MCID: SPC004
MIFTS: 34

Specific Phobia malady

Mental diseases category
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Summaries for Specific Phobia

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Disease Ontology:8 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards based summary: Specific Phobia, also known as phobia, specific, is related to panic disorder and social phobia. An important gene associated with Specific Phobia is PHOBS (Phobia, specific). The drugs gabapentin and paroxetine have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala.

Wikipedia:65 A specific phobia is any kind of anxiety disorder that amounts to an unreasonable or irrational fear... more...

Description from OMIM:46 608251

Aliases & Classifications for Specific Phobia

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Specific Phobia, Aliases & Descriptions:

Name: Specific Phobia 8 10
Phobia, Specific 9 46 62
 
Simple Phobia 8 62
Phobic Anxiety Disorder 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:599
OMIM46 608251
SNOMED-CT57 192396001, 54587008
NCIt39 C35284
ICD1025 F40.2

Related Diseases for Specific Phobia

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Diseases related to Specific Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder10.5
2social phobia10.4
3anxiety disorder10.4
4agoraphobia10.3
5nosophobia10.2
6blindness10.2
7major depressive disorder10.1
8velocardiofacial syndrome10.1
9bipolar disorder10.1
10generalized anxiety disorder10.1
11flying phobia10.1
12animal phobia10.1
13obsessive-compulsive disorder10.1
14separation anxiety disorder10.1
15cerebritis10.1
16autism spectrum disorder10.1
17williams syndrome10.1
18glioblastoma10.1
19chronic pain10.1

Graphical network of diseases related to Specific Phobia:



Diseases related to specific phobia

Symptoms for Specific Phobia

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Clinical features from OMIM:

608251

Drugs & Therapeutics for Specific Phobia

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Drug clinical trials:

Search ClinicalTrials for Specific Phobia

Search NIH Clinical Center for Specific Phobia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Specific Phobia

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Anatomical Context for Specific Phobia

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MalaCards organs/tissues related to Specific Phobia:

32
Brain, Amygdala

Animal Models for Specific Phobia or affiliated genes

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Publications for Specific Phobia

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Articles related to Specific Phobia:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Abolition of lifelong specific phobia: a novel therapeutic consequence of left mesial temporal lobectomy. (24460482)
2015
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
3
Reducing specific phobia/fear in young people with autism spectrum disorders (ASDs) through a virtual reality environment intervention. (24987957)
2014
4
Nausea in specific phobia of vomiting. (25379248)
2013
5
CORTICO-LIMBIC RESPONSES TO MASKED AFFECTIVE FACES ACROSS PTSD, PANIC DISORDER, AND SPECIFIC PHOBIA. (23861215)
2013
6
Autobiographical memories of vomiting in people with a specific phobia ofA vomiting (emetophobia). (22813942)
2013
7
Individual differences in cognitive reappraisal usage modulate the time course of brain activation during symptom provocation in specific phobia. (23937792)
2013
8
Acute anxiolytic effects of quetiapine during virtual reality exposure--a double-blind placebo-controlled trial in patients with specific phobia. (23375006)
2013
9
The emetophobia questionnaire (EmetQ-13): psychometric validation of a measure of specific phobia of vomiting (emetophobia). (24080612)
2013
10
Optimal attentional focus during exposure in specific phobia: a meta-analysis. (24185091)
2013
11
Internet-delivered CBT for children with specific phobia: a pilot study. (24245708)
2013
12
Effects of Cognitive-Behavioral Therapy on Brain Responses to Subliminal and Supraliminal Threat and Their Functional Significance in Specific Phobia. (24393393)
2013
13
Prevalence, correlates, and comorbidities of four DSM-IV specific phobia subtypes: results from the Korean Epidemiological Catchment Area study. (23374980)
2013
14
Functional neuroimaging in specific phobia. (22804970)
2012
15
Neuroimaging in specific phobia disorder: a systematic review of the literature. (22392396)
2012
16
Defensive mobilization in specific phobia: fear specificity, negative affectivity, and diagnostic prominence. (22386377)
2012
17
Abnormal eating behaviour in people with a specific phobia of vomiting (emetophobia). (22081507)
2012
18
Specific phobia among U.S. adolescents: phenomenology and typology. (23108894)
2012
19
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. (22099954)
2012
20
A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds. (20869844)
2011
21
Intensive two-day cognitive-behavioral intervention decreases cortisol secretion in soldiers suffering from specific phobia to wear protective mask. (21600590)
2011
22
Vigilance for threat interacts with amygdala responses to subliminal threat cues in specific phobia. (21601831)
2011
23
Arousal modulation of memory and amygdala-parahippocampal connectivity: a PET-psychophysiology study in specific phobia. (21729104)
2011
24
Specific phobia: a review of DSM-IV specific phobia and preliminary recommendations for DSM-V. (20099272)
2010
25
Internet delivered images for exposure in specific phobia, design considerations for self-directed therapy. (20543273)
2010
26
The prevalence of specific phobia and associated co-morbid features in children and adolescents. (20439148)
2010
27
Specific phobia in older adults: evidence from the national epidemiologic survey on alcohol and related conditions. (19390295)
2009
28
Rates and predictors of remission in young women with specific phobia: a prospective community study. (19604666)
2009
29
Ambulatory assessment in panic disorder and specific phobia. (19947782)
2009
30
Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. (16950220)
2007
31
Epidemiology of specific phobia subtypes: findings from the Dresden Mental Health Study. (17157482)
2007
32
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (17898336)
2007
33
Cephalalgiaphobia: a possible specific phobia of illness. (17361383)
2007
34
Prevalence of self-reported specific phobia symptoms in an Israeli sample of young conscripts. (17134869)
2007
35
The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (17335637)
2007
36
Effects of cognitive-behavioral therapy on brain activation in specific phobia. (16087353)
2006
37
Hypnotic trait and specific phobia: EEG and autonomic output during phobic stimulation. (16533670)
2006
38
Shaping approach responses as intervention for specific phobia in a child with autism. (17236342)
2006
39
Neural mechanisms of automatic and direct processing of phobogenic stimuli in specific phobia. (16139812)
2006
40
Specific phobia of illness: search for a new subtype. (15149712)
2004
41
Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? (12547382)
2003
42
Specific phobia is a frequent non-motor feature in stiff man syndrome. (12640064)
2003
43
Fear, disgust, and information processing in specific phobia: the application of signal detection theory. (12396208)
2002
44
Clinical features of four DSM-IV-specific phobia subtypes. (12142850)
2002
45
Real-time monitoring of brain activity in patients with specific phobia during exposure therapy, employing a stereoscopic virtual environment. (11708726)
2001
46
Double-blind placebo-controlled pilot study of paroxetine for specific phobia. (10805616)
2000
47
The structure of specific phobia symptoms among children and adolescents. (10458049)
1999
48
Specific phobia 10-16 years after treatment. (10604083)
1999
49
Evidence from three fearful samples for a poor insight type in specific phobia. (9750977)
1998
50
Comorbidity of panic disorder with agoraphobia and specific phobia: relationship with the subtypes of specific phobia. (9406736)
1997

Variations for Specific Phobia

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Expression for genes affiliated with Specific Phobia

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Expression patterns in normal tissues for genes affiliated with Specific Phobia

Search GEO for disease gene expression data for Specific Phobia.

Pathways for genes affiliated with Specific Phobia

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Compounds for genes affiliated with Specific Phobia

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GO Terms for genes affiliated with Specific Phobia

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Products for genes affiliated with Specific Phobia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Specific Phobia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet