MCID: SPR017
MIFTS: 33

Spermatocele

Categories: Reproductive diseases

Aliases & Classifications for Spermatocele

MalaCards integrated aliases for Spermatocele:

Name: Spermatocele 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11997
ICD9CM 34 608.1
MeSH 41 D013088
UMLS 69 C0037859

Summaries for Spermatocele

MalaCards based summary : Spermatocele is related to hydrocele and renal adenoma. An important gene associated with Spermatocele is SLC26A3 (Solute Carrier Family 26 Member 3), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, prostate and kidney, and related phenotype is endocrine/exocrine gland.

Wikipedia : 72 Spermatocele (/spɜːrˈmætəsiːl/) is a retention cyst of a tubule of the rete testis or the head of the... more...

Related Diseases for Spermatocele

Diseases related to Spermatocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 hydrocele 10.7
2 renal adenoma 10.4 NCAM1 PAX2
3 esophageal neuroendocrine tumor 10.4 NCAM1 SYP
4 ovarian large-cell neuroendocrine carcinoma 10.4 NCAM1 SYP
5 cutaneous ganglioneuroma 10.4 NCAM1 SYP
6 gallbladder small cell carcinoma 10.4 NCAM1 SYP
7 orbital cancer 10.4 NCAM1 SYP
8 pancreatic endocrine carcinoma 10.4 NCAM1 SYP
9 hypoganglionosis 10.4 NCAM1 SYP
10 conventional angiosarcoma 10.4 NCAM1 SYP
11 supratentorial primitive neuroectodermal tumor 10.4 NCAM1 SYP
12 endometrial small cell carcinoma 10.4 NCAM1 SYP
13 ureter, cancer of 10.4 SYP TERT
14 mediastinal cancer 10.4 NCAM1 SYP
15 subependymoma 10.4 NCAM1 SYP
16 angiomyoma 10.3 NCAM1 SYP
17 gastric squamous cell carcinoma 10.3 NCAM1 SYP
18 gastric small cell carcinoma 10.3 NCAM1 SYP
19 water-clear cell adenoma 10.3 SYP TG
20 atypical follicular adenoma 10.3 SYP TG
21 small cell neuroendocrine carcinoma 10.3 NCAM1 SYP
22 malignant teratoma 10.3 SYP TG
23 kidney benign neoplasm 10.3 MME PAX2
24 osmotic diarrhea 10.3 MME SLC26A3
25 orbital plasma cell granuloma 10.3 MME NCAM1
26 ovarian serous adenofibroma 10.3 CALB2 NCAM1
27 fallopian tube carcinosarcoma 10.3 CALB2 NCAM1
28 ovarian serous cystadenofibroma 10.3 CALB2 NCAM1
29 venous hemangioma 10.3 CALB2 SYP
30 endometrial mucinous adenocarcinoma 10.3 PAX2 PGR
31 fallopian tube endometrioid adenocarcinoma 10.2 CALB2 MME
32 mucinous ovarian cystadenoma 10.2 CALB2 SYP
33 malignant leydig cell tumor 10.2 CALB2 MME
34 cervix small cell carcinoma 10.2 NCAM1 SYP
35 adenofibroma 10.2 CALB2 MME
36 adrenal rest tumor 10.2 NCAM1 NR5A1 SYP
37 fallopian tube adenocarcinoma 10.2 CALB2 MME
38 peroneal neuropathy 10.2 MME TNF
39 papillary thymic adenocarcinoma 10.2 CALB2 TG
40 chronic orbital inflammation 10.2 MME NCAM1
41 rete testis adenocarcinoma 10.2 CALB2 MME
42 sella turcica neoplasm 10.2 PGR SYP
43 lung meningioma 10.2 NCAM1 PGR
44 soft tissue sarcoma 10.2 TERT TNF
45 tuberculum sellae meningioma 10.2 PGR SYP
46 denys-drash syndrome 10.2 NR5A1 PAX2
47 glycogen-rich clear cell breast carcinoma 10.2 PGR SYP
48 nephrogenic adenofibroma 10.2 MME NCAM1 PAX2
49 benign breast phyllodes tumor 10.2 MME PGR
50 cervical carcinosarcoma 10.1 MME PGR

Comorbidity relations with Spermatocele via Phenotypic Disease Network (PDN):


Bladder Neck Obstruction Prostate Cancer
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Spermatocele:



Diseases related to Spermatocele

Symptoms & Phenotypes for Spermatocele

MGI Mouse Phenotypes related to Spermatocele:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 NR5A1 PAX2 PGR SLC26A3 TERT TG

Drugs & Therapeutics for Spermatocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of DA-9401 on Improvement of Sperm Motility Recruiting NCT03258437

Search NIH Clinical Center for Spermatocele

Cochrane evidence based reviews: spermatocele

Genetic Tests for Spermatocele

Anatomical Context for Spermatocele

MalaCards organs/tissues related to Spermatocele:

38
Testis, Prostate, Kidney

Publications for Spermatocele

Articles related to Spermatocele:

(show top 50) (show all 67)
# Title Authors Year
1
131I Whole-Body Scan Incidental Uptake Due to Spermatocele. ( 28902733 )
2017
2
Spermatocele in a South African Boerboel dog. ( 26041595 )
2015
3
Tubular Ectasia of Rete Testis with Spermatocele. ( 26816970 )
2015
4
Routine Pathology Evaluation of Hydrocele and Spermatocele Specimens is Associated with Significant Costs and No Identifiable Benefit. ( 24768992 )
2014
5
Presence of benign germ cells in a fine needle aspirate of a spermatocele. ( 22045691 )
2013
6
Spermatocele following kidney transplant. ( 22487000 )
2012
7
Adult hydrocele and spermatocele. ( 21592287 )
2011
8
Extra scrotal spermatocele causing lower abdominal pain: a first case report. ( 20674226 )
2011
9
A randomized trial comparing 2 doses of polidocanol sclerotherapy for hydrocele or spermatocele. ( 21849198 )
2011
10
Small blue cells mimicking small cell carcinoma in spermatocele and hydrocele specimens: a report of 5 cases. ( 19740515 )
2010
11
Spermiophages in a giant spermatocele. ( 19941373 )
2010
12
Male fertility after spermatocele formation from tunica vaginalis in patients with bilateral vas agenesis. ( 18580017 )
2008
13
Spermatocele presenting as acute scrotum. ( 18825632 )
2008
14
Giant spermatocele mimicking hydrocele: a case report. ( 17606432 )
2007
15
Bilateral spermatocele concurrent with bilateral scrotal hydrocele presenting huge scrotal swelling. ( 18018592 )
2007
16
Theriogenology question of the month. Seminoma, spermatocele, sustentacular cell tumor. ( 15906562 )
2005
17
Spermatocele: a rare complication of rectal surgery and radiotherapy. Case report. ( 15154581 )
2004
18
What causes a spermatocele, and how is it usually removed? ( 15132122 )
2004
19
Primary bilateral spermatocele. ( 12534930 )
2003
20
Retrieval and cryopreservation of sperm from spermatocele fluid. ( 12597959 )
2003
21
Pro-inflammatory cytokine response of the fluid contents of spermatoceles and epididymal cysts. ( 11966578 )
2002
22
Torsion of spermatocele: a rare manifestation. ( 12187053 )
2002
23
Multilocular spermatocele: a case report. ( 11583363 )
2001
24
Spermatocele in a common noctule (Nyctalus noctula). ( 10638800 )
1999
25
Synergistic action of steroids and spermatocele fluid on in vitro proliferation of prostate stroma. ( 9598570 )
1998
26
Intratesticular spermatocele. ( 9610575 )
1998
27
Torsion of spermatocele and aplasia of the vas deferens. A case report. ( 9165262 )
1997
28
Percutaneous sperm aspiration of a spermatocele for intracytoplasmic sperm injection. ( 9302159 )
1997
29
Torsion of a spermatocele. ( 7500478 )
1995
30
Development of a new alloplastic spermatocele demonstrating successful sperm retrieval in an animal model. ( 7789555 )
1995
31
Alloplastic spermatocele: 20 years experience and perspectives. ( 7618373 )
1994
32
Congenital absence of vas deferens treated by artificial spermatocele constructed from the tunica vaginalis; report of six cases. ( 8272538 )
1993
33
Effect of spermatocele fluid on growth of human prostatic cells in culture. ( 8226302 )
1993
34
Clinical experience and successful impregnation using an artificial spermatocele. ( 1771703 )
1991
35
Torsion of a spermatocele: a case report and review of the literature. ( 2313807 )
1990
36
In vitro fertilization with spermatozoa from alloplastic spermatocele. ( 2318332 )
1990
37
Artificial spermatocele persisting for 14 years. ( 2398578 )
1990
38
Fertilization of human oocytes by spermatozoa from an artificial spermatocele. ( 3788432 )
1986
39
Alloplastic spermatocele. ( 3735514 )
1986
40
Implantation of artificial spermatocele with cup-shaped prosthesis for excretory azoospermia and chemical management of aspirated spermatozoa. ( 3745009 )
1986
41
Alloplastic spermatocele: poor sperm motility in intraoperative epididymal fluid contraindicates prosthesis implantation. ( 3735504 )
1986
42
Alloplastic spermatocele in cases of vasa aplasia. ( 4051632 )
1985
43
Torsion of spermatocele: a newly described entity with 2 case reports. ( 3981724 )
1985
44
Properties of human epididymal sperm obtained from an alloplastic spermatocele: motility assessment and penetration of zona-free hamster oocytes in the presence and absence of caffeine. ( 4029429 )
1985
45
Clinical experience with an artificial spermatocele. ( 6469865 )
1984
46
A new type of alloplastic spermatocele: the bridge spermatocele. ( 6708803 )
1984
47
Alloplastic spermatocele: diffusion across the allograft material and survival of spermatozoa in vitro and in vivo. ( 6471203 )
1984
48
Artificial spermatocele inserted onto the vas deferens: a clinical report. ( 6367333 )
1983
49
Outpatient hydrocele and spermatocele repair under local anesthesia. ( 6348308 )
1983
50
KelAcmi-Affeld alloplastic spermatocele and successful human delivery. ( 7324302 )
1981

Variations for Spermatocele

Expression for Spermatocele

Search GEO for disease gene expression data for Spermatocele.

Pathways for Spermatocele

GO Terms for Spermatocele

Cellular components related to Spermatocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 MME SYP

Biological processes related to Spermatocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.96 TERT TNF
2 replicative senescence GO:0090399 8.62 MME TERT

Sources for Spermatocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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