MCID: SPS003
MIFTS: 34

Spastic Diplegia malady

Rare diseases, Neuronal diseases, Mental diseases categories

Summaries for Spastic Diplegia

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Disease Ontology:9 A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. the legs cross at the knees, making it difficult to walk.

MalaCards based summary: Spastic Diplegia, also known as diplegic infantile cerebral palsy, is related to microcephaly and mental retardation. An important gene associated with Spastic Diplegia is TNFSF8 (tumor necrosis factor (ligand) superfamily, member 8), and among its related pathways are Valine, leucine and isoleucine degradation and Tryptophan metabolism. The compounds nad+ and nad have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex.

Wikipedia:63 Spastic diplegia, historically known as Little\'s Disease, is a form of cerebral palsy (CP) that is a... more...

Aliases & Classifications for Spastic Diplegia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Spastic Diplegia, Aliases & Descriptions:

Name: Spastic Diplegia 9 11 43
Diplegic Infantile Cerebral Palsy 9 60
Little's Disease 9 60
Cerebral Spastic Infantile Paralysis 9
 
Infantile Diplegic Cerebral Palsy 9
Infantile Spastic Cerebral Palsy 9
Littles Disease 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Mental diseases


External Ids:

Disease Ontology9 DOID:10965
NCIt38 C34781
MeSH33 D002547

Related Diseases for Spastic Diplegia

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Diseases in the Spastic Diplegia family:

Spastic Diplegia Infantile Type

Diseases related to Spastic Diplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1microcephaly29.9RAB3GAP1, ATRX
2mental retardation29.5ATRX, L1CAM, HSD17B10, ALDH3A2
3spasticity11.2
4cerebritis10.7
5cerebral palsy10.7
6spastic diplegia cerebral palsy10.6
7spastic diplegia infantile type10.5
8periventricular leukomalacia10.4
9leukomalacia10.4
10spastic hemiplegia10.3
11hemiplegia10.3
12severe intellectual disability-progressive spastic diplegia syndrome10.3
13warburg micro syndrome 110.2
14argininemia10.2
15arthritis10.2
16hereditary spastic paraplegia10.2
17pain disorder10.2
18paraplegia10.2
19ataxia10.2
20cerebral palsy, spastic quadriplegic, 110.1
21mental retardation, autosomal dominant 1910.1
22microphthalmia, syndromic 310.1
23perrault syndrome 110.1
24saccharopinuria10.1
25angelman syndrome10.1
26microphthalmia, syndromic 110.1
27neuroblastoma10.1
28renpenning syndrome10.1
29intestinal pseudoobstruction, neuronal10.1
30cerebellar ataxia10.1
31immunodeficiency due to purine nucleoside phosphorylase deficiency10.1
32glutaricaciduria, type i10.1
33hemangioma10.1
34holoprosencephaly10.1
35hydrocephalus10.1
36renal tubular acidosis10.1
37blepharophimosis10.1
38quadriplegia10.1
39brain disease10.1
40mediastinitis10.1
41myopathy10.1
42ptosis10.1
43fetal iodine syndrome10.1
44hip subluxation10.1
45oculorenocerebellar syndrome10.1
46spastic paraparesis10.1
47vein of galen aneurysm10.1
48aneurysm10.1
49hypoxia10.1
50tremor10.1

Graphical network of the top 20 diseases related to Spastic Diplegia:



Diseases related to spastic diplegia

Symptoms for Spastic Diplegia

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Drugs & Therapeutics for Spastic Diplegia

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Drug clinical trials:

Search ClinicalTrials for Spastic Diplegia

Search NIH Clinical Center for Spastic Diplegia

Genetic Tests for Spastic Diplegia

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Anatomical Context for Spastic Diplegia

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MalaCards organs/tissues related to Spastic Diplegia:

31
Brain, Testes, Cortex

Animal Models for Spastic Diplegia or affiliated genes

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Publications for Spastic Diplegia

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Articles related to Spastic Diplegia:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. (23121133)
2013
2
Hip flexion deformity improves without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia. (22878968)
2012
3
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. (22200241)
2012
4
Rectus femoris distal tendon resection improves knee motion in patients with spastic diplegia. (21842297)
2012
5
Distal rectus femoris transfer as part of multilevel surgery in children with spastic diplegia--a randomized clinical trial. (22425637)
2012
6
Commentary on an article by Pamela Thomason, BPhty, MPT, et al.: "Single-event multilevel surgery in children with spastic diplegia. A pilot randomized controlled trial". (21368072)
2011
7
Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia. (21385750)
2011
8
Extraarticular subtalar arthrodesis for pes planovalgus: an interim result of 50 feet in patients with spastic diplegia. (20190996)
2010
9
Changes in lower limb rotation after soft tissue surgery in spastic diplegia. (20175660)
2010
10
Incidence of spinal abnormalities in patients with spastic diplegia 17 to 26 years after selective dorsal rhizotomy. (19784657)
2009
11
The outcome of intrathecal baclofen treatment on spastic diplegia: Preliminary results with a minimum of two year follow-up. (21791773)
2008
12
Reach performance and postural adjustments during standing in children with severe spastic diplegia using dynamic ankle-foot orthoses. (17999010)
2007
13
Are patients with hereditary spastic paraplegia different from patients with spastic diplegia during walking? Gait evaluation using 3D gait analysis. (17509240)
2007
14
Muscle contractile properties in children with spastic diplegia. (17418991)
2007
15
A clinical and etiologic profile of spastic diplegia. (16504791)
2006
16
Kinematic and kinetic evaluation of the ankle joint before and after tendo achilles lengthening in patients with spastic diplegia. (15958899)
2005
17
Conversion of biarticular to monoarticular muscles as a component of multilevel surgery in spastic diplegia. (14765875)
2004
18
A 2-year follow-up of outcomes following orthopedic surgery or selective dorsal rhizotomy in children with spastic diplegia. (15599225)
2004
19
Treatment of spastic diplegia in patients with cerebral palsy. (15076595)
2004
20
Wartenberg pendulum test: objective quantification of muscle tone in children with spastic diplegia undergoing selective dorsal rhizotomy. (11811646)
2002
21
Multilevel surgery in spastic diplegia: evaluation by physical examination and gait analysis in 25 children. (11856920)
2002
22
Architecture of the medial gastrocnemius in children with spastic diplegia. (12005316)
2002
23
Syntelencephaly presenting with spastic diplegia. (11071147)
2000
24
Developmental sequence of postural control in prone position in children with spastic diplegia. (11102729)
2000
25
Construct validity of the In-Hand Manipulation Test: a discriminant analysis with children without disability and children with spastic diplegia. (10427678)
1999
26
Influence of infant-walkers on motor development: mimicking spastic diplegia? (10595672)
1999
27
Increased risk of spastic diplegia among very low birth weight children after preterm labor or prelabor rupture of membranes. (9544916)
1998
28
Ankle-foot orthoses for preambulatory children with spastic diplegia. (9150028)
1997
29
Daily physical activity of schoolchildren with spastic diplegia and of healthy control subjects. (7562279)
1995
30
Effects of quadriceps femoris muscle strengthening on crouch gait in children with spastic diplegia. (7644570)
1995
31
The cognitive development of children born preterm and affected by spastic diplegia. (8147501)
1993
32
The lumbar spine in spastic diplegia. A radiographic study. (8331105)
1993
33
Visuo-perceptual impairment and cerebral lesions in spastic diplegia with preterm birth. (1443403)
1992
34
Surgical management of spastic diplegia. (1445590)
1992
35
Leg movements in the supine position of infants with spastic diplegia. (1743414)
1991
36
MR imaging of spastic diplegia. Comparative study between preterm and term infants. (2215901)
1990
37
Gross motor patterns in children with cerebral palsy and spastic diplegia. (2206157)
1990
38
Hereditary spastic diplegia with mental retardation in two young siblings. (2591069)
1989
39
Physical therapy for infants with spastic diplegia. (2920867)
1989
40
Effects of ankle-foot orthoses on functional motor performance in a child with spastic diplegia. (3740202)
1986
41
Pre- and postoperative gait analysis in patients with spastic diplegia: a preliminary report. (6511900)
1984
42
Hemorrhagic periventricular leukomalacia and spastic diplegia. (6701071)
1984
43
Spastic diplegia among children of low and normal birthweight. (6653904)
1983
44
Very low birthweight and subsequent neurological defect (with special reference to spastic diplegia). (1123121)
1975
45
Spastic diplegia after short gestation. (5463200)
1970
46
Spastic diplegia following mediastinal neuroblastoma. A case report. (5512975)
1970
47
The prehensile grasp of spastic diplegia. (13957620)
1963
48
WEIGHT LOSS IN PREMATURE INFANTS DEVELOPING SPASTIC DIPLEGIA. (14082279)
1963
49
Spastic Diplegia with Mental Defect. (19974783)
1910
50
A Case of Infantile Spastic Diplegia, with Tremors of the "Disseminated Sclerosis" Type. (20753356)
1891

Variations for Spastic Diplegia

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Expression for genes affiliated with Spastic Diplegia

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Search GEO for disease gene expression data for Spastic Diplegia.

Pathways for genes affiliated with Spastic Diplegia

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Pathways related to Spastic Diplegia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I36
valine degradation I36
pyruvate fermentation to lactate36
isoleucine degradation I36
9.6ALDH3A2, HSD17B10
2
Show member pathways
9.6ALDH3A2, HSD17B10
3
Show member pathways
Alzheimers Disease36
9.5NDUFV1, HSD17B10

Compounds for genes affiliated with Spastic Diplegia

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Sources:
43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Spastic Diplegia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1nad+439.6ALDH3A2, HSD17B10
2nad28 2410.0NDUFV1, ALDH3A2, HSD17B10
3nadh43 24 1210.8NDUFV1, ALDH3A2, HSD17B10

GO Terms for genes affiliated with Spastic Diplegia

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Cellular components related to Spastic Diplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:00057439.1NDUFV1, ALDH3A2, HSD17B10

Products for genes affiliated with Spastic Diplegia

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Sources for Spastic Diplegia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet