MCID: SPN185
MIFTS: 34

Spinal Cord Infarction malady

Categories: Neuronal diseases

Aliases & Classifications for Spinal Cord Infarction

Aliases & Descriptions for Spinal Cord Infarction:

Name: Spinal Cord Infarction 51
Infarction of Spinal Cord 69

Classifications:



Summaries for Spinal Cord Infarction

NINDS : 51 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called  in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards based summary : Spinal Cord Infarction, also known as infarction of spinal cord, is related to ischemic optic neuropathy and myocardial infarction. An important gene associated with Spinal Cord Infarction is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and pineal, and related phenotype is homeostasis/metabolism.

Related Diseases for Spinal Cord Infarction

Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
id Related Disease Score Top Affiliating Genes
1 ischemic optic neuropathy 29.3 APOH F2 SERPINC1
2 myocardial infarction 28.8 F2 F5 MTHFR SERPINC1
3 fibrocartilaginous embolism 11.3
4 anterior spinal artery syndrome 10.9
5 cervicitis 10.3
6 scn8a-related epilepsy with encephalopathy 10.1 F2 MTHFR
7 porphyria 10.1 F2 MTHFR
8 miller-dieker lissencephaly syndrome 10.1 F2 SERPINC1
9 influenza 10.1 F2 SERPINC1
10 freiberg's disease 10.1 F2 SERPINC1
11 chorioretinal scar 10.1 F2 SERPINC1
12 landau-kleffner syndrome 10.1 APOH F2
13 mixed hepatoblastoma 10.1 F2 SERPINC1
14 peanut allergy 10.1 F2 SERPINC1
15 dmd-related dilated cardiomyopathy 10.1 F2 SERPINC1
16 prostatitis 10.1 APOH F2
17 midline cystocele 10.1 F2 SERPINC1
18 schwannoma of jugular foramen 10.1 F2 SERPINC1
19 cerebellar astrocytoma 10.1 F2 SERPINC1
20 periosteal chondrosarcoma 10.1 F2 SERPINC1
21 angelucci's syndrome 10.0 F2 SERPINC1
22 multiple familial trichoepithelioma 10.0 F5 MTHFR
23 essential thrombocythemia 10.0 F2 SERPINC1
24 absence of innominate vein 10.0 F5 MTHFR
25 ovarian papillary cystadenoma 10.0 F2 SERPINC1
26 aminoaciduria 10.0 F5 MTHFR
27 epstein-barr virus hepatitis 10.0 F2 SERPINC1
28 hereditary alpha tryptasemia syndrome 10.0 F2 SERPINC1
29 med13l syndrome 10.0 APOH F5
30 scapuloperoneal myopathy, x-linked dominant 10.0 F2 SERPINC1
31 achard thiers syndrome 10.0 APOH F5
32 autoimmune disease of central nervous system 10.0 APOH F2
33 stt3a-cdg and stt3b-cdg 10.0 F5 SERPINC1
34 paraplegia 10.0
35 congenital insensitivity to pain with severe intellectual disability 10.0 F2 F5
36 hennekam lymphangiectasia-lymphedema syndrome 2 10.0 F2 SERPINC1
37 gastrointestinal defects and immunodeficiency syndrome 10.0 F5 MTHFR
38 bladder hepatoid adenocarcinoma 10.0 APOH F5
39 meningitis 10.0
40 aneurysm 10.0
41 hemolytic-uremic syndrome 10.0 F2 SERPINC1
42 oxyphilic adenoma 10.0 F2 F5
43 mental retardation hypotonia skin hyperpigmentation 10.0 F5 SERPINC1
44 stroke, ischemic 9.9 F2 F5
45 fletcher factor deficiency 9.9 F2 F5
46 mixed epithelial tumor of ovary 9.9 F2 MTHFR SERPINC1
47 glutathionuria 9.9 APOH F2 MTHFR
48 ductal carcinoma in situ 9.9 F2 MTHFR SERPINC1
49 myotonic dystrophy 9.9 F2 F5
50 alpha-2-plasmin inhibitor deficiency 9.9 F2 MTHFR SERPINC1

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to Spinal Cord Infarction

Symptoms & Phenotypes for Spinal Cord Infarction

MGI Mouse Phenotypes related to Spinal Cord Infarction:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 APOH F2 F5 MTHFR SERPINC1

Drugs & Therapeutics for Spinal Cord Infarction

Drugs for Spinal Cord Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 Cholinergic Agents Phase 4
4 Neuromuscular Agents Phase 4
5 Neurotransmitter Agents Phase 4,Phase 3
6 Anesthetics Phase 4
7 Peripheral Nervous System Agents Phase 4
8 abobotulinumtoxinA Phase 4
9 incobotulinumtoxinA Phase 4
10 onabotulinumtoxinA Phase 4
11 Botulinum Toxins Phase 4
12 Botulinum Toxins, Type A Phase 4
13
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
14
Clopidogrel Approved, Nutraceutical Phase 3 120202-66-6, 113665-84-2 60606
15 Platelet Aggregation Inhibitors Phase 3
16 Purinergic P2 Receptor Antagonists Phase 3
17 Purinergic P2Y Receptor Antagonists Phase 3
18
Epinephrine Approved, Vet_approved 51-43-4 5816
19
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
20
Menthol Approved 2216-51-5 16666
21 Anesthetics, Local
22 Epinephryl borate
23 Racepinephrine

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4
2 Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial Recruiting NCT00991029 Phase 3
3 Role of Stem Cells in Improving Implantation Rates in ICSI Patients Unknown status NCT01649752 Phase 1
4 Safety and Feasibility Study of Umbilical Cord Blood Mononuclear Cells Transplant to Treat Ischemic Stroke Recruiting NCT01673932 Phase 1
5 A Spinal Functional Magnetic Resonance Imagine (fMRI) Study of Resting-State, Motor Task and Acupoint Stimulation Completed NCT00629655
6 ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444
7 Impact of Interscalene Nerve Block on Cerebral Perfusion During Surgery in the Beachchair Position Completed NCT01983618
8 Cortical Recording and Stimulating Array Brain-Machine Interface Recruiting NCT01894802
9 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Recruiting NCT00912041
10 MyndMove Therapy for Severe Hemiparesis of the Upper Limb Following Stroke Recruiting NCT02266836
11 A Clinical Trial to Evaluate the HeartWare® Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL) Active, not recruiting NCT01966458

Search NIH Clinical Center for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

Anatomical Context for Spinal Cord Infarction

MalaCards organs/tissues related to Spinal Cord Infarction:

39
Spinal Cord, Skin, Pineal, Lung, Liver, Kidney, Brain

Publications for Spinal Cord Infarction

Articles related to Spinal Cord Infarction:

(show top 50) (show all 230)
id Title Authors Year
1
Spinal Cord Infarction in Hemoglobin SC Disease as an Amusement Park Accident. ( 27485695 )
2016
2
Gunshot wound causing anterior spinal cord infarction due to injury to the artery of adamkiewicz. ( 26892374 )
2016
3
Skin vasomotor hemiparesis followed by overactivity: characteristic thermography findings in a patient with Horner syndrome due to spinal cord infarction. ( 26811085 )
2016
4
Spinal cord infarction as a rare complication of fat embolism syndrome following bilateral intramedullary nailing of femur fractures. ( 27624445 )
2016
5
Acute posterior multifocal placoid pigment epitheliopathy presenting with multiple brain and spinal cord infarctions. ( 26810511 )
2016
6
Spinal cord infarction after bronchial artery embolization. ( 27011655 )
2016
7
Time course of diffusion weighted image and apparent diffusion coefficient in acute spinal cord infarction: A case report and review of the literature. ( 27098903 )
2016
8
Spinal Cord Infarction in a Patient with Hereditary Spherocytosis: A Case Report and Discussion. ( 27051541 )
2016
9
Analysis of Spinal Cord Infarction Associated with Aortic Stent Graft Placement Using Nationwide Inpatient Sample (2002-2011). ( 26958147 )
2016
10
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
11
Spinal Cord Infarction in Clinical Neurology: A Review of Characteristics and Long-Term Prognosis in Comparison to Cerebral Infarction. ( 27487411 )
2016
12
Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 27082966 )
2016
13
Fibrocartilaginous embolism: a comprehensive review of an under-studied cause of spinal cord infarction and proposed diagnostic criteria. ( 26833287 )
2016
14
Magnetic resonance imaging and diffusion-weighted imaging findings in posterior spinal cord infarction: Case report. ( 27183891 )
2016
15
Vascular Diseases of the Spinal Cord: Infarction, Hemorrhage, and Venous Congestive Myelopathy. ( 27616317 )
2016
16
Spinal cord infarction as a complication of hemodialysis. ( 25459747 )
2015
17
Acute spinal cord infarction after EUS-guided celiac plexus neurolysis. ( 26551729 )
2015
18
Cervical spinal cord infarction associated with the use of oral contraceptives for the treatment of acne in a healthy young woman. ( 25511216 )
2015
19
Giant cell arteritis presenting as spinal cord infarction. ( 26038276 )
2015
20
Lifestyle changes of a family caring for a 25-year-old quadriplegic man after delayed spinal cord infarction. ( 26055609 )
2015
21
Unusual reason of spinal cord infarction: tuberculous meningitis. ( 26143304 )
2015
22
A case of spinal cord infarction caused by polycythemia vera. ( 25900285 )
2015
23
Paraplegia Due to Spinal Cord Infarction After Coronary Artery Bypass Graft Surgery. ( 26553407 )
2015
24
Three unique presentations of atraumatic spinal cord infarction in the pediatric emergency department. ( 24786993 )
2014
25
Posterior spinal cord infarction due to fibrocartilaginous embolization in a 16-year-old athlete. ( 24958591 )
2014
26
Spinal cord infarction as a complication of percutaneous coronary intervention. ( 25082382 )
2014
27
Back pain--an ominous harbinger of spinal cord infarction. ( 25668920 )
2014
28
Spinal cord infarction in carriers of methylenetetrahydrofolate reductase-polymorphism-like unique risk factor: report of two cases. ( 25376315 )
2014
29
Spinal cord infarction in giant cell arteritis associated with scalp necrosis. ( 25035098 )
2014
30
Spinal cord infarction: a rare cause of paraplegia. ( 24966260 )
2014
31
Surgical repair following trauma to vascular graft causing spinal cord infarction. ( 24739653 )
2014
32
Spinal cord infarction and patent foramen ovale: is there a link? ( 25076895 )
2014
33
Evaluation of a patient with spinal cord infarction after a hypotensive episode. ( 25116880 )
2014
34
Longitudinally extensive spinal cord infarction in CADASIL. ( 25322762 )
2014
35
Late-onset cauda equina contrast enhancement: a rare magnetic resonance imaging finding in subacute spinal cord infarction. ( 25117720 )
2014
36
Paraparesis due to spinal cord infarction associated with acute aortic dissection. ( 24828828 )
2014
37
Delayed presentation of cerebellar and spinal cord infarction as a complication of computed tomography-guided transthoracic lung biopsy: a case report. ( 25113016 )
2014
38
Diffusion weighted imaging with trace diffusion weighted imaging, the apparent diffusion coefficient and exponential images in the diagnosis of spinal cord infarction. ( 23628439 )
2013
39
Cervical Spinal Cord Infarction After Decompressive Surgery: A Closer Look. ( 23376384 )
2013
40
Spinal cord infarction following minor trauma in children: fibrocartilaginous embolism as a putative cause. ( 23414133 )
2013
41
Dural arteriovenous fistula at the craniocervical junction mimicking acute brainstem and spinal cord infarction. ( 23753962 )
2013
42
Spinal cord infarction with cervical angina. ( 23199591 )
2013
43
Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention. ( 24355157 )
2013
44
Survival following spinal cord infarction. ( 23528791 )
2013
45
Unilateral posterior cervical spinal cord infarction due to spontaneous vertebral artery dissection. ( 24090478 )
2013
46
Spectrum of clinicoradiological findings in spinal cord infarction: Report of three cases and review of the literature. ( 23956562 )
2013
47
Spontaneous spinal epidural hematoma and spinal cord infarction following orthotopic liver transplantation: Case report and review of the literature. ( 24340232 )
2013
48
Complications arising after thoracic aortic surgery: a case report on an unusual spinal cord infarction. Physiopathological and clinical considerations. ( 23369427 )
2013
49
Spinal cord infarction in diabetic pregnancy: a case report. ( 23855498 )
2013
50
Spinal cord infarction associated with use of phentermine. ( 23913302 )
2013

Variations for Spinal Cord Infarction

Expression for Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for Spinal Cord Infarction

GO Terms for Spinal Cord Infarction

Cellular components related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 APOH F2 F5 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 8.8 F2 F5 SERPINC1

Biological processes related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 F2 F5 SERPINC1
2 blood coagulation GO:0007596 9.5 F2 F5 SERPINC1
3 platelet activation GO:0030168 9.46 F2 F5
4 blood circulation GO:0008015 9.43 F5 MTHFR
5 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F2
6 positive regulation of blood coagulation GO:0030194 9.26 APOH F2
7 negative regulation of fibrinolysis GO:0051918 9.16 APOH F2
8 hemostasis GO:0007599 9.13 F2 F5 SERPINC1
9 regulation of blood coagulation GO:0030193 8.8 APOH F2 SERPINC1

Molecular functions related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Spinal Cord Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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