MCID: SPS003
MIFTS: 36

Spastic Diplegia malady

Summaries for Spastic Diplegia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. the legs cross at the knees, making it difficult to walk.

MalaCards: Spastic Diplegia, also known as diplegic infantile cerebral palsy, is related to mental retardation and quadriplegia. An important gene associated with Spastic Diplegia is ALDH3A2 (aldehyde dehydrogenase 3 family, member A2), and among its related pathways are Branched-chain amino acid catabolism and Tryptophan metabolism. The compounds nadh and nad have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cortex.

Wikipedia:64 Spastic diplegia, historically known as Little\'s Disease, is a form of cerebral palsy (CP) that is a... more...

Aliases & Classifications for Spastic Diplegia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

spastic diplegia 8 10 45
diplegic infantile cerebral palsy 8 61
little's disease 8 61
cerebral spastic infantile paralysis 8
infantile diplegic cerebral palsy 8
infantile spastic cerebral palsy 8
littles disease 8


External Ids:

Disease Ontology8 DOID:10965
NCIt40 C34781
MeSH35 D002547

Related Diseases for Spastic Diplegia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spastic Diplegia:



Diseases related to spastic diplegia

Clinical Features for Spastic Diplegia

Drugs & Therapeutics for Spastic Diplegia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Spastic Diplegia

Drug clinical trials:

Search ClinicalTrials for Spastic Diplegia

Search NIH Clinical Center for Spastic Diplegia

Search CenterWatch for Spastic Diplegia

Genetic Tests for Spastic Diplegia

Anatomical Context for Spastic Diplegia

Sources:
33MalaCards
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MalaCards organs/tissues related to Spastic Diplegia:

33
Spinal cord, Brain, Cortex, Fetal brain

Animal Models for Spastic Diplegia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Spastic Diplegia

Sources:
51PubMed
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Articles related to Spastic Diplegia:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. (23121133)
2013
2
Day vs. day-night use of ankle-foot orthoses in young children with spastic diplegia: a randomized controlled study. (23739274)
2013
3
Long term outcome of single event multilevel surgery in spastic diplegia with flexed knee gait. (23041270)
2013
4
Spastic diplegia in children with HIV encephalopathy: first description of gait and physical status. (24182356)
2013
5
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. (22200241)
2012
6
Severe crouch gait in spastic diplegia can be prevented: a population-based study. (22161932)
2011
7
3D gait analysis in patients with hereditary spastic paraparesis and spastic diplegia: a kinematic, kinetic and EMG comparison. (20829081)
2011
8
Argininemia presenting with progressive spastic diplegia. (21310339)
2011
9
Immediate effects of therapeutic music on loaded sit-to-stand movement in children with spastic diplegia. (21185725)
2011
10
Reach performance and postural adjustments during standing in children with severe spastic diplegia using dynamic ankle-foot orthoses. (17999010)
2007
11
Muscle contractile properties in children with spastic diplegia. (17418991)
2007
12
Effectiveness of loaded sit-to-stand resistance exercise for children with mild spastic diplegia: a randomized clinical trial. (17207671)
2007
13
Relationships between spasticity, strength, gait, and the GMFM-66 in persons with spastic diplegia cerebral palsy. (17826455)
2007
14
A clinical and etiologic profile of spastic diplegia. (16504791)
2006
15
Proton magnetic resonance spectroscopy in children with spastic diplegia. (15157997)
2004
16
Comparison of the energy expenditure index and oxygen consumption index during self-paced walking in children with spastic diplegia cerebral palsy and children without physical disabilities. (17057550)
2004
17
Changes to medial gastrocnemius architecture after surgical intervention in spastic diplegia. (15473170)
2004
18
Intrarater reliability of lower limb sagittal range-of-motion measures in children with spastic diplegia. (12785440)
2003
19
Wartenberg pendulum test: objective quantification of muscle tone in children with spastic diplegia undergoing selective dorsal rhizotomy. (11811646)
2002
20
Architecture of the medial gastrocnemius in children with spastic diplegia. (12005316)
2002
21
Medial hamstring lengthening in the presence of hip flexor tightness in spastic diplegia. (12443954)
2002
22
Ankle and knee coupling in patients with spastic diplegia: effects of gastrocnemius-soleus lengthening. (12004014)
2002
23
Influence of two different sitting positions on postural adjustments in children with spastic diplegia. (11508919)
2001
24
Spastic diplegia is not associated with intrapartum hypoxia. (11234623)
2001
25
Classification of gait patterns in spastic hemiplegia and spastic diplegia: a basis for a management algorithm. (11851738)
2001
26
Syntelencephaly presenting with spastic diplegia. (11071147)
2000
27
Predictors of independent walking in children with spastic diplegia. (10805188)
2000
28
Spastic diplegia and interferon. (10064684)
1999
29
Quantification of antagonist muscle coactivation in children with spastic diplegia. (9725575)
1998
30
Gait assessment of fixed ankle-foot orthoses in children with spastic diplegia. (9473992)
1998
31
Genetic localisation of mental retardation with spastic diplegia to the pericentromeric region of the X chromosome: X inactivation in female carriers. (9598720)
1998
32
Orthotic management of gait in spastic diplegia. (9207708)
1997
33
Argininemia: a treatable genetic cause of progressive spastic diplegia simulating cerebral palsy: case reports and literature review. (9378897)
1997
34
Positron emission tomography in spastic diplegia. (7788969)
1995
35
A comparative magnetic resonance imaging study of the corpus callosum in neurologically normal children and children with spastic diplegia. (7841710)
1994
36
Surgical management of spastic diplegia. (1635578)
1992
37
Leg movements in the supine position of infants with spastic diplegia. (1743414)
1991
38
Magnetic resonance imaging in children with spastic diplegia: correlation with the severity of their motor and mental abnormality. (1704863)
1991
39
Lobar holoprosencephaly presenting as spastic diplegia. (3402680)
1988
40
Auditory biofeedback in spastic diplegia. (3712131)
1986
41
High risk factors for spastic diplegia and hemiplegia. (6707424)
1984
42
Spastic diplegia among children of low and normal birthweight. (6653904)
1983
43
The pathomechanics of progressive crouch gait in spastic diplegia. (347354)
1978
44
Spastic diplegia after short gestation. (5463200)
1970
45
Spastic diplegia following mediastinal neuroblastoma. A case report. (5512975)
1970
46
Familial spastic diplegia due to anoxic encephalopathy (Alpers). A contribution to the study of vascular fragilities of the nervous system of genetic type. (5878525)
1965
47
THE AETIOLOGY OF SPASTIC DIPLEGIA. A SYNTHESIS OF EPIDEMIOLOGICAL AND PATHOLOGICAL EVIDENCE. (14155187)
1964
48
The prehensile grasp of spastic diplegia. (13957620)
1963
49
WEIGHT LOSS IN PREMATURE INFANTS DEVELOPING SPASTIC DIPLEGIA. (14082279)
1963
50
Case of Spastic Diplegia with Congenital Morbus Cordis. (19985897)
1927

Genetic Variations for Spastic Diplegia

Expression for genes affiliated with Spastic Diplegia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spastic Diplegia

Search GEO for disease gene expression data for Spastic Diplegia.

Pathways for genes affiliated with Spastic Diplegia

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Spastic Diplegia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9ALDH3A2, HSD17B10
2
Hide members
9.9ALDH3A2, HSD17B10
3
Hide members
9.9ALDH3A2, ARG1

Compounds for genes affiliated with Spastic Diplegia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Spastic Diplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nadh45 11 2411.5ALDH3A2, NDUFV1, HSD17B10
2nad29 2410.2ALDH3A2, NDUFV1, HSD17B10

GO Terms for genes affiliated with Spastic Diplegia

Sources:
16Gene Ontology
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Biological processes related to Spastic Diplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of GTPase activityGO:0430879.0RAB3GAP2, RAB3GAP1

Products for genes affiliated with Spastic Diplegia

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Sources for Spastic Diplegia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet