MCID: SPN185
MIFTS: 42

Spinal Cord Infarction malady

Neuronal diseases category

Summaries for Spinal Cord Infarction

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NINDS:43 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards based summary: Spinal Cord Infarction, also known as acute infarction of spinal cord, is related to patent foramen ovale and afibrinogenemia. An important gene associated with Spinal Cord Infarction is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Selenium Pathway and Hemostasis. The compounds certoparin and polybrene have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and liver, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Spinal Cord Infarction

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Spinal Cord Infarction, Aliases & Descriptions:

Name: Spinal Cord Infarction 43
 
Acute Infarction of Spinal Cord 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Related Diseases for Spinal Cord Infarction

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Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1patent foramen ovale30.8F5
2afibrinogenemia30.4F5, F2
3hypertension29.9F5, MTHFR, F2
4myocardial infarction29.9SERPINC1, MTHFR, F5
5antiphospholipid syndrome29.3MTHFR, SERPINC1, APOH, F2, F5
6venous thrombosis29.3F2, APOH, SERPINC1, MTHFR, F5
7cervicitis10.8
8fibrocartilaginous embolism10.7
9aneurysm10.5
10thrombophlebitis10.5APOH
11retinal artery occlusion10.5APOH
12aortic aneurysm10.5
13meningitis10.5
14paraplegia10.5
15arteriovenous fistula10.4
16coronary thrombosis10.4SERPINC1
17purpura10.4SERPINC1
18hypersplenism10.3F2
19hemophilia b10.3F2
20branch retinal artery occlusion10.3F5
21angina pectoris10.3
22congenital afibrinogenemia10.3
23arteriovenous malformation10.3
24cerebritis10.3
25meningococcal meningitis10.3
26factor xii deficiency10.3F5
27factor viii deficiency10.3F5
28sneddon syndrome10.2APOH, SERPINC1
29transient cerebral ischemia10.2APOH, MTHFR
30eclampsia10.2SERPINC1, MTHFR
31vascular disease10.2SERPINC1, APOH
32cerebrovascular disease10.2APOH, MTHFR
33hydrocephalus10.2
34ischemic optic neuropathy10.2
35myelodysplastic syndromes10.2
36sickle cell anemia10.2
37spondylosis10.2
38abdominal aortic aneurysm10.2
39cardiac tamponade10.2
40anterior spinal artery syndrome10.2
41cadasil10.2
42mesenteric vascular occlusion10.2
43pineal region choriocarcinoma10.2
44pulmonary edema10.2
45aortic disease10.2
46cholecystitis10.2
47cholesterol embolism10.2
48choriocarcinoma10.2
49encephalitis10.2
50malignant hypertension10.2

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to spinal cord infarction

Symptoms for Spinal Cord Infarction

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Drugs & Therapeutics for Spinal Cord Infarction

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Drug clinical trials:

Search ClinicalTrials for Spinal Cord Infarction

Search NIH Clinical Center for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

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Anatomical Context for Spinal Cord Infarction

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MalaCards organs/tissues related to Spinal Cord Infarction:

32
Spinal cord, Kidney, Liver, Lung, Pineal

Animal Models for Spinal Cord Infarction or affiliated genes

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MGI Mouse Phenotypes related to Spinal Cord Infarction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.0F5, MTHFR, SERPINC1, F2
2MP:00053767.4F5, MTHFR, SERPINC1, APOH, F2
3MP:00107687.2F2, APOH, SERPINC1, MTHFR, F5

Publications for Spinal Cord Infarction

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Articles related to Spinal Cord Infarction:

(show top 50)    (show all 202)
idTitleAuthorsYear
1
Delayed presentation of cerebellar and spinal cord infarction as a complication of computed tomography-guided transthoracic lung biopsy: a case report. (25113016)
2014
2
Spinal cord infarction and patent foramen ovale: is there a link? (25076895)
2014
3
Unilateral posterior cervical spinal cord infarction due to spontaneous vertebral artery dissection. (24090478)
2013
4
Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention. (24355157)
2013
5
Dural arteriovenous fistula at the craniocervical junction mimicking acute brainstem and spinal cord infarction. (23753962)
2013
6
Clinical features and outcomes of spinal cord infarction following vertebral artery dissection: a systematic review of the literature. (23562138)
2013
7
Spinal cord infarction in diabetic pregnancy: a case report. (23855498)
2013
8
Survival following spinal cord infarction. (23528791)
2013
9
Spinal cord infarction remote from maximal compression in a patient with Morquio syndrome. (22656250)
2012
10
Restricted diffusion in spinal cord infarction demonstrated by magnetic resonance line scan diffusion imaging. (22033988)
2012
11
Delayed post-traumatic spinal cord infarction in an adult after minor head and neck trauma: a case report. (22992313)
2012
12
Spinal cord infarction due to fibrocartilaginous embolization: the role of diffusion weighted imaging and short-tau inversion recovery sequences. (20299698)
2010
13
Spontaneous spinal cord infarction secondary to embolism from an aortic aneurysm mimicking as cauda equina due to disc prolapse: a case report. (19829969)
2009
14
A case of spinal cord infarction following lumbar transforaminal epidural steroid injection: MR imaging and angiographic findings. (19369604)
2009
15
Anterior spinal cord infarction caused by fibrocartilaginous embolism. (18627484)
2009
16
Cocaine-induced spinal cord infarction. (18716023)
2008
17
Spinal cord infarction after decompressive laminectomy for spontaneous spinal epidural hematoma--case report. (17652921)
2007
18
Spinal cord infarction secondary to cocaine use. (17167348)
2007
19
Traumatic spinal cord infarction in a child: case report and review of literature. (17445627)
2007
20
Spinal cord infarction after weight lifting. (16635712)
2006
21
Spinal cord infarction after weight lifting (Am J Emerg Med. 2006 May;24(3):352-5). (16984864)
2006
22
Embolic spinal cord infarction as a presentation of abdominal aortic aneurysm. (15684355)
2005
23
Spinal cord infarction demonstrated by diffusion-weighted magnetic resonance imaging. (15925784)
2005
24
Spinal cord infarction complicating acute hydrocephalus secondary to a colloid cyst of the third ventricle. Case report. (16122026)
2005
25
Spinal cord infarction following cervical transforaminal epidural injection: a case report. (15897816)
2005
26
Multishot diffusion-weighted imaging features in spinal cord infarction. (15905774)
2005
27
Magnetic resonance imaging findings in spinal cord infarction in three small breed dogs. (15869150)
2005
28
Diffusion-weighted MRI of spinal cord infarction--high resolution imaging and time course of diffusion abnormality. (15258783)
2004
29
Fibrocartilaginous embolism--an uncommon cause of spinal cord infarction: a case report and review of the literature. (14970983)
2004
30
Spinal cord infarction caused by malignant intramedullary glioma: the traps of epidemiology and travel history. (15176568)
2004
31
Magnetic resonance imaging as a guide in the diagnosis and follow-up of spinal cord infarction. (12716006)
2003
32
Spinal cord infarction following central-line insertion. (12739841)
2003
33
Case report: spinal cord infarction demonstrated on diffusion-weighted MR imaging with a single-shot fast spin-echo sequence. (12794608)
2003
34
Post-epidural analgesia spinal cord infarction: MRI correlation. (11939953)
2002
35
Giant cell arteritis complicated by spinal cord infarction: a therapeutic dilemma. (12136920)
2002
36
Vertebra, rib and spinal cord infarction caused by probable fibrocartilaginous embolism. (11490109)
2001
37
Spinal cord infarction and recurrent venous thrombosis in association with estrogens and the 20210A allele of the prothrombin gene]. (11742625)
2001
38
Spinal cord infarction mimicking angina pectoris. (11075751)
2000
39
MRI of spinal cord infarction. (10851403)
2000
40
Spinal cord infarction and tetraplegia--rare complications of meningococcal meningitis. (10823108)
2000
41
Posterior thoracic spinal cord infarction: complication of thoracoabdominal aortic aneurysm. (10894998)
2000
42
Prothrombin G20210A mutation in a child with spinal cord infarction. (10356151)
1999
43
Acute spinal cord infarction: vascular steal in arteriovenous malformation. (10511344)
1999
44
Spinal cord infarction. (9153513)
1997
45
MRI diagnosis of spinal cord infarction: report of a case. (7613238)
1995
46
MR imaging of spontaneous spinal cord infarction. (2002099)
1991
47
Fatal spinal cord infarction caused by fibrocartilaginous embolization of the anterior spinal artery. (7429494)
1980
48
Spinal cord infarction due to minor trauma in children. (1168316)
1975
49
Spinal cord infarction associated with the sickle cell trait. (5434950)
1970
50
SPINAL-CORD INFARCTION DUE TO AORTIC TRAUMA. (14160229)
1964

Variations for Spinal Cord Infarction

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Expression for genes affiliated with Spinal Cord Infarction

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Expression patterns in normal tissues for genes affiliated with Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for genes affiliated with Spinal Cord Infarction

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Pathways related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway37
9.3MTHFR, F2
2
Show member pathways
8.5F5, SERPINC1, F2
3
Show member pathways
8.5F2, SERPINC1, F5
4
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.5F5, SERPINC1, F2
5
Show member pathways
8.5F5, SERPINC1, F2

Compounds for genes affiliated with Spinal Cord Infarction

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Compounds related to Spinal Cord Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1certoparin449.6F2, SERPINC1
2polybrene449.5SERPINC1, F2
3hepaplastin449.5SERPINC1, F2
4fibrinopeptide a449.3F2, SERPINC1
5rivaroxaban44 1210.3SERPINC1, F2
6nafamostat mesilate449.2SERPINC1, F5
7batroxobin449.1F2, F5
8organon449.0F2, SERPINC1
9kaolin449.0APOH, F2, F5
10dextran sulfate449.0APOH, SERPINC1, F5
11coumarins449.0F5, F2, APOH
12vitamin b12449.0F5, APOH, MTHFR
13inogatran449.0F2, F5, SERPINC1
14ecarin449.0SERPINC1, F5, F2
15hirugen448.9F5, F2, SERPINC1
16spectrozyme448.9F2, F5, SERPINC1
17danaparoid448.9SERPINC1, F5, F2
18ancrod448.9F2, F5, SERPINC1
19monoethylglycinexylidide448.9F2, F5
20ximelagatran44 129.9F5, SERPINC1, F2
21heparinoids448.9F5, SERPINC1, F2
22fondaparinux448.9SERPINC1, F5, F2
23cardiolipin44 129.9F5, APOH, F2
24uric acid44 259.9F5, APOH, MTHFR
25bivalirudin44 129.9F2, SERPINC1, F5
26desogestrel44 129.9F5, SERPINC1, F2
27phosphatidylethanolamine44 129.9F5, F2, APOH
28argatroban44 129.9F2, SERPINC1, F5
29protamine sulfate448.9F5, SERPINC1, F2
30gestodene44 129.9F5, SERPINC1, F2
31ristocetin448.9F2, SERPINC1, F5
32levonorgestrel44 60 29 1211.9F2, SERPINC1, F5
33coumarin44 3 50 2511.9SERPINC1, F2, F5
34desmopressin44 60 29 1211.9F2, F5, SERPINC1
35p002448.9F5, APOH, MTHFR
36hirudin448.8F2, F5, SERPINC1
37pge1448.8F2, F5, APOH
38protamine448.8F5, SERPINC1, F2
39dermatan sulfate448.8SERPINC1, F5, F2
40aprotinin44 129.8F2, SERPINC1, F5
41polyethylene glycol448.7SERPINC1, F5, F2
42folate448.5F5, MTHFR, SERPINC1, APOH
43kininogen448.5F5, SERPINC1, APOH, F2
44warfarin44 50 25 1211.0MTHFR, F5, APOH, SERPINC1, F2
45homocysteine44 259.0F5, MTHFR, SERPINC1, APOH, F2
46aspirin44 50 29 2511.0F2, APOH, MTHFR, F5, SERPINC1
47fibrinogen448.0F5, MTHFR, APOH, SERPINC1, F2
48creatinine447.9F5, MTHFR, SERPINC1, APOH, F2
49heparin44 29 25 1210.9MTHFR, SERPINC1, APOH, F2, F5
50estrogen447.9F2, MTHFR, SERPINC1, APOH, F5

GO Terms for genes affiliated with Spinal Cord Infarction

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Cellular components related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.3SERPINC1, F2
2extracellular spaceGO:0056157.8F5, SERPINC1, APOH, F2

Biological processes related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.5APOH, F2
2positive regulation of blood coagulationGO:0301949.4APOH, F2
3blood coagulation, intrinsic pathwayGO:0075979.3F2, APOH
4blood circulationGO:0080158.8F5, MTHFR
5blood coagulationGO:0075968.5F5, SERPINC1, F2

Molecular functions related to Spinal Cord Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.2SERPINC1, APOH
2serine-type endopeptidase activityGO:0042529.0F5, F2

Products for genes affiliated with Spinal Cord Infarction

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Sources for Spinal Cord Infarction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet