MCID: SPR016
MIFTS: 49

Spermatic Cord Torsion malady

Reproductive diseases category

Summaries for Spermatic Cord Torsion

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Testicular torsion occurs when the spermatic cord (from which the testicle is suspended) twists, cutting... more...

MalaCards: Spermatic Cord Torsion, also known as torsion of testis unspecified, is related to ischemia and parkinson's disease. An important gene associated with Spermatic Cord Torsion is CHKB (choline kinase beta), and among its related pathways are Synthesis of 15-eicosatetraenoic acid derivatives and glutathione redox reactions I. The compounds gssg and diphenyleneiodonium have been mentioned in the context of this disorder. Affiliated tissues include testis and testes, and related mouse phenotypes are muscle and nervous system.

Description from OMIM:46 187400

Aliases & Classifications for Spermatic Cord Torsion

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

spermatic cord torsion 8 10 60
torsion of testis unspecified 8
torsion of spermatic cord 8
torsion of testis nos 8
torsion of testicle 8
testicular torsion 8
torsion of testis 8
torsion 60


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Disease Ontology8 DOID:11996
NCIt39 C26885
ICD9CM27 608.20, 608.2
MeSH34 D013086
OMIM46 187400
ICD1025 N44

Related Diseases for Spermatic Cord Torsion

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spermatic Cord Torsion:



Diseases related to spermatic cord torsion

Clinical Features for Spermatic Cord Torsion

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46OMIM
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Clinical features from OMIM:

187400

Drugs & Therapeutics for Spermatic Cord Torsion

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Spermatic Cord Torsion

Search CenterWatch for Spermatic Cord Torsion

Genetic Tests for Spermatic Cord Torsion

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Anatomical Context for Spermatic Cord Torsion

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32MalaCards
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MalaCards organs/tissues related to Spermatic Cord Torsion:

32
Testis, Testes

Animal Models for Spermatic Cord Torsion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spermatic Cord Torsion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4TWIST1, NOS3, MAPT, CHKB, SOD2
2MP:00036317.6TWIST1, SOD2, CHKB, MAPT, GPX1, GPX4
3MP:00053847.2CAT, SOD2, MAPT, GPX1, GPX4, NOS3

Publications for Spermatic Cord Torsion

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50PubMed
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Articles related to Spermatic Cord Torsion:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Missed spermatic cord torsion in an old man. (24175049)
2013
2
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. (22705745)
2012
3
Spermatic cord knot: a clinical finding in patients with spermatic cord torsion. (22190915)
2011
4
The morphological evaluation of ipsilateral and contralateral vasa deferentia in a rat model of unilateral spermatic cord torsion. (19921213)
2010
5
Experimental unilateral spermatic cord torsion: the effect of polypolymerase enzyme inhibitor on histopathological and biochemical changes in the early and late periods in the ipsilateral and contralateral testicles. (20579694)
2010
6
Protective effect of alpha-lipoic acid in experimental spermatic cord torsion. (17112702)
2007
7
Spermatic cord torsion with preserved testis perfusion: initial anatomical observations. (15538271)
2004
8
Unilateral spermatic cord torsion without ipsilateral spermatogenetic material: effects on testicular blood flow and fertility potential. (14579109)
2004
9
Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. (15051328)
2004
10
Sonographic diagnosis of acute spermatic cord torsion. Rotation of the cord: a key to the diagnosis. (12107581)
2002
11
The effect of methylene blue on histological damage after spermatic cord torsion in a rat model. (11446854)
2001
12
Spermatic cord torsion after testicular fixation. A different surgical approach and a revision of current techniques. (11807671)
2001
13
Noradrenaline and nitrite-nitrate concentrations in the contralateral testes during ipsilateral spermatic cord torsion in the presence or absence of a testis and epididymis. (10368208)
1999
14
DNA flow cytometry reveals depressed spermatogenetic activity in the contralateral testis within 24 h of ipsilateral spermatic cord torsion independently of the presence of the testis and epididymis. (9748690)
1998
15
Influence of experimental spermatic cord torsion on the contralateral testis in rats. Evaluation of tissue free oxygen radical scavenger enzyme levels. (9253119)
1997
16
Serum creatine kinase enzyme levels in the early diagnosis of spermatic cord torsion. (9008324)
1996
17
Is ipsilateral testis mandatory for the occurrence of contralateral intratesticular biochemical changes indicative of hypoxia after unilateral spermatic cord torsion? (8529740)
1995
18
Is ipsilateral testis mandatory for contralateral testicular deterioration encountered following spermatic cord torsion? (7974914)
1994
19
Spermatic cord torsion in adults. (7817170)
1994
20
Variability of ischemia during spermatic cord torsion in the rat. (8126796)
1994
21
Special imaging casebook. Neonatal spermatic cord torsion and testicular infarction. (7830162)
1994
22
Spermatic cord torsion in an infant receiving human chorionic gonadotropin. (8103805)
1993
23
The alterations of cellular metabolism in the contralateral testis following spermatic cord torsion in rats. (8326602)
1993
24
The effect of polyethylene glycol-superoxide dismutase administration on histological damage following spermatic cord torsion. (1640536)
1992
25
Sonographic appearance of the torsion knot in spermatic cord torsion. (1414769)
1992
26
Color Doppler ultrasound compared to a radionuclide scanning of spermatic cord torsion in a canine model. (1846434)
1991
27
The effect of various degrees of unilateral spermatic cord torsion on fertility in the rat. (2374208)
1990
28
Spermatic cord torsion: effects of cyclosporine and prednisone on fertility and the contralateral testis in the rat. (2254174)
1990
29
Intrauterine spermatic cord torsion in the newborn: sonographic and pathologic correlation. (2243983)
1990
30
Spermatic cord torsion. Contralateral testicular degeneration at various ages in the rat. (2086577)
1990
31
Spermatic cord torsion. (3813629)
1987
32
Testicular salvage following spermatic cord torsion. (3559866)
1987
33
Spermatic cord torsion in the neonate. (3476079)
1987
34
Spermatic cord torsion. (3717988)
1986
35
Histological changes occurring in the contralateral testes of prepubertal rats subjected to various durations of unilateral spermatic cord torsion. (3989935)
1985
36
Spermatic cord torsion: diagnostic limitations. (2999690)
1985
37
Spermatic cord block and manual reduction: primary treatment for spermatic cord torsion. (6492282)
1984
38
Spermatic cord torsion in the neonate. (6827663)
1983
39
Histological study of the removed testes of patients after acute monolateral spermatic cord torsion. (6666858)
1983
40
Spermatic cord torsion and Sertoli cell tumor in a dog. (6138340)
1983
41
Spermatic cord torsion following previous surgical fixation. (7143612)
1982
42
Immunological and clinical study of patients after spermatic cord torsion. (7039415)
1982
43
Spermatic cord torsion in a dog. (7207448)
1981
44
Bilateral spermatic cord torsion in the neonate. (7354546)
1980
45
Bilaterally enlarged testicles in a newborn: an atypical presentation of intrauterine spermatic cord torsion. (7191631)
1980
46
Bilateral spermatic cord torsion in the neonate. (7420615)
1980
47
Spermatic cord torsion in the newborn. (1273783)
1976
48
Scrotal aspiration: aid in early differentiation between torsion of spermatic cord and acute epididymo-orchitis. (4454109)
1974
49
Acute epididymitis vs. torsion of spermatic cord in military service. (14419700)
1960
50
Testicular torsion and acute epididymitis; procaine infiltration of the spermatic cord as an aid in differentiation. (13059627)
1953

Genetic Variations for Spermatic Cord Torsion

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Expression for genes affiliated with Spermatic Cord Torsion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spermatic Cord Torsion

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Pathways for genes affiliated with Spermatic Cord Torsion

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Spermatic Cord Torsion

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Spermatic Cord Torsion according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1gssg4410.6CHKB
2diphenyleneiodonium4410.4SOD2
312-hpete4410.2GPX1, GPX4
4myxothiazol44 1111.0GPX1, SOD2
52,7-dichlorofluorescin diacetate449.9SOD2, CAT
6pyrogallol449.9CAT, SOD2
7propyl gallate449.9CAT, SOD2
8oxypurinol449.8CAT, NOS3
9ptio449.8NOS3, CAT
10dmpo449.8SOD2, CAT
11glutathion449.7CAT, SOD2
12onoo449.7NOS3, SOD2
133-amino-1,2,4-triazole449.7SOD2, CAT
14nitroglycerin44 1110.7NOS3, CHKB, SOD2
15zinc superoxide449.6GPX1, SOD2, CAT
168-oxo-dg449.6GPX1, SOD2, CAT
17buthionine sulfoximine449.6GPX1, SOD2, CAT
18glucose 6-phosphate44 2410.6CAT, CHKB, GPX1
19vitamin-e449.6CAT, GPX1, GPX4
20gamma-glutamylcysteine44 11 2411.6CAT, SOD2, GPX1
2112-hydroxyeicosatetraenoic acid449.5GPX4, GPX1
22dithiothreitol449.5GPX4, GPX1, CAT
23allopurinol44 49 1111.5NOS3, SOD2, CAT
24xanthine44 2410.4NOS3, SOD2, CAT
255-hpete44 2410.4GPX1, GPX5, GPX4
26Glutathione11 2410.4GPX1, GPX5, GPX4
27tert-butylhydroperoxide449.3CAT, SOD2, GPX1, GPX4
28selenite449.3CAT, SOD2, GPX1, GPX4
29manganese superoxide449.3CAT, SOD2, GPX1, GPX4
30sodium nitroprusside449.2CAT, SOD2, NOS3
31citrate449.2CAT, SOD2, CHKB, NOS3
32choline44 11 2411.1NOS3, MAPT, CHKB
33malondialdehyde449.1CAT, SOD2, CHKB, GPX1, GPX4
34alpha tocopherol449.1CAT, SOD2, CHKB, GPX1, GPX4
35menadione44 11 2411.0GPX1, MAPT, SOD2, CAT
364-hydroxynonenal44 2410.0CAT, SOD2, MAPT, GPX1
37iron44 2410.0GPX4, GPX1, SOD2, CAT
38ascorbic acid44 249.9CAT, SOD2, CHKB, GPX4, NOS3
39peroxynitrite448.9CAT, SOD2, CHKB, GPX1, NOS3
40h2o2448.8GPX4, GPX1, MAPT, CHKB, CAT
41nitric oxide44 11 2410.8CAT, SOD2, CHKB, GPX1, NOS3
42actinomycin d448.7CAT, SOD2, MAPT, NOS3
43superoxide44 249.6CAT, SOD2, CHKB, GPX1, GPX4, NOS3
44lactate448.5CAT, SOD2, CHKB, MAPT
45doxorubicin44 49 1110.5CAT, SOD2, MAPT, GPX1, NOS3
46estrogen448.4CHKB, MAPT, GPX1, NOS3, TWIST1
47n acetylcysteine448.4CAT, SOD2, CHKB, MAPT, GPX1, GPX4
48nadph44 249.4SOD2, MAPT, GPX1, GPX5, GPX4
49cysteine448.4CAT, SOD2, CHKB, MAPT, GPX1, GPX4
50selenium44 249.2GPX4, GPX5, GPX1, CHKB, SOD2, CAT

GO Terms for genes affiliated with Spermatic Cord Torsion

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16Gene Ontology
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Biological processes related to Spermatic Cord Torsion according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1response to selenium ionGO:0102699.9GPX1, SOD2
2lipoxygenase pathwayGO:0193729.9GPX4, GPX1
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9NOS3, GPX1
4UV protectionGO:0096509.8CAT, GPX1
5purine nucleotide catabolic processGO:0061959.8CAT, GPX1
6response to gamma radiationGO:0103329.6GPX1, SOD2
7response to hyperoxiaGO:0550939.6CAT, SOD2
8hydrogen peroxide catabolic processGO:0427449.6GPX1, CAT
9triglyceride metabolic processGO:0066419.3CAT, GPX1
10small molecule metabolic processGO:0442818.6NOS3, GPX4, GPX1, CHKB, CAT

Molecular functions related to Spermatic Cord Torsion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.5NOS3, CAT
2glutathione peroxidase activityGO:0046028.7GPX4, GPX5, GPX1

Products for genes affiliated with Spermatic Cord Torsion

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Sources for Spermatic Cord Torsion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet