MCID: SPN186
MIFTS: 52

Spinal Cord Injury malady

Neuronal diseases category

Summaries for Spinal Cord Injury

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Sources:
33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. a spinal cord injury disrupts the signals. spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. most injuries don't cut through your spinal cord. instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. spinal cord injuries can be complete or incomplete. with a complete spinal cord injury, the cord can't send signals below the level of the injury. as a result, you are paralyzed below the injury. with an incomplete injury, you have some movement and sensation below the injury. a spinal cord injury is a medical emergency. immediate treatment can reduce long-term effects. treatments may include medicines, braces or traction to stabilize the spine, and surgery. later treatment usually includes medicines and rehabilitation therapy. mobility aids and assistive devices may help you to get around and do some daily tasks. nih: national institute of neurological disorders and stroke

MalaCards: Spinal Cord Injury, also known as spinal cord injuries, is related to multiple sclerosis and neuropathy. An important gene associated with Spinal Cord Injury is MPZ (myelin protein zero), and among its related pathways are Spinal Cord Injury and NgR-p75(NTR)-Mediated Signaling. The compounds glutamate and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related mouse phenotypes are nervous system and behavior/neurological.

NINDS:43 A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis.

Wikipedia:63 A spinal cord injury (SCI) refers to any injury to the spinal cord that is caused by trauma instead of... more...

Aliases & Classifications for Spinal Cord Injury

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Sources:
43NINDS, 48Orphanet, 30LifeMap Discovery™, 33MedlinePlus, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
spinal cord injury:
Prevalence: 1-5/10000


Aliases & Descriptions:

spinal cord injury 43 48 30
spinal cord injuries 33


External Ids:

ICD10 via Orphanet26 T09.3
SNOMED-CT via Orphanet57 90584004

Related Diseases for Spinal Cord Injury

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spinal Cord Injury:



Diseases related to spinal cord injury

Clinical Features for Spinal Cord Injury

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Drugs & Therapeutics for Spinal Cord Injury

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Spinal Cord Injury

Drug clinical trials:

Search ClinicalTrials for Spinal Cord Injury

Search NIH Clinical Center for Spinal Cord Injury

Search CenterWatch for Spinal Cord Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Cord Injury cell therapies at LifeMap Discovery.

Genetic Tests for Spinal Cord Injury

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Anatomical Context for Spinal Cord Injury

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Spinal Cord Injury:

32
Spinal cord, Bone, Brain, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Spinal Cord Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
4 Peripheral Nervous SystemPeripheral Nerve DomainMyelinating Schwann Cells Potential therapeutic candidate
5 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
6 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
7 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
8 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
13 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
15 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Spinal Cord Injury or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Spinal Cord Injury:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.8AQP4, KLK8, CALCA, SOD1, PDYN, ARG1
2MP:000538611.5KLK8, CALCA, SOD1, PDYN, DMD, MPZ
3MP:000537611.4ARG1, PDYN, SOD1, CALCA, KLK8, DMD
4MP:000538411.2DMD, MPZ, CNTF, NGFR, GDNF, GFRA3
5MP:000537710.6CALCA, SOD1, DMD, NGFR, AQP4

Publications for Spinal Cord Injury

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Genetic Variations for Spinal Cord Injury

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Expression for genes affiliated with Spinal Cord Injury

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Injury

Search GEO for disease gene expression data for Spinal Cord Injury.

Pathways for genes affiliated with Spinal Cord Injury

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome
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Pathways related to Spinal Cord Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.1AQP4, KLK8, PDYN, ARG1, NGFR, GDNF
210.7RTN4R, NGFR, ARG1
3
Hide members
10.6RTN4R, NGFR

Compounds for genes affiliated with Spinal Cord Injury

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Spinal Cord Injury according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1glutamate4411.6AQP4, CALCA, SOD1, PDYN, ARG1, MPZ
2nitric oxide44 11 2413.5CALCA, SOD1, PDYN, ARG1, DMD, CNTF
3cysteine4411.4SOD1, PDYN, DMD, MPZ, NGFR, GDNF
4acetylcholine44 49 28 11 2415.4CALCA, PDYN, DMD, CNTF, NGFR, GDNF
5lipid4411.3SOD1, PDYN, DMD, MPZ, CNTF, NGFR
6cyclic amp44 2412.3CALCA, ARG1, CNTF, NGFR, GDNF, FXYD1
7arginine4411.3SOD1, PDYN, ARG1, DMD, MPZ, CNTF
8zinc44 2412.3SOD1, PDYN, DMD, NGFR, GDNF, RTN4R
9potassium44 11 2413.2PDYN, DMD, CNTF, GDNF, AQP4
10dopamine44 28 11 2414.2CALCA, PDYN, CNTF, NGFR, GDNF
11ganglioside4411.2GDNF, NGFR, CNTF, MPZ
12catecholamine4411.2PDYN, CNTF, NGFR, GDNF
13bromodeoxyuridine4411.2GDNF, CNTF, MPZ, DMD
14creatinine4411.2GDNF, MPZ, DMD, SOD1, CALCA
15adenylate4411.1CALCA, PDYN, DMD, CNTF, GDNF
16amphetamine44 1112.1PDYN, CNTF, GDNF
17gaba4411.0PDYN, CNTF, NGFR, GDNF
186-hydroxydopamine4411.0SOD1, PDYN, GDNF
19tellurium4411.0NGFR, MPZ
20capsaicin44 2812.0CALCA, PDYN, GDNF
21serine4411.0KLK6, KLK8, DMD, MPZ, CNTF, NGFR
22ethanol44 49 11 2413.9PDYN, NGFR, GDNF, RTN4IP1
23oligonucleotide4410.9AQP4, GDNF, NGFR, DMD, PDYN
24norepinephrine44 11 2412.9CALCA, PDYN, CNTF, GDNF
25levodopa44 1111.9GDNF, PDYN, SOD1
26aminoglycosides4410.8GDNF, DMD
27riluzole44 28 1112.8SOD1, GDNF
28histamine44 28 2412.8AQP4, NGFR, CNTF, CALCA
29steroid4410.6KLK6, KLK8, PDYN, MPZ, NGFR

GO Terms for genes affiliated with Spinal Cord Injury

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Sources:
16Gene Ontology
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Cellular components related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0CNTF, NENF, ARG1, SOD1, CALCA, KLK8

Biological processes related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nervous system developmentGO:00739910.9AQP4, GFRA3, GDNF, NINJ1
2negative regulation of neuron apoptotic processGO:04352410.7SOD1, CNTF, GDNF
3negative regulation of axonogenesisGO:05077110.6RTN4R, NGFR
4tissue regenerationGO:04224610.5NINJ1, KLK6
5muscle cell cellular homeostasisGO:04671610.3DMD, SOD1

Products for genes affiliated with Spinal Cord Injury

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spinal Cord Injury

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet