Aliases & Classifications for Spasticity

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Spasticity, Aliases & Descriptions:

Name: Spasticity 42


Summaries for Spasticity

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NINDS:42 Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might

MalaCards based summary: Spasticity is related to paraplegia and west syndrome. An important gene associated with Spasticity is SACS (sacsin molecular chaperone). Affiliated tissues include t cells, spinal cord and brain.

Wikipedia:63 Spasticity (from Greek spasmos-, meaning \"drawing, pulling\") is a feature of altered skeletal muscle... more...

Related Diseases for Spasticity

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Diseases related to Spasticity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 849)
idRelated DiseaseScoreTop Affiliating Genes
1paraplegia31.6KIAA0196, AP4B1
2west syndrome29.6ARX, MECP2
3brain disease29.3ARX, MECP2
4spastic paraparesis11.1
5cerebritis11.1
6cerebral palsy11.1
7hereditary spastic paraplegia11.1
8spastic cerebral palsy11.0
9tropical spastic paraparesis11.0
10spastic diplegia10.9
11spastic hemiplegia10.8
12hemiplegia10.7
13ataxia10.7
14spastic quadriplegia10.6
15hypertonia10.6
16spinal cord injury10.6
17neuropathy10.6
18quadriplegia10.5
19troyer syndrome10.5
20spastic paraplegia 1110.5
21leukemia10.5
22htlv-1 associated myelopathy/tropical spastic paraparesis10.5
23t-cell leukemia10.5
24arsacs10.5
25spastic paraplegia 710.5
26spastic paraplegia 210.5
27htlv-1 associated myelopathy10.5
28infantile-onset ascending hereditary spastic paralysis10.5
29spastic paraplegia 3a10.5
30spastic paraplegia 1510.4
31spastic paraplegia 810.4
32mental retardation10.4
33spastic paraplegia 410.4
34neuronitis10.4
35spastic entropion10.4
36blindness10.4
37masa syndrome10.4
38dystonia10.4
39entropion10.4
40spastic paraplegia 1710.4
41ataxia, spastic, 410.4
42spastic paraplegia 35, autosomal recessive10.3
43spastic paraplegia 3a, autosomal dominant10.3
44lateral sclerosis10.3
45cerebral palsy, spastic quadriplegic, 110.3
46spastic paraplegia 39, autosomal recessive10.3
47brain injury10.3
48spastic paraplegia 10, autosomal dominant10.3
49spastic diplegia cerebral palsy10.3
50spastic paraplegia 30, autosomal recessive10.3

Graphical network of the top 20 diseases related to Spasticity:



Diseases related to spasticity

Symptoms for Spasticity

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Drugs & Therapeutics for Spasticity

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Drug clinical trials:

Search ClinicalTrials for Spasticity

Search NIH Clinical Center for Spasticity

Genetic Tests for Spasticity

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Anatomical Context for Spasticity

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MalaCards organs/tissues related to Spasticity:

31
T cells, Spinal cord, Brain, Testes, Skeletal muscle, Bone, Heart, Endothelial, Eye, Cortex, Colon, Skin, Nk cells, B cells, Dorsal root ganglion, Thymus, Cerebellum, Kidney, Thyroid, Temporal lobe, Amygdala, Tongue, Appendix

Animal Models for Spasticity or affiliated genes

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Publications for Spasticity

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Articles related to Spasticity:

(show top 50)    (show all 2818)
idTitleAuthorsYear
1
Functional hindrance due to spasticity in individuals with spinal cord injury during inpatient rehabilitation and 1 year thereafter. (25777334)
2015
2
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. (25229227)
2014
3
A complex form of hereditary spastic paraplegia in three siblings due to somatic mosaicism for a novel SPAST mutation in the mother. (25315759)
2014
4
Effect of repetitive transcranial magnetic stimulation on reducing spasticity in patients suffering from HTLV-1-associated myelopathy. (25462141)
2014
5
Can a lifestyle intervention improve physical fitness in adolescents and young adults with spastic cerebral palsy? A randomized controlled trial. (25067790)
2014
6
Stimulus point distribution in deep or superficial peroneal nerve for treatment of ankle spasticity. (23009065)
2013
7
Multiple sclerosis spasticity: 'state-of-the-art' questionnaire survey of specialized healthcare professionals. (23369056)
2013
8
Spasticity after stroke: physiology, assessment and treatment. (23885710)
2013
9
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. (24051375)
2013
10
Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patients. (23885344)
2013
11
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
12
Sensory feedback to ankle plantar flexors is not exaggerated during gait in spastic children with cerebral palsy. (24225545)
2013
13
Revisiting physiologic and psychologic triggers that increase spasticity. (23620900)
2013
14
Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3. (23975261)
2013
15
Poststroke spasticity: Treating to the disability. (23437441)
2013
16
Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up. (23869330)
2013
17
Identification of a novel homozygous SPG7 mutation in a Japanese patient with spastic ataxia: making an efficient diagnosis using exome sequencing for autosomal recessive cerebellar ataxia and spastic paraplegia. (23857099)
2013
18
Hip flexion deformity improves without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia. (22878968)
2012
19
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
20
Botulinum toxin type A in the healing of chronic lesion following bilateral spasticity of gluteus muscle. (23078619)
2012
21
Outcomes of correction of internal hip rotation in patients with spastic cerebral palsy using proximal femoral osteotomy. (22425638)
2012
22
Cerebellar cognitive affective syndrome and autosomal recessive spastic ataxia of charlevoix-saguenay: a report of two male sibs. (22441213)
2012
23
Commentary on an article by Pamela Thomason, BPhty, MPT, et al.: "Single-event multilevel surgery in children with spastic diplegia. A pilot randomized controlled trial". (21368072)
2011
24
Bladder dysfunction in hereditary spastic paraplegia: what to expect? (19726407)
2010
25
Upper limb spasticity reduction following active training: a robot-mediated study in patients with chronic hemiparesis. (20411224)
2010
26
Botulinum toxin to treat upper-limb spasticity in hemiparetic patients: analysis of function and kinematics of reaching movements. (20067949)
2010
27
Long-term treatment of spasticity with botulinum toxin type A: an analysis of 1221 treatments in 137 patients. (19726016)
2010
28
Hereditary spastic paraplegia and amyotrophy associated with a novel locus on chromosome 19. (20039086)
2010
29
Surgical management of spasticity in persons with cerebral palsy. (19769917)
2009
30
New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP). (19034539)
2009
31
Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia. (19917823)
2009
32
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
33
Eight novel mutations in SPG4 in a large sample of patients with hereditary spastic paraplegia. (16682546)
2006
34
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
35
Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum? (16036421)
2005
36
A novel NIPA1 mutation associated with a pure form of autosomal dominant hereditary spastic paraplegia. (15711826)
2005
37
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)
2004
38
Gait analysis of sporadic and hereditary spastic paraplegia. (15164190)
2004
39
Private SACS mutations in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) families from Turkey. (15156359)
2004
40
The characteristics of sit-to-stand transfer in young children with spastic cerebral palsy based on kinematic and kinetic data. (12535725)
2003
41
Three novel spastin (SPG4) mutations in families with autosomal dominant hereditary spastic paraplegia. (12163196)
2002
42
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
43
Motor evoked potentials from the external anal sphincter in patients with autosomal dominant pure spastic paraplegia linked to chromosome 2p. (11561054)
2001
44
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
45
Stance balance control with orthoses in a group of children with spastic cerebral palsy. (10576639)
1999
46
Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q. (9973294)
1999
47
Spastic paraparesis in alcoholic cirrhosis with portal systemic encephalopathy. (11273332)
1998
48
Autosomal dominant familial spastic paraplegia: reduction of the FSP1 candidate region on chromosome 14q to 7 cM and locus heterogeneity. (7825576)
1995
49
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
50
Spastic entropion correction; Wheeler's orbicularis advancement. (18114398)
1949

Variations for Spasticity

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Expression for genes affiliated with Spasticity

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Search GEO for disease gene expression data for Spasticity.

Pathways for genes affiliated with Spasticity

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Compounds for genes affiliated with Spasticity

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GO Terms for genes affiliated with Spasticity

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Biological processes related to Spasticity according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00082198.9KIAA0196, SACS, C19orf12, GBA2

Products for genes affiliated with Spasticity

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  • Antibodies
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Sources for Spasticity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet