MCID: SPR018
MIFTS: 24

Spermatocytoma malady

Reproductive diseases category

Summaries for Spermatocytoma

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testis or, more... more...

MalaCards: Spermatocytoma, also known as spermatocytic seminoma, is related to seminoma and testicular spermatocytic seminoma. An important gene associated with Spermatocytoma is DDX3Y (DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked), and among its related pathways are RNA transport and mRNA surveillance pathway. Affiliated tissues include testis, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Spermatocytoma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

spermatocytoma 8 10
spermatocytic seminoma 8 60


External Ids:

Disease Ontology8 DOID:5834
SNOMED-CT56 9294008
NCIt39 C39921

Related Diseases for Spermatocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Spermatocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma11.0
2testicular spermatocytic seminoma10.5
3sarcoma10.3
4testis seminoma10.3
5spermatocytic seminoma, somatic10.3
6sertoli cell tumor10.2
7rhabdomyosarcoma10.2
8testicular cancer10.2
9male germ cell tumor, somatic10.2
10in situ carcinoma10.0
11azoospermia10.0DDX3Y, SYCP1
12male infertility10.0SYCP1, DDX3Y
13teratoma10.0SALL4
14infertility10.0SYCP1, STRA8

Graphical network of diseases related to Spermatocytoma:



Diseases related to spermatocytoma

Clinical Features for Spermatocytoma

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Drugs & Therapeutics for Spermatocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Spermatocytoma

Search CenterWatch for Spermatocytoma

Genetic Tests for Spermatocytoma

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Anatomical Context for Spermatocytoma

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32MalaCards
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MalaCards organs/tissues related to Spermatocytoma:

32
Testis

Animal Models for Spermatocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spermatocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2NXF2, NANOS2, SYCP1, STRA8
2MP:00053897.5NXF2, NANOS2, SYCP1, STRA8, SALL4

Publications for Spermatocytoma

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50PubMed
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Articles related to Spermatocytoma:

idTitleAuthorsYear
1
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. (3034791)
1987
2
(I) Spermatocytoma. (19988495)
1932

Genetic Variations for Spermatocytoma

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Expression for genes affiliated with Spermatocytoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spermatocytoma

Search GEO for disease gene expression data for Spermatocytoma.

Pathways for genes affiliated with Spermatocytoma

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Sources:
29KEGG
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Pathways related to Spermatocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4NXF2, NXF2B
29.4NXF2, NXF2B
39.4NXF2, NXF2B

Compounds for genes affiliated with Spermatocytoma

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GO Terms for genes affiliated with Spermatocytoma

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Sources:
16Gene Ontology
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Biological processes related to Spermatocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1reciprocal meiotic recombinationGO:0071318.8SYCP1, STRA8
2spermatogenesisGO:0072838.6NANOS2, SYCP1, STRA8

Molecular functions related to Spermatocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037239.0NXF2B, NANOS2, DDX3Y

Products for genes affiliated with Spermatocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spermatocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet