MCID: SPS019
MIFTS: 41

Spastic Paraparesis malady

Rare diseases category
Download this MalaCard

Summaries for Spastic Paraparesis

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Spastic Paraparesis is related to tropical spastic paraparesis and alzheimer's disease. An important gene associated with Spastic Paraparesis is FA2H (fatty acid 2-hydroxylase), and among its related pathways are Cytoplasmic microtubules and Amyotrophic lateral sclerosis (ALS). The compounds superoxide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related mouse phenotypes are normal and behavior/neurological.

Aliases & Classifications for Spastic Paraparesis

About this section
Sources:
43NIH Rare Diseases
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

spastic paraparesis 43


Related Diseases for Spastic Paraparesis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spastic Paraparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1tropical spastic paraparesis32.2CNTN2
2alzheimer's disease31.0PSEN1, NEFH, NEFL
3neuropathy30.8NEFH, NEFL
4multiple sclerosis30.7CD274, KLRK1, CX3CR1, NEFL
5amyotrophic lateral sclerosis30.5NEFL, NEFH, PSEN1
6systemic lupus erythematosus30.0KLRK1, CX3CR1, TNFRSF4
7spasticity11.5
8leukemia10.8
9t-cell leukemia10.8
10htlv-1 associated myelopathy/tropical spastic paraparesis10.8
11htlv-1 associated myelopathy10.8
12adult t-cell leukemia10.6
13ataxia10.6
14dermatitis10.6
15hereditary spastic paraplegia10.5
16hepatitis10.5
17cerebritis10.4
18dementia10.4
19peripheral neuropathy10.4
20lateral sclerosis10.4
21neurologic diseases10.4
22adrenomyeloneuropathy10.4
23human t-cell leukemia virus type 110.4
24leukodystrophy, dysmyelinating, and spastic paraparesis with or without dystonia10.4
25wells-jankovic syndrome10.4
26retrovirus-associated myelopathy10.4
27myelitis10.3
28adrenoleukodystrophy10.3
29creutzfeldt-jakob disease10.3
30ischemia10.3
31leukodystrophy10.3
32paraplegia10.3
33troyer syndrome10.3
34infective dermatitis associated with htlv-110.3
35lyme disease10.2
36addison's disease10.2
37sensorineural hearing loss10.2
38cataract10.2
39cerebellar ataxia10.2
40hydrocephalus10.2
41lupus erythematosus10.2
42vasculitis10.2
43fatty acid hydroxylase-associated neurodegeneration10.2
44hyperekplexia10.2
45polymyositis10.2
46spastic paraplegia 1510.2
47spastic paraplegia 910.2
48mental retardation10.2
49autonomic dysfunction10.2
50familial spastic paralysis10.2

Graphical network of the top 20 diseases related to Spastic Paraparesis:



Diseases related to spastic paraparesis

Symptoms for Spastic Paraparesis

About this section

Drugs & Therapeutics for Spastic Paraparesis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Spastic Paraparesis

Search NIH Clinical Center for Spastic Paraparesis

Genetic Tests for Spastic Paraparesis

About this section

Anatomical Context for Spastic Paraparesis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Spastic Paraparesis:

33
T cells, Spinal cord, Brain, Nk cells, Testes, Thymus, B cells, Thyroid, Kidney, Skeletal muscle, Amygdala

Animal Models for Spastic Paraparesis or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Spastic Paraparesis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6PSEN1, CX3CR1, NEFL, TNFRSF4
2MP:00053867.9CD274, CNTN2, PSEN1, CX3CR1, FA2H, NEFH
3MP:00053847.9TNFRSF4, NEFH, CX3CR1, PSEN1, CD274
4MP:00036317.9NEFL, NEFH, FA2H, CX3CR1, PSEN1, CNTN2
5MP:00053977.8TNFRSF4, CX3CR1, PSEN1, KLRK1, CD274
6MP:00053877.7CD274, KLRK1, PSEN1, CX3CR1, TNFRSF4

Publications for Spastic Paraparesis

About this section
Sources:
52PubMed
See all sources

Articles related to Spastic Paraparesis:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
2
Use of intrathecal clonidine in patients with multiple sclerosis or spastic paraparesis. (22057402)
2012
3
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
4
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. (22300227)
2011
5
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
6
Amygdala size reduction is associated with memory deficits in complicated hereditary spastic paraparesis: an MRI study. (20664204)
2010
7
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
8
Presence of tropical spastic paraparesis/human T-cell lymphotropic virus type 1-associated myelopathy (TSP/HAM)-like among HIV-1-infected patients. (18205234)
2008
9
Low risk of tropical spastic paraparesis/human T lymphotropic virus type 1-associated myelopathy development among persons aged >50 years. (18680397)
2008
10
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
11
Abnormal corticospinal tract modulation of the soleus H reflex in patients with pure spastic paraparesis. (18434014)
2008
12
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
13
Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)
2005
14
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
15
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)
2004
16
Pure spastic paraparesis associated with a novel presenilin 1 R278K mutation. (12525746)
2003
17
Cyclosporine-induced reversible pure motor spastic paraparesis in a patient with aplastic anaemia. (12568232)
2002
18
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
19
Friedreich's ataxia presenting as an isolated spastic paraparesis. (11688498)
2001
20
Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation. (11148263)
2001
21
Tropical spastic paraparesis. (11928898)
2001
22
Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis. (11015453)
2000
23
Hereditary spastic paraparesis: a review of new developments. (10896685)
2000
24
Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets. (10967179)
2000
25
Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. (10491011)
1999
26
On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. (10460931)
1999
27
Spastic paraparesis in alcoholic cirrhosis with portal systemic encephalopathy. (11273332)
1998
28
A case of Machado-Joseph disease presenting with spastic paraparesis. (9153623)
1997
29
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
30
The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. (8627062)
1996
31
Nucleotide sequences of human T-lymphotropic virus type I (HTLV-I) from a family cluster with tropical spastic paraparesis/HTLV-I-associated myelopathy. (7638441)
1995
32
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives. (8563108)
1995
33
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7756498)
1995
34
Tropical spastic paraparesis/HTLV-I associated myelopathy. Etiology and clinical spectrum. (7999314)
1994
35
HTLV-1 infection and tropical spastic paraparesis in Esmeraldas Province of Ecuador. (7570816)
1994
36
Urinary dysfunction in tropical spastic paraparesis: preliminary urodynamic survey. (8345613)
1993
37
Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. (8213080)
1993
38
Spastic paraparesis of obscure origin. A case-control study of HTLV-I positive and negative patients from Rio de Janeiro, Brazil. (8336163)
1993
39
Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. (1374983)
1992
40
Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. (1520534)
1992
41
Spastic paraparesis associated with portal-systemic venous shunting due to congenital hepatic fibrosis. (1579253)
1992
42
Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis and an asymptomatic carrier to rabbits. (1712582)
1991
43
Neopterin in cerebrospinal fluid: a useful marker for diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis. (2006023)
1991
44
Tropical spastic paraparesis and HTLV-I myelopathy: clinical features and pathogenesis. (2183307)
1990
45
High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. (1967218)
1990
46
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
47
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1. (2536259)
1989
48
HTLV-1 associated tropical spastic paraparesis in an African patient residing in Belgium. (2730175)
1989
49
Tropical spastic paraparesis: lack of human T-lymphotropic virus type I antibodies in blood donors from Bogota, Colombia. (2829802)
1988
50
Tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from Martinique. (2894805)
1988

Variations for Spastic Paraparesis

About this section

Expression for genes affiliated with Spastic Paraparesis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spastic Paraparesis

Search GEO for disease gene expression data for Spastic Paraparesis.

Pathways for genes affiliated with Spastic Paraparesis

About this section
Sources:
50PathCards, 12EMD Millipore, 60Thomson Reuters, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 5Cell Signaling Technology
See all sources

Pathways related to Spastic Paraparesis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.5NEFH, NEFL
2
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.5NEFH, NEFL
39.2PSEN1, NEFH, NEFL

Compounds for genes affiliated with Spastic Paraparesis

About this section
Sources:
45Novoseek, 24HMDB
See all sources

Compounds related to Spastic Paraparesis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1superoxide45 2410.2PSEN1, NEFH, NEFL
2ionomycin458.8CD274, CNTN2, PSEN1, TNFRSF4
3oxygen45 249.1CX3CR1, PSEN1, CNTN2, KLRK1
4retinoic acid45 249.0KLRK1, CNTN2, PSEN1, NEFL

GO Terms for genes affiliated with Spastic Paraparesis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurofilamentGO:0058839.5NEFH, NEFL
2cell surfaceGO:0099869.3CNTN2, PSEN1, TNFRSF4
3axonGO:0304249.1PSEN1, NEFH, NEFL
4integral component of plasma membraneGO:0058878.4TNFRSF4, CX3CR1, PSEN1, CNTN2

Biological processes related to Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:0017649.7CNTN2, PSEN1
2neurofilament bundle assemblyGO:0336939.6NEFH, NEFL
3microtubule cytoskeleton organizationGO:0002269.5NEFH, CNTN2
4cerebral cortex cell migrationGO:0217959.5PSEN1, CX3CR1
5cellular defense responseGO:0069689.2CX3CR1, TNFRSF4

Molecular functions related to Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5NEFH, NEFL
2protein binding, bridgingGO:0306749.2NEFH, NEFL

Products for genes affiliated with Spastic Paraparesis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spastic Paraparesis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet