MCID: SPS004
MIFTS: 32

Spastic Quadriplegia malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Spastic Quadriplegia

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Aliases & Descriptions for Spastic Quadriplegia:

Name: Spastic Quadriplegia 10 47 12 65
Spastic Quadriplegic Cerebral Palsy 10 45
Cerebral Palsy, Quadriplegic, Infantile 65
Quadriplegic Infantile Cerebral Palsy 10
Tetraplegic Infantile Cerebral Palsy 10
 
Spastic Quadriplegia Cerebral Palsy 45
Cerebral Palsy Spastic Quadriplegic 45
Quadriplegic Spastic Cerebral Palsy 65
Spastic Tetraplegia Cerebral Palsy 45
Cerebral Palsy 36


Classifications:



External Ids:

Disease Ontology10 DOID:10970
ICD9CM29 343.2
MeSH36 D002547
ICD1027 G80.0

Summaries for Spastic Quadriplegia

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Disease Ontology:10 A spastic cerebral palsy that affects all four limbs. the individuals have difficulty with walking and talking.

MalaCards based summary: Spastic Quadriplegia, also known as spastic quadriplegic cerebral palsy, is related to mitochondrial complex ii deficiency and spastic cerebral palsy. An important gene associated with Spastic Quadriplegia is ELOVL4 (ELOVL Fatty Acid Elongase 4). Affiliated tissues include bone, skin and spinal cord.

Wikipedia:68 Spastic quadriplegia, also known as spastic tetraplegia, is a subset of spastic cerebral palsy that... more...

Related Diseases for Spastic Quadriplegia

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Diseases related to Spastic Quadriplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 438)
idRelated DiseaseScoreTop Affiliating Genes
1mitochondrial complex ii deficiency30.0SDHA, SDHAF1
2spastic cerebral palsy11.3
3mixed cerebral palsy11.1
4brain injury11.1
5encephalopathy11.0
6quadriplegia10.9
7spasticity10.9
8movement disease10.8
9prion disease10.8
10dyskinetic cerebral palsy10.8
11spastic diplegia10.8
12neuromuscular disease10.8
13myopathy10.8
14muscle disorders10.8
15muscle tissue disease10.7
16hypertonia10.7
17spastic diplegia cerebral palsy10.7
18spastic hemiplegia10.7
19neurologic diseases10.7
20hip subluxation10.7
21developmental coordination disorder10.7
22dystonia10.7
23chronic pain10.7
24hemiplegia10.6
25cerebral palsy, ataxic, autosomal recessive10.6
26ichthyosis, spastic quadriplegia, and mental retardation10.6
27developmental disabilities10.6
28periventricular leukomalacia10.6
29leukomalacia10.6
30cerebral palsy, spastic quadriplegic, 110.6
31microcephaly with spastic quadriplegia10.5
32learning disability10.5
33athetosis10.5
34spinal and bulbar muscular atrophy of kennedy10.5
35speech disorder10.5
36aplastic anemia10.5
37dysphagia10.5
38pick disease10.4
39chorioamnionitis10.4
40central nervous system disease10.4
41nervous system disease10.4
42pelizaeus-merzbacher disease10.4
43cerebritis10.4
44spastic monoplegia10.4
45bone structure disease10.4
46cerebral palsy athetoid10.4
47pain disorder10.4
48generalized dystonia10.4
49secondary syphilis10.4
50spinal cord disease10.4

Graphical network of the top 20 diseases related to Spastic Quadriplegia:



Diseases related to spastic quadriplegia

Symptoms for Spastic Quadriplegia

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Drugs & Therapeutics for Spastic Quadriplegia

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Drugs for Spastic Quadriplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BaclofenapprovedPhase 4901134-47-02284
Synonyms:
( inverted question mark)-Baclofen
(+-)-Baclofen
(+/-)- beta-(Aminoethyl)-4- chlorobenzenepropanoic acid
(+/-)-BACLOFEN
(+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
(?)-Baclofen
1134-47-0
4-Amino-3-(4-chlorophenyl)butanoic acid
4-Amino-3-(4-chlorophenyl)butyric acid
62594-36-9
AB00051921
AC-4530
AC1L1DC6
ASTA Medica Brand of Baclofen
AWD, Baclofen
Alphapharm Brand of Baclofen
Apo Baclofen
Apo-Baclofen
ApoBaclofen
Apotex Brand of Baclofen
Ashbourne Brand of Baclofen
Athena Brand of Baclofen
Atrofen
B 5399
B3343
B5399_SIGMA
BPBio1_000012
BPBio1_000750
BRD-A84174873-001-05-2
BRN 2104494
BSPBio_000010
BSPBio_001880
Ba 34647
Ba-34,647
Ba-34647
Ba34,647
Ba34647
Baclofen
Baclofen (JP15/USP/INN)
Baclofen (R,S)
Baclofen AWD
Baclofen Alphapharm Brand
Baclofen Apotex Brand
Baclofen Ashbourne Brand
Baclofen Athena Brand
Baclofen Ciba-Geigy Brand
Baclofen Irex Brand
Baclofen Isis Brand
Baclofen Medtronic Brand
Baclofen Novartis Brand
Baclofen Nu-Pharm Brand
Baclofen Pharmascience Brand
Baclofen [USAN:INN:BAN:JAN]
Baclofene
Baclofene Irex
Baclofene [INN-French]
Baclofene-Irex
BaclofeneIrex
Baclofeno
Baclofeno [INN-Spanish]
Baclofenum
Baclofenum [INN-Latin]
Baclon
Baclophen
Baclospas
Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-(9CI)
Biomol-NT_000251
C 34647Ba
C10H12ClNO2
CCRIS 3722
CHEBI:2972
CHEMBL701
CIBA-34,647-BA
CIBA34,647BA
CID2284
Chlorophenyl GABA
Ciba 34,647-Ba
Ciba Geigy Brand of Baclofen
Ciba-Geigy Brand of Baclofen
Clofen
D001418
D00241
DB00181
DL-4-Amino-3-P-chlorophenylbutanoic acid
DL-4-Amino-3-p-chlorophenylbutanoic acid
DL-Baclofen
 
DivK1c_000001
EINECS 214-486-9
EU-0100163
GABA, Chlorophenyl
Gabalon
Gablofen
Gen Baclofen
Gen-Baclofen
GenBaclofen
Genpharm
HMS1568A12
HMS1920E21
HMS2091M03
HMS500A03
I01-1934
IDI1_000001
Irex Brand of Baclofen
Isis Brand of Baclofen
KBio1_000001
KBio2_000466
KBio2_003034
KBio2_005602
KBio3_001380
KBioGR_000650
KBioSS_000466
Kemstro
Kemstro (TN)
L000002
LS-77134
Lebic
Lioresal
Lioresal (TN)
Lioresal Intrathecal
Lopac0_000163
MLS000028480
Medtronic Brand of Baclofen
MolPort-002-051-370
NCGC00015156-05
NCGC00015156-12
NCGC00023843-03
NCGC00024579-03
NCGC00024579-04
NCGC00024579-05
NCGC00024579-06
NINDS_000001
NSC329137
Novartis Brand of Baclofen
Nu Baclo
Nu Pharm Brand of Baclofen
Nu-Baclo
Nu-Baclofen
Nu-Pharm Brand of Baclofen
NuBaclo
Oprea1_440627
PCP-GABA
PMS Baclofen
PMSBaclofen
Pharmascience Brand of Baclofen
Pms-Baclofen
Prestwick0_000085
Prestwick1_000085
Prestwick2_000085
Prestwick3_000085
Prestwick_85
SMP1_000036
SMR000058294
SPBio_000044
SPBio_001949
SPECTRUM1500135
STK535284
STOCK2S-30552
Spectrum2_000092
Spectrum3_000310
Spectrum4_000245
Spectrum5_000852
Spectrum_000066
UNII-H789N3FKE8
UPCMLD-DP142
UPCMLD-DP142:001
baclofen
beta-(4-Chlorophenyl)gaba
beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
beta-(Aminomethyl)-P-chlorohydrocinnamic acid
beta-(Aminomethyl)-p-chlorohydrocinnamic acid
beta-(P-Chlorophenyl)-gamma-aminobutyric acid
beta-(p-Chlorophenyl)-gamma-aminobutyric acid
gamma-Amino-beta-(P-chlorophenyl)butyric acid
gamma-Amino-beta-(p-chlorophenyl)butyric acid
2Botulinum Toxins, Type APhase 4561
3Botulinum ToxinsPhase 4590

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4
2Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes?RecruitingNCT00752934Phase 4
3MEOPA to Improve Physical Therapy Results After Multilevel SurgeryCompletedNCT00632528Phase 3
4Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord InjuryWithdrawnNCT01569360Phase 3
5The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)Not yet recruitingNCT01349478Phase 1, Phase 2
6The Safety of ahSC in Chronic SCI With RehabilitationRecruitingNCT02354625Phase 1
7Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral PalsyCompletedNCT01815814
8Medico-economical Impact of the Brindley Neurosurgical Technique in FranceCompletedNCT00221767

Search NIH Clinical Center for Spastic Quadriplegia


Cochrane evidence based reviews: Cerebral Palsy

Genetic Tests for Spastic Quadriplegia

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Anatomical Context for Spastic Quadriplegia

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MalaCards organs/tissues related to Spastic Quadriplegia:

33
Bone, Skin, Spinal cord

Animal Models for Spastic Quadriplegia or affiliated genes

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Publications for Spastic Quadriplegia

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Articles related to Spastic Quadriplegia:

(show all 39)
idTitleAuthorsYear
1
Surgical correction of scoliosis in children with spastic quadriplegia: benefits, adverse effects, and patient selection. (24715871)
2014
2
A patient with altered consciousness and spastic quadriplegia. (21476222)
2011
3
Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia. (22100072)
2011
4
Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. (20493457)
2010
5
Alternative anesthetic management of a child with spastic quadriplegia due to metachromatic leukodystrophy using total intravenous anesthesia. (19453595)
2009
6
Etiologic profile of spastic quadriplegia in children. (18358417)
2008
7
Effect of nutritional support in children with spastic quadriplegia. (18940556)
2008
8
Proximal femoral resection and articulated hip distraction with an external fixator for the treatment of painful spastic hip dislocations in pediatric patients with spastic quadriplegia. (18043374)
2008
9
Etiologic profile of spastic quadriplegia in children. (17765809)
2007
10
Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. (18007255)
2007
11
Proximal femoral resection for subluxation or dislocation of the hip in spastic quadriplegia. (12828396)
2003
12
Progressive cerebellocerebral atrophy: a new syndrome with microcephaly, mental retardation, and spastic quadriplegia. (12920088)
2003
13
Prevalence of reduced bone mass in children and adults with spastic quadriplegia. (12549750)
2003
14
Pictorial CME. Spastic quadriplegia due to cervical cord compression. (11924575)
2002
15
Spasticity management in the child with spastic quadriplegia. (11851741)
2001
16
Resolution: a 15-year-old with spastic quadriplegia and a 60 degree scoliosis should have a posterior spinal fusion with instrumentation. The American Academy for Cerebral Palsy and Developmental Medicine 50th anniversary meeting debate. (9593501)
1998
17
Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia. (9183259)
1997
18
Monozygotic twin patients with congenital ichthyosis, microcephalus, spastic quadriplegia, myoclonus, and EEG abnormalities. (7619196)
1995
19
Changes in hip migration after selective dorsal rhizotomy for spastic quadriplegia in cerebral palsy. (7897515)
1995
20
Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. (7547458)
1995
21
Temporomandibular joint contracture in spastic quadriplegia: effect on oral-motor skills. (8005359)
1994
22
Selective intrathecal phenol block to improve activities of daily living in patients with spastic quadriplegia. A preliminary report. (7970851)
1994
23
Effect of hosiery on skin temperature in spastic quadriplegia. A preliminary study. (8040808)
1994
24
Spastic quadriplegia in Western Australia. II: Pedigrees and family patterns of birthweight and gestational age. (8462754)
1993
25
Spastic quadriplegia in Western Australia: a genetic epidemiological study. I: Case population and perinatal risk factors. (8385035)
1993
26
Decrease in gastric emptying time and episodes of regurgitation in children with spastic quadriplegia fed a whey-based formula. (1552396)
1992
27
Energy and nutrient intakes of children with spastic quadriplegia. (1960614)
1991
28
Upper extremity inhibitive casting in a boy with spastic quadriplegia. (2353723)
1990
29
Goniometric reliability for a child with spastic quadriplegia. (3998138)
1985
30
Enhancement of two motor functions of the lower extremity in a child with spastic quadriplegia. (3966079)
1985
31
Agenesis of the corpus callosum, infantile spasms, spastic quadriplegia, microcephaly and severe mental retardation in three siblings. (589850)
1977
32
Spastic quadriplegia due to electric shock. (4720779)
1973
33
Spastic quadriplegia due to electric shock. (4713989)
1973
34
Progressive spastic quadriplegia. (5978124)
1966
35
Spastic quadriplegia in a case of generalized neurofibromatosis. (4955595)
1966
36
Spastic quadriplegia combined with congenital ichthyosiform erythroderma and oligophrenia. (13594021)
1958
37
Retinitis pigmentosa, ophthalmoplegia, and spastic quadriplegia. (13394671)
1957
38
The association of congenital spastic quadriplegia and androgenic precocity in four patients. (15436558)
1950
39
Case of Spastic Quadriplegia following Injury of the Spinal Cord in the Upper Cervical Region, showing certain unusual Reflex Phenomena. (19981155)
1920

Variations for Spastic Quadriplegia

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Expression for genes affiliated with Spastic Quadriplegia

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Search GEO for disease gene expression data for Spastic Quadriplegia.

Pathways for genes affiliated with Spastic Quadriplegia

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GO Terms for genes affiliated with Spastic Quadriplegia

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Sources for Spastic Quadriplegia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet