MCID: SPS005
MIFTS: 37

Spastic Hemiplegia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Spastic Hemiplegia

MalaCards integrated aliases for Spastic Hemiplegia:

Name: Spastic Hemiplegia 12 14
Spastic Hemiplegic Cerebral Palsy 12 50 69
Hemiplegic Cerebral Palsy 12 69
Hemiplegic Infantile Cerebral Palsy 12
Cerebral Palsy Spastic Hemiplegic 50
Spastic Hemiplegia Cerebral Palsy 50
Congenital Hemiplegia 12
Hemiplegia, Spastic 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10967
ICD9CM 35 343.1
SNOMED-CT 64 258714003 43486001
ICD10 33 G80.2 G81.1
UMLS 69 C0270805

Summaries for Spastic Hemiplegia

Disease Ontology : 12 A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally.

MalaCards based summary : Spastic Hemiplegia, also known as spastic hemiplegic cerebral palsy, is related to hemiplegia and porencephaly, and has symptoms including hemiparesis, hemiplegia and muscle spasticity. An important gene associated with Spastic Hemiplegia is CAPN15 (Calpain 15). The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Wikipedia : 72 Spastic hemiplegia is a neuromuscular condition of spasticity that results in the muscles on one side of... more...

Related Diseases for Spastic Hemiplegia

Graphical network of the top 20 diseases related to Spastic Hemiplegia:



Diseases related to Spastic Hemiplegia

Symptoms & Phenotypes for Spastic Hemiplegia

UMLS symptoms related to Spastic Hemiplegia:


hemiparesis, hemiplegia, muscle spasticity, opisthotonus, hemiplegia, flaccid, spastic hemiplegia and hemiparesis affecting dominant side, spastic hemiplegia and hemiparesis affecting nondominant side, other specified hemiplegia

Drugs & Therapeutics for Spastic Hemiplegia

Drugs for Spastic Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3 51-84-3 187
2 Botulinum Toxins Phase 4,Phase 3
3 Cholinergic Agents Phase 4,Phase 3
4 Neurotransmitter Agents Phase 4,Phase 3,Phase 1
5 abobotulinumtoxinA Phase 4,Phase 3
6 Botulinum Toxins, Type A Phase 4,Phase 3
7 Neuromuscular Agents Phase 4,Phase 3
8 onabotulinumtoxinA Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3
10
Citalopram Approved Phase 1 59729-33-8 2771
11
Serotonin Phase 1 50-67-9 5202
12 Serotonin Agents Phase 1
13
Diazepam Approved, Illicit, Vet_approved 439-14-5 3016
14
Lidocaine Approved, Vet_approved 137-58-6 3676
15 Anesthetics
16 Anesthetics, Local
17 Anti-Arrhythmia Agents
18 Central Nervous System Depressants
19 Diuretics, Potassium Sparing
20 Sodium Channel Blockers
21 Analgesics

Interventional clinical trials:

(show all 33)

id Name Status NCT ID Phase Drugs
1 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) Recruiting NCT02969356 Phase 4 AbobotulinumtoxinA (Dysport®)
2 Upper Limb Botulinum Toxin Injection Combined With Self Rehabilitation Recruiting NCT02699762 Phase 4
3 Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox) Recruiting NCT02888548 Phase 4
4 The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Not yet recruiting NCT02944929 Phase 4
5 HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
6 Dysport® Adult Upper Limb Spasticity Completed NCT01313299 Phase 3 Botulinum type A toxin (Dysport®);Botulinum type A toxin (Dysport®);Placebo
7 Dysport® Adult Lower Limb Spasticity Follow-on Study Completed NCT01251367 Phase 3 Dysport
8 Dysport® Adult Upper Limb Spasticity Extension Study Completed NCT01313312 Phase 3 Dysport®
9 MEOPA to Improve Physical Therapy Results After Multilevel Surgery Completed NCT00632528 Phase 3 MEOPA;Medicinal air
10 Enhanced Motor Recovery Using Serotonergic Agents in Stroke Completed NCT01751854 Phase 1 SSRI;Placebo
11 Virtual Therapy in Rehabilitation Spastic Hemiparesis Unknown status NCT02061371
12 Analysis of the Electrical Muscle Activity and Resistance to Movement in Spastic Hemiparetic Patients. Unknown status NCT01945151
13 Immediate Effect of Laser on Spasticity Unknown status NCT02014935
14 Method Pilates X Pilates in Water Postural Alignment and Its Correlation With Respiratory Capacity With Hemiparesis Spastic Unknown status NCT02065505
15 Validity of Manipulation Taxonomy of Spastic Hemiplegic Cerebral Palsy (CP) Forms Completed NCT01157494
16 Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy Completed NCT00100503
17 Brain Control of Movements in Cerebral Palsy Completed NCT00076596
18 Eye-Hand Coordination in Children With Spastic Diplegia Completed NCT00024791
19 Evaluation of the Effect of an Ankle Foot Orthoses for Ambulatory Function Completed NCT01336517
20 Intensive Home-based Bimanual and Lower-limb Training in Young Children With Hemiplegia Completed NCT02299284
21 Determine the Main Muscle Participant in the Deformation of the Elbow in Hemiplegic Patients Completed NCT02455232 4cc of lidocaïne®
22 Effectiveness of NeuroMuscular Taping on Painful Hemiplegic Shoulder Completed NCT02254876
23 Measurement by 2D Ultrasound of the Pennation Angle and Elasticity of Gastrocnemius Muscle Completed NCT02549807
24 Shoulder Passive Range of Motion and Positioning Exercise on Hemiplegic Stroke Patients Completed NCT03045432
25 Muscular Strengthening for Paretic Knee Flexor and Extensor by Conventional Physiotherapy on Chronic Hemiplegic Stroke Patients Completed NCT00570570
26 Enhancing Recovery of Arm Movement in Stroke Patients Recruiting NCT02725853
27 Database for Stroke in Infants and Children Recruiting NCT00084292
28 Effect of Taping in the Hemiplegic Patient With a Deficit of the Footbrowers Recruiting NCT03284606
29 Improving Holding Function of the Hemiplegic Hand Active, not recruiting NCT02459951
30 Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke Patients Not yet recruiting NCT03024190
31 Changes in Echogenicity and Muscle Stiffness in Elastography After Botulinum Toxin Injection a Spastic Muscle Terminated NCT02550509
32 Evaluation of Walking After Repetitive Transcranial Magnetic Stimulation (rTMS) Inhibitory 1Hz in Vascular Hemiplegia Terminated NCT01567332
33 Dynamic Splinting for Plantarflexion in Spastic Hemiplegia Withdrawn NCT01329705

Search NIH Clinical Center for Spastic Hemiplegia

Genetic Tests for Spastic Hemiplegia

Anatomical Context for Spastic Hemiplegia

MalaCards organs/tissues related to Spastic Hemiplegia:

39
Brain, Eye, Testes, Bone, Spinal Cord

Publications for Spastic Hemiplegia

Articles related to Spastic Hemiplegia:

(show top 50) (show all 109)
id Title Authors Year
1
Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia. ( 28131185 )
2017
2
Ocular Motor Function in Children with Spastic Hemiplegia Evaluated by the Ocular Motor Score. ( 28771056 )
2017
3
Does unilateral single-event multilevel surgery improve gait in children with spastic hemiplegia? A retrospective analysis of a long-term follow-up. ( 27907872 )
2016
4
Synergistic effect of moxibustion and rehabilitation training in functional recovery of post-stroke spastic hemiplegia. ( 27261982 )
2016
5
Effects of concentric and eccentric control exercise on gross motor function and balance ability of paretic leg in children with spastic hemiplegia. ( 27512281 )
2016
6
A Novel Use of Regional Anesthesia for Spastic Hemiplegia Evaluation and Treatment: A Case Report. ( 26253247 )
2015
7
Altered force perception in stroke survivors with spastic hemiplegia. ( 26550912 )
2015
8
Motion of the center of mass in children with spastic hemiplegia: balance, energy transfer, and work performed by the affected leg vs. the unaffected leg. ( 24119778 )
2014
9
Rapid On-Line Control to Reaching Is Preserved in Children With Congenital Spastic Hemiplegia: Evidence From Double-Step Reaching Performance. ( 25480803 )
2014
10
Effects of Task-oriented Approach on Affected Arm Function in Children with Spastic Hemiplegia Due to Cerebral Palsy. ( 25013269 )
2014
11
Hereditary diffuse leukoencephalopathy with spheroids characterized by spastic hemiplegia preceding mental impairment. ( 24930661 )
2014
12
Immediate effect of Walkbot robotic gait training on neuromechanical knee stiffness in spastic hemiplegia: a case report. ( 23867409 )
2013
13
Practicing a matching movement with a mirror in individuals with spastic hemiplegia. ( 23751296 )
2013
14
Ankle dorsiflexor, not plantarflexor strength, predicts the functional mobility of people with spastic hemiplegia. ( 23793340 )
2013
15
Contribution of ankle dorsiflexor strength to walking endurance in people with spastic hemiplegia after stroke. ( 22440486 )
2012
16
Motor imagery of the unaffected hand in children with spastic hemiplegia. ( 22292833 )
2012
17
Muscle releases to improve passive motion and relieve pain in patients with spastic hemiplegia and elbow flexion contractures. ( 22217645 )
2012
18
Multilevel surgery improves gait in spastic hemiplegia but does not resolve hip dysplasia. ( 21984351 )
2012
19
Abnormalities in the uninvolved foot in children with spastic hemiplegia. ( 22892623 )
2012
20
Shoulder tenotomies to improve passive motion and relieve pain in patients with spastic hemiplegia after upper motor neuron injury. ( 21232986 )
2011
21
A comparison of motor imagery performance in children with spastic hemiplegia and developmental coordination disorder. ( 21058119 )
2011
22
Effect of addition of botulinum toxin-A to standardized therapy for dynamic manual skills measured with kinematic aiming tasks in children with spastic hemiplegia. ( 20461335 )
2010
23
Follow-up motion laboratory analysis for patients with spastic hemiplegia due to cerebral palsy: analysis of the flexor carpi ulnaris firing pattern before and after tendon transfer surgery. ( 20022711 )
2010
24
Two-dimensional analysis of gait asymmetry in spastic hemiplegia. ( 26760152 )
2010
25
Botulinum toxin-a in children with congenital spastic hemiplegia does not improve upper extremity motor-related function over rehabilitation alone: a randomized controlled trial. ( 19106252 )
2009
26
Fast responses to target changes are not impaired in children with spastic hemiplegia. ( 18987560 )
2009
27
Residual pelvic rotation after single-event multilevel surgery in spastic hemiplegia. ( 18757966 )
2008
28
Effect of wrist hand splints on grip, pinch, manual dexterity, and muscle activation in children with spastic hemiplegia: a preliminary study. ( 18215750 )
2008
29
Quantitative and qualitative functional evaluation of upper extremity tendon transfers in spastic hemiplegia caused by cerebral palsy. ( 18724208 )
2008
30
Shoulder pain and external rotation in spastic hemiplegia do not improve by injection of botulinum toxin A into the subscapular muscle. ( 18408090 )
2008
31
Long-term outcome of superficialis-to-profundus tendon transfer in patients with clenched fist due to spastic hemiplegia. ( 17852274 )
2008
32
Kinematic aiming task: measuring functional changes in hand and arm movements after botulinum toxin-A injections in children with spastic hemiplegia. ( 17581288 )
2007
33
A preliminary study into the criterion validity of the Modified Modified Ashworth Scale using the new measure of the alpha motoneuron excitability in spastic hemiplegia. ( 17557652 )
2007
34
Kinesthetic ability in children with spastic hemiplegia. ( 18042970 )
2007
35
Children with congenital spastic hemiplegia obey Fitts' Law in a visually guided tapping task. ( 17019607 )
2007
36
Anomalous median nerve position dorsal to the flexor tendons in a patient with spastic hemiplegia and wrist pain: case report. ( 17606068 )
2007
37
Gait strategy of uninvolved limb in children with spastic hemiplegia. ( 17259912 )
2007
38
How do we get better outcome with botulinum toxin in the treatment of children with spastic hemiplegia? ( 17589419 )
2007
39
Treatment of shoulder pain in spastic hemiplegia by reducing spasticity of the subscapular muscle: a randomised, double blind, placebo controlled study of botulinum toxin A. ( 17088333 )
2007
40
The use of dynamic EMG in predicting the outcome of split posterior tibial tendon transfers in spastic hemiplegia. ( 17065945 )
2006
41
MRT-measurements of muscle volumes of the lower extremities of youths with spastic hemiplegia caused by cerebral palsy. ( 16690238 )
2006
42
Clinician agreement on gait pattern ratings in children with spastic hemiplegia. ( 16700932 )
2006
43
Children with spastic hemiplegia are equally able as controls in maintaining a precise percentage of maximum force without visually monitoring their performance. ( 16168734 )
2005
44
Multilevel orthopaedic surgery in group IV spastic hemiplegia. ( 15795209 )
2005
45
Muscle force generation and force control of finger movements in children with spastic hemiplegia during isometric tasks. ( 15892376 )
2005
46
Novel approach for spastic hemiplegia classification through the use of support vector machines. ( 17271714 )
2004
47
Surgical management of the hand in infantile spastic hemiplegia. ( 14596553 )
2003
48
Intrathecal baclofen in subjects with spastic hemiplegia: assessment of the antispastic effect during gait. ( 12736875 )
2003
49
Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study. ( 12917859 )
2003
50
Stair locomotion in children with spastic hemiplegia: the impact of three different ankle foot orthosis (AFOs) configurations. ( 12297258 )
2002

Variations for Spastic Hemiplegia

Expression for Spastic Hemiplegia

Search GEO for disease gene expression data for Spastic Hemiplegia.

Pathways for Spastic Hemiplegia

GO Terms for Spastic Hemiplegia

Biological processes related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.02 CAPN15 GAS7 SIX3 TDG TFCP2

Molecular functions related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 8.92 CAPN15 GAS7 SIX3 TFCP2

Sources for Spastic Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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