Spasticity malady

NINDS: Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness of muscle, which might ³¹

MalaCards: Spasticity is related to spastic paraplegia and paraplegia. An important gene associated with Spasticity is KIAA0196 (KIAA0196), and among its related pathways are Immune System and Antigen processing and presentation. The compounds thymidine and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and spinal cord, and related mouse phenotypes are behavior/neurological and reproductive system.

Wikipedia: Spasticity is a feature of altered skeletal muscle performance in muscle tone involving hypertonia; it...⁴⁴ more...

spasticity 31

Diseases related to spasticity by text searches and GeneDecks gene sharing:

(show top 50)    (show all 716)

id	Related Disease	Score	Top Affiliating Genes
1	spastic paraplegia	51.6	PI4K2A, REEP1, WASH1, KIF1A, KIAA0196, KIF5A
2	paraplegia	51.5	PI4K2A, REEP1, WASH1, KIF1A, KIAA0196, KIF5A
3	spastic paraparesis	44.0	PDCD1, CNTN2, KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3
4	hereditary spastic paraplegia	39.8	KIF5A, ATL1, KATNB1, ALS2, HSPD1, SPAST
5	tropical spastic paraparesis	36.5	CNTN2, ITGAL, ITGB2, MMP9, FOXP3, IRF4
6	ataxia	36.0	ZNF592, SGCG, BTD, MYC, BAMBI, MT-ATP6
7	spastic ataxia	35.6	ZNF592, SGCG, MTPAP, SACS, SAX1, SAX2
8	corpus callosum	35.0	BSCL2, RAB3GAP1, RAB3GAP2, RAB18, ZFYVE26, L1CAM
9	htlv-1 associated myelopathy	34.5	PDCD1, CNTN2, VDR, MYC, JUN, CD274
10	htlv-1 associated myelopathy/tropical spastic paraparesis	34.3	PDCD1, VDR, MYC, JUN, CD274, IL2
11	spastic quadriplegia	34.2	SDHA, SDHAF1, KANK1, FUCA1, FUCA2, MOCS2
12	spastic paraplegia 3a	34.2	ATL1, SPAST, NIPA1, DNAH8
13	spastic diplegia	33.8	RAB3GAP1, RAB3GAP2, RAB18, L1CAM, MSD, ATRX
14	neuropathy	33.7	SGCG, CNR1, KIF1A, KIF5A, BTD, BSCL2
15	pelizaeus-merzbacher disease	33.7	MPZ, MBP, GPM6A, GPM6B, GJC2, AIMP1
16	spastic paraplegia 17	33.7	BSCL2, ATL1, ARL2, CAPN1, SPG38, SPAST
17	neuronitis	33.2	PI4K2A, CNR1, CNTN2, KIF1A, KIR2DS4, KIF5A
18	spastic hemiplegia	32.4	COL4A2, C1QTNF5, HFM1, TSPAN7, SOLH, LY96
19	axonal neuropathy	32.3	KIF1A, KIF5A, ZFYVE26, SACS, ATL1, MPZ
20	spastic cerebral palsy	31.9	NETO2, SIRPA, GAD1, GAD2
21	paralysis	31.8	T, MPZ, CD274, ARHGEF2, INS, IL10
22	alzheimer's disease	31.6	PI4K2A, CNR1, VEGFA, VDR, MYC, RAC1
23	spastic paraplegia 3	31.6	ATL2, ATL1, ATL3, SPG3B
24	t-cell leukemia	31.3	CNTN2, MYC, JUN, CD4, CDKN3, ITGAL
25	leukemia	31.3	PDCD1, CNR1, CNTN2, KIR2DS3, KIR2DS5, KIR3DL2
26	intellectual disability	31.2	KIF1A, RAB3GAP1, KDM5C, L1CAM, ATRX, ARHGEF6
27	hydrocephalus	30.8	MTHFR, L1CAM, IQCB1, ARSA, INS, IL10
28	cerebritis	30.5	CNR1, CNTN2, BTD, SEPSECS, VEGFA, MYC
29	multiple sclerosis	30.5	CD24, IL2RA, IL7R, MBP, IFNG, HLA-A
30	dementia	30.3	VEGFA, PANK2, BCR, MTHFR, MT-ATP6, MT-ND1
31	cerebral palsy	30.0	GCH1, MYH1, MTHFR, ATL1, KANK1, IQCB1
32	quadriplegia	29.9	SDHA, SDHAF1, KANK1, ARG1, AP4M1, ALDH3A2
33	lateral sclerosis	29.8	ARHGEF2, MAPT, ALS2, SPAST, SOD1
34	leukemia/lymphoma	29.8	PDCD1, CNTN2, VEGFA, MYC, BCR, MTHFR
35	human t-cell leukemia virus type 1	29.5	PDCD1, CNTN2, MYC, RAB3GAP1, JUN, CD274
36	cerebellar ataxia	29.3	ZNF592, MTPAP, SACS, ATXN3, FOLR1, ARHGEF2
37	choreoathetosis	29.1	HSD17B10, HPRT1, NUP62, CSE, SLC2A1
38	adult t-cell leukemia	28.9	KIR2DL1, KIR2DL3, MYC, BCR, CD8A, CD4
39	motor neuron disease	28.7	BTD, BSCL2, VEGFA, ATL1, CDK5, ARHGEF2
40	paine syndrome	28.7	GCH1, MSD, CDKN3, IL10, IL2, CCL3
41	polymyositis	28.7	CNTN2, VEGFA, JUN, CD8A, CD274, ITGB2
42	microcephaly	28.6	ZNF592, CNTN2, SEPSECS, RAB3GAP1, RAB3GAP2, RAB18
43	temporal lobe epilepsy	28.1	CNR1, BAMBI, MMP9, CCL3, GJA1, SPAST
44	leukodystrophy	28.0	SDHA, MT-ND6, MPZ, FOLR1, MLC1, ARSA
45	optic atrophy	28.0	ZNF592, KIAA0196, BTD, RAB3GAP1, RAB3GAP2, RAB18
46	hepatitis b	28.0	PDCD1, CD274, IL10, IL2RA, IFNG, HLA-DQB1
47	connective tissue disease	27.9	SERPINH1, B2M, CD4, FOXP3, INS, IL10
48	short stature	27.9	ZNF592, VDR, KDM5C, ATRX, MMP9, INS
49	amyotrophic lateral sclerosis	27.9	CNR1, VEGFA, VDR, RAC1, PANK2, MTHFR
50	hepatitis	27.8	SEPSECS, ARG1, IL2RB, FASLG, IFNB1, HLA-A

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spasticity:

²²

MGI Mouse Phenotypes related to spasticity:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	12.1	PI4K2A, SGCG, CNR1, CNTN2, KIF1A, KIF5A
2	reproductive system phenotype	MP:0005389	11.9	PI4K2A, VEGFA, VDR, PANK2, B2M, L1CAM
3	nervous system phenotype	MP:0003631	11.5	PI4K2A, PDCD1, CNR1, CNTN2, SERPINH1, VAV2
4	normal phenotype	MP:0002873	11.4	PI4K2A, VEGFA, VAV3, MYC, MYO9B, KDM5C
5	growth/size phenotype	MP:0005378	11.3	PI4K2A, SGCG, CNR1, KIF1A, KIF5A, BTD
6	integument phenotype	MP:0010771	11.3	CNR1, KIF1A, BTD, BTK, BSCL2, MYC
7	mortality/aging	MP:0010768	11.3	PI4K2A, PDCD1, SGCD, SGCG, CNR1, KIF1A
8	hematopoietic system phenotype	MP:0005397	10.8	PDCD1, BTK, BSCL2, VAV2, VAV3, MYO9B
9	no phenotypic analysis	MP:0003012	10.6	CNR1, BSCL2, VEGFA, MYC, RAB18, MTHFR
10	skeleton phenotype	MP:0005390	10.6	SGCG, CNR1, VEGFA, VDR, MYC, MYH1
11	vision/eye phenotype	MP:0005391	10.5	PDCD1, BTD, VEGFA, VAV2, VAV3, PANK2
12	immune system phenotype	MP:0005387	10.4	BTK, BSCL2, VDR, VAV2, VAV3, MYO9B
13	cellular phenotype	MP:0005384	10.2	PDCD1, SGCG, CNR1, KIF5A, BTK, BSCL2
14	homeostasis/metabolism phenotype	MP:0005376	10.0	PI4K2A, SGCD, SGCG, CNR1, KIF5A, BTD
15	liver/biliary system phenotype	MP:0005370	9.9	BSCL2, VEGFA, ARHGAP1, INS, IL12RB2, IL2
16	digestive/alimentary phenotype	MP:0005381	9.7	BTK, BSCL2, VEGFA, VDR, VAV2, VAV3
17	muscle phenotype	MP:0005369	9.5	PDCD1, SGCD, SGCG, BTD, VEGFA, VAV2
18	cardiovascular system phenotype	MP:0005385	9.3	PDCD1, SGCD, SGCG, BSCL2, VEGFA, VDR

Articles related to spasticity:

(show top 50)    (show all 423)

id	Title	Authors	Year	Affiliating Genes
1	Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARS ACS). (21507954)	Kozlov G.... Gehring K.	2011	SACS
2	Programmed death-1 (PD-1)/PD-1 ligand pathway-mediate d immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1 -associated myelopathy/tropical spastic paraparesis and carriers with autoimmun e disorders. (21851845)	Kozako T.... Arima N.	2011	PDCD1, CD274
3	Hereditary spastic paraplegia-like disorder due to a mitochondrial ATP6 gene point mutation. (20656066)	Verny C.... Procaccio V.	2011	MT-ATP6
4	Mutation analysis of the SPG4 gene in Italian patient s with pure and complicated forms of spastic paraplegia. (19875132)	Magariello A.... Quattrone A.	2010	SPAST
5	Absence of consistent association between human leuko cyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-a ssociated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro -Caribbean population. (20851016)	Deschamps R.... Olindo S.	2010	HLA-A, HLA-DQB1, HLA-DRB1
6	SPG11 spastic paraplegia. A new cause of juvenile par kinsonism. (19224311)	Anheim M.... Tranchant C.	2009	SPG11
7	Posterior fossa abnormalities in hereditary spastic paraparesis with spastin mutations. (19289482)	Scuderi C.... Musumeci S.A.	2009	SPAST
8	Frequency and phenotype of SPG11 and SPG15 in complic ated hereditary spastic paraplegia. (19917823)	SchA1le R.... Bauer P.	2009	ZFYVE26, SPG11
9	Novel GFAP mutation in patient with adult-onset Alexa nder disease presenting with spastic ataxia. (19412928)	Kaneko H.... Ikeuchi T.	2009	GFAP
10	Dementia in SPG4 hereditary spastic paraplegia: clini cal, genetic, and neuropathologic evidence. (19652142)	Murphy S.... Hutchinson M.	2009	SPAST
11	Clinical and genetic study of SPG6 mutation in a Chinese family with hereditary spastic paraplegia. (17928003)	Liu S.G.... Ma X.	2008	NIPA1
12	Hereditary spastic paraplegia, bipolar affective disorder and intellectual disability: a case report. (18337300)	Whitty M.... Ramsay L.	2008	SPAST
13	A clinical, genetic, and biochemical characterization of SPG7 mutations in a large cohort of patients with hereditary spastic paraplegia. (18200586)	Arnoldi A.... Bassi M.T.	2008	SPG7
14	Hereditary spastic paraplegia caused by the novel mutation 1047insC in the SPG7 gene. (18563470)	Tzoulis C.... Bindoff L.A.	2008	SPG7
15	SPG11 compound mutations in spastic paraparesis with thin corpus callosum. (18663179)	Samaranch L.... Pastor P.	2008	SPG11
16	Analysis and mapping of CACNB4, CHRNA1, KCNJ3, SCN2A and SPG4, physiological candidate genes for porcine congenital progressive ataxia and spastic paresis. (17868079)	Genini S.... Vogeli P.	2007	SPAST
17	No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis. (17632280)	Karlstrom H.... Schofield P.R.	2007	PSEN1
18	A new locus for autosomal recessive spastic paraplegia (SPG32) on chromosome 14q12-q21. (17515546)	Stevanin G.... Hazan J.	2007	SPG32
19	Infantile onset of hereditary spastic paraplegia poorly predicts the genotype. (17560499)	Blair M.A.... Hedera P.	2007	SPAST
20	Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia. (18067136)	Hehr U.... Winkler J.	2007	SPG11
21	Translating m-AAA protease function in mitochondria to hereditary spastic paraplegia. (16647881)	Rugarli E.I.... Langer T.	2006	SPG7
22	Clinical and genetic study of a Brazilian family with spastic paraplegia (SPG6 locus). (16267846)	Munhoz R.P.... Rogaeva E.	2006	NIPA1
23	Spastin gene mutations in Bulgarian patients with hereditary spastic paraplegia. (17100993)	Ivanova N.... Mitev V.	2006	SPAST
24	High frequency of partial SPAST deletions in autosomal dominant hereditary spastic paraplegia. (17035675)	Beetz C.... Deufel T.	2006	SPAST
25	Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: application of best-fit logistic regression equation based on host genotype, age, and provirus load. (16877298)	Nose H.... Osame M.	2006	CXCL12
26	Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia. (16357941)	Pirozzi M.... Rugarli E.I.	2006	SPG7
27	Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. (15652420)	Fukushima N.... Eguchi K.	2005	IFNG
28	Spastic paraplegia, optic atrophy, and neuropathy is linked to chromosome 11q13. (15852396)	Macedo-Souza L.I.... Zatz M.	2005	ZFP90, SPOAN
29	Novel mutation of SACS gene in a Spanish family with autosomal recessive spastic ataxia. (16007637)	Criscuolo C.... Berciano J.	2005	SACS
30	A novel NIPA1 mutation associated with a pure form of autosomal dominant hereditary spastic paraplegia. (15711826)	Reed J.A.... Warner T.T.	2005	NIPA1
31	A case of complicated spastic paraplegia 2 due to a point mutation in the proteolipid protein 1 gene. (15450775)	Lee E.S.... Hobson G.M.	2004	PLP1
32	Novel insertional presenilin 1 mutation causing Alzheimer disease with spastic paraparesis. (15159497)	Moretti P.... Foster N.L.	2004	PSEN1
33	Hereditary spastic paraplegia: clinical genetic study of 15 families. (15210521)	Orlacchio A.... Bernardi G.	2004	SPAST
34	Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin gene. (12876245)	Bonsch D.... Liepert J.	2003	SPAST
35	Pelizaeus-Merzbacher disease and spastic paraplegia type 2: two faces of myelin loss from mutations in the same gene. (14572140)	Hudson L.D.	2003	PLP1
36	The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. (12676568)	Ciccarelli F.D.... Crosby A.H.	2003	SPAST, SPG20, SNX15
37	Familial spastic paraplegia as the presenting manifestation in patients with purine nucleoside phosphorylase deficiency. (12693783)	Tabarki B.... Essoussi A.S.	2003	PNP
38	A locus for autosomal dominant hereditary spastic ataxia, SAX1, maps to chromosome 12p13. (11774073)	Meijer I.A.... Rouleau G.A.	2002	SAX1
39	Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution. (12571785)	Ramaekers V.T.... Blau N.	2002	FOLR1
40	X-linked myoclonic epilepsy with spasticity and intellectual disability: mutation in the homeobox gene ARX. (12177367)	Scheffer I.E.... Mulley J.C.	2002	ARX
41	Mutation analysis of the spastin gene (SPG4) in patients in Germany with autosomal dominant hereditary spastic paraplegia. (12124993)	Sauter S.M.... Neesen J.	2002	SPAST
42	Missense and splice site mutations in SPG4 suggest loss-of-function in dominant spastic paraplegia. (11985387)	Patrono C.... Santorelli F.M.	2002	SPAST
43	Genetic mapping of a susceptibility locus for disc herniation and spastic paraplegia on 6q23.3-q24.1. (12070243)	Zortea M.... Mostacciuolo M.L.	2002	SPG25
44	High frequencies of Th1-type CD4(+) T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1-associated myelopathy/tr opical spastic paraparesis. (11964301)	Goon P.K.... Bangham C.R.	2002	CNTN2
45	ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF. (10655055)	Engert J.C.... Richter A.	2000	SACS
46	Increased activity of metalloproteinases and their inhibitors in cerebrospinal fluid of patients with tropical spastic paraparesis (11016056)	Valenzuela M.A.... Cartier L.	2000	MMP9
47	Hydrocephalus and spastic paraplegia result from a donor splice site mutation (2872 + 1G to A) in the L1CAM gene in a Venezuelan pedigree. (9452098)	Claes S.... Raeymaekers P.	1998	L1CAM
48	Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis. (8733061)	Elmslie F.V.... Rees M.	1996	GLRA1
49	CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. (8556302)	Fransen E.... Willems P.J.	1995	L1CAM
50	Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity. (7987300)	Hentati A.... Siddique T.	1994	CYP7B1

Genes related to spasticity according to GeneCards:

(show top 50)    (show all 339)

id	Symbol	Description	Score	GeneCards Section Context
1	KIAA0196	KIAA0196	11.1	Aliases & Descriptions, Publications, Summaries
2	SPAST	spastin	11.1	Orthologs, Aliases & Descriptions, Publications, Summaries
3	ATL1	atlastin GTPase 1	11.1	Aliases & Descriptions, Summaries, Publications
4	SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	11.1	Orthologs, Transcripts, Publications, Aliases & Descriptions (show all 5 sections) Summaries
5	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1	11.1	Publications, Aliases & Descriptions, Summaries
6	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	11.1	Aliases & Descriptions, Publications, Transcripts, Orthologs (show all 5 sections) Summaries
7	SPG11	spastic paraplegia 11 (autosomal recessive)	11.1	Summaries, Aliases & Descriptions, Orthologs, Publications
8	PLP1	proteolipid protein 1	11.1	Aliases & Descriptions, Publications, Orthologs, Summaries
9	FA2H	fatty acid 2-hydroxylase	11.1	Publications, Summaries, Aliases & Descriptions
10	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.1	Publications, Aliases & Descriptions, Summaries
11	SPG20	spastic paraplegia 20 (Troyer syndrome)	11.1	Summaries, Aliases & Descriptions, Orthologs, Publications (show all 5 sections) Transcripts
12	KIF5A	kinesin family member 5A	11.1	Summaries, Aliases & Descriptions, Publications
13	SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	11.1	Summaries, Aliases & Descriptions, Publications
14	ZFYVE26	zinc finger, FYVE domain containing 26	11.1	Summaries, Aliases & Descriptions, Publications
15	KIF1A	kinesin family member 1A	11.1	Summaries, Publications, Aliases & Descriptions
16	AP4B1	adaptor-related protein complex 4, beta 1 subunit	11.1	Aliases & Descriptions, Summaries, Publications
17	ALS2	amyotrophic lateral sclerosis 2 (juvenile)	11.1	Summaries, Publications
18	AFG3L2	AFG3 ATPase family gene 3-like 2 (S. cerevisiae)	11.1	Orthologs, Publications, Summaries
19	L1CAM	L1 cell adhesion molecule	11.1	Publications, Summaries
20	ZFYVE27	zinc finger, FYVE domain containing 27	11.0	Publications, Summaries
21	REEP1	receptor accessory protein 1	11.0	Publications, Summaries
22	SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	11.0	Aliases & Descriptions, Publications, Transcripts, Orthologs
23	CSE	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	11.0	Publications, Aliases & Descriptions
24	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	11.0	Publications, Aliases & Descriptions
25	ERLIN2	ER lipid raft associated 2	11.0	Publications, Summaries
26	PNPLA6	patatin-like phospholipase domain containing 6	11.0	Summaries
27	KANK1	KN motif and ankyrin repeat domains 1	11.0	Summaries
28	SPG19	spastic paraplegia 19 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
29	SPG29	spastic paraplegia 29 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
30	SPG9	spastic paraplegia 9 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
31	SPG14	spastic paraplegia 14 (autosomal recessive)	11.0	Aliases & Descriptions, Publications
32	SPG16	spastic paraplegia 16 (complicated, X-linked recessive)	11.0	Publications, Aliases & Descriptions
33	CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	11.0	Publications, Aliases & Descriptions
34	SPG18	spastic paraplegia 18 (autosomal dominant)	11.0	Aliases & Descriptions
35	SPG24	spastic paraplegia 24 (autosomal recessive)	11.0	Publications, Aliases & Descriptions
36	SPG25	spastic paraplegia 25 (autosomal recessive, with disc herniation)	11.0	Aliases & Descriptions, Publications
37	SAX1	spastic ataxia 1 (autosomal dominant)	11.0	Publications, Aliases & Descriptions
38	SPOAN	spastic paraplegia, optic atrophy, and neuropathy	11.0	Aliases & Descriptions, Publications
39	SPG23	spastic paraplegia 23 (autosomal recessive)	11.0	Publications, Aliases & Descriptions
40	SPG27	spastic paraplegia 27 (autosomal recessive)	11.0	Aliases & Descriptions, Publications
41	SPG26	spastic paraplegia 26	11.0	Aliases & Descriptions, Publications
42	SPG37	spastic paraplegia 37 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
43	SPG38	spastic paraplegia 38 (autosomal dominant, Silver syndrome)	11.0	Aliases & Descriptions, Publications
44	SPG34	spastic paraplegia 34 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
45	SAX2	spastic ataxia 2 (autosomal recessive)	11.0	Aliases & Descriptions, Publications
46	SPG41	spastic paraplegia 41 (autosomal dominant)	11.0	Aliases & Descriptions, Publications
47	AP4S1	adaptor-related protein complex 4, sigma 1 subunit	11.0	Summaries, Publications
48	RTN2	reticulon 2	11.0	Publications, Summaries, Aliases & Descriptions
49	SPG5B	spastic paraplegia 5B (autosomal recessive)	11.0	Aliases & Descriptions
50	SPAX3	Ataxia, spastic, 3, autosomal recessive	11.0	Aliases & Descriptions

Pathways related to spasticity according to GeneDecks:

(show top 50)    (show all 97)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	12.1	KIR2DL3, KIR2DS5, KIF5A, KIR3DS1, PDCD1, KIR2DL2
2	Antigen processing and presentation20	12.0	KIR2DS3, HLA-C, HLA-DRB1, KIR3DL1, KIR2DS4, KIR2DL4
3	Cytokine-cytokine receptor interaction20	11.8	CXCL1, TNFSF8, VEGFA, IFNG, IFNB1, FASLG
4	STAT3 Pathway36	11.7	MAP2K4, CD4, CCL3, TNFSF8, CXCL1, CXCL12
5	Graft-versus-host disease20	11.7	FASLG, HLA-A, KIR3DL2, KIR2DL1, KIR3DL1, KIR2DL5A
6	Immune response IL-22 signaling pathway10	11.6	HLA-DQB1, HLA-DRB1, MAPK8, IL2RB, IL2RA, IL12RB2
7	Immune response_IL-22 signaling pathway41	11.6	IL2RA, MYC, JUN, CD4, HLA-DQB1, IL12RB2
8	Natural killer cell mediated cytotoxicity20	11.5	KIR2DS5, VAV3, RAC1, KIR3DL2, ITGAL, ITGB2
9	Allograft rejection20	11.4	HLA-A, IFNG, FASLG, HLA-DRB1, HLA-DQB1, HLA-C
10	Rheumatoid arthritis20	11.4	ACP5, HLA-DQB1, IFNG, IL15, CCL3, CXCL12
11	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	11.3	IL15, IL2, IL2RA, IL2RB, FASLG, CCL3
12	THC Differentiation Pathway36	11.3	IL12RB1, IL2, IL10, IL12RB2, HLA-DQB1, IL2RA
13	Antioxidant Action of Vitamin-C36	11.3	SLC2A1, CXCL12, CXCL1, CX3CR1, PLA2G2A, TNFSF8
14	Type I diabetes mellitus20	11.3	INS, HLA-B, HLA-DRB1, GAD2, GAD1, IL2
15	Immune response Role of DAP12 receptors in NK cells10	11.2	KIR2DS2, VAV3, HLA-C, HLA-B, VAV2, KIR2DL2
16	Cell adhesion molecules (CAMs)20	11.2	JAM3, CNTN2, L1CAM, MPZ, CD8A, CD4
17	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	11.1	IL2RA, IL2RB, FOXP3, IL10, IL2, FASLG
18	Jak-STAT signaling pathway20	11.1	IL12RB2, IL12RB1, MYC, IL10, IL2RB, SOS1
19	MAPK Family Pathway36	11.1	MCF2L, IL7R, ARHGEF9, IL2RB, ARHGEF1, ARHGEF15
20	Molecular Mechanisms of Cancer36	10.9	IL7R, IL2, IL15, MCF2L, IL12RB2, ARHGEF3
21	MIF Regulation of Innate Immune Cells36	10.9	LY96, PLA2G2A, TNFSF8, CCL3, MAPK8, IL2
22	Neuroscience3	10.9	SLC1A2, GAD2, GAD1, HTT, MAPT, MECP2
23	Immune response_Role of DAP12 receptors in NK cells41	10.8	KIR2DL1, HLA-B, KIR2DL3, KIR2DL4, HLA-C, RAC1
24	Viral myocarditis20	10.7	HLA-DQB1, HLA-DRB1, HLA-C, HLA-B, HLA-A, ITGB2
25	T cell receptor signaling pathway20	10.7	IL10, PDCD1, VAV3, CD8A, CD4, IL2
26	Recycling of eIF2:GDP38	10.7	EIF2B2, EIF2B5, EIF2B3, EIF2B1, EIF2B4
27	PKC-Theta Pathway36	10.6	VAV2, MAP2K4, CD4, CD8A, JUN, RAC1
28	Signaling by Slit36	10.6	ARHGEF6, ARHGEF12, ARHGEF2, ARHGEF9, ARHGEF1, ARHGEF16
29	Ras Pathway36	10.5	MCF2L, MAP2K4, CXCL12, SOS2, SOS1, ARHGEF2
30	Rho Family GTPases36	10.5	COL4A2, GFAP, CXCL1, CXCL12, IL10, TNFSF8
31	NgR-p75(NTR)-Mediated Signaling36	10.5	MCF2L, ARHGEF9, ARHGEF2, ARHGEF16, ARHGEF12, ARHGEF6
32	CXCR4 Pathway36	10.4	RAC1, JUN, ARHGEF15, ARHGEF3, MCF2L, MAPK8
33	RhoGDI Pathway36	10.4	MAPK8, MYH1, MYO9B, CHN2, JUN, ARHGEF12
34	Cytoskeletal Signaling3	10.3	VAV3, ARHGEF1, ARHGEF2, ARHGEF6, CHN2, ZFYVE26
35	Guidance Cues and Growth Cone Motility36	10.3	ARHGEF2, RAC1, CDK5, ARHGEF6, ARHGEF12, ARHGEF15
36	G-AlphaI Signaling36	10.2	ARHGEF15, ARHGEF3, MCF2L, ARHGEF12, ARHGEF6, SOS2
37	Interferon Pathway36	10.2	VAV2, VAV3, RAC1, ARHGEF6, ARHGEF2, ARHGEF16
38	Internalin Pathway36	10.2	SOS2, SOS1, ARHGEF3, ARHGEF1, ARHGEF9, RAC1
39	Signalling by NGF38	10.2	ARHGEF2, PREX1, TIAM1, NGEF, PLEKHG2, AKAP13
40	RhoA Pathway36	10.2	ARHGAP1, ARHGEF12, ARHGEF16, ARHGEF9, ARHGEF1, ARHGEF15
41	G-protein signaling RhoA regulation pathway10	10.1	ARHGAP1, ARHGEF1, ARHGEF3, MCF2L, NGEF, RHOA
42	G-protein signaling_RhoA regulation pathway41	10.1	RAC1, ARHGEF12, ARHGEF2, ARHGAP1, ARHGEF1, ARHGEF3
43	G-AlphaQ Signaling36	10.1	ARHGEF16, ARHGEF2, ARHGEF9, ARHGEF15, ARHGEF3, MCF2L
44	Neurophysiological process Receptor-mediated axon growth repulsion10	10.0	RAC1, ARHGEF12, MAPT, RHOA, NGEF, VAV2
45	G-protein signaling Regulation of RAC1 activity10	10.0	TIAM1, ARHGAP1, ARHGEF2, ARHGAP9, CHN2, BCR
46	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins10	9.9	RHOA, MAPK8, VAV2, RAC1, ARHGEF12, ARHGEF1
47	G-protein signaling_G-Protein alpha-12 signaling pathway41	9.8	RASA2, ARHGEF12, BTK, ARHGEF1, MAPK8, RAC1
48	G-protein signaling G-Protein alpha-12 signaling pathway10	9.7	RHOA, AKAP13, MAP2K4, MAPK8, ARHGEF1, ARHGEF12
49	Phospholipase-C Pathway36	9.6	ARHGEF12, COL4A2, CXCL12, SOS2, ARHGEF6, ITGB2
50	Neurophysiological process_Receptor-mediated axon growth repulsion41	9.3	TUBB3, MAPT, NGEF, RHOA, TIAM1, TUBA1A

Compounds related to spasticity according to GeneDecks:

(show top 50)    (show all 179)

id	Compound	Score	Top Affiliating Genes
1	thymidine32 18	13.1	CNTN2, VDR, MYC, RAC1, BCR, MTHFR
2	cyclosporin a32 42	13.1	CNTN2, SERPINH1, SEPSECS, VDR, MYC, MTHFR
3	aspartate32	11.9	CNR1, VDR, B2M, MPZ, ITGB2, MMP9
4	rantes32	11.9	RAC1, JUN, CD4, ITGAL, ITGB2, MMP9
5	dexamethasone32 42 34 9 9	15.7	VEGFA, VDR, MYC, JUN, CD274, ITGAL
6	arsenite32 18	12.6	CNTN2, VEGFA, VDR, MYC, RAC1, JUN
7	oligonucleotide32	11.5	CNTN2, KIR3DL1, BTK, SERPINH1, MYC, RAC1
8	cisplatin32 34 9 9	14.5	VEGFA, MYC, RAC1, MTHFR, B2M, CDKN3
9	adenylate32	11.5	CNR1, VDR, CDKN3, CDK1, ITGB2, MMP9
10	cycloheximide32	11.5	CNTN2, VEGFA, VDR, MYC, RAC1, B2M
11	retinoic acid32 42 18	13.5	CNTN2, KIR2DS4, VDR, MYC, RAC1, MTHFR
12	ionomycin32	11.3	CNTN2, BTK, CD274, IL12RB1, IL7R, CCL3
13	n acetylcysteine32	11.2	CDK5, CDK1, MMP9, IL2RA, IL2RB, MBP
14	cysteine32	11.2	CNTN2, KIR2DS4, BTD, BTK, VDR, RAC1
15	thymidylate32	11.2	VEGFA, VDR, MTHFR, B2M, CDK1, FOLR1
16	glutamate32	11.2	PI4K2A, CNR1, CNTN2, VDR, MTHFR, L1CAM
17	lactacystin32	11.1	VDR, MYC, JUN, CD4, CDKN3, CDK1
18	tacrolimus32 34 9 9	14.1	VDR, MYC, CDKN3, ITGAL, INS, IL10
19	h2o232	11.1	CNTN2, GCH1, BCR, CDK5, CDKN3, ITGAL
20	oxygen32 18	12.1	CNTN2, GCH1, RAC1, BCR, SDHA, MT-ATP6
21	glatiramer acetate32 9 9	13.0	MPZ, IL10, IL2, MBP, IFNB1, IFNG
22	actinomycin d32	11.0	VEGFA, VDR, MYC, JUN, CDKN3, ITGAL
23	tyrosine32	11.0	PDCD1, CNTN2, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1
24	superoxide32 18	11.9	GCH1, RAC1, CDK5, ITGAL, ITGB2, IL15
25	guanine32 9 18 9	13.9	CNR1, CNTN2, GCH1, VDR, RASA2, RAC1
26	ly29400232	10.9	VEGFA, BCR, JUN, CDKN3, CDK1, ITGB2
27	cyclophosphamide32 34 9 9	13.9	ITGAL, ITGB2
28	indomethacin32 9 9	12.9	CNR1, MYC, B2M, CDKN3, ITGB2, IL2
29	proline32	10.7	BTK, SERPINH1, RAC1, MT-ATP6, MT-ND1, CDK5
30	creatinine32	10.7	VDR, MTHFR, B2M, MPZ, ITGB2, MMP9
31	4-hydroxynonenal32 18	11.7	MYC, JUN, IL10, ANXA5, MAPT, MAPK8
32	genistein32 9 18 9	13.7	BTK, VEGFA, VDR, MYC, RAC1, BCR
33	rapamycin32 42	11.7	VEGFA, CDK5, CDK1, FOXP3, INS, IL2
34	herbimycin a32 42	11.7	MYC, JUN, CD4, CDKN3, ITGB2, MMP9
35	pge232	10.6	RAC1, CD4, FOXP3, ARG1, FASLG, CCL3
36	arginine32	10.5	CNR1, CNTN2, KIR2DL4, GCH1, BTD, BTK
37	paclitaxel32 34 9 9	13.5	VEGFA, MYC, RAC1, CDK5, CDK1, ITGB2
38	azathioprine32 34 9 9	13.4	RAC1, MTHFR, ITGAL, MECP2, IL10, IL2
39	ivig32	10.4	BTK, SEPSECS, FASLG, MBP, IFNB1, CRP
40	sb 20358032 42	11.3	BTK, VEGFA, VDR, RAC1, CDK1, ITGB2
41	alanine32	10.3	CNR1, CNTN2, BTD, VDR, MYC, MT-ND1
42	vegf32	10.1	CNTN2, SERPINH1, VAV2, MYC, RAC1, CDKN3
43	methionine32	10.1	GCH1, SERPINH1, MT-ND1, MT-ND6, FUCA1, MPZ
44	phosphatidylinositol32	10.1	PI4K2A, BTK, VAV2, VAV3, MYC, RASA2
45	valine32	9.8	RAC1, MT-ND4, MTHFR, MT-ND1, MT-ND6, B2M
46	lipid32	9.8	CNR1, KIR2DL1, KIR3DL1, BTK, RASA2, RAC1
47	lactate32	9.8	BTD, MT-ND4, MT-ND1, B2M, FUCA1, CDKN3
48	gtp32	9.7	GCH1, VAV2, RAB3GAP1, RASA2, RAC1, BCR
49	serine32	9.4	CNR1, CNTN2, GCH1, BTD, BTK, SERPINH1
50	atp32	INF	KIR3DL1, BTK, SERPINH1, MYH1, MYO9B, RAC1

Cellular components related to spasticity according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	12.0	HLA-A, GJA1, GLRB, GLRA1, HTR2A, FASLG
2	external side of plasma membrane	GO:009897	11.3	ITGAL, CD274, CD4, CD8A, B2M, IL12RB1
3	plasma membrane	GO:005886	11.0	KIR2DL3, KIR2DL1, KIR3DL3, KIR3DL2, CNTN2, CNR1
4	axon	GO:030424	10.9	ALS2, TUBB3, RHOC, NEFH, HEPACAM, DST
5	ER to Golgi transport vesicle membrane	GO:012507	10.8	HLA-DQB1, B2M, HLA-A, HLA-B, HLA-DRB1, HLA-C
6	eukaryotic translation initiation factor 2B complex	GO:005851	10.5	EIF2B5, EIF2B4, EIF2B3, EIF2B2, EIF2B1
7	extracellular space	GO:005615	10.0	IL10, IL15, IL2, FASLG, CCL3, IFNB1
8	AP-type membrane coat adaptor complex	GO:030119	9.2	AP5Z1, AP5S1, AP5B1, AP4M1
9	cytosol	GO:005829	INF	MECP2, ARHGEF12, ARL2, ARHGEF6, ARHGAP9, ARHGAP10
10	cytoplasm	GO:005737	INF	AP5Z1, ARHGEF10L, ARHGEF6, IRF4, MLC1, FOXP3

Biological processes related to spasticity according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell death	GO:008219	13.0	SPAST, AFG3L2, NEFH, RTN2, SPG20, SPG7
2	immune response	GO:006955	12.4	KIR3DL1, KIR3DS1, KIR2DL3, KIR2DL1, KIR2DS5, KIR2DS2
3	regulation of immune response	GO:050776	11.7	KIR2DL1, HLA-A, HLA-B, KIR3DL1, KIR3DL2, KIR2DL3
4	cytokine-mediated signaling pathway	GO:019221	11.3	IFNB1, NUP62, RPS27A, HLA-DRB1, HLA-DQB1, HLA-C
5	interferon-gamma-mediated signaling pathway	GO:060333	11.0	IRF4, HLA-DRB1, IFNG, B2M, HLA-DQB1, HLA-C
6	response to drug	GO:042493	11.0	GAD2, GAD1, RHOC, NOS3, PNP, CYP7B1
7	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.7	HSPD1, LY96, BTK, JUN, RPS27A, MAPK8
8	cellular response to stimulus	GO:051716	10.7	EIF2B4, EIF2B5, EIF2B1, EIF2B2, EIF2B3
9	negative regulation of translational initiation in response to stress	GO:032057	10.6	EIF2B5, EIF2B4, EIF2B1, EIF2B3
10	response to heat	GO:009408	10.6	NOS3, EIF2B2, EIF2B3, EIF2B1, EIF2B4, EIF2B5
11	myelination	GO:042552	10.6	JAM3, MBP, EIF2B2, AFG3L2, EIF2B5, EIF2B4
12	positive regulation of Rho GTPase activity	GO:032321	10.5	PREX1, ARHGAP29, ARHGAP1, MYO9B, JUN, SOS1
13	response to peptide hormone stimulus	GO:043434	10.4	GJA1, NOS3, EIF2B2, EIF2B3, EIF2B1, CXCL12
14	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.4	HLA-A, HLA-C, HLA-B, B2M
15	oligodendrocyte development	GO:014003	10.3	EIF2B3, EIF2B1, EIF2B4, EIF2B5, EIF2B2
16	Rho protein signal transduction	GO:007266	10.1	ARHGEF3, MYO9B, ARHGEF1, ARHGAP29, ARHGAP1, RHOB
17	axon guidance	GO:007411	10.1	TRIO, SPTAN1, COL4A2, RHOA, RHOB, RHOC
18	blood coagulation	GO:007596	9.9	VAV3, F12, RHOA, RHOB, PSAP, SOD1
19	induction of apoptosis by extracellular signals	GO:008624	9.6	BTK, VDR, VAV2, ARHGEF6, SOS2, SOS1
20	nerve growth factor receptor signaling pathway	GO:048011	9.4	ARHGEF16, TIAM1, TRIO, VAV2, AKAP13, PLEKHG2
21	apoptotic process	GO:006915	9.4	RHOB, MAPT, MAPK8, MAP2K4, IFNG, AKAP13
22	regulation of Rho protein signal transduction	GO:035023	9.2	ARHGEF38, ARHGEF9, ARHGEF2, ARHGEF12, ARHGEF10L, ARHGEF6
23	endosomal transport	GO:016197	9.2	WASH1, RPS27A, VPS37A, AP5B1, AP5S1, AP5Z1
24	small GTPase mediated signal transduction	GO:007264	8.4	TRIO, AKAP13, MCF2L, ARHGEF3, ARHGEF17, ARHGAP29
25	regulation of small GTPase mediated signal transduction	GO:051056	8.2	MCF2L, AKAP13, TRIO, DLC1, PLEKHG2, NGEF

Molecular functions related to spasticity according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	guanyl-nucleotide exchange factor activity	GO:005085	10.3	ALS2, SOS2, EIF2B5, EIF2B4, EIF2B1, EIF2B3
2	protein binding	GO:005515	10.0	ERLIN2, F12, HTT, LONP1, CCDC53, CCL3
3	Rho GTPase activator activity	GO:005100	9.7	MYO9B, ARHGAP10, JUN, ARHGAP1, ARHGAP29, PREX1
4	GTPase activator activity	GO:005096	9.5	ARHGEF12, ARHGAP25, ARHGAP9, ARHGEF6, ARHGEF15, CHN2
5	Rho guanyl-nucleotide exchange factor activity	GO:005089	8.7	TRIO, PLEKHG2, NGEF, TIAM1, PREX1, SOS1
6	phospholipid binding	GO:005543	8.6	ARHGEF6, VAV2, ARHGEF16, VAV3, RASA2, BCR