MCID: SPR018
MIFTS: 24

Spermatocytoma malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Spermatocytoma

About this section

Aliases & Descriptions for Spermatocytoma:

Name: Spermatocytoma 11 13
 
Spermatocytic Seminoma 11 27 68

Classifications:



External Ids:

Disease Ontology11 DOID:5834
SNOMED-CT62 9294008
NCIt45 C39921

Summaries for Spermatocytoma

About this section
Wikipedia:71 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

MalaCards based summary: Spermatocytoma, also known as spermatocytic seminoma, is related to testicular spermatocytic seminoma and testicular germ cell tumor. An important gene associated with Spermatocytoma is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways is Central carbon metabolism in cancer. Affiliated tissues include testis, and related mouse phenotypes are Increased senescence-associated beta-galactosidase protein expression after pRB stimulation and reproductive system.

Related Diseases for Spermatocytoma

About this section

Graphical network of diseases related to Spermatocytoma:



Diseases related to spermatocytoma

Symptoms & Phenotypes for Spermatocytoma

About this section

GenomeRNAi Phenotypes related to Spermatocytoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00230-A-210.5FGFR3, KIT

MGI Mouse Phenotypes related to Spermatocytoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5DMRT1, FGFR3, KIT, NANOS3, SALL4

Drugs & Therapeutics for Spermatocytoma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

About this section

Genetic tests related to Spermatocytoma:

id Genetic test Affiliating Genes
1 Spermatocytic Seminoma27

Anatomical Context for Spermatocytoma

About this section

MalaCards organs/tissues related to Spermatocytoma:

36
Testis

Publications for Spermatocytoma

About this section

Articles related to Spermatocytoma:

idTitleAuthorsYear
1
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. (3034791)
1987
2
(I) Spermatocytoma. (19988495)
1932

Variations for Spermatocytoma

About this section

Clinvar genetic disease variations for Spermatocytoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)SNVPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889

Expression for genes affiliated with Spermatocytoma

About this section
Search GEO for disease gene expression data for Spermatocytoma.

Pathways for genes affiliated with Spermatocytoma

About this section

Pathways related to Spermatocytoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8FGFR3, KIT

GO Terms for genes affiliated with Spermatocytoma

About this section

Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.5FGFR3, KIT
2positive regulation of tyrosine phosphorylation of Stat1 proteinGO:004251110.5FGFR3, KIT
3positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.5FGFR3, KIT
4regulation of phosphatidylinositol 3-kinase signalingGO:001406610.4FGFR3, KIT
5somatic stem cell population maintenanceGO:003501910.4KIT, SALL4
6germ cell migrationGO:000835410.4DMRT1, KIT
7stem cell population maintenanceGO:00198279.8KIT, SALL4
8spermatogenesisGO:00072839.6DMRT1, KIT, NANOS3

Molecular functions related to Spermatocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.8FGFR3, KIT

Sources for Spermatocytoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet