MCID: SPR017
MIFTS: 42

Spermatocele malady

Reproductive diseases category

Summaries for Spermatocele

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63Wikipedia, 32MalaCards
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Wikipedia:63 Spermatocele (/spɜrˈmætəsiːl/) is a retention cyst of a tubule of the rete testis or the head of... more...

MalaCards: Spermatocele is related to infertility and hydrocele. An important gene associated with Spermatocele is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are ATF-2 transcription factor network and Legionellosis. The compounds troglitazone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include testis, prostate and kidney, and related mouse phenotype endocrine/exocrine gland.

Aliases & Classifications for Spermatocele

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

spermatocele 8 44 60


External Ids:

Disease Ontology8 DOID:11997
ICD9CM27 608.1
NCIt39 C3865
MeSH34 D013088
ICD1025 N43.4

Related Diseases for Spermatocele

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Spermatocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.1DDX4
2hydrocele10.4
3azoospermia10.1
4male infertility10.1
5prostatitis10.1
6diarrhea10.0SLC26A3
7arthropathy10.0TNF
8toxic shock syndrome10.0TNF
9familial mediterranean fever10.0TNF
10interstitial lung disease10.0TNF
11psoriatic arthritis10.0TNF
12uveitis10.0TNF
13diastrophic dysplasia10.0SLC26A3
14adenoma10.0SLC26A3
15bacterial vaginosis10.0IL8
16vasculitis10.0TNF
17bronchiolitis obliterans10.0IL8
18mastitis10.0IL8
19duodenal ulcer10.0IL8
20bronchiectasis10.0IL8
21peptic ulcer10.0IL8
22bronchopulmonary dysplasia10.0IL8
23proliferative diabetic retinopathy10.0IL8
24sarcoidosis10.0TNF
25common cold10.0IL8
26gastritis10.0IL8
27allergic rhinitis10.0IL8
28bronchiolitis10.0IL8
29rhinitis10.0IL8
30pulmonary fibrosis10.0IL8
31thrombocytopenia10.0IL6
32malaria10.0TNF
33poems syndrome10.0IL6
34skin disease10.0IL6
35tuberculosis10.0TNF
36periodontitis10.0IL8
37pulmonary disease, chronic obstructive10.0IL6
38cystic fibrosis10.0SLC26A3, IL8
39coronary heart disease10.0IL6
40adult respiratory distress syndrome10.0IL8, TNF
41alcoholic hepatitis10.0IL8, TNF
42respiratory failure10.0TNF, IL6
43behcet's disease10.0TNF, IL8
44hypersensitivity reaction type ii disease10.0IL6, TNF
45periodontal disease10.0IL6, TNF
46viral meningitis10.0IL6, IL8
47inflammatory bowel disease10.0IL6, IL8
48acute pancreatitis10.0IL8, IL6
49juvenile rheumatoid arthritis10.0IL6, TNF
50kaposi's sarcoma10.0IL6

Graphical network of the top 20 diseases related to Spermatocele:



Diseases related to spermatocele

Clinical Features for Spermatocele

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Drugs & Therapeutics for Spermatocele

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spermatocele

Drug clinical trials:

Search ClinicalTrials for Spermatocele

Search NIH Clinical Center for Spermatocele

Search CenterWatch for Spermatocele

Genetic Tests for Spermatocele

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Anatomical Context for Spermatocele

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32MalaCards
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MalaCards organs/tissues related to Spermatocele:

32
Testis, Prostate, Kidney

Animal Models for Spermatocele or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Spermatocele:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1SLC26A3, IL6, DDX4, TNF

Publications for Spermatocele

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Sources:
50PubMed
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Articles related to Spermatocele:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Presence of benign germ cells in a fine needle aspirate of a spermatocele. (22045691)
2013
2
Spermatocele following kidney transplant. (22487000)
2012
3
Adult hydrocele and spermatocele. (21592287)
2011
4
A randomized trial comparing 2 doses of polidocanol sclerotherapy for hydrocele or spermatocele. (21849198)
2011
5
Spermiophages in a giant spermatocele. (19941373)
2010
6
Small blue cells mimicking small cell carcinoma in spermatocele and hydrocele specimens: a report of 5 cases. (19740515)
2010
7
Male fertility after spermatocele formation from tunica vaginalis in patients with bilateral vas agenesis. (18580017)
2008
8
Spermatocele presenting as acute scrotum. (18825632)
2008
9
Bilateral spermatocele concurrent with bilateral scrotal hydrocele presenting huge scrotal swelling. (18018592)
2007
10
Giant spermatocele mimicking hydrocele: a case report. (17606432)
2007
11
Theriogenology question of the month. Seminoma, spermatocele, sustentacular cell tumor. (15906562)
2005
12
What causes a spermatocele, and how is it usually removed? (15132122)
2004
13
Spermatocele: a rare complication of rectal surgery and radiotherapy. Case report. (15154581)
2004
14
Primary bilateral spermatocele. (12534930)
2003
15
Retrieval and cryopreservation of sperm from spermatocele fluid. (12597959)
2003
16
Torsion of spermatocele: a rare manifestation. (12187053)
2002
17
Pro-inflammatory cytokine response of the fluid contents of spermatoceles and epididymal cysts. (11966578)
2002
18
Multilocular spermatocele: a case report. (11583363)
2001
19
Spermatocele in a common noctule (Nyctalus noctula). (10638800)
1999
20
Percutaneous sperm aspiration of a spermatocele for intracytoplasmic sperm injection. (9302159)
1997
21
Development of a new alloplastic spermatocele demonstrating successful sperm retrieval in an animal model. (7789555)
1995
22
Torsion of a spermatocele. (7500478)
1995
23
Effect of spermatocele fluid on growth of human prostatic cells in culture. (8226302)
1993
24
Congenital absence of vas deferens treated by artificial spermatocele constructed from the tunica vaginalis; report of six cases. (8272538)
1993
25
Clinical experience and successful impregnation using an artificial spermatocele. (1771703)
1991
26
Artificial spermatocele persisting for 14 years. (2398578)
1990
27
In vitro fertilization with spermatozoa from alloplastic spermatocele. (2318332)
1990
28
Fertilization of human oocytes by spermatozoa from an artificial spermatocele. (3788432)
1986
29
Alloplastic spermatocele. (3735514)
1986
30
Alloplastic spermatocele: poor sperm motility in intraoperative epididymal fluid contraindicates prosthesis implantation. (3735504)
1986
31
Implantation of artificial spermatocele with cup-shaped prosthesis for excretory azoospermia and chemical management of aspirated spermatozoa. (3745009)
1986
32
Properties of human epididymal sperm obtained from an alloplastic spermatocele: motility assessment and penetration of zona-free hamster oocytes in the presence and absence of caffeine. (4029429)
1985
33
Alloplastic spermatocele in cases of vasa aplasia. (4051632)
1985
34
Alloplastic spermatocele: diffusion across the allograft material and survival of spermatozoa in vitro and in vivo. (6471203)
1984
35
Clinical experience with an artificial spermatocele. (6469865)
1984
36
Artificial spermatocele inserted onto the vas deferens: a clinical report. (6367333)
1983
37
Outpatient hydrocele and spermatocele repair under local anesthesia. (6348308)
1983
38
KelAcmi-Affeld alloplastic spermatocele and successful human delivery. (7324302)
1981
39
New development in surgical andrology. Alloplastic spermatocele. (6445342)
1980
40
Artificial spermatocele. (7382006)
1980
41
Microsurgery in andrologic urology. II. Alloplastic spermatocele. (6450257)
1980
42
Clinical experience with an alloplastic spermatocele. (736276)
1978
43
Further experiences with an alloplastic spermatocele: experiements in bulbs. (142431)
1977
44
Modern trends of surgical treatment in male infertility: alloplastic spermatocele in cases of excretory azoospermia. (134896)
1976
45
The protein content of spermatocele fluid. (4109471)
1971
46
Atypical cells in spermatocele fluid. (5283472)
1971
47
Immunological and chemical studies of spermatocele fluid. (13783824)
1961
48
Immunological differentiation of human testicular (spermatocele) and seminal spermatozoa. (13783825)
1960
49
Spermatocele. (13295740)
1956
50
SPERMATOCELE. (17864356)
1920

Genetic Variations for Spermatocele

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Expression for genes affiliated with Spermatocele

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spermatocele

Search GEO for disease gene expression data for Spermatocele.

Pathways for genes affiliated with Spermatocele

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN, 52R&D Systems, 53Reactome
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Pathways related to Spermatocele according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL8
210.0IL8
39.3IL8, IL6
49.3IL6, IL8
59.3IL8, IL6
6
Cytokine production by Th17 cells in CF (Mouse model)
9.3IL8, IL6
79.3IL6, IL8
89.3IL6, IL8
9
Hide members
9.1TNF, IL8
109.1TNF, IL8
119.0TNF, IL6
12
Hide members
9.0IL6, TNF
139.0TNF, IL6
149.0TNF, IL6
159.0IL6, TNF
169.0IL6, TNF
17
Hide members
8.5TNF, IL8, IL6
18
Hide members
8.5IL6, IL8, TNF
198.5IL6, IL8, TNF
208.5IL6, IL8, TNF
21
Immune response Bacterial infections in normal airways
8.5TNF, IL8, IL6
228.5IL6, IL8, TNF
23
Hide members
8.5IL6, IL8, TNF
248.5IL6, IL8, TNF
25
Hide members
8.5IL6, IL8, TNF
268.5IL6, IL8, TNF
27
Hide members
8.5TNF, IL8, IL6
28
Hide members
8.5IL6, IL8, TNF

Compounds for genes affiliated with Spermatocele

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Spermatocele according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1troglitazone44 28 59 1113.3IL8
2gm-csf44 2811.1TNF
3emedastine44 1110.7IL8, IL6
4tepoxalin449.7IL8, IL6
5sivelestat449.7IL8, IL6
6rebamipide449.7IL8, IL6
7olopatadine44 1110.6IL6, IL8
8mcp 1449.5IL8, IL6
9hbd2449.5IL6, IL8
10u0126449.4IL8, IL6
11cilomilast449.4TNF, IL8
12tocilizumab44 1110.4IL6, TNF
13n-tosyl-l-phenylalanine chloromethyl ketone449.4IL8, TNF
14abatacept44 1110.4IL6, TNF
15cdp571449.4IL6, TNF
16toxin-1449.3IL8, TNF
17anakinra44 1110.3IL6, TNF
18vesnarinone449.3IL6, TNF
19hcec449.2IL8, IL6
20gold sodium thiomalate449.2IL8, TNF
21aebsf449.1IL8, TNF
22taurine chloramine449.0TNF, IL8, IL6
23mip 1alpha449.0TNF, IL6, IL8
24il-12449.0IL8, IL6, TNF
25tpck449.0TNF, IL8, IL6
26imiquimod44 28 59 1112.0TNF, IL6, IL8
27polymyxin b449.0TNF, IL8, IL6
28groalpha448.9IL6, IL8, TNF
29triptolide448.9IL6, IL8, TNF
30parthenolide44 29.9TNF, IL6, IL8
31ciglitazone44 289.9IL6, IL8, TNF
32lipoteichoic acid448.9IL6, IL8, TNF
338-isoprostane448.9IL6, IL8, TNF
34polyinosinic-polycytidylic acid448.9TNF, IL8, IL6
35etanercept44 49 1110.9IL6, TNF, IL8
36poly(i-c)448.9TNF, IL6, IL8
37il 10448.9IL6, IL8, TNF
38peptidoglycan44 289.9IL6, TNF, IL8
39ccl344 289.9IL6, IL8, TNF
40neopterin448.9TNF, IL6, IL8
4115-deoxy-delta-12,14-prostaglandin j2448.9IL6, IL8, TNF
42pdtc448.9TNF, IL8, IL6
43leukotriene b444 59 2410.9TNF, IL6, IL8
44sp 60012544 599.9IL6, IL8, TNF
45hydrocortisone44 2 59 1111.8IL6, IL8, TNF
46simvastatin44 49 59 28 11 2413.8IL8, IL6, TNF
47herbimycin a44 599.8IL6, TNF, IL8
48curcumin448.8IL6, IL8, TNF
49adalimumab44 49 1110.7TNF, IL6
50rantes448.5IL8, IL6, TNF

GO Terms for genes affiliated with Spermatocele

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16Gene Ontology
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Biological processes related to Spermatocele according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.4IL8, TNF
2negative regulation of lipid storageGO:0108889.3IL6, TNF
3epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.3IL6, TNF
4positive regulation of chemokine productionGO:0327229.3IL6, TNF
5positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, TNF
6negative regulation of fat cell differentiationGO:0455999.3IL6, TNF
7defense response to Gram-positive bacteriumGO:0508309.3IL6, TNF
8positive regulation of interleukin-6 productionGO:0327559.2TNF, IL6
9calcium-mediated signalingGO:0197229.2TNF, IL8
10positive regulation of smooth muscle cell proliferationGO:0486619.2IL6, TNF
11humoral immune responseGO:0069599.1IL6, TNF
12response to mechanical stimulusGO:0096129.0IL6, TNF
13positive regulation of protein kinase B signaling cascadeGO:0518979.0IL6, TNF
14positive regulation of peptidyl-serine phosphorylationGO:0331388.9IL6, TNF
15inflammatory responseGO:0069548.8TNF, IL8, IL6
16response to glucocorticoid stimulusGO:0513848.7IL6, TNF
17negative regulation of cell proliferationGO:0082858.7IL6, IL8, TNF

Products for genes affiliated with Spermatocele

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spermatocele

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet