MCID: SPN185
MIFTS: 42

Spinal Cord Infarction malady

Neuronal diseases category

Summaries for Spinal Cord Infarction

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45NINDS, 34MalaCards
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NINDS:45 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards: Spinal Cord Infarction, also known as acute infarction of spinal cord, is related to afibrinogenemia and patent foramen ovale. An important gene associated with Spinal Cord Infarction is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Selenium Pathway and Hemostasis. The compounds certoparin and polybrene have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and liver, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Spinal Cord Infarction

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Sources:
45NINDS, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

spinal cord infarction 45
acute infarction of spinal cord 63


Related Diseases for Spinal Cord Infarction

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1afibrinogenemia30.4F5, F2
2patent foramen ovale30.3F5
3myocardial infarction30.1SERPINC1, MTHFR, F5
4hypertension30.1F5, MTHFR, F2
5antiphospholipid syndrome30.0MTHFR, SERPINC1, APOH, F2, F5
6venous thrombosis30.0F2, APOH, SERPINC1, MTHFR, F5
7cervicitis10.8
8fibrocartilaginous embolism10.6
9aneurysm10.5
10aortic aneurysm10.4
11meningitis10.4
12paraplegia10.4
13arteriovenous fistula10.4
14angina pectoris10.3
15congenital afibrinogenemia10.3
16cerebritis10.3
17meningococcal meningitis10.3
18cardiac tamponade10.1
19sickle cell anemia10.1
20spondylosis10.1
21anterior spinal artery syndrome10.1
22pineal region choriocarcinoma10.1
23abdominal aortic aneurysm10.1
24pulmonary edema10.1
25arteriovenous malformation10.1
26mesenteric vascular occlusion10.1
27aortic disease10.1
28cholecystitis10.1
29cholesterol embolism10.1
30choriocarcinoma10.1
31encephalitis10.1
32hydrocephalus10.1
33malignant hypertension10.1
34nephrotic syndrome10.1
35neuropathy10.1
36sarcoma10.1
37sickle cell disease10.1
38myelodysplastic syndromes10.1
39thrombophlebitis10.1APOH
40retinal artery occlusion10.1APOH
41coronary thrombosis10.1SERPINC1
42purpura10.1SERPINC1
43hypersplenism10.1F2
44hemophilia b10.1F2
45branch retinal artery occlusion10.1F5
46factor xii deficiency10.1F5
47factor viii deficiency10.1F5
48sneddon syndrome10.1APOH, SERPINC1
49transient cerebral ischemia10.0APOH, MTHFR
50eclampsia10.0SERPINC1, MTHFR

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to spinal cord infarction

Symptoms for Spinal Cord Infarction

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Drugs & Therapeutics for Spinal Cord Infarction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Spinal Cord Infarction

Drug clinical trials:

Search ClinicalTrials for Spinal Cord Infarction

Search NIH Clinical Center for Spinal Cord Infarction

Search CenterWatch for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

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Anatomical Context for Spinal Cord Infarction

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Sources:
34MalaCards
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MalaCards organs/tissues related to Spinal Cord Infarction:

34
Spinal cord, Kidney, Liver, Pineal

Animal Models for Spinal Cord Infarction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Spinal Cord Infarction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0F5, MTHFR, SERPINC1, F2
2MP:00053767.4F5, MTHFR, SERPINC1, APOH, F2
3MP:00107687.2F2, APOH, SERPINC1, MTHFR, F5

Publications for Spinal Cord Infarction

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Sources:
53PubMed
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Articles related to Spinal Cord Infarction:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Unilateral posterior cervical spinal cord infarction due to spontaneous vertebral artery dissection. (24090478)
2013
2
Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention. (24355157)
2013
3
Dural arteriovenous fistula at the craniocervical junction mimicking acute brainstem and spinal cord infarction. (23753962)
2013
4
Clinical features and outcomes of spinal cord infarction following vertebral artery dissection: a systematic review of the literature. (23562138)
2013
5
Spinal cord infarction in diabetic pregnancy: a case report. (23855498)
2013
6
Survival following spinal cord infarction. (23528791)
2013
7
Spinal cord infarction remote from maximal compression in a patient with Morquio syndrome. (22656250)
2012
8
Restricted diffusion in spinal cord infarction demonstrated by magnetic resonance line scan diffusion imaging. (22033988)
2012
9
Delayed post-traumatic spinal cord infarction in an adult after minor head and neck trauma: a case report. (22992313)
2012
10
Successful management of aortic thrombi resulting in spinal cord infarction in a patient with antiphospholipid antibody syndrome and acute cholecystitis. (23754914)
2011
11
Spinal cord infarction due to fibrocartilaginous embolization: the role of diffusion weighted imaging and short-tau inversion recovery sequences. (20299698)
2010
12
Spontaneous spinal cord infarction secondary to embolism from an aortic aneurysm mimicking as cauda equina due to disc prolapse: a case report. (19829969)
2009
13
A case of spinal cord infarction following lumbar transforaminal epidural steroid injection: MR imaging and angiographic findings. (19369604)
2009
14
Anterior spinal cord infarction caused by fibrocartilaginous embolism. (18627484)
2009
15
Cocaine-induced spinal cord infarction. (18716023)
2008
16
Spinal cord infarction after decompressive laminectomy for spontaneous spinal epidural hematoma--case report. (17652921)
2007
17
Spinal cord infarction secondary to cocaine use. (17167348)
2007
18
Traumatic spinal cord infarction in a child: case report and review of literature. (17445627)
2007
19
Spinal cord infarction after weight lifting. (16635712)
2006
20
Spinal cord infarction after weight lifting (Am J Emerg Med. 2006 May;24(3):352-5). (16984864)
2006
21
Embolic spinal cord infarction as a presentation of abdominal aortic aneurysm. (15684355)
2005
22
Spinal cord infarction demonstrated by diffusion-weighted magnetic resonance imaging. (15925784)
2005
23
Spinal cord infarction complicating acute hydrocephalus secondary to a colloid cyst of the third ventricle. Case report. (16122026)
2005
24
Spinal cord infarction following cervical transforaminal epidural injection: a case report. (15897816)
2005
25
Multishot diffusion-weighted imaging features in spinal cord infarction. (15905774)
2005
26
Magnetic resonance imaging findings in spinal cord infarction in three small breed dogs. (15869150)
2005
27
Diffusion-weighted MRI of spinal cord infarction--high resolution imaging and time course of diffusion abnormality. (15258783)
2004
28
Fibrocartilaginous embolism--an uncommon cause of spinal cord infarction: a case report and review of the literature. (14970983)
2004
29
Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history. (15176568)
2004
30
Magnetic resonance imaging as a guide in the diagnosis and follow-up of spinal cord infarction. (12716006)
2003
31
Spinal cord infarction following central-line insertion. (12739841)
2003
32
Case report: spinal cord infarction demonstrated on diffusion-weighted MR imaging with a single-shot fast spin-echo sequence. (12794608)
2003
33
Post-epidural analgesia spinal cord infarction: MRI correlation. (11939953)
2002
34
Giant cell arteritis complicated by spinal cord infarction: a therapeutic dilemma. (12136920)
2002
35
Vertebra, rib and spinal cord infarction caused by probable fibrocartilaginous embolism. (11490109)
2001
36
Spinal cord infarction and recurrent venous thrombosis in association with estrogens and the 20210A allele of the prothrombin gene]. (11742625)
2001
37
Spinal cord infarction mimicking angina pectoris. (11075751)
2000
38
MRI of spinal cord infarction. (10851403)
2000
39
Spinal cord infarction and tetraplegia--rare complications of meningococcal meningitis. (10823108)
2000
40
Posterior thoracic spinal cord infarction: complication of thoracoabdominal aortic aneurysm. (10894998)
2000
41
Prothrombin G20210A mutation in a child with spinal cord infarction. (10356151)
1999
42
Spinal cord infarction. (9153513)
1997
43
Spinal cord infarction: varying degrees of upper and lower motoneuron dysfunction. (9237791)
1996
44
MRI diagnosis of spinal cord infarction: report of a case. (7613238)
1995
45
Spinal cord infarction associated with primary antiphospholipid syndrome in a young child. Case report. (8360745)
1993
46
MR imaging of spontaneous spinal cord infarction. (2002099)
1991
47
Giant cell arteritis with spinal cord infarction and basilar artery thrombosis. (4045490)
1985
48
Fatal spinal cord infarction caused by fibrocartilaginous embolization of the anterior spinal artery. (7429494)
1980
49
Spinal cord infarction due to minor trauma in children. (1168316)
1975
50
Spinal cord infarction associated with the sickle cell trait. (5434950)
1970

Variations for Spinal Cord Infarction

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Expression for genes affiliated with Spinal Cord Infarction

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for genes affiliated with Spinal Cord Infarction

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG, 55R&D Systems
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Pathways related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway39
9.3MTHFR, F2
2
Show member pathways
8.5F5, SERPINC1, F2
3
Show member pathways
8.5F2, SERPINC1, F5
4
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.5F5, SERPINC1, F2
5
Show member pathways
8.5F5, SERPINC1, F2

Compounds for genes affiliated with Spinal Cord Infarction

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 52PharmGKB
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Compounds related to Spinal Cord Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1certoparin469.6F2, SERPINC1
2polybrene469.5SERPINC1, F2
3hepaplastin469.5SERPINC1, F2
4fibrinopeptide a469.3F2, SERPINC1
5rivaroxaban46 1210.3SERPINC1, F2
6nafamostat mesilate469.2SERPINC1, F5
7batroxobin469.1F2, F5
8organon469.0F2, SERPINC1
9kaolin469.0APOH, F2, F5
10dextran sulfate469.0APOH, SERPINC1, F5
11coumarins469.0F5, F2, APOH
12vitamin b12469.0F5, APOH, MTHFR
13inogatran469.0F2, F5, SERPINC1
14ecarin469.0SERPINC1, F5, F2
15hirugen468.9F5, F2, SERPINC1
16spectrozyme468.9F2, F5, SERPINC1
17danaparoid468.9SERPINC1, F5, F2
18ancrod468.9F2, F5, SERPINC1
19monoethylglycinexylidide468.9F2, F5
20ximelagatran46 129.9F5, SERPINC1, F2
21heparinoids468.9F5, SERPINC1, F2
22fondaparinux468.9SERPINC1, F5, F2
23cardiolipin46 129.9F5, APOH, F2
24uric acid46 259.9F5, APOH, MTHFR
25bivalirudin46 129.9F2, SERPINC1, F5
26desogestrel46 129.9F5, SERPINC1, F2
27phosphatidylethanolamine46 129.9F5, F2, APOH
28argatroban46 129.9F2, SERPINC1, F5
29protamine sulfate468.9F5, SERPINC1, F2
30gestodene46 129.9F5, SERPINC1, F2
31ristocetin468.9F2, SERPINC1, F5
32levonorgestrel46 62 30 1211.9F2, SERPINC1, F5
33coumarin46 3 52 2511.9SERPINC1, F2, F5
34desmopressin46 62 30 1211.9F2, F5, SERPINC1
35p002468.9F5, APOH, MTHFR
36hirudin468.8F2, F5, SERPINC1
37pge1468.8F2, F5, APOH
38protamine468.8F5, SERPINC1, F2
39dermatan sulfate468.8SERPINC1, F5, F2
40aprotinin46 129.8F2, SERPINC1, F5
41polyethylene glycol468.7SERPINC1, F5, F2
42folate468.5F5, MTHFR, SERPINC1, APOH
43kininogen468.5F5, SERPINC1, APOH, F2
44warfarin46 52 25 1211.0MTHFR, F5, APOH, SERPINC1, F2
45homocysteine46 259.0F5, MTHFR, SERPINC1, APOH, F2
46aspirin46 52 30 2511.0F2, APOH, MTHFR, F5, SERPINC1
47fibrinogen468.0F5, MTHFR, APOH, SERPINC1, F2
48creatinine467.9F5, MTHFR, SERPINC1, APOH, F2
49heparin46 30 25 1210.9MTHFR, SERPINC1, APOH, F2, F5
50estrogen467.9F2, MTHFR, SERPINC1, APOH, F5

GO Terms for genes affiliated with Spinal Cord Infarction

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Sources:
17Gene Ontology
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Cellular components related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.3SERPINC1, F2
2extracellular spaceGO:0056157.8F5, SERPINC1, APOH, F2

Biological processes related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.5APOH, F2
2positive regulation of blood coagulationGO:0301949.4APOH, F2
3blood coagulation, intrinsic pathwayGO:0075979.3F2, APOH
4blood circulationGO:0080158.8F5, MTHFR
5blood coagulationGO:0075968.5F5, SERPINC1, F2

Molecular functions related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.2SERPINC1, APOH
2serine-type endopeptidase activityGO:0042529.0F5, F2

Products for genes affiliated with Spinal Cord Infarction

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Sources for Spinal Cord Infarction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet