenylhydramine
DivK1c_000368
Dobacen
Dormarex 2
Dryistan
Drylistan
Dylamon
EINECS 200-396-7
Etanautine
FAR 90X2
Genahist
HMS2089E06
HSDB 3066
Histaxin
Hyadrine
Hydramine
Hyrexin
I14-6749
IDI1_000368
Ibiodral
KBio1_000368
KBio2_001460
KBio2_004028
KBio2_006596
KBio3_001439
KBioGR_001099
KBioSS_001460
L000227
LS-68208
Lopac-D-3630
Lopac0_000377
MLS002222276
Medidryl
Mephadryl
MolPort-001-783-508
N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride
N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine
N-(Benzhydryloksy-etylo)dwumetyloamina
N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]
N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE
NCGC00015335-01
NCGC00015335-02
NCGC00015335-03
NCGC00015335-10
NCGC00024414-03
NCGC00024414-04
NCI60_002916
NCI60_022782
NINDS_000368
NSC665800
Nausen
Nervine Nighttime Sleep-Aid
Novamina
Nytol Quickcaps
Nytol Quickgels
O-Benzhydryldimethylaminoethanol
O-benzhydryldimethylaminoethanol
Oprea1_254625
PM 255
Prestwick0_000065
Prestwick1_000065
Prestwick2_000065
Prestwick3_000065
Probedryl
Restamin
Restamin (TN)
Rigidil
S51
SMR001307259
SPBio_000961
SPBio_002170
STK103720
STOCK2S-94461
Siladryl
Silphen
Sleep-Eze D
Sleep-Eze D Extra Strength
Spectrum2_000961
Spectrum3_000400
Spectrum4_000520
Spectrum5_000915
Spectrum_000980
Syntedril
Syntodril
TL8003758
Twilite Caplets
UNII-8GTS82S83M
Unisom Sleepgels Maximum Strength
alpha-(2-Dimethylaminoethoxy)diphenylmethane
beta-Dimethylamino-aethyl-benzhydryl-aether
beta-Dimethylamino-aethyl-benzhydryl-aether [German]
beta-Dimethylaminoethanol diphenylmethyl ether
beta-Dimethylaminoethyl benzhydryl ether
beta-Dimethylaminoethylbenzhydrylether
beta-dimethylaminoethyl benzhydryl ether
diphenhydramine
nchembio747-comp18
β-dimethylaminoethyl benzhydryl ether
5Anti-Allergic AgentsPhase 41490
6Histamine H1 AntagonistsPhase 4782
7Hypnotics and SedativesPhase 42485
8Neurotransmitter AgentsPhase 417734
9Anesthetics, LocalPhase 43272
10Peripheral Nervous System AgentsPhase 422776
11Histamine AntagonistsPhase 4946
12AntiemeticsPhase 43888
13Central Nervous System DepressantsPhase 412806
14Autonomic AgentsPhase 49774
15Dermatologic AgentsPhase 45674
16AnestheticsPhase 49001
17Gastrointestinal AgentsPhase 48109
18AntipruriticsPhase 4864

Interventional clinical trials:

idNameStatusNCT IDPhase
1Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity LevelsCompletedNCT02136420Phase 4
2Prospective Study for Safety and Efficacy of InSpace™ in Rotator Cuff Tear SubjectsCompletedNCT00916994
3Effects of Inverted Vision on Pointing and Grasping in Parabolic FlightRecruitingNCT02885844
4Influence of Gravity on the Perception of Egocentric Distance (Blindpulling)RecruitingNCT02508545
5Parabolic Flight Induced Neuroplasticity Studied With Advanced Magnetic Resonance Imaging MethodsRecruitingNCT02517216

Search NIH Clinical Center for Space Motion Sickness


Cochrane evidence based reviews: space motion sickness

Genetic Tests for Space Motion Sickness

About this section

Anatomical Context for Space Motion Sickness

About this section

MalaCards organs/tissues related to Space Motion Sickness:

35
Testes, Eye, Hypothalamus, Brain

Animal Models for Space Motion Sickness or affiliated genes

About this section

Publications for Space Motion Sickness

About this section

Articles related to Space Motion Sickness:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Space motion sickness and motion sickness: symptoms and etiology. (23855067)
2013
2
A rationale for space motion sickness. (21485406)
2011
3
A re-investigation of the role of utricular asymmetries in Space Motion Sickness. (21558639)
2011
4
A rationale for space motion sickness. (21748915)
2011
5
Space motion sickness: incidence, etiology, and countermeasures. (16935570)
2006
6
Space motion sickness. (17021896)
2006
7
Preflight virtual reality training as a countermeasure for space motion sickness and disorientation. (15828634)
2005
8
Effects of drug countermeasures for space motion sickness on working memory in humans. (15451046)
2004
9
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. (15354005)
2004
10
Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness. (12528715)
2002
11
Squirrel monkeys and space motion sickness. (12047798)
2002
12
Relationship between selected orientation rest frame, circular vection and space motion sickness. (10052580)
1998
13
Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness. (9177562)
1997
14
Space motion sickness. (7741942)
1995
15
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. (11537946)
1994
16
Comparison of treatment strategies for Space Motion Sickness. (11541638)
1993
17
Psychophysiological aspects of increasing resistance to space motion sickness. (11538510)
1993
18
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. (1546939)
1992
19
Ocular torsion as a test of the asymmetry hypothesis of space motion sickness. (11537575)
1992
20
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. (1599177)
1992
21
Electrical vestibular stimulation and space motion sickness. (11540742)
1992
22
New pharmacologic approaches to the prevention of space/motion sickness. (1662231)
1991
23
Altered sensorimotor control of the body as an etiological factor in space motion sickness. (1930058)
1991
24
Prediction of space motion sickness susceptibility by disconjugate eye torsion in parabolic flight. (2012564)
1991
25
Space motion sickness. (2197405)
1990
26
Instability of ocular torsion in zero gravity: possible implications for space motion sickness. (2241730)
1990
27
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. (2748293)
1989
28
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. (11537411)
1989
29
Space motion sickness during 24 flights of the space shuttle. (3240221)
1988
30
Neurohumoral mechanism of space motion sickness. (11542422)
1988
31
Comparison of aerobic fitness and space motion sickness during the shuttle program. (3390102)
1988
32
Space motion sickness preflight adaptation training: preliminary studies with prototype trainers. (11539742)
1987
33
Mechanisms of selective attention and space motion sickness. (3689281)
1987
34
The use of the logistic model in space motion sickness prediction. (3675512)
1987
35
Head movements in low and high gravitoinertial force environments elicit motion sickness: implications for space motion sickness. (3675494)
1987
36
The vestibulo-ocular reflex and its possible roles in space motion sickness. (3675486)
1987
37
Possible role of brain stem respiratory neurons in mediating vomiting during space motion sickness. (2960318)
1987
38
Clinical characterization and etiology of space motion sickness. (3499891)
1987
39
The effective intensity of Coriolis, cross-coupling stimulation is gravitoinertial force dependent: implications for space motion sickness. (3485968)
1986
40
Head movements in non-terrestrial force environments elicit motion sickness: implications for the etiology of space motion sickness. (3707473)
1986
41
Sudden emesis following parabolic flight maneuvers: implications for space motion sickness. (3485969)
1986
42
M.I.T./Canadian vestibular experiments on the Spacelab-1 mission: 4. Space motion sickness: symptoms, stimuli, and predictability. (3803476)
1986
43
Space motion sickness and space vestibulology. (3874411)
1985
44
Psychology of spaceflight: II. Suggested bases of space motion sickness: perceptual disorientation and elevated stomach pH. (3982930)
1985
45
Carbonic anhydrase inhibitors for prevention of space motion sickness: an avenue of investigation. (6517821)
1984
46
Etiological factors in space motion sickness. (6605145)
1983
47
Sensory conflict theory of space motion sickness: an anatomical location for the neuroconflict. (6870740)
1983
48
Coping with space motion sickness in Spacelab missions. (11543090)
1981
49
Variations in gravitoinertial force level affect the gain of the vestibulo-ocular reflex: implications for the etiology of space motion sickness. (6971638)
1981
50
Space motion sickness. (11902170)
1979

Variations for Space Motion Sickness

About this section

Expression for genes affiliated with Space Motion Sickness

About this section
Search GEO for disease gene expression data for Space Motion Sickness.

Pathways for genes affiliated with Space Motion Sickness

About this section

Pathways related to Space Motion Sickness according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1AVP, SCT

GO Terms for genes affiliated with Space Motion Sickness

About this section

Cellular components related to Space Motion Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7AVP, CHIT1, SCT
2extracellular regionGO:00055767.9AVP, CHIT1, NTS, SCT

Biological processes related to Space Motion Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP biosynthetic processGO:00308199.1AVP, SCT
2carbohydrate metabolic processGO:00059759.1CHIT1, FUT2

Molecular functions related to Space Motion Sickness according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.4AVP, NTS

Sources for Space Motion Sickness

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet