MCID: SPC019
MIFTS: 28

Specific Language Impairment malady

Categories: Mental diseases, Genetic diseases

Aliases & Classifications for Specific Language Impairment

Aliases & Descriptions for Specific Language Impairment:

Name: Specific Language Impairment 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060244

Summaries for Specific Language Impairment

Disease Ontology : 12 A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.

MalaCards based summary : Specific Language Impairment is related to specific language impairment 5 and specific language impairment 4. An important gene associated with Specific Language Impairment is FOXP2 (Forkhead Box P2). The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia : 71 Specific language impairment (SLI) is diagnosed when a child\'s language does not develop normally and... more...

Related Diseases for Specific Language Impairment

Graphical network of the top 20 diseases related to Specific Language Impairment:



Diseases related to Specific Language Impairment

Symptoms & Phenotypes for Specific Language Impairment

Drugs & Therapeutics for Specific Language Impairment

Drugs for Specific Language Impairment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Memantine Approved, Investigational Phase 3 19982-08-2 4054
3
Ethanol Approved Phase 2, Phase 3 64-17-5 702
4 Hormones Phase 3
5 Antiparkinson Agents Phase 3,Phase 2
6 Dopamine Agents Phase 3,Phase 2
7 Excitatory Amino Acid Antagonists Phase 3
8 Excitatory Amino Acids Phase 3
9 Neurotransmitter Agents Phase 3,Phase 2
10 Oxytocics Phase 3
11 Atosiban Phase 3 90779-69-4
12 Hormone Antagonists Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Tocolytic Agents Phase 3
15 Vasoconstrictor Agents Phase 3
16 Vasotocin Phase 3
17 Anti-Infective Agents Phase 2, Phase 3
18 Anti-Infective Agents, Local Phase 2, Phase 3
19 Disinfectants Phase 2, Phase 3
20 Phenylethyl Alcohol Phase 2, Phase 3
21 Omega 3 Fatty Acid Nutraceutical Phase 3,Phase 2
22 Protective Agents Phase 2
23 Autonomic Agents Phase 2
24 Peripheral Nervous System Agents Phase 2
25 insulin Phase 2
26 Insulin, Globin Zinc Phase 2
27 Mitogens Phase 2
28 (3-aminopropyl)(n-butyl)phosphinic acid Phase 2
29 GABA Agents Phase 2
30 Neuroprotective Agents Phase 2
31 Catechol O-Methyltransferase Inhibitors Phase 2
32 Catechol Nutraceutical Phase 2
33
Lovastatin Approved, Investigational Phase 1 75330-75-5 53232
34 Anticholesteremic Agents Phase 1
35 Antimetabolites Phase 1
36 Dihydromevinolin Phase 1
37 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1
38 Hypolipidemic Agents Phase 1
39 L 647318 Phase 1
40 Lipid Regulating Agents Phase 1
41
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
42
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
43
Acetylcysteine Approved, Investigational 616-91-1 12035
44
Dextromethorphan Approved 125-71-3 5360696 5362449
45
Quinidine Approved 56-54-2 441074
46
Benzocaine Approved 1994-09-7, 94-09-7 2337
47
Donepezil Approved 120014-06-4 3152
48
Menthol Approved 2216-51-5 16666
49
Triamcinolone Approved, Vet_approved 124-94-7 31307
50
Copper Approved 15158-11-9, 7440-50-8 27099

Interventional clinical trials:

(show top 50) (show all 87)
id Name Status NCT ID Phase
1 Effectiveness of Early Parent-Based Language Intervention Unknown status NCT00625261 Phase 3
2 Feasibility of Omega-3 Supplementation for Children With Language Impairments Unknown status NCT01640106 Phase 3
3 Randomized Clinical Trial of Phonological Interventions Unknown status NCT00818428 Phase 2, Phase 3
4 A Comparison of Language Intervention Programs Completed NCT00033150 Phase 3
5 Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia Completed NCT00594737 Phase 3
6 Cochlear Implantation in Single Sided Deafness and Asymmetrical Hearing Loss: a Cost/Utility Study. Recruiting NCT02204618 Phase 3
7 Follow up Study to Assess Long Term Safety and Outcomes in Infants and Children Born to Mothers Participating in Retosiban Treatment Studies Recruiting NCT02292784 Phase 3
8 Reducing Agitation in People With Dementia: the Customized Activity Trial Active, not recruiting NCT01892579 Phase 3
9 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Terminated NCT00965419 Phase 2, Phase 3
10 Deep rTMS (Repetitive Transcranial Magnetic Stimulation)for Treatment of Autism Symptoms in Children. Unknown status NCT01388179 Phase 2
11 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
12 Omega-3 Fatty Acids For Treatment Of Young Children With Autism (OMG) Completed NCT01248728 Phase 2
13 Accelerating Word Learning in Children With Language Impairment Recruiting NCT01829360 Phase 1, Phase 2
14 Brain Stimulation and Aphasia Treatment Recruiting NCT01686373 Phase 2
15 A Pilot Treatment Study of Insulin-Like Growth Factor-1 (IGF-1) in Autism Spectrum Disorder Recruiting NCT01970345 Phase 2
16 Effects of Transcranial Direct Current Stimulation in Post-stroke Aphasia Recruiting NCT02622945 Phase 2
17 Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency Recruiting NCT02019667 Phase 2
18 Effects of Tolcapone on Frontotemporal Dementia Active, not recruiting NCT00604591 Phase 2
19 Preventing Learning Problems in Young Children: A Public Health and Physician-Based Outreach Unknown status NCT00110292 Phase 1
20 Transcranial Magnetic Stimulation to Improve Speech in Aphasia Completed NCT00608582 Phase 1
21 Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation Completed NCT01651884 Phase 1
22 Trial to Evaluate the Safety of Lovastatin in Individuals With Neurofibromatosis Type I (NF1) Completed NCT00352599 Phase 1
23 Sensory and Connectivity Abnormalities in Autism and Language Disorders Unknown status NCT00956579
24 Participant Database for Autism Research Studies Unknown status NCT00549731
25 Structural Connectivity as Imaging Endophenotypes of Autism Spectrum Disorders Unknown status NCT01513629
26 Functional Neuroimage in Assessment of Post-stroke Aphasia Unknown status NCT02120508
27 Computerised Therapy in Chronic Stroke Unknown status NCT01928602
28 Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls Unknown status NCT01147679
29 Women's Health Initiative Study of Cognitive Aging Unknown status NCT00631332
30 Evaluating Treatment Efficacy of Two Syntactic Treatment Procedures for Children With Specific Language Impairment (SLI): A Randomized Controlled Trial Completed NCT01765348
31 Experimental Word Learning in Children With and Without Language Impairment Completed NCT00607334
32 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
33 MR Scanning of Very Young Children With Severe Developmental Disorders Completed NCT00156221
34 Magnetoencephalographic (MEG) Evidence for Novel Metaphor Processing Among Schizophrenic Patients Completed NCT01325363
35 Functional MRI Study in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD) Completed NCT02393729
36 Study of Hierarchy of Afferents in Postural Control of Children With Dyslexia Completed NCT02879786
37 Translation & Linguistic Validation of Knee and Osteoarthritis Outcome Score (KOOS) Questionnaire in Marathi Language Completed NCT02514395
38 An Investigation of Constraint Induced Language Therapy for Aphasia Completed NCT00223847
39 Computational Tools for Early Diagnosis of Memory Disorders Completed NCT02050464
40 Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's Disease Completed NCT01095744
41 Language Treatment for Progressive Aphasia Completed NCT00957710
42 Dopamine Function in Developmental Stuttering Completed NCT00024960
43 Oxytocin and Social Cognition in Frontotemporal Dementia Completed NCT01002300
44 The Effect of Oral Candidiasis on the Speech Production, Feeding Skills, and Self-Concept of Children and Adolescents With Symptomatic HIV Infection Completed NCT00001448
45 COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE Completed NCT02860338
46 Treatment Study of Frontotemporal Dementia Completed NCT00088751
47 Neurobiology and Treatment of Reading Disability in NF-1 Completed NCT00624234
48 ADVANCE Study: Alzheimer Disease eVAluation iN Clinical PracticE Completed NCT01772095
49 The Effects of End-of-range Grade A+ Mobilization Following Acute Primary TKA Completed NCT02105857
50 Correlation of Phonation With Deglutition and Aspiration Risk in the ICU Patients - an Exploratory Study Completed NCT01011803

Search NIH Clinical Center for Specific Language Impairment

Genetic Tests for Specific Language Impairment

Anatomical Context for Specific Language Impairment

MalaCards organs/tissues related to Specific Language Impairment:

39
Brain

Publications for Specific Language Impairment

Articles related to Specific Language Impairment:

(show top 50) (show all 101)
id Title Authors Year
1
Hypertext comprehension of deaf and hard-of-hearing students and students with specific language impairment. ( 28073077 )
2017
2
Learning and Overnight Retention in Declarative Memory in Specific Language Impairment. ( 28046095 )
2017
3
Lexical conflict resolution in children with specific language impairment. ( 27135369 )
2016
4
Impact of specific language impairment and type of school on different language subsystems. ( 27652925 )
2016
5
Dose Schedule and Enhanced Conversational Recast Treatment for Children With Specific Language Impairment. ( 27701629 )
2016
6
Syntactic Versus Memory Accounts of the Sentence Comprehension Deficits of Specific Language Impairment: Looking Back, Looking Ahead. ( 27973643 )
2016
7
Atypical audiovisual word processing in school-age children with a history of specific language impairment: an event-related potential study. ( 27597881 )
2016
8
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying an Adequate Intensity and Variation in Treatment Response. ( 28036410 )
2016
9
Cross-linguistic transfer effects after phonologically based cognate therapy in a case of multilingual specific language impairment (SLI). ( 27377882 )
2016
10
Do Adolescents With Specific Language Impairment Understand Driving Terminology? ( 27603435 )
2016
11
Linguistic profiles of children with CI as compared with children with hearing or specific language impairment. ( 26864995 )
2016
12
Benefits of augmentative signs in word learning: Evidence from children who are deaf/hard of hearing and children with specific language impairment. ( 27668401 )
2016
13
Longitudinal trajectories of the representation and access to phonological information in bilingual children with specific language impairment. ( 27153201 )
2016
14
Implicit Spoken Words and Motor Sequences Learning Are Impaired in Children with Specific Language Impairment. ( 27063340 )
2016
15
Complex sentence profiles in children with Specific Language Impairment: Are they really atypical? ( 26876093 )
2016
16
Grammaticality and complexity of sentences in monolingual Spanish-speaking children with Specific Language Impairment. ( 27128985 )
2016
17
Specific Language Impairment: Evaluation and detection of differential psycholinguistic markers in phonology and morphosyntax in Spanish-speaking children. ( 27596962 )
2016
18
Comprehension of ambiguity for children with Specific Language Impairment and Autism Spectrum Disorder. ( 27982253 )
2016
19
Processing Binding Relations in Specific Language Impairment. ( 27788275 )
2016
20
A Proof of Concept Study of Function-Based Statistical Analysis of fNIRS Data: Syntax Comprehension in Children with Specific Language Impairment Compared to Typically-Developing Controls. ( 27375448 )
2016
21
Theory of mind and specific language impairment in school-age children. ( 27089201 )
2016
22
Epistemic uncertainty: Turkish children with specific language impairment and their comprehension of tense and aspect. ( 27074978 )
2016
23
Memory consolidation in children with specific language impairment: Delayed gains and susceptibility to interference in implicit sequence learning. ( 27615432 )
2016
24
Executive and intellectual functioning in school-aged children with specific language impairment. ( 27432160 )
2016
25
Visual-motor integration performance in children with severe specific language impairment. ( 27291941 )
2016
26
Executive functions and language in children with different subtypes of specific language impairment. ( 26971060 )
2016
27
Children with Specific Language Impairment and Their Families: A Future View of Nature Plus Nurture and New Technologies for Comprehensive Language Intervention Strategies. ( 27701707 )
2016
28
A Case of Specific Language Impairment in a Deaf Signer of American Sign Language. ( 27884866 )
2016
29
Perception of Small Frequency Differences in Children with Auditory Processing Disorder or Specific Language Impairment. ( 27310407 )
2016
30
Mirror-drawing skill in children with specific language impairment: Improving generalization by incorporating variability into the practice session. ( 27093974 )
2016
31
Statistical Learning in Specific Language Impairment and Autism Spectrum Disorder: A Meta-Analysis. ( 27602006 )
2016
32
Spontaneous Gesture Production and Lexical Abilities in Children With Specific Language Impairment in a Naming Task. ( 27537243 )
2016
33
The roles of cognitive and language abilities in predicting decoding and reading comprehension: comparisons of dyslexia and specific language impairment. ( 27848086 )
2016
34
Executive Functions in Children With Specific Language Impairment: A Meta-Analysis. ( 27653611 )
2016
35
A systematic review on diagnostic procedures for specific language impairment: The sensitivity and specificity issues. ( 27904612 )
2016
36
Past participle formation in specific language impairment. ( 27321811 )
2016
37
On-line processing and comprehension of direct object pronoun sentences in Spanish-speaking children with Specific Language Impairment. ( 27636190 )
2016
38
Intervention in reading processes in pupils with Specific Language Impairment (SLI). ( 26820422 )
2016
39
The management of cohesion in written narratives in students with specific language impairment: Differences between childhood and adolescence. ( 27668399 )
2016
40
Examining the Language Phenotype in Children With Typical Development, Specific Language Impairment, and Fragile X Syndrome. ( 27618388 )
2016
41
The role of social cognition and prosocial behaviour in relation to the socio-emotional functioning of primary aged children with specific language impairment. ( 26773217 )
2016
42
Theory of Mind Deficits and Social Emotional Functioning in Preschoolers with Specific Language Impairment. ( 27867370 )
2016
43
Phonological processing in children with specific language impairment with and without reading difficulties. ( 26992032 )
2016
44
Specific language impairment and developmental dyslexia: What are the boundaries? Data from Greek children. ( 26773216 )
2016
45
Health-Related Quality of Life for Children and Adolescents with Specific Language Impairment: A Cohort Study by a Learning Disabilities Reference Center. ( 27851795 )
2016
46
Connective processing by bilingual children and monolinguals with specific language impairment: distinct profiles. ( 26847820 )
2016
47
Diagnostic accuracy of repetition tasks for the identification of specific language impairment (SLI) in bilingual children: evidence from Russian and Hebrew. ( 26990037 )
2016
48
An investigation of NFXL1, a gene implicated in a study of specific language impairment. ( 27053962 )
2016
49
Oral morphosyntactic competence as a predictor of reading comprehension in children with specific language impairment. ( 26947426 )
2016
50
Temporally Regular Musical Primes Facilitate Subsequent Syntax Processing in Children with Specific Language Impairment. ( 27378833 )
2016

Variations for Specific Language Impairment

Expression for Specific Language Impairment

Search GEO for disease gene expression data for Specific Language Impairment.

Pathways for Specific Language Impairment

GO Terms for Specific Language Impairment

Biological processes related to Specific Language Impairment according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 9.16 CNTNAP2 FOXP2
2 ATP hydrolysis coupled cation transmembrane transport GO:0099132 8.96 ATP13A4 ATP2C2
3 vocal learning GO:0042297 8.62 CNTNAP2 FOXP2

Molecular functions related to Specific Language Impairment according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium-transporting ATPase activity GO:0005388 8.62 ATP13A4 ATP2C2

Sources for Specific Language Impairment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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