Spinal Cord Disease malady

MedlinePlus: Your spinal cord is the part of your nervous system that relays messages to and from your brain. it is housed inside your vertebrae, which are the bone disks that make up your spine. normally, your vertebrae protect your spinal cord. if they don't, you can sustain a spinal cord injury. besides injuries, the spinal cord can develop tumors infections such as meningitis and poliomyelitis inflammatory diseases autoimmune diseases degenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy symptoms vary but might include pain, numbness, loss of sensation and muscle weakness. these symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. treatments vary but often include medicines and surgery.²³

MalaCards: Spinal Cord Disease, also known as spinal cord diseases, is related to spinal muscular atrophy (smn2) and lower motor neuron disease. An important gene associated with Spinal Cord Disease is GDNF (glial cell derived neurotrophic factor). The compounds aminoglycosides and aclarubicin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotype nervous system.

Wikipedia: The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from...⁴⁴ more...

Aliases & Descriptions:

spinal cord disease 6 8 spinal cord diseases 17 32 23 43

Diseases related to spinal cord disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 59)

id	Related Disease	Score	Top Affiliating Genes
1	spinal muscular atrophy (smn2)	13.5	SMN1, SMN2
2	lower motor neuron disease	13.4	SMN2, SMN1
3	juvenile spinal muscular atrophy	13.4	SMN2, SMN1, NAIP
4	spinal muscular atrophy type 2	13.4	SMN2, SMN1, NAIP
5	proximal spinal muscular atrophy	13.4	NAIP, SMN1, SMN2
6	spinal muscular atrophy 1	13.4	NAIP, SMN1, SMN2
7	neuromuscular disease	13.2	GDNF, SMN2, SMN1, NAIP
8	radiculopathy	13.2	COL6A1, HSF4, IFIT1
9	spinal stenosis	13.2	COL6A1, HSF4, IFIT1
10	human t-cell leukemia virus type 2	13.1	HNRNPA1, CNTN2
11	spinal muscular atrophy	13.1	NAIP, IGHMBP2, DDX20, SMN1, SMN2
12	diffuse idiopathic skeletal hyperostosis	13.0	COL6A1, TMTC1
13	motor neuron disease	12.8	GDNF, SMN2, SMN1, DDX20, NAIP, BTD
14	amyotrophic lateral sclerosis	12.7	GDNF, SMN2, SMN1, IGHMBP2, AQP4, NAIP
15	lateral sclerosis	12.7	GDNF, SMN2, SMN1, IGHMBP2, AQP4, NAIP
16	transverse myelitis	12.7	MBP, AQP4
17	human t-cell leukemia virus type 1	12.5	GDNF, HNRNPA1, ATM, CNTN2
18	paralysis	12.4	GDNF, SMN1, IGHMBP2, MBP, NAIP
19	myelitis	12.4	ATM, AQP4, MBP
20	muscular atrophy	12.4	GDNF, SMN2, SMN1, DDX20, HNRNPA1L2, HNRNPA1
21	gliosis	12.3	AQP4, MBP, GDNF
22	progressive multifocal leukoencephalopathy	12.3	IGHMBP2, MBP, CD4
23	central pontine myelinolysis	12.3	BTD, AQP4, MBP
24	neuromyelitis optica	12.2	AQP4, MBP, HLA-A
25	adult t-cell leukemia	12.2	HBZ, HLA-A, SERPINH1, CNTN2
26	htlv-1 associated myelopathy	12.2	CNTN2, MBP, HLA-A
27	t-cell leukemia	12.1	CNTN2, ATM, CD4, HNRNPA1
28	muscular dystrophy	12.1	GDNF, COL6A1, SMN1, HLA-A, HNRNPA1, AQP4
29	optic neuritis	12.1	HLA-A, MBP, AQP4
30	relapsing-remitting multiple sclerosis	12.1	MBP, HLA-A, GDNF
31	neurologic diseases	12.1	CNTN2, AQP4, MBP, HNRNPA1
32	aicardi-goutieres syndrome	12.0	MBP, AQP4, CD4, BTD
33	polyneuropathy	12.0	GDNF, MBP, CD4, CNTN2
34	lymphoproliferative syndrome	12.0	HLA-A, CD4, ATM, CNTN2
35	encephalitis	11.9	GDNF, IFIT1, MBP, AQP4, CD4
36	meningitis	11.9	GDNF, HSF4, MBP, AQP4, CD4
37	neurodegenerative disease	11.8	GDNF, SMN1, MBP, ATM, NAIP, CNTN2
38	htlv-1 associated myelopathy/tropical spastic paraparesis	11.7	HLA-A, MBP
39	tetanus	11.6	GDNF, SMN1, HLA-A, MBP, CD4
40	myopathy	11.6	BTD, CD4, AQP4, IGHMBP2, HLA-A, SMN1
41	laryngitis	11.4	BTD, ATM, CD4, HLA-A, GDNF
42	acquired immunodeficiency syndrome	11.4	GDNF, HLA-A, MBP, CD4
43	neurodegeneration	11.2	GDNF, SMN1, MBP, CD4, ATM, NAIP
44	astrocytoma	11.1	GDNF, COL6A1, MBP, AQP4, CD4, ATM
45	herpes simplex	11.0	GDNF, MBP, AQP4, CD4, ATM, CNTN2
46	hypersensitivity reaction type ii disease	10.9	HLA-A, MBP, AQP4, CD4, SERPINH1, NCL
47	spastic paraparesis	10.6	HBZ, LTV1, HLA-A, MBP, CD4, SERPINH1
48	spasticity	10.6	HBZ, LTV1, HLA-A, MBP, CD4, SERPINH1
49	tropical spastic paraparesis	10.3	HBZ, CNTN2, SERPINH1, CD4, MBP, HNRNPA1
50	multiple sclerosis	10.3	GDNF, HLA-A, MBP, AQP4, CD4, ATM

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spinal cord disease:

²²

MGI Mouse Phenotypes related to spinal cord disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	7.0	CNTN2, SMN1, GNB1L, IGHMBP2, MBP, AQP4

Articles related to spinal cord disease:

id	Title	Authors	Year	Affiliating Genes
1	Profound biotinidase deficiency in a child with predominantly spinal cord disease. (18645204)	Chedrawi A.K.... Wolf B.	2008	BTD

Genes related to spinal cord disease according to GeneCards:

(show all 25)

id	Symbol	Description	Score	GeneCards Section Context
1	GDNF	glial cell derived neurotrophic factor	11.1
2	NAIP	NLR family, apoptosis inhibitory protein	11.0
3	DDX20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	11.0
4	IGHMBP2	immunoglobulin mu binding protein 2	11.0
5	SMN2	survival of motor neuron 2, centromeric	11.0
6	SMN1	survival of motor neuron 1, telomeric	11.0
7	IFIT1	interferon-induced protein with tetratricopeptide repeats 1	11.0
8	HBZ	hemoglobin, zeta	11.0
9	HSF4	heat shock transcription factor 4	11.0
10	LTV1	LTV1 homolog (S. cerevisiae)	11.0
11	COL6A1	collagen, type VI, alpha 1	11.0
12	HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2	11.0	Disorders
13	GNB1L	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	11.0	Disorders
14	ISM1	isthmin 1 homolog (zebrafish)	11.0
15	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.0
16	AQP4	aquaporin 4	11.0
17	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	11.0
18	CNTN2	contactin 2 (axonal)	11.0
19	BTD	biotinidase	11.0	Publications
20	NCL	nucleolin	11.0
21	ATM	ataxia telangiectasia mutated	11.0
22	CD4	CD4 molecule	11.0
23	MBP	myelin basic protein	11.0
24	HLA-A	major histocompatibility complex, class I, A	11.0
25	TMTC1	transmembrane and tetratricopeptide repeat containing 1	11.0

Compounds related to spinal cord disease according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	aminoglycosides32	10.2	SMN1, GDNF
2	aclarubicin32	10.1	SMN2, SMN1
3	galactosylceramide32	9.2	CD4, MBP
4	phosphoserine32 18	10.1	CNTN2, CD4, MBP
5	okadaic acid32 42	9.9	GDNF, MBP, ATM, NCL
6	ganglioside32	8.9	CD4, MBP, GDNF
7	cysteine32	7.9	GDNF, COL6A1, MBP, AQP4, CD4, NAIP
8	arginine32	7.7	HLA-A, MBP, BTD, CNTN2, NCL, SMN1
9	oligonucleotide32	7.3	NCL, GDNF, HBZ, SMN2, SMN1, HLA-A
10	tyrosine32	6.2	GDNF, SMN1, HLA-A, HNRNPA1, MBP, CD4

Cellular components related to spinal cord disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	spliceosomal complex	GO:005681	9.6	HNRNPA1, HNRNPA1L2, DDX20, SMN2

Molecular functions related to spinal cord disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	RNA binding	GO:003723	9.0	NCL, IGHMBP2, IFIT1, HNRNPA1, HNRNPA1L2, SMN2