MCID: SPS003
MIFTS: 36

Spastic Diplegia malady

Summaries for Spastic Diplegia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. the legs cross at the knees, making it difficult to walk.

MalaCards: Spastic Diplegia, also known as diplegic infantile cerebral palsy, is related to quadriplegia and microcephaly. An important gene associated with Spastic Diplegia is ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), and among its related pathways are Branched-chain amino acid catabolism and Tryptophan metabolism. The compounds nadh and nad have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex.

Wikipedia:63 Spastic diplegia, historically known as Little\'s Disease, is a form of cerebral palsy (CP) that is a... more...

Aliases & Classifications for Spastic Diplegia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

spastic diplegia 8 10 44
diplegic infantile cerebral palsy 8 60
little's disease 8 60
cerebral spastic infantile paralysis 8
infantile diplegic cerebral palsy 8
infantile spastic cerebral palsy 8
littles disease 8


External Ids:

Disease Ontology8 DOID:10965
NCIt39 C34781
MeSH34 D002547

Related Diseases for Spastic Diplegia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spastic Diplegia:



Diseases related to spastic diplegia

Clinical Features for Spastic Diplegia

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Drugs & Therapeutics for Spastic Diplegia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spastic Diplegia

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Anatomical Context for Spastic Diplegia

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32MalaCards
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MalaCards organs/tissues related to Spastic Diplegia:

32
Brain, Testes, Cortex

Animal Models for Spastic Diplegia or affiliated genes

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Publications for Spastic Diplegia

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50PubMed
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Articles related to Spastic Diplegia:

(show top 50)    (show all 186)
idTitleAuthorsYear
1
Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. (23121133)
2013
2
Effects of vojta therapy on gait of children with spastic diplegia. (24409030)
2013
3
Reliability of head and trunk kinematics during gait in children with spastic diplegia. (23062729)
2013
4
Rectus femoris distal tendon resection improves knee motion in patients with spastic diplegia. (21842297)
2012
5
Kinematic and electromyographic studies on unaided, unilateral and bilateral crutch walking in adolescents with spastic diplegia. (22130909)
2012
6
Level of activity and participation in adults with spastic diplegia 17-26 years after selective dorsal rhizotomy. (21327322)
2011
7
The effect of physiotherapy on sit-to-stand movements in a child with spastic diplegia. (19852706)
2010
8
Incidence of spinal abnormalities in patients with spastic diplegia 17 to 26 years after selective dorsal rhizotomy. (19784657)
2009
9
Reach performance and postural adjustments during standing in children with severe spastic diplegia using dynamic ankle-foot orthoses. (17999010)
2007
10
Are patients with hereditary spastic paraplegia different from patients with spastic diplegia during walking? Gait evaluation using 3D gait analysis. (17509240)
2007
11
Muscle contractile properties in children with spastic diplegia. (17418991)
2007
12
Postoperative gait velocity and mean knee flexion in stance of ambulatory children with spastic diplegia four years or more after multilevel surgery. (17513969)
2007
13
Physical therapy clinical management recommendations for children with cerebral palsy - spastic diplegia: achieving functional mobility outcomes. (16508534)
2006
14
How do we treat pediatric patients with spastic diplegia? (17108805)
2006
15
Kinematic and kinetic evaluation of the ankle joint before and after tendo achilles lengthening in patients with spastic diplegia. (15958899)
2005
16
Orthopedic surgery after selective dorsal rhizotomy for spastic diplegia in relation to ambulatory status and age. (16121998)
2005
17
Conversion of biarticular to monoarticular muscles as a component of multilevel surgery in spastic diplegia. (14765875)
2004
18
Spastic diplegia and other motor disturbances in infants receiving interferon-alpha. (15235352)
2004
19
Sagittal gait patterns in spastic diplegia. (15046442)
2004
20
Dynamic ankle-foot orthoses as a part of treatment in children with spastic diplegia--parents' perceptions. (12879728)
2003
21
Reliability and validity of the Observational Gait Scale in children with spastic diplegia. (12549749)
2003
22
Lipid myopathy associated with renal tubular acidosis and spastic diplegia in two brothers. (11579615)
2001
23
Architecture of the medial gastrocnemius in children with spastic diplegia. (11769264)
2001
24
Reading of kana (phonetic symbols for syllables) in Japanese children with spastic diplegia and periventricular leukomalacia. (10761828)
2000
25
Quantification of antagonist muscle coactivation in children with spastic diplegia. (9725575)
1998
26
Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy. (9544915)
1998
27
Comparison of functional outcomes from orthopedic and neurosurgical interventions in spastic diplegia. (17206773)
1998
28
Developmental skills of children with spastic diplegia: functional and qualitative changes after selective dorsal rhizotomy. (9305266)
1997
29
The lumbar spine in spastic diplegia. A radiographic study. (8331105)
1993
30
Simultaneous multiple operations for spastic diplegia. Outcome and functional assessment of walking in 18 patients. (8496229)
1993
31
Gait parameters of children with spastic diplegia: a comparison of effects of posterior and anterior walkers. (8466419)
1993
32
Visuo-perceptual impairment and cerebral lesions in spastic diplegia with preterm birth. (1443403)
1992
33
Surgical management of spastic diplegia. (1445590)
1992
34
Surgical management of spastic diplegia in cerebral palsy. (1738380)
1992
35
Physical therapeutic and surgical management in spastic diplegia. A Japanese experience. (2317989)
1990
36
Heterogeneity of X-linked recessive (spino)cerebellar ataxia with or without spastic diplegia. (2816991)
1989
37
Physical therapy in spastic diplegia. (2899669)
1988
38
Decreasing gestational age and birthweight in spastic diplegia. (3228965)
1988
39
Physical therapy in spastic diplegia. (2900395)
1988
40
Cerebral palsy: postural-locomotor prognosis in spastic diplegia. (4038028)
1985
41
Pre- and postoperative gait analysis in patients with spastic diplegia: a preliminary report. (6511900)
1984
42
High risk factors for spastic diplegia and hemiplegia. (6707424)
1984
43
Spastic diplegia and the significance of mothers' previous reproductive loss. (7106400)
1982
44
Spastic diplegia in premature infants. Etiologic and diagnostic considerations. (7270517)
1981
45
Management of spastic diplegia by the physiatrist. (5059475)
1972
46
Spastic diplegia following mediastinal neuroblastoma. A case report. (5512975)
1970
47
A new objective method for evaluating muscle relaxants in congenital spastic diplegia. (5922055)
1966
48
WEIGHT LOSS IN PREMATURE INFANTS DEVELOPING SPASTIC DIPLEGIA. (14082279)
1963
49
Congenital Ichthyosis, Spastic Diplegia, and Mental Deficiency. (20788940)
1960
50
Convulsive disorder with spastic diplegia and mental deterioration. (14774738)
1950

Genetic Variations for Spastic Diplegia

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Expression for genes affiliated with Spastic Diplegia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spastic Diplegia

Search GEO for disease gene expression data for Spastic Diplegia.

Pathways for genes affiliated with Spastic Diplegia

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Spastic Diplegia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9ALDH3A2, HSD17B10
2
Hide members
9.9ALDH3A2, HSD17B10
3
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9.9ALDH3A2, ARG1

Compounds for genes affiliated with Spastic Diplegia

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Spastic Diplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nadh44 11 2411.5ALDH3A2, NDUFV1, HSD17B10
2nad28 2410.2ALDH3A2, NDUFV1, HSD17B10

GO Terms for genes affiliated with Spastic Diplegia

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16Gene Ontology
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Biological processes related to Spastic Diplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of GTPase activityGO:0430879.0RAB3GAP2, RAB3GAP1

Products for genes affiliated with Spastic Diplegia

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Sources for Spastic Diplegia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet