MCID: SPN038
MIFTS: 68

Spina Bifida malady

Genetic diseases, Rare diseases, Neuronal diseases categories
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Summaries for Spina Bifida

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NINDS:43 Spina bifida (SB) is a neural tube defect (a disorder involving incomplete development of the brain, spinal cord, and/or their protective coverings) caused by the failure of the fetus's spine to close properly during the first month of pregnancy. Infants born with SB sometimes have an open lesion on their spine where significant damage to the nerves and spinal cord has occurred. Although the spinal opening can be surgically repaired shortly after birth, the nerve damage is permanent, resulting in varying degrees of paralysis of the lower limbs. Even when there is no lesion present there may be improperly formed or missing vertebrae and accompanying nerve damage. In addition to physical and mobility difficulties, most individuals have some form of learning disability. The types of SB are: myelomeningocele, the severest form, in which the spinal cord and its protective covering (the meninges) protrude from an opening in the spine; meningocele in which the spinal cord develops normally but the meninges and spinal fluid) protrude from a spinal opening; closed neural tube defects, which consist of a group of defects in which development of the spinal cord is affected by malformations of the fat, bone, or meninges; and and occulta, the mildest form, in which one or more vertebrae are malformed and covered by a layer of skin. SB may also cause bowel and bladder complications, and many children with SB have hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain).

MalaCards based summary: Spina Bifida, also known as spinal dysraphism, is related to spina bifida occulta and anencephaly. An important gene associated with Spina Bifida is CCL2 (chemokine (C-C motif) ligand 2), and among its related pathways are Folate Metabolism and Wnt / Hedgehog / Notch. The compounds ch2h4folate and "vitamin b-complex, plain" have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are other and pigmentation.

Genetics Home Reference:21 Spina bifida is a condition in which the neural tube, a layer of cells that ultimately develops into the brain and spinal cord, fails to close completely during the first few weeks of embryonic development. As a result, when the spine forms, the bones of the spinal column do not close completely around the developing nerves of the spinal cord. Part of the spinal cord may stick out through an opening in the spine, leading to permanent nerve damage. Because spina bifida is caused by abnormalities of the neural tube, it is classified as a neural tube defect.

NIH Rare Diseases:42 Spina bifida is a type of neural tube defect in which the bones of the spinal column do not close completely around the developing nerves of the spinal cord during the development of the embryo. as a result, part of the spinal cord may stick out through an opening in the spine, leading to permanent nerve damage. children born with spina bifida often have a fluid-filled sac on their back covered by skin. if the sac contains part of the spinal cord and its protective covering, it is known as a myelomeningocele; if it does not, it is known as a meningocele. the signs and symptoms range from mild to severe (depending on the location and extent of spinal cord involvement) and can include a loss of feeling below the level of the opening; weakness or paralysis of the feet or legs; problems with bladder and bowel control; hydrocephalus; and learning problems. with surgery and other forms of treatment, many people with spina bifida live into adulthood. there is also a milder form of the condition called spina bifida occulta. last updated: 5/9/2011

MedlinePlus:33 Spina bifida is a neural tube defect - a type of birth defect of the brain, spine, or spinal cord. it happens if the spinal column of the fetus doesn't close completely during the first month of pregnancy. this can damage the nerves and spinal cord. screening tests during pregnancy can check for spina bifida. sometimes it is discovered only after the baby is born. the symptoms of spina bifida vary from person to person. most people with spina bifida are of normal intelligence. some people need assistive devices such as braces, crutches, or wheelchairs. they may have learning difficulties, urinary and bowel problems, or hydrocephalus, a buildup of fluid in the brain. the exact cause of spina bifida is unknown. it seems to run in families. taking folic acid can reduce the risk of having a baby with spina bifida. it's in most multivitamins. women who could become pregnant should take it daily. nih: national institute of neurological disorders and stroke

Wikipedia:65 Spina bifida (Latin: \"split spine\") is a developmental congenital disorder caused by the incomplete... more...

Description from OMIM:46 182940

Aliases & Classifications for Spina Bifida

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Spina Bifida, Aliases & Descriptions:

Name: Spina Bifida 30 8 42 21 43 46 10 44 33
Spinal Dysraphism 42 21
Rachischisis 42 21
 
Cleft Spine 42 21
Open Spine 42 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:0080016
ICD1025 Q05, Q05.4

Related Diseases for Spina Bifida

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Diseases related to Spina Bifida via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1spina bifida occulta32.7PTCH1
2anencephaly32.4AFP, MTHFR, FOLR1
3neural tube defects32.0T, MTHFR
4caudal regression syndrome31.4VANGL1
5craniorachischisis31.1VANGL2
6strabismus30.9VANGL2
7holoprosencephaly30.7ZIC1, PTCH1, ZIC2
8down syndrome30.6MTHFR, MTRR, AFP
9vascular disease30.4BHMT, MTHFR, CCL2, MTRR
10occult spinal dysraphism11.2
11spina bifida aperta11.1
12myelomeningocele11.0
13hydrocephalus10.9
14myelocystocele10.8
15posterior meningocele10.8
16cerebritis10.7
17meningocele10.7
18neurogenic bladder10.6
19split hand urinary anomalies spina bifida10.6
20cervicitis10.6
21encephalocele10.6
22cerebral palsy10.5
23spinal cord injury10.5
24anencephaly and spina bifida x-linked10.5
25spina bifida hypospadias10.5
26cystic lymphangioma10.5AFP
27spondylolisthesis10.5
28homocysteinemia10.5MTHFR
29lobar holoprosencephaly10.5PTCH1
30portal vein thrombosis10.5AFP, MTHFR
31gastroschisis10.5AFP
32fecal incontinence10.4
33obesity10.4
34spondylolysis10.4
35constipation10.4
36chiari malformation10.4
37kasznica carlson coppedge syndrome10.4
38patau syndrome10.4AFP, ZIC2
39megaloblastic anemia10.4DHFR
40placental abruption10.4MTHFR, AFP
41hypertension10.4
42neurogenic bowel10.4
43neuronitis10.4
44orofacial cleft10.4
45chiari malformation type 210.4
46exencephaly10.4
47mental retardation10.4
48cervical spina bifida cystica10.4
49lumbosacral spina bifida cystica10.4
50upper thoracic spina bifida aperta10.4

Graphical network of the top 20 diseases related to Spina Bifida:



Diseases related to spina bifida

Symptoms for Spina Bifida

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Clinical features from OMIM:

182940

Drugs & Therapeutics for Spina Bifida

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Drug clinical trials:

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Genetic Tests for Spina Bifida

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Anatomical Context for Spina Bifida

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MalaCards organs/tissues related to Spina Bifida:

32
Spinal cord, Brain, Bone, Skin, Testes, Colon, Kidney, Heart, Cerebellum, Bone marrow, Lung, Breast, Endothelial, Temporal lobe, Dorsal root ganglion, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Spina Bifida:
id TissueAnatomical CompartmentCell Relevance
1 Neural TubeNeural Tube  Affected by disease

Animal Models for Spina Bifida or affiliated genes

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MGI Mouse Phenotypes related to Spina Bifida:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.9PTCH1, MTHFD1, CELSR1, VANGL2
2MP:00011869.8CCL2, FUZ, PTCH1, ZIC2
3MP:00053779.6VANGL1, FUZ, ALDH1A2, FOLR1, VANGL2, CELSR1
4MP:00020069.5PTCH1, SCRIB, AFP, CCL2, BHMT, FOLR1
5MP:00053699.5ALDH1A2, ZIC1, CCL2, PTCH1, FUZ, PCMT1
6MP:00053889.5FUZ, ALDH1A2, VANGL1, PCMT1, CELSR1, VANGL2
7MP:00053679.4VANGL2, SCRIB, T, DACT1, PTCH1, BHMT
8MP:00053799.4ALDH1A2, FOLR1, PTCH1, SCRIB, AFP, FUZ
9MP:00053819.4FOLR1, VANGL2, PTCH1, SCRIB, T, FUZ
10MP:00053979.3CELSR1, PTCH1, ALDH1A2, CCL2, MTHFD1, PCMT1
11MP:00053919.2SCRIB, PTCH1, FOLR1, ALDH1A2, MTHFR, CCL2
12MP:00107719.2CCL2, ZIC2, MTHFR, CELSR1, PTCH1, T
13MP:00053899.2AFP, T, DACT1, MTHFR, PTCH1, VANGL2
14MP:00028739.2VANGL1, ALDH1A2, VANGL2, CCL2, PTCH1, T
15MP:00053829.2VANGL2, PTCH1, T, FUZ, CELSR1, FOLR1
16MP:00053859.0CCL2, ZIC2, PTCH1, VANGL2, FUZ, VANGL1
17MP:00053869.0T, PCMT1, ZIC2, ZIC1, CCL2, PTCH1
18MP:00053718.7CELSR1, DACT1, ALDH1A2, ZIC2, MTHFR, MTHFD1
19MP:00053808.7SCRIB, T, DACT1, FOLR1, CELSR1, PTCH1
20MP:00053908.6DACT1, ZIC1, FUZ, T, PTCH1, VANGL2
21MP:00053768.4CCL2, CELSR1, VANGL2, AFP, T, FUZ
22MP:00036317.9SCRIB, T, VANGL1, CELSR1, DACT1, VANGL2
23MP:00053787.8BHMT, DACT1, T, SCRIB, VANGL2, PTCH1
24MP:00107687.7ZIC1, VANGL2, FOLR1, MTHFD1, MTHFR, ZIC2

Publications for Spina Bifida

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Articles related to Spina Bifida:

(show top 50)    (show all 1015)
idTitleAuthorsYear
1
Health-related quality of life is compromised in individuals with spina bifida: results from qualitative and quantitative studies. (25171266)
2014
2
Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome. (24891102)
2014
3
Fetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experience. (24299030)
2014
4
Exploration of internet use: profile and preferences of transition-aged adolescents with spina bifida. (25269357)
2014
5
DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects. (25131656)
2014
6
Left-sided Poland's syndrome in a girl with rare associations like spina bifida and diaphragmatic hernia. (24057335)
2013
7
Evidence for spatial navigational impairments in hydrocephalus patients without spina bifida. (23959082)
2013
8
Neural activity generated in the neural placode and nerve roots in the neonate with spina bifida. (22462714)
2012
9
Letter to the editor: Spina bifida and neuropsychology. (22546037)
2012
10
Distribution of affected muscles and degree of neurogenic lesion in patients with spina bifida. (22328890)
2011
11
Early infantile electroencephalography in patients with spina bifida*. (21800274)
2011
12
Computer-mediated support for adolescents with cerebral palsy or spina bifida. (21099541)
2011
13
Bladder augmentation versus urinary diversion in patients with spina bifida in the United States. (21575969)
2011
14
Sensory tract abnormality in the chick model of spina bifida. (21658418)
2011
15
Detecting open spina bifida at the 11-13-week scan by assessing intracranial translucency and the posterior brain region: mid-sagittal or axial plane? (22411445)
2011
16
The urologist's role in the management of spina bifida: a continuum of care. (20350747)
2010
17
Orthopedic management of spina bifida. (20419777)
2010
18
Inferential ability in children with cerebral palsy, spina bifida and pragmatic language impairment. (19800759)
2010
19
The role of the retrograde colonic enema in children with spina bifida: is it inferior to the antegrade continence enema? (20198477)
2010
20
Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida. (19683694)
2009
21
The experience of self-management in adolescent women with spina bifida. (19160922)
2009
22
Role of prenatal ultrasound in predicting survival and mental and motor functioning in children with spina bifida. (19670337)
2009
23
Spatial cognition and motor development: a study of children with spina bifida. (18556900)
2008
24
Bio-monitoring the elimination of folic acid-preventable spina bifida and anencephaly. (18585451)
2008
25
GDNF plasma levels in spina bifida: correlation with severity of spinal damage and motor function. (19125682)
2008
26
Interpreting changes in the epidemiology of anencephaly and spina bifida following folic acid fortification of the U.S. grain supply in the setting of long-term trends, Atlanta, Georgia, 1968-2003. (17990332)
2007
27
Natural rubber latex sensitisation and allergy in patients with spina bifida, urogenital disorders and oesophageal atresia compared with a normal paediatric population. (17638159)
2007
28
Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida. (16523512)
2006
29
Evaluation of sexual function in young men with spina bifida and myelomeningocele using the International Index of Erectile Function. (16504267)
2006
30
Rehabilitating the neurogenic bladder: the role of artificial neural reflex pathways in children with spina bifida. (16526998)
2006
31
Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus. (15039923)
2004
32
Spina bifida occulta as a relative contraindication for percutaneous retrograde lead insertion for sacral nerve root stimulation. (22151780)
2002
33
The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy. (9863598)
1998
34
Neurological dysfunction above cele level in children with spina bifida cystica. (9926334)
1998
35
Spinal hematoma following spinal anesthesia in a patient with spina bifida occulta. (9357903)
1997
36
Congenital talipes equinovarus in spina bifida: treatment and results. (8906652)
1996
37
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. (1283633)
1992
38
Prevalence of spina bifida occulta in patients with functional disorders of the lower urinary tract and its relation to urodynamic and neurophysiological measurements. (2493933)
1989
39
Neurophysiological measurements in patients with genuine stress incontinence of urine and the relation of neurogenic defects to the presence of spina bifida occulta. (3044478)
1988
40
Investigation of a cluster of anencephaly and spina bifida. (6383023)
1984
41
Factors affecting the ambulatory status of patients with spina bifida cystica. (6600743)
1983
42
Comparison of alphafetoprotein and beta-trace protein in the antenatal diagnosis of anencephaly and spina bifida. (57018)
1976
43
Amniotic fluid alpha2-macroglobulin and the antenatal diagnosis of spina bifida and anencephaly. (52422)
1975
44
The renal tract in spina bifida cystica. (4569783)
1972
45
Neuroschisis and human embryonic maldevelopment. New evidence on anencephaly, spina bifida and diverse mammalian defects. (4985177)
1970
46
The long-term evaluation of a trial of immediate and delayed closure of spina bifida cystica. (5339471)
1967
47
THE NATURAL HISTORY OF SPINA BIFIDA CYSTICA: DETAILED ANALYSIS OF 407 CASES. (14160086)
1964
48
Incidence of spina bifida occulta in relation to age. (13301135)
1956
49
Late neurologic symptoms of spina bifida occulta: report of case. (13297807)
1956
50
II. Cases of Operation in Spina Bifida and Encephalocele. (17859817)
1892

Variations for Spina Bifida

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UniProtKB/Swiss-Prot genetic disease variations for Spina Bifida:

64 (show all 12)
id Symbol AA change Variation ID SNP ID
1CELSR1p.Ala773ValVAR_067213rs12170597
2CELSR1p.Arg2438GlnVAR_067215rs199688538
3CELSR1p.Ser2964LeuVAR_067217rs6008777
4CELSR1p.Pro2983AlaVAR_067218rs61741871
5DACT1p.Asn356LysVAR_068429
6SCRIBp.Pro454SerVAR_067219
7SCRIBp.Arg1535GlnVAR_067220
8VANGL1p.Arg274GlnVAR_035210
9VANGL1p.Met328ThrVAR_035211
10VANGL2p.Ser84PheVAR_067221
11VANGL2p.Arg353CysVAR_067222
12VANGL2p.Phe437SerVAR_067223

Clinvar genetic disease variations for Spina Bifida:

6
id Gene Name Type Significance SNP ID Assembly Location
1VANGL1NM_138959.2(VANGL1): c.821G> A (p.Arg274Gln)single nucleotide variantPathogenicrs121918219GRCh37Chr 1, 116224993: 116224993
2VANGL1NM_138959.2(VANGL1): c.983T> C (p.Met328Thr)single nucleotide variantPathogenicrs121918220GRCh37Chr 1, 116226601: 116226601
3FUZNM_025129.4(FUZ): c.115C> T (p.Pro39Ser)single nucleotide variantPathogenicrs387907204GRCh37Chr 19, 50315990: 50315990
4FUZNM_025129.4(FUZ): c.1060G> T (p.Asp354Tyr)single nucleotide variantPathogenicrs139365610GRCh37Chr 19, 50310605: 50310605
5FUZFUZZY, ARG404GLUsingle nucleotide variantPathogenic
6VANGL2NM_020335.2(VANGL2): c.1057C> T (p.Arg353Cys)single nucleotide variantPathogenicrs267607167GRCh37Chr 1, 160390961: 160390961
7VANGL2NM_020335.2(VANGL2): c.1310T> C (p.Phe437Ser)single nucleotide variantPathogenicrs267607168GRCh37Chr 1, 160394912: 160394912

Expression for genes affiliated with Spina Bifida

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Expression patterns in normal tissues for genes affiliated with Spina Bifida

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Pathways for genes affiliated with Spina Bifida

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Pathways related to Spina Bifida according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism37
10.0MTRR, MTHFR
29.8PTCH1, SCRIB, AFP, T
3
Show member pathways
flavin biosynthesis IV (mammalian)37
molybdenum cofactor biosynthesis37
coenzyme A biosynthesis37
thiamin salvage III37
alanine biosynthesis III37
thio-molybdenum cofactor biosynthesis37
biotin-carboxyl carrier protein assembly37
9.6MTRR, DHFR, MTHFD1, MTHFR
4
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.4MTHFD1, DHFR, MTHFR, BHMT, MTRR

Compounds for genes affiliated with Spina Bifida

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Compounds related to Spina Bifida according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4410.5MTHFD1, MTHFR
2vitamin b-complex, plain5010.4MTRR, MTHFR
35,10-methenyltetrahydrofolate4410.4MTHFD1, MTHFR
45,10-Methylene-THF2410.4MTHFD1, MTHFR
5methylcobalamin44 2411.4MTHFR, MTRR
6b vitamins4410.4MTHFR, MTRR
7multivitamin4410.3DHFR, MTHFR
8pemetrexed50 1111.3DHFR, MTHFR
9hydroxocobalamin44 1111.3MTHFR, MTRR
10cyanocobalamin50 24 1112.3MTRR, MTHFR
11trimetrexate44 1111.3DHFR, FOLR1
12cobalamin44 2411.3MTHFR, MTHFD1, MTRR
1310-formyltetrahydrofolate4410.3MTHFD1, DHFR, MTHFR
14vitamin b64410.3BHMT, MTHFD1, MTHFR
15Tetrahydrofolic acid24 1111.2MTHFD1, DHFR, MTHFR
165-methyltetrahydrofolate44 1111.2MTRR, FOLR1, MTHFR
17betaine44 2411.2MTRR, BHMT, MTHFR
18riboflavin44 24 1112.2MTHFR, MTRR, BHMT
19s-adenosylhomocysteine44 2411.2PCMT1, MTHFR, MTRR
20tetrahydrofolate4410.2MTRR, MTHFR, DHFR
21bleomycin44 1111.2AFP, CCL2, DHFR
22L-Methionine24 1111.2MTRR, BHMT
23tomudex4410.2DHFR, FOLR1
24dihydrofolate4410.1FOLR1, MTHFR, DHFR
25leucovorin44 50 1112.1FOLR1, DHFR, MTHFR
26cyclophosphamide44 50 1112.1MTHFR, CCL2, AFP, DHFR
27methylmalonic acid44 2411.1MTRR, MTHFR
28cystathionine4410.1BHMT, MTRR, MTHFR, MTHFD1
295fluorouracil4410.1MTHFR, CCL2, AFP, DHFR
30acyclovir44 1111.0DHFR, AFP
31purine44 2411.0MTHFD1, MTHFR, DHFR
32s-adenosylmethionine44 24 1112.0MTRR, MTHFR, PCMT1, BHMT
33folic acid50 24 1112.0DHFR, MTRR, MTHFR, FOLR1
34vitamin b124410.0BHMT, MTRR, MTHFR, CCL2, AFP
35NADP2410.0MTRR, MTHFR, MTHFD1, DHFR
36nadh44 24 1111.9MTHFR, MTHFD1, DHFR, ALDH1A2
37cisplatin44 50 61 1112.9AFP, DHFR, CCL2, MTHFR, FOLR1
38valine449.8AFP, DHFR, MTHFR
39nadph44 2410.8MTRR, MTHFD1, CCL2, DHFR, MTHFR
40methionine449.8FOLR1, MTRR, MTHFR, BHMT, MTHFD1
41thymidylate449.8MTHFR, DHFR, MTRR, MTHFD1, FOLR1
42carbon449.7MTHFR, DHFR, AFP
43homocysteine44 2410.7MTRR, BHMT, FOLR1, CCL2, MTHFR, MTHFD1
44aspartate449.7PCMT1, MTHFR, DHFR, MTRR, AFP, CCL2
45methotrexate50 44 1111.6DHFR, AFP, MTRR, MTHFR, MTHFD1, FOLR1
46FAD249.6MTRR, ALDH1A2, MTHFR
47zinc44 2410.5BHMT, ZIC2, ZIC1, AFP, PTCH1
48alanine449.5MTRR, ZIC2, DHFR, AFP, MTHFR
49folate449.4FOLR1, BHMT, MTRR, AFP, DHFR, MTHFD1
50serine449.2CCL2, BHMT, FOLR1, DHFR, MTHFD1, MTRR

GO Terms for genes affiliated with Spina Bifida

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Cellular components related to Spina Bifida according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.3BHMT, FUZ, T, AFP, CCL2, MTRR

Biological processes related to Spina Bifida according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1establishment of body hair planar orientationGO:04810510.5CELSR1, VANGL2
2lateral sprouting involved in lung morphogenesisGO:06049010.5VANGL2, CELSR1
3orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048810.5VANGL2, CELSR1
4planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048910.5VANGL2, CELSR1
5astrocyte cell migrationGO:04361510.5CCL2, SCRIB
6mammary gland duct morphogenesisGO:06060310.4SCRIB, PTCH1
7establishment of planar polarityGO:00173610.4FUZ, VANGL2, CELSR1
8apical protein localizationGO:04517610.4VANGL2, CELSR1
9tetrahydrofolate interconversionGO:03599910.3MTHFR, MTHFD1
10hair follicle developmentGO:00194210.3FUZ, VANGL2, CELSR1
11wound healingGO:04206010.3SCRIB, CELSR1, VANGL2
12planar cell polarity pathway involved in neural tube closureGO:09017910.3CELSR1, VANGL2
13protein methylationGO:00647910.2PCMT1, BHMT
14heart morphogenesisGO:00300710.2PTCH1, ALDH1A2, T
15anterior/posterior pattern specificationGO:00995210.2VANGL2, CELSR1, ALDH1A2
16regulation of smoothened signaling pathwayGO:00858910.2FUZ, PTCH1, ZIC1
17SMAD protein signal transductionGO:06039510.2AFP, T
18regulation of actin cytoskeleton organizationGO:03295610.2VANGL2, CELSR1
19post-anal tail morphogenesisGO:03634210.1VANGL2, T
20water-soluble vitamin metabolic processGO:00676710.1MTRR, MTHFR, MTHFD1
21vitamin metabolic processGO:00676610.1MTHFR, MTRR, MTHFD1
22methionine biosynthetic processGO:00908610.0MTHFR, MTRR, BHMT, MTHFD1
23folic acid metabolic processGO:04665510.0MTHFD1, FOLR1, MTHFR, MTRR
24sulfur amino acid metabolic processGO:0000969.7MTRR, BHMT
25brain developmentGO:0074209.6ZIC2, ZIC1, PTCH1
26neural tube closureGO:0018439.6PTCH1, FUZ, T, SCRIB, VANGL2, CELSR1

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