MCID: SPN185
MIFTS: 33

Spinal Cord Infarction

Categories: Neuronal diseases

Aliases & Classifications for Spinal Cord Infarction

MalaCards integrated aliases for Spinal Cord Infarction:

Name: Spinal Cord Infarction 50
Infarction of Spinal Cord 69

Classifications:



External Ids:

UMLS 69 C2314994

Summaries for Spinal Cord Infarction

NINDS : 50 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called atheromatosis, in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards based summary : Spinal Cord Infarction, also known as infarction of spinal cord, is related to anterior spinal artery syndrome and mesenteric vascular occlusion. An important gene associated with Spinal Cord Infarction is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include spinal cord, skin and pineal, and related phenotype is homeostasis/metabolism.

Related Diseases for Spinal Cord Infarction

Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 anterior spinal artery syndrome 31.6 F2 SERPINC1
2 mesenteric vascular occlusion 29.7 F2 MTHFR
3 afibrinogenemia, congenital 29.6 F2 SERPINC1
4 pulmonary edema 29.3 F2 SERPINC1
5 sickle cell anemia 29.3 F2 MTHFR
6 afibrinogenemia 29.3 F2 F5
7 heart disease 28.5 F2 MTHFR SERPINC1
8 vascular disease 28.4 APOH F5 MTHFR SERPINC1
9 myocardial infarction 28.2 F2 F5 MTHFR SERPINC1
10 thrombosis 28.2 APOH F2 F5 MTHFR SERPINC1
11 patent foramen ovale 27.9 APOH F2 F5 MTHFR SERPINC1
12 stroke, ischemic 27.9 APOH F2 F5 MTHFR SERPINC1
13 ischemic optic neuropathy 27.7 APOH F2 F5 MTHFR SERPINC1
14 thrombophilia due to thrombin defect 27.7 APOH F2 F5 MTHFR SERPINC1
15 antiphospholipid syndrome 27.7 APOH F2 F5 MTHFR SERPINC1
16 cervicitis 10.4
17 fibrocartilaginous embolism 10.2
18 paraplegia 10.1
19 ischemic neuropathy 10.1 F2 MTHFR
20 aneurysm 10.1
21 intestinal impaction 10.1 F2 SERPINC1
22 fournier gangrene 10.1 F2 SERPINC1
23 leech infestation 10.1 F2 SERPINC1
24 splenic infarction 10.1 APOH F2
25 alpha-2-plasmin inhibitor deficiency 10.0 F2 SERPINC1
26 meningitis 10.0
27 aortic aneurysm 10.0
28 giant hemangioma 10.0 F2 SERPINC1
29 blue toe syndrome 10.0 F2 SERPINC1
30 intracranial embolism 10.0 F2 SERPINC1
31 papilledema 10.0 APOH F2
32 subendocardial myocardial infarction 10.0 F2 SERPINC1
33 purpura fulminans 10.0 F2 SERPINC1
34 esophageal varix 10.0 F2 SERPINC1
35 korean hemorrhagic fever 10.0 F2 SERPINC1
36 inherited blood coagulation disease 10.0 F2 SERPINC1
37 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.0
38 hypersplenism 10.0 F2 SERPINC1
39 hemorrhagic fever 10.0 F2 SERPINC1
40 inferior vena cava interruption 10.0 F5 MTHFR
41 factor xi deficiency 10.0 F2 SERPINC1
42 amaurosis fugax 10.0 F5 MTHFR
43 infective endocarditis 9.9 APOH F2
44 arteriovenous fistula 9.9
45 cerebritis 9.9
46 may-thurner syndrome 9.9 APOH F5
47 hemophilia b 9.9 F2 SERPINC1
48 acanthamoeba keratitis 9.9 APOH F5
49 hepatitis a 9.9 F2 SERPINC1
50 sticky platelet syndrome 9.9 F5 SERPINC1

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to Spinal Cord Infarction

Symptoms & Phenotypes for Spinal Cord Infarction

MGI Mouse Phenotypes related to Spinal Cord Infarction:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 APOH F2 F5 MTHFR SERPINC1

Drugs & Therapeutics for Spinal Cord Infarction

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial to Evaluate the HeartWare® Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL) Unknown status NCT01966458

Search NIH Clinical Center for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

Anatomical Context for Spinal Cord Infarction

MalaCards organs/tissues related to Spinal Cord Infarction:

38
Spinal Cord, Skin, Pineal, Lung, Kidney, Heart, Brain

Publications for Spinal Cord Infarction

Articles related to Spinal Cord Infarction:

(show top 50) (show all 259)
# Title Authors Year
1
Cocaine-Related Acute Spinal Cord Infarction. ( 29393308 )
2018
2
Endovascular treatment with tirofiban during the acute stage of cervical spinal cord infarction due to vertebral artery dissection. ( 29323631 )
2018
3
Spinal Cord Infarction Presenting as a Hemicord Syndrome: Report of 2 Cases. ( 29422381 )
2018
4
Spinal Cord Infarction Mimicking Acute Transverse Myelitis. ( 29441246 )
2017
5
Acute spinal cord infarction after aortobifemoral bypass. ( 28879909 )
2017
6
Rare spinal cord infarction in a patient with acute type B aortic dissection. ( 28329371 )
2017
7
Watershed spinal cord infarction developing after a hypotensive episode secondary to massive rectus sheath hematoma. ( 28404376 )
2017
8
Letter: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28431007 )
2017
9
In Reply: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28362933 )
2017
10
Pure motor unilateral leg paresis caused by a spinal cord infarction. ( 28213840 )
2017
11
Childhood idiopathic spinal cord infarction: Description of 7 cases and review of the literature. ( 28578817 )
2017
12
Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage. ( 28236596 )
2017
13
Spinal cord infarct caused from suspected fibrocartilaginous embolism. ( 28546875 )
2017
14
Letter: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28379470 )
2017
15
Rates of Spinal Cord Infarction After Repair of Aortic Aneurysm or Dissection. ( 28655811 )
2017
16
Factors contributing to spinal cord infarction occurring in surgery performed in the prone position. ( 28364170 )
2017
17
Expert's comment concerning Grand Rounds case entitled "Acute complete paraplegia of a 8-year-old girl caused by spinal cord infarction following minor trauma complicated with longitudinal signal change of spinal cord" by K. Nagata et al. (Eur Spine J, 2017: doi:10.1007/s00586-017-4995-9). ( 28409289 )
2017
18
Delayed spinal cord infarction following anterior cervical surgical decompression. ( 28993348 )
2017
19
Spinal cord infarction mimicking ischemic heart disease. ( 28717781 )
2017
20
Delayed Hospital Presentation and Neuroimaging in Non-surgical Spinal Cord Infarction. ( 28446898 )
2017
21
Spinal cord infarction in a sick neonate from predominant haemorrhagic aetiology: a case report. ( 28690873 )
2017
22
Hypothermia with Extreme Bradycardia following Spinal Cord Infarction of Septic Origin. ( 29109881 )
2017
23
Acute complete paraplegia of 8-year-old girl caused by spinal cord infarction following minor trauma complicated with longitudinal signal change of spinal cord. ( 28281001 )
2017
24
In Reply: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28402553 )
2017
25
Spinal Cord Infarction in the Course of a Septic Shock: About One Case and Review of the Literature. ( 28316845 )
2017
26
Intensive Gait Treatment Using a Robot Suit Hybrid Assistive Limb in Acute Spinal Cord Infarction: Report of Two Cases. ( 28990874 )
2017
27
Letter: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28362973 )
2017
28
A Population-Based Study of the Incidence of Acute Spinal Cord Infarction. ( 28702119 )
2017
29
Spinal Cord Infarction in Hemoglobin SC Disease as an Amusement Park Accident. ( 27485695 )
2016
30
Spinal cord infarction as a rare complication of fat embolism syndrome following bilateral intramedullary nailing of femur fractures. ( 27624445 )
2016
31
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
32
Spinal Cord Infarction in a Patient with Hereditary Spherocytosis: A Case Report and Discussion. ( 27051541 )
2016
33
Acute posterior multifocal placoid pigment epitheliopathy presenting with multiple brain and spinal cord infarctions. ( 26810511 )
2016
34
Spinal Cord Infarction in Clinical Neurology: A Review of Characteristics and Long-Term Prognosis in Comparison to Cerebral Infarction. ( 27487411 )
2016
35
Analysis of Spinal Cord Infarction Associated with Aortic Stent Graft Placement Using Nationwide Inpatient Sample (2002-2011). ( 26958147 )
2016
36
Skin vasomotor hemiparesis followed by overactivity: characteristic thermography findings in a patient with Horner syndrome due to spinal cord infarction. ( 26811085 )
2016
37
Gunshot wound causing anterior spinal cord infarction due to injury to the artery of adamkiewicz. ( 26892374 )
2016
38
Time course of diffusion weighted image and apparent diffusion coefficient in acute spinal cord infarction: A case report and review of the literature. ( 27098903 )
2016
39
Magnetic resonance imaging and diffusion-weighted imaging findings in posterior spinal cord infarction: Case report. ( 27183891 )
2016
40
Vascular Diseases of the Spinal Cord: Infarction, Hemorrhage, and Venous Congestive Myelopathy. ( 27616317 )
2016
41
Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 27082966 )
2016
42
Fibrocartilaginous embolism: a comprehensive review of an under-studied cause of spinal cord infarction and proposed diagnostic criteria. ( 26833287 )
2016
43
Spinal cord infarction after bronchial artery embolization. ( 27011655 )
2016
44
Cervical spinal cord infarction associated with the use of oral contraceptives for the treatment of acne in a healthy young woman. ( 25511216 )
2015
45
A case of spinal cord infarction caused by polycythemia vera. ( 25900285 )
2015
46
Lifestyle changes of a family caring for a 25-year-old quadriplegic man after delayed spinal cord infarction. ( 26055609 )
2015
47
Giant cell arteritis presenting as spinal cord infarction. ( 26038276 )
2015
48
Paraplegia Due to Spinal Cord Infarction After Coronary Artery Bypass Graft Surgery. ( 26553407 )
2015
49
Acute spinal cord infarction after EUS-guided celiac plexus neurolysis. ( 26551729 )
2015
50
Spinal cord infarction as a complication of hemodialysis. ( 25459747 )
2015

Variations for Spinal Cord Infarction

Expression for Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for Spinal Cord Infarction

GO Terms for Spinal Cord Infarction

Cellular components related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 APOH F2 F5 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 8.8 F2 F5 SERPINC1

Biological processes related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 F2 F5 SERPINC1
2 blood coagulation GO:0007596 9.5 F2 F5 SERPINC1
3 platelet degranulation GO:0002576 9.46 APOH F5
4 blood circulation GO:0008015 9.43 F5 MTHFR
5 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F2
6 positive regulation of blood coagulation GO:0030194 9.26 APOH F2
7 negative regulation of fibrinolysis GO:0051918 9.16 APOH F2
8 hemostasis GO:0007599 9.13 F2 F5 SERPINC1
9 regulation of blood coagulation GO:0030193 8.8 APOH F2 SERPINC1

Molecular functions related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Spinal Cord Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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