MCID: SPR017
MIFTS: 42

Spermatocele malady

Reproductive diseases category

Summaries for Spermatocele

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66Wikipedia, 34MalaCards
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MalaCards: Spermatocele is related to hydrocele and epididymitis. An important gene associated with Spermatocele is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The compounds rantes and cilomilast have been mentioned in the context of this disorder. Affiliated tissues include prostate and kidney, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Spermatocele

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9Disease Ontology, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

spermatocele 9 46 63


External Ids:

Disease Ontology9 DOID:11997
ICD9CM28 608.1
NCIt41 C3865
MeSH36 D013088
ICD1026 N43.4

Related Diseases for Spermatocele

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Spermatocele via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1hydrocele10.5
2epididymitis10.4
3infertility10.2
4azoospermia10.2
5male infertility10.2
6prostatitis10.2
7crohn's disease10.1TNF
8adult respiratory distress syndrome10.0IL8, TNF
9alcoholic hepatitis10.0TNF, IL8
10behcet's disease10.0TNF, IL8
11juvenile rheumatoid arthritis10.0IL6, TNF
12respiratory failure10.0IL6, TNF
13infected hydrocele10.0
14small cell carcinoma10.0
15von hippel-lindau disease10.0
16seminoma10.0
17maturity-onset diabetes of the young, type 510.0
18periodontal disease10.0TNF, IL6
19viral meningitis10.0IL8, IL6
20peritonitis10.0IL6, TNF
21connective tissue disease10.0TNF, IL6
22newborn respiratory distress syndrome10.0IL6, IL8
23meningitis10.0IL6, IL8
24skin disease10.0IL8, TNF
25hypersensitivity reaction type ii disease10.0IL6, TNF
26galactosemia10.0IL6, TNF
27acute pancreatitis10.0IL6, IL8
28primary hyperoxaluria10.0TNF, IL6
29inflammatory bowel disease10.0IL6, IL8
30atopic dermatitis10.0IL8, TNF
31congenital heart disease10.0IL6, TNF
32endometriosis10.0IL8, IL6
33cork-handlers' disease10.0IL8, TNF
34chorioamnionitis10.0IL6, IL8, TNF
35periodontitis9.9IL6, IL8, TNF
36synovitis9.9IL6, IL8, TNF
37monocytic leukemia9.9TNF, IL8, IL6
38septic shock9.9IL6, IL8, TNF
39pulmonary disease, chronic obstructive9.9TNF, IL8, IL6
40pneumonia9.9IL6, IL8, TNF
41vascular disease9.9IL6, IL8, TNF
42ulcerative colitis9.9IL6, IL8, TNF
43sepsis9.9TNF, IL8, IL6
44osteoarthritis9.9TNF, IL8, IL6
45psoriasis9.9IL6, IL8, TNF
46arthritis9.9IL6, IL8, TNF
47viral infectious disease9.9IL6, IL8, TNF
48atherosclerosis9.9TNF, IL8, IL6
49rheumatoid arthritis9.9IL6, IL8, TNF

Graphical network of the top 20 diseases related to Spermatocele:



Diseases related to spermatocele

Symptoms for Spermatocele

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Drugs & Therapeutics for Spermatocele

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Spermatocele

Drug clinical trials:

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Search CenterWatch for Spermatocele

Genetic Tests for Spermatocele

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Anatomical Context for Spermatocele

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34MalaCards
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MalaCards organs/tissues related to Spermatocele:

34
Prostate, Kidney

Animal Models for Spermatocele or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Spermatocele:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6SLC26A3, IL6, TNF

Publications for Spermatocele

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Sources:
53PubMed
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Articles related to Spermatocele:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Spermatocele following kidney transplant. (22487000)
2012
2
Extra scrotal spermatocele causing lower abdominal pain: a first case report. (20674226)
2011
3
Adult hydrocele and spermatocele. (21592287)
2011
4
A randomized trial comparing 2 doses of polidocanol sclerotherapy for hydrocele or spermatocele. (21849198)
2011
5
Spermiophages in a giant spermatocele. (19941373)
2010
6
Male fertility after spermatocele formation from tunica vaginalis in patients with bilateral vas agenesis. (18580017)
2008
7
Spermatocele presenting as acute scrotum. (18825632)
2008
8
Bilateral spermatocele concurrent with bilateral scrotal hydrocele presenting huge scrotal swelling. (18018592)
2007
9
What causes a spermatocele, and how is it usually removed? (15132122)
2004
10
Spermatocele: a rare complication of rectal surgery and radiotherapy. Case report. (15154581)
2004
11
Primary bilateral spermatocele. (12534930)
2003
12
Retrieval and cryopreservation of sperm from spermatocele fluid. (12597959)
2003
13
Torsion of spermatocele: a rare manifestation. (12187053)
2002
14
Pro-inflammatory cytokine response of the fluid contents of spermatoceles and epididymal cysts. (11966578)
2002
15
Multilocular spermatocele: a case report. (11583363)
2001
16
Spermatocele in a common noctule (Nyctalus noctula). (10638800)
1999
17
Intratesticular spermatocele. (9610575)
1998
18
Synergistic action of steroids and spermatocele fluid on in vitro proliferation of prostate stroma. (9598570)
1998
19
Percutaneous sperm aspiration of a spermatocele for intracytoplasmic sperm injection. (9302159)
1997
20
Torsion of spermatocele and aplasia of the vas deferens. A case report. (9165262)
1997
21
Development of a new alloplastic spermatocele demonstrating successful sperm retrieval in an animal model. (7789555)
1995
22
Torsion of a spermatocele. (7500478)
1995
23
Alloplastic spermatocele: 20 years experience and perspectives. (7618373)
1994
24
Effect of spermatocele fluid on growth of human prostatic cells in culture. (8226302)
1993
25
Clinical experience and successful impregnation using an artificial spermatocele. (1771703)
1991
26
Artificial spermatocele persisting for 14 years. (2398578)
1990
27
In vitro fertilization with spermatozoa from alloplastic spermatocele. (2318332)
1990
28
Fertilization of human oocytes by spermatozoa from an artificial spermatocele. (3788432)
1986
29
Alloplastic spermatocele. (3735514)
1986
30
Alloplastic spermatocele: poor sperm motility in intraoperative epididymal fluid contraindicates prosthesis implantation. (3735504)
1986
31
Implantation of artificial spermatocele with cup-shaped prosthesis for excretory azoospermia and chemical management of aspirated spermatozoa. (3745009)
1986
32
Properties of human epididymal sperm obtained from an alloplastic spermatocele: motility assessment and penetration of zona-free hamster oocytes in the presence and absence of caffeine. (4029429)
1985
33
Torsion of spermatocele: a newly described entity with 2 case reports. (3981724)
1985
34
A new type of alloplastic spermatocele: the bridge spermatocele. (6708803)
1984
35
Alloplastic spermatocele: diffusion across the allograft material and survival of spermatozoa in vitro and in vivo. (6471203)
1984
36
New development in surgical andrology. Alloplastic spermatocele. (6445342)
1980
37
Artificial spermatocele. (7382006)
1980
38
Microsurgery in andrologic urology. II. Alloplastic spermatocele. (6450257)
1980
39
Clinical experience with an alloplastic spermatocele. (736276)
1978
40
New device for the treatment of certain cases of male infertility--alloplastic spermatocele. (910357)
1977
41
Further experiences with an alloplastic spermatocele: experiements in bulbs. (142431)
1977
42
Alloplastic spermatocele: epididymal reservoir using artificial material. (617915)
1977
43
Alloplastic spermatocele: insemination from epididymal reservoir. (562549)
1977
44
Modern trends of surgical treatment in male infertility: alloplastic spermatocele in cases of excretory azoospermia. (134896)
1976
45
The protein content of spermatocele fluid. (4109471)
1971
46
Atypical cells in spermatocele fluid. (5283472)
1971
47
Spermatocele: pathologic and surgical anatomy. (14021557)
1963
48
Immunological and chemical studies of spermatocele fluid. (13783824)
1961
49
Spermatocele. (13295740)
1956
50
TREATMENT OF HYDROCELE AND SPERMATOCELE. (20782045)
1939

Variations for Spermatocele

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Expression for genes affiliated with Spermatocele

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spermatocele

Search GEO for disease gene expression data for Spermatocele.

Pathways for genes affiliated with Spermatocele

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN, 55R&D Systems, 61Thomson Reuters, 13EMD Millipore
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Pathways related to Spermatocele according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.3TNF, IL8
2
Show member pathways
9.3IL8, TNF
39.3IL8, TNF
49.3IL8, TNF
59.3IL8, TNF
69.1TNF, IL6
79.1IL6, TNF
8
Show member pathways
thioredoxin pathway39
9.1TNF, IL6
99.1TNF, IL6
109.1TNF, IL6
11
Show member pathways
IL27-mediated signaling events39
9.1TNF, IL6
129.1IL6, TNF
13
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.1TNF, IL6
14
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.1IL6, TNF
159.1TNF, IL6
169.1IL6, TNF
17
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.1IL6, TNF
189.1TNF, IL6
19
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1IL6, TNF
209.1IL6, TNF
21
Show member pathways
9.0IL6, IL8
229.0IL6, IL8
239.0IL6, IL8
249.0IL8, IL6
259.0IL6, IL8
269.0IL8, IL6
279.0IL8, IL6
28
Show member pathways
9.0IL6, IL8
299.0IL6, IL8
308.5TNF, IL8, IL6
31
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.5TNF, IL8, IL6
328.5TNF, IL8, IL6
33
Show member pathways
8.5TNF, IL8, IL6
34
Show member pathways
Immune response MIF in innate immunity response61
8.5TNF, IL8, IL6
35
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.5TNF, IL8, IL6
36
Show member pathways
8.5TNF, IL8, IL6
37
Show member pathways
8.5TNF, IL8, IL6
38
Show member pathways
8.5TNF, IL8, IL6
39
Show member pathways
8.5TNF, IL8, IL6
40
Show member pathways
8.5IL6, IL8, TNF
418.5IL6, IL8, TNF
428.5IL6, IL8, TNF
438.5IL6, IL8, TNF
448.5IL6, IL8, TNF
458.5IL6, IL8, TNF
46
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5IL6, IL8, TNF
478.5IL6, IL8, TNF
488.5IL6, IL8, TNF
49
Show member pathways
8.5IL6, IL8, TNF
50
Show member pathways
8.5IL6, IL8, TNF

Compounds for genes affiliated with Spermatocele

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB, 52PharmGKB, 25HMDB
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Compounds related to Spermatocele according to GeneCards/GeneDecks:

(show top 50)    (show all 104)
idCompoundScoreTop Affiliating Genes
1rantes469.9IL8
2cilomilast469.6TNF, IL8
3n-tosyl-l-phenylalanine chloromethyl ketone469.5IL8, TNF
4tocilizumab46 1210.5IL6, TNF
5abatacept46 1210.5IL6, TNF
6cdp571469.4IL6, TNF
7emedastine46 1210.4IL8, IL6
8tepoxalin469.4IL6, IL8
9sivelestat469.4IL6, IL8
10tenidap46 3010.3TNF, IL6
11rebamipide469.3IL8, IL6
12anakinra46 1210.3IL6, TNF
13vesnarinone469.2TNF, IL6
14toxin-1469.2IL8, TNF
15olopatadine46 1210.1IL8, IL6
16mcp 1469.0IL6, IL8
17taurine chloramine469.0IL6, IL8, TNF
18gabexate mesilate469.0TNF, IL8, IL6
19ulinastatin469.0IL6, IL8, TNF
20mip 1alpha469.0TNF, IL8, IL6
21il-12469.0IL6, IL8, TNF
22imiquimod46 62 30 1211.9TNF, IL8, IL6
23tpck468.9TNF, IL8, IL6
24polymyxin b468.9IL6, IL8, TNF
25groalpha468.9TNF, IL8, IL6
26gm-csf46 309.9TNF, IL8, IL6
27triptolide468.9TNF, IL8, IL6
28parthenolide46 39.9TNF, IL8, IL6
29ciglitazone46 309.9TNF, IL8, IL6
30lipoteichoic acid468.9IL6, IL8, TNF
318-isoprostane468.9TNF, IL8, IL6
32polyinosinic-polycytidylic acid468.9IL6, IL8, TNF
33etanercept46 52 1210.9IL6, IL8, TNF
34poly(i-c)468.9TNF, IL8, IL6
35il 10468.9IL6, IL8, TNF
36peptidoglycan46 309.9TNF, IL8, IL6
37ccl346 309.9TNF, IL8, IL6
38pentoxifylline46 129.9TNF, IL8, IL6
39neopterin468.9TNF, IL8, IL6
4015-deoxy-delta-12,14-prostaglandin j2468.9IL6, IL8, TNF
41pdtc468.9IL6, IL8, TNF
42leukotriene b446 62 2510.9IL6, IL8, TNF
43sp 60012546 629.9TNF, IL8, IL6
44hydrocortisone46 3 62 1211.8TNF, IL8, IL6
45troglitazone46 30 62 1211.8IL6, IL8, TNF
46herbimycin a46 629.8IL6, IL8, TNF
47simvastatin46 52 62 30 25 1213.8IL6, IL8, TNF
48endotoxin468.8TNF, IL8, IL6
49curcumin468.7IL6, IL8, TNF
50hbd2468.7IL6, IL8

GO Terms for genes affiliated with Spermatocele

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Sources:
17Gene Ontology
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Cellular components related to Spermatocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1IL6, TNF
2extracellular spaceGO:0056158.2IL6, IL8, TNF

Biological processes related to Spermatocele according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1embryonic digestive tract developmentGO:0485669.6IL8, TNF
2calcium-mediated signalingGO:0197229.6IL8, TNF
3negative regulation of lipid storageGO:0108889.5IL6, TNF
4epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5IL6, TNF
5positive regulation of chemokine productionGO:0327229.5IL6, TNF
6positive regulation of nitric oxide biosynthetic processGO:0454299.4TNF, IL6
7defense response to Gram-positive bacteriumGO:0508309.4IL6, TNF
8negative regulation of fat cell differentiationGO:0455999.4IL6, TNF
9positive regulation of interleukin-6 productionGO:0327559.4TNF, IL6
10positive regulation of smooth muscle cell proliferationGO:0486619.3IL6, TNF
11positive regulation of peptidyl-serine phosphorylationGO:0331389.3TNF, IL6
12response to mechanical stimulusGO:0096129.3IL6, TNF
13humoral immune responseGO:0069599.2TNF, IL6
14positive regulation of protein kinase B signalingGO:0518979.2IL6, TNF
15response to glucocorticoidGO:0513849.1IL6, TNF
16positive regulation of NF-kappaB transcription factor activityGO:0510929.1IL6, TNF
17positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.0TNF, IL6
18positive regulation of ERK1 and ERK2 cascadeGO:0703748.8IL6, TNF
19inflammatory responseGO:0069548.8TNF, IL8, IL6
20negative regulation of cell proliferationGO:0082858.8IL6, IL8, TNF

Molecular functions related to Spermatocele according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.1IL6, TNF

Products for genes affiliated with Spermatocele

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spermatocele

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet