MCID: SPN185
MIFTS: 36

Spinal Cord Infarction malady

Neuronal diseases category

Aliases & Classifications for Spinal Cord Infarction

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Spinal Cord Infarction, Aliases & Descriptions:

Name: Spinal Cord Infarction 42
 
Infarction of Spinal Cord 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Summaries for Spinal Cord Infarction

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NINDS:42 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards based summary: Spinal Cord Infarction, also known as infarction of spinal cord, is related to patent foramen ovale and afibrinogenemia. An important gene associated with Spinal Cord Infarction is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Selenium Pathway and Hemostasis. The compounds certoparin and polybrene have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and liver, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Related Diseases for Spinal Cord Infarction

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Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1patent foramen ovale30.8F5
2afibrinogenemia30.4F5, F2
3myocardial infarction29.9SERPINC1, MTHFR, F5
4antiphospholipid syndrome29.3MTHFR, SERPINC1, APOH, F2, F5
5cervicitis10.8
6fibrocartilaginous embolism10.7
7paraplegia10.5
8aneurysm10.5
9thrombophlebitis10.5APOH
10retinal artery occlusion10.5APOH
11aortic aneurysm10.5
12meningitis10.5
13arteriovenous fistula10.4
14coronary thrombosis10.4SERPINC1
15purpura10.4SERPINC1
16hypersplenism10.3F2
17hemophilia b10.3F2
18angina pectoris10.3
19arteriovenous malformation10.3
20cerebritis10.3
21meningococcal meningitis10.3
22branch retinal artery occlusion10.3F5
23factor xiii deficiency10.3F5
24factor viii deficiency10.3F5
25sneddon syndrome10.2APOH, SERPINC1
26eclampsia10.2SERPINC1, MTHFR
27transient cerebral ischemia10.2APOH, MTHFR
28vascular disease10.2SERPINC1, APOH
29myelodysplastic syndrome10.2
30polycythemia vera10.2
31sickle cell anemia10.2
32acne10.2
33hydrocephalus10.2
34ischemic optic neuropathy10.2
35spondylosis10.2
36cardiac tamponade10.2
37anterior spinal artery syndrome10.2
38pineal region choriocarcinoma10.2
39abdominal aortic aneurysm10.2
40pulmonary edema10.2
41cadasil10.2
42mesenteric vascular occlusion10.2
43aortic disease10.2
44cholecystitis10.2
45cholesterol embolism10.2
46choriocarcinoma10.2
47encephalitis10.2
48malignant hypertension10.2
49nephrotic syndrome10.2
50neuropathy10.2

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to spinal cord infarction

Symptoms for Spinal Cord Infarction

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Drugs & Therapeutics for Spinal Cord Infarction

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Drug clinical trials:

Search ClinicalTrials for Spinal Cord Infarction

Search NIH Clinical Center for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

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Anatomical Context for Spinal Cord Infarction

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MalaCards organs/tissues related to Spinal Cord Infarction:

31
Spinal cord, Kidney, Liver, Lung, Pineal

Animal Models for Spinal Cord Infarction or affiliated genes

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MGI Mouse Phenotypes related to Spinal Cord Infarction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0F5, MTHFR, SERPINC1, F2
2MP:00053767.4F5, MTHFR, SERPINC1, APOH, F2
3MP:00107687.2F2, APOH, SERPINC1, MTHFR, F5

Publications for Spinal Cord Infarction

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Articles related to Spinal Cord Infarction:

(show top 50)    (show all 209)
idTitleAuthorsYear
1
Spinal cord infarction as a complication of hemodialysis. (25459747)
2015
2
A case of spinal cord infarction caused by polycythemia vera. (25900285)
2015
3
Back pain--an ominous harbinger of spinal cord infarction. (25668920)
2014
4
Delayed presentation of cerebellar and spinal cord infarction as a complication of computed tomography-guided transthoracic lung biopsy: a case report. (25113016)
2014
5
Spinal cord infarction: a rare cause of paraplegia. (24966260)
2014
6
Unilateral posterior cervical spinal cord infarction due to spontaneous vertebral artery dissection. (24090478)
2013
7
Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention. (24355157)
2013
8
Dural arteriovenous fistula at the craniocervical junction mimicking acute brainstem and spinal cord infarction. (23753962)
2013
9
Clinical features and outcomes of spinal cord infarction following vertebral artery dissection: a systematic review of the literature. (23562138)
2013
10
Spinal cord infarction in diabetic pregnancy: a case report. (23855498)
2013
11
Spinal cord infarction remote from maximal compression in a patient with Morquio syndrome. (22656250)
2012
12
Restricted diffusion in spinal cord infarction demonstrated by magnetic resonance line scan diffusion imaging. (22033988)
2012
13
Delayed post-traumatic spinal cord infarction in an adult after minor head and neck trauma: a case report. (22992313)
2012
14
Spinal cord infarction due to fibrocartilaginous embolization: the role of diffusion weighted imaging and short-tau inversion recovery sequences. (20299698)
2010
15
Spontaneous spinal cord infarction secondary to embolism from an aortic aneurysm mimicking as cauda equina due to disc prolapse: a case report. (19829969)
2009
16
A case of spinal cord infarction following lumbar transforaminal epidural steroid injection: MR imaging and angiographic findings. (19369604)
2009
17
Cocaine-induced spinal cord infarction. (18716023)
2008
18
Spinal cord infarction after decompressive laminectomy for spontaneous spinal epidural hematoma--case report. (17652921)
2007
19
Spinal cord infarction secondary to cocaine use. (17167348)
2007
20
Traumatic spinal cord infarction in a child: case report and review of literature. (17445627)
2007
21
Spinal cord infarction after weight lifting. (16635712)
2006
22
Spinal cord infarction after weight lifting (Am J Emerg Med. 2006 May;24(3):352-5). (16984864)
2006
23
Embolic spinal cord infarction as a presentation of abdominal aortic aneurysm. (15684355)
2005
24
Spinal cord infarction demonstrated by diffusion-weighted magnetic resonance imaging. (15925784)
2005
25
Spinal cord infarction complicating acute hydrocephalus secondary to a colloid cyst of the third ventricle. Case report. (16122026)
2005
26
Spinal cord infarction following cervical transforaminal epidural injection: a case report. (15897816)
2005
27
Multishot diffusion-weighted imaging features in spinal cord infarction. (15905774)
2005
28
Magnetic resonance imaging findings in spinal cord infarction in three small breed dogs. (15869150)
2005
29
Diffusion-weighted MRI of spinal cord infarction--high resolution imaging and time course of diffusion abnormality. (15258783)
2004
30
Fibrocartilaginous embolism--an uncommon cause of spinal cord infarction: a case report and review of the literature. (14970983)
2004
31
Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history. (15176568)
2004
32
Magnetic resonance imaging as a guide in the diagnosis and follow-up of spinal cord infarction. (12716006)
2003
33
Spinal cord infarction following central-line insertion. (12739841)
2003
34
Case report: spinal cord infarction demonstrated on diffusion-weighted MR imaging with a single-shot fast spin-echo sequence. (12794608)
2003
35
Post-epidural analgesia spinal cord infarction: MRI correlation. (11939953)
2002
36
Giant cell arteritis complicated by spinal cord infarction: a therapeutic dilemma. (12136920)
2002
37
Vertebra, rib and spinal cord infarction caused by probable fibrocartilaginous embolism. (11490109)
2001
38
Spinal cord infarction mimicking angina pectoris. (11075751)
2000
39
MRI of spinal cord infarction. (10851403)
2000
40
Spinal cord infarction and tetraplegia--rare complications of meningococcal meningitis. (10823108)
2000
41
Posterior thoracic spinal cord infarction: complication of thoracoabdominal aortic aneurysm. (10894998)
2000
42
Prothrombin G20210A mutation in a child with spinal cord infarction. (10356151)
1999
43
Acute spinal cord infarction: vascular steal in arteriovenous malformation. (10511344)
1999
44
MRI diagnosis of spinal cord infarction: report of a case. (7613238)
1995
45
MR imaging of spontaneous spinal cord infarction. (2002099)
1991
46
Giant cell arteritis with spinal cord infarction and basilar artery thrombosis. (4045490)
1985
47
Fatal spinal cord infarction caused by fibrocartilaginous embolization of the anterior spinal artery. (7429494)
1980
48
Spinal cord infarction due to minor trauma in children. (1168316)
1975
49
Spinal cord infarction associated with the sickle cell trait. (5434950)
1970
50
SPINAL-CORD INFARCTION DUE TO AORTIC TRAUMA. (14160229)
1964

Variations for Spinal Cord Infarction

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Expression for genes affiliated with Spinal Cord Infarction

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Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for genes affiliated with Spinal Cord Infarction

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Pathways related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway36
9.3MTHFR, F2
2
Show member pathways
8.5F5, SERPINC1, F2
3
Show member pathways
8.5F2, SERPINC1, F5
4
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.5F5, SERPINC1, F2
5
Show member pathways
8.5F5, SERPINC1, F2

Compounds for genes affiliated with Spinal Cord Infarction

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Compounds related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1certoparin439.6SERPINC1, F2
2polybrene439.5SERPINC1, F2
3hepaplastin439.4F2, SERPINC1
4fibrinopeptide a439.3F2, SERPINC1
5rivaroxaban43 1210.3SERPINC1, F2
6nafamostat mesilate439.2SERPINC1, F5
7monoethylglycinexylidide439.2F2, F5
8organon439.0SERPINC1, F2
9kaolin439.0F2, APOH, F5
10dextran sulfate439.0F5, SERPINC1, APOH
11coumarins439.0F2, APOH, F5
12vitamin b12439.0APOH, MTHFR, F5
13inogatran439.0F5, SERPINC1, F2
14hirugen439.0F5, SERPINC1, F2
15ecarin438.9F5, SERPINC1, F2
16spectrozyme438.9F2, SERPINC1, F5
17danaparoid438.9F2, SERPINC1, F5
18ximelagatran43 129.9F2, SERPINC1, F5
19batroxobin438.9F2, F5
20ancrod438.9F2, SERPINC1, F5
21heparinoids438.9F2, SERPINC1, F5
22fondaparinux438.9F5, SERPINC1, F2
23cardiolipin43 129.9F5, APOH, F2
24uric acid43 249.9F5, MTHFR, APOH
25bivalirudin43 129.9F2, SERPINC1, F5
26desogestrel43 129.9F2, SERPINC1, F5
27phosphatidylethanolamine43 129.9F5, APOH, F2
28argatroban43 129.9F2, SERPINC1, F5
29protamine sulfate438.9F2, SERPINC1, F5
30gestodene43 129.9F5, SERPINC1, F2
31ristocetin438.9F5, SERPINC1, F2
32levonorgestrel43 59 28 1211.9F2, SERPINC1, F5
33desmopressin43 59 28 1211.9F2, SERPINC1, F5
34coumarin43 2 49 2411.9F2, SERPINC1, F5
35p002438.9APOH, MTHFR, F5
36hirudin438.8F2, SERPINC1, F5
37pge1438.8F2, APOH, F5
38protamine438.8F5, SERPINC1, F2
39dermatan sulfate438.8F2, SERPINC1, F5
40aprotinin43 129.8F5, SERPINC1, F2
41polyethylene glycol438.7F2, SERPINC1, F5
42folate438.5APOH, SERPINC1, MTHFR, F5
43kininogen438.5F5, SERPINC1, APOH, F2
44warfarin43 49 24 1211.0F5, MTHFR, SERPINC1, APOH, F2
45homocysteine43 249.0F2, APOH, SERPINC1, MTHFR, F5
46aspirin43 49 28 2411.0F2, APOH, SERPINC1, MTHFR, F5
47fibrinogen438.0F2, APOH, SERPINC1, MTHFR, F5
48creatinine437.9F2, APOH, SERPINC1, MTHFR, F5
49heparin43 28 24 1210.9F5, MTHFR, SERPINC1, APOH, F2
50estrogen437.9F5, MTHFR, SERPINC1, APOH, F2

GO Terms for genes affiliated with Spinal Cord Infarction

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Cellular components related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.3SERPINC1, F2
2extracellular spaceGO:00056157.8F5, SERPINC1, APOH, F2

Biological processes related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:00519189.5APOH, F2
2positive regulation of blood coagulationGO:00301949.4APOH, F2
3blood coagulation, intrinsic pathwayGO:00075979.3F2, APOH
4blood circulationGO:00080158.8F5, MTHFR
5blood coagulationGO:00075968.5F5, SERPINC1, F2

Molecular functions related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.2SERPINC1, APOH
2serine-type endopeptidase activityGO:00042529.0F5, F2

Products for genes affiliated with Spinal Cord Infarction

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Sources for Spinal Cord Infarction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet