MCID: SPS057
MIFTS: 42

Spasticity malady

Summaries for Spasticity

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might

MalaCards: Spasticity is related to hereditary spastic paraplegia and mental retardation. An important gene associated with Spasticity is SPAST (spastin). Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:64 Spasticity is a feature of altered skeletal muscle performance in muscle tone involving hypertonia; it... more...

Aliases & Classifications for Spasticity

Sources:
44NINDS
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Aliases & Descriptions:

spasticity 44


Related Diseases for Spasticity

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Spasticity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 671)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary spastic paraplegia31.5SPAST, SPG7, SPG20, KIF5A, HSPD1, NIPA1
2mental retardation30.6SPAST, L1CAM
3spastic paraplegia 3a30.6SPAST, ATL1
4opa3-related 3-methylglutaconic aciduria29.5SPG7
5spastic paraparesis11.1
6spastic cerebral palsy11.0
7tropical spastic paraparesis11.0
8spastic diplegia10.8
9spastic hemiplegia10.7
10ataxia10.7
11spastic quadriplegia10.6
12hypertonia10.5
13spinal cord injury10.5
14quadriplegia10.5
15spastic paraplegia 1110.5
16arsacs10.5
17spastic paraplegia 110.5
18t-cell leukemia10.5
19infantile-onset ascending hereditary spastic paralysis10.4
20spastic paraplegia 810.4
21spastic entropion10.4
22spastic paraplegia 710.4
23spastic paraplegia 410.4
24spastic paraplegia 210.4
25alzheimer's disease10.4
26troyer syndrome10.4
27spastic diplegia cerebral palsy10.4
28spastic paraplegia 1710.3
29lateral sclerosis10.3
30n syndrome10.3
31spastic monoplegia10.3
32microcephaly10.2
33hereditary ataxia10.2
34neuropathy sensory spastic paraplegia10.2
35cerebral palsy, spastic quadriplegic, 110.2
36familial spastic paralysis10.2
37spastic paraplegia 2, x-linked10.2
38adult t-cell leukemia10.2
39amyotrophic lateral sclerosis10.2
40spastic paraplegia 5110.2
41keratoderma palmoplantar spastic paralysis10.2
42spastic paraplegia 1510.2
43brain injury10.2
44spastic paraplegia 3a, autosomal dominant10.2
45pelizaeus-merzbacher disease10.2
46friedreich ataxia10.2
47spastic paraplegia 1010.2
48autosomal recessive spastic ataxia 410.2
49htlv-1 associated myelopathy/tropical spastic paraparesis10.2
50spastic ataxia 1, autosomal dominant10.2

Graphical network of the top 20 diseases related to Spasticity:



Diseases related to spasticity

Clinical Features for Spasticity

Drugs & Therapeutics for Spasticity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Spasticity

Drug clinical trials:

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Search NIH Clinical Center for Spasticity

Search CenterWatch for Spasticity

Genetic Tests for Spasticity

Anatomical Context for Spasticity

Sources:
33MalaCards
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MalaCards organs/tissues related to Spasticity:

33
Whole blood, Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Nk cells, T cells, Fetal brain, Dorsal root ganglion

Animal Models for Spasticity or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Spasticity:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.4AP4B1, FA2H, PLP1, KIF1A, KIF5A, SPG20
2MP:000538611.2SPAST, L1CAM, AP4B1, FA2H, ATL1, PLP1

Publications for Spasticity

Sources:
51PubMed
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Articles related to Spasticity:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury. (24216616)
2014
2
Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. (24121462)
2014
3
The early use of botulinum toxin in post-stroke spasticity: study protocol for a randomised controlled trial. (24401159)
2014
4
Efficacy and safety of botulinum toxin type A (Dysport) for the treatment of post-stroke arm spasticity: Results of the German-Austrian open-label post-marketing surveillance prospective study. (24361062)
2013
5
Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS). (23595882)
2013
6
Systematic review of upper-limb function measurement methods in botulinum toxin intervention for focal spasticity. (23630050)
2013
7
A randomized controlled trial of surface neuromuscular electrical stimulation applied early after acute stroke: effects on wrist pain, spasticity and contractures. (23129814)
2013
8
Group exercise training for balance, functional status, spasticity, fatigue and quality of life in multiple sclerosis: a randomized controlled trial. (23543341)
2013
9
Usefulness of radial extracorporeal shock wave therapy for the spasticity of the subscapularis in patients with stroke: a pilot study. (24342303)
2013
10
Retrospective Study of the Investigations of Children Presenting with Lower Limbs Spasticity in a Single Institution. (24363206)
2013
11
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
12
Botulinum toxin type A in the healing of chronic lesion following bilateral spasticity of gluteus muscle. (23078619)
2012
13
Intrathecal baclofen therapy for severe spasticity: analysis on a series of 112 consecutive patients and future prospectives. (22104692)
2012
14
Understanding spasticity from patients' perspectives over time. (22339651)
2012
15
Functional influence of botulinum neurotoxin type A treatment (XeominAr) of multifocal upper and lower limb spasticity on chronic hemiparetic gait. (23139852)
2012
16
Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: a 1-year follow-up prospective study. (22571286)
2012
17
Spasticity following spinal cord injury. (22562332)
2012
18
Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries. (23204875)
2012
19
Treatment of upper limb spasticity after stroke: one-year safety and efficacy of botulinum toxin type A NT201. (22652163)
2012
20
Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity. (22509985)
2012
21
Botulinum toxin treatment in upper limb spasticity: treatment consistency. (21862370)
2012
22
Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis. (22928118)
2012
23
The effects of Robotic-Assisted Locomotor training on spasticity and volitional control. (22275643)
2011
24
Investigating muscle selection for botulinum toxin-A injections in adults with post-stroke upper limb spasticity. (22031350)
2011
25
The contribution of spasticity to the movement disorder of cerebral palsy using pathway analysis: does spasticity matter? (21171216)
2011
26
Decrease of spasticity with muscle vibration in patients with spinal cord injury. (21172739)
2011
27
Poststroke chronic disease management: towards improved identification and interventions for poststroke spasticity-related complications. (21205240)
2011
28
Portable measurement system for the objective evaluation of the spasticity of hemiplegic patients based on the tonic stretch reflex threshold. (20932794)
2011
29
Causal relation between spasticity, strength, gross motor function, and functional outcome in children with cerebral palsy: a path analysis. (21126242)
2011
30
Spasticity and electrophysiologic changes after extracorporeal shock wave therapy on gastrocnemius. (22506181)
2011
31
Rehabilitation techniques to maximize spasticity management. (21642058)
2011
32
Clinical measurement of limb spasticity in adults: state of the science. (21488584)
2011
33
Reliability of the Tardieu Scale for assessing spasticity in children with cerebral palsy. (20298834)
2010
34
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. (20190766)
2010
35
Role of cannabinoids in the treatment of pain and (painful) spasticity. (21142261)
2010
36
Efficacy and safety of NT 201 for upper limb spasticity of various etiologies--a randomized parallel-group study. (20456248)
2010
37
The role of kinesiotaping combined with botulinum toxin to reduce plantar flexors spasticity after stroke. (20826420)
2010
38
Walking speed modifies spasticity effects in gastrocnemius and soleus in cerebral palsy gait. (19349103)
2009
39
Constraint-induced movement therapy after injection of Botulinum toxin improves spasticity and motor function in chronic stroke patients. (19929775)
2009
40
Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review. (19961570)
2009
41
Effectiveness of riluzole in suppressing spasticity in the spinal cord injured rat. (19368865)
2009
42
Intrathecal ziconotide and baclofen provide pain relief in seven patients with neuropathic pain and spasticity: case reports. (19156022)
2009
43
Spasticity, an impairment that is poorly defined and poorly measured. (19470550)
2009
44
Botulinum neurotoxin type A injections reduce spasticity in mild to moderate hereditary spastic paraplegia--report of 19 cases. (17999430)
2008
45
Reliability and sensitivity of a wrist rig to measure motor control and spasticity in poststroke hemiplegia. (18776066)
2008
46
Spasticity in a child with myelomeningocele treated with continuous intrathecal baclofen. (12944705)
2003
47
Changes in ankle spasticity and strength following selective dorsal rhizotomy and physical therapy for spastic cerebral palsy. (10541227)
1999
48
X-linked microcephaly, microphthalmia, microcornea, congenital cataract, hypogenitalism, mental deficiency, growth retardation, spasticity: possible new syndrome. (8958326)
1996
49
Chorea with prominent spasticity associated with an expansion of the CAG trinucleotide repeat in the IT15 gene: a case report]. (8720339)
1995
50
Segmental reflex pathways in spinal shock and spinal spasticity in man. (4375172)
1974

Genetic Variations for Spasticity

Expression for genes affiliated with Spasticity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spasticity

Search GEO for disease gene expression data for Spasticity.

Pathways for genes affiliated with Spasticity

Compounds for genes affiliated with Spasticity

GO Terms for genes affiliated with Spasticity

Sources:
16Gene Ontology
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Cellular components related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1midbodyGO:03049610.8SPAST, SPG20, ZFYVE26

Biological processes related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821912.1L1CAM, KIF1A, PLP1, ZFYVE26, CYP2U1, ATL1
2anterograde axon cargo transportGO:00808910.7KIF1A, SPG7

Molecular functions related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:00801710.8SPAST, KIF5A, KIF1A

Products for genes affiliated with Spasticity

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Sources for Spasticity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet