MCID: SPS057
MIFTS: 37

Spasticity malady

Download this MalaCard

Summaries for Spasticity

About this section
Sources:
44NINDS, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
NINDS:44 Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might

MalaCards: Spasticity is related to paraplegia and intellectual disability. An important gene associated with Spasticity is SACS (sacsin molecular chaperone). Affiliated tissues include t cells, spinal cord and brain.

Wikipedia:65 Spasticity is a feature of altered skeletal muscle performance in muscle tone involving hypertonia; it... more...

Aliases & Classifications for Spasticity

About this section
Sources:
44NINDS
See all sources

Aliases & Descriptions:

spasticity 44


Related Diseases for Spasticity

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Spasticity:



Diseases related to spasticity

Symptoms for Spasticity

About this section

Drugs & Therapeutics for Spasticity

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Spasticity

Search NIH Clinical Center for Spasticity

Genetic Tests for Spasticity

About this section

Anatomical Context for Spasticity

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Spasticity:

33
T cells, Spinal cord, Brain, Skeletal muscle, Testes, Bone, Endothelial, Heart, Dorsal root ganglion, Colon, Skin, Cortex, Nk cells, Amygdala, Temporal lobe, Tongue, Eye, B cells, Thyroid, Kidney, Cerebellum, Thymus, Appendix

Animal Models for Spasticity or affiliated genes

About this section

Publications for Spasticity

About this section
Sources:
52PubMed
See all sources

Articles related to Spasticity:

(show top 50)    (show all 2622)
idTitleAuthorsYear
1
Stimulus point distribution in deep or superficial peroneal nerve for treatment of ankle spasticity. (23009065)
2013
2
Multiple sclerosis spasticity: 'state-of-the-art' questionnaire survey of specialized healthcare professionals. (23369056)
2013
3
Spasticity after stroke: physiology, assessment and treatment. (23885710)
2013
4
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. (24051375)
2013
5
Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patients. (23885344)
2013
6
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
7
Sensory feedback to ankle plantar flexors is not exaggerated during gait in spastic children with cerebral palsy. (24225545)
2013
8
Revisiting physiologic and psychologic triggers that increase spasticity. (23620900)
2013
9
Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3. (23975261)
2013
10
Poststroke spasticity: Treating to the disability. (23437441)
2013
11
Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up. (23869330)
2013
12
Hip flexion deformity improves without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia. (22878968)
2012
13
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
14
Visual impairment in children with spastic cerebral palsy measured by psychophysical and electrophysiological grating acuity tests. (23030659)
2012
15
Botulinum toxin type A in the healing of chronic lesion following bilateral spasticity of gluteus muscle. (23078619)
2012
16
Outcomes of correction of internal hip rotation in patients with spastic cerebral palsy using proximal femoral osteotomy. (22425638)
2012
17
Cerebellar cognitive affective syndrome and autosomal recessive spastic ataxia of charlevoix-saguenay: a report of two male sibs. (22441213)
2012
18
A comparison of activity, participation and quality of life in children with and without spastic diplegia cerebral palsy. (22200241)
2012
19
Commentary on an article by Pamela Thomason, BPhty, MPT, et al.: "Single-event multilevel surgery in children with spastic diplegia. A pilot randomized controlled trial". (21368072)
2011
20
Bladder dysfunction in hereditary spastic paraplegia: what to expect? (19726407)
2010
21
Upper limb spasticity reduction following active training: a robot-mediated study in patients with chronic hemiparesis. (20411224)
2010
22
Botulinum toxin to treat upper-limb spasticity in hemiparetic patients: analysis of function and kinematics of reaching movements. (20067949)
2010
23
Long-term treatment of spasticity with botulinum toxin type A: an analysis of 1221 treatments in 137 patients. (19726016)
2010
24
Hereditary spastic paraplegia and amyotrophy associated with a novel locus on chromosome 19. (20039086)
2010
25
Surgical management of spasticity in persons with cerebral palsy. (19769917)
2009
26
New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP). (19034539)
2009
27
Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia. (19917823)
2009
28
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
29
A MELAS-associated ND1 mutation causing leber hereditary optic neuropathy and spastic dystonia. (17562939)
2007
30
Eight novel mutations in SPG4 in a large sample of patients with hereditary spastic paraplegia. (16682546)
2006
31
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
32
Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum? (16036421)
2005
33
A novel NIPA1 mutation associated with a pure form of autosomal dominant hereditary spastic paraplegia. (15711826)
2005
34
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)
2004
35
Gait analysis of sporadic and hereditary spastic paraplegia. (15164190)
2004
36
Private SACS mutations in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) families from Turkey. (15156359)
2004
37
Three novel spastin (SPG4) mutations in families with autosomal dominant hereditary spastic paraplegia. (12163196)
2002
38
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
39
Early mobilization after sliding achilles tendon lengthening in children with spastic cerebral palsy. (11139029)
2000
40
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
41
Stance balance control with orthoses in a group of children with spastic cerebral palsy. (10576639)
1999
42
Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q. (9973294)
1999
43
A fine integrated map of the SPG4 locus excludes an expanded CAG repeat in chromosome 2p-linked autosomal dominant spastic paraplegia. (10493830)
1999
44
Spastic paraparesis in alcoholic cirrhosis with portal systemic encephalopathy. (11273332)
1998
45
A male child with the rumpshaker mutation, X-linked spastic paraplegia/Pelizaeus-Merzbacher disease and lysinuria. (9427151)
1997
46
Autosomal dominant familial spastic paraplegia: reduction of the FSP1 candidate region on chromosome 14q to 7 cM and locus heterogeneity. (7825576)
1995
47
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
48
Spastic hypertonia: mechanisms and measurement. (2644919)
1989
49
Tropical spastic paraparesis: lack of human T-lymphotropic virus type I antibodies in blood donors from Bogota, Colombia. (2829802)
1988
50
Spastic entropion correction; Wheeler's orbicularis advancement. (18114398)
1949

Variations for Spasticity

About this section

Expression for genes affiliated with Spasticity

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spasticity

Search GEO for disease gene expression data for Spasticity.

Pathways for genes affiliated with Spasticity

About this section

Compounds for genes affiliated with Spasticity

About this section

GO Terms for genes affiliated with Spasticity

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082198.9KIAA0196, SACS, C19orf12, GBA2

Products for genes affiliated with Spasticity

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spasticity

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet