MCID: SPS005
MIFTS: 39

Spastic Hemiplegia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Spastic Hemiplegia

MalaCards integrated aliases for Spastic Hemiplegia:

Name: Spastic Hemiplegia 12 14
Spastic Hemiplegic Cerebral Palsy 12 49 69
Hemiplegic Cerebral Palsy 12 69
Hemiplegic Infantile Cerebral Palsy 12
Cerebral Palsy Spastic Hemiplegic 49
Spastic Hemiplegia Cerebral Palsy 49
Congenital Hemiplegia 12
Hemiplegia, Spastic 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10967
ICD9CM 34 343.1
SNOMED-CT 64 258714003 43486001
ICD10 32 G80.2 G81.1

Summaries for Spastic Hemiplegia

Disease Ontology : 12 A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally.

MalaCards based summary : Spastic Hemiplegia, also known as spastic hemiplegic cerebral palsy, is related to porencephaly and hemiplegia, and has symptoms including other specified hemiplegia, spastic hemiplegia and hemiparesis affecting nondominant side and spastic hemiplegia and hemiparesis affecting dominant side. An important gene associated with Spastic Hemiplegia is CAPN15 (Calpain 15). The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Wikipedia : 72 Spastic hemiplegia is a neuromuscular condition of spasticity that results in the muscles on one side of... more...

Related Diseases for Spastic Hemiplegia

Graphical network of the top 20 diseases related to Spastic Hemiplegia:



Diseases related to Spastic Hemiplegia

Symptoms & Phenotypes for Spastic Hemiplegia

UMLS symptoms related to Spastic Hemiplegia:


other specified hemiplegia, spastic hemiplegia and hemiparesis affecting nondominant side, spastic hemiplegia and hemiparesis affecting dominant side, hemiplegia, flaccid, opisthotonus, muscle spasticity, hemiplegia, hemiparesis

Drugs & Therapeutics for Spastic Hemiplegia

Drugs for Spastic Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Not Applicable 51-84-3 187
2 Botulinum Toxins Phase 4,Phase 3,Not Applicable
3 Cholinergic Agents Phase 4,Phase 3,Not Applicable
4 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Not Applicable
5 abobotulinumtoxinA Phase 4,Phase 3,Not Applicable
6 Botulinum Toxins, Type A Phase 4,Phase 3,Not Applicable
7 Neuromuscular Agents Phase 4,Phase 3
8 onabotulinumtoxinA Phase 4,Phase 3,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Phase 3
10
Citalopram Approved Phase 1 59729-33-8 2771
11
Serotonin Phase 1 50-67-9 5202
12 Serotonin Agents Phase 1
13
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
14
Menthol Approved ,Not Applicable 2216-51-5 16666
15 Antipruritics
16 Dermatologic Agents
17 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show top 50) (show all 55)

# Name Status NCT ID Phase Drugs
1 The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 4
2 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) Active, not recruiting NCT02969356 Phase 4 AbobotulinumtoxinA (Dysport®)
3 HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
4 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
5 Dysport® Adult Upper Limb Spasticity Completed NCT01313299 Phase 3 Botulinum type A toxin (Dysport®);Botulinum type A toxin (Dysport®);Placebo
6 Dysport® Adult Upper Limb Spasticity Extension Study Completed NCT01313312 Phase 3 Dysport®
7 Dysport® Adult Lower Limb Spasticity Follow-on Study Completed NCT01251367 Phase 3 Dysport®
8 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
9 Bimanual Training in Children With Hemiplegia With Lower Limb and Postural Stimulation (HABIT & Leg) Unknown status NCT01700777 Phase 1, Phase 2
10 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
11 A Trial Comparing Two Methods of CIMT in the Hemiplegic Child Completed NCT01770678 Phase 2
12 Children With Hemiparesis Arm and Hand Movement Project (CHAMP Study) Recruiting NCT01895660 Phase 2
13 Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy Unknown status NCT00305006 Phase 1
14 Enhanced Motor Recovery Using Serotonergic Agents in Stroke Completed NCT01751854 Phase 1 SSRI;Placebo
15 Virtual Therapy in Rehabilitation Spastic Hemiparesis Unknown status NCT02061371
16 Analysis of the Electrical Muscle Activity and Resistance to Movement in Spastic Hemiparetic Patients. Unknown status NCT01945151
17 Immediate Effect of Laser on Spasticity Unknown status NCT02014935
18 Method Pilates X Pilates in Water Postural Alignment and Its Correlation With Respiratory Capacity With Hemiparesis Spastic Unknown status NCT02065505
19 Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy Unknown status NCT02458612 Not Applicable
20 Constraint-induced Movement Therapy and Hand Arm Bimanual Training in Children With Hemiplegic Cerebral Palsy (CP) Unknown status NCT01078766 Not Applicable
21 Motor Learning in People With Cerebral Palsy by Using Virtual Reality. Completed NCT03348943
22 Validity of Manipulation Taxonomy of Spastic Hemiplegic Cerebral Palsy (CP) Forms Completed NCT01157494
23 Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy Completed NCT00100503
24 Brain Control of Movements in Cerebral Palsy Completed NCT00076596
25 Eye-Hand Coordination in Children With Spastic Diplegia Completed NCT00024791
26 Progressive Functional Strength Training in Unilateral Spastic Cerebral Palsy Completed NCT02460406 Not Applicable
27 Functional Electrical Stimulation for Hemiplegic Cerebral Palsy Completed NCT01817179 Not Applicable
28 "Remind to Move" Treatment Versus Constraint-induced Movement Therapy for Children With Hemiplegic Cerebral Palsy Completed NCT02645331 Not Applicable
29 Improving Gait and Balance in Children With Hemiplegic Cerebral Palsy: Gait Myoelectric Stimulator Study Completed NCT03226860 Not Applicable
30 PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy Completed NCT02131909 Not Applicable
31 Loading Gait in Spatic Cerebral Palsy Completed NCT02010736 Not Applicable
32 Constraint-induced Movement Therapy and Self-regulation for Children With Cerebral Palsy Completed NCT02957708 Not Applicable
33 Functional Electrical Stimulation (FES) for Upper Extremity Hemiplegia in Children With Cerebral Palsy Completed NCT03016923 Not Applicable
34 Constraint Induced Movement Therapy (CIMT)- Neuroimaging Predictors of Positive Response to Constraint Completed NCT01643109 Not Applicable
35 Camp High 5: Evaluation of the Effect on Upper Limb Function Completed NCT02875054 Not Applicable
36 Muscle Activity With the Use of Ankle Foot Orthoses in Cerebral Palsy Completed NCT00462085 Not Applicable
37 Enhancing Recovery of Arm Movement in Stroke Patients Recruiting NCT02725853
38 Upper Limb Botulinum Toxin Injection Combined With Self Rehabilitation Recruiting NCT02699762
39 tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy Recruiting NCT03402854
40 Database for Stroke in Infants and Children Recruiting NCT00084292
41 The Effects of Virtual Reality on Upper Extremity Function in Hemiplegic Cerebral Palsy Recruiting NCT02841319 Not Applicable
42 Contralaterally Controlled FES for Hand Opening in Hemiplegic Cerebral Palsy Recruiting NCT02925455 Not Applicable
43 A Comparative Analysis on Physical Activity Performance and Motor Function of Affected Upper Extremity Before and After a CIMT Program in Young Children With Hemiparetic Cerebral Palsy Recruiting NCT03418519 Not Applicable
44 A Study on Safety of tDCS One-shot in UCP Recruiting NCT03137940 Not Applicable
45 Changes in Muscle Activity of Children With Spastic Unilat Cerebral Palsy Using 2 Types of Ankle-foot Orthoses to Walk Recruiting NCT03361930 Not Applicable
46 AOT and ICT for Hemiplegia Recruiting NCT03094455 Not Applicable
47 Actigraphs for Detection of Asymmetries Recruiting NCT03054441
48 tDCS and Robotic Training in Adults With Cerebral Palsy Recruiting NCT03038269 Not Applicable
49 Spine Biomechanics During Gait Following Lower Extremity Treatment in Different Patient Groups Recruiting NCT01803243 Not Applicable
50 Improving Holding Function of the Hemiplegic Hand Active, not recruiting NCT02459951

Search NIH Clinical Center for Spastic Hemiplegia

Genetic Tests for Spastic Hemiplegia

Anatomical Context for Spastic Hemiplegia

MalaCards organs/tissues related to Spastic Hemiplegia:

38
Brain, Eye, Testes, Spinal Cord, Bone

Publications for Spastic Hemiplegia

Articles related to Spastic Hemiplegia:

(show top 50) (show all 113)
# Title Authors Year
1
Rewiring to Regain Function in Patients with Spastic Hemiplegia. ( 29261362 )
2018
2
Ocular Motor Function in Children with Spastic Hemiplegia Evaluated by the Ocular Motor Score. ( 28771056 )
2017
3
Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia. ( 28131185 )
2017
4
Three consecutive neurotomies in one patient for the treatment of spastic hemiplegia: Spinal, median, and foot toes common flexor. ( 29184718 )
2017
5
Does unilateral single-event multilevel surgery improve gait in children with spastic hemiplegia? A retrospective analysis of a long-term follow-up. ( 27907872 )
2016
6
Synergistic effect of moxibustion and rehabilitation training in functional recovery of post-stroke spastic hemiplegia. ( 27261982 )
2016
7
Effects of concentric and eccentric control exercise on gross motor function and balance ability of paretic leg in children with spastic hemiplegia. ( 27512281 )
2016
8
Altered force perception in stroke survivors with spastic hemiplegia. ( 26550912 )
2015
9
A Novel Use of Regional Anesthesia for Spastic Hemiplegia Evaluation and Treatment: A Case Report. ( 26253247 )
2015
10
Hereditary diffuse leukoencephalopathy with spheroids characterized by spastic hemiplegia preceding mental impairment. ( 24930661 )
2014
11
Rapid On-Line Control to Reaching Is Preserved in Children With Congenital Spastic Hemiplegia: Evidence From Double-Step Reaching Performance. ( 25480803 )
2014
12
Effects of Task-oriented Approach on Affected Arm Function in Children with Spastic Hemiplegia Due to Cerebral Palsy. ( 25013269 )
2014
13
Motion of the center of mass in children with spastic hemiplegia: balance, energy transfer, and work performed by the affected leg vs. the unaffected leg. ( 24119778 )
2014
14
Immediate effect of Walkbot robotic gait training on neuromechanical knee stiffness in spastic hemiplegia: a case report. ( 23867409 )
2013
15
Practicing a matching movement with a mirror in individuals with spastic hemiplegia. ( 23751296 )
2013
16
Passive stiffness of the gastrocnemius muscle in athletes with spastic hemiplegic cerebral palsy. ( 23689294 )
2013
17
Ankle dorsiflexor, not plantarflexor strength, predicts the functional mobility of people with spastic hemiplegia. ( 23793340 )
2013
18
Effects of self-controlled feedback on learning of a throwing task in children with spastic hemiplegic cerebral palsy. ( 23810928 )
2013
19
Motor imagery of the unaffected hand in children with spastic hemiplegia. ( 22292833 )
2012
20
Contribution of ankle dorsiflexor strength to walking endurance in people with spastic hemiplegia after stroke. ( 22440486 )
2012
21
Abnormalities in the uninvolved foot in children with spastic hemiplegia. ( 22892623 )
2012
22
Muscle releases to improve passive motion and relieve pain in patients with spastic hemiplegia and elbow flexion contractures. ( 22217645 )
2012
23
Multilevel surgery improves gait in spastic hemiplegia but does not resolve hip dysplasia. ( 21984351 )
2012
24
Shoulder tenotomies to improve passive motion and relieve pain in patients with spastic hemiplegia after upper motor neuron injury. ( 21232986 )
2011
25
A comparison of motor imagery performance in children with spastic hemiplegia and developmental coordination disorder. ( 21058119 )
2011
26
Two-dimensional analysis of gait asymmetry in spastic hemiplegia. ( 26760152 )
2010
27
Effect of addition of botulinum toxin-A to standardized therapy for dynamic manual skills measured with kinematic aiming tasks in children with spastic hemiplegia. ( 20461335 )
2010
28
Follow-up motion laboratory analysis for patients with spastic hemiplegia due to cerebral palsy: analysis of the flexor carpi ulnaris firing pattern before and after tendon transfer surgery. ( 20022711 )
2010
29
Botulinum toxin-a in children with congenital spastic hemiplegia does not improve upper extremity motor-related function over rehabilitation alone: a randomized controlled trial. ( 19106252 )
2009
30
Fast responses to target changes are not impaired in children with spastic hemiplegia. ( 18987560 )
2009
31
Long-term outcome of superficialis-to-profundus tendon transfer in patients with clenched fist due to spastic hemiplegia. ( 17852274 )
2008
32
Quantitative and qualitative functional evaluation of upper extremity tendon transfers in spastic hemiplegia caused by cerebral palsy. ( 18724208 )
2008
33
Residual pelvic rotation after single-event multilevel surgery in spastic hemiplegia. ( 18757966 )
2008
34
Shoulder pain and external rotation in spastic hemiplegia do not improve by injection of botulinum toxin A into the subscapular muscle. ( 18408090 )
2008
35
Effect of wrist hand splints on grip, pinch, manual dexterity, and muscle activation in children with spastic hemiplegia: a preliminary study. ( 18215750 )
2008
36
Kinesthetic ability in children with spastic hemiplegia. ( 18042970 )
2007
37
A preliminary study into the criterion validity of the Modified Modified Ashworth Scale using the new measure of the alpha motoneuron excitability in spastic hemiplegia. ( 17557652 )
2007
38
Treatment of shoulder pain in spastic hemiplegia by reducing spasticity of the subscapular muscle: a randomised, double blind, placebo controlled study of botulinum toxin A. ( 17088333 )
2007
39
Gait strategy of uninvolved limb in children with spastic hemiplegia. ( 17259912 )
2007
40
How do we get better outcome with botulinum toxin in the treatment of children with spastic hemiplegia? ( 17589419 )
2007
41
Kinematic aiming task: measuring functional changes in hand and arm movements after botulinum toxin-A injections in children with spastic hemiplegia. ( 17581288 )
2007
42
Anomalous median nerve position dorsal to the flexor tendons in a patient with spastic hemiplegia and wrist pain: case report. ( 17606068 )
2007
43
Children with congenital spastic hemiplegia obey Fitts' Law in a visually guided tapping task. ( 17019607 )
2007
44
The use of dynamic EMG in predicting the outcome of split posterior tibial tendon transfers in spastic hemiplegia. ( 17065945 )
2006
45
Clinician agreement on gait pattern ratings in children with spastic hemiplegia. ( 16700932 )
2006
46
MRT-measurements of muscle volumes of the lower extremities of youths with spastic hemiplegia caused by cerebral palsy. ( 16690238 )
2006
47
Muscle force generation and force control of finger movements in children with spastic hemiplegia during isometric tasks. ( 15892376 )
2005
48
Multilevel orthopaedic surgery in group IV spastic hemiplegia. ( 15795209 )
2005
49
Children with spastic hemiplegia are equally able as controls in maintaining a precise percentage of maximum force without visually monitoring their performance. ( 16168734 )
2005
50
Novel approach for spastic hemiplegia classification through the use of support vector machines. ( 17271714 )
2004

Variations for Spastic Hemiplegia

Expression for Spastic Hemiplegia

Search GEO for disease gene expression data for Spastic Hemiplegia.

Pathways for Spastic Hemiplegia

GO Terms for Spastic Hemiplegia

Biological processes related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 8.8 BCL2L11 COL4A1 SIX3

Sources for Spastic Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....