MCID: SPC004
MIFTS: 36

Specific Phobia malady

Neuronal category

Summaries for Specific Phobia

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards: Specific Phobia, also known as phobia, specific, is related to panic disorder and social phobia. An important gene associated with Specific Phobia is PHOBS (Phobia, specific). The drugs gabapentin and gabapentin enacarbil and the compound pregabalin have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala.

Wikipedia:64 A specific phobia is a generic term for any kind of anxiety disorder that amounts to an unreasonable or... more...

Description from OMIM:47 608251

Aliases & Classifications for Specific Phobia

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

specific phobia 8 10
phobia, specific 9 47
simple phobia 8 61
phobic anxiety disorder 61


External Ids:

Disease Ontology8 DOID:599
NCIt40 C35284
SNOMED-CT57 192396001, 54587008
OMIM47 608251
ICD1025 F40.2

Related Diseases for Specific Phobia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Specific Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder30.7MAOA
2social phobia10.5
3anxiety disorder10.4
4agoraphobia10.3
5animal phobia10.2
6major depressive disorder10.1
7velocardiofacial syndrome10.1
8generalized anxiety disorder10.1
9obsessive-compulsive disorder10.1
10separation anxiety disorder10.1
11flying phobia10.1
12bipolar disorder10.1
13williams syndrome10.1
14chronic pain10.1
15toxic encephalopathy10.0MAOA
16borderline personality disorder10.0GOLPH3, MAOA
17migraine10.0GOLPH3, RNASE2, MAOA

Graphical network of diseases related to Specific Phobia:



Diseases related to specific phobia

Clinical Features for Specific Phobia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608251

Drugs & Therapeutics for Specific Phobia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Specific Phobia

Drug clinical trials:

Search ClinicalTrials for Specific Phobia

Search NIH Clinical Center for Specific Phobia

Search CenterWatch for Specific Phobia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Specific Phobia

Anatomical Context for Specific Phobia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Specific Phobia:

33
Brain, Amygdala

Animal Models for Specific Phobia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Specific Phobia

Sources:
51PubMed
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Articles related to Specific Phobia:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
2
CORTICO-LIMBIC RESPONSES TO MASKED AFFECTIVE FACES ACROSS PTSD, PANIC DISORDER, AND SPECIFIC PHOBIA. (23861215)
2013
3
Autobiographical memories of vomiting in people with a specific phobia ofA vomiting (emetophobia). (22813942)
2013
4
Individual differences in cognitive reappraisal usage modulate the time course of brain activation during symptom provocation in specific phobia. (23937792)
2013
5
Acute anxiolytic effects of quetiapine during virtual reality exposure--a double-blind placebo-controlled trial in patients with specific phobia. (23375006)
2013
6
Optimal attentional focus during exposure in specific phobia: a meta-analysis. (24185091)
2013
7
Internet-delivered CBT for children with specific phobia: a pilot study. (24245708)
2013
8
Meta-analysis of functional brain imaging in specific phobia. (23711114)
2013
9
A review and meta-analysis of the heritability of specific phobia subtypes and corresponding fears. (23774007)
2013
10
Neural substrates of defensive reactivity in two subtypes of specific phobia. (24174207)
2013
11
Neuroimaging in specific phobia disorder: a systematic review of the literature. (22392396)
2012
12
Defensive mobilization in specific phobia: fear specificity, negative affectivity, and diagnostic prominence. (22386377)
2012
13
Abnormal eating behaviour in people with a specific phobia of vomiting (emetophobia). (22081507)
2012
14
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. (22099954)
2012
15
Intrusive imagery in people with a specific phobia of vomiting. (21963889)
2012
16
Treatment sensitivity of implicit threat evaluation, avoidance tendency and visual working memory bias in specific phobia. (22266073)
2012
17
A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds. (20869844)
2011
18
Vigilance for threat interacts with amygdala responses to subliminal threat cues in specific phobia. (21601831)
2011
19
Fear factors: cross validation of specific phobia domains in a community-based sample of African American adults. (21315552)
2011
20
Specific phobia: a review of DSM-IV specific phobia and preliminary recommendations for DSM-V. (20099272)
2010
21
Symptoms of specific and generalized social phobia: an examination of discriminant validity and structural relations with mood and anxiety symptoms. (20412890)
2010
22
Predictors of specific phobia in young women: a prospective community study. (19815371)
2010
23
Specific phobia in older adults: evidence from the national epidemiologic survey on alcohol and related conditions. (19390295)
2009
24
Ambulatory assessment in panic disorder and specific phobia. (19947782)
2009
25
Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. (16950220)
2007
26
Specificity of autobiographical memory in social phobia and major depression. (17472199)
2007
27
Epidemiology of specific phobia subtypes: findings from the Dresden Mental Health Study. (17157482)
2007
28
Treatment of specific phobia in older adults. (18044196)
2007
29
Effects of cognitive-behavioral therapy on brain activation in specific phobia. (16087353)
2006
30
Hypnotic trait and specific phobia: EEG and autonomic output during phobic stimulation. (16533670)
2006
31
Social phobia, anxiety, oppositional behavior, social skills, and self-concept in children with specific selective mutism, generalized selective mutism, and community controls. (16685476)
2006
32
Social phobia symptoms: prevalence, sociodemographic correlates, and overlap with specific phobia symptoms. (16905404)
2006
33
Specific phobia: a disorder of fear conditioning and extinction. (16641829)
2006
34
Disappearance of specific phobia after removal of ventricular glioblastoma. (15896233)
2005
35
Coherence and specificity of information-processing biases in depression and social phobia. (15311984)
2004
36
Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? (12547382)
2003
37
Specific phobia is a frequent non-motor feature in stiff man syndrome. (12640064)
2003
38
Thought suppression: specificity in agoraphobia versus broad impairment in social phobia? (11762427)
2002
39
Specific phobia of illness in the community. (12062137)
2002
40
Effect of distraction and coping style on in vivo exposure for specific phobia of spiders. (11579985)
2001
41
Double-blind placebo-controlled pilot study of paroxetine for specific phobia. (10805616)
2000
42
Frequency, comorbidity, and psychosocial impairment of specific phobia in adolescents. (10802831)
2000
43
The structure of specific phobia symptoms among children and adolescents. (10458049)
1999
44
Specific phobia 10-16 years after treatment. (10604083)
1999
45
Visual avoidance in specific phobia. (9922558)
1999
46
Comorbidity of panic disorder with agoraphobia and specific phobia: relationship with the subtypes of specific phobia. (9406736)
1997
47
John Holland: the near-death of a frightened sailor: specific phobia and suicide-related behavior. (9357086)
1997
48
Prediction of outcome in the treatment of specific phobia. A cross validation study. (8687362)
1996
49
Cerebral correlates of anticipated fear: a PET study of specific phobia. (9003987)
1996
50
Defence style and behaviour therapy outcome in a specific phobia. (8733221)
1996

Genetic Variations for Specific Phobia

Expression for genes affiliated with Specific Phobia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Specific Phobia

Search GEO for disease gene expression data for Specific Phobia.

Pathways for genes affiliated with Specific Phobia

Compounds for genes affiliated with Specific Phobia

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank
See all sources

Compounds related to Specific Phobia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pregabalin60 45 1111.7MAOA, CACNA1E

GO Terms for genes affiliated with Specific Phobia

Sources:
16Gene Ontology
See all sources

Biological processes related to Specific Phobia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1locomotory behaviorGO:0076269.7NPY1R, CACNA1E
2sensory perception of painGO:0192339.4NPY1R, CACNA1E

Products for genes affiliated with Specific Phobia

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  • Lysates
  • Antibodies

Sources for Specific Phobia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet