Aliases & Classifications for Spastic Diplegia

MalaCards integrated aliases for Spastic Diplegia:

Name: Spastic Diplegia 12 28 51 14
Diplegic Infantile Cerebral Palsy 12 69
Little's Disease 12 69
Cerebral Palsy 41 69
Cerebral Spastic Infantile Paralysis 12
Infantile Diplegic Cerebral Palsy 12
Infantile Spastic Cerebral Palsy 12
Spastic Cerebral Palsy 69
Littles Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10965
ICD10 32 G80.1
ICD9CM 34 343.0
MeSH 41 D002547
NCIt 46 C34781

Summaries for Spastic Diplegia

Disease Ontology : 12 A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. The legs cross at the knees, making it difficult to walk.

MalaCards based summary : Spastic Diplegia, also known as diplegic infantile cerebral palsy, is related to warburg micro syndrome 1 and warburg micro syndrome 4, and has symptoms including opisthotonus, muscle spasticity and sleeplessness. An important gene associated with Spastic Diplegia is ADD3 (Adducin 3), and among its related pathways/superpathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. The drugs Insulin Aspart and Zinc have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain.

Wikipedia : 72 Spastic diplegia, historically known as Little\'s Disease, is a form of cerebral palsy (CP) that is a... more...

Related Diseases for Spastic Diplegia

Diseases related to Spastic Diplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 warburg micro syndrome 1 31.0 RAB18 RAB3GAP1 RAB3GAP2 TBC1D20
2 warburg micro syndrome 4 31.0 RAB18 RAB3GAP1 RAB3GAP2 TBC1D20
3 warburg micro syndrome 2 30.8 RAB18 RAB3GAP1 RAB3GAP2 TBC1D20
4 spastic diplegia cerebral palsy 12.4
5 spastic diplegia and mental retardation 12.3
6 severe intellectual disability-progressive spastic diplegia syndrome 12.2
7 epilepsy, photogenic, with spastic diplegia and mental retardation 12.0
8 spastic hemiplegia 11.3
9 renpenning syndrome 1 11.3
10 paine syndrome 11.2
11 homocarnosinosis 11.1
12 warburg micro syndrome 3 11.1
13 spasticity 11.0
14 mental retardation, autosomal dominant 19 11.0
15 mental retardation, autosomal recessive 49 11.0
16 saccharopinuria 11.0
17 spastic paraplegia 20, autosomal recessive 11.0
18 brooks-wisniewski-brown syndrome 11.0
19 spastic paraplegia 2, x-linked 11.0
20 glycine encephalopathy 11.0
21 cerebritis 10.5
22 cerebral palsy 10.5
23 aging 10.2
24 periventricular leukomalacia 10.2
25 leukomalacia 10.2
26 hemiplegia 10.1
27 argininemia 10.0
28 ataxia and polyneuropathy, adult-onset 10.0
29 arthritis 10.0
30 hereditary spastic paraplegia 10.0
31 ichthyosis lamellar 1 10.0
32 quadriplegia 10.0
33 ichthyosis 10.0
34 paraplegia 10.0
35 encephalopathy 10.0
36 steroid-induced glaucoma 9.9 RAB3GAP1 RAB3GAP2
37 angelman syndrome 9.9
38 epicanthus 9.9
39 neuroblastoma 9.9
40 hsd10 mitochondrial disease 9.9
41 aceruloplasminemia 9.9
42 ataxia-oculomotor apraxia 3 9.9
43 hemangioma 9.9
44 holoprosencephaly 9.9
45 hydrocephalus 9.9
46 renal tubular acidosis 9.9
47 ptosis 9.9
48 blepharophimosis 9.9
49 microcephaly 9.9
50 myopathy 9.9

Comorbidity relations with Spastic Diplegia via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Spastic Diplegia:



Diseases related to Spastic Diplegia

Symptoms & Phenotypes for Spastic Diplegia

UMLS symptoms related to Spastic Diplegia:


opisthotonus, muscle spasticity, sleeplessness, myokymia, vertigo/dizziness, involuntary movements, abnormality of extrapyramidal motor function, asterixis, muscle fibrillation, chronic pain, tremor, torticollis, syncope, seizures, sciatica, pain, muscle rigidity, headache, dystonia, back pain, athetosis

Drugs & Therapeutics for Spastic Diplegia

Drugs for Spastic Diplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1571)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Aspart Approved Phase 4,Phase 3,Phase 2 116094-23-6 16132418
2
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 7440-66-6 32051 23994
3
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Phase 1 50-56-6 53477758 439302
4
Cefditoren Approved, Investigational Phase 4 104145-95-1, 117467-28-4 9870843 9571074
5
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
6
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
7
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
8
Tea tree oil Approved Phase 4
9
Tranylcypromine Approved, Investigational Phase 4,Phase 1 155-09-9 441233
10
Curcumin Approved, Investigational Phase 4,Phase 3,Phase 1 458-37-7 969516
11
Insulin Glargine Approved Phase 4,Phase 3,Phase 2 160337-95-1
12
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1 133107-64-9
13
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1 657-24-9 4091 14219
14
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5282411 5280427
15
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
16
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 1 171596-29-5 110635
17
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
18
Pitavastatin Approved Phase 4,Phase 3 147511-69-1, 147526-32-7 5282452 6366718
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
20
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
21
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
22
Varenicline Approved, Investigational Phase 4,Phase 3 249296-44-4 5310966
23
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
24
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
25
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2 198153-51-4 5360545
26
Ribavirin Approved Phase 4,Phase 2,Phase 3,Phase 1 36791-04-5 37542
27
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 129722-12-9 60795
28
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 159351-69-6 6442177
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
30
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53123-88-9 46835353 6436030 5284616
31
Chloroprocaine Approved Phase 4,Early Phase 1 133-16-4 8612
32
Levobupivacaine Approved, Investigational Phase 4,Phase 3 27262-47-1 92253
33
Procaine Approved, Investigational, Vet_approved Phase 4,Early Phase 1 59-46-1 4914
34
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
35
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 51-43-4 5816
36
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
37 Racepinephrine Approved Phase 4,Phase 2,Early Phase 1 329-65-7
38
Ropivacaine Approved Phase 4,Phase 3,Phase 1 84057-95-4 175805 71273
39
Nifedipine Approved Phase 4,Phase 1 21829-25-4 4485
40
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
41
Timolol Approved Phase 4,Phase 3,Phase 2 26839-75-8 5478 33624
42
Clonidine Approved Phase 4,Phase 3,Phase 2 4205-90-7 2803
43
Spironolactone Approved Phase 4,Phase 3 1952-01-7, 52-01-7 5833
44
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136470-78-5 441300 65140
45
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3 154598-52-4 64139
46
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2 134678-17-4 60825
47
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1 30516-87-1 35370
48
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
49
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
50
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294

Interventional clinical trials:

(show top 50) (show all 5830)

# Name Status NCT ID Phase Drugs
1 Prehypertension and Dietary Supplements - The PYRAMIDS Study Unknown status NCT01682291 Phase 4
2 Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes. Unknown status NCT00254085 Phase 4 Insulin Aspart
3 The Comparison of Oxytocin Induced Labor and Cook Balloon Induced Labor Unknown status NCT02202083 Phase 4
4 Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis Unknown status NCT01553006 Phase 4 cefditoren pivoxil
5 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
6 Effect of Rosuvastatin Therapy on HDL2 Level Unknown status NCT02593487 Phase 4 Rosuvastatin 10mg/d group;Rosuvastatin 20mg/d group
7 The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium Excretion Unknown status NCT02406443 Phase 4 Sitaglitpin
8 Effect of Different Mouthrinses in Plaque Formation Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
9 Tranylcypromine Treatment of Bipolar Depression Unknown status NCT01430455 Phase 4 Tranylcypromine
10 Curcumin Addition to Antipsychotic Treatment in Chronic Schizophrenia Patients Unknown status NCT02298985 Phase 4 Curcumin;placebo
11 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
12 The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders Unknown status NCT02357472 Phase 4 dehydroepiandrosterone
13 Effect of Acute Hyperglycemia on Renal Tissue Oxygenation Unknown status NCT02346149 Phase 4
14 Long Acting Phosphodiesterase 5 Inhibitors as Add-on Therapy for Patients With Pulmonary Hypertension Treated With Prostanoids. Unknown status NCT00705588 Phase 4 Tadalafil;Vardenafil
15 Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity Unknown status NCT01567774 Phase 4 Atorvastatin;Rosuvastatin
16 PharmacOdynamic compaRison of piTavastatin Versus atOrvastatin on Platelet Reactivity Unknown status NCT01648829 Phase 4 Atorvastatin;Pitavastatin
17 Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
18 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
19 Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics Unknown status NCT02389179 Phase 4 Vitamin D3
20 Smoking Cessation Treatment for Methadone Maintenance Patients Unknown status NCT01027754 Phase 4 Varenicline;Placebo
21 Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial Unknown status NCT00196703 Phase 4 memantine
22 Telaprevir in Genotype 3 HCV Unknown status NCT02087111 Phase 4 Telaprevir;40 Kd Pegylated interferon alfa 2a;Ribavirin
23 Improving Outcomes in Psychosis Associated With Substance Use Using Aripiprazole Unknown status NCT01155544 Phase 4
24 Effects of Atrial Rate-adaptive Pacing on Exercise Capacity in Patients With Chronic Heart Failure Complicated by Chronotropic Incompetence Unknown status NCT01016431 Phase 4
25 Targeted Indoor Residual Spraying Against Malaria Unknown status NCT02556242 Phase 4
26 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4 nucleoside analogue sparing HAART regimen
27 Positron Emission Tomography (PET)/Computed Tomography (CT) and Roentgen in Lung Cancer: Evaluation of Patients in General Practice Unknown status NCT00675168 Phase 4
28 Relationship Between Initial Plaque Characteristics and Stent Surface Coverage Patterns Unknown status NCT01024179 Phase 4
29 Determination of the Minimum Local Analgesic Dose of Spinal Chloroprocaine in Labour Unknown status NCT01909089 Phase 4 Spinal administration of chloroprocaine.
30 Herbal Alternatives for Menopause Symptoms (HALT Study) Unknown status NCT00169299 Phase 4 Black cohosh;Multibotanical preparation;Multibotanical preparation + dietary soy counseling;Conjugated equine estrogen +/- medroxyprogesterone acetate
31 Postoperative Pain Relief Following Total Hip Arthroplasty. A Comparison Between Intrathecal Morphine (IM) and Local Infiltration Analgesia (LIA) Unknown status NCT01281891 Phase 4 LIA;I/T morphine
32 The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers Unknown status NCT01526304 Phase 4
33 Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour Unknown status NCT02068404 Phase 4 Nifedipine
34 Safety and Efficacy of Intradermal Trivalent Influenza Vaccination in Institutionalized Older Adults Unknown status NCT01967368 Phase 4 Intanza;Vaxigrip
35 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
36 Resistant Hypertension Optimal Treatment Unknown status NCT01643434 Phase 4 Spironolactone;Clonidine
37 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
38 Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study Unknown status NCT02190019 Phase 4
39 Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs Unknown status NCT00011895 Phase 4 Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
40 Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly Completed NCT00018356 Phase 4 testosterone
41 Telemedicine Outreach for Post Traumatic Stress in CBOCs Completed NCT00821678 Phase 4
42 Facilitating the Adoption of Evidence-Based Depression Management in Substance Use Treatment Programs Completed NCT00137306 Phase 4
43 Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery Completed NCT01477151 Phase 4 Volatile anesthetic
44 Warfarine in Unexplained Oligohydramnios Completed NCT01569035 Phase 4 warfarin
45 Influenza Vaccination for Parents and Other Caregivers in the Pediatric Medical Home Completed NCT00812110 Phase 4 Influenzae vaccine
46 Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another Erythropoietin Completed NCT00210951 Phase 4
47 Joint Status in Subjects With Severe Hemophilia A in Relation to Different Treatment Regimens Completed NCT00927667 Phase 4
48 Effect of Electronic Cigarette Use on Cough Reflex Sensitivity Completed NCT02203162 Phase 4
49 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
50 Patients-ventilator Interaction During Sleep: Effect of Humidification System Completed NCT01038791 Phase 4

Search NIH Clinical Center for Spastic Diplegia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: cerebral palsy

Genetic Tests for Spastic Diplegia

Genetic tests related to Spastic Diplegia:

# Genetic test Affiliating Genes
1 Spastic Diplegia 28

Anatomical Context for Spastic Diplegia

MalaCards organs/tissues related to Spastic Diplegia:

38
Lung, Heart, Brain, Testes, Bone, Prostate, Kidney

Publications for Spastic Diplegia

Articles related to Spastic Diplegia:

(show top 50) (show all 217)
# Title Authors Year
1
Selective dorsal rhizotomy: A multidisciplinary approach to treating spastic diplegia. ( 28761524 )
2017
2
Regional anesthesia for a total knee arthroplasty on an adult patient with spastic diplegia and an intrathecal baclofen pump. ( 28913502 )
2017
3
Attenuation of temporal correlations of neuronal oscillations in patients with mild spastic diplegia. ( 29097718 )
2017
4
Spastic diplegia in preterm-born children: Executive function impairment and neuroanatomical correlates. ( 28073076 )
2017
5
How multi segmental patterns deviate in spastic diplegia from typical developed. ( 28806590 )
2017
6
Relation of selective voluntary motor control of the lower extremity and extensor strength of the knee joint in children with spastic diplegia. ( 27390436 )
2016
7
Altered Resting-State EEG Microstate Parameters and Enhanced Spatial Complexity in Male Adolescent Patients with Mild Spastic Diplegia. ( 27640158 )
2016
8
Intramuscular psoas lengthening during single-event multi-level surgery fails to improve hip dynamics in children with spastic diplegia. Clinical and kinematic outcomes in the short- and medium-terms. ( 27050557 )
2016
9
Impact of loaded sit-to-stand exercises at different speeds on the physiological cost of walking in children with spastic diplegia: A single-blind randomized clinical trial. ( 27394691 )
2016
10
Effects of Soft Tissue Surgery on Pelvic and Hip Rotation in Patients with Spastic Diplegia: A Meta-Analysis. ( 27247745 )
2016
11
Research of the spatial-temporal gait parameters and pressure characteristic in spastic diplegia children. ( 27405783 )
2016
12
Effect of task-oriented training and high-variability practice on gross motor performance and activities of daily living in children with spastic diplegia. ( 27821947 )
2016
13
Correlation between transverse plan kinematics and foot progression angle in children with spastic diplegia. ( 27902635 )
2016
14
Real-time feedback of dynamic foot pressure index for gait training of toe-walking children with spastic diplegia. ( 27558231 )
2016
15
Delayed finger tapping and cognitive responses in preterm-born male teenagers with mild spastic diplegia. ( 25693583 )
2015
16
Selective dorsal rhizotomy for spastic diplegia secondary to stroke in an adult patient. ( 26167363 )
2015
17
Effects of trunk-hip strengthening on standing in children with spastic diplegia: a comparative pilot study. ( 26157214 )
2015
18
Plasma Tumor Necrosis Factor-alpha (TNF-I+) Levels Correlate with Disease Severity in Spastic Diplegia, Triplegia, and Quadriplegia in Children with Cerebral Palsy. ( 26656070 )
2015
19
Patellar tendon shortening for flexed knee gait in spastic diplegia. ( 25701014 )
2015
20
Keyhole interlaminar dorsal rhizotomy for spastic diplegia in cerebral palsy. ( 26002713 )
2015
21
Effects of the standing program with hip abduction on hip acetabular development in children with spastic diplegia cerebral palsy. ( 26517269 )
2015
22
Communication skills in individuals with spastic diplegia. ( 26107078 )
2015
23
The differential diagnosis of spastic diplegia. ( 25700542 )
2015
24
A Descriptive Study of Lower Limb Torsional Kinematic Profiles in Children With Spastic Diplegia. ( 25333905 )
2014
25
Comparison of children with joint angles in spastic diplegia with those of normal children. ( 25276040 )
2014
26
Ankle-foot orthoses management in children with spastic diplegia: re: day vs. day-night use of ankle-foot orthoses in young children with spastic diplegia. ( 24658426 )
2014
27
Sit-to-stand movement changes in preschool-aged children with spastic diplegia following one neurodevelopmental treatment session - a pilot study. ( 25327772 )
2014
28
Correlations between gross motor functions and health-related quality of life in Thai children with spastic diplegia. ( 25518314 )
2014
29
Electrical Stimulation Following Botulinum Toxin A in Children With Spastic Diplegia: A Within-Participant Randomized Pilot Study. ( 25529410 )
2014
30
Altered trunk movements during gait in children with spastic diplegia: compensatory or underlying trunk control deficit? ( 24864057 )
2014
31
Long-term effects after conversion of biarticular to monoarticular muscles compared with musculotendinous lengthening in children with spastic diplegia. ( 23018029 )
2013
32
Reliability of head and trunk kinematics during gait in children with spastic diplegia. ( 23062729 )
2013
33
Spastic diplegia in children with HIV encephalopathy: first description of gait and physical status. ( 24182356 )
2013
34
Short-term effects of proximal femoral derotation osteotomy on kinematics in ambulatory patients with spastic diplegia. ( 23531549 )
2013
35
Full body gait analysis may improve diagnostic discrimination between hereditary spastic paraplegia and spastic diplegia: a preliminary study. ( 23085499 )
2013
36
Three-dimensional head and trunk movement characteristics during gait in children with spastic diplegia. ( 23597939 )
2013
37
Effects of vojta therapy on gait of children with spastic diplegia. ( 24409030 )
2013
38
Long term outcome of single event multilevel surgery in spastic diplegia with flexed knee gait. ( 23041270 )
2013
39
Day vs. day-night use of ankle-foot orthoses in young children with spastic diplegia: a randomized controlled study. ( 23739274 )
2013
40
Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. ( 23121133 )
2013
41
The impacts of hinged and solid ankle-foot orthoses on standing and walking in children with spastic diplegia. ( 24665312 )
2013
42
Hip flexion deformity improves without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia. ( 22878968 )
2012
43
Blepharophimosis-ptosis-epicanthus inversus syndrome plus: deletion 3q22.3q23 in a patient with characteristic facial features and with genital anomalies, spastic diplegia, and speech delay. ( 21934608 )
2012
44
Kinematic and electromyographic studies on unaided, unilateral and bilateral crutch walking in adolescents with spastic diplegia. ( 22130909 )
2012
45
Development of knee function after hamstring lengthening as a part of multilevel surgery in children with spastic diplegia: a long-term outcome study. ( 22257998 )
2012
46
Distal rectus femoris transfer as part of multilevel surgery in children with spastic diplegia--a randomized clinical trial. ( 22425637 )
2012
47
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. ( 22200241 )
2012
48
Long-term outcome of femoral derotation osteotomy in children with spastic diplegia. ( 22766044 )
2012
49
Rectus femoris distal tendon resection improves knee motion in patients with spastic diplegia. ( 21842297 )
2012
50
Argininemia presenting with progressive spastic diplegia. ( 21310339 )
2011

Variations for Spastic Diplegia

ClinVar genetic disease variations for Spastic Diplegia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ADD3 NM_016824.4(ADD3): c.1100G> A (p.Gly367Asp) single nucleotide variant Pathogenic rs564185858 GRCh37 Chromosome 10, 111882007: 111882007

Expression for Spastic Diplegia

Search GEO for disease gene expression data for Spastic Diplegia.

Pathways for Spastic Diplegia

GO Terms for Spastic Diplegia

Cellular components related to Spastic Diplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.02 ALDH3A2 RAB18 RAB3GAP1 RAB3GAP2 TBC1D20
2 endoplasmic reticulum tubular network GO:0071782 8.96 RAB18 RAB3GAP1

Biological processes related to Spastic Diplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.54 RAB3GAP1 RAB3GAP2 TBC1D20
2 regulation of GTPase activity GO:0043087 9.43 RAB3GAP1 RAB3GAP2
3 camera-type eye development GO:0043010 9.4 RAB3GAP1 TBC1D20
4 positive regulation of autophagosome assembly GO:2000786 9.32 RAB3GAP1 RAB3GAP2
5 positive regulation of endoplasmic reticulum tubular network organization GO:1903373 9.26 RAB3GAP1 RAB3GAP2
6 positive regulation of protein lipidation GO:1903061 9.16 RAB3GAP1 RAB3GAP2
7 establishment of protein localization to endoplasmic reticulum membrane GO:0097051 8.96 RAB3GAP1 RAB3GAP2
8 lipid particle organization GO:0034389 8.8 RAB18 RAB3GAP1 TBC1D20

Molecular functions related to Spastic Diplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.26 ADD3 TUBB3
2 Rab guanyl-nucleotide exchange factor activity GO:0017112 9.16 RAB3GAP1 RAB3GAP2
3 GTPase activator activity GO:0005096 9.13 RAB3GAP1 RAB3GAP2 TBC1D20
4 Rab GTPase binding GO:0017137 8.8 RAB3GAP1 RAB3GAP2 TBC1D20

Sources for Spastic Diplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....