MCID: SPR018
MIFTS: 23

Spermatocytoma malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Spermatocytoma

Aliases & Descriptions for Spermatocytoma:

Name: Spermatocytoma 12 14
Spermatocytic Seminoma 12 29 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5834
NCIt 47 C39921
SNOMED-CT 64 9294008
UMLS 69 C0334517

Summaries for Spermatocytoma

MalaCards based summary : Spermatocytoma, also known as spermatocytic seminoma, is related to testicular spermatocytic seminoma and testicular germ cell tumor. An important gene associated with Spermatocytoma is SALL4 (Spalt Like Transcription Factor 4), and among its related pathways/superpathways is Central carbon metabolism in cancer. Affiliated tissues include testis, and related phenotype is Increased senescence-associated beta-galactosidase protein expression after pRB stimulation.

Wikipedia : 71 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Related Diseases for Spermatocytoma

Diseases related to Spermatocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 testicular spermatocytic seminoma 12.3
2 testicular germ cell tumor 11.9
3 seminoma 10.7
4 subendocardial myocardial infarction 10.1 KIT SALL4
5 sarcoma 10.0
6 lung mucoepidermoid carcinoma 10.0 KIT MAGEC1
7 epidermolysis bullosa simplex, recessive 1 9.9 FGFR3 KIT
8 rhabdomyosarcoma 9.9
9 sertoli cell tumor 9.9
10 prostate cancer, hereditary, x-linked 1 9.9 DMRT1 FGFR3 KIT
11 apical myocardial infarction 8.7 DDX3Y DMRT1 FGFR3 KIT MAGEA4 MAGEC1

Graphical network of the top 20 diseases related to Spermatocytoma:



Diseases related to Spermatocytoma

Symptoms & Phenotypes for Spermatocytoma

GenomeRNAi Phenotypes related to Spermatocytoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.62 FGFR3 KIT

Drugs & Therapeutics for Spermatocytoma

Search Clinical Trials , NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

Genetic tests related to Spermatocytoma:

id Genetic test Affiliating Genes
1 Spermatocytic Seminoma 29

Anatomical Context for Spermatocytoma

MalaCards organs/tissues related to Spermatocytoma:

39
Testis

Publications for Spermatocytoma

Articles related to Spermatocytoma:

id Title Authors Year
1
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. ( 3034791 )
1987
2
(I) Spermatocytoma. ( 19988495 )
1932

Variations for Spermatocytoma

ClinVar genetic disease variations for Spermatocytoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
2 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic/Likely pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889

Expression for Spermatocytoma

Search GEO for disease gene expression data for Spermatocytoma.

Pathways for Spermatocytoma

Pathways related to Spermatocytoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.44 FGFR3 KIT

GO Terms for Spermatocytoma

Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 9.4 KIT SALL4
2 stem cell population maintenance GO:0019827 9.37 KIT SALL4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 FGFR3 KIT
4 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.26 FGFR3 KIT
5 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.16 FGFR3 KIT
6 positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 8.96 FGFR3 KIT
7 germ cell migration GO:0008354 8.62 DMRT1 KIT

Molecular functions related to Spermatocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 FGFR3 KIT
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 FGFR3 KIT

Sources for Spermatocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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