MCID: SPS019
MIFTS: 49

Spastic Paraparesis malady

Summaries for Spastic Paraparesis

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33MalaCards
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MalaCards: Spastic Paraparesis is related to tropical spastic paraparesis and t-cell leukemia. An important gene associated with Spastic Paraparesis is FA2H (fatty acid 2-hydroxylase), and among its related pathways are Notch Pathway and Apoptosis Pathway. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and kidney, and related mouse phenotypes are skeleton and digestive/alimentary.

Aliases & Classifications for Spastic Paraparesis

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

spastic paraparesis 43


Related Diseases for Spastic Paraparesis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Spastic Paraparesis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1tropical spastic paraparesis32.0FASLG, MBP, IL2, IL2RA
2t-cell leukemia31.2IL2, IL2RA, JUN, FASLG, NFKB1, MYC
3alzheimer's disease31.1PSEN1, JUN, RPS27A
4amyotrophic lateral sclerosis30.4RPS27A, PSEN1
5vasculitis30.3NFKB1
6polymyositis30.3RPS27A, JUN
7thyroiditis30.1FASLG
8acute leukemia30.1IL2
9synovitis30.1CX3CR1
10systemic lupus erythematosus30.1RPS27A, PDCD1, KLRK1, FASLG, HLA-A, IL2RA
11adult t-cell leukemia10.6
12ataxia10.6
13htlv-1 associated myelopathy/tropical spastic paraparesis10.6
14hereditary spastic paraplegia10.4
15lateral sclerosis10.4
16friedreich ataxia10.4
17adrenomyeloneuropathy10.4
18wells-jankovic syndrome10.4
19leukodystrophy, dysmyelinating, and spastic paraparesis with or without dystonia10.4
20htlv-1 associated myelopathy10.4
21retrovirus-associated myelopathy10.4
22leukemia/lymphoma, t-cell10.4
23myelitis10.3
24adrenoleukodystrophy10.3
25adult lymphoma10.3
26n syndrome10.3
27spinal cord disease10.3
28spinal cord ischemia10.3
29sensorineural hearing loss10.2
30lyme disease10.2
31addison's disease10.2
32fatty acid hydroxylase-associated neurodegeneration10.2
33hereditary ataxia10.2
34hyperekplexia10.2
35troyer syndrome10.2
36spastic paraplegia 910.2
37mental retardation10.2
38autonomic dysfunction10.2
39spasticity10.2
40tremor10.2
41alzheimer disease, type 3, with spastic paraparesis and unusual plaques10.2
42alzheimer disease, type 3, with spastic paraparesis and apraxia10.2
43sjogren-larsson syndrome10.1
44spastic diplegia10.1
45strongyloidiasis10.1
46machado-joseph disease10.1
47pigmented villonodular synovitis10.1
48syringomyelia10.1
49folliculitis10.1
50fibrous histiocytoma10.1

Graphical network of the top 20 diseases related to Spastic Paraparesis:



Diseases related to spastic paraparesis

Clinical Features for Spastic Paraparesis

Drugs & Therapeutics for Spastic Paraparesis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spastic Paraparesis

Anatomical Context for Spastic Paraparesis

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33MalaCards
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MalaCards organs/tissues related to Spastic Paraparesis:

33
Spinal cord, Brain, Kidney, Thymus, Skeletal muscle, Thyroid, Nk cells, T cells, B cells, Amygdala

Animal Models for Spastic Paraparesis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Spastic Paraparesis

Sources:
51PubMed
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Articles related to Spastic Paraparesis:

(show top 50)    (show all 597)
idTitleAuthorsYear
1
Variant Alzheimer's disease with spastic paraparesis and supranuclear gaze palsy. (23419577)
2013
2
Service delivery for people with hereditary spastic paraparesis living in the South West of England. (23944176)
2013
3
A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis. (22717650)
2012
4
Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects. (22405461)
2012
5
Characteristics of Chronic Pain and Its Impact on Quality of Life of Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). (20842011)
2011
6
Botulinum toxin injections for pediatric patients with hereditary spastic paraparesis. (20406997)
2010
7
Therapeutic strategies in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (20021347)
2009
8
Human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in an HIV-positive patient coinfected with human T lymphotropic virus type 2 following initiation of antiretroviral therapy. (17918071)
2007
9
Hereditary spastic paraparesis in adults associated with inborn errors of metabolism: a diagnostic approach. (17957490)
2007
10
HTLV-I and neurological disease: from tropical spastic paraparesis to HTLV-I-associated myelopathy: what next? (18090720)
2007
11
General anaesthesia and Caesarean section for a patient with hereditary spastic paraparesis (Strumpell's disease). (17275279)
2007
12
Restless legs syndrome in hereditary spastic paraparesis. (17108692)
2007
13
Spastic paraparesis as a complication of percutaneous nephrolithothripsy (PNL) on a calyceal calculus of the left kidney. (18303729)
2007
14
High production of RANTES and MIP-1alpha in the tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). (17588676)
2007
15
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
16
Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease. (16545011)
2006
17
Intrathecal nicorandil and small-dose morphine can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat. (16551926)
2006
18
Gene symbol: SPAST (SPG4). Disease: Spastic paraparesis. Accession #Hm0552. (17297708)
2006
19
Clinical and epidemiological aspects of HTLV-II infection in SALo Paulo, Brazil: presence of tropical spastic paraparesis/HTLV-associated myelopathy (TSP/HAM) simile diagnosis in HIV-1-co-infected subjects. (17119676)
2006
20
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. (15961107)
2005
21
Tropical spastic paraparesis/human T leukemia virus type 1-associated myelopathy in HIV type 1-coinfected patients. (16107970)
2005
22
A novel presenilin 1 mutation (Y154N) in a patient with early onset Alzheimer's disease with spastic paraparesis. (15364419)
2004
23
Decreased human T lymphotropic virus type I (HTLV-I) provirus load and alteration in T cell phenotype after interferon-alpha therapy for HTLV-I-associated myelopathy/tropical spastic paraparesis. (14702150)
2004
24
Cyclosporine-induced reversible pure motor spastic paraparesis in a patient with aplastic anaemia. (12568232)
2002
25
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
26
Intramedullary enterogenous cyst presenting with spastic paraparesis during two consecutive pregnancies: a case report. (11561041)
2001
27
Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. (11120926)
2001
28
Novel missense mutation in the L1 gene in a child with corpus callosum agenesis, retardation, adducted thumbs, spastic paraparesis, and hydrocephalus. (10805190)
2000
29
Bilateral sensorineural hearing loss and spastic paraparesis in Lyme disease. (10699828)
2000
30
Human T-cell lymphotropic virus type 1-associated neurologic disorder without spastic paraparesis. (10488823)
1999
31
Extended extradural spinal arachnoid cyst: an unusual cause of progressive spastic paraparesis. (10622457)
1999
32
A case of Machado-Joseph disease presenting with spastic paraparesis. (9153623)
1997
33
Human T-cell lymphotropic virus type 1 myositis, peripheral neuropathy, and cerebral white matter lesions in the absence of spastic paraparesis. (9236579)
1997
34
Association of late onset spastic paraparesis and dementia: probably an autosomal dominant form of complicated paraplegia. (8986267)
1997
35
Virological aspects of tropical spastic paraparesis/HTLV-I associated myelopathy and HTLV-I infection. (8912206)
1996
36
Familial hyperlysinemia in a patient presenting with progressive spastic paraparesis. (8797497)
1996
37
Dietary determinants of a non-progressive spastic paraparesis (Konzo): a case-referent study in a high incidence area of Zaire. (8557452)
1995
38
Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. (7512153)
1994
39
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. (8372632)
1993
40
Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. (1520534)
1992
41
Antibody titers to HTLV-I-p40tax protein and gag-env hybrid protein in HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with increased HTLV-I proviral DNA load. (1578240)
1992
42
Multiple sclerosis, tropical spastic paraparesis and HTLV-1 infection in Afro-Caribbean patients in the United Kingdom. (1940939)
1991
43
HTLV-I-associated myelopathy, tropical spastic paraparesis, and Borrelia burgdorferi. (2327742)
1990
44
Is myelopathy of unknown origin related with tropical spastic paraparesis and myelopathy associated with human T cell lymphotropic virus type I? (2340835)
1990
45
Methylprednisolone therapy in tropical spastic paraparesis. (2313308)
1990
46
Tropical spastic paraparesis and human T-cell lymphotropic virus type 1. (2303827)
1990
47
Identity of HTLV-I-associated tropical spastic paraparesis and HTLV-I-associated myelopathy. (2894583)
1988
48
HTLV-I-associated tropical spastic paraparesis in Martinique: a reappraisal. (2894804)
1988
49
Multiple sclerosis (not tropical spastic paraparesis) on Key West, Florida. (2883504)
1987
50
Treponematoses and tropical spastic paraparesis. (2870309)
1986

