Spastic Paraplegia 17 malady

Genetics Home Reference: Silver syndrome belongs to a group of genetic disorders known as hereditary spastic paraplegias. These disorders are characterized by progressive muscle stiffness (spasticity) and, frequently, development of paralysis of the lower limbs (paraplegia). Hereditary spastic paraplegias are divided into two types: pure and complex. Both types involve the lower limbs; the complex types may also involve the upper limbs, although to a lesser degree. In addition, the complex types may affect the brain and parts of the nervous system involved in muscle movement and sensations. Silver syndrome is a complex hereditary spastic paraplegia.¹⁷

MalaCards: Spastic Paraplegia 17, also known as silver syndrome, is related to silver-russell syndrome and distal hereditary motor neuropathy. An important gene associated with Spastic Paraplegia 17 is BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)). Affiliated tissues include brain.

spastic paraplegia 17 30 16 17 43 silver syndrome 30 16 17 spg17 30 16 17 spastic paraplegia with amyotrophy of hands and feet 30 17

autosomal dominant spastic paraplegia type 17 30 silver spastic paraplegia syndrome 30 spg 17 16 hsp17 16

Disease types for spastic paraplegia family:

spastic paraplegia 3a	spastic paraplegia 8
spastic paraplegia type 4	spastic paraplegia type 11
spastic paraplegia 1	spastic paraplegia 10
spastic paraplegia 12	spastic paraplegia 13
spastic paraplegia 14	spastic paraplegia 15
spastic paraplegia 16	spastic paraplegia 17
spastic paraplegia 18	spastic paraplegia 19
spastic paraplegia 20	spastic paraplegia 23
spastic paraplegia 24	spastic paraplegia 25
spastic paraplegia 26	spastic paraplegia 29
spastic paraplegia 3	spastic paraplegia 31
spastic paraplegia 39	spastic paraplegia 5a
spastic paraplegia 5b	spastic paraplegia 6
spastic paraplegia 9	spastic paraplegia 30
spastic paraplegia 33	spastic paraplegia 35
spastic paraplegia 42	spastic paraplegia 44
spastic paraplegia 48	spastic paraplegia 41
spastic paraplegia-38	spastic paraplegia 45
spastic paraplegia-37	spastic paraplegia-32
spastic paraplegia-27	spastic paraplegia-36
spastic paraplegia-28

Diseases related to spastic paraplegia 17 by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	silver-russell syndrome	9.3
2	distal hereditary motor neuropathy	7.5
3	chromosome 11p15.5-related russell-silver syndrome	7.2
4	chromosome 7-related russell-silver syndrome	7.2
5	der kaloustian mcintosh silver syndrome	7.2
6	partington syndrome	6.6
7	rigid spine syndrome	6.6
8	snyder-robinson syndrome	6.6
9	distal hereditary motor neuropathy type v	5.7
10	silvery hair syndrome	5.7

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spastic paraplegia 17:

²²

Articles related to spastic paraplegia 17:

id	Title	Authors	Year	Affiliating Genes
1	Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. (18585921)	Ito D.... Suzuki N.	2008	BSCL2

Genes related to spastic paraplegia 17 according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	11.1	Publications, Disorders, Aliases & Descriptions