MCID: SPS019
MIFTS: 35

Spastic Paraparesis malady

Rare diseases category

Summaries for Spastic Paraparesis

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MalaCards based summary: Spastic Paraparesis is related to tropical spastic paraparesis and neuropathy. An important gene associated with Spastic Paraparesis is FA2H (fatty acid 2-hydroxylase), and among its related pathways are Cytoplasmic microtubules and Amyotrophic lateral sclerosis (ALS). The compounds superoxide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related mouse phenotypes are normal and behavior/neurological.

Aliases & Classifications for Spastic Paraparesis

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Spastic Paraparesis, Aliases & Descriptions:

Name: Spastic Paraparesis 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Spastic Paraparesis

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Graphical network of the top 20 diseases related to Spastic Paraparesis:



Diseases related to spastic paraparesis

Symptoms for Spastic Paraparesis

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Drugs & Therapeutics for Spastic Paraparesis

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Drug clinical trials:

Search ClinicalTrials for Spastic Paraparesis

Search NIH Clinical Center for Spastic Paraparesis

Genetic Tests for Spastic Paraparesis

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Anatomical Context for Spastic Paraparesis

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MalaCards organs/tissues related to Spastic Paraparesis:

31
T cells, Spinal cord, Brain, Testes, Nk cells, B cells, Thymus, Skeletal muscle, Kidney, Thyroid, Amygdala

Animal Models for Spastic Paraparesis or affiliated genes

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MGI Mouse Phenotypes related to Spastic Paraparesis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6PSEN1, CX3CR1, NEFL, TNFRSF4
2MP:00053867.9CD274, CNTN2, PSEN1, CX3CR1, FA2H, NEFH
3MP:00053847.9TNFRSF4, NEFH, CX3CR1, PSEN1, CD274
4MP:00036317.9NEFL, NEFH, FA2H, CX3CR1, PSEN1, CNTN2
5MP:00053977.8TNFRSF4, CX3CR1, PSEN1, KLRK1, CD274
6MP:00053877.7CD274, KLRK1, PSEN1, CX3CR1, TNFRSF4

Publications for Spastic Paraparesis

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Articles related to Spastic Paraparesis:

(show top 50)    (show all 629)
idTitleAuthorsYear
1
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. (25229227)
2014
2
Leukodystrophies underlying cryptic spastic paraparesis: frequency and phenotype in 76 patients. (24698313)
2014
3
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
4
Use of intrathecal clonidine in patients with multiple sclerosis or spastic paraparesis. (22057402)
2012
5
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. (22170554)
2012
6
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. (22300227)
2011
7
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
8
Amygdala size reduction is associated with memory deficits in complicated hereditary spastic paraparesis: an MRI study. (20664204)
2010
9
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
10
Presence of tropical spastic paraparesis/human T-cell lymphotropic virus type 1-associated myelopathy (TSP/HAM)-like among HIV-1-infected patients. (18205234)
2008
11
Low risk of tropical spastic paraparesis/human T lymphotropic virus type 1-associated myelopathy development among persons aged >50 years. (18680397)
2008
12
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
13
Abnormal corticospinal tract modulation of the soleus H reflex in patients with pure spastic paraparesis. (18434014)
2008
14
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
15
Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)
2005
16
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
17
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)
2004
18
Cyclosporine-induced reversible pure motor spastic paraparesis in a patient with aplastic anaemia. (12568232)
2002
19
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
20
Friedreich's ataxia presenting as an isolated spastic paraparesis. (11688498)
2001
21
Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation. (11148263)
2001
22
Tropical spastic paraparesis. (11928898)
2001
23
Mutation analysis of the spastin gene (SPG4) in patients with hereditary spastic paraparesis. (11015453)
2000
24
Hereditary spastic paraparesis: a review of new developments. (10896685)
2000
25
Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. (10491011)
1999
26
On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. (10460931)
1999
27
Spastic paraparesis in alcoholic cirrhosis with portal systemic encephalopathy. (11273332)
1998
28
A case of Machado-Joseph disease presenting with spastic paraparesis. (9153623)
1997
29
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
30
The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. (8627062)
1996
31
Nucleotide sequences of human T-lymphotropic virus type I (HTLV-I) from a family cluster with tropical spastic paraparesis/HTLV-I-associated myelopathy. (7638441)
1995
32
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP): recent perspectives. (8563108)
1995
33
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7756498)
1995
34
Tropical spastic paraparesis/HTLV-I associated myelopathy. Etiology and clinical spectrum. (7999314)
1994
35
HTLV-1 infection and tropical spastic paraparesis in Esmeraldas Province of Ecuador. (7570816)
1994
36
Urinary dysfunction in tropical spastic paraparesis: preliminary urodynamic survey. (8345613)
1993
37
Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. (8213080)
1993
38
Spastic paraparesis of obscure origin. A case-control study of HTLV-I positive and negative patients from Rio de Janeiro, Brazil. (8336163)
1993
39
Activated, HTLV-1-specific cytotoxic T-lymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. (1374983)
1992
40
Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. (1520534)
1992
41
Spastic paraparesis associated with portal-systemic venous shunting due to congenital hepatic fibrosis. (1579253)
1992
42
Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis and an asymptomatic carrier to rabbits. (1712582)
1991
43
Neopterin in cerebrospinal fluid: a useful marker for diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis. (2006023)
1991
44
Tropical spastic paraparesis and HTLV-I myelopathy: clinical features and pathogenesis. (2183307)
1990
45
High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. (1967218)
1990
46
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
47
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1. (2536259)
1989
48
HTLV-1 associated tropical spastic paraparesis in an African patient residing in Belgium. (2730175)
1989
49
Tropical spastic paraparesis: lack of human T-lymphotropic virus type I antibodies in blood donors from Bogota, Colombia. (2829802)
1988
50
Tropical spastic paraparesis: clinical, immunological, and virological studies in two patients from Martinique. (2894805)
1988

Variations for Spastic Paraparesis

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Expression for genes affiliated with Spastic Paraparesis

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Search GEO for disease gene expression data for Spastic Paraparesis.

Pathways for genes affiliated with Spastic Paraparesis

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Pathways related to Spastic Paraparesis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.5NEFH, NEFL
29.2PSEN1, NEFH, NEFL

Compounds for genes affiliated with Spastic Paraparesis

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Sources:
43Novoseek, 24HMDB
See all sources

Compounds related to Spastic Paraparesis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1superoxide43 2410.2PSEN1, NEFH, NEFL
2ionomycin438.8CD274, CNTN2, PSEN1, TNFRSF4
3oxygen43 249.1CX3CR1, PSEN1, CNTN2, KLRK1
4retinoic acid43 249.0KLRK1, CNTN2, PSEN1, NEFL

GO Terms for genes affiliated with Spastic Paraparesis

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Cellular components related to Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neurofilamentGO:00058839.5NEFH, NEFL
2cell surfaceGO:00099869.3CNTN2, PSEN1, TNFRSF4
3axonGO:00304249.1PSEN1, NEFH, NEFL
4integral component of plasma membraneGO:00058878.4TNFRSF4, CX3CR1, PSEN1, CNTN2

Biological processes related to Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron migrationGO:00017649.7CNTN2, PSEN1
2neurofilament bundle assemblyGO:00336939.6NEFH, NEFL
3microtubule cytoskeleton organizationGO:00002269.5NEFH, CNTN2
4cerebral cortex cell migrationGO:00217959.5PSEN1, CX3CR1
5cellular defense responseGO:00069689.2CX3CR1, TNFRSF4

Molecular functions related to Spastic Paraparesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.5NEFH, NEFL
2protein binding, bridgingGO:00306749.2NEFH, NEFL

Products for genes affiliated with Spastic Paraparesis

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Spastic Paraparesis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet