MCID: SPS004
MIFTS: 35

Spastic Quadriplegia malady

Rare diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Spastic Quadriplegia

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A spastic cerebral palsy that affects all four limbs. the individuals have difficulty with walking and talking.

MalaCards: Spastic Quadriplegia, also known as spastic quadriplegic cerebral palsy, is related to quadriplegia and spasticity. An important gene associated with Spastic Quadriplegia is ELOVL4 (ELOVL fatty acid elongase 4). The compound glutamate have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and skin, and related mouse phenotype nervous system.

Wikipedia:65 Spastic quadriplegia, also known as spastic tetraplegia, is a subset of spastic cerebral palsy that... more...

Aliases & Classifications for Spastic Quadriplegia

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 43NIH Rare Diseases, 35MeSH, 58SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

spastic quadriplegia 8 10 45 62
spastic quadriplegic cerebral palsy 8 43
cerebral palsy, quadriplegic, infantile 62
quadriplegic infantile cerebral palsy 8
tetraplegic infantile cerebral palsy 8
spastic quadriplegia cerebral palsy 43
cerebral palsy spastic quadriplegic 43
quadriplegic spastic cerebral palsy 62
spastic tetraplegia cerebral palsy 43


External Ids:

Disease Ontology8 DOID:10970
MeSH35 D002547
ICD9CM27 343.2
ICD1025 G80.0

Related Diseases for Spastic Quadriplegia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Spastic Quadriplegia:



Diseases related to spastic quadriplegia

Symptoms for Spastic Quadriplegia

About this section

Drugs & Therapeutics for Spastic Quadriplegia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Spastic Quadriplegia

Search NIH Clinical Center for Spastic Quadriplegia

Genetic Tests for Spastic Quadriplegia

About this section

Anatomical Context for Spastic Quadriplegia

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Spastic Quadriplegia:

33
Bone, Spinal cord, Skin

Animal Models for Spastic Quadriplegia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Spastic Quadriplegia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2ARG1, PLP1, ELOVL4, TIAM1, SPTAN1

Publications for Spastic Quadriplegia

About this section
Sources:
52PubMed
See all sources

Articles related to Spastic Quadriplegia:

(show all 39)
idTitleAuthorsYear
1
Spastic quadriplegia in Down syndrome with congenital duodenal stenosis/atresia. (22639992)
2012
2
A patient with altered consciousness and spastic quadriplegia. (21476222)
2011
3
Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia. (22100072)
2011
4
Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. (20493457)
2010
5
Alternative anesthetic management of a child with spastic quadriplegia due to metachromatic leukodystrophy using total intravenous anesthesia. (19453595)
2009
6
Etiologic profile of spastic quadriplegia in children. (18358417)
2008
7
Effect of nutritional support in children with spastic quadriplegia. (18940556)
2008
8
Proximal femoral resection and articulated hip distraction with an external fixator for the treatment of painful spastic hip dislocations in pediatric patients with spastic quadriplegia. (18043374)
2008
9
Etiologic profile of spastic quadriplegia in children. (17765809)
2007
10
Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. (18007255)
2007
11
Proximal femoral resection for subluxation or dislocation of the hip in spastic quadriplegia. (12828396)
2003
12
Progressive cerebellocerebral atrophy: a new syndrome with microcephaly, mental retardation, and spastic quadriplegia. (12920088)
2003
13
Prevalence of reduced bone mass in children and adults with spastic quadriplegia. (12549750)
2003
14
Pictorial CME. Spastic quadriplegia due to cervical cord compression. (11924575)
2002
15
Spasticity management in the child with spastic quadriplegia. (11851741)
2001
16
Resolution: a 15-year-old with spastic quadriplegia and a 60 degree scoliosis should have a posterior spinal fusion with instrumentation. The American Academy for Cerebral Palsy and Developmental Medicine 50th anniversary meeting debate. (9593501)
1998
17
Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia. (9183259)
1997
18
Monozygotic twin patients with congenital ichthyosis, microcephalus, spastic quadriplegia, myoclonus, and EEG abnormalities. (7619196)
1995
19
Changes in hip migration after selective dorsal rhizotomy for spastic quadriplegia in cerebral palsy. (7897515)
1995
20
Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. (7547458)
1995
21
Temporomandibular joint contracture in spastic quadriplegia: effect on oral-motor skills. (8005359)
1994
22
Selective intrathecal phenol block to improve activities of daily living in patients with spastic quadriplegia. A preliminary report. (7970851)
1994
23
Effect of hosiery on skin temperature in spastic quadriplegia. A preliminary study. (8040808)
1994
24
Spastic quadriplegia in Western Australia. II: Pedigrees and family patterns of birthweight and gestational age. (8462754)
1993
25
Spastic quadriplegia in Western Australia: a genetic epidemiological study. I: Case population and perinatal risk factors. (8385035)
1993
26
Decrease in gastric emptying time and episodes of regurgitation in children with spastic quadriplegia fed a whey-based formula. (1552396)
1992
27
Energy and nutrient intakes of children with spastic quadriplegia. (1960614)
1991
28
Upper extremity inhibitive casting in a boy with spastic quadriplegia. (2353723)
1990
29
Goniometric reliability for a child with spastic quadriplegia. (3998138)
1985
30
Enhancement of two motor functions of the lower extremity in a child with spastic quadriplegia. (3966079)
1985
31
Agenesis of the corpus callosum, infantile spasms, spastic quadriplegia, microcephaly and severe mental retardation in three siblings. (589850)
1977
32
Spastic quadriplegia due to electric shock. (4720779)
1973
33
Spastic quadriplegia due to electric shock. (4713989)
1973
34
Progressive spastic quadriplegia. (5978124)
1966
35
Spastic quadriplegia in a case of generalized neurofibromatosis. (4955595)
1966
36
Spastic quadriplegia combined with congenital ichthyosiform erythroderma and oligophrenia. (13594021)
1958
37
Retinitis pigmentosa, ophthalmoplegia, and spastic quadriplegia. (13394671)
1957
38
The association of congenital spastic quadriplegia and androgenic precocity in four patients. (15436558)
1950
39
Case of Spastic Quadriplegia following Injury of the Spinal Cord in the Upper Cervical Region, showing certain unusual Reflex Phenomena. (19981155)
1920

Variations for Spastic Quadriplegia

About this section

Expression for genes affiliated with Spastic Quadriplegia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spastic Quadriplegia

Search GEO for disease gene expression data for Spastic Quadriplegia.

Pathways for genes affiliated with Spastic Quadriplegia

About this section

Compounds for genes affiliated with Spastic Quadriplegia

About this section
Sources:
45Novoseek
See all sources

Compounds related to Spastic Quadriplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate458.6ARG1, PLP1, TIAM1, SPTAN1

GO Terms for genes affiliated with Spastic Quadriplegia

About this section

Products for genes affiliated with Spastic Quadriplegia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spastic Quadriplegia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet