MCID: SPC019
MIFTS: 30

Specific Language Impairment

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Specific Language Impairment

MalaCards integrated aliases for Specific Language Impairment:

Name: Specific Language Impairment 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060244
UMLS 69 C0454651

Summaries for Specific Language Impairment

Disease Ontology : 12 A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.

MalaCards based summary : Specific Language Impairment is related to childhood apraxia of speech and speech and communication disorders. An important gene associated with Specific Language Impairment is SLI1 (Specific Language Impairment QTL, 1), and among its related pathways/superpathways is Bile secretion. Affiliated tissues include testes and brain.

Related Diseases for Specific Language Impairment

Graphical network of the top 20 diseases related to Specific Language Impairment:



Diseases related to Specific Language Impairment

Symptoms & Phenotypes for Specific Language Impairment

Drugs & Therapeutics for Specific Language Impairment

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Effectiveness of Early Parent-Based Language Intervention Unknown status NCT00625261 Phase 3
2 A Comparison of Language Intervention Programs Completed NCT00033150 Phase 3
3 Accelerating Word Learning in Children With Language Impairment Recruiting NCT01829360 Phase 1, Phase 2
4 Sensory and Connectivity Abnormalities in Autism and Language Disorders Unknown status NCT00956579
5 Participant Database for Autism Research Studies Unknown status NCT00549731
6 Evaluating Treatment Efficacy of Two Syntactic Treatment Procedures for Children With Specific Language Impairment (SLI): A Randomized Controlled Trial Completed NCT01765348
7 Experimental Word Learning in Children With and Without Language Impairment Completed NCT00607334
8 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
9 Improving STEM Outcomes for Young Children With Language Learning Disabilities Recruiting NCT03438760
10 Characterization of Auditory Processing Involved in the Encoding of Speech Sounds Recruiting NCT02574299
11 Language and Motricity in Preterm School Age Children Recruiting NCT02811029

Search NIH Clinical Center for Specific Language Impairment

Genetic Tests for Specific Language Impairment

Anatomical Context for Specific Language Impairment

MalaCards organs/tissues related to Specific Language Impairment:

38
Testes, Brain

Publications for Specific Language Impairment

Articles related to Specific Language Impairment:

(show top 50) (show all 140)
# Title Authors Year
1
Exemplar Variability Facilitates Retention of Word Learning by Children With Specific Language Impairment. ( 29131888 )
2018
2
Direct object pronoun sentence processing in Spanish-English children with/without Specific Language Impairment and adults: A cross-modal priming study. ( 29426787 )
2018
3
Which Preschool Children With Specific Language Impairment Receive Language Intervention? ( 29188274 )
2018
4
Don't speak too fast! Processing of fast rate speech in children with specific language impairment. ( 29373610 )
2018
5
Is interference control in children with specific language impairment similar to that of children with autistic spectrum disorder? ( 29169021 )
2018
6
The Contributions of Phonological Awareness, Alphabet Knowledge, and Letter Writing to Name Writing in Children With Specific Language Impairment and Typically Developing Children. ( 29351353 )
2018
7
Comparison of Spontaneously Elicited Language Patterns in Specific Language Impairment and High-Functioning Autism. ( 29289438 )
2018
8
Retelling stories: Grammatical and lexical measures for identifying monolingual spanish speaking children with specific language impairment (SLI). ( 29274509 )
2018
9
The comparison of perceived health-related quality of life between Australian children with severe specific language impairment to age and gender-matched peers. ( 29444654 )
2018
10
Adults with Specific Language Impairment fail to consolidate speech sounds during sleep. ( 29253604 )
2018
11
Emotional and behavioural needs in children with specific language impairment and in children with autism spectrum disorder: The importance of pragmatic language impairment. ( 28886424 )
2017
12
Statistical word learning in children with autism spectrum disorder and specific language impairment. ( 28464253 )
2017
13
The Role of Frequency in Learning Morphophonological Alternations: Implications for Children With Specific Language Impairment. ( 28510615 )
2017
14
The relationship between information carrying words, memory and language skills in school age children with specific language impairment. ( 28672043 )
2017
15
Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment. ( 28440294 )
2017
16
Procedural Motor Learning in Children With Specific Language Impairment. ( 29090309 )
2017
17
With Some Help From Others' Hands: Iconic Gesture Helps Semantic Learning in Children With Specific Language Impairment. ( 29098283 )
2017
18
The Potential of Past Tense Marking in Oral Reading as a Clinical Marker of Specific Language Impairment in School-Age Children. ( 29222571 )
2017
19
A Preliminary Comparison of Reading Subtypes in a Clinical Sample of Children With Specific Language Impairment. ( 28820919 )
2017
20
Developmental Associations Between Working Memory and Language in Children With Specific Language Impairment: A Longitudinal Study. ( 29114769 )
2017
21
Hypertext comprehension of deaf and hard-of-hearing students and students with specific language impairment. ( 28073077 )
2017
22
Can you spell dyslexia without SLI? Comparing the cognitive profiles of dyslexia and specific language impairment and their roles in learning. ( 28486125 )
2017
23
Tracking the Growth of Tense and Agreement in Children With Specific Language Impairment: Differences Between Measures of Accuracy, Diversity, and Productivity. ( 29188270 )
2017
24
Third person singular -s in typical development and specific language impairment: Input and neighbourhood density. ( 28727489 )
2017
25
Case History Risk Factors for Specific Language Impairment: A Systematic Review and Meta-Analysis. ( 28672377 )
2017
26
Grammaticality differences between Spanish-speaking children with specific language impairment and their typically developing peers. ( 28421645 )
2017
27
Using Pupillometry to Investigate Sentence Comprehension in Children With and Without Specific Language Impairment. ( 28586855 )
2017
28
A Sentence Repetition Task for Catalan-Speaking Typically-Developing Children and Children with Specific Language Impairment. ( 29163261 )
2017
29
Applying an Integrative Framework of Executive Function to Preschoolers With Specific Language Impairment. ( 28724132 )
2017
30
Statistical Learning in Specific Language Impairment: A Meta-Analysis. ( 29149241 )
2017
31
Alliteration and rhyme skills in children with specific language impairment. ( 28380200 )
2017
32
Distributed Training Enhances Implicit Sequence Acquisition in Children With Specific Language Impairment. ( 28854315 )
2017
33
Low-level neural auditory discrimination dysfunctions in specific language impairment-A review on mismatch negativity findings. ( 29182947 )
2017
34
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying Adequate Progress and Successful Learning Patterns. ( 28419188 )
2017
35
The role of nonverbal working memory in morphosyntactic processing by children with specific language impairment and autism spectrum disorders. ( 28690687 )
2017
36
The development of writing skills in 4-year-old children with and without specific language impairment. ( 28481668 )
2017
37
Procedural learning in Parkinson's disease, specific language impairment, dyslexia, schizophrenia, developmental coordination disorder, and autism spectrum disorders: A second-order meta-analysis. ( 28710941 )
2017
38
Sensitivity to Audiovisual Temporal Asynchrony in Children With a History of Specific Language Impairment and Their Peers With Typical Development: A Replication and Follow-Up Study. ( 28715546 )
2017
39
Screening for Specific Language Impairment in Preschool Children: Evaluating a Screening Procedure Including the Token Test. ( 28474204 )
2017
40
Learning and Overnight Retention in Declarative Memory in Specific Language Impairment. ( 28046095 )
2017
41
Comprehension of ambiguity for children with Specific Language Impairment and Autism Spectrum Disorder. ( 27982253 )
2016
42
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying an Adequate Intensity and Variation in Treatment Response. ( 28036410 )
2016
43
Atypical audiovisual word processing in school-age children with a history of specific language impairment: an event-related potential study. ( 27597881 )
2016
44
Intrafamilial phenotypic variability of Specific Language Impairment. ( 27388785 )
2016
45
A Case of Specific Language Impairment in a Deaf Signer of American Sign Language. ( 27884866 )
2016
46
Theory of mind and specific language impairment in school-age children. ( 27089201 )
2016
47
How Language Is Embodied in Bilinguals and Children with Specific Language Impairment. ( 27582716 )
2016
48
Executive and intellectual functioning in school-aged children with specific language impairment. ( 27432160 )
2016
49
Intervention in reading processes in pupils with Specific Language Impairment (SLI). ( 26820422 )
2016
50
Diagnostic accuracy of repetition tasks for the identification of specific language impairment (SLI) in bilingual children: evidence from Russian and Hebrew. ( 26990037 )
2016

Variations for Specific Language Impairment

Expression for Specific Language Impairment

Search GEO for disease gene expression data for Specific Language Impairment.

Pathways for Specific Language Impairment

Pathways related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.65 ABCC4 ADCY4 CFTR

GO Terms for Specific Language Impairment

Biological processes related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP hydrolysis coupled cation transmembrane transport GO:0099132 9.16 ATP13A4 ATP2C2
2 ATP hydrolysis coupled anion transmembrane transport GO:0099133 8.96 ABCC4 CFTR
3 vocal learning GO:0042297 8.62 CNTNAP2 FOXP2

Molecular functions related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-transporting ATPase activity GO:0005388 8.96 ATP13A4 ATP2C2
2 ATPase-coupled anion transmembrane transporter activity GO:0043225 8.62 ABCC4 CFTR

Sources for Specific Language Impairment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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