MCID: SPR062
MIFTS: 33

Spermatogenic Failure malady

Genetic diseases, Reproductive diseases, Rare diseases categories
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Summaries for Spermatogenic Failure

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MalaCards based summary: Spermatogenic Failure is related to spermatogenic failure 6 and azoospermia. An important gene associated with Spermatogenic Failure is DAZL (deleted in azoospermia-like), and among its related pathways is Ovarian Infertility Genes. Affiliated tissues include testis, testes and prostate, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Spermatogenic Failure

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Spermatogenic Failure, Aliases & Descriptions:

Name: Spermatogenic Failure 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Reproductive diseases


Related Diseases for Spermatogenic Failure

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Graphical network of the top 20 diseases related to Spermatogenic Failure:



Diseases related to spermatogenic failure

Symptoms for Spermatogenic Failure

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Drugs & Therapeutics for Spermatogenic Failure

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Drug clinical trials:

Search ClinicalTrials for Spermatogenic Failure

Search NIH Clinical Center for Spermatogenic Failure

Genetic Tests for Spermatogenic Failure

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Anatomical Context for Spermatogenic Failure

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MalaCards organs/tissues related to Spermatogenic Failure:

32
Testis, Testes, Prostate

Animal Models for Spermatogenic Failure or affiliated genes

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MGI Mouse Phenotypes related to Spermatogenic Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3NR5A1, DPY19L2, SEPT12, DAZL
2MP:00053897.4SLC26A8, NR5A1, DPY19L2, SEPT12, DAZL

Publications for Spermatogenic Failure

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Articles related to Spermatogenic Failure:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Altered gene expression signature of early stages of the germ line supports the pre-meiotic origin of human spermatogenic failure. (24803180)
2014
2
Azoospermia due to spermatogenic failure. (24286770)
2014
3
Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. (23608167)
2013
4
Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1. (23555275)
2013
5
Genetic causes of spermatogenic failure. (22138898)
2012
6
AZFc deletions and spermatogenic failure: a population-based survey of 20,000 Y chromosomes. (23103232)
2012
7
Male factor infertility: testis explantation for spermatogenic failure. (23027066)
2012
8
Autosomal mutations and human spermatogenic failure. (22841926)
2012
9
A single-nucleotide polymorphism of the DAZL gene promoter confers susceptibility to spermatogenic failure in the Taiwanese Han. (22752612)
2012
10
Medical therapy for spermatogenic failure. (22179517)
2012
11
Haplotype analysis of ESR2 in Japanese patients with spermatogenic failure. (22622360)
2012
12
Decrease of anti-Mullerian hormone in genetic spermatogenic failure. (21486417)
2012
13
X chromosomal mutations and spermatogenic failure. (22634129)
2012
14
DAX-1 and DAX-1A expression in human testicular tissues with primary spermatogenic failure. (21775412)
2011
15
R171H missense mutation of INSL6 in a patient with spermatogenic failure. (21616179)
2011
16
Unravelling the genetics of spermatogenic failure. (19776097)
2010
17
P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure. (19906189)
2010
18
Androgen receptor gene CAG and GGN repeat polymorphisms in Chilean men with primary severe spermatogenic failure. (20378930)
2010
19
Lack of association between DAZ gene methylation patterns and spermatogenic failure. (20170395)
2010
20
Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. (20940137)
2010
21
Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress. (21182756)
2010
22
Bacterial LPS-mediated acute inflammation-induced spermatogenic failure in rats: role of stress response proteins and mitochondrial dysfunction. (20087639)
2010
23
Mutations in the protamine locus: association with spermatogenic failure? (19602509)
2009
24
A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India. (20300286)
2008
25
CAG repeat length variation in the androgen receptor gene is not associated with spermatogenic failure. (17889867)
2008
26
Propecia-induced spermatogenic failure: a report of two cases. (18054928)
2008
27
Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men. (17114206)
2007
28
AZFc partial deletions in Chilean men with severe spermatogenic failure. (17416365)
2007
29
Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response. (17921478)
2007
30
The association of Y chromosome haplogroups with spermatogenic failure in the Han Chinese. (17558462)
2007
31
GR/GR deletions within the azoospermia factor c region on the Y chromosome might not be associated with spermatogenic failure. (16412764)
2006
32
Association of DAZL haplotypes with spermatogenic failure in infertile men. (16730721)
2006
33
Decrease of both stem cell factor and clusterin mRNA levels in testicular biopsies of azoospermic patients with constitutive or idiopathic but not acquired spermatogenic failure. (16709604)
2006
34
A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population. (16573709)
2006
35
Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure. (15713828)
2005
36
Meiotic studies in two human reciprocal translocations and their association with spermatogenic failure. (15689348)
2005
37
Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure. (15579655)
2005
38
Expression levels of the inhibitor of apoptosis survivin in testes of patients with normal spermatogenesis and spermatogenic failure. (15831281)
2005
39
DAZL polymorphisms and susceptibility to spermatogenic failure: an example of remarkable ethnic differences. (15595957)
2004
40
Expression of proto-oncogene c-kit receptor in rats (Rattus norvegicus) and identification of a mutant mRNA transcript implicated in spermatogenic failure. (12932303)
2003
41
A nation-based population screening for azoospermia factor deletions in Greek-Cypriot patients with severe spermatogenic failure and normal fertile controls, using a specific study and experimental design. (12031043)
2002
42
Gene-based screening for Y chromosome deletions in Taiwanese men presenting with spermatogenic failure. (12009341)
2002
43
AZFa candidate gene deletions in Taiwanese patients with spermatogenic failure. (11695273)
2001
44
Serum levels of inhibin B in men with different causes of spermatogenic failure. (10363117)
1999
45
Identification of spermatozoa and round spermatids in the ejaculates of men with spermatogenic failure. (9610597)
1998
46
Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal of testosterone. (8385423)
1993
47
An aspermia rat mutant (as/as) with spermatogenic failure at meiosis. (1327181)
1992
48
The role of unpaired sex chromosomes in spermatogenic failure. (1519771)
1992
49
Spermatogenic failure in male mice lacking H-Y antigen. (3951555)
1986
50
Spermatogenic failure of translocation heterozygotes affected by H-2-linked gene in mouse. (1256555)
1976

Variations for Spermatogenic Failure

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Expression for genes affiliated with Spermatogenic Failure

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Expression patterns in normal tissues for genes affiliated with Spermatogenic Failure

Search GEO for disease gene expression data for Spermatogenic Failure.

Pathways for genes affiliated with Spermatogenic Failure

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Pathways related to Spermatogenic Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NR5A1, DAZL

Compounds for genes affiliated with Spermatogenic Failure

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GO Terms for genes affiliated with Spermatogenic Failure

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Biological processes related to Spermatogenic Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell differentiationGO:0301548.5SLC26A8, NR5A1, SPATA16
2spermatogenesisGO:0072838.4USP9Y, DAZL, SPATA16, SLC26A8
3multicellular organismal developmentGO:0072758.2SLC26A8, DAZL, SPATA16, DPY19L2

Products for genes affiliated with Spermatogenic Failure

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Sources for Spermatogenic Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet