MCID: SPS057
MIFTS: 38

Spasticity malady

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Summaries for Spasticity

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NINDS:43 Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might

MalaCards based summary: Spasticity is related to paraplegia and spastic paraparesis. An important gene associated with Spasticity is SACS (sacsin molecular chaperone). Affiliated tissues include t cells, spinal cord and brain.

Wikipedia:65 Spasticity (from Greek spasmos-, meaning \"drawing, pulling\") is a feature of altered skeletal muscle... more...

Aliases & Classifications for Spasticity

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Spasticity, Aliases & Descriptions:

Name: Spasticity 43


Related Diseases for Spasticity

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Graphical network of the top 20 diseases related to Spasticity:



Diseases related to spasticity

Symptoms for Spasticity

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Drugs & Therapeutics for Spasticity

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Drug clinical trials:

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Genetic Tests for Spasticity

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Anatomical Context for Spasticity

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MalaCards organs/tissues related to Spasticity:

32
T cells, Spinal cord, Brain, Testes, Skeletal muscle, Bone, Heart, Endothelial, Eye, Cortex, Colon, Skin, Nk cells, B cells, Dorsal root ganglion, Thymus, Cerebellum, Kidney, Thyroid, Temporal lobe, Amygdala, Tongue, Appendix

Animal Models for Spasticity or affiliated genes

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Publications for Spasticity

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Articles related to Spasticity:

(show top 50)    (show all 2742)
idTitleAuthorsYear
1
A complex form of hereditary spastic paraplegia in three siblings due to somatic mosaicism for a novel SPAST mutation in the mother. (25315759)
2014
2
Can a lifestyle intervention improve physical fitness in adolescents and young adults with spastic cerebral palsy? A randomized controlled trial. (25067790)
2014
3
Stimulus point distribution in deep or superficial peroneal nerve for treatment of ankle spasticity. (23009065)
2013
4
Multiple sclerosis spasticity: 'state-of-the-art' questionnaire survey of specialized healthcare professionals. (23369056)
2013
5
Spasticity after stroke: physiology, assessment and treatment. (23885710)
2013
6
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. (24051375)
2013
7
Tendon structure and extracellular matrix components are affected by spasticity in cerebral palsy patients. (23885344)
2013
8
Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). (23165507)
2013
9
Sensory feedback to ankle plantar flexors is not exaggerated during gait in spastic children with cerebral palsy. (24225545)
2013
10
Revisiting physiologic and psychologic triggers that increase spasticity. (23620900)
2013
11
Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3. (23975261)
2013
12
Poststroke spasticity: Treating to the disability. (23437441)
2013
13
Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up. (23869330)
2013
14
Identification of a novel homozygous SPG7 mutation in a Japanese patient with spastic ataxia: making an efficient diagnosis using exome sequencing for autosomal recessive cerebellar ataxia and spastic paraplegia. (23857099)
2013
15
Hip flexion deformity improves without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia. (22878968)
2012
16
The relationship between spasticity and muscle volume of the knee extensors in children with cerebral palsy. (22466388)
2012
17
Visual impairment in children with spastic cerebral palsy measured by psychophysical and electrophysiological grating acuity tests. (23030659)
2012
18
Botulinum toxin type A in the healing of chronic lesion following bilateral spasticity of gluteus muscle. (23078619)
2012
19
Outcomes of correction of internal hip rotation in patients with spastic cerebral palsy using proximal femoral osteotomy. (22425638)
2012
20
Cerebellar cognitive affective syndrome and autosomal recessive spastic ataxia of charlevoix-saguenay: a report of two male sibs. (22441213)
2012
21
Commentary on an article by Pamela Thomason, BPhty, MPT, et al.: "Single-event multilevel surgery in children with spastic diplegia. A pilot randomized controlled trial". (21368072)
2011
22
Bladder dysfunction in hereditary spastic paraplegia: what to expect? (19726407)
2010
23
Upper limb spasticity reduction following active training: a robot-mediated study in patients with chronic hemiparesis. (20411224)
2010
24
Botulinum toxin to treat upper-limb spasticity in hemiparetic patients: analysis of function and kinematics of reaching movements. (20067949)
2010
25
Long-term treatment of spasticity with botulinum toxin type A: an analysis of 1221 treatments in 137 patients. (19726016)
2010
26
Hereditary spastic paraplegia and amyotrophy associated with a novel locus on chromosome 19. (20039086)
2010
27
Surgical management of spasticity in persons with cerebral palsy. (19769917)
2009
28
New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP). (19034539)
2009
29
Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia. (19917823)
2009
30
Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis. (18949264)
2008
31
Eight novel mutations in SPG4 in a large sample of patients with hereditary spastic paraplegia. (16682546)
2006
32
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in SALo Paulo, Brazil. (16862321)
2006
33
Primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis: discrete entities or spectrum? (16036421)
2005
34
A novel NIPA1 mutation associated with a pure form of autosomal dominant hereditary spastic paraplegia. (15711826)
2005
35
A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. (15534188)
2004
36
Gait analysis of sporadic and hereditary spastic paraplegia. (15164190)
2004
37
Private SACS mutations in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) families from Turkey. (15156359)
2004
38
The characteristics of sit-to-stand transfer in young children with spastic cerebral palsy based on kinematic and kinetic data. (12535725)
2003
39
Three novel spastin (SPG4) mutations in families with autosomal dominant hereditary spastic paraplegia. (12163196)
2002
40
Tropical spastic paraparesis: an old disease with a new name. (11176945)
2001
41
Motor evoked potentials from the external anal sphincter in patients with autosomal dominant pure spastic paraplegia linked to chromosome 2p. (11561054)
2001
42
Early mobilization after sliding achilles tendon lengthening in children with spastic cerebral palsy. (11139029)
2000
43
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
44
Stance balance control with orthoses in a group of children with spastic cerebral palsy. (10576639)
1999
45
Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q. (9973294)
1999
46
Spastic paraparesis in alcoholic cirrhosis with portal systemic encephalopathy. (11273332)
1998
47
A male child with the rumpshaker mutation, X-linked spastic paraplegia/Pelizaeus-Merzbacher disease and lysinuria. (9427151)
1997
48
Autosomal dominant familial spastic paraplegia: reduction of the FSP1 candidate region on chromosome 14q to 7 cM and locus heterogeneity. (7825576)
1995
49
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom. (2775992)
1989
50
Spastic entropion correction; Wheeler's orbicularis advancement. (18114398)
1949

Variations for Spasticity

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Expression for genes affiliated with Spasticity

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Expression patterns in normal tissues for genes affiliated with Spasticity

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Pathways for genes affiliated with Spasticity

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Compounds for genes affiliated with Spasticity

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GO Terms for genes affiliated with Spasticity

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Biological processes related to Spasticity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082198.9KIAA0196, SACS, C19orf12, GBA2

Products for genes affiliated with Spasticity

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  • Antibodies
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  • Lysates

Sources for Spasticity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet