MCID: SPS003
MIFTS: 37

Spastic Diplegia malady

Neuronal diseases category
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Summaries for Spastic Diplegia

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. the legs cross at the knees, making it difficult to walk.

MalaCards: Spastic Diplegia, also known as diplegic infantile cerebral palsy, is related to mental retardation and microcephaly. An important gene associated with Spastic Diplegia is TNFSF8 (tumor necrosis factor (ligand) superfamily, member 8), and among its related pathways are Valine, leucine and isoleucine degradation and Tryptophan metabolism. The compounds nad+ and nad have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex.

Wikipedia:65 Spastic diplegia, historically known as Little\'s Disease, is a form of cerebral palsy (CP) that is a... more...

Aliases & Classifications for Spastic Diplegia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spastic diplegia 8 10 45
diplegic infantile cerebral palsy 8 62
little's disease 8 62
cerebral spastic infantile paralysis 8
infantile diplegic cerebral palsy 8
infantile spastic cerebral palsy 8
littles disease 8


External Ids:

Disease Ontology8 DOID:10965
NCIt40 C34781
MeSH35 D002547

Related Diseases for Spastic Diplegia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spastic Diplegia:



Diseases related to spastic diplegia

Symptoms for Spastic Diplegia

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Drugs & Therapeutics for Spastic Diplegia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Spastic Diplegia

Search NIH Clinical Center for Spastic Diplegia

Genetic Tests for Spastic Diplegia

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Anatomical Context for Spastic Diplegia

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33MalaCards
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MalaCards organs/tissues related to Spastic Diplegia:

33
Brain, Testes, Cortex

Animal Models for Spastic Diplegia or affiliated genes

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Publications for Spastic Diplegia

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52PubMed
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Articles related to Spastic Diplegia:

(show top 50)    (show all 183)
idTitleAuthorsYear
1
Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. (23121133)
2013
2
Hip flexion deformity improves without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia. (22878968)
2012
3
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. (22200241)
2012
4
Rectus femoris distal tendon resection improves knee motion in patients with spastic diplegia. (21842297)
2012
5
Distal rectus femoris transfer as part of multilevel surgery in children with spastic diplegia--a randomized clinical trial. (22425637)
2012
6
Commentary on an article by Pamela Thomason, BPhty, MPT, et al.: "Single-event multilevel surgery in children with spastic diplegia. A pilot randomized controlled trial". (21368072)
2011
7
Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia. (21385750)
2011
8
Extraarticular subtalar arthrodesis for pes planovalgus: an interim result of 50 feet in patients with spastic diplegia. (20190996)
2010
9
Changes in lower limb rotation after soft tissue surgery in spastic diplegia. (20175660)
2010
10
Incidence of spinal abnormalities in patients with spastic diplegia 17 to 26 years after selective dorsal rhizotomy. (19784657)
2009
11
The outcome of intrathecal baclofen treatment on spastic diplegia: Preliminary results with a minimum of two year follow-up. (21791773)
2008
12
Reach performance and postural adjustments during standing in children with severe spastic diplegia using dynamic ankle-foot orthoses. (17999010)
2007
13
Are patients with hereditary spastic paraplegia different from patients with spastic diplegia during walking? Gait evaluation using 3D gait analysis. (17509240)
2007
14
Muscle contractile properties in children with spastic diplegia. (17418991)
2007
15
A clinical and etiologic profile of spastic diplegia. (16504791)
2006
16
Kinematic and kinetic evaluation of the ankle joint before and after tendo achilles lengthening in patients with spastic diplegia. (15958899)
2005
17
Proton magnetic resonance spectroscopy in children with spastic diplegia. (15157997)
2004
18
Conversion of biarticular to monoarticular muscles as a component of multilevel surgery in spastic diplegia. (14765875)
2004
19
A 2-year follow-up of outcomes following orthopedic surgery or selective dorsal rhizotomy in children with spastic diplegia. (15599225)
2004
20
Treatment of spastic diplegia in patients with cerebral palsy. (15076595)
2004
21
Wartenberg pendulum test: objective quantification of muscle tone in children with spastic diplegia undergoing selective dorsal rhizotomy. (11811646)
2002
22
Multilevel surgery in spastic diplegia: evaluation by physical examination and gait analysis in 25 children. (11856920)
2002
23
Syntelencephaly presenting with spastic diplegia. (11071147)
2000
24
Developmental sequence of postural control in prone position in children with spastic diplegia. (11102729)
2000
25
Construct validity of the In-Hand Manipulation Test: a discriminant analysis with children without disability and children with spastic diplegia. (10427678)
1999
26
Influence of infant-walkers on motor development: mimicking spastic diplegia? (10595672)
1999
27
Increased risk of spastic diplegia among very low birth weight children after preterm labor or prelabor rupture of membranes. (9544916)
1998
28
Ankle-foot orthoses for preambulatory children with spastic diplegia. (9150028)
1997
29
Daily physical activity of schoolchildren with spastic diplegia and of healthy control subjects. (7562279)
1995
30
Effects of quadriceps femoris muscle strengthening on crouch gait in children with spastic diplegia. (7644570)
1995
31
The cognitive development of children born preterm and affected by spastic diplegia. (8147501)
1993
32
The lumbar spine in spastic diplegia. A radiographic study. (8331105)
1993
33
Visuo-perceptual impairment and cerebral lesions in spastic diplegia with preterm birth. (1443403)
1992
34
Surgical management of spastic diplegia. (1445590)
1992
35
MR imaging of spastic diplegia. Comparative study between preterm and term infants. (2215901)
1990
36
Gross motor patterns in children with cerebral palsy and spastic diplegia. (2206157)
1990
37
Hereditary spastic diplegia with mental retardation in two young siblings. (2591069)
1989
38
Physical therapy for infants with spastic diplegia. (2920867)
1989
39
Effects of ankle-foot orthoses on functional motor performance in a child with spastic diplegia. (3740202)
1986
40
Pre- and postoperative gait analysis in patients with spastic diplegia: a preliminary report. (6511900)
1984
41
Hemorrhagic periventricular leukomalacia and spastic diplegia. (6701071)
1984
42
Spastic diplegia among children of low and normal birthweight. (6653904)
1983
43
Very low birthweight and subsequent neurological defect (with special reference to spastic diplegia). (1123121)
1975
44
Spastic diplegia after short gestation. (5463200)
1970
45
Spastic diplegia following mediastinal neuroblastoma. A case report. (5512975)
1970
46
Familial spastic diplegia due to anoxic encephalopathy (Alpers). A contribution to the study of vascular fragilities of the nervous system of genetic type. (5878525)
1965
47
The prehensile grasp of spastic diplegia. (13957620)
1963
48
WEIGHT LOSS IN PREMATURE INFANTS DEVELOPING SPASTIC DIPLEGIA. (14082279)
1963
49
Spastic Diplegia with Mental Defect. (19974783)
1910
50
A Case of Infantile Spastic Diplegia, with Tremors of the "Disseminated Sclerosis" Type. (20753356)
1891

Variations for Spastic Diplegia

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Expression for genes affiliated with Spastic Diplegia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spastic Diplegia

Search GEO for disease gene expression data for Spastic Diplegia.

Pathways for genes affiliated with Spastic Diplegia

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Spastic Diplegia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I38
valine degradation I38
pyruvate fermentation to lactate38
isoleucine degradation I38
9.6ALDH3A2, HSD17B10
2
Show member pathways
9.6ALDH3A2, HSD17B10
3
Show member pathways
Alzheimers Disease38
9.5NDUFV1, HSD17B10

Compounds for genes affiliated with Spastic Diplegia

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Spastic Diplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nad+459.6ALDH3A2, HSD17B10
2nad29 2410.0NDUFV1, ALDH3A2, HSD17B10
3nadh45 24 1110.8NDUFV1, ALDH3A2, HSD17B10

GO Terms for genes affiliated with Spastic Diplegia

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16Gene Ontology
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Cellular components related to Spastic Diplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057439.1NDUFV1, ALDH3A2, HSD17B10

Products for genes affiliated with Spastic Diplegia

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Sources for Spastic Diplegia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet