Aliases & Classifications for Spastic Paraparesis

MalaCards integrated aliases for Spastic Paraparesis:

Name: Spastic Paraparesis 49 28

Classifications:



Summaries for Spastic Paraparesis

MalaCards based summary : Spastic Paraparesis is related to spastic paraplegia 35, autosomal recessive and spastic paraplegia 20, autosomal recessive. An important gene associated with Spastic Paraparesis is SPAST (Spastin). The drugs Valproic Acid and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain.

Related Diseases for Spastic Paraparesis

Diseases related to Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 spastic paraplegia 35, autosomal recessive 32.9 FA2H SPG11
2 spastic paraplegia 20, autosomal recessive 32.6 SPAST SPG11
3 hereditary spastic paraplegia 32.4 DDHD1 FA2H SPAST SPG11
4 spastic paraplegia 15, autosomal recessive 31.7 FA2H SPG11 TECPR2
5 spasticity 31.6 DDHD1 TECPR2
6 masa syndrome 31.6 SPAST SPG11
7 spastic paraplegia 3, autosomal dominant 31.4 SPAST SPG11
8 spastic paraplegia 4, autosomal dominant 30.3 SPAST SPG11
9 paraplegia 29.6 DDHD1 FA2H SPAST SPG11
10 tropical spastic paraparesis 12.6
11 htlv-1 associated myelopathy/tropical spastic paraparesis 12.4
12 spastic paraparesis and deafness 12.2
13 myelopathy, htlv-1-associated 12.2
14 branchial myoclonus with spastic paraparesis and cerebellar ataxia 12.0
15 wells-jankovic syndrome 11.9
16 spastic paraplegia 23 11.6
17 spastic paraplegia 2, x-linked 11.6
18 spastic paraplegia 9 11.5
19 alzheimer disease 3 11.4
20 spastic paraplegia 9a, autosomal dominant 11.4
21 human t-cell leukemia virus type 1 11.3
22 retrovirus-associated myelopathy 11.1
23 sjogren-larsson syndrome 11.0
24 peroxisome biogenesis disorder 10b 11.0
25 familial spastic paralysis 11.0
26 pelizaeus-merzbacher-like disease 11.0
27 spastic ataxia 4, autosomal recessive 11.0
28 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 11.0
29 krabbe disease 11.0
30 spastic paraplegia 53, autosomal recessive 11.0
31 mast syndrome 11.0
32 leukemia 10.6
33 t-cell leukemia 10.6
34 alzheimer disease 10.5
35 ataxia and polyneuropathy, adult-onset 10.3
36 adult t-cell leukemia 10.3
37 neuropathy 10.3
38 multiple sclerosis 10.3
39 dermatitis 10.3
40 spastic paraplegia 52, autosomal recessive 10.3 DDHD1 VPS37A
41 lymphoma 10.3
42 spastic paraplegia 50, autosomal recessive 10.2 DDHD1 VPS37A
43 hepatitis 10.2
44 cerebritis 10.2
45 neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive 10.1 SPAST SPG11
46 aging 10.1
47 dementia 10.1
48 adrenomyeloneuropathy 10.1
49 spastic paraplegia 49, autosomal recessive 10.1 SPG11 TECPR2
50 spastic paraplegia 11, autosomal recessive 10.1

Graphical network of the top 20 diseases related to Spastic Paraparesis:



Diseases related to Spastic Paraparesis

Symptoms & Phenotypes for Spastic Paraparesis

Drugs & Therapeutics for Spastic Paraparesis

Drugs for Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4 Central Nervous System Depressants Phase 3
5 GABA Agents Phase 3
6 Neurotransmitter Agents Phase 3
7 Tranquilizing Agents Phase 3
8 Cyclosporins Phase 2, Phase 3
9 Vasodilator Agents Phase 3
10 Dermatologic Agents Phase 2, Phase 3
11 Anticonvulsants Phase 3
12 Phosphodiesterase Inhibitors Phase 3
13 Anti-Infective Agents Phase 2, Phase 3,Early Phase 1
14 Antifungal Agents Phase 2, Phase 3
15 Platelet Aggregation Inhibitors Phase 3
16 Antimanic Agents Phase 3
17 Immunosuppressive Agents Phase 2, Phase 3
18 Protective Agents Phase 3,Phase 2
19 Psychotropic Drugs Phase 3
20 Radiation-Protective Agents Phase 3
21 Antioxidants Phase 3,Phase 2
22 Antirheumatic Agents Phase 2, Phase 3
23 Calcineurin Inhibitors Phase 2, Phase 3
24
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
25
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
26
Infliximab Approved Phase 2 170277-31-3
27 Tocopherol Approved, Investigational, Nutraceutical Phase 2
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
29
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
30 interferons Phase 2
31 Respiratory System Agents Phase 2
32 Adjuvants, Immunologic Phase 2
33 Micronutrients Phase 2
34 N-monoacetylcystine Phase 2
35 Thioctic Acid Phase 2
36 Tocopherols Phase 2
37 Tocotrienols Phase 2
38 Trace Elements Phase 2
39 Vitamin B Complex Phase 2
40 Vitamins Phase 2
41 Antidotes Phase 2
42 Expectorants Phase 2
43 Interferon-beta Phase 2
44 Antiviral Agents Phase 2,Early Phase 1
45 Gastrointestinal Agents Phase 2
46 Folate Nutraceutical Phase 2
47 Tocotrienol Investigational, Nutraceutical Phase 2 6829-55-6
48 Alpha-lipoic Acid Nutraceutical Phase 2
49 Vitamin B9 Nutraceutical Phase 2
50 Antibodies, Monoclonal Phase 1

Interventional clinical trials:

(show all 20)

# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
2 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
4 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
5 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
6 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
7 A Clinical Trial for AMN: Validation of Biomarkers of Oxidative Stress, Efficacy and Safety of a Mixture of Antioxidants Completed NCT01495260 Phase 2 N-acetylcysteine;lipoic acid;vitamin E
8 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
9 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
10 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819
11 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Unknown status NCT01754311
12 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
13 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
14 Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) Completed NCT00677768
15 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
16 Physiologic Studies of Spasticity Completed NCT00014976
17 Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis Completed NCT00023075
18 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Recruiting NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
19 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
20 Raltegravir for HAM/TSP Active, not recruiting NCT01867320 Early Phase 1 Raltegravir

Search NIH Clinical Center for Spastic Paraparesis

Genetic Tests for Spastic Paraparesis

Genetic tests related to Spastic Paraparesis:

# Genetic test Affiliating Genes
1 Spastic Paraparesis 28

Anatomical Context for Spastic Paraparesis

MalaCards organs/tissues related to Spastic Paraparesis:

38
T Cells, Spinal Cord, Brain, Nk Cells, B Cells, Testes, Amygdala

Publications for Spastic Paraparesis

Articles related to Spastic Paraparesis:

(show top 50) (show all 700)
# Title Authors Year
1
Spastic paraparesis and sensorineural hearing loss: keep brucellosis in mind. ( 29406895 )
2018
2
Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 )
2018
3
Spastic paraparesis with basal ganglia changes: Infantile neuroaxonal dystrophy. ( 29323006 )
2018
4
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
5
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
6
Serial Casting as an Adjunct to Botulinum Toxin Type A Treatment in Children With Cerebral Palsy and Spastic Paraparesis With Scissoring of the Lower Extremities. ( 28393669 )
2017
7
The novel PSEN1 M84V mutation associated to frontal dysexecutive syndrome, spastic paraparesis, and cerebellar atrophy in a dominant Alzheimer's disease family. ( 28532646 )
2017
8
Increased lower limb muscle coactivation reduces gait performance and increases metabolic cost in patients with hereditary spastic paraparesis. ( 28779695 )
2017
9
Compound heterozygosity in the GALC gene in a late onset Iranian patient with spastic paraparesis, peripheral neuropathy and leukoencephalopathy. ( 28547031 )
2017
10
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
11
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia. ( 28343405 )
2017
12
Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23. ( 28157540 )
2017
13
Adrenomyeloneuropathy due to mutation in the ABCD1 gene as underlying factor in spastic paraparesis. ( 29243459 )
2017
14
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-I^, and TNF-I+ in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
15
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
16
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
17
An epidemic of spastic paraparesis of unknown aetiology in Northern Mozambique. ( 28721170 )
2017
18
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
19
A Middle-aged Man With Progressive Ophthalmoparesis, Ataxia, and Spastic Paraparesis. ( 28437518 )
2017
20
<i>TRMT5</i> mutations are associated with features of complex hereditary spastic paraparesis. ( 29021354 )
2017
21
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
22
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. ( 28536850 )
2017
23
Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) with a novel DARS2 mutation and isolated progressive spastic paraparesis. ( 28017220 )
2017
24
Novel c.775_781dup,p(Thr261fs) mutation in SPG 7 gene in a patient with hereditary spastic paraparesis. ( 28879915 )
2017
25
Oculodentodigital Dysplasia Presenting as Spastic Paraparesis: The First Genetically Confirmed Korean Case and a Literature Review. ( 28950687 )
2017
26
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 29292042 )
2017
27
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
28
Case series of autosomal recessive hereditary spastic paraparesis with novel mutation in SPG 7 gene. ( 29057857 )
2017
29
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
30
Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. ( 28380116 )
2017
31
IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28410448 )
2017
32
Effects of superficial heating and insulation on walking speed in people with hereditary and spontaneous spastic paraparesis: A randomised crossover study. ( 29241713 )
2017
33
Immune-mediated spastic paraparesis accompanied with high titres of voltage-gated potassium channel complex antibodies and myokymia/fasciculation. ( 27084231 )
2016
34
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
35
Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. ( 27614114 )
2016
36
Health survey of adults with hereditary spastic paraparesis compared to population study controls. ( 27412159 )
2016
37
Longstanding spastic paraparesis in a patient infected with hepatitis C virus and seropositive for aquaporin-4 antibody - Case report and review of the literature. ( 27456886 )
2016
38
Episodic spastic paraparesis successfully treated with unaided blood transfusions: a case report. ( 26915434 )
2016
39
Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. ( 26890779 )
2016
40
Mitochondrial dysfunction in hereditary spastic paraparesis with mutations in DDHD1/SPG28. ( 26944165 )
2016
41
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
42
Cerebellar dysfunction and spastic paraparesis associated to anti-Ri antibodies in a patient with a pancreatic neuroendocrine tumor. ( 27591774 )
2016
43
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2016
44
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
45
Gait Patterns in Patients with Hereditary Spastic Paraparesis. ( 27732632 )
2016
46
Multiple system atrophy presenting initially as spastic paraparesis. ( 26723996 )
2016
47
The Effects of Dalfampridine on Hereditary Spastic Paraparesis. ( 27606838 )
2016
48
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
49
Superficial warming and cooling of the leg affects walking speed and neuromuscular impairments in people with spastic paraparesis. ( 27262978 )
2016
50
Selective dorsal rhizotomy for hereditary spastic paraparesis in children. ( 27312078 )
2016

Variations for Spastic Paraparesis

ClinVar genetic disease variations for Spastic Paraparesis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 AAAS NM_015665.5(AAAS): c.787T> C (p.Ser263Pro) single nucleotide variant Pathogenic/Likely pathogenic rs121918550 GRCh37 Chromosome 12, 53703408: 53703408
2 SPAST NM_014946.3(SPAST): c.1495C> T (p.Arg499Cys) single nucleotide variant Pathogenic rs121908511 GRCh37 Chromosome 2, 32366974: 32366974

Expression for Spastic Paraparesis

Search GEO for disease gene expression data for Spastic Paraparesis.

Pathways for Spastic Paraparesis

GO Terms for Spastic Paraparesis

Biological processes related to Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial transport GO:0006839 8.62 PSEN1 SLC25A15

Sources for Spastic Paraparesis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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