MCID: SPR062
MIFTS: 24

Spermatogenic Failure malady

Reproductive diseases category

Summaries for Spermatogenic Failure

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32MalaCards
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MalaCards: Spermatogenic Failure is related to infertility and azoospermia. An important gene associated with Spermatogenic Failure is DAZL (deleted in azoospermia-like), and among its related pathways is Ovarian Infertility Genes. The compound protamine have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Aliases & Classifications for Spermatogenic Failure

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

spermatogenic failure 46


Related Diseases for Spermatogenic Failure

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17GeneCards, 18GeneDecks
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Diseases in the Spermatogenic Failure 4 family:

Spermatogenic Failure 5 Spermatogenic Failure 6
Spermatogenic Failure 8 Spermatogenic Failure 9
Spermatogenic Failure 2 spermatogenic failure
Spermatogenic Failure 3 Spermatogenic Failure 12
Spermatogenic Failure 7 Spermatogenic Failure 10
Spermatogenic Failure 11

Diseases related to Spermatogenic Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.6AZF1, DAZ2, PRM1, DAZ1, DAZ4, DAZL
2azoospermia30.5AZF1, USP9Y, DDX3Y, PRM1, DAZL, DAZ4
3male infertility30.3DAZ3, SPATA16, TAF7L, DPY19L2, TNP2, PRM1
4varicocele30.0AZF1
5y chromosome infertility30.0USP9Y, DDX3Y, DAZ1
6spermatogenic failure 410.5
7spermatogenic failure 910.5
8spermatogenic failure 810.4
9spermatogenic failure, y-linked, 210.4
10spermatogenic failure 510.3
11spermatogenic failure 610.3
12spermatogenic failure 710.3
13spermatogenic failure 210.2
14spermatogenic failure 310.2
15spermatogenic failure 1210.2
16spermatogenic failure 1010.2
17spermatogenic failure 1110.2
18spermatogenic failure, x-linked, 210.2
19spermatogenic failure, y-linked, 110.2
20prostate cancer10.0
21prostatitis10.0
22sporadic hemiplegic migraine10.0
23gonadal dysgenesis10.0NR5A1
24cryptorchidism10.0DAZ1, NR5A1, AZF1
25sertoli cell-only syndrome10.0DDX3Y, USP9Y, DAZ1, DAZ2
26klinefelter's syndrome10.0AZF1, DAZ4, NR5A1
27globozoospermia10.0SPATA16
28smith magenis syndrome10.0DAZ1, DAZL, USP9Y, AZF1
29oligospermia10.0DAZ1, USP9Y, AZF1, DAZL, DAZ4, DDX3Y

Graphical network of the top 20 diseases related to Spermatogenic Failure:



Diseases related to spermatogenic failure

Clinical Features for Spermatogenic Failure

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Drugs & Therapeutics for Spermatogenic Failure

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Spermatogenic Failure

Drug clinical trials:

Search ClinicalTrials for Spermatogenic Failure

Search NIH Clinical Center for Spermatogenic Failure

Search CenterWatch for Spermatogenic Failure

Genetic Tests for Spermatogenic Failure

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Anatomical Context for Spermatogenic Failure

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Animal Models for Spermatogenic Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spermatogenic Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0NR5A1, DPY19L2, TAF7L, DAZL, SEPT12
2MP:00053899.1SEPT12, AURKC, TNP2, PRM3, PRM1, NR5A1

Publications for Spermatogenic Failure

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Genetic Variations for Spermatogenic Failure

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Expression for genes affiliated with Spermatogenic Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spermatogenic Failure

Search GEO for disease gene expression data for Spermatogenic Failure.

Pathways for genes affiliated with Spermatogenic Failure

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37NCBI BioSystems Database
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Pathways related to Spermatogenic Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3DAZL, NR5A1

Compounds for genes affiliated with Spermatogenic Failure

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44Novoseek
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Compounds related to Spermatogenic Failure according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1protamine4410.2PRM1, TNP2

GO Terms for genes affiliated with Spermatogenic Failure

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16Gene Ontology
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Cellular components related to Spermatogenic Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleosomeGO:0007869.9PRM1, PRM3, TNP2
2nucleusGO:0056349.2TNP2, DDX3Y, PRM3, NR5A1, DAZL, DAZ4
3cytoplasmGO:0057378.9AURKC, USP9Y, DDX3Y, PRM3, TAF7L, DAZL

Biological processes related to Spermatogenic Failure according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1spermatid developmentGO:00728610.4DPY19L2
2positive regulation of translational initiationGO:04594810.3DAZL, DAZ1
3chromosome condensationGO:03026110.1PRM1, PRM3
4sperm motilityGO:0303179.9PRM3, TNP2
5cell differentiationGO:0301549.2NR5A1, PRM1, PRM3, TNP2, TAF7L, DAZ4
6spermatogenesisGO:0072839.2SPATA16, TNP2, USP9Y, PRM3, PRM1, TAF7L
7multicellular organismal developmentGO:0072759.2DPY19L2, PRM1, PRM3, TNP2, TAF7L, DAZL

Molecular functions related to Spermatogenic Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation activator activityGO:00849410.3DAZ1, DAZL
2nucleotide bindingGO:0001669.8DAZ2, DAZ3, DAZ1, DAZ4, DAZL
3RNA bindingGO:0037239.4DDX3Y, DAZL, DAZ4, DAZ1, DAZ3, DAZ2

Products for genes affiliated with Spermatogenic Failure

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Spermatogenic Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet