MCID: SPC004
MIFTS: 37

Specific Phobia malady

Neuronal diseases category

Summaries for Specific Phobia

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Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards: Specific Phobia, also known as phobia, specific, is related to panic disorder and phobic disorder. An important gene associated with Specific Phobia is PHOBS (Phobia, specific). The drugs gabapentin and gabapentin enacarbil and the compound pregabalin have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala.

Wikipedia:63 A specific phobia is a generic term for any kind of anxiety disorder that amounts to an unreasonable or... more...

Description from OMIM:46 608251

Aliases & Classifications for Specific Phobia

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Sources:
8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

specific phobia 8 10
phobia, specific 9 46
simple phobia 8 60
phobic anxiety disorder 60


External Ids:

Disease Ontology8 DOID:599
NCIt39 C35284
SNOMED-CT56 192396001, 54587008
OMIM46 608251
ICD1025 F40.2

Related Diseases for Specific Phobia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Specific Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder30.7MAOA
2phobic disorder10.5
3social phobia10.4
4anxiety disorder10.3
5agoraphobia10.3
6animal phobia10.2
7nosophobia10.2
8velocardiofacial syndrome10.1
9generalized anxiety disorder10.0
10major depressive disorder10.0
11cerebritis10.0
12obsessive-compulsive disorder10.0
13separation anxiety disorder10.0
14flying phobia10.0
15bipolar disorder10.0
16williams syndrome10.0
17toxic encephalopathy10.0MAOA
18borderline personality disorder10.0GOLPH3, MAOA
19migraine10.0GOLPH3, RNASE2, MAOA

Graphical network of diseases related to Specific Phobia:



Diseases related to specific phobia

Clinical Features for Specific Phobia

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46OMIM
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Clinical features from OMIM:

608251

Drugs & Therapeutics for Specific Phobia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Specific Phobia

Drug clinical trials:

Search ClinicalTrials for Specific Phobia

Search NIH Clinical Center for Specific Phobia

Search CenterWatch for Specific Phobia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Specific Phobia

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Anatomical Context for Specific Phobia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Specific Phobia:

32
Brain, Amygdala

Animal Models for Specific Phobia or affiliated genes

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Publications for Specific Phobia

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Sources:
50PubMed
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Articles related to Specific Phobia:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
2
The spread of fear: Symbolic generalization mediates graded threat-avoidance in specific phobia. (23701662)
2014
3
Autobiographical memories of vomiting in people with a specific phobia ofA vomiting (emetophobia). (22813942)
2013
4
Individual differences in cognitive reappraisal usage modulate the time course of brain activation during symptom provocation in specific phobia. (23937792)
2013
5
Acute anxiolytic effects of quetiapine during virtual reality exposure--a double-blind placebo-controlled trial in patients with specific phobia. (23375006)
2013
6
The emetophobia questionnaire (EmetQ-13): psychometric validation of a measure of specific phobia of vomiting (emetophobia). (24080612)
2013
7
Internet-delivered CBT for children with specific phobia: a pilot study. (24245708)
2013
8
Effects of Cognitive-Behavioral Therapy on Brain Responses to Subliminal and Supraliminal Threat and Their Functional Significance in Specific Phobia. (24393393)
2013
9
Meta-analysis of functional brain imaging in specific phobia. (23711114)
2013
10
A review and meta-analysis of the heritability of specific phobia subtypes and corresponding fears. (23774007)
2013
11
Neural substrates of defensive reactivity in two subtypes of specific phobia. (24174207)
2013
12
Abnormal eating behaviour in people with a specific phobia of vomiting (emetophobia). (22081507)
2012
13
Treatment sensitivity of implicit threat evaluation, avoidance tendency and visual working memory bias in specific phobia. (22266073)
2012
14
A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds. (20869844)
2011
15
Vigilance for threat interacts with amygdala responses to subliminal threat cues in specific phobia. (21601831)
2011
16
Fear factors: cross validation of specific phobia domains in a community-based sample of African American adults. (21315552)
2011
17
How specific is specific phobia? Different neural response patterns in two subtypes of specific phobia. (21316468)
2011
18
Specific phobia: a review of DSM-IV specific phobia and preliminary recommendations for DSM-V. (20099272)
2010
19
Internet delivered images for exposure in specific phobia, design considerations for self-directed therapy. (20543273)
2010
20
The context specificity of anxiety responses induced by chronic psychosocial stress in rats: a shift from anxiety to social phobia? (20392194)
2010
21
Symptoms of specific and generalized social phobia: an examination of discriminant validity and structural relations with mood and anxiety symptoms. (20412890)
2010
22
Dynamics of brain responses to phobic-related stimulation in specific phobia subtypes. (20950283)
2010
23
Predictors of specific phobia in young women: a prospective community study. (19815371)
2010
24
Specific phobia in youth: phenomenology and psychological characteristics. (20171334)
2010
25
Specific phobia in older adults: evidence from the national epidemiologic survey on alcohol and related conditions. (19390295)
2009
26
Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm. (19434621)
2009
27
Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. (16950220)
2007
28
Specificity of autobiographical memory in social phobia and major depression. (17472199)
2007
29
Epidemiology of specific phobia subtypes: findings from the Dresden Mental Health Study. (17157482)
2007
30
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (17898336)
2007
31
Treatment of specific phobia in older adults. (18044196)
2007
32
Specific phobia and comorbid depression: a closer look at the National Comorbidity Survey data. (17292703)
2007
33
Effects of cognitive-behavioral therapy on brain activation in specific phobia. (16087353)
2006
34
Specificity of cognitive structure in depression and social phobia: a comparison of interpersonal and achievement content. (16343641)
2006
35
Hypnotic trait and specific phobia: EEG and autonomic output during phobic stimulation. (16533670)
2006
36
Social phobia, anxiety, oppositional behavior, social skills, and self-concept in children with specific selective mutism, generalized selective mutism, and community controls. (16685476)
2006
37
Social phobia symptoms: prevalence, sociodemographic correlates, and overlap with specific phobia symptoms. (16905404)
2006
38
Specific phobia: a disorder of fear conditioning and extinction. (16641829)
2006
39
Disappearance of specific phobia after removal of ventricular glioblastoma. (15896233)
2005
40
Specific phobia of illness: search for a new subtype. (15149712)
2004
41
Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. (14625149)
2003
42
Clinical features of four DSM-IV-specific phobia subtypes. (12142850)
2002
43
Case study: disgust and a specific phobia of buttons. (12410081)
2002
44
Frequency, comorbidity, and psychosocial impairment of specific phobia in adolescents. (10802831)
2000
45
Specific phobia 10-16 years after treatment. (10604083)
1999
46
Response to hyperventilation and 5.5% CO2 inhalation of subjects with types of specific phobia, panic disorder, or no mental disorder. (9247394)
1997
47
John Holland: the near-death of a frightened sailor: specific phobia and suicide-related behavior. (9357086)
1997
48
Prediction of outcome in the treatment of specific phobia. A cross validation study. (8687362)
1996
49
Defence style and behaviour therapy outcome in a specific phobia. (8733221)
1996
50
Social phobia: a comparison of specific and generalized subtypes and avoidant personality disorder. (1583227)
1992

Genetic Variations for Specific Phobia

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Expression for genes affiliated with Specific Phobia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Specific Phobia

Search GEO for disease gene expression data for Specific Phobia.

Pathways for genes affiliated with Specific Phobia

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Compounds for genes affiliated with Specific Phobia

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank
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Compounds related to Specific Phobia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pregabalin59 44 1111.7MAOA, CACNA1E

GO Terms for genes affiliated with Specific Phobia

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Sources:
16Gene Ontology
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Biological processes related to Specific Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:0076269.7NPY1R, CACNA1E
2sensory perception of painGO:0192339.4NPY1R, CACNA1E

Products for genes affiliated with Specific Phobia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Specific Phobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet