MCID: SPN041
MIFTS: 37

Spinal Cord Disease malady

Neuronal diseases category

Summaries for Spinal Cord Disease

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. it is protected by your vertebrae, which are the bone disks that make up your spine. if you have an accident that damages the vertebrae or other parts of the spine, this can also injure the spinal cord. other spinal cord problems include tumors infections such as meningitis and polio inflammatory diseases autoimmune diseases degenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy symptoms vary but might include pain, numbness, loss of sensation and muscle weakness. these symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. treatments often include medicines and surgery.

MalaCards: Spinal Cord Disease, also known as spinal cord diseases, is related to cervicitis and detrusor sphincter dyssynergia. An important gene associated with Spinal Cord Disease is COL6A1 (collagen, type VI, alpha 1), and among its related pathways is NCAM signaling for neurite out-growth. The compounds ganglioside and monensin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

Wikipedia:66 The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from... more...

Aliases & Classifications for Spinal Cord Disease

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spinal cord disease 9 11
spinal cord diseases 46 35 63


External Ids:

Disease Ontology9 DOID:319
MeSH36 D013118
ICD9CM28 336.9
ICD1026 G95.8

Related Diseases for Spinal Cord Disease

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Spinal Cord Disease:



Diseases related to spinal cord disease

Symptoms for Spinal Cord Disease

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Drugs & Therapeutics for Spinal Cord Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Spinal Cord Disease

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Genetic Tests for Spinal Cord Disease

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Anatomical Context for Spinal Cord Disease

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34MalaCards
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MalaCards organs/tissues related to Spinal Cord Disease:

34
Spinal cord, Brain, Bone, Medulla oblongata, Testes

Animal Models for Spinal Cord Disease or affiliated genes

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Publications for Spinal Cord Disease

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Sources:
53PubMed
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Articles related to Spinal Cord Disease:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Depression and pain among inpatients with spinal cord injury and spinal cord disease: differences in symptoms and neurological function. (23072715)
2013
2
STIR muscle hyperintensity in the cervical muscles associated with inflammatory spinal cord disease of unknown origin. (23458643)
2013
3
Low serum vitamin D levels and recurrent inflammatory spinal cord disease. (22083799)
2012
4
Stress, internal resources and functioning in a person with spinal cord disease. (22430577)
2012
5
Anorectal function and the effect of biofeedback therapy in ambulatory spinal cord disease patients having constipation. (20602567)
2010
6
Clinical and magnetic resonance imaging findings in 92 cats with clinical signs of spinal cord disease. (18602328)
2009
7
Characterization of spatiotemporal gait characteristics in clinically normal dogs and dogs with spinal cord disease. (19951114)
2009
8
Profound biotinidase deficiency in a child with predominantly spinal cord disease. (18645204)
2008
9
Signs of spinal cord disease in two heifers caused by Listeria monocytogenes. (14758832)
2004
10
Spinal cord disease in West Nile virus infection. (12575663)
2003
11
Spinal cord disease in West Nile virus infection. (12571269)
2003
12
From the electrodiagnosis lab...H-reflexes in hand muscles after cervical spinal cord disease. (14598812)
2003
13
Correlation between severity of clinical signs and motor evoked potentials after transcranial magnetic stimulation in large-breed dogs with cervical spinal cord disease. (12420825)
2002
14
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. (12121731)
2002
15
Electrophysiological evaluation of root and spinal cord disease. (12524565)
2002
16
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
17
The effects of capsaicin on the neurogenic hyperreflexic detrusor. A double blind placebo controlled study in patients with spinal cord disease. Preliminary results. (9494998)
1998
18
Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. (8649545)
1996
19
Vertebrospinal angiography in the evaluation of vertebral and spinal cord disease. (8873094)
1996
20
Spinal cord disease due to vacuolar myelopathy in AIDS. (8039791)
1994
21
Spontaneous ejaculation secondary to spinal cord disease. (8164008)
1994
22
Somatosensory potentials in dogs with naturally acquired thoracolumbar spinal cord disease. (8291776)
1993
23
The diagnostic impact of magnetic resonance imaging on the evaluation of suspected spinal cord disease. (1441553)
1992
24
Congenital, hereditary and developmental spinal cord disease. (1325226)
1992
25
Management of bowel dysfunction in children with spinal cord disease or injury by means of the enema continence catheter. (1735813)
1992
26
Repair and regeneration: experimental aspects of spinal cord disease. (1515695)
1992
27
Disturbed sexual function in patients with spinal cord disease. (1921957)
1991
28
Rehabilitation of patients with spinal cord disease. (1921954)
1991
29
Medical management of spinal cord disease. (3113696)
1987
30
Spinal-evoked potentials in dogs with acute compressive thoracolumbar spinal cord disease. (3674565)
1987
31
The value of paraxial slices in MR-imaging of spinal cord disease. (3762914)
1986
32
A method of calculating spinal cord transit time from potentials evoked by tibial nerve stimulation in normal subjects and in patients with spinal cord disease. (6200309)
1984
33
The use of the Dienes test in the epidemiology of proteus urinary tract infections in patients with spinal cord disease. (6202754)
1984
34
Spinal cord disease due to Schistosoma mansoni successfully treated with oxamniquine. (6424851)
1984
35
The pattern visual evoked potential in the clinical assessment of undiagnosed spinal cord disease. (7054971)
1982
36
Acute spinal cord disease in childhood. (7286458)
1981
37
A pathological survey of 41 cases of acute intrinsic spinal cord disease. (479912)
1979
38
Inverted knee jerk: a neglected localising sign in spinal cord disease. (501364)
1979
39
Medical complications and economic aspects of management of permanent spinal cord disease. (638902)
1978
40
Spinal cord disease in the horse. (618720)
1978
41
Spinal cord disease in hereditary spherocytosis: report of two cases with a hypothesized common mechanism for neurologic and red cell abnormalities. (949548)
1976
42
Microneurosurgery: application of the binocular surgical microscope in brain tumors, intracranial aneurysms, spinal cord disease, and nerve reconstruction. (4945160)
1968
43
The influence of chlorhexidine irrigations on bacterial counts of the bladder urine in spinal cord disease. (5966986)
1966
44
Some circulatory responses to Valsalva's manoeuvre in patients with polyneuritis and spinal cord disease. (14005316)
1962
45
Home-handling of a patient with severe spinal cord disease. (13645384)
1959
46
Flexion spasms and contractures in spinal-cord disease. (13526262)
1958
47
Diagnosis of spinal cord disease. (14881833)
1951
48
Vesical evidence of posterolateral spinal cord disease. (14861943)
1951
49
Progressive spinal cord disease; syndromes associated with herniation of cervical intervertebral disks. (14823886)
1951
50
A Clinical Lecture ON TWO CASES OF SPINAL CORD DISEASE CONSEQUENT ON SYPHILIS. (20760096)
1902

Variations for Spinal Cord Disease

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Expression for genes affiliated with Spinal Cord Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Disease

Search GEO for disease gene expression data for Spinal Cord Disease.

Pathways for genes affiliated with Spinal Cord Disease

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51PathCards, 56Reactome
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Pathways related to Spinal Cord Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8COL6A1, GDNF

Compounds for genes affiliated with Spinal Cord Disease

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank
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Compounds related to Spinal Cord Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ganglioside469.5CD4, GDNF
2monensin469.5SERPINH1, CD4
3bafilomycin a146 62 1211.4CD4, SERPINH1
4oligonucleotide468.6CD4, SERPINH1, HBZ, GDNF
5cysteine468.6CD4, BTD, COL6A1, GDNF
6tyrosine468.5GDNF, SERPINH1, HNRNPA1, BTD, CD4

GO Terms for genes affiliated with Spinal Cord Disease

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17Gene Ontology
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Cellular components related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.2CD4, COL6A1, SERPINH1

Products for genes affiliated with Spinal Cord Disease

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  • Antibodies
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  • Antibodies

Sources for Spinal Cord Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet