MCID: SPR016
MIFTS: 30

Spermatic Cord Torsion malady

Categories: Reproductive diseases

Aliases & Classifications for Spermatic Cord Torsion

Aliases & Descriptions for Spermatic Cord Torsion:

Name: Spermatic Cord Torsion 12 42 14 69
Torsion of Testicle 12
Testicular Torsion 12
Torsion of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11996
ICD9CM 35 608.2 608.20
MeSH 42 D013086
NCIt 47 C26885
UMLS 69 C0037856

Summaries for Spermatic Cord Torsion

MalaCards based summary : Spermatic Cord Torsion, also known as torsion of testicle, is related to orchitis and ischemia. An important gene associated with Spermatic Cord Torsion is CATSPER1 (Cation Channel Sperm Associated 1), and among its related pathways/superpathways are Pertussis and AGE/RAGE pathway. The drugs Hormone Antagonists and Androgens have been mentioned in the context of this disorder. Affiliated tissues include testis and testes, and related phenotype is cellular.

Wikipedia : 71 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

Related Diseases for Spermatic Cord Torsion

Diseases related to Spermatic Cord Torsion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 orchitis 10.0
2 ischemia 10.0
3 sertoli cell tumor 10.0
4 charcot-marie-tooth disease, axonal, type 2w 10.0 BMP1 C1R
5 retroperitoneal sarcoma 10.0 CASP3 NOS3
6 urea cycle disorder 10.0 CASP3 SPTAN1
7 hydrocele 10.0
8 epididymo-orchitis 9.9
9 renal-hepatic-pancreatic dysplasia 9.9 INSL3 TWIST1
10 breast reconstruction 9.8 CASP3 SPTAN1
11 cryptorchidism 9.8
12 testicular infarct 9.8
13 hypoxia 9.8
14 purpura 9.7
15 splenic disease 9.7 CATSPER1 INSL3 NOS3 TWIST1
16 tracheal lymphoma 8.7 BMP1 C1R CASP3 CATSPER1 INSL3 NOS3

Graphical network of the top 20 diseases related to Spermatic Cord Torsion:



Diseases related to Spermatic Cord Torsion

Symptoms & Phenotypes for Spermatic Cord Torsion

MGI Mouse Phenotypes related to Spermatic Cord Torsion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.17 CASP3 CATSPER1 INSL3 NOS3 RFX2 SPTAN1

Drugs & Therapeutics for Spermatic Cord Torsion

Drugs for Spermatic Cord Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Androgens
3 Hormones
4 Hormones, Hormone Substitutes, and Hormone Antagonists
5 Estrogens
6 Follicle Stimulating Hormone

Interventional clinical trials:


id Name Status NCT ID Phase
1 Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared Thermography Unknown status NCT01079650
2 Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men Unknown status NCT00150163
3 Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion Recruiting NCT01812109
4 Quality of Life Among Testicular Cancer Survivors Recruiting NCT02304575

Search NIH Clinical Center for Spermatic Cord Torsion

Cochrane evidence based reviews: spermatic cord torsion

Genetic Tests for Spermatic Cord Torsion

Anatomical Context for Spermatic Cord Torsion

MalaCards organs/tissues related to Spermatic Cord Torsion:

39
Testis, Testes

Publications for Spermatic Cord Torsion

Articles related to Spermatic Cord Torsion:

(show top 50) (show all 53)
id Title Authors Year
1
Missed spermatic cord torsion in an old man. ( 24175049 )
2013
2
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. ( 22705745 )
2012
3
Subsequent alterations in the contractile property ofA the vas deferens according to duration of spermatic cord torsion. ( 21890132 )
2011
4
Spermatic cord knot: a clinical finding in patients with spermatic cord torsion. ( 22190915 )
2011
5
Experimental unilateral spermatic cord torsion: the effect of polypolymerase enzyme inhibitor on histopathological and biochemical changes in the early and late periods in the ipsilateral and contralateral testicles. ( 20579694 )
2010
6
The morphological evaluation of ipsilateral and contralateral vasa deferentia in a rat model of unilateral spermatic cord torsion. ( 19921213 )
2010
7
Protective effect of alpha-lipoic acid in experimental spermatic cord torsion. ( 17112702 )
2007
8
Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. ( 15051328 )
2004
9
Spermatic cord torsion with preserved testis perfusion: initial anatomical observations. ( 15538271 )
2004
10
Unilateral spermatic cord torsion without ipsilateral spermatogenetic material: effects on testicular blood flow and fertility potential. ( 14579109 )
2004
11
Sonographic diagnosis of acute spermatic cord torsion. Rotation of the cord: a key to the diagnosis. ( 12107581 )
2002
12
Spermatic cord torsion after testicular fixation. A different surgical approach and a revision of current techniques. ( 11807671 )
2001
13
The effect of methylene blue on histological damage after spermatic cord torsion in a rat model. ( 11446854 )
2001
14
Noradrenaline and nitrite-nitrate concentrations in the contralateral testes during ipsilateral spermatic cord torsion in the presence or absence of a testis and epididymis. ( 10368208 )
1999
15
DNA flow cytometry reveals depressed spermatogenetic activity in the contralateral testis within 24 h of ipsilateral spermatic cord torsion independently of the presence of the testis and epididymis. ( 9748690 )
1998
16
Influence of experimental spermatic cord torsion on the contralateral testis in rats. Evaluation of tissue free oxygen radical scavenger enzyme levels. ( 9253119 )
1997
17
Acute spermatic cord torsion alters the microcirculation of the contralateral testis. ( 7490885 )
1996
18
Serum creatine kinase enzyme levels in the early diagnosis of spermatic cord torsion. ( 9008324 )
1996
19
Is ipsilateral testis mandatory for the occurrence of contralateral intratesticular biochemical changes indicative of hypoxia after unilateral spermatic cord torsion? ( 8529740 )
1995
20
Spermatic cord torsion in adults. ( 7817170 )
1994
21
Is ipsilateral testis mandatory for contralateral testicular deterioration encountered following spermatic cord torsion? ( 7974914 )
1994
22
Variability of ischemia during spermatic cord torsion in the rat. ( 8126796 )
1994
23
Special imaging casebook. Neonatal spermatic cord torsion and testicular infarction. ( 7830162 )
1994
24
Spermatic cord torsion: loss of spermatogenesis despite return of blood flow. ( 8373967 )
1993
25
Spermatic cord torsion in an infant receiving human chorionic gonadotropin. ( 8103805 )
1993
26
The alterations of cellular metabolism in the contralateral testis following spermatic cord torsion in rats. ( 8326602 )
1993
27
Sonographic appearance of the torsion knot in spermatic cord torsion. ( 1414769 )
1992
28
The effect of polyethylene glycol-superoxide dismutase administration on histological damage following spermatic cord torsion. ( 1640536 )
1992
29
Color Doppler ultrasound compared to a radionuclide scanning of spermatic cord torsion in a canine model. ( 1846434 )
1991
30
Spermatic cord torsion. Contralateral testicular degeneration at various ages in the rat. ( 2086577 )
1990
31
Intrauterine spermatic cord torsion in the newborn: sonographic and pathologic correlation. ( 2243983 )
1990
32
The effect of various degrees of unilateral spermatic cord torsion on fertility in the rat. ( 2374208 )
1990
33
Spermatic cord torsion: effects of cyclosporine and prednisone on fertility and the contralateral testis in the rat. ( 2254174 )
1990
34
Spermatic cord torsion. ( 3813629 )
1987
35
Spermatic cord torsion in the neonate. ( 3476079 )
1987
36
Testicular salvage following spermatic cord torsion. ( 3559866 )
1987
37
Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion. ( 3944017 )
1986
38
Spermatic cord torsion. ( 3717988 )
1986
39
Histological changes occurring in the contralateral testes of prepubertal rats subjected to various durations of unilateral spermatic cord torsion. ( 3989935 )
1985
40
Spermatic cord torsion: diagnostic limitations. ( 2999690 )
1985
41
The effect of prepubertal spermatic cord torsion on subsequent fertility in rats. ( 6715258 )
1984
42
Spermatic cord block and manual reduction: primary treatment for spermatic cord torsion. ( 6492282 )
1984
43
Autoantibodies against Leydig cells in patients after spermatic cord torsion. ( 6362937 )
1984
44
Spermatic cord torsion in the neonate. ( 6827663 )
1983
45
Spermatic cord torsion and Sertoli cell tumor in a dog. ( 6138340 )
1983
46
Histological study of the removed testes of patients after acute monolateral spermatic cord torsion. ( 6666858 )
1983
47
Spermatic cord torsion following previous surgical fixation. ( 7143612 )
1982
48
Immunological and clinical study of patients after spermatic cord torsion. ( 7039415 )
1982
49
Spermatic cord torsion in a dog. ( 7207448 )
1981
50
Bilateral spermatic cord torsion in the neonate. ( 7420615 )
1980

Variations for Spermatic Cord Torsion

Expression for Spermatic Cord Torsion

Search GEO for disease gene expression data for Spermatic Cord Torsion.

Pathways for Spermatic Cord Torsion

Pathways related to Spermatic Cord Torsion according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.84 C1R CASP3
2 10.44 CASP3 NOS3

GO Terms for Spermatic Cord Torsion

Biological processes related to Spermatic Cord Torsion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 8.92 BMP1 CATSPER1 RFX2 TWIST1

Sources for Spermatic Cord Torsion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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