MCID: SPS057
MIFTS: 29

Spasticity malady

Summaries for Spasticity

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might

MalaCards: Spasticity is related to paraplegia and cerebral palsy. An important gene associated with Spasticity is SPAST (spastin). Affiliated tissues include skeletal muscle, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:63 Spasticity or hyperreflexia is a feature of altered skeletal muscle performance in muscle tone involving... more...

Aliases & Classifications for Spasticity

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43NINDS
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Aliases & Descriptions:

spasticity 43


Related Diseases for Spasticity

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17GeneCards, 18GeneDecks
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Diseases related to Spasticity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 648)
idRelated DiseaseScoreTop Affiliating Genes
1paraplegia31.6AP4B1, FA2H, NIPA1, ATL1, PLP1, KIF5A
2cerebral palsy31.5PLP1
3hereditary spastic paraplegia31.5SPAST, HSPD1, NIPA1, ATL1, PLP1, KIF5A
4multiple sclerosis30.9PLP1, HSPD1
5neuropathy30.7SACS
6spastic paraplegia 3a30.6ATL1, SPAST
7intellectual disability30.1L1CAM
8motor neuron disease30.1SPAST
9leukodystrophy29.9FA2H, PLP1
10opa3-related 3-methylglutaconic aciduria29.5SPG7
11cerebritis11.0
12spastic cerebral palsy11.0
13tropical spastic paraparesis11.0
14spastic diplegia10.8
15spastic hemiplegia10.7
16hemiplegia10.7
17spastic quadriplegia10.6
18quadriplegia10.5
19spastic paraplegia 1110.5
20arsacs10.5
21leukemia10.5
22t-cell leukemia10.4
23spastic paraplegia 410.4
24spastic paraplegia 710.4
25infantile-onset ascending hereditary spastic paralysis10.4
26spastic paraplegia 810.4
27spastic entropion10.4
28neuronitis10.4
29entropion10.4
30troyer syndrome10.3
31spastic paraplegia 1710.3
32spastic paraplegia 210.3
33alzheimer's disease10.3
34lateral sclerosis10.3
35spastic paraplegia 1510.3
36spastic paraplegia 110.3
37spastic monoplegia10.3
38spastic paraplegia 2, x-linked10.2
39microcephaly10.2
40optic atrophy10.2
41hereditary ataxia10.2
42cerebral palsy, spastic quadriplegic, 110.2
43spastic paraplegia 3a, autosomal dominant10.2
44adult t-cell leukemia10.2
45amyotrophic lateral sclerosis10.2
46cerebellar ataxia10.2
47keratoderma palmoplantar spastic paralysis10.2
48familial spastic paralysis10.2
49spastic paraplegia 39, autosomal recessive10.2
50peripheral neuropathy10.2

Graphical network of the top 20 diseases related to Spasticity:



Diseases related to spasticity

Clinical Features for Spasticity

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Drugs & Therapeutics for Spasticity

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spasticity

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Anatomical Context for Spasticity

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32MalaCards
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MalaCards organs/tissues related to Spasticity:

32
Skeletal muscle

Animal Models for Spasticity or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spasticity:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.4AP4B1, FA2H, PLP1, KIF1A, KIF5A, SPG20
2MP:000538611.2SPAST, L1CAM, AP4B1, FA2H, ATL1, PLP1

Publications for Spasticity

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Genetic Variations for Spasticity

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Expression for genes affiliated with Spasticity

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spasticity

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Pathways for genes affiliated with Spasticity

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Compounds for genes affiliated with Spasticity

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GO Terms for genes affiliated with Spasticity

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16Gene Ontology
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Cellular components related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1midbodyGO:03049610.8SPAST, SPG20, ZFYVE26

Biological processes related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821912.1L1CAM, KIF1A, PLP1, ZFYVE26, CYP2U1, ATL1
2anterograde axon cargo transportGO:00808910.7KIF1A, SPG7

Molecular functions related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:00801710.8SPAST, KIF5A, KIF1A

Products for genes affiliated with Spasticity

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spasticity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet