MCID: SPN042
MIFTS: 40

Spinal Cord Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma 12 51 14
Ependymal Neoplasm of the Spinal Cord 12
Ependymoma of Spinal Cord 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5503
NCIt 46 C3875
SNOMED-CT 64 254949006
UMLS 69 C0238432

Summaries for Spinal Cord Ependymoma

Disease Ontology : 12 A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to neurofibromatosis, type iv, of riccardi and myxopapillary ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Neuroscience and Glioblastoma Multiforme. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are Increased proliferation and endocrine/exocrine gland

Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 30.3 MEN1 NF1 NF2
2 myxopapillary ependymoma 30.1 GFAP HOXB13
3 adult spinal cord ependymoma 12.2
4 multiple endocrine neoplasia, type i 11.1
5 ependymoma 10.7
6 spinal cord glioma 10.5 HOXB13 RBM10
7 neurofibromatosis, familial spinal 10.4 NF1 NF2
8 cerebral convexity meningioma 10.4 GFAP NF2
9 intraventricular meningioma 10.4 GFAP NF2
10 cornea cancer 10.4 GFAP NF2
11 rhabdoid meningioma 10.4 GFAP NF2
12 spinal cancer 10.3 GFAP HOXB13 NF2
13 benign ependymoma 10.3 EPB41L3 GFAP NF2
14 gangliocytoma 10.3 GFAP RBFOX3
15 malignant ependymoma 10.3 EPB41 GFAP NF2
16 gliofibroma 10.3 GFAP NF1
17 clear cell ependymoma 10.3 EPB41L3 GFAP NF2
18 cerebellopontine angle tumor 10.3 GFAP JAG1 NF2
19 neurofibrosarcoma 10.3 NF1 NF2
20 chordoid glioma 10.3 GFAP NF2
21 neurofibromatosis, type ii 10.3 EPB41L3 NF1 NF2
22 plexiform schwannoma 10.2 GFAP NF1 NF2
23 atypical neurofibroma 10.2 GFAP NF1 NF2
24 organ system benign neoplasm 10.2 MEN1 NF1 NF2
25 neurilemmoma 10.2 GFAP NF1 NF2
26 autosomal genetic disease 10.2 MEN1 NF1 NF2
27 discrete subaortic stenosis 10.2 CD1A NOTCH1
28 pilocytic astrocytoma of cerebellum 10.2 MAPK3 NF1
29 nervous system cancer 10.2 GFAP NF1 NF2
30 autosomal dominant disease 10.1 MEN1 NF1 NF2
31 brain germinoma 10.1 GFAP NF1 RBFOX3
32 nodular regenerative hyperplasia 10.1 JAG1 NOTCH1
33 cerebral ventricle cancer 10.0 GFAP RBFOX3
34 tanycytic ependymoma 10.0 GFAP MEN1 NF2 RBFOX3
35 hydrarthrosis 10.0 AQP1 ENSG00000250424 MAPK3
36 cerebrum cancer 9.9 GFAP RBFOX3
37 multiple sclerosis 9.8
38 hydrocephalus 9.8
39 cervical dystonia 9.8
40 neurogenic bladder 9.8
41 cervicitis 9.8
42 syringomyelia 9.8
43 dystonia 9.8
44 paraplegia 9.8
45 meningioma, familial 9.8 EPB41L3 GFAP MEN1 NF1 NF2

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:



Diseases related to Spinal Cord Ependymoma

Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 MEN1 NF2

MGI Mouse Phenotypes related to Spinal Cord Ependymoma:

43 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.2 HOXB13 EPB41L3 JAG1 EPHB3 MAPK3 AQP1
2 mortality/aging MP:0010768 10.18 AQP1 HIC1 EPB41 EPB41L3 JAG1 EPHB3
3 digestive/alimentary MP:0005381 10.15 JAG1 EPHB3 GFAP MAPK3 HIC1 MEN1
4 craniofacial MP:0005382 10.11 JAG1 EPHB3 MAPK3 HIC1 MEN1 NOTCH1
5 embryo MP:0005380 10.08 HIC1 HOXB13 JAG1 NF2 MEN1 NOTCH1
6 hearing/vestibular/ear MP:0005377 10.03 JAG1 EPHB3 MAPK3 HIC1 AQP1 NOTCH1
7 nervous system MP:0003631 10.03 AQP1 HIC1 HOXB13 EPB41L3 JAG1 EPHB3
8 liver/biliary system MP:0005370 10.01 EPB41 JAG1 MAPK3 MEN1 NOTCH1 NF1
9 neoplasm MP:0002006 9.92 EPB41L3 MAPK3 HIC1 MEN1 NOTCH1 NF1
10 normal MP:0002873 9.76 HIC1 EPB41L3 JAG1 GFAP NOTCH1 RASSF1
11 renal/urinary system MP:0005367 9.5 AQP1 EPB41 JAG1 EPHB3 NF2 NOTCH1
12 vision/eye MP:0005391 9.23 AQP1 JAG1 EPHB3 GFAP NOTCH1 NF1

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
Lapatinib Approved March 2007, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
6 Alkylating Agents Phase 2
7 Protein Kinase Inhibitors Phase 2
8 Angiogenesis Inhibitors Phase 2
9 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma Unknown status NCT00826241 Phase 2 Temozolomide;Lapatinib
2 Carboplatin and Bevacizumab for Recurrent Ependymoma Recruiting NCT01295944 Phase 2 Carboplatin;Bevacizumab

Search NIH Clinical Center for Spinal Cord Ependymoma

Genetic Tests for Spinal Cord Ependymoma

Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

38
Spinal Cord

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show all 44)
# Title Authors Year
1
Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. ( 28104525 )
2017
2
LncRNA LINC00880 promotes cell proliferation, migration and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. ( 29215699 )
2017
3
Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. ( 28667596 )
2017
4
Spinal cord ependymoma: a review of the literature and case series of ten patients. ( 27154165 )
2016
5
Microsurgical resection of intramedullary spinal cord ependymoma. ( 25175587 )
2014
6
Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. ( 24982562 )
2014
7
Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. ( 24570818 )
2014
8
Spinal cord ependymoma in children--results of postoperative radiotherapy. ( 23490267 )
2013
9
Giant spinal cord ependymoma with CSF spread. ( 23008221 )
2012
10
Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. ( 23547427 )
2012
11
Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. ( 26016400 )
2012
12
Multiple sclerosis coexisting with spinal cord ependymoma: a case report. ( 23126220 )
2012
13
Surgical technique and outcomes in the treatment of spinal cord ependymomas: part II: myxopapillary ependymoma. ( 21099714 )
2011
14
Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. ( 20224707 )
2010
15
TENS and FES for sensory impairment and gait dysfunction following removal of spinal cord ependymoma--a case report. ( 19387998 )
2009
16
Total removal of cervicothoracic intramedullary 160-mm-long spinal cord ependymoma: a rare case report. ( 21686716 )
2009
17
Outcome predictors in the management of spinal cord ependymoma. ( 16865377 )
2007
18
Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. ( 17549184 )
2006
19
Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog. ( 16498832 )
2006
20
Spinal cord ependymoma: radical surgical resection and outcome. ( 12879876 )
2003
21
Spinal cord ependymoma: radical surgical resection and outcome. ( 12383361 )
2002
22
Etoposide for recurrent spinal cord ependymoma. ( 11971113 )
2002
23
Spinal cord ependymoma presenting with acute paraplegia due to tumoral bleeding. ( 11105838 )
2000
24
Special feature: pathological case of the month. Diagnosis and discussion: neurofibromatosis 2 with bilateral vestibular schwannomas and spinal cord ependymoma. ( 10980805 )
2000
25
Surgical outcome of intramedullary spinal cord ependymoma. ( 10352743 )
1999
26
Diagnosis of spinal cord ependymoma and astrocytic tumours with magnetic resonance imaging. ( 10833579 )
1999
27
Lipidized (foamy) tumor cells in a spinal cord ependymoma with collagenous metaplasia. ( 9560021 )
1998
28
Frequent type 2 neurofibromatosis gene transcript mutations in sporadic intramedullary spinal cord ependymomas. ( 8805149 )
1996
29
Spinal cord ependymoma: a positron emission tomographic study with (11C-methyl)-L-methionine. ( 8773278 )
1996
30
Giant spinal cord ependymoma in a child. Case report. ( 8913964 )
1996
31
Cervical dystonia due to spinal cord ependymoma: involvement of cervical cord segments in the pathogenesis of dystonia. ( 7565833 )
1995
32
Papilloedema and hydrocephalus in spinal cord ependymoma. ( 8199121 )
1994
33
The pathogenesis of syringomyelia in spinal cord ependymoma. ( 7889696 )
1994
34
Intramedullary abscess associated with a spinal cord ependymoma: case report. ( 1738441 )
1992
35
Postoperative radiotherapy in the management of spinal cord ependymoma. ( 2013772 )
1991
36
Spinal cord ependymoma in two young dogs. ( 3051647 )
1988
37
A case of malignant spinal cord ependymoma in association with a duplication of part of the long arm of chromosome 12. ( 3989836 )
1985
38
Thoracic spinal cord ependymoma presenting with ejaculatory failure. Case report. ( 7054411 )
1982
39
Flaccid neurogenic bladder as a presenting symptom of spinal cord ependymoma. ( 513236 )
1979
40
Spinal cord ependymoma in a dog. ( 245206 )
1977
41
Rapid arteriovenous shunting in a spinal cord ependymoma. Case report. ( 1271096 )
1976
42
A huge intramedullary spinal cord ependymoma with complete recovery following total excision. ( 1238917 )
1975
43
Repeated "occult" spinal subarachnoid hemorrhage and spinal cord ependymoma. ( 4854114 )
1974
44
Rupture of spinal cord ependymoma. Case report. ( 4743575 )
1973

Variations for Spinal Cord Ependymoma

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Pathways for Spinal Cord Ependymoma

Pathways related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 GFAP NF1 NF2 NOTCH1 RBFOX3
2 11.54 MAPK3 NF1 NF2
3 10.51 JAG1 NOTCH1
4 10.39 JAG1 NOTCH1
5 10.32 EPB41 MAPK3 NF1

GO Terms for Spinal Cord Ependymoma

Cellular components related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical part of cell GO:0045177 9.13 AQP1 JAG1 NF2
2 adherens junction GO:0005912 8.8 JAG1 NF2 NOTCH1

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.8 MEN1 NF1 NF2 NOTCH1
2 regulation of cell proliferation GO:0042127 9.73 JAG1 NF1 NF2 NOTCH1
3 angiogenesis GO:0001525 9.71 EPHB3 HOXB13 JAG1 NOTCH1
4 negative regulation of cell proliferation GO:0008285 9.65 MEN1 NF1 NF2 NOTCH1 RBM10
5 negative regulation of cell-matrix adhesion GO:0001953 9.57 NF1 NF2
6 water transport GO:0006833 9.56 AQP1 ENSG00000250424
7 negative regulation of cell-substrate adhesion GO:0010812 9.55 MEN1 NOTCH1
8 negative regulation of stem cell differentiation GO:2000737 9.54 JAG1 NOTCH1
9 ammonium transmembrane transport GO:0072488 9.52 AQP1 ENSG00000250424
10 response to muramyl dipeptide GO:0032495 9.51 JAG1 NOTCH1
11 negative regulation of oligodendrocyte differentiation GO:0048715 9.48 NF1 NOTCH1
12 cardiac septum morphogenesis GO:0060411 9.46 JAG1 NOTCH1
13 pulmonary valve morphogenesis GO:0003184 9.37 JAG1 NOTCH1
14 Notch signaling involved in heart development GO:0061314 9.32 JAG1 NOTCH1
15 Bergmann glial cell differentiation GO:0060020 9.16 GFAP MAPK3
16 distal tubule development GO:0072017 8.96 JAG1 NOTCH1
17 carbon dioxide transmembrane transport GO:0035378 8.62 AQP1 ENSG00000250424

Molecular functions related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.56 EPB41 EPB41L3 GFAP JAG1
2 structural constituent of cytoskeleton GO:0005200 9.54 EPB41 EPB41L3 GFAP
3 cytoskeletal protein binding GO:0008092 9.33 EPB41 EPB41L3 NF2
4 water channel activity GO:0015250 9.32 AQP1 ENSG00000250424
5 ammonium transmembrane transporter activity GO:0008519 8.96 AQP1 ENSG00000250424
6 carbon dioxide transmembrane transporter activity GO:0035379 8.62 AQP1 ENSG00000250424

Sources for Spinal Cord Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....