MCID: SPC019
MIFTS: 27

Specific Language Impairment

Categories: Mental diseases, Genetic diseases

Aliases & Classifications for Specific Language Impairment

MalaCards integrated aliases for Specific Language Impairment:

Name: Specific Language Impairment 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060244

Summaries for Specific Language Impairment

Disease Ontology : 12 A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.

MalaCards based summary : Specific Language Impairment is related to specific language impairment 5 and specific language impairment 4. An important gene associated with Specific Language Impairment is FOXP2 (Forkhead Box P2). The drug Omega 3 Fatty Acid has been mentioned in the context of this disorder. Affiliated tissues include brain and testes.

Wikipedia : 72 Specific language impairment (SLI) is diagnosed when a child\'s language does not develop normally and... more...

Related Diseases for Specific Language Impairment

Graphical network of the top 20 diseases related to Specific Language Impairment:



Diseases related to Specific Language Impairment

Symptoms & Phenotypes for Specific Language Impairment

Drugs & Therapeutics for Specific Language Impairment

Drugs for Specific Language Impairment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Omega 3 Fatty Acid Nutraceutical Phase 3

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 Effectiveness of Early Parent-Based Language Intervention Unknown status NCT00625261 Phase 3
2 Feasibility of Omega-3 Supplementation for Children With Language Impairments Unknown status NCT01640106 Phase 3
3 A Comparison of Language Intervention Programs Completed NCT00033150 Phase 3
4 Deep rTMS (Repetitive Transcranial Magnetic Stimulation)for Treatment of Autism Symptoms in Children. Unknown status NCT01388179 Phase 2
5 Accelerating Word Learning in Children With Language Impairment Recruiting NCT01829360 Phase 1, Phase 2
6 Sensory and Connectivity Abnormalities in Autism and Language Disorders Unknown status NCT00956579
7 Participant Database for Autism Research Studies Unknown status NCT00549731
8 Structural Connectivity as Imaging Endophenotypes of Autism Spectrum Disorders Unknown status NCT01513629
9 Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family Unknown status NCT02055092
10 Evaluating Treatment Efficacy of Two Syntactic Treatment Procedures for Children With Specific Language Impairment (SLI): A Randomized Controlled Trial Completed NCT01765348
11 Experimental Word Learning in Children With and Without Language Impairment Completed NCT00607334
12 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
13 MR Scanning of Very Young Children With Severe Developmental Disorders Completed NCT00156221
14 Magnetoencephalographic (MEG) Evidence for Novel Metaphor Processing Among Schizophrenic Patients Completed NCT01325363
15 Characterization of Auditory Processing Involved in the Encoding of Speech Sounds Recruiting NCT02574299
16 Language and Motricity in Preterm School Age Children Recruiting NCT02811029
17 Phenotypic Specific Communication Intervention for Children With Down Syndrome Recruiting NCT02158390
18 Comparison of Interventions for Developmental Dyslexia Recruiting NCT02791841
19 Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison Recruiting NCT02753192
20 Characterisation of Primary Progressives Aphasias Recruiting NCT02297035
21 Reading Remediation and Outcomes in Detention Not yet recruiting NCT03261076

Search NIH Clinical Center for Specific Language Impairment

Genetic Tests for Specific Language Impairment

Anatomical Context for Specific Language Impairment

MalaCards organs/tissues related to Specific Language Impairment:

39
Brain, Testes

Publications for Specific Language Impairment

Articles related to Specific Language Impairment:

(show top 50) (show all 121)
id Title Authors Year
1
Distributed Training Enhances Implicit Sequence Acquisition in Children With Specific Language Impairment. ( 28854315 )
2017
2
Can you spell dyslexia without SLI? Comparing the cognitive profiles of dyslexia and specific language impairment and their roles in learning. ( 28486125 )
2017
3
Grammaticality differences between Spanish-speaking children with specific language impairment and their typically developing peers. ( 28421645 )
2017
4
Third person singular -s in typical development and specific language impairment: Input and neighbourhood density. ( 28727489 )
2017
5
Screening for Specific Language Impairment in Preschool Children: Evaluating a Screening Procedure Including the Token Test. ( 28474204 )
2017
6
The relationship between information carrying words, memory and language skills in school age children with specific language impairment. ( 28672043 )
2017
7
Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment. ( 28440294 )
2017
8
Learning and Overnight Retention in Declarative Memory in Specific Language Impairment. ( 28046095 )
2017
9
Hypertext comprehension of deaf and hard-of-hearing students and students with specific language impairment. ( 28073077 )
2017
10
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying Adequate Progress and Successful Learning Patterns. ( 28419188 )
2017
11
Statistical word learning in children with autism spectrum disorder and specific language impairment. ( 28464253 )
2017
12
The role of nonverbal working memory in morphosyntactic processing by children with specific language impairment and autism spectrum disorders. ( 28690687 )
2017
13
Sensitivity to Audiovisual Temporal Asynchrony in Children With a History of Specific Language Impairment and Their Peers With Typical Development: A Replication and Follow-Up Study. ( 28715546 )
2017
14
Case History Risk Factors for Specific Language Impairment: A Systematic Review and Meta-Analysis. ( 28672377 )
2017
15
A Preliminary Comparison of Reading Subtypes in a Clinical Sample of Children With Specific Language Impairment. ( 28820919 )
2017
16
The Role of Frequency in Learning Morphophonological Alternations: Implications for Children With Specific Language Impairment. ( 28510615 )
2017
17
The development of writing skills in 4-year-old children with and without specific language impairment. ( 28481668 )
2017
18
Procedural learning in Parkinson's disease, specific language impairment, dyslexia, schizophrenia, developmental coordination disorder, and autism spectrum disorders: A second-order meta-analysis. ( 28710941 )
2017
19
Alliteration and rhyme skills in children with specific language impairment. ( 28380200 )
2017
20
Emotional and behavioural needs in children with specific language impairment and in children with autism spectrum disorder: The importance of pragmatic language impairment. ( 28886424 )
2017
21
Using Pupillometry to Investigate Sentence Comprehension in Children With and Without Specific Language Impairment. ( 28586855 )
2017
22
Applying an Integrative Framework of Executive Function to Preschoolers With Specific Language Impairment. ( 28724132 )
2017
23
The roles of cognitive and language abilities in predicting decoding and reading comprehension: comparisons of dyslexia and specific language impairment. ( 27848086 )
2016
24
Specific Language Impairment: Evaluation and detection of differential psycholinguistic markers in phonology and morphosyntax in Spanish-speaking children. ( 27596962 )
2016
25
A Case of Specific Language Impairment in a Deaf Signer of American Sign Language. ( 27884866 )
2016
26
Executive functions and language in children with different subtypes of specific language impairment. ( 26971060 )
2016
27
Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment. ( 27378833 )
2016
28
Cross-linguistic transfer effects after phonologically based cognate therapy in a case of multilingual specific language impairment (SLI). ( 27377882 )
2016
29
Impact of specific language impairment and type of school on different language subsystems. ( 27652925 )
2016
30
Complex sentence profiles in children with Specific Language Impairment: Are they really atypical? ( 26876093 )
2016
31
Mirror-drawing skill in children with specific language impairment: Improving generalization by incorporating variability into the practice session. ( 27093974 )
2016
32
Executive Functions in Children With Specific Language Impairment: A Meta-Analysis. ( 27653611 )
2016
33
The management of cohesion in written narratives in students with specific language impairment: Differences between childhood and adolescence. ( 27668399 )
2016
34
Past participle formation in specific language impairment. ( 27321811 )
2016
35
Grammaticality and complexity of sentences in monolingual Spanish-speaking children with Specific Language Impairment. ( 27128985 )
2016
36
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying an Adequate Intensity and Variation in Treatment Response. ( 28036410 )
2016
37
Theory of mind and specific language impairment in school-age children. ( 27089201 )
2016
38
The role of social cognition and prosocial behaviour in relation to the socio-emotional functioning of primary aged children with specific language impairment. ( 26773217 )
2016
39
Theory of Mind Deficits and Social Emotional Functioning in Preschoolers with Specific Language Impairment. ( 27867370 )
2016
40
Examining the Language Phenotype in Children With Typical Development, Specific Language Impairment, and Fragile X Syndrome. ( 27618388 )
2016
41
Memory consolidation in children with specific language impairment: Delayed gains and susceptibility to interference in implicit sequence learning. ( 27615432 )
2016
42
How Language Is Embodied in Bilinguals and Children with Specific Language Impairment. ( 27582716 )
2016
43
Benefits of augmentative signs in word learning: Evidence from children who are deaf/hard of hearing and children with specific language impairment. ( 27668401 )
2016
44
Spontaneous Gesture Production and Lexical Abilities in Children With Specific Language Impairment in a Naming Task. ( 27537243 )
2016
45
Atypical audiovisual word processing in school-age children with a history of specific language impairment: an event-related potential study. ( 27597881 )
2016
46
Processing Binding Relations in Specific Language Impairment. ( 27788275 )
2016
47
Dose Schedule and Enhanced Conversational Recast Treatment for Children With Specific Language Impairment. ( 27701629 )
2016
48
An investigation of NFXL1, a gene implicated in a study of specific language impairment. ( 27053962 )
2016
49
Perception of Small Frequency Differences in Children with Auditory Processing Disorder or Specific Language Impairment. ( 27310407 )
2016
50
Social cognition makes an independent contribution to peer relations in children with Specific Language Impairment. ( 26745788 )
2016

Variations for Specific Language Impairment

Expression for Specific Language Impairment

Search GEO for disease gene expression data for Specific Language Impairment.

Pathways for Specific Language Impairment

GO Terms for Specific Language Impairment

Biological processes related to Specific Language Impairment according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 9.16 CNTNAP2 FOXP2
2 ATP hydrolysis coupled cation transmembrane transport GO:0099132 8.96 ATP13A4 ATP2C2
3 vocal learning GO:0042297 8.62 CNTNAP2 FOXP2

Molecular functions related to Specific Language Impairment according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium-transporting ATPase activity GO:0005388 8.62 ATP13A4 ATP2C2

Sources for Specific Language Impairment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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