Genetic Variations for Spastic Paraparesis

Expression for genes affiliated with Spastic Paraparesis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spastic Paraparesis

Search GEO for disease gene expression data for Spastic Paraparesis.

Pathways for genes affiliated with Spastic Paraparesis

Sources:
60Tocris Bioscience, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN, 50PharmGKB, 30KEGG
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Pathways related to Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MYC, PSEN1
2
Hide members
10.4IL2RA, JUN
3
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10.4IL2, IL2RA, FASLG
410.4JUN, PSEN1, MYC
5
Hide members
10.4FASLG, MYC, NFKB1
610.4NFKB1, MYC, IL2RA
7
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.4JUN, VDR, FASLG
8
Hide members
10.4NFKB1, JUN, RPS27A
910.4JUN, IL2RA, IL2
1010.4VDR, JUN, MYC
1110.4NFKB1, JUN, MYC
12
Hide members
10.4JUN, NFKB1, MYC
13
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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10.4JUN, MYC, NFKB1
1410.4JUN, IL2, NFKB1
1510.4JUN, IL2, NFKB1
16
Apoptosis and survival Lymphotoxin-beta receptor signaling
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10.4NFKB1, JUN, IL2
1710.4JUN, NFKB1, IL2
1810.4IL2, NFKB1, JUN
19
Hide members
10.4NFKB1, HLA-A, RPS27A, KLRK1
20
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10.4RPS27A, IL2, IL2RA, NFKB1
21
Hide members
10.4JUN, IL2RA, FASLG, IL2
22
Hide members
10.4MYC, NFKB1, FASLG, JUN
2310.4MYC, FASLG, JUN, NFKB1
24
Hide members
10.4JUN, NFKB1, FASLG, MYC
25
Hide members
10.4NFKB1, JUN, FASLG, MYC
26
Hide members
10.4NFKB1, PDCD1, JUN, IL2
2710.4IL2, JUN, MYC, IL2RA
28
Hide members
10.4JUN, MYC, IL2RA, IL2
2910.4MYC, JUN, NFKB1, HLA-A
30
Hide members
10.4NFKB1, IL2, JUN, IL2RA
31
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10.4IL2RA, JUN, NFKB1, IL2
32
Hide members
10.4MYC, CX3CR1, NFKB1, IL2RA, FASLG
3310.4JUN, NFKB1, MYC, IL2
34
Hide members
10.4CX3CR1, MYC, PSEN1, JUN, NFKB1
35
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10.4FASLG, JUN, MYC, NFKB1, PSEN1
36
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10.4IL2RA, NFKB1, IL2, RPS27A, HLA-A
37
Hide members
10.4IL2RA, FASLG, IL2, NFKB1, MYC
3810.4FASLG, NFKB1, MYC, IL2RA, IL2
3910.4JUN, IL2RA, HLA-A, FASLG, IL2
40
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10.3IL2, MYC, FASLG, JUN, NFKB1
41
Immune response IL-2 activation and signaling pathway
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10.3IL2, IL2RA, MYC, NFKB1, JUN
42
Hide members
10.3IL2, IL2RA, MYC, NFKB1, JUN
43
Hide members
10.3JUN, IL2, PSEN1, IL2RA, MYC, NFKB1
44
Hide members
10.3HLA-A, NFKB1, IL2, FASLG, IL2RA, JUN
45
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10.3FASLG, HLA-A, NFKB1, IL2, JUN, IL2RA
4610.3JUN, IL2, IL2RA, HLA-A, MYC, NFKB1
47
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10.3KIR2DS2, KIR2DS5, IL2, KIR2DL5A, KIR2DS1
48
Hide members
10.3KIR2DS2, KIR2DS1, KIR2DS5, KLRK1, RPS27A, NFKB1
49
Hide members
10.3NFKB1, HLA-A, CD274, PDCD1, KLRK1, JUN
50
Hide members
10.2KIR2DS1, KIR2DS2, KIR2DL5A, IL2, NFKB1, HLA-A

Compounds for genes affiliated with Spastic Paraparesis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Spastic Paraparesis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.9PSEN1, FASLG
2indomethacin45 60 29 1113.8MBP, RPS27A
3pge24510.8IL2
4c-d4t4510.8FASLG, IL2, IL2RA
5arsenite45 2411.8VDR, FASLG, RPS27A
6dexamethasone45 50 29 1113.8MYC, FASLG, VDR, JUN
7sodium arsenite4510.8IL2RA, FASLG, MYC, JUN
8lactacystin4510.8VDR, JUN, RPS27A, FASLG, PSEN1, MYC
9tamoxifen45 50 29 1113.8RPS27A, JUN, VDR, IL2, FASLG
10mg 13245 6011.8VDR, MYC, JUN, RPS27A, FASLG
11propanil4510.8IL2, MYC, RPS27A
12ionomycin4510.8FASLG, JUN, IL2RA, CD274, PSEN1, IL2
134-hydroxytamoxifen4510.8MYC, FASLG, VDR, JUN
14herbimycin a45 6011.8RPS27A, JUN, MYC, IL2RA, IL2
15bortezomib45 1111.8MYC, RPS27A, JUN, FASLG
16tacrolimus45 50 1112.8IL2RA, FASLG, IL2, VDR, MYC, HLA-A
17n acetylcysteine4510.8MBP, RPS27A, MYC, FASLG, JUN, IL2RA
18rapamycin4510.7IL2RA, JUN, FASLG, MYC, IL2, RPS27A
19thalidomide45 50 60 1113.7IL2RA, IL2, NFKB1, FASLG
204-hydroxynonenal45 2411.7PSEN1, RPS27A, JUN, MYC
21calcitriol45 60 11 2413.7MYC, JUN, IL2, VDR, IL2RA
22actinomycin d4510.7JUN, IL2, MYC, VDR, FASLG, RPS27A
235fluorouracil4510.7IL2RA, VDR, HLA-A, FASLG, IL2
24thymidine45 2411.7JUN, IL2, IL2RA, VDR, MYC, FASLG
25anisomycin45 1111.7MYC, FASLG, JUN, IL2RA
26genistein45 29 60 2 11 2415.7JUN, FASLG, IL2RA, MYC, VDR, IL2
27levamisole45 1111.7IL2RA, IL2, HLA-A
28rantes4510.7JUN, FASLG, IL2RA, IL2
29butyrate4510.7RPS27A
30cyclosporin a45 29 6012.7VDR, IL2, HLA-A, RPS27A, JUN, MBP
31retinoic acid45 2411.7RPS27A, JUN, MYC, VDR, KLRK1, PSEN1
32cisplatin45 50 60 1113.7IL2, FASLG, MBP, RPS27A, MYC, IL2RA
33vegf4510.7RPS27A, JUN, FASLG, MYC, CX3CR1, IL2RA
34etoposide45 50 60 1113.6NFKB1, MYC, FASLG, JUN, IL2RA
35tyrosine4510.6JUN, FASLG, RPS27A, PDCD1, KIR2DL5A, IL2
36phosphatidylinositol4510.6FASLG, KLRK1, MYC, CX3CR1, PSEN1, IL2RA
37arginine4510.6HLA-A, PSEN1, IL2RA, VDR, KLRK1, RPS27A
38aspartate4510.6RPS27A, IL2RA, VDR, FASLG, MBP, PSEN1
39estrogen4510.6VDR
40biotin45 11 2412.6IL2, FASLG, RPS27A, PSEN1
41cytarabine45 50 1112.6MYC, FASLG, MBP, JUN
42adenylate4510.6HLA-A, IL2RA, MBP, VDR, RPS27A, FASLG
43alanine4510.6FASLG, MYC, HLA-A, VDR, MBP, PSEN1
44prednisolone45 29 1112.6MYC, IL2RA, MBP
45h2o24510.4IL2RA, MBP, JUN, FASLG, RPS27A, PSEN1
46camptothecin45 60 1112.4MYC, FASLG, JUN, RPS27A
472-chlorodeoxyadenosine4510.4IL2RA, FASLG, IL2
48imatinib45 50 1112.4FASLG, KLRK1, RPS27A, MYC
49cysteine4510.2VDR, RPS27A, FASLG, IL2RA, PSEN1, MBP
50cyclophosphamide45 50 1112.1IL2, IL2RA, FASLG, MBP

GO Terms for genes affiliated with Spastic Paraparesis

Sources:
16Gene Ontology
See all sources

Cellular components related to Spastic Paraparesis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4IL2RA, CD274, FASLG, PDCD1
2plasma membraneGO:0058869.9KIR2DS5, RPS27A, PDCD1, MBP, HLA-A, CD274

Biological processes related to Spastic Paraparesis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:04601310.8IL2, IL2RA
2Notch signaling pathwayGO:00721910.7RPS27A, PSEN1, MYC, IL2RA
3cerebral cortex cell migrationGO:02179510.7CX3CR1, PSEN1
4negative regulation of inflammatory responseGO:05072810.7IL2, IL2RA, NFKB1
5toll-like receptor 10 signaling pathwayGO:03416610.7RPS27A, JUN, NFKB1
6negative regulation of apoptotic processGO:04306610.7RPS27A, PSEN1, NFKB1, MYC, CX3CR1, IL2
7toll-like receptor 5 signaling pathwayGO:03414610.7RPS27A, JUN, NFKB1
8negative regulation of transcription from RNA polymerase II promoterGO:00012210.7RPS27A, FASLG, PSEN1, NFKB1, MYC, VDR
9toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.7RPS27A, JUN, NFKB1
10toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.7RPS27A, JUN, NFKB1
11toll-like receptor 9 signaling pathwayGO:03416210.6NFKB1, JUN, RPS27A
12positive regulation of transcription from RNA polymerase II promoterGO:04594410.6RPS27A, JUN, NFKB1, MYC, VDR, IL2
13toll-like receptor 2 signaling pathwayGO:03413410.6RPS27A, JUN, NFKB1
14innate immune responseGO:04508710.6RPS27A, JUN, NFKB1, KIR2DS2, KIR2DS1, KIR2DS5
15TRIF-dependent toll-like receptor signaling pathwayGO:03566610.6NFKB1, JUN, RPS27A
16MyD88-independent toll-like receptor signaling pathwayGO:00275610.6RPS27A, JUN, NFKB1
17immune responseGO:00695510.6KIR2DS5, MBP, FASLG, HLA-A, CD274, IL2RA
18toll-like receptor 3 signaling pathwayGO:03413810.5RPS27A, JUN, NFKB1
19MyD88-dependent toll-like receptor signaling pathwayGO:00275510.5RPS27A, JUN, NFKB1
20positive regulation of apoptotic processGO:04306510.5IL2RA, PSEN1, FASLG, RPS27A
21response to growth factor stimulusGO:07084810.4FASLG, MYC
22toll-like receptor 4 signaling pathwayGO:03414210.4RPS27A, JUN, NFKB1
23T cell receptor signaling pathwayGO:05085210.3NFKB1, PSEN1, RPS27A
24regulation of immune responseGO:05077610.1KIR2DS2, KIR2DS1, HLA-A

Products for genes affiliated with Spastic Paraparesis

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Sources for Spastic Paraparesis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet