MCID: SPN038
MIFTS: 67

Spina Bifida malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Spina Bifida

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22Genetics Home Reference, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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NINDS:45 Spina bifida (SB) is a neural tube defect (a disorder involving incomplete development of the brain, spinal cord, and/or their protective coverings) caused by the failure of the fetus's spine to close properly during the first month of pregnancy. Infants born with SB sometimes have an open lesion on their spine where significant damage to the nerves and spinal cord has occurred. Although the spinal opening can be surgically repaired shortly after birth, the nerve damage is permanent, resulting in varying degrees of paralysis of the lower limbs. Even when there is no lesion present there may be improperly formed or missing vertebrae and accompanying nerve damage. In addition to physical and mobility difficulties, most individuals have some form of learning disability. The types of SB are: myelomeningocele, the severest form, in which the spinal cord and its protective covering (the meninges) protrude from an opening in the spine; meningocele in which the spinal cord develops normally but the meninges and spinal fluid) protrude from a spinal opening; closed neural tube defects, which consist of a group of defects in which development of the spinal cord is affected by malformations of the fat, bone, or meninges; and and occulta, the mildest form, in which one or more vertebrae are malformed and covered by a layer of skin. SB may also cause bowel and bladder complications, and many children with SB have hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain).

MalaCards: Spina Bifida, also known as spinal dysraphism, is related to spina bifida occulta and anencephaly. An important gene associated with Spina Bifida is CCL2 (chemokine (C-C motif) ligand 2), and among its related pathways are Folate Metabolism and Wnt / Hedgehog / Notch. The compounds ch2h4folate and 5,10-methenyltetrahydrofolate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are other and pigmentation.

Genetics Home Reference:22 Spina bifida is a condition in which the bones of the spinal column do not close completely around the developing nerves of the spinal cord. As a result, part of the spinal cord may stick out through an opening in the spine, leading to permanent nerve damage. Spina bifida results when a structure called the neural tube fails to close completely during the first few weeks of embryonic development. The neural tube is a layer of cells that ultimately develops into the brain and spinal cord. Because spina bifida is caused by abnormalities of the neural tube, it is classified as a neural tube defect (NTD).

NIH Rare Diseases:44 Spina bifida is a type of neural tube defect in which the bones of the spinal column do not close completely around the developing nerves of the spinal cord during the development of the embryo. as a result, part of the spinal cord may stick out through an opening in the spine, leading to permanent nerve damage. children born with spina bifida often have a fluid-filled sac on their back covered by skin. if the sac contains part of the spinal cord and its protective covering, it is known as a myelomeningocele; if it does not, it is known as a meningocele. the signs and symptoms range from mild to severe (depending on the location and extent of spinal cord involvement) and can include a loss of feeling below the level of the opening; weakness or paralysis of the feet or legs; problems with bladder and bowel control; hydrocephalus; and learning problems. with surgery and other forms of treatment, many people with spina bifida live into adulthood. there is also a milder form of the condition called spina bifida occulta. last updated: 5/9/2011

MedlinePlus:35 Spina bifida is a neural tube defect - a type of birth defect of the brain, spine, or spinal cord. it happens if the spinal column of the fetus doesn't close completely during the first month of pregnancy. this can damage the nerves and spinal cord. screening tests during pregnancy can check for spina bifida. sometimes it is discovered only after the baby is born. the symptoms of spina bifida vary from person to person. most people with spina bifida are of normal intelligence. some people need assistive devices such as braces, crutches, or wheelchairs. they may have learning difficulties, urinary and bowel problems, or hydrocephalus, a buildup of fluid in the brain. the exact cause of spina bifida is unknown. it seems to run in families. taking folic acid can reduce the risk of having a baby with spina bifida. it's in most multivitamins. women who could become pregnant should take it daily. nih: national institute of neurological disorders and stroke

Wikipedia:66 Spina bifida (Latin: \"split spine\") is a developmental congenital disorder caused by the incomplete... more...

Description from OMIM:48 182940

Aliases & Classifications for Spina Bifida

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9Disease Ontology, 44NIH Rare Diseases, 22Genetics Home Reference, 45NINDS, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

spina bifida 9 44 22 45 48 11 46 35
spinal dysraphism 44 22
rachischisis 44 22
cleft spine 44 22
open spine 44 22


External Ids:

Disease Ontology9 DOID:0080016
ICD1026 Q05, Q05.4

Related Diseases for Spina Bifida

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Spina Bifida:



Diseases related to spina bifida

Symptoms for Spina Bifida

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48OMIM
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Clinical features from OMIM:

182940

Drugs & Therapeutics for Spina Bifida

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spina Bifida

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Anatomical Context for Spina Bifida

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32LifeMap Discovery™, 34MalaCards
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MalaCards organs/tissues related to Spina Bifida:

34
Spinal cord, Brain, Bone, Skin, Testes, Kidney, Colon, Heart, Cerebellum, Dorsal root ganglion, Temporal lobe, Bone marrow, Endothelial, Breast, Lung, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Spina Bifida:
id TissueAnatomical CompartmentCell Relevance
1 Neural TubeNeural Tube  Affected by disease

Animal Models for Spina Bifida or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Spina Bifida:

38 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.9PTCH1, MTHFD1, CELSR1, VANGL2
2MP:00011869.7CCL2, FUZ, PTCH1, ZIC2
3MP:00053779.5VANGL1, FUZ, ALDH1A2, FOLR1, VANGL2, CELSR1
4MP:00020069.5PTCH1, SCRIB, AFP, CCL2, BHMT, FOLR1
5MP:00053679.4VANGL2, SCRIB, T, DACT1, PTCH1, BHMT
6MP:00053699.3ALDH1A2, ZIC1, CCL2, PTCH1, FUZ, PCMT1
7MP:00053889.3FUZ, ALDH1A2, VANGL1, PCMT1, CELSR1, VANGL2
8MP:00053799.3ALDH1A2, FOLR1, PTCH1, SCRIB, AFP, FUZ
9MP:00053979.2CELSR1, PTCH1, ALDH1A2, CCL2, MTHFD1, PCMT1
10MP:00053819.2FOLR1, VANGL2, PTCH1, SCRIB, T, FUZ
11MP:00107719.2CCL2, ZIC2, MTHFR, CELSR1, PTCH1, T
12MP:00053899.1AFP, T, DACT1, MTHFR, PTCH1, VANGL2
13MP:00028739.1VANGL1, ALDH1A2, VANGL2, CCL2, PTCH1, T
14MP:00053919.1SCRIB, PTCH1, FOLR1, ALDH1A2, MTHFR, CCL2
15MP:00053829.0VANGL2, PTCH1, T, FUZ, CELSR1, FOLR1
16MP:00053858.8CCL2, ZIC2, PTCH1, VANGL2, FUZ, VANGL1
17MP:00053868.8T, PCMT1, ZIC2, ZIC1, CCL2, PTCH1
18MP:00053718.5CELSR1, DACT1, ALDH1A2, ZIC2, MTHFR, MTHFD1
19MP:00053808.5SCRIB, T, DACT1, FOLR1, CELSR1, PTCH1
20MP:00053908.4DACT1, ZIC1, FUZ, T, PTCH1, VANGL2
21MP:00053768.2CCL2, CELSR1, VANGL2, AFP, T, FUZ
22MP:00036317.6SCRIB, T, VANGL1, CELSR1, DACT1, VANGL2
23MP:00053787.6BHMT, DACT1, T, SCRIB, VANGL2, PTCH1
24MP:00107687.4ZIC1, VANGL2, FOLR1, MTHFD1, MTHFR, ZIC2

Publications for Spina Bifida

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53PubMed
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Articles related to Spina Bifida:

(show top 50)    (show all 986)
idTitleAuthorsYear
1
Fetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experience. (24299030)
2014
2
Left-sided Poland's syndrome in a girl with rare associations like spina bifida and diaphragmatic hernia. (24057335)
2013
3
Evidence for spatial navigational impairments in hydrocephalus patients without spina bifida. (23959082)
2013
4
Lumbo-sacral malformations and spina bifida occulta in medieval skeletons from Brittany. (23412445)
2013
5
Neural activity generated in the neural placode and nerve roots in the neonate with spina bifida. (22462714)
2012
6
Letter to the editor: Spina bifida and neuropsychology. (22546037)
2012
7
Distribution of affected muscles and degree of neurogenic lesion in patients with spina bifida. (22328890)
2011
8
Early infantile electroencephalography in patients with spina bifida*. (21800274)
2011
9
Computer-mediated support for adolescents with cerebral palsy or spina bifida. (21099541)
2011
10
Bladder augmentation versus urinary diversion in patients with spina bifida in the United States. (21575969)
2011
11
Sensory tract abnormality in the chick model of spina bifida. (21658418)
2011
12
Detecting open spina bifida at the 11-13-week scan by assessing intracranial translucency and the posterior brain region: mid-sagittal or axial plane? (22411445)
2011
13
The urologist's role in the management of spina bifida: a continuum of care. (20350747)
2010
14
Orthopedic management of spina bifida. (20419777)
2010
15
Inferential ability in children with cerebral palsy, spina bifida and pragmatic language impairment. (19800759)
2010
16
The role of the retrograde colonic enema in children with spina bifida: is it inferior to the antegrade continence enema? (20198477)
2010
17
Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. (19683694)
2009
18
The experience of self-management in adolescent women with spina bifida. (19160922)
2009
19
Role of prenatal ultrasound in predicting survival and mental and motor functioning in children with spina bifida. (19670337)
2009
20
Spatial cognition and motor development: a study of children with spina bifida. (18556900)
2008
21
Bio-monitoring the elimination of folic acid-preventable spina bifida and anencephaly. (18585451)
2008
22
GDNF plasma levels in spina bifida: correlation with severity of spinal damage and motor function. (19125682)
2008
23
Interpreting changes in the epidemiology of anencephaly and spina bifida following folic acid fortification of the U.S. grain supply in the setting of long-term trends, Atlanta, Georgia, 1968-2003. (17990332)
2007
24
Natural rubber latex sensitisation and allergy in patients with spina bifida, urogenital disorders and oesophageal atresia compared with a normal paediatric population. (17638159)
2007
25
Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida. (16523512)
2006
26
Evaluation of sexual function in young men with spina bifida and myelomeningocele using the International Index of Erectile Function. (16504267)
2006
27
Rehabilitating the neurogenic bladder: the role of artificial neural reflex pathways in children with spina bifida. (16526998)
2006
28
CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. (17184542)
2006
29
Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus. (15039923)
2004
30
Spina bifida occulta as a relative contraindication for percutaneous retrograde lead insertion for sacral nerve root stimulation. (22151780)
2002
31
Spina bifida and folate-related genes: a study of gene-gene interactions. (12180146)
2002
32
The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy. (9863598)
1998
33
Neurological dysfunction above cele level in children with spina bifida cystica. (9926334)
1998
34
Spinal hematoma following spinal anesthesia in a patient with spina bifida occulta. (9357903)
1997
35
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
36
Cervical flexion myelopathy associated with cervical spina bifida occulta--case report. (7566384)
1995
37
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. (1283633)
1992
38
Prevalence of spina bifida occulta in patients with functional disorders of the lower urinary tract and its relation to urodynamic and neurophysiological measurements. (2493933)
1989
39
Neurophysiological measurements in patients with genuine stress incontinence of urine and the relation of neurogenic defects to the presence of spina bifida occulta. (3044478)
1988
40
Investigation of a cluster of anencephaly and spina bifida. (6383023)
1984
41
Factors affecting the ambulatory status of patients with spina bifida cystica. (6600743)
1983
42
Comparison of alphafetoprotein and beta-trace protein in the antenatal diagnosis of anencephaly and spina bifida. (57018)
1976
43
Amniotic fluid alpha2-macroglobulin and the antenatal diagnosis of spina bifida and anencephaly. (52422)
1975
44
The renal tract in spina bifida cystica. (4569783)
1972
45
Neuroschisis and human embryonic maldevelopment. New evidence on anencephaly, spina bifida and diverse mammalian defects. (4985177)
1970
46
The long-term evaluation of a trial of immediate and delayed closure of spina bifida cystica. (5339471)
1967
47
THE NATURAL HISTORY OF SPINA BIFIDA CYSTICA: DETAILED ANALYSIS OF 407 CASES. (14160086)
1964
48
Incidence of spina bifida occulta in relation to age. (13301135)
1956
49
Late neurologic symptoms of spina bifida occulta: report of case. (13297807)
1956
50
II. Cases of Operation in Spina Bifida and Encephalocele. (17859817)
1892

Variations for Spina Bifida

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Spina Bifida:

65 (show all 12)
id Symbol AA change Variation ID SNP ID
1CELSR1p.Ala773ValVAR_067213rs12170597
2CELSR1p.Arg2438GlnVAR_067215rs199688538
3CELSR1p.Ser2964LeuVAR_067217rs6008777
4CELSR1p.Pro2983AlaVAR_067218rs61741871
5DACT1p.Asn356LysVAR_068429
6SCRIBp.Pro454SerVAR_067219
7SCRIBp.Arg1535GlnVAR_067220
8VANGL1p.Arg274GlnVAR_035210
9VANGL1p.Met328ThrVAR_035211
10VANGL2p.Ser84PheVAR_067221
11VANGL2p.Arg353CysVAR_067222
12VANGL2p.Phe437SerVAR_067223

Clinvar genetic disease variations for Spina Bifida:

1
id Gene Name Type Significance SNP ID Assembly Location
1VANGL1NM_138959.2(VANGL1): c.821G> A (p.Arg274Gln)single nucleotide variantPathogenicrs121918219GRCh37Chr 1, 116224993: 116224993
2VANGL1NM_138959.2(VANGL1): c.983T> C (p.Met328Thr)single nucleotide variantPathogenicrs121918220GRCh37Chr 1, 116226601: 116226601
3CCL2NG_012123.1: g.2493A> Gsingle nucleotide variantPathogenic, risk factorrs1024611GRCh37Chr 17, 32579788: 32579788
4FUZNM_025129.4(FUZ): c.115C> T (p.Pro39Ser)single nucleotide variantPathogenicrs387907204GRCh37Chr 19, 50315990: 50315990
5FUZNM_025129.4(FUZ): c.1060G> T (p.Asp354Tyr)single nucleotide variantPathogenicrs139365610GRCh37Chr 19, 50310605: 50310605
6FUZFUZZY, ARG404GLUsingle nucleotide variantPathogenic
7VANGL2NM_020335.2(VANGL2): c.1057C> T (p.Arg353Cys)single nucleotide variantPathogenicrs267607167GRCh37Chr 1, 160390961: 160390961
8VANGL2NM_020335.2(VANGL2): c.1310T> C (p.Phe437Ser)single nucleotide variantPathogenicrs267607168GRCh37Chr 1, 160394912: 160394912

Expression for genes affiliated with Spina Bifida

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spina Bifida

Search GEO for disease gene expression data for Spina Bifida.

Pathways for genes affiliated with Spina Bifida

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51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 56Reactome, 31KEGG, 52PharmGKB, 61Thomson Reuters
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Pathways related to Spina Bifida according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism39
10.0MTRR, MTHFR
29.7PTCH1, SCRIB, AFP, T
3
Show member pathways
flavin biosynthesis IV (mammalian)39
molybdenum cofactor biosynthesis39
coenzyme A biosynthesis39
thiamin salvage III39
alanine biosynthesis III39
thio-molybdenum cofactor biosynthesis39
biotin-carboxyl carrier protein assembly39
9.5DHFR, MTHFD1, MTHFR, MTRR
4
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.3BHMT, MTRR, MTHFR, MTHFD1, DHFR

Compounds for genes affiliated with Spina Bifida

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46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Spina Bifida according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4610.5MTHFD1, MTHFR
25,10-methenyltetrahydrofolate4610.4MTHFD1, MTHFR
3vitamin b-complex, plain5210.4MTRR, MTHFR
45,10-Methylene-THF2510.4MTHFD1, MTHFR
5methylcobalamin46 2511.3MTHFR, MTRR
6b vitamins4610.3MTHFR, MTRR
7multivitamin4610.3DHFR, MTHFR
8pemetrexed52 1211.3DHFR, MTHFR
9hydroxocobalamin46 1211.3MTHFR, MTRR
10cyanocobalamin52 25 1212.2MTRR, MTHFR
11cobalamin46 2511.2MTHFR, MTHFD1, MTRR
12trimetrexate46 1211.2DHFR, FOLR1
13vitamin b64610.2BHMT, MTHFD1, MTHFR
1410-formyltetrahydrofolate4610.2MTHFD1, DHFR, MTHFR
15Tetrahydrofolic acid25 1211.2MTHFD1, DHFR, MTHFR
16betaine46 2511.2MTRR, BHMT, MTHFR
175-methyltetrahydrofolate46 1211.2MTRR, FOLR1, MTHFR
18riboflavin46 25 1212.2MTHFR, MTRR, BHMT
19s-adenosylhomocysteine46 2511.2PCMT1, MTHFR, MTRR
20bleomycin46 1211.1AFP, CCL2, DHFR
21tetrahydrofolate4610.1MTRR, MTHFR, DHFR
22L-Methionine25 1211.1MTRR, BHMT
23tomudex4610.1DHFR, FOLR1
24dihydrofolate4610.1FOLR1, MTHFR, DHFR
25leucovorin46 52 1212.1FOLR1, DHFR, MTHFR
26methylmalonic acid46 2511.1MTRR, MTHFR
27cyclophosphamide46 52 1212.0MTHFR, CCL2, AFP, DHFR
28cystathionine4610.0BHMT, MTRR, MTHFR, MTHFD1
295fluorouracil4610.0MTHFR, CCL2, AFP, DHFR
30acyclovir46 1211.0DHFR, AFP
31purine46 2511.0MTHFD1, MTHFR, DHFR
32s-adenosylmethionine46 25 1212.0MTRR, MTHFR, PCMT1, BHMT
33vitamin b12469.9BHMT, MTRR, MTHFR, CCL2, AFP
34folic acid52 25 1211.9DHFR, MTRR, MTHFR, FOLR1
35NADP259.9MTRR, MTHFR, MTHFD1, DHFR
36nadh46 25 1211.9MTHFR, MTHFD1, DHFR, ALDH1A2
37valine469.8AFP, DHFR, MTHFR
38cisplatin46 52 62 1212.8AFP, DHFR, CCL2, MTHFR, FOLR1
39nadph46 2510.7MTRR, MTHFD1, CCL2, DHFR, MTHFR
40methionine469.7FOLR1, MTRR, MTHFR, BHMT, MTHFD1
41carbon469.7MTHFR, DHFR, AFP
42thymidylate469.7MTHFR, DHFR, MTRR, MTHFD1, FOLR1
43aspartate469.6PCMT1, MTHFR, DHFR, MTRR, AFP, CCL2
44homocysteine46 2510.6MTRR, BHMT, FOLR1, CCL2, MTHFR, MTHFD1
45FAD259.5MTRR, ALDH1A2, MTHFR
46methotrexate52 46 1211.5DHFR, AFP, MTRR, MTHFR, MTHFD1, FOLR1
47zinc46 2510.4BHMT, ZIC2, ZIC1, AFP, PTCH1
48alanine469.4MTRR, ZIC2, DHFR, AFP, MTHFR
49folate469.3FOLR1, BHMT, MTRR, AFP, DHFR, MTHFD1
50serine469.1CCL2, BHMT, FOLR1, DHFR, MTHFD1, MTRR

GO Terms for genes affiliated with Spina Bifida

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17Gene Ontology
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Cellular components related to Spina Bifida according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.1BHMT, FUZ, T, AFP, CCL2, MTRR

Biological processes related to Spina Bifida according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1lateral sprouting involved in lung morphogenesisGO:06049010.5VANGL2, CELSR1
2planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048910.5VANGL2, CELSR1
3orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048810.5VANGL2, CELSR1
4establishment of body hair planar orientationGO:04810510.5VANGL2, CELSR1
5astrocyte cell migrationGO:04361510.5SCRIB, CCL2
6mammary gland duct morphogenesisGO:06060310.4SCRIB, PTCH1
7apical protein localizationGO:04517610.3VANGL2, CELSR1
8tetrahydrofolate interconversionGO:03599910.3MTHFR, MTHFD1
9establishment of planar polarityGO:00173610.3CELSR1, VANGL2, FUZ
10wound healingGO:04206010.3CELSR1, VANGL2, SCRIB
11planar cell polarity pathway involved in neural tube closureGO:09017910.3CELSR1, VANGL2
12hair follicle developmentGO:00194210.2CELSR1, VANGL2, FUZ
13protein methylationGO:00647910.2BHMT, PCMT1
14heart morphogenesisGO:00300710.2T, PTCH1, ALDH1A2
15anterior/posterior pattern specificationGO:00995210.2ALDH1A2, CELSR1, VANGL2
16SMAD protein signal transductionGO:06039510.2AFP, T
17regulation of actin cytoskeleton organizationGO:03295610.2CELSR1, VANGL2
18post-anal tail morphogenesisGO:03634210.1T, VANGL2
19regulation of smoothened signaling pathwayGO:00858910.1FUZ, PTCH1, ZIC1
20water-soluble vitamin metabolic processGO:00676710.0MTHFD1, MTHFR, MTRR
21vitamin metabolic processGO:00676610.0MTRR, MTHFR, MTHFD1
22methionine biosynthetic processGO:0090869.9MTHFD1, MTHFR, MTRR, BHMT
23folic acid metabolic processGO:0466559.9FOLR1, MTHFD1, MTHFR, MTRR
24sulfur amino acid metabolic processGO:0000969.7BHMT, MTRR
25brain developmentGO:0074209.5ZIC2, ZIC1, PTCH1
26neural tube closureGO:0018439.4ZIC2, CELSR1, VANGL2, PTCH1, SCRIB, T

Products for genes affiliated with Spina Bifida

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Sources for Spina Bifida

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4CDC
14ExPASy
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23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
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42NDF-RT
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