MCID: SPN041
MIFTS: 43

Spinal Cord Disease malady

Neuronal diseases category

Summaries for Spinal Cord Disease

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. it is protected by your vertebrae, which are the bone disks that make up your spine. if you have an accident that damages the vertebrae or other parts of the spine, this can also injure the spinal cord. other spinal cord problems include tumors infections such as meningitis and polio inflammatory diseases autoimmune diseases degenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy symptoms vary but might include pain, numbness, loss of sensation and muscle weakness. these symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. treatments often include medicines and surgery.

MalaCards: Spinal Cord Disease, also known as spinal cord diseases, is related to neuropathy and multiple sclerosis. An important gene associated with Spinal Cord Disease is GDNF (glial cell derived neurotrophic factor), and among its related pathways are snRNP Assembly and NCAM signaling for neurite out-growth. The compounds aminoglycosides and aclarubicin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

Wikipedia:63 The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from... more...

Aliases & Classifications for Spinal Cord Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spinal cord disease 8 10
spinal cord diseases 44 33 60


External Ids:

Disease Ontology8 DOID:319
ICD9CM27 336.9
MeSH34 D013118
ICD1025 G95.8

Related Diseases for Spinal Cord Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spinal Cord Disease:



Diseases related to spinal cord disease

Clinical Features for Spinal Cord Disease

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Drugs & Therapeutics for Spinal Cord Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spinal Cord Disease

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Anatomical Context for Spinal Cord Disease

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32MalaCards
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MalaCards organs/tissues related to Spinal Cord Disease:

32
Spinal cord, Brain, Bone, Medulla oblongata, Heart, Cortex, Kidney, Testes, T cells

Animal Models for Spinal Cord Disease or affiliated genes

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Publications for Spinal Cord Disease

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50PubMed
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Articles related to Spinal Cord Disease:

(show top 50)    (show all 203)
idTitleAuthorsYear
1
Waist circumference is the best index for obesity-related cardiovascular disease risk in individuals with spinal cord injury. (24070685)
2014
2
Spinal cord atrophy correlates with disease duration and severity in amyotrophic lateral sclerosis. (24219347)
2013
3
Coexistence of amyotrophic lateral sclerosis with neuro-BehAset's disease presenting as a longitudinally extensive spinal cord lesion: clinicopathologic features of an autopsied patient. (24118427)
2013
4
Positron emission tomography in spinal cord disease. (24182699)
2013
5
Erdheim-Chester disease presenting with an intramedullary spinal cord lesion. (22638564)
2012
6
Spinal cord stimulation for chronic pain originating from Lyme disease. (23159969)
2012
7
MRI of cervical spinal cord infarction in a patient with sickle cell disease. (22920369)
2012
8
Expression of tau-related protein in spinal cord of patients with Alzheimer's disease]. (21575385)
2011
9
Fighting spinal cord complication during surgery for thoracoabdominal aortic disease. (21308433)
2011
10
Anorectal function and the effect of biofeedback therapy in ambulatory spinal cord disease patients having constipation. (20602567)
2010
11
Neuropathological changes in the peripheral nervous system and spinal cord in a transgenic mouse model of Niemann-Pick disease type A. (19642505)
2009
12
First case of extensive spinal cord infection with Aspergillus nidulans in a child with chronic granulomatous disease. (19759498)
2009
13
Characterization of spatiotemporal gait characteristics in clinically normal dogs and dogs with spinal cord disease. (19951114)
2009
14
Profound biotinidase deficiency in a child with predominantly spinal cord disease. (18645204)
2008
15
Detection of spinal cord compression in dogs with cervical intervertebral disc disease by magnetic resonance imaging. (18603629)
2008
16
Spinal cord stimulation for ischemic heart disease and peripheral vascular disease. (17907475)
2007
17
Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease. (16545011)
2006
18
Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review. (16158216)
2006
19
Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement. (17203592)
2006
20
Neurogenic bladder dysfunction in patients with neoplastic spinal cord compression: adaptation of the bladder management strategy to the underlying disease. (16720939)
2006
21
Spinal cord compression as a result of Rosai-Dorfman disease of the upper cervical spine in a child. (15650889)
2005
22
Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease. (15649703)
2005
23
Signs of spinal cord disease in two heifers caused by Listeria monocytogenes. (14758832)
2004
24
Spinal cord disease in West Nile virus infection. (12575663)
2003
25
Spinal cord stimulation in peripheral vascular disease and angina pectoris. (14631672)
2003
26
Metastasis of renal cell carcinoma to haemangioblastoma of the spinal cord in von Hippel-Lindau disease: case report and review of the literature. (14506966)
2003
27
Spinal cord stimulation in the treatment of non-reconstructable stable critical leg ischaemia: results of the European Peripheral Vascular Disease Outcome Study (SCS-EPOS). (14509891)
2003
28
Continuous noninvasive ventilation for patients with neuromuscular disease and spinal cord injury. (16088621)
2002
29
Spinal cord stimulation in peripheral vascular disease: a retrospective analysis of 95 cases. (17147573)
2001
30
Spinal cord involvement in CNS Whipple disease: an ongoing experience in the magnetic resonance imaging era. (11733340)
2001
31
Concentrations of trace minerals in the spinal cord of horses with equine motor neuron disease. (10850833)
2000
32
Implantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans (Buerger's disease). (10231644)
1999
33
Immunocytochemical study of the distribution of the free radical scavenging enzymes Cu/Zn superoxide dismutase (SOD1); MN superoxide dismutase (MN SOD) and catalase in the normal human spinal cord and in motor neuron disease. (9106116)
1997
34
Spinal cord disease due to vacuolar myelopathy in AIDS. (8039791)
1994
35
Magnetic motor evoked potentials for assessing spinal cord integrity in dogs with intervertebral disc disease. (8488675)
1993
36
Spinal cord MRI in adult polyglucosan body disease. (1522280)
1992
37
Extensive replacement of spinal cord and brainstem by hemangioblastoma in a case of von Hippel-Lindau disease. (1764853)
1991
38
Ubiquitinated filamentous inclusions in spinal cord of patients with motor neuron disease. (2166261)
1990
39
Cervical spine: MR imaging with a partial flip angle, gradient-refocused pulse sequence. Part II. Spinal cord disease. (3336723)
1988
40
MR imaging of spinal cord in Devic disease. (3571597)
1987
41
Spinal cord decompression for Gaucher's disease. (3658134)
1987
42
Incidence, presentation, and outcome of spinal cord disease in children with systemic cancer. (3748677)
1986
43
Spinal cord ischemia following surgery for aortoiliac occlusive disease. (6502845)
1984
44
Spinal cord glioma following irradiation for Hodgkin's disease. (7370950)
1980
45
A pathological survey of 41 cases of acute intrinsic spinal cord disease. (479912)
1979
46
Spinal cord disease in the horse. (618720)
1978
47
Spinal cord disease in hereditary spherocytosis: report of two cases with a hypothesized common mechanism for neurologic and red cell abnormalities. (949548)
1976
48
Hereditary sensory neuropathy with spinal cord disease. (14032261)
1963
49
Herniation of thoracic intervertebral discs with spinal cord compression in kyphosis dorsalis juvenilis (Scheuermann's disease); case report. (13163735)
1954
50
On a Case of Early Disseminated Myelitis occurring in the Exanthem Stage of Measles and Fatal on the eleventh day of that Disease: Report on the Microscopical Examination of the Spinal Cord. (20896716)
1887

Genetic Variations for Spinal Cord Disease

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Expression for genes affiliated with Spinal Cord Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Disease

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Pathways for genes affiliated with Spinal Cord Disease

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53Reactome
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Pathways related to Spinal Cord Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1SMN1, DDX20
2
Hide members
9.9GDNF, CNTN2, COL6A1

Compounds for genes affiliated with Spinal Cord Disease

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Spinal Cord Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1aminoglycosides4410.2SMN1, GDNF
2aclarubicin4410.1SMN1, SMN2
3phenylbutyrate4410.1SMN2, SMN1
4valproic acid44 49 11 2412.8SMN2, SMN1, BTD
5cysteine449.3COL6A1, CNTN2, BTD, GDNF, NAIP, AQP4
6oligonucleotide448.6AQP4, NCL, CNTN2, HBZ, GDNF, SERPINH1
7tyrosine448.5HNRNPA1, NCL, CNTN2, BTD, GDNF, SERPINH1

GO Terms for genes affiliated with Spinal Cord Disease

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16Gene Ontology
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Cellular components related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Gemini of coiled bodiesGO:09750410.0SMN2, DDX20
2spliceosomal complexGO:0056819.6SMN2, DDX20, HNRNPA1, HNRNPA1L2
3ribonucleoprotein complexGO:0305299.4HNRNPA1, NCL, IGHMBP2
4cytoplasmGO:0057378.1HNRNPA1, IFIT1, GNB1L, DDX20, IGHMBP2, LTV1

Biological processes related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spliceosomal snRNP assemblyGO:00038710.1SMN2, DDX20
2ncRNA metabolic processGO:0346609.8SMN2, DDX20

Molecular functions related to Spinal Cord Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037238.9SMN2, IGHMBP2, NCL, IFIT1, HNRNPA1, HNRNPA1L2

Products for genes affiliated with Spinal Cord Disease

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Sources for Spinal Cord Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet