MCID: SPN040
MIFTS: 42

Spinal Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cancer

MalaCards integrated aliases for Spinal Cancer:

Name: Spinal Cancer 12 14
Spinal Cord Neoplasms 42 69
Spinal Neoplasms 42 69
Malignant Tumor of the Spinal Cord 12
Tumor of the Spinal Cord 12
Spinal Cord Neoplasm 12
Intraspinal Neoplasm 69
Spinal Cord--Cancer 69
Spinal Cord Cancer 12
Spinal Cord Tumors 51
Tumors Spinal Cord 52
Intraspinal Tumor 12
Spinal Cord Tumor 29
Spinal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5612
ICD10 33 C72.0
ICD9CM 35 192.2
NCIt 47 C3381 C3572

Summaries for Spinal Cancer

NINDS : 51 Tumors of the brain and spinal cord are abnormal growths of tissue found inside the skull or the bony spinal column.  The brain and spinal cord are the primary components of the central nervous system (CNS). Benign tumors are noncancerous, and malignant tumors are cancerous. The CNS is housed within rigid, bony quarters (i.e., the skull and spinal column), so any abnormal growth, whether benign or malignant, can place pressure on sensitive tissues and impair function. Tumors that originate in the brain or spinal cord are called primary tumors. Most primary tumors are caused by out-of-control growth among cells that surround and support neuron, specific genetic disease (such as neurofibromatosis type 1 and tuberous sclerosis), or from exposure to radiation or cancer-causing chemicals. Metastatic, or secondary, tumors in the CNS are caused by cancer cells that break away from a primary tumor located in another region of the body. Tumors can place pressure on sensitive tissues and impair function..Symptoms of brain tumors include headaches, seizures, nausea and vomiting, poor vision or hearing, changes in behavior, unclear thinking, and unsteadiness.  Spinal cord tumor symptoms include pain, numbness, and paralysis. Diagnosis is made after a neurological examination, special imaging techniques (computed tomography, and magnetic resonance imaging, positron emission tomography), laboratory tests, and a biopsy (in which a sample of tissue is taken from a suspected tumor and examined).

MalaCards based summary : Spinal Cancer, also known as spinal cord neoplasms, is related to childhood spinal cord tumor and spinal meningioma. An important gene associated with Spinal Cancer is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Pathways Affected in Adenoid Cystic Carcinoma and Regulation of Androgen receptor activity. The drugs Zoledronic acid and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotype is Increased proliferation.

Disease Ontology : 12 A central nervous system cancer that is located in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

Related Diseases for Spinal Cancer

Diseases related to Spinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 childhood spinal cord tumor 11.0
2 spinal meningioma 10.8
3 anovulation 10.6 GFAP NF2
4 basosquamous carcinoma 10.6 GFAP NF2
5 cauda equina neoplasm 10.6 GFAP NF2
6 spinal cord lymphoma 10.6
7 spinal cord glioma 10.6
8 anaplastic oligodendroglioma 10.6 GFAP NF2
9 demyelinating disease 10.6 GFAP NF2
10 benign pleural mesothelioma 10.6 GFAP NF2
11 brain stem ependymoma 10.6 GFAP NF2
12 macrocystic neurilemmoma 10.5 GFAP NF2
13 volkmann contracture 10.5 GFAP NRXN2
14 epidermolysa bullosa simplex with muscular dystrophy 10.5 GFAP NF2
15 pyoderma 10.4 GFAP SMARCE1
16 ganglioglioma 10.4 GFAP HOXB13
17 gallbladder papillary carcinoma 10.4 NF2 SMARCE1
18 spinal cord disease 10.4 HOXB13 NRXN2
19 hypoglossal nerve neoplasm 10.4 GFAP NF2
20 connective tissue cancer 10.3 GFAP NF2
21 surfactant metabolism dysfunction, pulmonary, 5 10.2 NF2 SMARCE1
22 pancoast tumor 10.2 GFAP TP53
23 brain stem astrocytic neoplasm 10.2 GFAP TP53
24 tendon sheath lipoma 10.2 GFAP TP53
25 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 GFAP TP53
26 brain glioma 10.1 GFAP TP53
27 rh isoimmunization 10.1 GFAP TP53
28 iodine hypothyroidism 10.1 GFAP TP53
29 aggressive systemic mastocytosis 10.1 GFAP TP53
30 childhood choroid plexus cancer 10.1 GFAP TP53
31 brachial plexus neuritis 10.1 GFAP TP53
32 intraductal breast myoepitheliosis 10.1 NF2 TP53
33 pineoblastoma 10.1 GFAP TP53
34 schwannoma of jugular foramen 10.1 GFAP TP53
35 gliofibroma 10.1 GFAP TP53
36 lymphopenia 10.1 GFAP TP53
37 clear cell ependymoma 10.1 GFAP HOXB13 NF2
38 prostate adenoid cystic carcinoma 10.1 GFAP TP53
39 cataract 24, anterior polar 10.1 GFAP TP53
40 central nervous system germ cell tumor 10.1 NF2 TP53
41 plasmodium ovale malaria 10.1 GFAP TP53
42 atypical choroid plexus papilloma 10.1 GFAP TP53
43 ascaridiasis 10.1 NF2 TP53
44 pacinian tumor 10.1 GFAP TP53
45 large intestine lipoma 10.1 GFAP TP53
46 melanotic medulloblastoma 10.0 GFAP TP53
47 c-p angle neurinoma 10.0 NF2 TP53
48 childhood medulloblastoma 10.0 GFAP TP53
49 vestibular disease 10.0 NF2 TP53
50 pancreatoblastoma 10.0 GFAP TP53

Graphical network of the top 20 diseases related to Spinal Cancer:



Diseases related to Spinal Cancer

Symptoms & Phenotypes for Spinal Cancer

GenomeRNAi Phenotypes related to Spinal Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 TP53

Drugs & Therapeutics for Spinal Cancer

Drugs for Spinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 438)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
2
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
3
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
5
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
6
Ifosfamide Approved Phase 4,Phase 3,Phase 1,Phase 2 3778-73-2 3690
7
Mechlorethamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-75-2 4033
8
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2180-92-9, 38396-39-3 2474
9
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 147-94-4 6253
10
Pamidronate Approved Phase 4,Phase 2 40391-99-9 4674
11
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
12
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 50-02-2 5743
14
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
15
Carboplatin Approved Phase 4,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
16
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 137-58-6 3676
17
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
18
Clonidine Approved Phase 4,Phase 2,Phase 3 4205-90-7 2803
19
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
20
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 57-27-2 5288826
21 Racepinephrine Approved Phase 4,Phase 2,Phase 3
22
Denosumab Approved Phase 4,Phase 3,Phase 2 615258-40-7
23
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
24
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
25
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
27
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 143 6006
28
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
29
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
30 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
31 Calcium, Dietary Phase 4,Phase 3,Phase 1,Phase 2
32 Diphosphonates Phase 4,Phase 2,Phase 3,Phase 1
33 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
34 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
36 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1
37 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Dermatologic Agents Phase 4,Phase 3,Phase 1,Phase 2
39 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
42 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
43 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
44 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
45 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
46 Anesthetics, General Phase 4,Phase 2,Phase 3,Phase 1
47 Anesthetics, Inhalation Phase 4
48 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
49 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Adjuvants, Anesthesia Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 435)

id Name Status NCT ID Phase Drugs
1 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
2 DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor Completed NCT00029523 Phase 4 Intrathecal (injected into the spinal fluid) DepoCyt;Intrathecal methotrexate;Intrathecal cytarabine (also known as ara-C)
3 The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast Cancer Completed NCT01907880 Phase 4 Pamidronate;Zoledronic acid;placebo
4 Study of the Efficacy of Kalinox® 170 Bar in Adult Oncology Completed NCT00646945 Phase 4 50% Oxygen/50% Nitrous oxide premix (Kalinox 170 bar);50% Oxygen/50% Nitrogen premix
5 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed NCT00745095 Phase 4 Neostigmine
6 Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression Completed NCT00634426 Phase 4
7 Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
8 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4 Dexamethasone Phosphate
9 The Assessment of POCD After TURBT Under Spinal Anesthesia Recruiting NCT03029676 Phase 4 benzodiazepines;opioid
10 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Recruiting NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
11 Ultrasound-Guided ONB for Transurethral Procedures - Interadductor Approach Recruiting NCT02696733 Phase 4 lidocaine 2%;0.9% Natrium Chloratum with a 2nd generation cephalosporin
12 Treatment for Alcohol Dependence With Gabapentin Recruiting NCT02771925 Phase 4 Gabapentin 2g/day divided in two doses for 24 weeks;Placebo 2g/day divided in two doses for 24 weeks
13 Recovery and Analgesia After Surgery for Gynecological Cancer Active, not recruiting NCT02026687 Phase 4
14 The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury Not yet recruiting NCT03029442 Phase 4 Denosumab (Prolia)
15 The Impact of Genotype on Plasma and Cerebral Spinal Fluid Pharmacokinetics of Celecoxib in Children Not yet recruiting NCT01344200 Phase 4 Celecoxib
16 Anderson Circulating Tumor Cell Burden (CTCB) Study Terminated NCT00819832 Phase 4
17 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
18 Effectiveness and Safety of Spondylitis Related to Inflammatory Bowel Disease Withdrawn NCT00972218 Phase 4
19 Evaluation of Vertebral Compression Fracture Fixation With RF Kyphoplasty in Patients With Multiple Myeloma Withdrawn NCT01410929 Phase 4
20 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
21 Trial of IIb Preserving Neck Dissection Unknown status NCT00847717 Phase 3
22 Intrathecal Ketamine, Dexmedetomidine and Both With Bupivacaine for Postoperative Abdominal Cancer Surgery Pain Unknown status NCT02455609 Phase 2, Phase 3 Dexmedetomidine;ketamine;Bupivacaine
23 Brief Intraoperative Electrical Stimulation for Prevention of Shoulder Dysfunction After Oncologic Neck Dissection Unknown status NCT02268344 Phase 3
24 Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas Unknown status NCT00278278 Phase 3 cisplatin;etoposide;ifosfamide;lomustine;methotrexate;prednisone;vincristine sulfate
25 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
26 Study to Improve Outcomes for Survivors of Traumatic Brain Injury in Latin America Unknown status NCT01068522 Phase 3
27 Spinal Cord Compression. ICORG 05-03, V6 Completed NCT00968643 Phase 3
28 Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy Completed NCT00003115 Phase 3 hydromorphone hydrochloride
29 Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer Completed NCT00806611 Phase 3
30 Use of Spinal Sealant System During Spinal Surgery Completed NCT00458354 Phase 3
31 Resistance Exercise Training for the Shoulder and Neck Following Surgery for Head and Neck Cancer Completed NCT00248235 Phase 2, Phase 3
32 Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer Completed NCT00112996 Phase 3 alpha-lipoic acid
33 Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Patients With Metastatic Breast Cancer: Duration of Effect Completed NCT01344967 Phase 2, Phase 3 Zoledronic acid
34 Acupuncture for Post-Thoracotomy Pain Completed NCT00142532 Phase 3
35 Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma Completed NCT01236560 Phase 2, Phase 3 Temozolomide;Vorinostat
36 Postmenopausal Evaluation and Risk-reduction With Lasofoxifene (PEARL) Completed NCT00141323 Phase 3 lasofoxifene;lasofoxifene
37 A Phase III Study of Radium-223 Dichloride in Patients With Symptomatic Hormone Refractory Prostate Cancer With Skeletal Metastases Completed NCT00699751 Phase 3 Radium-223 dichloride (Xofigo, BAY88-8223);Placebo;Best standard of care (BSoC)
38 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed NCT00542542 Phase 3 Propofol;Fentanyl;Ropivacaine;Midazolam
39 Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma. Completed NCT00330759 Phase 3 Zoledronic Acid
40 Optimization of Radiotherapy in Treatment of Painful Bone Metastasis Completed NCT00610272 Phase 3
41 rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study Completed NCT00707265 Phase 3
42 Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children Completed NCT00405522 Phase 3 Propofol + Remifentanil;Propofol + Remifentanil
43 Dynamic Magnetic Resonance (MR) Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research Completed NCT00172224 Phase 3
44 Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma Completed NCT02030717 Phase 2, Phase 3 klonidin;epidural anesthesia
45 Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases Recruiting NCT02512965 Phase 2, Phase 3
46 HDR vs LDR Brachytherapy as Monotherapy in the Treatment of Localized Prostate Cancer. Recruiting NCT02258087 Phase 2, Phase 3
47 Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks Recruiting NCT02051218 Phase 3 Denosumab (reduced dosing);Denosumab (standard dosing)
48 EUS-guided CGN for Inoperable Cancer Recruiting NCT02356640 Phase 2, Phase 3 Levobupivacaine
49 Conventional With Stereotactic Radiotherapy for Pain Reduction and Quality of Life in Spinal Metastases Recruiting NCT02407795 Phase 3
50 Trial of Adjuvant XELOX Chemotherapy and Concurrent Capecitabine and Radiotherapy for Resected Gastric Carcinoma Recruiting NCT01711242 Phase 3 Capecitabine;Oxaliplatin

Search NIH Clinical Center for Spinal Cancer

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: spinal cord neoplasms

Genetic Tests for Spinal Cancer

Genetic tests related to Spinal Cancer:

id Genetic test Affiliating Genes
1 Spinal Cord Tumor 29

Anatomical Context for Spinal Cancer

MalaCards organs/tissues related to Spinal Cancer:

39
Spinal Cord, Brain, Bone, Prostate, Lung, T Cells, Testes

Publications for Spinal Cancer

Articles related to Spinal Cancer:

id Title Authors Year
1
Surgical vertebral body cementoplasty as spinal cancer metastasis management. ( 25548834 )
2014
2
A study investigating the validity of modified Tokuhashi score to decide surgical intervention in patients with metastatic spinal cancer. ( 22899107 )
2013
3
An in vivo mouse model of intraosseous spinal cancer causing evolving paraplegia. ( 23955595 )
2013
4
Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study. ( 17210300 )
2007
5
Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. ( 8893440 )
1996

Variations for Spinal Cancer

Expression for Spinal Cancer

Search GEO for disease gene expression data for Spinal Cancer.

Pathways for Spinal Cancer

Pathways related to Spinal Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.78 SMARCE1 TP53
2 10.32 HOXB13 SMARCE1

GO Terms for Spinal Cancer

Cellular components related to Spinal Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.32 NF2

Biological processes related to Spinal Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 8.32 HOXB13

Sources for Spinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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