MCID: SPR017
MIFTS: 36

Spermatocele malady

Reproductive category

Summaries for Spermatocele

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Spermatocele (/spɜrˈmætəsiːl/) is a retention[disambiguation needed]cyst of a tubule of the rete... more...

MalaCards: Spermatocele is related to infertility and azoospermia. An important gene associated with Spermatocele is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are ATF-2 transcription factor network and Legionellosis. The compounds troglitazone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and testis, and related mouse phenotype endocrine/exocrine gland.

Aliases & Classifications for Spermatocele

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

spermatocele 8 45 61


External Ids:

Disease Ontology8 DOID:11997
ICD9CM27 608.1
NCIt40 C3865
MeSH35 D013088
ICD1025 N43.4

Related Diseases for Spermatocele

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spermatocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.2DDX4
2azoospermia10.2
3small cell carcinoma10.0
4von hippel-lindau disease10.0
5renal cysts and diabetes syndrome10.0
6diarrhea10.0SLC26A3
7arthropathy10.0TNF
8toxic shock syndrome10.0TNF
9familial mediterranean fever10.0TNF
10interstitial lung disease10.0TNF
11psoriatic arthritis10.0TNF
12uveitis10.0TNF
13diastrophic dysplasia10.0SLC26A3
14adenoma10.0SLC26A3
15bacterial vaginosis10.0IL8
16vasculitis10.0TNF
17bronchiolitis obliterans10.0IL8
18mastitis10.0IL8
19duodenal ulcer10.0IL8
20bronchiectasis10.0IL8
21peptic ulcer10.0IL8
22bronchopulmonary dysplasia10.0IL8
23proliferative diabetic retinopathy10.0IL8
24sarcoidosis10.0TNF
25common cold10.0IL8
26gastritis10.0IL8
27allergic rhinitis10.0IL8
28bronchiolitis10.0IL8
29rhinitis10.0IL8
30pulmonary fibrosis10.0IL8
31thrombocytopenia10.0IL6
32malaria10.0TNF
33poems syndrome10.0IL6
34skin disease10.0IL6
35tuberculosis10.0TNF
36periodontitis10.0IL8
37pulmonary disease, chronic obstructive10.0IL6
38cystic fibrosis10.0SLC26A3, IL8
39coronary heart disease10.0IL6
40adult respiratory distress syndrome10.0TNF, IL8
41alcoholic hepatitis10.0TNF, IL8
42respiratory failure10.0TNF, IL6
43kaposi's sarcoma10.0IL6
44behcet's disease10.0TNF, IL8
45hypersensitivity reaction type ii disease10.0IL6, TNF
46periodontal disease10.0IL6, TNF
47viral meningitis10.0IL8, IL6
48inflammatory bowel disease10.0IL8, IL6
49acute pancreatitis10.0IL6, IL8
50juvenile rheumatoid arthritis10.0TNF, IL6

Graphical network of the top 20 diseases related to Spermatocele:



Diseases related to spermatocele

Clinical Features for Spermatocele

Drugs & Therapeutics for Spermatocele

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spermatocele

Drug clinical trials:

Search ClinicalTrials for Spermatocele

Search NIH Clinical Center for Spermatocele

Search CenterWatch for Spermatocele

Genetic Tests for Spermatocele

Anatomical Context for Spermatocele

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Spermatocele:

33
Kidney, Prostate, Testis

Animal Models for Spermatocele or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Spermatocele:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1SLC26A3, IL6, DDX4, TNF

Publications for Spermatocele

Sources:
51PubMed
See all sources

Articles related to Spermatocele:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Spermatocele following kidney transplant. (22487000)
2012
2
Adult hydrocele and spermatocele. (21592287)
2011
3
A randomized trial comparing 2 doses of polidocanol sclerotherapy for hydrocele or spermatocele. (21849198)
2011
4
Small blue cells mimicking small cell carcinoma in spermatocele and hydrocele specimens: a report of 5 cases. (19740515)
2010
5
Male fertility after spermatocele formation from tunica vaginalis in patients with bilateral vas agenesis. (18580017)
2008
6
Spermatocele presenting as acute scrotum. (18825632)
2008
7
Bilateral spermatocele concurrent with bilateral scrotal hydrocele presenting huge scrotal swelling. (18018592)
2007
8
Giant spermatocele mimicking hydrocele: a case report. (17606432)
2007
9
Theriogenology question of the month. Seminoma, spermatocele, sustentacular cell tumor. (15906562)
2005
10
What causes a spermatocele, and how is it usually removed? (15132122)
2004
11
Spermatocele: a rare complication of rectal surgery and radiotherapy. Case report. (15154581)
2004
12
Primary bilateral spermatocele. (12534930)
2003
13
Retrieval and cryopreservation of sperm from spermatocele fluid. (12597959)
2003
14
Torsion of spermatocele: a rare manifestation. (12187053)
2002
15
Pro-inflammatory cytokine response of the fluid contents of spermatoceles and epididymal cysts. (11966578)
2002
16
Multilocular spermatocele: a case report. (11583363)
2001
17
Spermatocele in a common noctule (Nyctalus noctula). (10638800)
1999
18
Percutaneous sperm aspiration of a spermatocele for intracytoplasmic sperm injection. (9302159)
1997
19
Torsion of spermatocele and aplasia of the vas deferens. A case report. (9165262)
1997
20
Development of a new alloplastic spermatocele demonstrating successful sperm retrieval in an animal model. (7789555)
1995
21
Torsion of a spermatocele. (7500478)
1995
22
Effect of spermatocele fluid on growth of human prostatic cells in culture. (8226302)
1993
23
Congenital absence of vas deferens treated by artificial spermatocele constructed from the tunica vaginalis; report of six cases. (8272538)
1993
24
Clinical experience and successful impregnation using an artificial spermatocele. (1771703)
1991
25
Artificial spermatocele persisting for 14 years. (2398578)
1990
26
In vitro fertilization with spermatozoa from alloplastic spermatocele. (2318332)
1990
27
Fertilization of human oocytes by spermatozoa from an artificial spermatocele. (3788432)
1986
28
Alloplastic spermatocele. (3735514)
1986
29
Implantation of artificial spermatocele with cup-shaped prosthesis for excretory azoospermia and chemical management of aspirated spermatozoa. (3745009)
1986
30
Properties of human epididymal sperm obtained from an alloplastic spermatocele: motility assessment and penetration of zona-free hamster oocytes in the presence and absence of caffeine. (4029429)
1985
31
Alloplastic spermatocele in cases of vasa aplasia. (4051632)
1985
32
A new type of alloplastic spermatocele: the bridge spermatocele. (6708803)
1984
33
Alloplastic spermatocele: diffusion across the allograft material and survival of spermatozoa in vitro and in vivo. (6471203)
1984
34
Clinical experience with an artificial spermatocele. (6469865)
1984
35
Artificial spermatocele inserted onto the vas deferens: a clinical report. (6367333)
1983
36
Outpatient hydrocele and spermatocele repair under local anesthesia. (6348308)
1983
37
KelAcmi-Affeld alloplastic spermatocele and successful human delivery. (7324302)
1981
38
New development in surgical andrology. Alloplastic spermatocele. (6445342)
1980
39
Artificial spermatocele. (7382006)
1980
40
Microsurgery in andrologic urology. II. Alloplastic spermatocele. (6450257)
1980
41
Clinical experience with an alloplastic spermatocele. (736276)
1978
42
New device for the treatment of certain cases of male infertility--alloplastic spermatocele. (910357)
1977
43
Further experiences with an alloplastic spermatocele: experiements in bulbs. (142431)
1977
44
Alloplastic spermatocele: epididymal reservoir using artificial material. (617915)
1977
45
Modern trends of surgical treatment in male infertility: alloplastic spermatocele in cases of excretory azoospermia. (134896)
1976
46
The protein content of spermatocele fluid. (4109471)
1971
47
Immunological and chemical studies of spermatocele fluid. (13783824)
1961
48
Immunological differentiation of human testicular (spermatocele) and seminal spermatozoa. (13783825)
1960
49
Spermatocele. (13295740)
1956
50
SPERMATOCELE. (17864356)
1920

Genetic Variations for Spermatocele

Expression for genes affiliated with Spermatocele

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spermatocele

Search GEO for disease gene expression data for Spermatocele.

Pathways for genes affiliated with Spermatocele

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems, 52QIAGEN, 54Reactome
See all sources

Pathways related to Spermatocele according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL8
210.0IL8
39.3IL6, IL8
49.3IL8, IL6
59.3IL8, IL6
6
Cytokine production by Th17 cells in CF (Mouse model)
9.3IL6, IL8
79.3IL6, IL8
89.3IL8, IL6
9
Hide members
9.1IL8, TNF
109.1TNF, IL8
119.0IL6, TNF
12
Hide members
9.0TNF, IL6
139.0TNF, IL6
149.0TNF, IL6
159.0TNF, IL6
169.0IL6, TNF
17
Hide members
8.5TNF, IL8, IL6
18
Hide members
8.5TNF, IL6, IL8
198.5TNF, IL8, IL6
208.5TNF, IL8, IL6
21
Immune response Bacterial infections in normal airways
8.5TNF, IL6, IL8
228.5TNF, IL8, IL6
23
Hide members
8.5TNF, IL6, IL8
248.5IL8, TNF, IL6
25
Hide members
8.5TNF, IL8, IL6
268.5IL6, TNF, IL8
27
Hide members
8.5TNF, IL8, IL6
28
Hide members
8.5TNF, IL8, IL6

Compounds for genes affiliated with Spermatocele

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Spermatocele according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1troglitazone45 29 60 1113.3IL8
2gm-csf45 2911.1TNF
3emedastine45 1110.7IL8, IL6
4tepoxalin459.7IL8, IL6
5sivelestat459.7IL8, IL6
6rebamipide459.7IL8, IL6
7olopatadine45 1110.6IL6, IL8
8mcp 1459.5IL8, IL6
9hbd2459.5IL6, IL8
10u0126459.4IL8, IL6
11cilomilast459.4TNF, IL8
12tocilizumab45 1110.4IL6, TNF
13n-tosyl-l-phenylalanine chloromethyl ketone459.4IL8, TNF
14abatacept45 1110.4IL6, TNF
15cdp571459.4IL6, TNF
16toxin-1459.3IL8, TNF
17anakinra45 1110.3IL6, TNF
18vesnarinone459.3IL6, TNF
19hcec459.2IL8, IL6
20gold sodium thiomalate459.2IL8, TNF
21aebsf459.1IL8, TNF
22taurine chloramine459.0TNF, IL8, IL6
23mip 1alpha459.0TNF, IL6, IL8
24il-12459.0IL8, IL6, TNF
25tpck459.0TNF, IL8, IL6
26imiquimod45 29 60 1112.0TNF, IL6, IL8
27polymyxin b459.0TNF, IL8, IL6
28groalpha458.9IL6, IL8, TNF
29triptolide458.9IL6, IL8, TNF
30parthenolide45 29.9TNF, IL6, IL8
31ciglitazone45 299.9IL6, IL8, TNF
32lipoteichoic acid458.9IL6, IL8, TNF
338-isoprostane458.9IL6, IL8, TNF
34polyinosinic-polycytidylic acid458.9TNF, IL8, IL6
35etanercept45 50 1110.9IL6, TNF, IL8
36poly(i-c)458.9TNF, IL6, IL8
37il 10458.9IL6, IL8, TNF
38peptidoglycan45 299.9IL6, TNF, IL8
39ccl345 299.9IL6, IL8, TNF
40neopterin458.9TNF, IL6, IL8
4115-deoxy-delta-12,14-prostaglandin j2458.9IL6, IL8, TNF
42pdtc458.9TNF, IL8, IL6
43leukotriene b445 60 2410.9TNF, IL6, IL8
44sp 60012545 609.9IL6, IL8, TNF
45hydrocortisone45 2 60 1111.8IL6, IL8, TNF
46simvastatin45 50 60 29 11 2413.8IL8, IL6, TNF
47herbimycin a45 609.8IL6, TNF, IL8
48curcumin458.8IL6, IL8, TNF
49adalimumab45 50 1110.7TNF, IL6
50rantes458.5IL8, IL6, TNF

GO Terms for genes affiliated with Spermatocele

Sources:
16Gene Ontology
See all sources

Biological processes related to Spermatocele according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.4TNF, IL8
2epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.3TNF, IL6
3negative regulation of lipid storageGO:0108889.3TNF, IL6
4positive regulation of chemokine productionGO:0327229.3TNF, IL6
5positive regulation of nitric oxide biosynthetic processGO:0454299.3TNF, IL6
6negative regulation of fat cell differentiationGO:0455999.3IL6, TNF
7defense response to Gram-positive bacteriumGO:0508309.3TNF, IL6
8positive regulation of interleukin-6 productionGO:0327559.2TNF, IL6
9calcium-mediated signalingGO:0197229.2TNF, IL8
10positive regulation of smooth muscle cell proliferationGO:0486619.2IL6, TNF
11humoral immune responseGO:0069599.1IL6, TNF
12response to mechanical stimulusGO:0096129.0TNF, IL6
13positive regulation of protein kinase B signaling cascadeGO:0518979.0IL6, TNF
14positive regulation of peptidyl-serine phosphorylationGO:0331388.9TNF, IL6
15inflammatory responseGO:0069548.8IL6, IL8, TNF
16response to glucocorticoid stimulusGO:0513848.7IL6, TNF
17negative regulation of cell proliferationGO:0082858.7IL6, IL8, TNF

Products for genes affiliated with Spermatocele

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spermatocele

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet