MCID: SPS004
MIFTS: 35

Spastic Quadriplegia malady

Rare diseases, Neuronal diseases categories

Summaries for Spastic Quadriplegia

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A spastic cerebral palsy that affects all four limbs. the individuals have difficulty with walking and talking.

MalaCards: Spastic Quadriplegia, also known as spastic quadriplegic cerebral palsy, is related to quadriplegia and spasticity. An important gene associated with Spastic Quadriplegia is ELOVL4 (ELOVL fatty acid elongase 4). The compound glutamate have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and skin, and related mouse phenotype nervous system.

Wikipedia:66 Spastic quadriplegia, also known as spastic tetraplegia, is a subset of spastic cerebral palsy that... more...

Aliases & Classifications for Spastic Quadriplegia

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 44NIH Rare Diseases, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

spastic quadriplegia 9 11 46 63
spastic quadriplegic cerebral palsy 9 44
cerebral palsy, quadriplegic, infantile 63
quadriplegic infantile cerebral palsy 9
tetraplegic infantile cerebral palsy 9
spastic quadriplegia cerebral palsy 44
cerebral palsy spastic quadriplegic 44
quadriplegic spastic cerebral palsy 63
spastic tetraplegia cerebral palsy 44


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Disease Ontology9 DOID:10970
MeSH36 D002547
ICD9CM28 343.2
ICD1026 G80.0

Related Diseases for Spastic Quadriplegia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Spastic Quadriplegia:



Diseases related to spastic quadriplegia

Symptoms for Spastic Quadriplegia

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Drugs & Therapeutics for Spastic Quadriplegia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spastic Quadriplegia

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Anatomical Context for Spastic Quadriplegia

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34MalaCards
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MalaCards organs/tissues related to Spastic Quadriplegia:

34
Bone, Spinal cord, Skin

Animal Models for Spastic Quadriplegia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Spastic Quadriplegia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2ARG1, PLP1, ELOVL4, TIAM1, SPTAN1

Publications for Spastic Quadriplegia

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53PubMed
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Articles related to Spastic Quadriplegia:

(show all 39)
idTitleAuthorsYear
1
Spastic quadriplegia in Down syndrome with congenital duodenal stenosis/atresia. (22639992)
2012
2
A patient with altered consciousness and spastic quadriplegia. (21476222)
2011
3
Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia. (22100072)
2011
4
Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. (20493457)
2010
5
Alternative anesthetic management of a child with spastic quadriplegia due to metachromatic leukodystrophy using total intravenous anesthesia. (19453595)
2009
6
Etiologic profile of spastic quadriplegia in children. (18358417)
2008
7
Effect of nutritional support in children with spastic quadriplegia. (18940556)
2008
8
Proximal femoral resection and articulated hip distraction with an external fixator for the treatment of painful spastic hip dislocations in pediatric patients with spastic quadriplegia. (18043374)
2008
9
Etiologic profile of spastic quadriplegia in children. (17765809)
2007
10
Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. (18007255)
2007
11
Proximal femoral resection for subluxation or dislocation of the hip in spastic quadriplegia. (12828396)
2003
12
Progressive cerebellocerebral atrophy: a new syndrome with microcephaly, mental retardation, and spastic quadriplegia. (12920088)
2003
13
Prevalence of reduced bone mass in children and adults with spastic quadriplegia. (12549750)
2003
14
Pictorial CME. Spastic quadriplegia due to cervical cord compression. (11924575)
2002
15
Spasticity management in the child with spastic quadriplegia. (11851741)
2001
16
Resolution: a 15-year-old with spastic quadriplegia and a 60 degree scoliosis should have a posterior spinal fusion with instrumentation. The American Academy for Cerebral Palsy and Developmental Medicine 50th anniversary meeting debate. (9593501)
1998
17
Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia. (9183259)
1997
18
Monozygotic twin patients with congenital ichthyosis, microcephalus, spastic quadriplegia, myoclonus, and EEG abnormalities. (7619196)
1995
19
Changes in hip migration after selective dorsal rhizotomy for spastic quadriplegia in cerebral palsy. (7897515)
1995
20
Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. (7547458)
1995
21
Temporomandibular joint contracture in spastic quadriplegia: effect on oral-motor skills. (8005359)
1994
22
Selective intrathecal phenol block to improve activities of daily living in patients with spastic quadriplegia. A preliminary report. (7970851)
1994
23
Effect of hosiery on skin temperature in spastic quadriplegia. A preliminary study. (8040808)
1994
24
Spastic quadriplegia in Western Australia. II: Pedigrees and family patterns of birthweight and gestational age. (8462754)
1993
25
Spastic quadriplegia in Western Australia: a genetic epidemiological study. I: Case population and perinatal risk factors. (8385035)
1993
26
Decrease in gastric emptying time and episodes of regurgitation in children with spastic quadriplegia fed a whey-based formula. (1552396)
1992
27
Energy and nutrient intakes of children with spastic quadriplegia. (1960614)
1991
28
Upper extremity inhibitive casting in a boy with spastic quadriplegia. (2353723)
1990
29
Goniometric reliability for a child with spastic quadriplegia. (3998138)
1985
30
Enhancement of two motor functions of the lower extremity in a child with spastic quadriplegia. (3966079)
1985
31
Agenesis of the corpus callosum, infantile spasms, spastic quadriplegia, microcephaly and severe mental retardation in three siblings. (589850)
1977
32
Spastic quadriplegia due to electric shock. (4720779)
1973
33
Spastic quadriplegia due to electric shock. (4713989)
1973
34
Progressive spastic quadriplegia. (5978124)
1966
35
Spastic quadriplegia in a case of generalized neurofibromatosis. (4955595)
1966
36
Spastic quadriplegia combined with congenital ichthyosiform erythroderma and oligophrenia. (13594021)
1958
37
Retinitis pigmentosa, ophthalmoplegia, and spastic quadriplegia. (13394671)
1957
38
The association of congenital spastic quadriplegia and androgenic precocity in four patients. (15436558)
1950
39
Case of Spastic Quadriplegia following Injury of the Spinal Cord in the Upper Cervical Region, showing certain unusual Reflex Phenomena. (19981155)
1920

Variations for Spastic Quadriplegia

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Expression for genes affiliated with Spastic Quadriplegia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spastic Quadriplegia

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Pathways for genes affiliated with Spastic Quadriplegia

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Compounds for genes affiliated with Spastic Quadriplegia

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46Novoseek
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Compounds related to Spastic Quadriplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate468.6ARG1, PLP1, TIAM1, SPTAN1

GO Terms for genes affiliated with Spastic Quadriplegia

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Products for genes affiliated with Spastic Quadriplegia

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Sources for Spastic Quadriplegia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet