MCID: SPS019
MIFTS: 35

Spastic Paraparesis malady

Summaries for Spastic Paraparesis

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Spastic Paraparesis is related to tropical spastic paraparesis and leukemia. An important gene associated with Spastic Paraparesis is FA2H (fatty acid 2-hydroxylase), and among its related pathways are Notch Pathway and Apoptosis Pathway. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Spastic Paraparesis

About this section
Sources:
42NIH Rare Diseases
See all sources

Aliases & Descriptions:

spastic paraparesis 42


Related Diseases for Spastic Paraparesis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spastic Paraparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1tropical spastic paraparesis32.0MBP, FASLG, IL2RA, IL2
2leukemia31.2KLRK1, JUN, MBP, FASLG, HLA-A, NFKB1
3t-cell leukemia31.2JUN, FASLG, NFKB1, MYC, IL2RA, IL2
4alzheimer's disease31.0RPS27A, JUN, PSEN1
5multiple sclerosis30.8HLA-A, VDR, CD274, CX3CR1, IL2RA, IL2
6dermatitis30.8CX3CR1
7neuropathy30.8MBP
8hepatitis30.6HLA-A, FASLG
9dementia30.6RPS27A, PSEN1
10ischemia30.4PSEN1
11amyotrophic lateral sclerosis30.4RPS27A, PSEN1
12vasculitis30.3NFKB1
13thyroiditis30.0FASLG
14myositis30.0PSEN1, RPS27A
15sarcoma30.0IL2, VDR
16acute leukemia30.0IL2
17psoriasis30.0HLA-A, VDR, CX3CR1, IL2RA, IL2, KIR2DS1
18synovitis30.0CX3CR1
19systemic lupus erythematosus30.0KLRK1, RPS27A, PDCD1, FASLG, HLA-A, CX3CR1
20prion disease30.0PSEN1, MBP, JUN
21adult t-cell leukemia10.6
22htlv-1 associated myelopathy/tropical spastic paraparesis10.5
23cerebritis10.4
24hereditary spastic paraplegia10.4
25peripheral neuropathy10.4
26lateral sclerosis10.3
27neurologic diseases10.3
28wells-jankovic syndrome10.3
29leukodystrophy, dysmyelinating, and spastic paraparesis with or without dystonia10.3
30htlv-1 associated myelopathy10.3
31retrovirus-associated myelopathy10.3
32myelitis10.3
33adrenoleukodystrophy10.3
34adult lymphoma10.3
35leukodystrophy10.3
36paraplegia10.3
37spinal cord disease10.3
38spinal cord ischemia10.3
39sensorineural hearing loss10.2
40lyme disease10.2
41addison's disease10.2
42cataract10.2
43cerebellar ataxia10.2
44hydrocephalus10.2
45lupus erythematosus10.2
46fatty acid hydroxylase-associated neurodegeneration10.2
47hereditary ataxia10.2
48hyperekplexia10.2
49troyer syndrome10.2
50spastic paraplegia 910.2

Graphical network of the top 20 diseases related to Spastic Paraparesis:



Diseases related to spastic paraparesis

Clinical Features for Spastic Paraparesis

About this section

Drugs & Therapeutics for Spastic Paraparesis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Spastic Paraparesis

Drug clinical trials:

Search ClinicalTrials for Spastic Paraparesis

Search NIH Clinical Center for Spastic Paraparesis

Search CenterWatch for Spastic Paraparesis

Genetic Tests for Spastic Paraparesis

About this section

Anatomical Context for Spastic Paraparesis

About this section

Animal Models for Spastic Paraparesis or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Spastic Paraparesis

About this section

Genetic Variations for Spastic Paraparesis

About this section

Expression for genes affiliated with Spastic Paraparesis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spastic Paraparesis

Search GEO for disease gene expression data for Spastic Paraparesis.

Pathways for genes affiliated with Spastic Paraparesis

About this section
Sources:
59Tocris Bioscience, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN, 49PharmGKB, 29KEGG
See all sources

Pathways related to Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MYC, PSEN1
2
Hide members
10.4IL2RA, JUN
3
Hide members
10.4IL2, IL2RA, FASLG
410.4JUN, PSEN1, MYC
5
Hide members
10.4FASLG, MYC, NFKB1
610.4NFKB1, MYC, IL2RA
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.4JUN, VDR, FASLG
8
Hide members
10.4NFKB1, JUN, RPS27A
910.4JUN, IL2RA, IL2
1010.4VDR, JUN, MYC
1110.4NFKB1, JUN, MYC
12
Hide members
10.4JUN, NFKB1, MYC
13
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
Hide members
10.4JUN, MYC, NFKB1
1410.4JUN, IL2, NFKB1
1510.4JUN, IL2, NFKB1
16
Apoptosis and survival Lymphotoxin-beta receptor signaling
Hide members
10.4NFKB1, JUN, IL2
1710.4JUN, NFKB1, IL2
1810.4IL2, NFKB1, JUN
19
Hide members
10.4NFKB1, HLA-A, RPS27A, KLRK1
20
Hide members
10.4RPS27A, IL2, IL2RA, NFKB1
21
Hide members
10.4JUN, IL2RA, FASLG, IL2
22
Hide members
10.4MYC, NFKB1, FASLG, JUN
2310.4MYC, FASLG, JUN, NFKB1
24
Hide members
10.4JUN, NFKB1, FASLG, MYC
25
Hide members
10.4NFKB1, JUN, FASLG, MYC
26
Hide members
10.4NFKB1, PDCD1, JUN, IL2
2710.4IL2, JUN, MYC, IL2RA
28
Hide members
10.4JUN, MYC, IL2RA, IL2
2910.4MYC, JUN, NFKB1, HLA-A
30
Hide members
10.4NFKB1, IL2, JUN, IL2RA
31
Hide members
10.4IL2RA, JUN, NFKB1, IL2
32
Hide members
10.4MYC, CX3CR1, NFKB1, IL2RA, FASLG
3310.4JUN, NFKB1, MYC, IL2
34
Hide members
10.4CX3CR1, MYC, PSEN1, JUN, NFKB1
35
Hide members
10.4FASLG, JUN, MYC, NFKB1, PSEN1
36
Hide members
10.4IL2RA, NFKB1, IL2, RPS27A, HLA-A
37
Hide members
10.4IL2RA, FASLG, IL2, NFKB1, MYC
3810.4FASLG, NFKB1, MYC, IL2RA, IL2
3910.4JUN, IL2RA, HLA-A, FASLG, IL2
40
Hide members
10.3IL2, MYC, FASLG, JUN, NFKB1
41
Immune response IL-2 activation and signaling pathway
Hide members
10.3IL2, IL2RA, MYC, NFKB1, JUN
42
Hide members
10.3IL2, IL2RA, MYC, NFKB1, JUN
43
Hide members
10.3JUN, IL2, PSEN1, IL2RA, MYC, NFKB1
44
Hide members
10.3HLA-A, NFKB1, IL2, FASLG, IL2RA, JUN
45
Hide members
10.3FASLG, HLA-A, NFKB1, IL2, JUN, IL2RA
4610.3JUN, IL2, IL2RA, HLA-A, MYC, NFKB1
47
Hide members
10.3KIR2DS2, KIR2DS5, IL2, KIR2DL5A, KIR2DS1
48
Hide members
10.3KIR2DS2, KIR2DS1, KIR2DS5, KLRK1, RPS27A, NFKB1
49
Hide members
10.3NFKB1, HLA-A, CD274, PDCD1, KLRK1, JUN
50
Hide members
10.2KIR2DS1, KIR2DS2, KIR2DL5A, IL2, NFKB1, HLA-A

Compounds for genes affiliated with Spastic Paraparesis

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9PSEN1, FASLG
2indomethacin44 59 28 1113.8MBP, RPS27A
3pge24410.8IL2
4c-d4t4410.8FASLG, IL2, IL2RA
5arsenite44 2411.8VDR, FASLG, RPS27A
6dexamethasone44 49 28 1113.8MYC, FASLG, VDR, JUN
7sodium arsenite4410.8IL2RA, FASLG, MYC, JUN
8lactacystin4410.8VDR, JUN, RPS27A, FASLG, PSEN1, MYC
9tamoxifen44 49 28 1113.8RPS27A, JUN, VDR, IL2, FASLG
10mg 13244 5911.8VDR, MYC, JUN, RPS27A, FASLG
11propanil4410.8IL2, MYC, RPS27A
12ionomycin4410.8FASLG, JUN, IL2RA, CD274, PSEN1, IL2
134-hydroxytamoxifen4410.8MYC, FASLG, VDR, JUN
14herbimycin a44 5911.8RPS27A, JUN, MYC, IL2RA, IL2
15bortezomib44 1111.8MYC, RPS27A, JUN, FASLG
16tacrolimus44 49 1112.8IL2RA, FASLG, IL2, VDR, MYC, HLA-A
17n acetylcysteine4410.8MBP, RPS27A, MYC, FASLG, JUN, IL2RA
18rapamycin4410.7IL2RA, JUN, FASLG, MYC, IL2, RPS27A
19thalidomide44 49 59 1113.7IL2RA, IL2, NFKB1, FASLG
204-hydroxynonenal44 2411.7PSEN1, RPS27A, JUN, MYC
21calcitriol44 59 11 2413.7MYC, JUN, IL2, VDR, IL2RA
22actinomycin d4410.7JUN, IL2, MYC, VDR, FASLG, RPS27A
235fluorouracil4410.7IL2RA, VDR, HLA-A, FASLG, IL2
24thymidine44 2411.7JUN, IL2, IL2RA, VDR, MYC, FASLG
25anisomycin44 1111.7MYC, FASLG, JUN, IL2RA
26genistein44 28 59 2 11 2415.7JUN, FASLG, IL2RA, MYC, VDR, IL2
27levamisole44 1111.7IL2RA, IL2, HLA-A
28rantes4410.7JUN, FASLG, IL2RA, IL2
29butyrate4410.7RPS27A
30cyclosporin a44 28 5912.7VDR, IL2, HLA-A, RPS27A, JUN, MBP
31retinoic acid44 2411.7RPS27A, JUN, MYC, VDR, KLRK1, PSEN1
32cisplatin44 49 59 1113.7IL2, FASLG, MBP, RPS27A, MYC, IL2RA
33vegf4410.7RPS27A, JUN, FASLG, MYC, CX3CR1, IL2RA
34etoposide44 49 59 1113.6NFKB1, MYC, FASLG, JUN, IL2RA
35tyrosine4410.6JUN, FASLG, RPS27A, PDCD1, KIR2DL5A, IL2
36phosphatidylinositol4410.6FASLG, KLRK1, MYC, CX3CR1, PSEN1, IL2RA
37arginine4410.6HLA-A, PSEN1, IL2RA, VDR, KLRK1, RPS27A
38aspartate4410.6RPS27A, IL2RA, VDR, FASLG, MBP, PSEN1
39estrogen4410.6VDR
40biotin44 11 2412.6IL2, FASLG, RPS27A, PSEN1
41cytarabine44 49 1112.6MYC, FASLG, MBP, JUN
42adenylate4410.6HLA-A, IL2RA, MBP, VDR, RPS27A, FASLG
43alanine4410.6FASLG, MYC, HLA-A, VDR, MBP, PSEN1
44prednisolone44 28 1112.6MYC, IL2RA, MBP
45h2o24410.4IL2RA, MBP, JUN, FASLG, RPS27A, PSEN1
46camptothecin44 59 1112.4MYC, FASLG, JUN, RPS27A
472-chlorodeoxyadenosine4410.4IL2RA, FASLG, IL2
48imatinib44 49 1112.4FASLG, KLRK1, RPS27A, MYC
49cysteine4410.2VDR, RPS27A, FASLG, IL2RA, PSEN1, MBP
50cyclophosphamide44 49 1112.1IL2, IL2RA, FASLG, MBP

GO Terms for genes affiliated with Spastic Paraparesis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4IL2RA, CD274, FASLG, PDCD1
2plasma membraneGO:0058869.9KIR2DS5, RPS27A, PDCD1, MBP, HLA-A, CD274

Biological processes related to Spastic Paraparesis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:04601310.8IL2, IL2RA
2Notch signaling pathwayGO:00721910.7IL2RA, PSEN1, RPS27A, MYC
3cerebral cortex cell migrationGO:02179510.7CX3CR1, PSEN1
4negative regulation of inflammatory responseGO:05072810.7IL2RA, NFKB1, IL2
5toll-like receptor 10 signaling pathwayGO:03416610.7RPS27A, JUN, NFKB1
6negative regulation of apoptotic processGO:04306610.7RPS27A, PSEN1, NFKB1, MYC, CX3CR1, IL2
7toll-like receptor 5 signaling pathwayGO:03414610.7NFKB1, JUN, RPS27A
8negative regulation of transcription from RNA polymerase II promoterGO:00012210.7VDR, FASLG, PSEN1, NFKB1, MYC, RPS27A
9toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.7NFKB1, RPS27A, JUN
10toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.7NFKB1, RPS27A, JUN
11toll-like receptor 9 signaling pathwayGO:03416210.6RPS27A, JUN, NFKB1
12positive regulation of transcription from RNA polymerase II promoterGO:04594410.6IL2, RPS27A, JUN, NFKB1, MYC, VDR
13toll-like receptor 2 signaling pathwayGO:03413410.6RPS27A, JUN, NFKB1
14innate immune responseGO:04508710.6RPS27A, KIR2DS5, KIR2DS1, JUN, NFKB1, KIR2DS2
15TRIF-dependent toll-like receptor signaling pathwayGO:03566610.6NFKB1, JUN, RPS27A
16MyD88-independent toll-like receptor signaling pathwayGO:00275610.6RPS27A, JUN, NFKB1
17immune responseGO:00695510.6IL2RA, IL2, KIR2DS2, KIR2DS1, KIR2DS5, HLA-A
18MyD88-dependent toll-like receptor signaling pathwayGO:00275510.5NFKB1, JUN, RPS27A
19toll-like receptor 3 signaling pathwayGO:03413810.5NFKB1, JUN, RPS27A
20positive regulation of apoptotic processGO:04306510.5IL2RA, RPS27A, FASLG, PSEN1
21response to growth factor stimulusGO:07084810.4FASLG, MYC
22toll-like receptor 4 signaling pathwayGO:03414210.4JUN, RPS27A, NFKB1
23T cell receptor signaling pathwayGO:05085210.3RPS27A, PSEN1, NFKB1
24regulation of immune responseGO:05077610.1HLA-A, KIR2DS2, KIR2DS1

Products for genes affiliated with Spastic Paraparesis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spastic Paraparesis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet