Spastic Paraparesis malady

MalaCards: Spastic Paraparesis is related to tropical spastic paraparesis and htlv-1 associated myelopathy/tropical spastic paraparesis. An important gene associated with Spastic Paraparesis is FA2H (fatty acid 2-hydroxylase), and among its related pathways are OX40 Pathway and IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds pge2 and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

spastic paraparesis 30

Diseases related to spastic paraparesis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 598)

id	Related Disease	Score	Top Affiliating Genes
1	tropical spastic paraparesis	36.8	CNTN2, MMP9, IL15, IL2, IL2RA, IL2RB
2	htlv-1 associated myelopathy/tropical spastic paraparesis	35.6	PDCD1, VDR, MYC, JUN, CD274, IL2
3	htlv-1 associated myelopathy	34.5	PDCD1, CNTN2, VDR, MYC, JUN, CD274
4	hereditary spastic paraplegia	31.9	HSPD1, SPAST, SPG7
5	t-cell leukemia	31.0	CNTN2, MYC, JUN, CD4, CDKN3, IL2
6	multiple sclerosis	29.9	IL2RA, MBP, IFNG, HLA-A, HLA-B, HLA-DQB1
7	adult t-cell leukemia	29.7	KIR2DL1, KIR2DL3, MYC, CD8A, CD4, IL15
8	polymyositis	29.1	CNTN2, VEGFA, JUN, CD8A, CD274, IL15
9	human t-cell leukemia virus type 1	28.8	PDCD1, CNTN2, MYC, JUN, CD274, CDKN3
10	alzheimer's disease	28.4	VEGFA, VDR, MYC, MTHFR, MTPAP, L1CAM
11	leukemia/lymphoma	27.7	PDCD1, CNTN2, VEGFA, MYC, MTHFR, B2M
12	seizures	27.3	BTD, VEGFA, MTHFR, L1CAM, JUN, CDKN3
13	spasticity	25.5	PDCD1, CNTN2, KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3
14	dementia	24.8	VEGFA, MTHFR, B2M, L1CAM, JUN, CD4
15	leukemia	20.4	PDCD1, CNTN2, KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3
16	t-cell large granular lymphocyte leukemia	13.8	CNTN2, IL2, IL2RB, FASLG
17	lumbar disc degeneration	13.8	VDR, IL10, FASLG
18	diffuse infiltrative lymphocytosis syndrome	13.8	B2M, IL2, IL2RA, IL2RB, FASLG
19	postherpetic neuralgia	13.7	HLA-A, HLA-B, HLA-DRB1
20	hematologic cancer	13.7	IL2, IL2RA, IL2RB
21	pick's disease	13.7	MYC, MBP, CCL3, RPS27A, PSEN1, NEFH
22	gamma chain deficiency	13.7	IL15, IL2, IL2RA, IL2RB
23	t-lymphocytopenia	13.7	KIR2DL3, IL2, IL2RB, ANXA5
24	posterior uveitis	13.7	IL2RA, IL2RB, FASLG, IFNG
25	pars planitis	13.7	HLA-A, HLA-B, HLA-DRB1
26	hypersensitivity reaction type iv disease	13.7	IL2, IL2RB, MBP, IFNG
27	autoimmune myocarditis	13.7	CD274, IL12RB1, IL2, IFNG
28	tuberculoid leprosy	13.7	IL10, IL2RA, IFNG
29	periapical granuloma	13.7	IL2, IL2RA, CCL3, IFNG
30	pleural tuberculosis	13.7	IL2RA, CCL3, IFNG
31	autoimmune lymphoproliferative syndrome	13.7	CD4, IL10, IL2RA, FASLG
32	multifocal motor neuropathy	13.7	IL10, IL2, IFNG
33	epidermolysis bullosa acquisita	13.7	SERPINH1, IL2RA, IL2RB, HLA-DRB1
34	coccidiosis	13.7	CD8A, CD4, IL2, IFNG
35	adult glioblastoma multiforme	13.7	HLA-A, HLA-B, HLA-C, HLA-DRB1
36	progressive supranuclear palsy	13.7	VEGFA, MYC, IL2, RPS27A, NEFL
37	thyroid medullary carcinoma	13.7	B2M, JUN, IL2, FASLG, HLA-B
38	lymphatic system disease	13.7	CD8A, CD4, IL2, IFNG
39	eosinophilic meningitis	13.7	MMP9, IL10, IL2
40	immune defect due to absence of thymus	13.6	VDR, IL10, IL12RB1, IL2, IL2RA, IL2RB
41	intermediate uveitis	13.6	IL10, IL2RA, IFNG
42	extramedullary plasmacytoma	13.6	VEGFA, B2M, IL2, IL2RB
43	berylliosis	13.6	IL2, IL2RB, IFNG, HLA-DRB1
44	sezary's disease	13.6	IL15, IL2, IL2RA, IL2RB, IFNG
45	lymphoproliferative syndrome	13.6	IL10, IL2, IL2RA, FASLG
46	campylobacteriosis	13.6	VDR, JUN, IFNG
47	extrinsic allergic alveolitis	13.6	B2M, IL15, IL2RA, IL2RB, CCL3
48	coronary artery aneurysm	13.6	HLA-A, HLA-B, HLA-C, HLA-DRB1
49	listeriosis	13.6	KIR2DS4, CD8A, CD4, IFNG
50	teratocarcinoma	13.6	CNTN2, SERPINH1, MYC, T, JUN, HPRT1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spastic paraparesis:

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MGI Mouse Phenotypes related to spastic paraparesis:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	9.7	PDCD1, BTD, HPRT1, PSEN1
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	HPRT1, ABCD1, FASLG, IL2RB, IL2, MECP2
3	hematopoietic system phenotype	MP:0005397	9.4	PDCD1, CX3CR1, HBZ, PTPN13, HLA-DQB1, HLA-C
4	liver/biliary system phenotype	MP:0005370	9.2	SOD1, VEGFA, IL12RB2, IL2, IFNG, HPRT1
5	digestive/alimentary phenotype	MP:0005381	9.0	GLI2, VEGFA, VDR, MYC, B2M, T
6	immune system phenotype	MP:0005387	9.0	CD4, VDR, BTK, PSEN1, ABCD1, IL2
7	no phenotypic analysis	MP:0003012	8.7	MYC, MTHFR, L1CAM, T, CD4, VEGFA
8	skeleton phenotype	MP:0005390	8.7	GLI2, MECP2, MMP9, JUN, L1CAM, MTHFR
9	normal phenotype	MP:0002873	8.3	SPAST, ABCD1, PSEN1, HLA-DQB1, T, JUN
10	integument phenotype	MP:0010771	8.3	IL2RB, PSEN1, HPRT1, GLI2, MYC, IFNG
11	muscle phenotype	MP:0005369	8.2	BTD, HPRT1, SOD1, CX3CR1, PSEN1, HLA-DQB1
12	cardiovascular system phenotype	MP:0005385	8.0	CX3CR1, SOD1, PSEN1, HLA-DQB1, HPRT1, IFNG
13	reproductive system phenotype	MP:0005389	7.9	VDR, HPRT1, ABCD1, B2M, SPAST, FASLG
14	nervous system phenotype	MP:0003631	7.9	MECP2, FA2H, CD4, CD8A, T, MTHFR
15	vision/eye phenotype	MP:0005391	7.5	MBP, IFNG, GLI2, GLRA1, HPRT1, PTPN13
16	behavior/neurological phenotype	MP:0005386	7.5	CNTN2, NEFH, CD274, MECP2, IL10, IL2
17	growth/size phenotype	MP:0005378	6.7	IL2RA, BTD, BTK, VDR, MTHFR, B2M
18	mortality/aging	MP:0010768	6.5	HSPD1, GLI2, GLRA1, HPRT1, HLA-C, HLA-DQB1
19	homeostasis/metabolism phenotype	MP:0005376	6.5	PSEN1, SOD1, FA2H, FASLG, MBP, GLI2
20	cellular phenotype	MP:0005384	6.5	L1CAM, B2M, MYC, VDR, VEGFA, BTK

Articles related to spastic paraparesis:

(show top 50)    (show all 77)

id	Title	Authors	Year	Affiliating Genes
1	Recessive spastic paraparesis associated with complex I deficiency due to MTHFR mutations. (21131308)	Bathgate D.... Chinnery P.F.	2012	MTHFR
2	Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. (21487076)	Erlich Y.... Elpeleg O.	2011	KIF1A
3	Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymph otropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru. (20483367)	Talledo M.... Van Laer L.	2010	KIR3DL1, HLA-A, HLA-C
4	Is oxidative damage in operation in patients with her editary spastic paraparesis? (19217230)	GA1cA1yener K.... TopaloA9lu H.	2010	SOD1
5	Evaluation of host genetic and viral factors as surro gate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in P eruvian HTLV-1-infected patients. (20087941)	Talledo M.... Van Laer L.	2010	HLA-A
6	Forceps minor region signal abnormality 'ears of the lynx': an early MRI finding in spastic paraparesis with thin corpus c allosum and mutations in the spatacsin gene (SPG11) on chromosome 15. (19040626)	Riverol M.... Masdeu J.C.	2009	SPG11
7	Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations. (19289482)	Scuderi C.... Musumeci S.A.	2009	SPAST
8	Novel PSEN1 mutation in a Bulgarian patient with very early-onset Alzheimer's disease, spastic paraparesis, and extrapyramidal signs . (19797784)	Dintchov Traykov L.... Van Broeckhoven C.	2009	PSEN1
9	Comparative study of CSF neurofilaments in HTLV-1-ass ociated myelopathy/tropical spastic paraparesis and other neurological disorder s. (19678766)	Alberti C.... Valenzuela M.	2009	NEFL, NEFH
10	Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia. (19068277)	Edvardson S.... Elpeleg O.	2008	FA2H
11	Mutations of the SPG11 gene in patients with autosomal recessive spastic paraparesis and thin corpus callosum. (18408091)	Lee M.J.... Yang C.C.	2008	SPG11
12	HSP60 is a rare cause of hereditary spastic paraparesis, but may act as a genetic modifier. (18458233)	Hewamadduma C.A.... Shaw P.J.	2008	HSPD1
13	SPG11 compound mutations in spastic paraparesis with thin corpus callosum. (18663179)	Samaranch L.... Pastor P.	2008	SPG11
14	A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease, seizures and cotton wool plaques, but not spastic paraparesis. (17645236)	Shrimpton A.E.... Davis R.L.	2007	PSEN1
15	A man with progressive spastic paraparesis (18098376)	Sanaker P.S.... Bindoff L.A.	2007	ABCD1
16	No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis. (17632280)	Karlstrom H.... Schofield P.R.	2007	PSEN1
17	Blockade of IL-2 receptor suppresses HTLV-I and IFN-gamma expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (17409595)	Fukushima N.... Eguchi K.	2007	IFNG, IL2RB
18	A presenilin 1 mutation (Arg278Ser) associated with early onset Alzheimer's disease and spastic paraparesis. (17507029)	Raman A.... Phillips M.F.	2007	PSEN1
19	High production of RANTES and MIP-1alpha in the tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). (17588676)	Montanheiro P.... Casseb J.	2007	GLI2, CCL3
20	Biological effects of four PSEN1 gene mutations causing Alzheimer disease with spastic paraparesis and cotton wool plaques. (16941492)	Dumanchin C.... Campion D.	2006	PSEN1
21	Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases. (16055926)	Depienne C.... Durr A.	2006	SPAST
22	Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: application of best-fit logistic regression equation based on host genotype, age, and provirus load. (16877298)	Nose H.... Osame M.	2006	CXCL12
23	Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)	Fukushima N.... Eguchi K.	2005	IFNG
24	ApaI polymorphism of vitamin D receptor gene is associated with susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in HTLV-1 infected individuals. (15850579)	Saito M.... Osame M.	2005	VDR
25	Increased mRNA expression of Th1-cytokine signaling molecules in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15572854)	Nishiura Y.... Eguchi K.	2004	IL12RB2, T
26	Serum concentration and genetic polymorphism in the 5'-untraslated region of VEGF is not associated with susceptibility to HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals. (15050452)	Saito M.... Osame M.	2004	VEGFA, CNTN2
27	Novel insertional presenilin 1 mutation causing Alzheimer disease with spastic paraparesis. (15159497)	Moretti P.... Foster N.L.	2004	PSEN1
28	A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)	Ataka S.... Miki T.	2004	PSEN1
29	Autonomic dysfunction in mental retardation and spastic paraparesis with MECP2 mutation. (15704871)	Dotti M.T.... Federico A.	2004	MECP2
30	From gene to disease; spastin and hereditary spastic paraparesis (14974310)	Bruyn R.P.... Frants R.R.	2004	SPAST
31	Infantile hereditary spastic paraparesis due to codominant mutations in the spastin gene. (15326248)	Chinnery P.F.... Dalton A.	2004	SPAST
32	Neuropsychological functions in variant Alzheimer's disease with spastic paraparesis. (14759630)	Verkkoniemi A.... Haltia M.	2004	PSEN1
33	Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin gene. (12876245)	Bonsch D.... Liepert J.	2003	SPAST
34	The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene. (14656074)	Wharton S.B.... Shaw P.J.	2003	SPAST
35	Investigation of mitochondrial function in hereditary spastic paraparesis. (12634509)	McDermott C.J.... Shaw P.J.	2003	SPG7, SPAST
36	Detection of myelin basic protein in cerebrospinal fluid and serum from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. (12564844)	Ohta M.... Saida T.	2002	MBP
37	Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease. (11836371)	Jacquemont M.L.... Durr A.	2002	PSEN1
38	A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. (11723204)	Mead S.H.... Warner T.T.	2001	SPAST
39	Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England. (11222789)	McDermott C.J.... Shaw P.J.	2001	SPG7
40	Frequent reversible membrane damage in peripheral blo od B cells in human T cell lymphotropic virus type I (HTLV-I)-associated myelop athy/tropical spastic paraparesis (HAM/TSP). (10792381)	Furukawa Y.... Osame M.	2000	ANXA5
41	Increased activity of metalloproteinases and their inhibitors in cerebrospinal fluid of patients with tropical spastic paraparesis (11016056)	Valenzuela M.A.... Cartier L.	2000	MMP9
42	Variant Alzheimer's disease with spastic paraparesis: clinical characterization. (10720282)	Verkkoniemi A.... Haltia M.	2000	PSEN1
43	Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. (10491011)	Azimi N.... Waldmann T.A.	1999	IL15
44	Increased levels of soluble Fas ligand in CSF of rapidly progressive HTLV-1-associated myelopathy/tropical spastic paraparesis patients. (10430056)	Saito M.... Osame M.	1999	FASLG
45	Genetic mapping to 10q23.3-q24.2, in a large Italian pedigree, of a new syndrome showing bilateral cataracts, gastroesophageal reflux, and spastic paraparesis with amyotrophy. (9973297)	Seri M.... Devoto M.	1999	SPG9
46	Genetic localization of a new locus for recessive familial spastic paraparesis to 15q13-15. (10408536)	Martinez Murillo F.... Hoffman E.P.	1999	L1CAM, SPG11
47	Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. (9491917)	Arai M.... Fujii M.	1998	PTPN13, CDKN3
48	Matrix metalloproteinase 9 (gelatinase B) in cerebrospinal fluid of HTLV-1 infected patients with tropical spastic paraparesis. (9633766)	Giraudon P.... Desgranges C.	1998	MMP9
49	CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. (8556302)	Fransen E.... Willems P.J.	1995	L1CAM
50	Demonstration of human T-cell lymphotropic virus type I (HTLV-I) from an HTLV-I seronegative south Indian patient with chronic, prog ressive spastic paraparesis. (8250538)	Nishimura M.... Jacobson S.	1993	IL2

Genes related to spastic paraparesis according to GeneCards:

(show top 50)    (show all 80)

id	Symbol	Description	Score	GeneCards Section Context
1	FA2H	fatty acid 2-hydroxylase	11.1	Summaries, Publications
2	PSEN1	presenilin 1	11.0	Publications
3	CD274	CD274 molecule	11.0	Publications
4	CX3CR1	chemokine (C-X3-C motif) receptor 1	11.0	Publications
5	PDCD1	programmed cell death 1	11.0	Publications
6	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
7	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
8	RPS27A	ribosomal protein S27a	11.0	Publications
9	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
10	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
11	MBP	myelin basic protein	11.0	Publications
12	IL2	interleukin 2	11.0	Publications
13	JUN	jun proto-oncogene	11.0	Publications
14	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
15	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.0	Publications
16	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.0	Publications
17	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.0	Publications
18	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	11.0	Publications
19	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
20	LTV1	LTV1 homolog (S. cerevisiae)	11.0
21	HBZ	hemoglobin, zeta	11.0
22	KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	11.0	Publications
23	KIR2DL4	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4	11.0	Publications
24	NEFH	neurofilament, heavy polypeptide	11.0	Publications
25	KIR2DL2	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2	11.0	Publications
26	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.0	Publications
27	NEFL	neurofilament, light polypeptide	11.0	Publications
28	T	T, brachyury homolog (mouse)	11.0	Publications
29	KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	11.0	Publications
30	CNTN2	contactin 2 (axonal)	11.0	Publications
31	KIR2DS4	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4	11.0	Publications
32	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0
33	CD8A	CD8a molecule	11.0
34	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
35	KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	11.0	Publications
36	KIR2DL3	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3	11.0	Publications
37	IL12RB1	interleukin 12 receptor, beta 1	11.0	Publications
38	GLRA1	glycine receptor, alpha 1	11.0	Publications
39	IL12RB2	interleukin 12 receptor, beta 2	11.0	Publications
40	IL15	interleukin 15	11.0	Publications
41	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
42	IL2RB	interleukin 2 receptor, beta	11.0	Publications
43	GLI2	GLI family zinc finger 2	11.0	Publications
44	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
45	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
46	ANXA5	annexin A5	11.0	Publications
47	B2M	beta-2-microglobulin	11.0	Publications
48	PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	11.0	Publications
49	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
50	CDKN3	cyclin-dependent kinase inhibitor 3	11.0	Publications

Pathways related to spastic paraparesis according to GeneDecks:

(show top 50)    (show all 59)

id	Pathway	Score	Top Affiliating Genes
1	OX40 Pathway36	10.6	JUN
2	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	IL10, FASLG, IL2RA, IL2RB, IL2
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	CCL3, FASLG, IL2RB, IL15, IL2, IL2RA
4	Immune response IL-2 activation and signaling pathway10	10.4	MYC, IL2RB, JUN
5	Immune response_IL-12 signaling pathway41	10.4	IFNG, IL12RB2, IL12RB1, IL2RA
6	Immune response IL-12 signaling pathway10	10.4	IL2RA, IL12RB2, IL12RB1, JUN, IFNG
7	Immune response_IL-2 activation and signaling pathway41	10.4	JUN, IL2, IL2RB, IL2RA, MYC
8	Immune response_Role of DAP12 receptors in NK cells41	10.4	HLA-B, KIR2DL1, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1
9	Cell adhesion molecules (CAMs)20	10.4	CD4, CNTN2, L1CAM, CD8A
10	Immune response Role of DAP12 receptors in NK cells10	10.4	KIR2DL1, KIR2DL4, KIR2DL5A, KIR2DS2, KIR2DS1, KIR2DL2
11	IL-2 Pathway36	10.2	IL2RA, IL2, JUN, MYC, IL2RB
12	CTL Mediated Apoptosis36	10.2	HLA-B, HLA-C, HLA-DQB1, HLA-A, HLA-DRB1
13	Chagas disease (American trypanosomiasis)20	10.2	FASLG, CCL3, IFNG, IL10, JUN, IL2
14	Graft-versus-host disease20	10.2	KIR2DL5A, KIR2DL2, KIR3DL1, KIR2DL3, KIR2DL1, KIR3DL2
15	Th1 Differentiation37	10.2	IL12RB1, IL12RB2, IL2, CD4, JUN, IFNG
16	T cell receptor signaling pathway20	10.1	PDCD1, JUN, CD8A, CD4, IL2, IL10
17	Intestinal immune network for IgA production20	10.1	IL10, CXCL12, HLA-DRB1, IL15, IL2, HLA-DQB1
18	Autoimmune thyroid disease20	10.1	HLA-B, HLA-DRB1, HLA-A, FASLG, IL2, IL10
19	ICos-ICosL Pathway in T-Helper Cell36	10.1	HLA-DRB1, IL2, CD4, IL2RA, IL2RB, HLA-DQB1
20	Jak-STAT signaling pathway20	10.1	IL10, IL12RB1, IL12RB2, IL15, IL2, IL2RA
21	THC Differentiation Pathway36	10.1	IL2RA, IFNG, HLA-DQB1, HLA-DRB1, IL2, IL12RB2
22	Immune response IL-22 signaling pathway10	10.0	HLA-DQB1, IL2RA, IL2, IL12RB1, IL12RB2, CD4
23	Immune System38	10.0	IFNG, KIR2DL2, CD274, KIR2DS4, KIR3DL1, KIR2DS2
24	Immune response_IL-22 signaling pathway41	10.0	IL2RA, HLA-DRB1, HLA-DQB1, IL2RB, IL2, IL12RB2
25	Immune response Antigen presentation by MHC class I10	10.0	HLA-B, CD8A, HLA-C, B2M, HLA-A
26	Allograft rejection20	10.0	IL2, FASLG, IFNG, HLA-A, HLA-B, HLA-C
27	Rheumatoid arthritis20	9.9	CXCL12, VEGFA, CCL3, JUN, IL15, IFNG
28	PGC1Alpha Pathway36	9.9	BTK, CCL3, IL2RB, IL2, IL15, CD4
29	IL-6 Pathway36	9.9	IL10, BTK, CCL3
30	Lymphocyte Signaling3	9.9	FASLG, IL2RB, IL2RA, CD4, CD8A, B2M
31	Viral myocarditis20	9.8	HLA-B, HLA-DQB1, HLA-DRB1, HLA-C, HLA-A
32	Natural killer cell mediated cytotoxicity20	9.8	HLA-C, HLA-B, FASLG, KIR2DL2, KIR2DS1, KIR2DL5A
33	Endothelin-1 Signaling Pathway36	9.8	MYC, IL10, IL2, CCL3, CXCL12, BTK
34	Molecular Mechanisms of Cancer36	9.7	CX3CR1, MYC, PSEN1, CD4, IL12RB2, IL15
35	MIF Regulation of Innate Immune Cells36	9.7	IL10, BTK, CXCL12, CCL3, IL2, IL15
36	Cytokine-cytokine receptor interaction20	9.7	VEGFA, IL10, IL12RB2, CXCL12, CX3CR1, IL12RB1
37	Glucocorticoid Receptor Signaling36	9.6	CCL3, IL15, IL10, CD4, JUN, BTK
38	Type I diabetes mellitus20	9.6	IL2, IFNG, HSPD1, FASLG, HLA-B, HLA-C
39	NFAT Signaling and Lymphocyte Interactions36	9.6	CXCL12, CCL3, IL2RB, IL2RA, IL2, IL15
40	Antigen processing and presentation20	9.6	KIR2DS5, KIR2DS3, KIR3DL2, KIR3DL3, HLA-DRB1, HLA-C
41	MIF Mediated Glucocorticoid Regulation36	9.6	IL10, IL15, CCL3, CXCL12, IL2, BTK
42	Leishmaniasis20	9.6	JUN, IL10, IFNG, HLA-DQB1, HLA-DRB1
43	TGF-Beta Pathway36	9.5	IL2RA, JUN, IL10, CD4, BTK, IL15
44	Akt Signaling36	9.4	CCL3, IL2RB, IL2RA, IL10, CX3CR1, IL15
45	STAT3 Pathway36	9.4	IL12RB1, IL12RB2, IL10, CD4, MYC, CCL3
46	MAPK Family Pathway36	9.4	CXCL12, CCL3, IL2RB, IL2RA, IL2, IL15
47	Tec Kinases Signaling36	9.4	CD4, CX3CR1, IL2RB, IL2RA, IL2, IL15
48	JAK-STAT Pathway36	9.4	IL2RA, IL2RB, CCL3, CXCL12, IFNG, IL2
49	Antioxidant Action of Vitamin-C36	9.4	IL2, IL2RA, CCL3, BTK, CX3CR1, CXCL12
50	p38 Signaling36	9.3	BTK, IL12RB2, IL12RB1, IL10, CD4, IL15

Compounds related to spastic paraparesis according to GeneDecks:

(show top 50)    (show all 159)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.6	FASLG, CD4, CCL3
2	rapamycin32 42	11.4	IL2RB, IFNG, RPS27A, VEGFA, IL2
3	ivig32	10.3	MBP, FASLG, BTK
4	ionomycin32	10.2	CCL3, CNTN2, BTK, CD274, IL12RB1, PSEN1
5	il 1032	10.1	IL2RB, CCL3, IFNG, VDR, CD8A, IL2RA
6	2,5-oligoadenylate32	10.1	IL10, IFNG, IL2RB, HLA-B, IL2RA, IL2
7	lactacystin32	10.1	PSEN1, CDKN3, VDR, MYC, JUN, CD4
8	prednisolone32 9 9	12.0	IL2RB, IL2RA, IL10, IL2, CDKN3, MYC
9	ifn-alpha32	10.0	FASLG, IL10, IL2, IL2RA, IL2RB, CXCL12
10	herbimycin a32 42	11.0	RPS27A, IFNG, MMP9, CDKN3, CD4, JUN
11	neopterin32	10.0	IL2RB, IL2, IL2RA, B2M, CD4, CCL3
12	zidovudine32 9 9	11.9	IL2, B2M, MYC, CNTN2, CD4, CCL3
13	infliximab32 9 9	11.9	IL10, VEGFA, IFNG, IL2RA, ANXA5, IL2RB
14	okt332	9.9	IFNG, IL10, IL15, IL2, IL2RA, IL2RB
15	triptolide32	9.9	ANXA5, CCL3, VEGFA, JUN, IFNG, IL2
16	gm-csf32	9.9	VEGFA, IL10, CCL3, IL2, IL15, IFNG
17	n acetylcysteine32	9.8	IL2RA, IL2RB, MBP, ANXA5, RPS27A, HSPD1
18	tacrolimus32 34 9 9	12.8	CDKN3, IL2RB, HLA-B, VDR, MYC, IL10
19	ccl332	9.8	CCL3, IL15, IL10, MMP9, IFNG, CX3CR1
20	5-aza-2deoxycytidine32	9.7	MYC, HLA-B, RPS27A, MECP2, KIR3DL1, HLA-A
21	actinomycin d32	9.7	VEGFA, VDR, MYC, JUN, CDKN3, CXCL12
22	biotin32 9 18 9	12.6	HSPD1, CDKN3, FASLG, BTD, B2M, RPS27A
23	vegf32	9.6	CNTN2, SERPINH1, MYC, CDKN3, MMP9, CCL3
24	aspartate32	9.6	RPS27A, MBP, CCL3, FASLG, IL2RB, B2M
25	sb 20358032 42	10.5	MMP9, ANXA5, IFNG, CXCL12, VDR, VEGFA
26	5fluorouracil32	9.3	VDR, CXCL12, HLA-A, IFNG, CCL3, ANXA5
27	sodium arsenite32	9.2	FASLG, SOD1, HSPD1, IL2RA, SERPINH1, JUN
28	methotrexate32 34 42 9 9	13.2	FASLG, MTHFR, HPRT1, MBP, IL2RB, IL2RA
29	rantes32	9.1	CD4, MMP9, JUN, IL15, IL2, IL2RA
30	genistein32 9 18 9	12.0	VEGFA, IFNG, CXCL12, IL2RB, FASLG, IL2RA
31	thymidine32 18	9.9	IL15, IL2, IL2RA, IL2RB, IFNG, CCL3
32	oligonucleotide32	8.8	MYC, PSEN1, BTK, KIR3DL1, CNTN2, IL15
33	arsenite32 18	9.7	SOD1, RPS27A, CDKN3, CNTN2, VEGFA, VDR
34	cisplatin32 34 9 9	11.7	B2M, MTHFR, MYC, VEGFA, MBP, CDKN3
35	paraffin32	8.7	MMP9, NEFH, RPS27A, HLA-B, MBP, FASLG
36	indomethacin32 9 9	10.7	CDKN3, SOD1, RPS27A, HSPD1, ANXA5, MBP
37	dexamethasone32 42 34 9 9	12.7	IL2, FASLG, IL2RB, IL2RA, IL15, IL12RB1
38	cysteine32	8.6	IL15, MMP9, CD4, FASLG, CNTN2, MTHFR
39	guanine32 9 18 9	11.6	L1CAM, CCL3, CNTN2, VDR, RASA2, MTHFR
40	cycloheximide32	8.4	VEGFA, RPS27A, PTPN13, HSPD1, IFNG, IL10
41	glutamate32	8.2	NEFL, CXCL12, RPS27A, SPG7, HPRT1, GLRA1
42	retinoic acid32 42 18	10.2	MMP9, IL15, KIR2DS4, CNTN2, JUN, B2M
43	cyclosporin a32 42	9.1	RPS27A, HLA-B, SERPINH1, CNTN2, VDR, MYC
44	lactate32	8.1	MMP9, HLA-B, BTD, B2M, CDKN3, IL2RB
45	arginine32	8.0	RPS27A, IL2RB, MBP, GLRA1, HLA-A, HLA-B
46	phosphatidylinositol32	7.9	CD4, JUN, MYC, BTK, RASA2, CDKN3
47	serine32	7.8	SERPINH1, VDR, MYC, MTHFR, B2M, MBP
48	creatinine32	7.7	B2M, IL15, MMP9, IL2RB, VDR, MTHFR
49	alanine32	7.0	MYC, VDR, BTD, CNTN2, MTHFR, RPS27A
50	tyrosine32	5.9	PDCD1, IL12RB2, IL15, IL2, IL2RA, IL2RB

Cellular components related to spastic paraparesis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	10.1	B2M, HLA-A, HLA-B, HLA-C
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.0	HLA-B, HLA-DQB1, HLA-C, HLA-DRB1, HLA-A
3	ER to Golgi transport vesicle membrane	GO:012507	9.9	B2M, HLA-C, HLA-DQB1, HLA-DRB1, HLA-A, HLA-B
4	phagocytic vesicle membrane	GO:030670	9.8	HLA-B, HLA-A, B2M, HLA-C
5	external side of plasma membrane	GO:009897	9.5	CXCL12, B2M, CD8A, CD4, CD274, IL12RB1
6	integral to plasma membrane	GO:005887	9.1	KIR2DL4, KIR3DS1, KIR2DS4, KIR3DL1, KIR2DL1, KIR3DL2
7	cytoplasmic vesicle	GO:031410	8.8	SPG11, SOD1, PSEN1, SPAST, BTK
8	extracellular space	GO:005615	7.6	IL2, FASLG, HSPD1, CCL3, CXCL12, SOD1
9	plasma membrane	GO:005886	6.6	PDCD1, RPS27A, PSEN1, CX3CR1, SOD1, HLA-DQB1

Biological processes related to spastic paraparesis according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.3	HLA-A, HLA-B, HLA-C, B2M
2	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.3	HLA-B, HLA-A, RPS27A, B2M, HLA-C
3	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.2	B2M, RPS27A, HLA-C, HLA-B, HLA-A
4	T cell costimulation	GO:031295	10.2	HLA-DRB1, HLA-DQB1, CD274, PDCD1, CD4
5	detection of bacterium	GO:016045	10.2	HLA-A, HLA-B, HLA-DRB1
6	T cell receptor signaling pathway	GO:050852	10.1	RPS27A, CD4, HLA-DQB1, HLA-DRB1, PSEN1
7	positive regulation of interferon-gamma production	GO:032729	9.9	IL2, IL12RB1, IL12RB2, HSPD1
8	interferon-gamma-mediated signaling pathway	GO:060333	9.9	HLA-DQB1, HLA-DRB1, HLA-B, HLA-A, IFNG, B2M
9	regulation of immune response	GO:050776	9.8	CD8A, HLA-C, HLA-B, HLA-A, B2M, KIR2DL2
10	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	9.8	B2M, HLA-B, HLA-C, RPS27A, HLA-A
11	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.8	VDR, IFNG, GLI2, FASLG, HBZ, PSEN1
12	cytokine-mediated signaling pathway	GO:019221	9.7	HLA-C, HLA-B, HLA-A, IFNG, IL12RB1, IL12RB2
13	positive regulation of cell proliferation	GO:008284	9.5	IL15, VEGFA, MECP2, FASLG, IL2, MYC
14	immune response	GO:006955	9.2	CXCL12, CD4, MBP, KIR2DS1, KIR2DS2, KIR3DL1
15	signal transduction	GO:007165	9.2	IL15, CXCL12, IL2RB, FASLG, ANXA5, IL12RB1
16	cell death	GO:008219	8.7	MTPAP, NEFH, KIF1A, FA2H, SPG11, SPG7

Molecular functions related to spastic paraparesis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I receptor activity	GO:032393	10.1	HLA-B, HLA-A, KIR3DS1, HLA-C
2	cytokine activity	GO:005125	9.9	VEGFA, IFNG, FASLG, IL2, IL15, IL10
3	protein binding	GO:005515	5.2	SPAST, GLRA1, GLI2, HSPD1, CCL3, FASLG