MCID: SPS003
MIFTS: 36

Spastic Diplegia malady

Summaries for Spastic Diplegia

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. the legs cross at the knees, making it difficult to walk.

MalaCards: Spastic Diplegia, also known as diplegic infantile cerebral palsy, is related to quadriplegia and microcephaly. An important gene associated with Spastic Diplegia is ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), and among its related pathways are Branched-chain amino acid catabolism and Tryptophan metabolism. The compounds nadh and nad have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex.

Wikipedia:63 Spastic diplegia, historically known as Little\'s Disease, is a form of cerebral palsy (CP) that is a... more...

Aliases & Classifications for Spastic Diplegia

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

spastic diplegia 8 10 44
diplegic infantile cerebral palsy 8 60
little's disease 8 60
cerebral spastic infantile paralysis 8
infantile diplegic cerebral palsy 8
infantile spastic cerebral palsy 8
littles disease 8


External Ids:

Disease Ontology8 DOID:10965
NCIt39 C34781
MeSH34 D002547

Related Diseases for Spastic Diplegia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Spastic Diplegia:



Diseases related to spastic diplegia

Clinical Features for Spastic Diplegia

About this section

Drugs & Therapeutics for Spastic Diplegia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spastic Diplegia

Drug clinical trials:

Search ClinicalTrials for Spastic Diplegia

Search NIH Clinical Center for Spastic Diplegia

Search CenterWatch for Spastic Diplegia

Genetic Tests for Spastic Diplegia

About this section

Anatomical Context for Spastic Diplegia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Spastic Diplegia:

32
Brain, Testes, Cortex

Animal Models for Spastic Diplegia or affiliated genes

About this section

Publications for Spastic Diplegia

About this section
Sources:
50PubMed
See all sources

Articles related to Spastic Diplegia:

(show top 50)    (show all 186)
idTitleAuthorsYear
1
Blepharophimosis-ptosis-epicanthus inversus syndrome plus: deletion 3q22.3q23 in a patient with characteristic facial features and with genital anomalies, spastic diplegia, and speech delay. (21934608)
2012
2
Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia. (21385750)
2011
3
Comparison of 3 different methods to analyze ankle plantarflexor stiffness in children with spastic diplegia cerebral palsy. (22133254)
2011
4
Extraarticular subtalar arthrodesis for pes planovalgus: an interim result of 50 feet in patients with spastic diplegia. (20190996)
2010
5
Changes in lower limb rotation after soft tissue surgery in spastic diplegia. (20175660)
2010
6
MR and Diffusion Tensor Imaging of Vein of Galen Aneurysmal Malformation in an Infant Presenting with Spastic Diplegia and Seizures. A Case Report. (24148343)
2010
7
Functional connectivity for somatosensory and motor cortex in spastic diplegia. (20047510)
2009
8
The outcome of intrathecal baclofen treatment on spastic diplegia: Preliminary results with a minimum of two year follow-up. (21791773)
2008
9
Altered cortical inhibitory function in children with spastic diplegia: a TMS study. (18214452)
2008
10
Effects of massage on the mechanical behaviour of muscles in adolescents with spastic diplegia: a pilot study. (17355474)
2007
11
Exploring physical therapy clinical decision making for children with spastic diplegia: survey of pediatric practice. (16357657)
2005
12
Range of motion in children with spastic diplegia, GMFCS I-II compared to age and gender matched controls. (16120556)
2005
13
The reliability and validity of assessment of sagittal plane deviations in children who have spastic diplegia. (16344032)
2005
14
Motor outcome differences between two groups of children with spastic diplegia who received different intensities of early onset physiotherapy followed for 5 years. (15036431)
2004
15
Comparison of three ankle-foot orthosis configurations for children with spastic diplegia. (15344518)
2004
16
Spastic diplegia and periventricular white matter abnormalities in 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency, a defect of isoleucine metabolism: differential diagnosis with hypoxic-ischemic brain diseases. (15059617)
2004
17
Femoral derotation osteotomy in spastic diplegia. Proximal or distal? (12678365)
2003
18
Botulinum toxin with and without casting in ambulant children with spastic diplegia: a clinical and functional assessment. (14580131)
2003
19
Objective measurement of muscle strength in children with spastic diplegia after selective dorsal rhizotomy. (11932845)
2002
20
Motor strategies in standing up in leukomalacic spastic diplegia. (12142066)
2002
21
Motor functions in non-ambulatory children with spastic diplegia and periventricular leukomalacia. (11504605)
2001
22
Developmental sequence of postural control in prone position in children with spastic diplegia. (11102729)
2000
23
Head stability during whole body movements in spastic diplegia. (10722960)
2000
24
Construct validity of the In-Hand Manipulation Test: a discriminant analysis with children without disability and children with spastic diplegia. (10427678)
1999
25
Interferon alpha-2a therapy in haemangiomas of infancy: spastic diplegia as a severe complication. (10206141)
1999
26
Ankle-foot orthoses for preambulatory children with spastic diplegia. (9150028)
1997
27
Assessment of upper-extremity function in children with spastic diplegia before and after selective dorsal rhizotomy. (8913178)
1996
28
Gait changes in children with spastic diplegia after selective dorsal rhizotomy. (8906646)
1996
29
Postural control in children with spastic diplegia: muscle activity during perturbations in sitting. (8698146)
1996
30
Daily physical activity of schoolchildren with spastic diplegia and of healthy control subjects. (7562279)
1995
31
Effects of selective dorsal rhizotomy for spastic diplegia on hip migration in cerebral palsy. (8142281)
1994
32
The cognitive development of children born preterm and affected by spastic diplegia. (8147501)
1993
33
Gross motor patterns in children with cerebral palsy and spastic diplegia. (2206157)
1990
34
Physical therapy for infants with spastic diplegia. (2920867)
1989
35
Calcaneal gait in spastic diplegia after heel cord lengthening: a study with gait analysis. (2600179)
1989
36
Computed tomographic findings in children with spastic diplegia: correlation with the severity of their motor abnormality. (2774092)
1989
37
Early diagnosis of spastic diplegia, spastic hemiplegia, and quadriplegia. (2816867)
1989
38
Cerebral palsy in low-birthweight infants. II. Spastic diplegia: associations with fetal immaturity. (3371567)
1988
39
Linkage studies with the gene for an X-linked syndrome of mental retardation, microcephaly and spastic diplegia (MRX2) (3177467)
1988
40
One-session surgery for bilateral correction of lower limb deformities in spastic diplegia. (3584439)
1987
41
Effects of ankle-foot orthoses on functional motor performance in a child with spastic diplegia. (3740202)
1986
42
Hemorrhagic periventricular leukomalacia and spastic diplegia. (6701071)
1984
43
Early physiotherapy in the treatment of spastic diplegia. (6479463)
1984
44
Severe pes valgus in spastic diplegia. A case report. (6841883)
1983
45
Very low birthweight and subsequent neurological defect (with special reference to spastic diplegia). (1123121)
1975
46
Behr's syndrome: familial optic atrophy, spastic diplegia and ataxia. (4354046)
1973
47
Spastic diplegia of premature birth. (13810227)
1959
48
Case for Diagnosis; Multiple Arthritis (? Type) andA ? Spastic Diplegia. (20909028)
1925
49
Spastic Diplegia. (19978261)
1914
50
Spastic Diplegia with Mental Defect. (19974783)
1910

Genetic Variations for Spastic Diplegia

About this section

Expression for genes affiliated with Spastic Diplegia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spastic Diplegia

Search GEO for disease gene expression data for Spastic Diplegia.

Pathways for genes affiliated with Spastic Diplegia

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
See all sources

Pathways related to Spastic Diplegia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9ALDH3A2, HSD17B10
2
Hide members
9.9ALDH3A2, HSD17B10
3
Hide members
9.9ALDH3A2, ARG1

Compounds for genes affiliated with Spastic Diplegia

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Spastic Diplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nadh44 11 2411.5ALDH3A2, NDUFV1, HSD17B10
2nad28 2410.2ALDH3A2, NDUFV1, HSD17B10

GO Terms for genes affiliated with Spastic Diplegia

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Spastic Diplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of GTPase activityGO:0430879.0RAB3GAP2, RAB3GAP1

Products for genes affiliated with Spastic Diplegia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spastic Diplegia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet