MCID: SPR016
MIFTS: 34

Spermatic Cord Torsion malady

Reproductive diseases category

Aliases & Classifications for Spermatic Cord Torsion

About this section

Aliases & Descriptions for Spermatic Cord Torsion:

Name: Spermatic Cord Torsion 10 12 65 36
Torsion of Testis Unspecified 10
Torsion of Spermatic Cord 10
Torsion of Testis Nos 10
 
Torsion of Testicle 10
Testicular Torsion 10
Torsion of Testis 10


Classifications:



External Ids:

Disease Ontology10 DOID:11996
ICD9CM29 608.2, 608.20
NCIt42 C26885
MeSH36 D013086
ICD1027 N44

Summaries for Spermatic Cord Torsion

About this section
Wikipedia:68 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

MalaCards based summary: Spermatic Cord Torsion, also known as torsion of testis unspecified, is related to sertoli cell tumor and ischemia. An important gene associated with Spermatic Cord Torsion is TWIST1 (Twist Family BHLH Transcription Factor 1), and among its related pathways are Selenium Metabolism and Selenoproteins and Detoxification of Reactive Oxygen Species. Affiliated tissues include testis and testes, and related mouse phenotypes are cellular and mortality/aging.

Related Diseases for Spermatic Cord Torsion

About this section

Graphical network of the top 20 diseases related to Spermatic Cord Torsion:



Diseases related to spermatic cord torsion

Symptoms for Spermatic Cord Torsion

About this section

Drugs & Therapeutics for Spermatic Cord Torsion

About this section

Drugs for Spermatic Cord Torsion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Follicle Stimulating Hormone145

Interventional clinical trials:

idNameStatusNCT IDPhase
1Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular TorsionRecruitingNCT01812109
2Quality of Life Among Testicular Cancer SurvivorsRecruitingNCT02304575
3Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish MenActive, not recruitingNCT00150163
4Diagnosis of Acute Appendicitis, Ovary Torsion and Inflammation, and Testicular Torsion and Inflammation by Infrared ThermographyNot yet recruitingNCT01079650

Search NIH Clinical Center for Spermatic Cord Torsion


Cochrane evidence based reviews: Spermatic Cord Torsion

Genetic Tests for Spermatic Cord Torsion

About this section

Anatomical Context for Spermatic Cord Torsion

About this section

MalaCards organs/tissues related to Spermatic Cord Torsion:

33
Testis, Testes

Animal Models for Spermatic Cord Torsion or affiliated genes

About this section

MGI Mouse Phenotypes related to Spermatic Cord Torsion:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.6CAT, GPX1, GPX4, NOS3, SPTAN1, TWIST1
2MP:00107687.2BMP1, CAT, GPX1, GPX4, NOS3, SPTAN1

Publications for Spermatic Cord Torsion

About this section

Articles related to Spermatic Cord Torsion:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Missed spermatic cord torsion in an old man. (24175049)
2013
2
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. (22705745)
2012
3
Subsequent alterations in the contractile property ofA the vas deferens according to duration of spermatic cord torsion. (21890132)
2011
4
Spermatic cord knot: a clinical finding in patients with spermatic cord torsion. (22190915)
2011
5
The morphological evaluation of ipsilateral and contralateral vasa deferentia in a rat model of unilateral spermatic cord torsion. (19921213)
2010
6
Experimental unilateral spermatic cord torsion: the effect of polypolymerase enzyme inhibitor on histopathological and biochemical changes in the early and late periods in the ipsilateral and contralateral testicles. (20579694)
2010
7
Spermatic cord torsion with preserved testis perfusion: initial anatomical observations. (15538271)
2004
8
Unilateral spermatic cord torsion without ipsilateral spermatogenetic material: effects on testicular blood flow and fertility potential. (14579109)
2004
9
Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. (15051328)
2004
10
Sonographic diagnosis of acute spermatic cord torsion. Rotation of the cord: a key to the diagnosis. (12107581)
2002
11
The effect of methylene blue on histological damage after spermatic cord torsion in a rat model. (11446854)
2001
12
Spermatic cord torsion after testicular fixation. A different surgical approach and a revision of current techniques. (11807671)
2001
13
Noradrenaline and nitrite-nitrate concentrations in the contralateral testes during ipsilateral spermatic cord torsion in the presence or absence of a testis and epididymis. (10368208)
1999
14
DNA flow cytometry reveals depressed spermatogenetic activity in the contralateral testis within 24 h of ipsilateral spermatic cord torsion independently of the presence of the testis and epididymis. (9748690)
1998
15
Influence of experimental spermatic cord torsion on the contralateral testis in rats. Evaluation of tissue free oxygen radical scavenger enzyme levels. (9253119)
1997
16
Serum creatine kinase enzyme levels in the early diagnosis of spermatic cord torsion. (9008324)
1996
17
Acute spermatic cord torsion alters the microcirculation of the contralateral testis. (7490885)
1996
18
Is ipsilateral testis mandatory for the occurrence of contralateral intratesticular biochemical changes indicative of hypoxia after unilateral spermatic cord torsion? (8529740)
1995
19
Is ipsilateral testis mandatory for contralateral testicular deterioration encountered following spermatic cord torsion? (7974914)
1994
20
Spermatic cord torsion in adults. (7817170)
1994
21
Variability of ischemia during spermatic cord torsion in the rat. (8126796)
1994
22
Spermatic cord torsion in an infant receiving human chorionic gonadotropin. (8103805)
1993
23
Spermatic cord torsion: loss of spermatogenesis despite return of blood flow. (8373967)
1993
24
The alterations of cellular metabolism in the contralateral testis following spermatic cord torsion in rats. (8326602)
1993
25
The effect of polyethylene glycol-superoxide dismutase administration on histological damage following spermatic cord torsion. (1640536)
1992
26
Sonographic appearance of the torsion knot in spermatic cord torsion. (1414769)
1992
27
Color Doppler ultrasound compared to a radionuclide scanning of spermatic cord torsion in a canine model. (1846434)
1991
28
The effect of various degrees of unilateral spermatic cord torsion on fertility in the rat. (2374208)
1990
29
Spermatic cord torsion: effects of cyclosporine and prednisone on fertility and the contralateral testis in the rat. (2254174)
1990
30
Intrauterine spermatic cord torsion in the newborn: sonographic and pathologic correlation. (2243983)
1990
31
Spermatic cord torsion. Contralateral testicular degeneration at various ages in the rat. (2086577)
1990
32
Spermatic cord torsion. (3813629)
1987
33
Testicular salvage following spermatic cord torsion. (3559866)
1987
34
Spermatic cord torsion in the neonate. (3476079)
1987
35
Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion. (3944017)
1986
36
Spermatic cord torsion. (3717988)
1986
37
Histological changes occurring in the contralateral testes of prepubertal rats subjected to various durations of unilateral spermatic cord torsion. (3989935)
1985
38
Spermatic cord torsion: diagnostic limitations. (2999690)
1985
39
Autoantibodies against Leydig cells in patients after spermatic cord torsion. (6362937)
1984
40
The effect of prepubertal spermatic cord torsion on subsequent fertility in rats. (6715258)
1984
41
Spermatic cord torsion in the neonate. (6827663)
1983
42
Histological study of the removed testes of patients after acute monolateral spermatic cord torsion. (6666858)
1983
43
Spermatic cord torsion and Sertoli cell tumor in a dog. (6138340)
1983
44
Spermatic cord torsion following previous surgical fixation. (7143612)
1982
45
Immunological and clinical study of patients after spermatic cord torsion. (7039415)
1982
46
Spermatic cord torsion in a dog. (7207448)
1981
47
Bilateral spermatic cord torsion in the neonate. (7354546)
1980
48
Bilaterally enlarged testicles in a newborn: an atypical presentation of intrauterine spermatic cord torsion. (7191631)
1980
49
Bilateral spermatic cord torsion in the neonate. (7420615)
1980
50
Spermatic cord torsion in the newborn. (1273783)
1976

Variations for Spermatic Cord Torsion

About this section

Expression for genes affiliated with Spermatic Cord Torsion

About this section
Search GEO for disease gene expression data for Spermatic Cord Torsion.

Pathways for genes affiliated with Spermatic Cord Torsion

About this section

Pathways related to Spermatic Cord Torsion according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GPX1, GPX4
2
Show member pathways
9.4CAT, GPX1
39.4CAT, GPX1
4
Show member pathways
9.1CAT, GPX1, NOS3
5
Show member pathways
9.0CAT, GPX1, GPX4
6
Show member pathways
9.0CAT, GPX1, GPX4

GO Terms for genes affiliated with Spermatic Cord Torsion

About this section

Biological processes related to Spermatic Cord Torsion according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.2GPX1, NOS3
2lipoxygenase pathwayGO:001937210.2GPX1, GPX4
3UV protectionGO:000965010.1CAT, GPX1
4purine nucleotide catabolic processGO:000619510.1CAT, GPX1
5response to reactive oxygen speciesGO:000030210.0CAT, GPX1
6arachidonic acid metabolic processGO:001936910.0GPX1, GPX4
7response to hydrogen peroxideGO:004254210.0CAT, GPX1
8cellular response to growth factor stimulusGO:00713639.9CAT, TWIST1
9purine nucleobase metabolic processGO:00061449.9CAT, GPX1
10triglyceride metabolic processGO:00066419.9CAT, GPX1
11hydrogen peroxide catabolic processGO:00427449.6CAT, GPX1
12in utero embryonic developmentGO:00017019.5INSL3, NOS3, TWIST1
13response to oxidative stressGO:00069799.2CAT, GPX1, GPX4
14spermatogenesisGO:00072838.9CATSPER1, GPX4, INSL3
15negative regulation of apoptotic processGO:00430668.7CAT, GPX1, INSL3, TWIST1
16oxidation-reduction processGO:00551148.3CAT, GPX1, GPX4, NOS3
17small molecule metabolic processGO:00442818.1BMP1, CAT, GPX1, GPX4, NOS3

Molecular functions related to Spermatic Cord Torsion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipid-hydroperoxide glutathione peroxidase activityGO:00470669.8GPX1, GPX4
2NADP bindingGO:00506619.6CAT, NOS3
3glutathione peroxidase activityGO:00046029.6GPX1, GPX4

Sources for Spermatic Cord Torsion

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet