MCID: SPC004
MIFTS: 37

Specific Phobia malady

Neuronal diseases category

Summaries for Specific Phobia

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Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards: Specific Phobia, also known as phobia, specific, is related to panic disorder and phobic disorder. An important gene associated with Specific Phobia is PHOBS (Phobia, specific). The drugs gabapentin and gabapentin enacarbil and the compound pregabalin have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala.

Wikipedia:63 A specific phobia is a generic term for any kind of anxiety disorder that amounts to an unreasonable or... more...

Description from OMIM:46 608251

Aliases & Classifications for Specific Phobia

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 9diseasecard, 46OMIM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

specific phobia 8 10
phobia, specific 9 46
simple phobia 8 60
phobic anxiety disorder 60


External Ids:

Disease Ontology8 DOID:599
NCIt39 C35284
SNOMED-CT56 192396001, 54587008
OMIM46 608251
ICD1025 F40.2

Related Diseases for Specific Phobia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Specific Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder30.7MAOA
2phobic disorder10.5
3social phobia10.4
4anxiety disorder10.3
5agoraphobia10.3
6animal phobia10.2
7nosophobia10.2
8velocardiofacial syndrome10.1
9generalized anxiety disorder10.0
10major depressive disorder10.0
11cerebritis10.0
12obsessive-compulsive disorder10.0
13separation anxiety disorder10.0
14flying phobia10.0
15bipolar disorder10.0
16williams syndrome10.0
17toxic encephalopathy10.0MAOA
18borderline personality disorder10.0GOLPH3, MAOA
19migraine10.0GOLPH3, RNASE2, MAOA

Graphical network of diseases related to Specific Phobia:



Diseases related to specific phobia

Clinical Features for Specific Phobia

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Sources:
46OMIM
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Clinical features from OMIM:

608251

Drugs & Therapeutics for Specific Phobia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Specific Phobia

Drug clinical trials:

Search ClinicalTrials for Specific Phobia

Search NIH Clinical Center for Specific Phobia

Search CenterWatch for Specific Phobia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Specific Phobia

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Anatomical Context for Specific Phobia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Specific Phobia:

32
Brain, Amygdala

Animal Models for Specific Phobia or affiliated genes

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Publications for Specific Phobia

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Sources:
50PubMed
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Articles related to Specific Phobia:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
CORTICO-LIMBIC RESPONSES TO MASKED AFFECTIVE FACES ACROSS PTSD, PANIC DISORDER, AND SPECIFIC PHOBIA. (23861215)
2013
2
Autobiographical memories of vomiting in people with a specific phobia ofA vomiting (emetophobia). (22813942)
2013
3
Optimal attentional focus during exposure in specific phobia: a meta-analysis. (24185091)
2013
4
A review and meta-analysis of the heritability of specific phobia subtypes and corresponding fears. (23774007)
2013
5
Neural substrates of defensive reactivity in two subtypes of specific phobia. (24174207)
2013
6
Functional neuroimaging in specific phobia. (22804970)
2012
7
Neuroimaging in specific phobia disorder: a systematic review of the literature. (22392396)
2012
8
Defensive mobilization in specific phobia: fear specificity, negative affectivity, and diagnostic prominence. (22386377)
2012
9
Specific phobia among U.S. adolescents: phenomenology and typology. (23108894)
2012
10
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. (22099954)
2012
11
Intrusive imagery in people with a specific phobia of vomiting. (21963889)
2012
12
Epidemiology of fears and specific phobia in adolescence: results from the Mexican Adolescent Mental Health Survey. (22401475)
2012
13
Intensive two-day cognitive-behavioral intervention decreases cortisol secretion in soldiers suffering from specific phobia to wear protective mask. (21600590)
2011
14
Specific phobia: a review of DSM-IV specific phobia and preliminary recommendations for DSM-V. (20099272)
2010
15
The prevalence of specific phobia and associated co-morbid features in children and adolescents. (20439148)
2010
16
Symptoms of specific and generalized social phobia: an examination of discriminant validity and structural relations with mood and anxiety symptoms. (20412890)
2010
17
Recognition of irrationality of fear and the diagnosis of social anxiety disorder and specific phobia in adults: implications for criteria revision in DSM-5. (20577989)
2010
18
Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia. (21132846)
2010
19
Specific phobia in older adults: evidence from the national epidemiologic survey on alcohol and related conditions. (19390295)
2009
20
Rates and predictors of remission in young women with specific phobia: a prospective community study. (19604666)
2009
21
Ambulatory assessment in panic disorder and specific phobia. (19947782)
2009
22
Escitalopram in specific phobia: results of a placebo-controlled pilot trial. (18208904)
2008
23
Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. (16950220)
2007
24
Prevalence of self-reported specific phobia symptoms in an Israeli sample of young conscripts. (17134869)
2007
25
The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (17335637)
2007
26
Specificity of interpretation and judgemental biases in social phobia versus depression. (17877867)
2007
27
Effects of cognitive-behavioral therapy on brain activation in specific phobia. (16087353)
2006
28
Shaping approach responses as intervention for specific phobia in a child with autism. (17236342)
2006
29
Social phobia, anxiety, oppositional behavior, social skills, and self-concept in children with specific selective mutism, generalized selective mutism, and community controls. (16685476)
2006
30
Neural mechanisms of automatic and direct processing of phobogenic stimuli in specific phobia. (16139812)
2006
31
Primary agoraphobia as a specific phobia. (17077449)
2006
32
Social phobia symptoms: prevalence, sociodemographic correlates, and overlap with specific phobia symptoms. (16905404)
2006
33
Specific phobia: a disorder of fear conditioning and extinction. (16641829)
2006
34
Disappearance of specific phobia after removal of ventricular glioblastoma. (15896233)
2005
35
Coherence and specificity of information-processing biases in depression and social phobia. (15311984)
2004
36
Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? (12547382)
2003
37
Specific phobia is a frequent non-motor feature in stiff man syndrome. (12640064)
2003
38
Fear, disgust, and information processing in specific phobia: the application of signal detection theory. (12396208)
2002
39
Thought suppression: specificity in agoraphobia versus broad impairment in social phobia? (11762427)
2002
40
Specific phobia of illness in the community. (12062137)
2002
41
Real-time monitoring of brain activity in patients with specific phobia during exposure therapy, employing a stereoscopic virtual environment. (11708726)
2001
42
Effect of distraction and coping style on in vivo exposure for specific phobia of spiders. (11579985)
2001
43
Double-blind placebo-controlled pilot study of paroxetine for specific phobia. (10805616)
2000
44
The structure of specific phobia symptoms among children and adolescents. (10458049)
1999
45
Specific phobia 10-16 years after treatment. (10604083)
1999
46
Visual avoidance in specific phobia. (9922558)
1999
47
Comorbidity of panic disorder with agoraphobia and specific phobia: relationship with the subtypes of specific phobia. (9406736)
1997
48
Heterogeneity among specific phobia types in DSM-IV. (9465442)
1997
49
Preconscious processing bias in specific phobia. (9009041)
1997
50
Cerebral correlates of anticipated fear: a PET study of specific phobia. (9003987)
1996

Genetic Variations for Specific Phobia

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Expression for genes affiliated with Specific Phobia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Specific Phobia

Search GEO for disease gene expression data for Specific Phobia.

Pathways for genes affiliated with Specific Phobia

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Compounds for genes affiliated with Specific Phobia

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank
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Compounds related to Specific Phobia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pregabalin59 44 1111.7MAOA, CACNA1E

GO Terms for genes affiliated with Specific Phobia

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Sources:
16Gene Ontology
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Biological processes related to Specific Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:0076269.7NPY1R, CACNA1E
2sensory perception of painGO:0192339.4NPY1R, CACNA1E

Products for genes affiliated with Specific Phobia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Specific Phobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet