MCID: SPN038
MIFTS: 70

Spina Bifida malady

Neuronal diseases category

Summaries for Spina Bifida

About this section
Sources:
42NIH Rare Diseases, 33MedlinePlus, 3CDC, 43NINDS, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:43 Spina bifida (SB) is a neural tube defect (a disorder involving incomplete development of the brain, spinal cord, and/or their protective coverings) caused by the failure of the fetus's spine to close properly during the first month of pregnancy. Infants born with SB sometimes have an open lesion on their spine where significant damage to the nerves and spinal cord has occurred. Although the spinal opening can be surgically repaired shortly after birth, the nerve damage is permanent, resulting in varying degrees of paralysis of the lower limbs. Even when there is no lesion present there may be improperly formed or missing vertebrae and accompanying nerve damage. In addition to physical and mobility difficulties, most individuals have some form of learning disability. The types of SB are: myelomeningocele, the severest form, in which the spinal cord and its protective covering (the meninges) protrude from an opening in the spine; meningocele in which the spinal cord develops normally but the meninges and spinal fluid) protrude from a spinal opening; closed neural tube defects, which consist of a group of defects in which development of the spinal cord is affected by malformations of the fat, bone, or meninges; and and occulta, the mildest form, in which one or more vertebrae are malformed and covered by a layer of skin. SB may also cause bowel and bladder complications, and many children with SB have hydrocephalus (excessive accumulation of cerebrospinal fluid in the brain).

MalaCards: Spina Bifida, also known as spinal dysraphism, is related to neural tube defects and myelomeningocele. An important gene associated with Spina Bifida is CCL2 (chemokine (C-C motif) ligand 2), and among its related pathways are One Carbon Metabolism and Metabolism of vitamins and cofactors. The compounds folate and homocysteine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related mouse phenotypes are mortality/aging and growth/size.

NIH Rare Diseases:42 Spina bifida is a type of neural tube defect in which the bones of the spinal column do not close completely around the developing nerves of the spinal cord during the development of the embryo. as a result, part of the spinal cord may stick out through an opening in the spine, leading to permanent nerve damage. children born with spina bifida often have a fluid-filled sac on their back covered by skin. if the sac contains part of the spinal cord and its protective covering, it is known as a myelomeningocele; if it does not, it is known as a meningocele. the signs and symptoms range from mild to severe (depending on the location and extent of spinal cord involvement) and can include a loss of feeling below the level of the opening; weakness or paralysis of the feet or legs; problems with bladder and bowel control; hydrocephalus; and learning problems. with surgery and other forms of treatment, many people with spina bifida live into adulthood. there is also a milder form of the condition called spina bifida occulta. last updated: 5/9/2011

MedlinePlus:33 Spina bifida is a neural tube defect - a type of birth defect of the brain, spine, or spinal cord. it happens if the spinal column of the fetus doesn't close completely during the first month of pregnancy. this can damage the nerves and spinal cord. screening tests during pregnancy can check for spina bifida. sometimes it is discovered only after the baby is born. the symptoms of spina bifida vary from person to person. most people with spina bifida are of normal intelligence. some people need assistive devices such as braces, crutches, or wheelchairs. they may have learning difficulties, urinary and bowel problems, or hydrocephalus, a buildup of fluid in the brain. the exact cause of spina bifida is unknown. it seems to run in families. taking folic acid can reduce the risk of having a baby with spina bifida. it's in most multivitamins. women who could become pregnant should take it daily. nih: national institute of neurological disorders and stroke

CDC:3 Spina bifida is a major birth defect of a person’s spine. With good quality medical care people with spina bifida can reach their full potential. If you have spina bifida, or know someone who does, it’s important to get the facts so that you can make the best possible health care choices.

Genetics Home Reference:21 Spina bifida is a condition in which the bones of the spinal column do not close completely around the developing nerves of the spinal cord. As a result, part of the spinal cord may stick out through an opening in the spine, leading to permanent nerve damage. Spina bifida results when a structure called the neural tube fails to close completely during the first few weeks of embryonic development. The neural tube is a layer of cells that ultimately develops into the brain and spinal cord. Because spina bifida is caused by abnormalities of the neural tube, it is classified as a neural tube defect (NTD).

Wikipedia:63 Spina bifida (Latin: \"split spine\") is a developmental congenital disorder caused by the incomplete... more...

Description from OMIM:46 182940

Aliases & Classifications for Spina Bifida

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spina bifida 8 42 21 43 46 10 44 33
spinal dysraphism 42 21
rachischisis 42 21
cleft spine 42 21
open spine 42 21


External Ids:

Disease Ontology8 DOID:0080016
ICD1025 Q05, Q05.4

Related Diseases for Spina Bifida

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spina Bifida via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1neural tube defects31.2T, MTHFR
2myelomeningocele31.2CBS, MTHFR
3cleft palate30.6MTHFR, SLC19A1, MTR
4hypertension30.5MTHFR, CCL2
5cleft lip30.4MTR, SLC19A1, MTHFR, MTRR
6congenital heart defect30.3MTHFR
7craniorachischisis30.3VANGL2
8strabismus30.3VANGL2
9down syndrome30.1MTR, MTHFR, MTRR, AFP, CBS, SLC19A1
10breast cancer30.1MTRR, SLC19A1, FOLR1, MTHFR, DHFR, CBS
11adenocarcinoma30.1AFP, FOLR1
12vascular disease30.1CBS
13schizophrenia30.1MTHFR
14rheumatoid arthritis30.1MTHFR, DHFR, CCL2, SLC19A1
15arthritis30.1CCL2
16diabetes mellitus30.1MTHFR, CCL2
17hydrocephalus10.8
18spina bifida cystica10.8
19spina bifida aperta10.8
20myelocystocele10.7
21posterior meningocele10.7
22cerebritis10.6
23meningocele10.6
24neurogenic bladder10.6
25split hand urinary anomalies spina bifida10.6
26occult spinal dysraphism10.6
27cervicitis10.5
28spina bifida occulta10.5
29cerebral palsy10.5
30spina bifida hypospadias10.5
31tethered spinal cord syndrome10.5
32anencephaly and spina bifida x-linked10.4
33fecal incontinence10.4
34spondylolisthesis10.4
35constipation10.4
36obesity10.4
37neuronitis10.3
38orofacial cleft10.3
39chiari malformation type 210.3
40caudal regression syndrome10.3
41kasznica carlson coppedge syndrome10.3
42iniencephaly10.3
43upper thoracic spina bifida aperta10.3
44cervical spina bifida aperta10.3
45bacteriuria10.2
46syringomyelia10.2
47tuberous sclerosis10.2
48neurogenic bowel10.2
49digeorge syndrome10.2
50spondylolysis10.2

Graphical network of the top 20 diseases related to Spina Bifida:



Diseases related to spina bifida

Clinical Features for Spina Bifida

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

182940

Drugs & Therapeutics for Spina Bifida

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spina Bifida

Drug clinical trials:

Search ClinicalTrials for Spina Bifida

Search NIH Clinical Center for Spina Bifida

Search CenterWatch for Spina Bifida

Genetic Tests for Spina Bifida

About this section

Anatomical Context for Spina Bifida

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Spina Bifida:

32
Spinal cord, Brain, Bone, Skin, Testes, Kidney, Colon, Heart, Cerebellum, Dorsal root ganglion, Temporal lobe, Bone marrow, Endothelial, Breast, Lung, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Spina Bifida:
id TissueAnatomical CompartmentCell Relevance
1 Neural TubeNeural Tube  Affected by disease

Animal Models for Spina Bifida or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Spina Bifida

About this section
Sources:
50PubMed
See all sources

Articles related to Spina Bifida:

(show top 50)    (show all 1000)
idTitleAuthorsYear
1
Lumbo-sacral malformations and spina bifida occulta in medieval skeletons from Brittany. (23412445)
2013
2
Urolithiasis in adult spina bifida patients: study in 260 patients and discussion of the literature. (23604705)
2013
3
Youth and Young Adults With Spina Bifida: Their Utilization of Physician and Hospital Services. (24095657)
2013
4
Editorial comment to spina bifida occulta: not to be overlooked in children with nocturnal enuresis. (23380002)
2013
5
Individual adjustment, parental functioning, and perceived social support in Hispanic and non-Hispanic white mothers and fathers of children with spina bifida. (21990583)
2012
6
Strabismus in spina bifida myelomeningocele. (22998448)
2012
7
Visual assessment of segmental muscle ultrasound images in spina bifida aperta. (22698513)
2012
8
Sexuality, pre-conception counseling and urological management of pregnancy for young women with spina bifida. (22546496)
2012
9
Sacral nerve modulation for defaecation and micturition disorders in patients with spina bifida. (21689346)
2012
10
Hospital use, associated costs, and payer status for infants born with spina bifida. (23115108)
2012
11
The role of amino acids in spina bifida. (23157048)
2012
12
Quality of life of very young spina bifida patients after initial surgical treatment. (22249383)
2012
13
Antibiotic prophylaxis for urinary tract infections in children with spina bifida on intermittent catheterization. (22019031)
2011
14
Laparoscopic hysteropexy in a patient with spina bifida and ventriculoperitoneal shunt. (21902988)
2011
15
Congenital absent cervical spine pedicle and cervical spina bifida occulta. (21145528)
2010
16
Cerebellar motor function in spina bifida meningomyelocele. (20652468)
2010
17
Timing of ventriculoperitoneal shunt insertion following spina bifida closure in Kenya. (20422197)
2010
18
Re: The significance of 99mtechnetium dimercapto-succinic acid renal scan in children with spina bifida during long-term follow-up: Y. Shiroyanagi, M. Suzuki, D. Matsuno and Y. Yamazaki J Urol 2009; 181: 2262-2266. (19945126)
2010
19
54th annual meeting of the society for research into hydrocephalus and spina bifida vancouver, Canada. 7-10 july 2010. Abstracts. (21266023)
2010
20
Strong-meter and weak-meter rhythm identification in spina bifida meningomyelocele and volumetric parcellation of rhythm-relevant cerebellar regions. (19673758)
2009
21
Neuropsychological assessment of attention in children with spina bifida. (19476646)
2009
22
Urinary tract infections in children with spina bifida: an inventory of 41 European centers. (19066975)
2009
23
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. (19223390)
2009
24
Racial/ethnic differences in the birth prevalence of spina bifida - United States, 1995-2005. (19129744)
2009
25
Robotic-assisted laparoscopic mitrofanoff appendicovesicostomy and antegrade continent enema colon tube creation in a pediatric spina bifida patient. (18373465)
2008
26
Barriers to community participation: Teens and young adults with spina bifida. (21791783)
2008
27
Bacteriuria management and urological evaluation of patients with spina bifida and neurogenic bladder: a multicenter survey. (15592079)
2005
28
Augmentation ileocystoplasty in patients with neurogenic bladder due to spinal cord injury or spina bifida. (11821967)
2002
29
Comparison of national policies on periconceptional use of folic acid to prevent spina bifida and anencephaly (SBA). (9143094)
1997
30
Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis--United States, 1985-1994. (7637675)
1995
31
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. (1283633)
1992
32
Neurological defects of the voiding reflex arcs in chronic urinary retention and their relation to spina bifida occulta. (2645967)
1989
33
Closure of large spina bifida cystica defects with bilateral bipedicled musculocutaneous flaps. (6364193)
1984
34
Mal perforans and spina bifida occulta. (24425)
1978
35
Nursing care study: spina bifida cystica. (323821)
1977
36
Handicap and social status of adults with spina bifida cystica. (4604518)
1974
37
Prenatal diagnosis of spina bifida and anencephaly through maternal plasma-alpha-fetoprotein measurement. (4132706)
1974
38
Perinatal infections and epidemiology of anencephaly and spina bifida. (4358489)
1973
39
Spina bifida, anencephaly, and potato blight. (4119734)
1973
40
Lumbo-sacral malformations and spina bifida occulta in a group of proto-historic Modoc Indians. (4556230)
1972
41
Spina bifida, anencephaly, and potato blight. (4117831)
1972
42
Incidence of spina bifida occulta in Andhra area in India. (4566430)
1972
43
A new look at spina bifida aperta. (4937368)
1971
44
Anencephaly and spina bifida in the Province of Quebec. (4888983)
1969
45
Some observations on the lower urinary tract in infants with spina bifida cystica. (5326957)
1966
46
The management of spina bifida cystica. (5325657)
1966
47
THE NATURAL HISTORY OF SPINA BIFIDA CYSTICA: DETAILED ANALYSIS OF 407 CASES. (14160086)
1964
48
EFFECT OF CONTINUAL DECOMPRESSION USING HOLTER VALVE ON WEIGHTS OF CEREBRAL HEMISPHERES IN CHILDREN WITH HYDROCEPHALUS AND SPINA BIFIDA CYSTICA. (14208172)
1964
49
SPINA BIFIDA CYSTICA AND OCCULTA: SOME ASPECTS OF SPINAL DYSRAPHISM. (14201804)
1964
50
The deficiency of the processus spinosus of the thoracic vertebrae with spina bifida occulta. (15417744)
1950

Genetic Variations for Spina Bifida

About this section
Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Spina Bifida:

62 (show all 12)
id Symbol AA change Variation ID SNP ID
1CELSR1p.Ala773ValVAR_067213rs12170597
2CELSR1p.Arg2438GlnVAR_067215rs199688538
3CELSR1p.Ser2964LeuVAR_067217rs6008777
4CELSR1p.Pro2983AlaVAR_067218rs61741871
5DACT1p.Asn356LysVAR_068429
6SCRIBp.Pro454SerVAR_067219
7SCRIBp.Arg1535GlnVAR_067220
8VANGL1p.Arg274GlnVAR_035210
9VANGL1p.Met328ThrVAR_035211
10VANGL2p.Ser84PheVAR_067221
11VANGL2p.Arg353CysVAR_067222
12VANGL2p.Phe437SerVAR_067223

Expression for genes affiliated with Spina Bifida

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spina Bifida

Search GEO for disease gene expression data for Spina Bifida.

Pathways for genes affiliated with Spina Bifida

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 49PharmGKB, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Spina Bifida according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6MTRR, MTHFD1, MTHFR, MTR, BHMT, DHFR
2
Hide members
10.6MTRR, MTHFD1, MTHFR, MTR, DHFR, SLC19A1
3
Hide members
10.6DHFR, CBS, MTR, MTHFR, MTHFD1, MTRR
410.6CCL2, MTHFR, MTR, CBS
5
Hide members
10.6CBS, BHMT, MTR, MTRR
610.6CBS, BHMT, MTR, MTRR
710.6T, AFP, SCRIB
8
Hide members
10.5MTHFD1, MTHFR, MTR
9
Hide members
10.5MTHFR, MTR, CBS
10
Hide members
10.5CBS, BHMT, MTR
11
Hide members
10.5MTRR, MTR, CBS
1210.5BHMT, MTR
1310.5MTR, MTRR
1410.5DHFR, MTHFR
1510.5CBS, MTR
16
Hide members
10.5DHFR, SLC19A1

Compounds for genes affiliated with Spina Bifida

About this section
Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Spina Bifida according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1folate4411.1MTHFD1, MTRR, MTHFR, MTR, BHMT, CBS
2homocysteine44 2412.1MTHFR, CCL2, MTR, BHMT, CBS, SLC19A1
3methotrexate44 49 1113.1MTRR, MTHFD1, MTHFR, MTR, AFP, CBS
4thymidylate4411.1MTHFR, MTR, CBS, DHFR, SLC19A1, MTHFD1
5vitamin b124411.1MTRR, CBS, BHMT, AFP, CCL2, MTHFR
6methionine4411.1SLC19A1, BHMT, MTR, FOLR1, MTRR, CBS
7cystathionine4411.0CBS, BHMT, MTR, MTHFR, MTHFD1, MTRR
8s-adenosylmethionine44 11 2413.0CBS, BHMT, MTR, SLC19A1, MTRR, MTHFR
95-methyltetrahydrofolate44 1112.0MTHFR, SLC19A1, CBS, MTRR, FOLR1, MTR
1010-formyltetrahydrofolate4411.0SLC19A1, MTR, MTHFR, MTHFD1, DHFR
11betaine44 2412.0BHMT, MTR, MTHFR, MTRR, CBS
12cobalamin44 2412.0MTRR, MTHFD1, MTHFR, MTR, CBS
13tetrahydrofolate4411.0MTR, SLC19A1, DHFR, MTHFR, MTRR
14aspartate4411.0MTR, CCL2, MTRR, PCMT1, DHFR, AFP
15cisplatin44 49 59 1114.0AFP, MTR, FOLR1, MTHFR, DHFR, CCL2
16purine44 2412.0MTHFD1, MTHFR, MTR, CBS, DHFR, SLC19A1
17vitamin b64411.0CBS, BHMT, MTR, MTHFR, MTHFD1
185,10-methenyltetrahydrofolate4411.0MTHFD1, MTHFR, MTR, CBS
19dihydrofolate4411.0FOLR1, MTHFR, SLC19A1, DHFR, MTR
20s-adenosylhomocysteine44 2412.0MTRR, MTHFR, MTR, CBS, PCMT1
21b vitamins4411.0CBS, MTHFR, MTR, MTRR
22methylcobalamin44 2412.0MTHFR, MTR, MTRR, CBS
23serine4411.0CBS, BHMT, AFP, CCL2
24Tetrahydrofolic acid11 2412.0DHFR, MTR, MTHFR, MTHFD1
25methylmalonic acid44 2411.9MTR, MTRR, MTHFR, CBS
26nadph44 2411.9CCL2, MTRR, MTHFR, MTR, MTHFD1, DHFR
27folic acid49 11 2412.9SLC19A1, DHFR, MTHFR, FOLR1
28leucovorin44 49 1112.9DHFR, SLC19A1, FOLR1, MTHFR
295fluorouracil4410.9CCL2, SLC19A1, DHFR, AFP, MTHFR
30trimetrexate44 1111.9DHFR, FOLR1, SLC19A1
31cyanocobalamin49 11 2412.9MTRR, MTHFR, MTR
32hydroxocobalamin44 1111.9MTRR, MTHFR, MTR
33tomudex4410.9FOLR1, DHFR, SLC19A1
34L-Methionine11 2411.9MTRR, MTR, BHMT
35riboflavin44 11 2412.8BHMT, MTHFR, MTRR
36pt 4304410.8SLC19A1, DHFR
37methyl-group4410.8MTHFR, MTR
38ch2h4folate4410.8MTHFR, MTHFD1
39cob(ii)alamin44 2411.8MTR, MTRR
40metoprine4410.8DHFR, SLC19A1
41ag 3374410.7DHFR, SLC19A1
42ag 3314410.7SLC19A1, DHFR
43sulfasalazine44 28 49 1113.7MTHFR, CCL2, SLC19A1
44pt5234410.7DHFR, SLC19A1
45cyclophosphamide44 49 1112.7MTHFR, AFP, DHFR, CCL2
46n-hydroxysuccinimide4410.6SLC19A1, FOLR1
47ag 20344410.5DHFR, SLC19A1
48hdmtx4410.5DHFR, SLC19A1
49aicar44 11 2412.4DHFR, SLC19A1, CCL2
50carbon4410.3DHFR, MTHFR, MTR, AFP

GO Terms for genes affiliated with Spina Bifida

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Spina Bifida according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.7ALDH1A2, CCL2, MTRR, MTHFD1, MTR, AFP

Biological processes related to Spina Bifida according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1neural tube closureGO:00184311.0ZIC2, SCRIB, T, VANGL2, CELSR1
2methionine biosynthetic processGO:00908610.9BHMT, MTHFR, MTHFD1, MTRR
3water-soluble vitamin metabolic processGO:00676710.9SLC19A1, MTR, MTHFR, MTHFD1, MTRR
4vitamin metabolic processGO:00676610.9MTRR, MTHFD1, MTHFR, MTR, SLC19A1
5folic acid metabolic processGO:04665510.9FOLR1, MTHFD1, MTHFR, SLC19A1
6sulfur amino acid metabolic processGO:00009610.9MTRR, MTR, BHMT, CBS
7lateral sprouting involved in lung morphogenesisGO:06049010.9VANGL2, CELSR1
8planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048910.9VANGL2, CELSR1
9cellular nitrogen compound metabolic processGO:03464110.8MTRR, MTR, BHMT, CBS
10orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048810.8VANGL2, CELSR1
11small molecule metabolic processGO:04428110.8MTRR, MTHFD1, MTHFR, MTR, BHMT, CBS
12establishment of body hair planar orientationGO:04810510.8VANGL2, CELSR1
13wound healingGO:04206010.8SCRIB, VANGL2, CELSR1
14homocysteine metabolic processGO:05066710.8CBS, MTHFR
15tetrahydrofolate interconversionGO:03599910.8MTHFR, MTHFD1
16folic acid transportGO:01588410.8FOLR1, SLC19A1
17apical protein localizationGO:04517610.7VANGL2, CELSR1
18establishment of planar polarityGO:00173610.7VANGL2, CELSR1
19anterior/posterior pattern specificationGO:00995210.7ALDH1A2, CELSR1, VANGL2
20protein methylationGO:00647910.6PCMT1, BHMT
21planar cell polarity pathway involved in neural tube closureGO:09017910.6VANGL2, CELSR1
22methylationGO:03225910.5MTRR, MTR
23cobalamin metabolic processGO:00923510.5MTR, MTRR
24SMAD protein signal transductionGO:06039510.4T, AFP
25post-anal tail morphogenesisGO:03634210.2VANGL2, T

Molecular functions related to Spina Bifida according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:00554210.5SLC19A1, FOLR1
2homocysteine S-methyltransferase activityGO:00889810.4BHMT, MTR
3modified amino acid bindingGO:07234110.2CBS, MTHFR

Products for genes affiliated with Spina Bifida

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spina Bifida

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet