MCID: SPR018
MIFTS: 25

Spermatocytoma malady

Cancer diseases, Rare diseases, Reproductive diseases categories

Aliases & Classifications for Spermatocytoma

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 65UMLS, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Spermatocytoma:

Name: Spermatocytoma 10 12
 
Spermatocytic Seminoma 10 51 65


Classifications:



Characteristics (Orphanet epidemiological data):

51
spermatocytic seminoma:
Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:5834
NCIt42 C39921
Orphanet51 99865
SNOMED-CT59 9294008
UMLS via Orphanet66 C0334517
ICD10 via Orphanet28 C62

Summaries for Spermatocytoma

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Wikipedia:68 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

MalaCards based summary: Spermatocytoma, also known as spermatocytic seminoma, is related to seminoma and testicular spermatocytic seminoma. An important gene associated with Spermatocytoma is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways is PI3K-Akt signaling pathway. Affiliated tissues include testis, and related mouse phenotype reproductive system.

Related Diseases for Spermatocytoma

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Graphical network of the top 20 diseases related to Spermatocytoma:



Diseases related to spermatocytoma

Symptoms for Spermatocytoma

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Drugs & Therapeutics for Spermatocytoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

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Anatomical Context for Spermatocytoma

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MalaCards organs/tissues related to Spermatocytoma:

33
Testis

Animal Models for Spermatocytoma or affiliated genes

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MGI Mouse Phenotypes related to Spermatocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.4ALPP, DMRT1, FGFR3, KIT, NANOS3, SALL4

Publications for Spermatocytoma

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Articles related to Spermatocytoma:

idTitleAuthorsYear
1
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. (3034791)
1987
2
(I) Spermatocytoma. (19988495)
1932

Variations for Spermatocytoma

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Clinvar genetic disease variations for Spermatocytoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)single nucleotide variantPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889

Expression for genes affiliated with Spermatocytoma

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Search GEO for disease gene expression data for Spermatocytoma.

Pathways for genes affiliated with Spermatocytoma

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Pathways related to Spermatocytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1FGFR3, KIT, NANOS3

GO Terms for genes affiliated with Spermatocytoma

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Cellular components related to Spermatocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic side of plasma membraneGO:00098989.7FGFR3, KIT

Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat1 proteinGO:004251110.1FGFR3, KIT
2stem cell population maintenanceGO:001982710.0KIT, SALL4
3positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.9FGFR3, KIT
4positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.6FGFR3, KIT
5germ cell migrationGO:00083549.6DMRT1, KIT
6somatic stem cell population maintenanceGO:00350199.1FGFR3, KIT, SALL4

Sources for Spermatocytoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet