MCID: SPN041
MIFTS: 39

Spinal Cord Disease malady

Neuronal category

Summaries for Spinal Cord Disease

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. it is protected by your vertebrae, which are the bone disks that make up your spine. if you have an accident that damages the vertebrae or other parts of the spine, this can also injure the spinal cord. other spinal cord problems include tumors infections such as meningitis and polio inflammatory diseases autoimmune diseases degenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy symptoms vary but might include pain, numbness, loss of sensation and muscle weakness. these symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. treatments often include medicines and surgery.

MalaCards: Spinal Cord Disease, also known as spinal cord diseases, is related to spinal cord injury and detrusor sphincter dyssynergia. An important gene associated with Spinal Cord Disease is GDNF (glial cell derived neurotrophic factor), and among its related pathways are snRNP Assembly and NCAM signaling for neurite out-growth. The compounds aminoglycosides and aclarubicin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord.

Wikipedia:64 The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from... more...

Aliases & Classifications for Spinal Cord Disease

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

spinal cord disease 8 10
spinal cord diseases 45 34 61


External Ids:

Disease Ontology8 DOID:319
ICD9CM27 336.9
MeSH35 D013118
ICD1025 G95.8

Related Diseases for Spinal Cord Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spinal Cord Disease:



Diseases related to spinal cord disease

Clinical Features for Spinal Cord Disease

Drugs & Therapeutics for Spinal Cord Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Spinal Cord Disease

Search NIH Clinical Center for Spinal Cord Disease

Search CenterWatch for Spinal Cord Disease

Genetic Tests for Spinal Cord Disease

Anatomical Context for Spinal Cord Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Spinal Cord Disease:

33
Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Kidney, T cells, Medulla oblongata

Animal Models for Spinal Cord Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Spinal Cord Disease

Sources:
51PubMed
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Articles related to Spinal Cord Disease:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Baseline prevalence of heart diseases, hypertension, diabetes, and obesity in persons with acute traumatic spinal cord injury: potential threats in the recovery trajectory. (23960701)
2013
2
Longitudinal association between lifestyle and coronary heart disease risk factors among individuals with spinal cord injury. (23208541)
2013
3
STIR muscle hyperintensity in the cervical muscles associated with inflammatory spinal cord disease of unknown origin. (23458643)
2013
4
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. (23924924)
2013
5
Noninvasive respiratory management and diaphragm and electrophrenic pacing in neuromuscular disease and spinal cord injury. (23349084)
2013
6
Unusual imaging findings in brain and spinal cord in two siblings with maple syrup urine disease. (23279201)
2013
7
The extent of ultrastructural spinal cord pathology reflects disease severity in experimental autoimmune encephalomyelitis. (22806903)
2012
8
Spinal cord disease in patients with cancer. (22810129)
2012
9
Spinal cord stimulation in the treatment of postherpetic neuralgia in patients with chronic kidney disease: a case series and review of the literature. (21935494)
2011
10
Increased cardiovascular disease risk in Swedish persons with paraplegia: The Stockholm spinal cord injury study. (20544162)
2010
11
Clinical and magnetic resonance imaging findings in 92 cats with clinical signs of spinal cord disease. (18602328)
2009
12
Monotherapy with thalidomide for treatment of spinal cord hemangioblastomas in a patient with von Hippel-Lindau disease. (19415739)
2009
13
Spinal cord stimulation for the treatment of angina and peripheral vascular disease. (19126366)
2009
14
Spinal cord hemangioblastomas in von Hippel-Lindau disease. (19030009)
2009
15
Extranodal Rosai-Dorfman disease with multifocal bone and epidural involvement causing recurrent spinal cord compression. (16211443)
2005
16
Neuropathologic characteristics of spinal cord lesions in sporadic Creutzfeldt-Jakob disease. (16175355)
2005
17
Rosai-Dorfman disease involving the cranial base, paranasal sinuses and spinal cord. (16033137)
2005
18
Thromboangiitis obliterans (Buerger disease) in a female mild smoker treated with spinal cord stimulation. (15201654)
2004
19
Spinal cord stimulation in the treatment of peripheral vascular disease: results of a single-center study of 258 patients. (15026864)
2004
20
Spinal cord infarction secondary to intervertebral foraminal disease. (15249926)
2004
21
Spinal cord disease in West Nile virus infection. (12571269)
2003
22
Correlation between severity of clinical signs and motor evoked potentials after transcranial magnetic stimulation in large-breed dogs with cervical spinal cord disease. (12420825)
2002
23
Electrophysiological evaluation of root and spinal cord disease. (12524565)
2002
24
Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease. (12586554)
2002
25
Compression of spinal cord and cauda equina in Charcot-Marie-Tooth disease type 1A. (10078755)
1999
26
Spinal cord disease due to melioidosis. (10450444)
1999
27
Improvement of microcirculatory blood flow under epidural spinal cord stimulation in patients with nonreconstructible peripheral arterial occlusive disease. (9148705)
1997
28
Coronary heart disease risk indicators, aerobic power, and physical activity in men with spinal cord injuries. (9228871)
1997
29
Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. (8649545)
1996
30
Vertebrospinal angiography in the evaluation of vertebral and spinal cord disease. (8873094)
1996
31
Spinal cord swelling as a myelographic indicator of prognosis: a retrospective study in dogs with intervertebral disc disease and loss of deep pain perception. (8719081)
1996
32
Serotonergic neurotransmission in the spinal cord and motor cortex of patients with motor neuron disease and controls: quantitative autoradiography for 5-HT1a and 5-HT2 receptors. (8899664)
1996
33
Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease. (7666056)
1995
34
Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease. (7585015)
1995
35
Spontaneous ejaculation secondary to spinal cord disease. (8164008)
1994
36
Human T-lymphotropic virus type I DNA in spinal cord of tropical spastic paraparesis with concomitant human T-lymphotropic virus type I-negative Hodgkin's disease. (7927317)
1994
37
Somatosensory potentials in dogs with naturally acquired thoracolumbar spinal cord disease. (8291776)
1993
38
Characterisation of the distribution of choline acetyltransferase messenger RNA in human spinal cord and its depletion in motor neurone disease. (1469422)
1992
39
Repair and regeneration: experimental aspects of spinal cord disease. (1515695)
1992
40
Pathology of roots, spinal cord and brainstem in syringomyelia-like syndrome of Tangier disease. (1802966)
1991
41
Rehabilitation of patients with spinal cord disease. (1921954)
1991
42
Medical complications of spinal cord disease. (1921958)
1991
43
Spinal cord disease due to Schistosoma mansoni successfully treated with oxamniquine. (6424851)
1984
44
Acute spinal cord compression in Scheuermann's disease. (7096412)
1982
45
Dermatomes, sensory levels and spinal cord disease. (6121464)
1981
46
Infarction of spinal cord. Two cases of selective gray matter involvement secondary to asymptomatic aortic disease. (5101615)
1971
47
Home-handling of a patient with severe spinal cord disease. (13645384)
1959
48
Diagnosis of spinal cord disease. (14881833)
1951
49
Lindauvon Hippel disease with hemangioblastoma of the spinal cord and syringomyelia. (20243511)
1947
50
A Clinical Lecture ON TWO CASES OF SPINAL CORD DISEASE CONSEQUENT ON SYPHILIS. (20760096)
1902

Genetic Variations for Spinal Cord Disease

Expression for genes affiliated with Spinal Cord Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Disease

Search GEO for disease gene expression data for Spinal Cord Disease.

Pathways for genes affiliated with Spinal Cord Disease

Sources:
54Reactome
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Pathways related to Spinal Cord Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1SMN1, DDX20
2
Hide members
9.9GDNF, CNTN2, COL6A1

Compounds for genes affiliated with Spinal Cord Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Spinal Cord Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aminoglycosides4510.2SMN1, GDNF
2aclarubicin4510.1SMN1, SMN2
3phenylbutyrate4510.1SMN1, SMN2
4valproic acid45 50 11 2412.8BTD, SMN1, SMN2
5cysteine459.3AQP4, COL6A1, CNTN2, BTD, GDNF, NAIP
6oligonucleotide458.6AQP4, NCL, CNTN2, HBZ, GDNF, SERPINH1
7tyrosine458.5SMN1, GDNF, BTD, CNTN2, NCL, HNRNPA1

GO Terms for genes affiliated with Spinal Cord Disease

Sources:
16Gene Ontology
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Cellular components related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Gemini of coiled bodiesGO:09750410.0SMN2, DDX20
2spliceosomal complexGO:0056819.6SMN2, DDX20, HNRNPA1, HNRNPA1L2
3ribonucleoprotein complexGO:0305299.4HNRNPA1, NCL, IGHMBP2
4cytoplasmGO:0057378.1NAIP, AQP4, HNRNPA1L2, HNRNPA1, IFIT1, GNB1L

Biological processes related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spliceosomal snRNP assemblyGO:00038710.1SMN2, DDX20
2ncRNA metabolic processGO:0346609.8SMN2, DDX20

Molecular functions related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037238.9SMN2, IGHMBP2, NCL, IFIT1, HNRNPA1, HNRNPA1L2

Products for genes affiliated with Spinal Cord Disease

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  • Lysates
  • Antibodies

Sources for Spinal Cord Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet