MCID: SPR018
MIFTS: 24

Spermatocytoma malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Spermatocytoma

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Aliases & Descriptions for Spermatocytoma:

Name: Spermatocytoma 11 13
 
Spermatocytic Seminoma 11 26 67

Classifications:



External Ids:

Disease Ontology11 DOID:5834
SNOMED-CT61 9294008
NCIt44 C39921

Summaries for Spermatocytoma

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Wikipedia:70 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

MalaCards based summary: Spermatocytoma, also known as spermatocytic seminoma, is related to testicular spermatocytic seminoma and testicular germ cell tumor. An important gene associated with Spermatocytoma is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways is Central carbon metabolism in cancer. Affiliated tissues include testis, and related mouse phenotype reproductive system.

Related Diseases for Spermatocytoma

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Graphical network of diseases related to Spermatocytoma:



Diseases related to spermatocytoma

Symptoms for Spermatocytoma

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Drugs & Therapeutics for Spermatocytoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

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Genetic tests related to Spermatocytoma:

id Genetic test Affiliating Genes
1 Spermatocytic Seminoma26

Anatomical Context for Spermatocytoma

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MalaCards organs/tissues related to Spermatocytoma:

35
Testis

Animal Models for Spermatocytoma or affiliated genes

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MGI Mouse Phenotypes related to Spermatocytoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5DMRT1, FGFR3, KIT, NANOS3, SALL4

Publications for Spermatocytoma

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Articles related to Spermatocytoma:

idTitleAuthorsYear
1
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. (3034791)
1987
2
(I) Spermatocytoma. (19988495)
1932

Variations for Spermatocytoma

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Clinvar genetic disease variations for Spermatocytoma:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR3NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu)SNVPathogenicrs78311289GRCh37Chr 4, 1807889: 1807889

Expression for genes affiliated with Spermatocytoma

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Search GEO for disease gene expression data for Spermatocytoma.

Pathways for genes affiliated with Spermatocytoma

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Pathways related to Spermatocytoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8FGFR3, KIT

GO Terms for genes affiliated with Spermatocytoma

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Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat1 proteinGO:004251110.3FGFR3, KIT
2positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.3FGFR3, KIT
3regulation of phosphatidylinositol 3-kinase signalingGO:001406610.2FGFR3, KIT
4positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.2FGFR3, KIT
5germ cell migrationGO:000835410.0DMRT1, KIT
6stem cell population maintenanceGO:00198279.8KIT, SALL4
7somatic stem cell population maintenanceGO:00350199.8KIT, SALL4
8spermatogenesisGO:00072839.2DMRT1, KIT, NANOS3

Molecular functions related to Spermatocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.8FGFR3, KIT

Sources for Spermatocytoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet