MCID: SPC004
MIFTS: 33

Specific Phobia malady

Mental diseases category

Summaries for Specific Phobia

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Sources:
9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Disease Ontology:9 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards: Specific Phobia, also known as phobia, specific, is related to panic disorder and social phobia. An important gene associated with Specific Phobia is PHOBS (Phobia, specific). The drugs gabapentin and gabapentin enacarbil have been mentioned in the context of this disorder. Affiliated tissues include brain and amygdala.

Wikipedia:66 A specific phobia is a generic term for any kind of anxiety disorder that amounts to an unreasonable or... more...

Description from OMIM:48 608251

Aliases & Classifications for Specific Phobia

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 10diseasecard, 48OMIM, 41NCIt, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

specific phobia 9 11
phobia, specific 10 48
simple phobia 9 63
phobic anxiety disorder 63


External Ids:

Disease Ontology9 DOID:599
NCIt41 C35284
SNOMED-CT59 54587008, 192396001
OMIM48 608251
ICD1026 F40.2

Related Diseases for Specific Phobia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Specific Phobia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder10.5
2social phobia10.4
3anxiety disorder10.4
4agoraphobia10.3
5nosophobia10.2
6blindness10.2
7major depressive disorder10.1
8velocardiofacial syndrome10.1
9obsessive-compulsive disorder10.1
10separation anxiety disorder10.1
11animal phobia10.1
12flying phobia10.1
13cerebritis10.1
14generalized anxiety disorder10.1
15bipolar disorder10.1
16williams syndrome10.1
17chronic pain10.1

Graphical network of diseases related to Specific Phobia:



Diseases related to specific phobia

Symptoms for Specific Phobia

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Sources:
48OMIM
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Clinical features from OMIM:

608251

Drugs & Therapeutics for Specific Phobia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Specific Phobia

Drug clinical trials:

Search ClinicalTrials for Specific Phobia

Search NIH Clinical Center for Specific Phobia

Search CenterWatch for Specific Phobia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Specific Phobia

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Anatomical Context for Specific Phobia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Specific Phobia:

34
Brain, Amygdala

Animal Models for Specific Phobia or affiliated genes

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Publications for Specific Phobia

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Sources:
53PubMed
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Articles related to Specific Phobia:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
2
CORTICO-LIMBIC RESPONSES TO MASKED AFFECTIVE FACES ACROSS PTSD, PANIC DISORDER, AND SPECIFIC PHOBIA. (23861215)
2013
3
Autobiographical memories of vomiting in people with a specific phobia ofA vomiting (emetophobia). (22813942)
2013
4
Individual differences in cognitive reappraisal usage modulate the time course of brain activation during symptom provocation in specific phobia. (23937792)
2013
5
Acute anxiolytic effects of quetiapine during virtual reality exposure--a double-blind placebo-controlled trial in patients with specific phobia. (23375006)
2013
6
The emetophobia questionnaire (EmetQ-13): psychometric validation of a measure of specific phobia of vomiting (emetophobia). (24080612)
2013
7
Optimal attentional focus during exposure in specific phobia: a meta-analysis. (24185091)
2013
8
Internet-delivered CBT for children with specific phobia: a pilot study. (24245708)
2013
9
Effects of Cognitive-Behavioral Therapy on Brain Responses to Subliminal and Supraliminal Threat and Their Functional Significance in Specific Phobia. (24393393)
2013
10
Prevalence, correlates, and comorbidities of four DSM-IV specific phobia subtypes: results from the Korean Epidemiological Catchment Area study. (23374980)
2013
11
Meta-analysis of functional brain imaging in specific phobia. (23711114)
2013
12
Functional neuroimaging in specific phobia. (22804970)
2012
13
Neuroimaging in specific phobia disorder: a systematic review of the literature. (22392396)
2012
14
Defensive mobilization in specific phobia: fear specificity, negative affectivity, and diagnostic prominence. (22386377)
2012
15
Abnormal eating behaviour in people with a specific phobia of vomiting (emetophobia). (22081507)
2012
16
Specific phobia among U.S. adolescents: phenomenology and typology. (23108894)
2012
17
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. (22099954)
2012
18
A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds. (20869844)
2011
19
Intensive two-day cognitive-behavioral intervention decreases cortisol secretion in soldiers suffering from specific phobia to wear protective mask. (21600590)
2011
20
Vigilance for threat interacts with amygdala responses to subliminal threat cues in specific phobia. (21601831)
2011
21
Arousal modulation of memory and amygdala-parahippocampal connectivity: a PET-psychophysiology study in specific phobia. (21729104)
2011
22
Specific phobia: a review of DSM-IV specific phobia and preliminary recommendations for DSM-V. (20099272)
2010
23
Internet delivered images for exposure in specific phobia, design considerations for self-directed therapy. (20543273)
2010
24
The prevalence of specific phobia and associated co-morbid features in children and adolescents. (20439148)
2010
25
Specific phobia in older adults: evidence from the national epidemiologic survey on alcohol and related conditions. (19390295)
2009
26
Rates and predictors of remission in young women with specific phobia: a prospective community study. (19604666)
2009
27
Ambulatory assessment in panic disorder and specific phobia. (19947782)
2009
28
Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. (16950220)
2007
29
Epidemiology of specific phobia subtypes: findings from the Dresden Mental Health Study. (17157482)
2007
30
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (17898336)
2007
31
Cephalalgiaphobia: a possible specific phobia of illness. (17361383)
2007
32
Prevalence of self-reported specific phobia symptoms in an Israeli sample of young conscripts. (17134869)
2007
33
The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. (17335637)
2007
34
Effects of cognitive-behavioral therapy on brain activation in specific phobia. (16087353)
2006
35
Hypnotic trait and specific phobia: EEG and autonomic output during phobic stimulation. (16533670)
2006
36
Shaping approach responses as intervention for specific phobia in a child with autism. (17236342)
2006
37
Neural mechanisms of automatic and direct processing of phobogenic stimuli in specific phobia. (16139812)
2006
38
Disappearance of specific phobia after removal of ventricular glioblastoma. (15896233)
2005
39
Specific phobia of illness: search for a new subtype. (15149712)
2004
40
Pain anxiety among chronic pain patients: specific phobia or manifestation of anxiety sensitivity? (12547382)
2003
41
Specific phobia is a frequent non-motor feature in stiff man syndrome. (12640064)
2003
42
Fear, disgust, and information processing in specific phobia: the application of signal detection theory. (12396208)
2002
43
Clinical features of four DSM-IV-specific phobia subtypes. (12142850)
2002
44
Real-time monitoring of brain activity in patients with specific phobia during exposure therapy, employing a stereoscopic virtual environment. (11708726)
2001
45
Double-blind placebo-controlled pilot study of paroxetine for specific phobia. (10805616)
2000
46
The structure of specific phobia symptoms among children and adolescents. (10458049)
1999
47
Specific phobia 10-16 years after treatment. (10604083)
1999
48
Evidence from three fearful samples for a poor insight type in specific phobia. (9750977)
1998
49
Comorbidity of panic disorder with agoraphobia and specific phobia: relationship with the subtypes of specific phobia. (9406736)
1997
50
Prediction of outcome in the treatment of specific phobia. A cross validation study. (8687362)
1996

Variations for Specific Phobia

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Expression for genes affiliated with Specific Phobia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Specific Phobia

Search GEO for disease gene expression data for Specific Phobia.

Pathways for genes affiliated with Specific Phobia

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Compounds for genes affiliated with Specific Phobia

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GO Terms for genes affiliated with Specific Phobia

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Products for genes affiliated with Specific Phobia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Specific Phobia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet