MCID: SPR016
MIFTS: 47

Spermatic Cord Torsion malady

Reproductive category

Summaries for Spermatic Cord Torsion

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

MalaCards: Spermatic Cord Torsion, also known as torsion of testis unspecified, is related to parkinson's disease and torsion dystonia. An important gene associated with Spermatic Cord Torsion is CHKB (choline kinase beta), and among its related pathways are Synthesis of 15-eicosatetraenoic acid derivatives and glutathione redox reactions I. The compounds gssg and diphenyleneiodonium have been mentioned in the context of this disorder. Affiliated tissues include testis and testis leydig, and related mouse phenotypes are muscle and nervous system.

Description from OMIM:47 187400

Aliases & Classifications for Spermatic Cord Torsion

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt, 27ICD9CM, 57SNOMED-CT, 35MeSH, 47OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

spermatic cord torsion 8 10 61
torsion of testis unspecified 8
torsion of spermatic cord 8
torsion of testis nos 8
torsion of testicle 8
testicular torsion 8
torsion of testis 8
torsion 61


External Ids:

Disease Ontology8 DOID:11996
NCIt40 C26885
ICD9CM27 608.20, 608.2
MeSH35 D013086
OMIM47 187400
ICD1025 N44

Related Diseases for Spermatic Cord Torsion

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spermatic Cord Torsion:



Diseases related to spermatic cord torsion

Clinical Features for Spermatic Cord Torsion

Sources:
47OMIM
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Clinical features from OMIM:

187400

Drugs & Therapeutics for Spermatic Cord Torsion

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Spermatic Cord Torsion

Drug clinical trials:

Search ClinicalTrials for Spermatic Cord Torsion

Search NIH Clinical Center for Spermatic Cord Torsion

Search CenterWatch for Spermatic Cord Torsion

Genetic Tests for Spermatic Cord Torsion

Anatomical Context for Spermatic Cord Torsion

Sources:
33MalaCards
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MalaCards organs/tissues related to Spermatic Cord Torsion:

33
Testis, Testis leydig

Animal Models for Spermatic Cord Torsion or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Spermatic Cord Torsion:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4TWIST1, NOS3, MAPT, CHKB, SOD2
2MP:00036317.6TWIST1, SOD2, CHKB, MAPT, GPX1, GPX4
3MP:00053847.2CAT, SOD2, MAPT, GPX1, GPX4, NOS3

Publications for Spermatic Cord Torsion

Sources:
51PubMed
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Articles related to Spermatic Cord Torsion:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. (22705745)
2012
2
Subsequent alterations in the contractile property ofA the vas deferens according to duration of spermatic cord torsion. (21890132)
2011
3
Spermatic cord knot: a clinical finding in patients with spermatic cord torsion. (22190915)
2011
4
The morphological evaluation of ipsilateral and contralateral vasa deferentia in a rat model of unilateral spermatic cord torsion. (19921213)
2010
5
Experimental unilateral spermatic cord torsion: the effect of polypolymerase enzyme inhibitor on histopathological and biochemical changes in the early and late periods in the ipsilateral and contralateral testicles. (20579694)
2010
6
Protective effect of alpha-lipoic acid in experimental spermatic cord torsion. (17112702)
2007
7
Spermatic cord torsion with preserved testis perfusion: initial anatomical observations. (15538271)
2004
8
Unilateral spermatic cord torsion without ipsilateral spermatogenetic material: effects on testicular blood flow and fertility potential. (14579109)
2004
9
Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. (15051328)
2004
10
The effect of methylene blue on histological damage after spermatic cord torsion in a rat model. (11446854)
2001
11
Spermatic cord torsion after testicular fixation. A different surgical approach and a revision of current techniques. (11807671)
2001
12
Influence of experimental spermatic cord torsion on the contralateral testis in rats. Evaluation of tissue free oxygen radical scavenger enzyme levels. (9253119)
1997
13
Serum creatine kinase enzyme levels in the early diagnosis of spermatic cord torsion. (9008324)
1996
14
Acute spermatic cord torsion alters the microcirculation of the contralateral testis. (7490885)
1996
15
Is ipsilateral testis mandatory for the occurrence of contralateral intratesticular biochemical changes indicative of hypoxia after unilateral spermatic cord torsion? (8529740)
1995
16
Is ipsilateral testis mandatory for contralateral testicular deterioration encountered following spermatic cord torsion? (7974914)
1994
17
Spermatic cord torsion in adults. (7817170)
1994
18
Variability of ischemia during spermatic cord torsion in the rat. (8126796)
1994
19
Special imaging casebook. Neonatal spermatic cord torsion and testicular infarction. (7830162)
1994
20
Spermatic cord torsion in an infant receiving human chorionic gonadotropin. (8103805)
1993
21
Spermatic cord torsion: loss of spermatogenesis despite return of blood flow. (8373967)
1993
22
The alterations of cellular metabolism in the contralateral testis following spermatic cord torsion in rats. (8326602)
1993
23
The effect of polyethylene glycol-superoxide dismutase administration on histological damage following spermatic cord torsion. (1640536)
1992
24
Sonographic appearance of the torsion knot in spermatic cord torsion. (1414769)
1992
25
Color Doppler ultrasound compared to a radionuclide scanning of spermatic cord torsion in a canine model. (1846434)
1991
26
The effect of various degrees of unilateral spermatic cord torsion on fertility in the rat. (2374208)
1990
27
Spermatic cord torsion: effects of cyclosporine and prednisone on fertility and the contralateral testis in the rat. (2254174)
1990
28
Intrauterine spermatic cord torsion in the newborn: sonographic and pathologic correlation. (2243983)
1990
29
Spermatic cord torsion. Contralateral testicular degeneration at various ages in the rat. (2086577)
1990
30
Colour Doppler imaging--a new method to differentiate torsion of the spermatic cord and epididymo-orchitis. (2406148)
1990
31
Spermatic cord torsion. (3813629)
1987
32
Testicular salvage following spermatic cord torsion. (3559866)
1987
33
Spermatic cord torsion in the neonate. (3476079)
1987
34
Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion. (3944017)
1986
35
Spermatic cord torsion: diagnostic limitations. (2999690)
1985
36
Autoantibodies against Leydig cells in patients after spermatic cord torsion. (6362937)
1984
37
The effect of prepubertal spermatic cord torsion on subsequent fertility in rats. (6715258)
1984
38
Spermatic cord block and manual reduction: primary treatment for spermatic cord torsion. (6492282)
1984
39
Spermatic cord torsion in the neonate. (6827663)
1983
40
Histological study of the removed testes of patients after acute monolateral spermatic cord torsion. (6666858)
1983
41
Spermatic cord torsion and Sertoli cell tumor in a dog. (6138340)
1983
42
Spermatic cord torsion following previous surgical fixation. (7143612)
1982
43
Immunological and clinical study of patients after spermatic cord torsion. (7039415)
1982
44
Spermatic cord torsion in a dog. (7207448)
1981
45
Bilateral spermatic cord torsion in the neonate. (7354546)
1980
46
Bilaterally enlarged testicles in a newborn: an atypical presentation of intrauterine spermatic cord torsion. (7191631)
1980
47
Bilateral spermatic cord torsion in the neonate. (7420615)
1980
48
Spermatic cord torsion in the newborn. (1273783)
1976
49
Scrotal aspiration: aid in early differentiation between torsion of spermatic cord and acute epididymo-orchitis. (4454109)
1974
50
Testicular torsion and acute epididymitis; procaine infiltration of the spermatic cord as an aid in differentiation. (13059627)
1953

Genetic Variations for Spermatic Cord Torsion

Expression for genes affiliated with Spermatic Cord Torsion

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spermatic Cord Torsion

Search GEO for disease gene expression data for Spermatic Cord Torsion.

Pathways for genes affiliated with Spermatic Cord Torsion

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 30KEGG
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Compounds for genes affiliated with Spermatic Cord Torsion

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Spermatic Cord Torsion according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1gssg4510.6CHKB
2diphenyleneiodonium4510.4SOD2
312-hpete4510.2GPX1, GPX4
4myxothiazol45 1111.0SOD2, GPX1
52,7-dichlorofluorescin diacetate459.9SOD2, CAT
6pyrogallol459.9CAT, SOD2
7propyl gallate459.9CAT, SOD2
8oxypurinol459.8NOS3, CAT
9ptio459.8NOS3, CAT
10dmpo459.8SOD2, CAT
11glutathion459.7CAT, SOD2
12onoo459.7SOD2, NOS3
133-amino-1,2,4-triazole459.7CAT, SOD2
14nitroglycerin45 1110.7SOD2, CHKB, NOS3
15zinc superoxide459.6CAT, SOD2, GPX1
168-oxo-dg459.6SOD2, CAT, GPX1
17buthionine sulfoximine459.6GPX1, CAT, SOD2
18glucose 6-phosphate45 2410.6CAT, GPX1, CHKB
19vitamin-e459.6GPX4, CAT, GPX1
20gamma-glutamylcysteine45 11 2411.6CAT, SOD2, GPX1
2112-hydroxyeicosatetraenoic acid459.5GPX4, GPX1
22dithiothreitol459.5GPX1, CAT, GPX4
23allopurinol45 50 1111.5CAT, SOD2, NOS3
24xanthine45 2410.4CAT, SOD2, NOS3
255-hpete45 2410.4GPX4, GPX1, GPX5
26Glutathione11 2410.4GPX4, GPX5, GPX1
27tert-butylhydroperoxide459.3CAT, SOD2, GPX1, GPX4
28selenite459.3SOD2, GPX4, GPX1, CAT
29manganese superoxide459.3CAT, SOD2, GPX4, GPX1
30sodium nitroprusside459.2NOS3, SOD2, CAT
31citrate459.2NOS3, CAT, SOD2, CHKB
32choline45 11 2411.1NOS3, MAPT, CHKB
33malondialdehyde459.1CAT, SOD2, CHKB, GPX1, GPX4
34alpha tocopherol459.1CAT, SOD2, CHKB, GPX1, GPX4
35menadione45 11 2411.0SOD2, MAPT, CAT, GPX1
364-hydroxynonenal45 2410.0SOD2, MAPT, CAT, GPX1
37iron45 2410.0CAT, SOD2, GPX4, GPX1
38ascorbic acid45 249.9CAT, NOS3, GPX4, CHKB, SOD2
39peroxynitrite458.9NOS3, GPX1, CHKB, SOD2, CAT
40h2o2458.8MAPT, GPX4, GPX1, CAT, CHKB
41nitric oxide45 11 2410.8NOS3, CHKB, SOD2, CAT, GPX1
42actinomycin d458.7SOD2, MAPT, CAT, NOS3
43superoxide45 249.6GPX4, NOS3, GPX1, CHKB, SOD2, CAT
44lactate458.5CAT, SOD2, CHKB, MAPT
45doxorubicin45 50 1110.5SOD2, CAT, MAPT, GPX1, NOS3
46estrogen458.4TWIST1, NOS3, GPX1, MAPT, CHKB
47n acetylcysteine458.4SOD2, CHKB, MAPT, GPX1, GPX4, CAT
48nadph45 249.4GPX4, GPX5, GPX1, SOD2, MAPT
49cysteine458.4CAT, SOD2, MAPT, CHKB, GPX1, GPX4
50selenium45 249.2CAT, GPX4, GPX5, SOD2, CHKB, GPX1

GO Terms for genes affiliated with Spermatic Cord Torsion

Sources:
16Gene Ontology
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Biological processes related to Spermatic Cord Torsion according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to selenium ionGO:0102699.9GPX1, SOD2
2lipoxygenase pathwayGO:0193729.9GPX4, GPX1
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9NOS3, GPX1
4UV protectionGO:0096509.8CAT, GPX1
5purine nucleotide catabolic processGO:0061959.8CAT, GPX1
6response to gamma radiationGO:0103329.6GPX1, SOD2
7response to hyperoxiaGO:0550939.6CAT, SOD2
8hydrogen peroxide catabolic processGO:0427449.6GPX1, CAT
9triglyceride metabolic processGO:0066419.3CAT, GPX1
10small molecule metabolic processGO:0442818.6NOS3, GPX4, GPX1, CHKB, CAT

Molecular functions related to Spermatic Cord Torsion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.5NOS3, CAT
2glutathione peroxidase activityGO:0046028.7GPX4, GPX5, GPX1

Products for genes affiliated with Spermatic Cord Torsion

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Sources for Spermatic Cord Torsion

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet