MCID: SPR018
MIFTS: 21

Spermatocytoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Spermatocytoma

MalaCards integrated aliases for Spermatocytoma:

Name: Spermatocytoma 12 14
Spermatocytic Seminoma 12 29 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5834
NCIt 47 C39921
SNOMED-CT 64 9294008
UMLS 69 C0334517

Summaries for Spermatocytoma

MalaCards based summary : Spermatocytoma, also known as spermatocytic seminoma, is related to testicular spermatocytic seminoma and testicular germ cell tumor. An important gene associated with Spermatocytoma is SALL4 (Spalt Like Transcription Factor 4). Affiliated tissues include testis, and related phenotype is reproductive system.

Wikipedia : 72 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Related Diseases for Spermatocytoma

Graphical network of the top 20 diseases related to Spermatocytoma:



Diseases related to Spermatocytoma

Symptoms & Phenotypes for Spermatocytoma

MGI Mouse Phenotypes related to Spermatocytoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 CYP26B1 DMRT1 KIT NANOS3 SALL4

Drugs & Therapeutics for Spermatocytoma

Search Clinical Trials , NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

Genetic tests related to Spermatocytoma:

id Genetic test Affiliating Genes
1 Spermatocytic Seminoma 29

Anatomical Context for Spermatocytoma

MalaCards organs/tissues related to Spermatocytoma:

39
Testis

Publications for Spermatocytoma

Articles related to Spermatocytoma:

id Title Authors Year
1
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. ( 3034791 )
1987
2
(I) Spermatocytoma. ( 19988495 )
1932

Variations for Spermatocytoma

ClinVar genetic disease variations for Spermatocytoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
2 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889

Expression for Spermatocytoma

Search GEO for disease gene expression data for Spermatocytoma.

Pathways for Spermatocytoma

GO Terms for Spermatocytoma

Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 9.32 KIT SALL4
2 stem cell population maintenance GO:0019827 9.26 KIT SALL4
3 spermatogenesis GO:0007283 9.26 CYP26B1 DMRT1 KIT NANOS3
4 embryonic limb morphogenesis GO:0030326 9.16 CYP26B1 SALL4
5 germ cell migration GO:0008354 8.62 DMRT1 KIT

Sources for Spermatocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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