MCID: SPN185
MIFTS: 30

Spinal Cord Infarction malady

Neuronal diseases category

Summaries for Spinal Cord Infarction

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43NINDS, 32MalaCards
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NINDS:43 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards: Spinal Cord Infarction, also known as acute infarction of spinal cord, is related to antiphospholipid syndrome and patent foramen ovale. An important gene associated with Spinal Cord Infarction is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Selenium Pathway and Complement and coagulation cascades. The compounds coumarins and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Classifications for Spinal Cord Infarction

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43NINDS, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spinal cord infarction 43
acute infarction of spinal cord 60


Related Diseases for Spinal Cord Infarction

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17GeneCards, 18GeneDecks
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Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1antiphospholipid syndrome30.3APOH, F5, MTHFR, F2, SERPINC1
2patent foramen ovale30.1F5
3nephrotic syndrome30.1SERPINC1
4myocardial infarction30.1F5, MTHFR, SERPINC1
5hypertension30.1F5, MTHFR, F2
6cervicitis10.8
7aortic aneurysm10.4
8meningitis10.4
9paraplegia10.4
10spinal cord disease10.4
11arteriovenous fistula10.3
12angina pectoris10.3
13arteriovenous malformation10.3
14cerebritis10.3
15congenital afibrinogenemia10.3
16cardiac tamponade10.1
17intracranial embolism10.1
18pulmonary edema10.1
19sickle cell anemia10.1
20spondylosis10.1
21ischemic neuropathy10.1
22anterior spinal artery syndrome10.1
23spinal stenosis10.1
24dissecting aortic aneurysm10.1
25abdominal aortic aneurysm10.1
26pineal region choriocarcinoma10.1
27mesenteric vascular occlusion10.1
28spinal cord sarcoma10.1
29ischemic optic neuropathy10.1
30thoracic aortic aneurysm10.1
31infarct of liver10.1
32aortic disease10.1
33cholecystitis10.1
34cholesterol embolism10.1
35choriocarcinoma10.1
36encephalitis10.1
37hydrocephalus10.1
38malignant glioma10.1
39malignant hypertension10.1
40neuropathy10.1
41sarcoma10.1
42spinal cord glioma10.1
43sickle cell disease10.1
44fibrocartilaginous embolism10.1
45thrombophlebitis10.0APOH
46retinal artery occlusion10.0APOH
47ovarian hyperstimulation syndrome10.0F5
48purpura10.0SERPINC1
49branch retinal artery occlusion10.0F5
50acute myocardial infarction10.0SERPINC1

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to spinal cord infarction

Clinical Features for Spinal Cord Infarction

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Drugs & Therapeutics for Spinal Cord Infarction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spinal Cord Infarction

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Anatomical Context for Spinal Cord Infarction

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32MalaCards
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MalaCards organs/tissues related to Spinal Cord Infarction:

32
Spinal cord

Animal Models for Spinal Cord Infarction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spinal Cord Infarction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5F5, MTHFR, F2, SERPINC1, APOH
2MP:00053767.2SERPINC1, F2, MTHFR, F5, APOH

Publications for Spinal Cord Infarction

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Genetic Variations for Spinal Cord Infarction

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Expression for genes affiliated with Spinal Cord Infarction

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for genes affiliated with Spinal Cord Infarction

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN
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Compounds for genes affiliated with Spinal Cord Infarction

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Spinal Cord Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1coumarins4410.4APOH
2monoethylglycinexylidide4410.1F5
3warfarin44 49 11 2413.0APOH, SERPINC1
4aprotinin44 1110.7SERPINC1, F5
5certoparin449.6F2, SERPINC1
6heparin44 28 11 2412.6MTHFR, APOH
7polybrene449.6SERPINC1, F2
8nafamostat mesilate449.5F5, SERPINC1
9batroxobin449.5F2, F5
10fibrinopeptide a449.5F2, SERPINC1
11hepaplastin449.4SERPINC1, F2
12eltrombopag49 1110.3SERPINC1, F5
13rivaroxaban44 1110.3SERPINC1, F2
14kaolin449.3APOH, F5, F2
15dextran sulfate449.3APOH, SERPINC1, F5
16inogatran449.3F5, SERPINC1, F2
17hirugen449.3F5, F2, SERPINC1
18ecarin449.3SERPINC1, F5, F2
19spectrozyme449.2F2, SERPINC1, F5
20danaparoid449.2F2, F5, SERPINC1
21ancrod449.2F5, F2, SERPINC1
22ximelagatran44 1110.2SERPINC1, F2, F5
23heparinoids449.2F2, SERPINC1, F5
24fondaparinux449.2F2, SERPINC1, F5
25bivalirudin44 1110.2F2, SERPINC1, F5
26argatroban44 1110.2F5, F2, SERPINC1
27desogestrel44 1110.2F5, F2, SERPINC1
28phosphatidylethanolamine44 1110.2F5, APOH, F2
29protamine sulfate449.2F2, SERPINC1, F5
30gestodene44 1110.2SERPINC1, F2, F5
31ristocetin449.2F5, F2, SERPINC1
32levonorgestrel44 59 28 1112.2F5, SERPINC1, F2
33coumarin44 2 49 2412.2F2, F5, SERPINC1
34desmopressin44 59 28 1112.2SERPINC1, F2, F5
35hirudin449.2F5, SERPINC1, F2
36pge1449.2F5, APOH, F2
37protamine449.1SERPINC1, F2, F5
38dermatan sulfate449.1SERPINC1, F2, F5
39polyethylene glycol449.0SERPINC1, F5, F2
40organon449.0F2, SERPINC1
41vitamin b12449.0APOH, F5, MTHFR
42uric acid44 249.9F5, APOH, MTHFR
43kininogen448.8F5, APOH, SERPINC1, F2
44p002448.7APOH, F5, MTHFR
45folate448.5MTHFR, APOH, F5, SERPINC1
46homocysteine44 249.0SERPINC1, F2, MTHFR, F5, APOH
47aspirin44 49 28 2411.0F2, F5, APOH, MTHFR, SERPINC1
48fibrinogen448.0APOH, F5, SERPINC1, F2, MTHFR
49creatinine447.9F5, APOH, MTHFR, F2, SERPINC1
50estrogen447.9SERPINC1, APOH, F2, MTHFR, F5

GO Terms for genes affiliated with Spinal Cord Infarction

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16Gene Ontology
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Cellular components related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4SERPINC1, F2, F5, APOH

Biological processes related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.5F2, APOH
2positive regulation of blood coagulationGO:0301949.4F2, APOH
3blood coagulation, intrinsic pathwayGO:0075979.3APOH, F2
4blood circulationGO:0080158.8MTHFR, F5
5blood coagulationGO:0075968.8SERPINC1, F2, F5

Products for genes affiliated with Spinal Cord Infarction

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Sources for Spinal Cord Infarction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet