MCID: SPN041
MIFTS: 43

Spinal Cord Disease malady

Neuronal diseases category

Summaries for Spinal Cord Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. it is protected by your vertebrae, which are the bone disks that make up your spine. if you have an accident that damages the vertebrae or other parts of the spine, this can also injure the spinal cord. other spinal cord problems include tumors infections such as meningitis and polio inflammatory diseases autoimmune diseases degenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy symptoms vary but might include pain, numbness, loss of sensation and muscle weakness. these symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. treatments often include medicines and surgery.

MalaCards: Spinal Cord Disease, also known as spinal cord diseases, is related to neuropathy and multiple sclerosis. An important gene associated with Spinal Cord Disease is GDNF (glial cell derived neurotrophic factor), and among its related pathways are snRNP Assembly and NCAM signaling for neurite out-growth. The compounds aminoglycosides and aclarubicin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

Wikipedia:63 The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from... more...

Aliases & Classifications for Spinal Cord Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spinal cord disease 8 10
spinal cord diseases 44 33 60


External Ids:

Disease Ontology8 DOID:319
ICD9CM27 336.9
MeSH34 D013118
ICD1025 G95.8

Related Diseases for Spinal Cord Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spinal Cord Disease:



Diseases related to spinal cord disease

Clinical Features for Spinal Cord Disease

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Drugs & Therapeutics for Spinal Cord Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spinal Cord Disease

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Anatomical Context for Spinal Cord Disease

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32MalaCards
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MalaCards organs/tissues related to Spinal Cord Disease:

32
Spinal cord, Brain, Bone, Medulla oblongata, Heart, Cortex, Kidney, Testes, T cells

Animal Models for Spinal Cord Disease or affiliated genes

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Publications for Spinal Cord Disease

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50PubMed
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Articles related to Spinal Cord Disease:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Cardiovascular disease and spinal cord injury: results from a national population health survey. (23884034)
2013
2
STIR muscle hyperintensity in the cervical muscles associated with inflammatory spinal cord disease of unknown origin. (23458643)
2013
3
Effect of ventral slot procedure on spinal cord compression in dogs with single static intervertebral disc disease: preliminary findings while evaluating a semiquantitative computed tomographic myelographic score of spinal cord compression. (23240963)
2013
4
Simultaneous Moyamoya disease and cervical spinal cord low-grade astrocytoma in a child with neurofibromatosis type 1. (23661665)
2013
5
Anterior spinal cord syndrome in a patient with BehAset's disease. (22892002)
2012
6
The extent of ultrastructural spinal cord pathology reflects disease severity in experimental autoimmune encephalomyelitis. (22806903)
2012
7
Stress, internal resources and functioning in a person with spinal cord disease. (22430577)
2012
8
Cardiovascular disease risk and the need for prevention after paraplegia determined by conventional multifactorial risk models: the Stockholm spinal cord injury study. (21305240)
2011
9
Neurogenic bowel dysfunction in patients with spinal cord injury, myelomeningocele, multiple sclerosis and Parkinson's disease. (22171138)
2011
10
Spinal cord stimulation in the treatment of postherpetic neuralgia in patients with chronic kidney disease: a case series and review of the literature. (21935494)
2011
11
Long-term stability after multilevel cervical laminectomy for spinal cord tumor resection in von Hippel-Lindau disease. (21275550)
2011
12
Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits. (19142195)
2009
13
Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease. (19576518)
2009
14
Monotherapy with thalidomide for treatment of spinal cord hemangioblastomas in a patient with von Hippel-Lindau disease. (19415739)
2009
15
Spinal cord stimulation for the treatment of angina and peripheral vascular disease. (19126366)
2009
16
Surgical management of pressure ulcers during inpatient neurologic rehabilitation: outcomes for patients with spinal cord disease. (19569459)
2009
17
Rehabilitation outcomes after infection-related spinal cord disease: a retrospective analysis. (18356619)
2008
18
The utilization of transcutaneous oxygen pressures to guide decision-making for spinal cord stimulation implantation for inoperable peripheral vascular disease: a report of two cases. (19057636)
2008
19
Plasmablastic lymphoma: a case of rectal disease with spinal cord compression. (17169819)
2006
20
Rosai-Dorfman disease involving the cranial base, paranasal sinuses and spinal cord. (16033137)
2005
21
From the electrodiagnosis lab...H-reflexes in hand muscles after cervical spinal cord disease. (14598812)
2003
22
Spinal cord stimulation for angina pectoris and peripheral vascular disease. (14719720)
2003
23
FKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients. (12564766)
2002
24
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. (12121731)
2002
25
Evidence for pathological involvement of the spinal cord in motor neuron disease-inclusion dementia. (11907801)
2002
26
The use of magnetic motor evoked potentials in horses with cervical spinal cord disease. (11902758)
2002
27
Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. (8649545)
1996
28
Vertebrospinal angiography in the evaluation of vertebral and spinal cord disease. (8873094)
1996
29
The diagnostic impact of magnetic resonance imaging on the evaluation of suspected spinal cord disease. (1441553)
1992
30
Management of bowel dysfunction in children with spinal cord disease or injury by means of the enema continence catheter. (1735813)
1992
31
Granulomatous angiitis of the spinal cord associated with Hodgkin's disease. (1873784)
1991
32
Disturbed sexual function in patients with spinal cord disease. (1921957)
1991
33
Spinal cord disease in children with HIV-1 infection: a combined molecular biological and neuropathological study. (2234312)
1990
34
Cerebrospinal fluid immunoreactive substance P and somatostatin in neurological patients with peripheral and spinal cord disease. (2468107)
1988
35
Medical management of spinal cord disease. (3113696)
1987
36
Magnetic resonance imaging of spinal cord disease of childhood. (3737301)
1986
37
Spinal cord infarction in disease and surgery of the aorta. (3910209)
1985
38
Spinal cord disease due to Schistosoma mansoni successfully treated with oxamniquine. (6432214)
1984
39
The pattern visual evoked potential in the clinical assessment of undiagnosed spinal cord disease. (7054971)
1982
40
Morphological and morphometric studies on the spinal cord lesion in Werdnig-Hoffmann disease. (7201252)
1982
41
Acute spinal cord disease in childhood. (7286458)
1981
42
Spinal autonomic neurons in Werdnig-Hoffmann disease, mannosidosis, and Hurler's syndrome: distribution of autonomic neurons in the sacral spinal cord. (6783738)
1980
43
Infarction of spinal cord. Two cases of selective gray matter involvement secondary to asymptomatic aortic disease. (5101615)
1971
44
Microneurosurgery: application of the binocular surgical microscope in brain tumors, intracranial aneurysms, spinal cord disease, and nerve reconstruction. (4945160)
1968
45
A CASE of gallbladder disease and spinal cord tumor. (13857106)
1959
46
Home-handling of a patient with severe spinal cord disease. (13645384)
1959
47
Flexion spasms and contractures in spinal-cord disease. (13526262)
1958
48
Double simultaneous stimulation phenomena in spinal cord disease. (13002601)
1952
49
Vesical evidence of posterolateral spinal cord disease. (14861943)
1951
50
Lindauvon Hippel disease with hemangioblastoma of the spinal cord and syringomyelia. (20243511)
1947

Genetic Variations for Spinal Cord Disease

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Expression for genes affiliated with Spinal Cord Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Disease

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Pathways for genes affiliated with Spinal Cord Disease

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53Reactome
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Pathways related to Spinal Cord Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1SMN1, DDX20
2
Hide members
9.9GDNF, CNTN2, COL6A1

Compounds for genes affiliated with Spinal Cord Disease

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Spinal Cord Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aminoglycosides4410.2SMN1, GDNF
2aclarubicin4410.1SMN1, SMN2
3phenylbutyrate4410.1SMN1, SMN2
4valproic acid44 49 11 2412.8BTD, SMN1, SMN2
5cysteine449.3AQP4, COL6A1, CNTN2, BTD, GDNF, NAIP
6oligonucleotide448.6AQP4, NCL, CNTN2, HBZ, GDNF, SERPINH1
7tyrosine448.5SMN1, GDNF, BTD, CNTN2, NCL, HNRNPA1

GO Terms for genes affiliated with Spinal Cord Disease

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16Gene Ontology
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Cellular components related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Gemini of coiled bodiesGO:09750410.0SMN2, DDX20
2spliceosomal complexGO:0056819.6SMN2, DDX20, HNRNPA1, HNRNPA1L2
3ribonucleoprotein complexGO:0305299.4HNRNPA1, NCL, IGHMBP2
4cytoplasmGO:0057378.1HNRNPA1, IFIT1, GNB1L, DDX20, IGHMBP2, LTV1

Biological processes related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spliceosomal snRNP assemblyGO:00038710.1SMN2, DDX20
2ncRNA metabolic processGO:0346609.8SMN2, DDX20

Molecular functions related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037238.9SMN2, IGHMBP2, NCL, IFIT1, HNRNPA1, HNRNPA1L2

Products for genes affiliated with Spinal Cord Disease

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Sources for Spinal Cord Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet