MCID: SPN186
MIFTS: 67

Spinal Cord Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spinal Cord Injury

MalaCards integrated aliases for Spinal Cord Injury:

Name: Spinal Cord Injury 37 72 50 55
Spinal Cord Injuries 40

Characteristics:

Orphanet epidemiological data:

55
spinal cord injury
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 55 ORPHA90058
UMLS via Orphanet 70 C0037929
ICD10 via Orphanet 33 T09.3

Summaries for Spinal Cord Injury

MedlinePlus : 40 Your spinal cord is a bundle of nerves that runs down the middle of your back. It carries signals back and forth between your body and your brain. A spinal cord injury disrupts the signals. Spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. Most injuries don't cut through your spinal cord. Instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. Spinal cord injuries can be complete or incomplete. With a complete spinal cord injury, the cord can't send signals below the level of the injury. As a result, you are paralyzed below the injury. With an incomplete injury, you have some movement and sensation below the injury. A spinal cord injury is a medical emergency. Immediate treatment can reduce long-term effects. Treatments may include medicines, braces or traction to stabilize the spine, and surgery. Later treatment usually includes medicines and rehabilitation therapy. Mobility aids and assistive devices may help you to get around and do some daily tasks. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Spinal Cord Injury, also known as spinal cord injuries, is related to spinal cord disease and prostatitis. An important gene associated with Spinal Cord Injury is RTN4IP1 (Reticulon 4 Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Pregabalin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are behavior/neurological and homeostasis/metabolism

NINDS : 50 A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis

Wikipedia : 72 A spinal cord injury (SCI) is damage to the spinal cord that causes changes in its function, either... more...

Related Diseases for Spinal Cord Injury

Diseases related to Spinal Cord Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
# Related Disease Score Top Affiliating Genes
1 spinal cord disease 32.4 AQP4 GDNF TNF
2 prostatitis 30.6 CXCL8 IL6 TNF
3 brain injury 30.5 BDNF CASP3 GFAP IL6
4 myelitis 30.2 AQP4 IL6 TNF
5 fasciitis 30.1 CXCL8 IL6 TNF
6 pyelonephritis 30.1 CXCL8 IL6 TNF
7 traumatic brain injury 30.1 AQP4 BDNF CASP3 GFAP IL6
8 osteomyelitis 29.8 CXCL8 IL6 TNF
9 colitis 29.7 CXCL8 IL6 NOS2 TNF
10 multiple sclerosis 29.5 AQP4 BDNF GFAP IL6 MMP9 NOS2
11 transverse myelitis 29.3 AQP4 CXCL8 IL6 MMP9 TNF
12 respiratory failure 11.5
13 central cord syndrome 11.4
14 spasticity 11.4
15 paraplegia 11.3
16 syringomyelia 11.3
17 spinal shock 11.3
18 tethered cord syndrome 11.2
19 tethered spinal cord syndrome 10.9
20 acute cystitis 10.9
21 central cervical cord syndrome 10.9
22 myoclonus 10.9
23 swallowing disorders 10.9
24 cervicitis 10.6
25 scorpion envenomation 10.5 IL6 TNF
26 neurogenic bladder 10.5
27 episodic pain syndrome, familial, 1 10.5
28 neuronitis 10.5
29 cerebral artery occlusion 10.4 BDNF GDNF TNF
30 neurogenic bowel 10.4
31 acute vascular insufficiency of intestine 10.4 GDNF IL6 TNF
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
33 eales disease 10.4 IL6 NOS2 TNF
34 periventricular leukomalacia 10.4 IL6 NOS2 TNF
35 leukomalacia 10.4 IL6 NOS2 TNF
36 critical limb ischemia 10.4 IL6 TNF
37 internal hemorrhoid 10.4 CASP3 MMP9 NOS2
38 recurrent corneal erosion 10.4 CXCL8 IL6
39 toxic encephalopathy 10.4 BDNF CASP3 GFAP
40 rosacea 10.3 IL6 MMP9 TNF
41 idiopathic neutropenia 10.3 CASP3 IL6 TNF
42 neuromyelitis optica 10.3 AQP4 GFAP IL6
43 detrusor sphincter dyssynergia 10.3
44 bagassosis 10.3 CXCL8 IL6
45 crohn's colitis 10.3 CXCL8 NOS2 TNF
46 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6 TNF
47 status epilepticus 10.3 BDNF CASP3 GFAP
48 meconium aspiration syndrome 10.3 CXCL8 IL6 TNF
49 louse-borne relapsing fever 10.3 CXCL8 IL6 TNF
50 pulpitis 10.3 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Spinal Cord Injury:



Diseases related to Spinal Cord Injury

Symptoms & Phenotypes for Spinal Cord Injury

MGI Mouse Phenotypes related to Spinal Cord Injury:

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.42 NOS1 NGFR NOS2 BDNF GDNF AQP4
2 homeostasis/metabolism MP:0005376 10.36 NOS1 NGFR NOS2 BDNF AQP4 CASP3
3 growth/size/body region MP:0005378 10.35 NOS2 MMP9 NOS1 NGFR BDNF GDNF
4 digestive/alimentary MP:0005381 10.33 NOS1 NGFR NOS2 BDNF GDNF AQP4
5 cardiovascular system MP:0005385 10.31 NOS2 MMP9 NOS1 NGFR GDNF AQP4
6 cellular MP:0005384 10.3 NGFR MMP9 NOS1 CASP3 BDNF TNF
7 mortality/aging MP:0010768 10.3 MMP9 NOS1 NGFR NOS2 ARG1 GDNF
8 nervous system MP:0003631 10.28 NOS1 NGFR NOS2 BDNF GDNF AQP4
9 hematopoietic system MP:0005397 10.26 NOS2 MMP9 NOS1 NGFR ARG1 AQP4
10 immune system MP:0005387 10.24 MMP9 NOS1 NGFR ARG1 AQP4 CASP3
11 muscle MP:0005369 10.09 MMP9 NOS1 NGFR NOS2 GDNF CASP3
12 integument MP:0010771 10.08 NGFR MMP9 CASP3 BDNF TNF NOS2
13 adipose tissue MP:0005375 10.06 NGFR NOS1 TNF NOS2 PDYN IL6
14 renal/urinary system MP:0005367 9.92 NOS2 MMP9 NOS1 NGFR AQP4 CASP3
15 no phenotypic analysis MP:0003012 9.91 NOS1 CASP3 BDNF AQP4 TNF PDYN
16 reproductive system MP:0005389 9.91 MMP9 NOS1 CASP3 BDNF TNF NOS2
17 respiratory system MP:0005388 9.85 NOS1 NGFR NOS2 BDNF AQP4 CASP3
18 vision/eye MP:0005391 9.36 NOS1 NGFR NOS2 BDNF AQP4 CASP3
19 taste/olfaction MP:0005394 9.26 NGFR CASP3 BDNF GRIN1

Drugs & Therapeutics for Spinal Cord Injury

Drugs for Spinal Cord Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 401)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
2
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
3
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
5
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
6
Baclofen Approved Phase 4,Phase 2 1134-47-0 2284
7
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
8
Amitriptyline Approved Phase 4 50-48-6 2160
9
Perphenazine Approved Phase 4 58-39-9 4748
10
Teriparatide Approved, Investigational Phase 4,Phase 2 52232-67-4 16133850
11 Piracetam Approved, Investigational Phase 4 7491-74-9
12
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
13
Zoledronic acid Approved Phase 4,Phase 3,Phase 2 118072-93-8 68740
14
Neostigmine Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 59-99-4 4456
15
Darifenacin Approved, Investigational Phase 4,Phase 2 133099-04-4 444031
16
Oxybutynin Approved, Investigational Phase 4,Phase 3,Phase 2 5633-20-5 4634
17
Trospium Approved Phase 4,Phase 1 10405-02-4, 47608-32-2 5596 5284631
18
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
19
Oxcarbazepine Approved Phase 4 28721-07-5 34312
20
Midodrine Approved Phase 4,Phase 3,Phase 2 42794-76-3, 133163-28-7 4195
21
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
22
Acetaminophen Approved Phase 4 103-90-2 1983
23
Tramadol Approved, Investigational Phase 4,Phase 3 27203-92-5 33741
24
Dextromethorphan Approved Phase 4,Phase 2 125-71-3 5362449 5360696
25
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
26
Cycloserine Approved Phase 4 68-41-7 6234 401
27
Denosumab Approved Phase 4,Phase 2 615258-40-7
28
Rivaroxaban Approved Phase 4 366789-02-8
29
Trazodone Approved, Investigational Phase 4,Phase 2 19794-93-5 5533
30
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
31
Vancomycin Approved Phase 4 1404-90-6 14969 441141
32 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
33
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
34
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
35
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
36 Etiracetam Investigational Phase 4 33996-58-6
37
Lactitol Investigational Phase 4 585-86-4 3871
38 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
39 Anti-Anxiety Agents Phase 4,Phase 3,Phase 1,Phase 2
40 Anticonvulsants Phase 4,Phase 3,Phase 2
41 calcium channel blockers Phase 4,Phase 3
42 Calcium, Dietary Phase 4,Phase 3,Phase 2
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
46 Tranquilizing Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
47 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3
48 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
49 Vardenafil Dihydrochloride Phase 4,Phase 3
50 Vasodilator Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 984)

# Name Status NCT ID Phase Drugs
1 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
2 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
3 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
4 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
5 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
6 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
7 Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males Completed NCT01067391 Phase 4 tadalafil;placebo
8 Assess Efficacy in Subjects With Traumatic Spinal Cord Injury Completed NCT00667966 Phase 4 Vardenafil (Levitra, BAY 38-9456), 10 mg;Placebo;Vardenafil (Levitra, BAY 38-9456), 20 mg
9 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
10 Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients Completed NCT01579500 Phase 4 Botulinum toxin type A;normal saline
11 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed NCT00320281 Phase 4 botulinum toxin A
12 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed NCT00826228 Phase 4 teriparatide
13 Pressure Ulcer Healing With Microcyn Completed NCT02001558 Phase 4 Microcyn
14 Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury Completed NCT00252954 Phase 4 Levetiracetam
15 Project to Improve Symptoms and Mood in People With Spinal Cord Injury Completed NCT00592384 Phase 4 venlafaxine XR;placebo
16 A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction Completed NCT00654082 Phase 4 sildenafil;placebo
17 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
18 Zoledronic Acid Administration in Acute Spinal Cord Injury Completed NCT02042872 Phase 4 Zoledronic acid
19 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed NCT00745095 Phase 4 Neostigmine
20 Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity Completed NCT00800462 Phase 4 Oxybutynin Cl;Trospium Cl;Darifenacin Hydrogen Bromide (HBr)
21 Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis Completed NCT00629642 Phase 4 Solifenacin Succinate;Solifenacin Succinate;Oxybutynin Hydrochloride;Placebo
22 A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition Completed NCT00224029 Phase 4 Oxybutynin transdermal system
23 Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels Completed NCT01896037 Phase 4
24 Symptom Based Treatment of Neuropathic Pain Completed NCT02180880 Phase 4 Pregabalin and Oxcarbazepine
25 Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections Completed NCT00318591 Phase 4
26 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584 Phase 4
27 Body Temperature in Persons With Tetraplegia When Exposed to Cold Completed NCT01822535 Phase 4 Midodrine hydrochloride
28 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed NCT00507546 Phase 4 Ramelteon;Placebo
29 Evaluation of the Nursing C-Spine (Phase IV) Completed NCT01353352 Phase 4
30 C7-T1 Epidural Steroid Injections Versus Targeted Injection for Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4 Triamcinolone 80mg
31 Myobloc Atrophy Study Completed NCT02052024 Phase 4 Botox;MYOBLOC
32 Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression Completed NCT00634426 Phase 4
33 A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Completed NCT00642837 Phase 4 Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen
34 Spinal Cord Injury - Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD Recruiting NCT02537899 Phase 4 NeuroAiD
35 Bowel Care and Cardiovascular Function After Spinal Cord Injury Recruiting NCT01567605 Phase 4 Lidocaine lubricant
36 Lower Limb Function After Spinal Cord Injury Recruiting NCT02635893 Phase 4 D-Cycloserine;Placebo
37 Enhancing STDP After Spinal Cord Injury Recruiting NCT02701777 Phase 4 Seromycin;Dextromethorphan;Seromycin Placebo;Dextromethorphan Placebo
38 The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury Recruiting NCT03029442 Phase 4 Denosumab (Prolia)
39 Prevention of Bladder Dysfunction in Acute Spinal Cord Injury Recruiting NCT01698138 Phase 4 Onabotulinumtoxin A;Placebo
40 Absorption of Rivaroxaban in Patients With Cervical Spinal Cord Injury Recruiting NCT02970773 Phase 4 Rivaroxaban Oral Tablet
41 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
42 Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction Recruiting NCT03169582 Phase 4 Avanafil;Sildenafil
43 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
44 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
45 Intrathecal Baclofen (ITB) Delivery Location and Its Effect on Spasticity Recruiting NCT02903823 Phase 4 Baclofen bolus injection
46 Once Weekly GLP-1 in Persons With Spinal Cord Injury Not yet recruiting NCT03292315 Phase 4 Exenatide 2 MG Injection [Bydureon]
47 Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury Terminated NCT02355938 Phase 4 Fidaxomicin 200 mg;Placebo;Vancomycin
48 Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured Terminated NCT00869427 Phase 4 vitamin C
49 Efficacy Study of Pudendal Neuromodulation for the Treatment of Neurogenic Overactive Bladder Terminated NCT01023269 Phase 4
50 Efficacy and Safety of Growth Hormone Treatment in Spinal Cord Injury Unknown status NCT01329757 Phase 3 GH;Placebo

Search NIH Clinical Center for Spinal Cord Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Cord Injury cell therapies at LifeMap Discovery.

Genetic Tests for Spinal Cord Injury

Anatomical Context for Spinal Cord Injury

MalaCards organs/tissues related to Spinal Cord Injury:

38
Spinal Cord, Bone, Brain, Testes, Bone Marrow, Colon, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Spinal Cord Injury:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Peripheral Nervous System Peripheral Nerve Domain Myelinating Schwann Cells Potential therapeutic candidate
5 Spinal Cord Spinal Cord White Matter Oligodendrocyte Precursor Cells Potential therapeutic candidate
6 Brain Forebrain White Matter Oligodendrocyte Precursor Cells Potential therapeutic candidate
7 Neural Tube dP4 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
8 Neural Tube Anterior Entopeduncular Area Oligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural Tube Medial Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural Tube dP5 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural Tube Caudal Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural Tube dP3 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural Tube Lateral Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural Tube Motor Neural Progenitor Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
15 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Spinal Cord Injury

Articles related to Spinal Cord Injury:

(show top 50) (show all 1308)
# Title Authors Year
1
Inhibition of mammalian target of rapamycin complex 1 signaling by n-3 polyunsaturated fatty acids promotes locomotor recovery after spinal cord injury. ( 29436695 )
2018
2
Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury. ( 29451222 )
2018
3
Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury. ( 29444239 )
2018
4
Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury. ( 29443103 )
2018
5
The PI3K/Akt/FOXO3a pathway regulates regeneration following spinal cord injury in adult rats through TNF-I+ and p27kip1 expression. ( 29436581 )
2018
6
Diffusion Tensor Imaging in Diagnosis of Post-Traumatic Syringomyelia in Spinal Cord Injury in Rats. ( 29311540 )
2018
7
Photobiomodulation improves motor response in patients with spinal cord injury submitted to electromyographic evaluation: randomized clinical trial. ( 29441450 )
2018
8
Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury? ( 29451216 )
2018
9
Cross-cultural adaptation and validation of the "Spinal Cord Injury-Falls Concern Scale" in the Italian population. ( 29449685 )
2018
10
Response to "The neurogenic bowel dysfunction score in patients with spinal cord injury: methodological issues in reliability and validity". ( 29348689 )
2018
11
Spinal cord injury with central cord syndrome from surfing. ( 29423316 )
2018
12
Effects of treadmill training combined with serotonergic interventions on spasticity after contusive spinal cord injury. ( 29336209 )
2018
13
A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond. ( 29449826 )
2018
14
Through Clinical Observation: The History of Priapism After Spinal Cord Injuries. ( 29054772 )
2018
15
Scalp Acupuncture For The Treatment Of Motor Function In Acute Spinal Cord Injury: A Case Report. ( 29436375 )
2018
16
Stigma and self-management: an Interpretative Phenomenological Analysis of the impact of chronic recurrent urinary tract infections after spinal cord injury. ( 29449969 )
2018
17
The experience of spasticity after spinal cord injury: perceived characteristics and impact on daily life. ( 29339776 )
2018
18
Initial Outcomes from a Multicenter Study Utilizing the Indego Powered Exoskeleton in Spinal Cord Injury. ( 29434463 )
2018
19
Spinal cord injury in endovascular thoracoabdominal aortic aneurysm repair: prevalence, risk factors and preventive strategies. ( 29424186 )
2018
20
The experience of seeking, gaining and maintaining employment after traumatic spinal cord injury and the vocational pathways involved. ( 29439378 )
2018
21
The neurogenic bowel dysfunction score in patients with spinal cord injury: methodological issues in reliability and validity. ( 29348690 )
2018
22
Impact of spasticity on transfers and activities of daily living in individuals with spinal cord injury. ( 29334339 )
2018
23
Bladder irrigation with Chlorhexidine reduces bacteriuria in persons with spinal cord injury. ( 29355293 )
2018
24
Predictive Value of Braden Risk Factors in Pressure Ulcers of Outpatients With Spinal Cord Injury. ( 29436796 )
2018
25
Arm Cycling Combined with Passive Leg Cycling Enhances VO<sub>2peak</sub>in Persons with Spinal Cord Injury Above the Sixth Thoracic Vertebra. ( 29434464 )
2018
26
Voluntary ambulation using voluntary upper limb muscle activity and Hybrid Assistive LimbAr (HALAr) in a patient with complete paraplegia due to chronic spinal cord injury: A case report. ( 29351051 )
2018
27
Neuroprotective mechanisms of rutin for spinal cord injury through anti-oxidation and anti-inflammation and inhibition of p38 mitogen activated protein kinase pathway. ( 29451217 )
2018
28
Decreased hyperpolarization-activated cyclic nucleotide-gated channels are involved in bladder dysfunction associated with spinal cord injury. ( 29436607 )
2018
29
Anxiety and Depression in Patients with Traumatic Spinal Cord Injury: A Nationwide Population-Based Cohort Study. ( 28081205 )
2017
30
Reliability, validity and sensitivity to change of neurogenic bowel dysfunction score in patients with spinal cord injury. ( 28695900 )
2017
31
Prognosis Disclosure in Spinal Cord Injury. ( 28086999 )
2017
32
Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. ( 28948164 )
2017
33
Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury. ( 28082119 )
2017
34
MicroRNA-489-3p inhibits neurite growth by regulating PI3K/AKT pathway in spinal cord injury. ( 29441872 )
2017
35
Electroacupuncture alleviates the inflammatory response via effects on M1 and M2 macrophages after spinal cord injury. ( 28077367 )
2017
36
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 28628542 )
2017
37
Elucidation of Gene Expression Patterns in the Brain after Spinal Cord Injury. ( 28933220 )
2017
38
Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength. ( 28929919 )
2017
39
A simple tool to measure spasticity in spinal cord injury subjects. ( 28814047 )
2017
40
Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. ( 28479302 )
2017
41
Computer-Assessed Preference-Based Quality of Life in Patients with Spinal Cord Injury. ( 28948166 )
2017
42
Exergaming boxing versus heavy bag boxing: are these equipotent for individuals with spinal cord injury? ( 28092144 )
2017
43
Lentivirus-mediated silencing of the CTGF gene suppresses the formation of glial scar tissue in a rat model of spinal cord injury. ( 28089819 )
2017
44
Effective management of spasticity and impacts on weight change and resting energy expenditure in a female with spinal cord injury: a case report. ( 28919982 )
2017
45
Effect of quantitative assessment-based nursing intervention on the bowel function and life quality of patients with neurogenic bowel dysfunction after spinal cord injury. ( 29193471 )
2017
46
Phase-Dependent deficits during Reach-to-Grasp after Human Spinal Cord Injury. ( 28931614 )
2017
47
Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury. ( 28931573 )
2017
48
Shoulder pain in the Swiss spinal cord injury community: prevalence and associated factors. ( 28084832 )
2017
49
Exploratory study to suggest the possibility of MMP-8 and MMP-9 serum levels as early markers for remission after traumatic spinal cord injury. ( 27377304 )
2017
50
Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury. ( 28951789 )
2017

Variations for Spinal Cord Injury

Expression for Spinal Cord Injury

Search GEO for disease gene expression data for Spinal Cord Injury.

Pathways for Spinal Cord Injury

Pathways related to Spinal Cord Injury according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 ARG1 CASP3 CXCL8 GDNF GRIN1 IL6
2
Show member pathways
13.48 BDNF CASP3 CXCL8 GDNF GRIN1 IL6
3
Show member pathways
13.32 CASP3 CXCL8 GDNF GRIN1 IL6 MMP9
4
Show member pathways
13.28 BDNF CASP3 CXCL8 IL6 NGFR PLA2G2A
5
Show member pathways
12.87 CASP3 IL6 MMP9 NGFR TNF
6
Show member pathways
12.84 CASP3 CXCL8 GDNF IL6 TNF
7 12.82 CASP3 CXCL8 IL6 MMP9 NOS2
8
Show member pathways
12.54 CASP3 CXCL8 IL6 MMP9 TNF
9
Show member pathways
12.48 CASP3 NOS1 PDYN TNF
10
Show member pathways
12.46 CASP3 CXCL8 NOS1 NOS2
11
Show member pathways
12.29 CASP3 CXCL8 IL6 MMP9 TNF
12
Show member pathways
12.25 CXCL8 IL6 NOS2 TNF
13 12.23 CXCL8 IL6 MMP9 NGFR
14 12.21 CASP3 IL6 NOS2 TNF
15
Show member pathways
12.15 CXCL8 IL6 NOS2 TNF
16 12.11 CASP3 IL6 MMP9 NOS2 TNF
17 12.09 BDNF CASP3 GRIN1 NGFR
18
Show member pathways
11.96 CASP3 GRIN1 NOS1 TNF
19 11.92 CASP3 IL6 MMP9 TNF
20 11.86 CASP3 CXCL8 IL6 TNF
21 11.84 CXCL8 IL6 TNF
22 11.82 CXCL8 IL6 NOS2
23 11.82 CXCL8 IL6 MMP9 NOS2 TNF
24
Show member pathways
11.79 BDNF NGFR TNF
25 11.77 BDNF GDNF GFAP
26
Show member pathways
11.75 CASP3 CXCL8 TNF
27 11.71 AQP4 BDNF CASP3 CXCL8 GRIN1 IL6
28 11.68 CASP3 MMP9 NOS2
29 11.67 IL6 NOS2 TNF
30
Show member pathways
11.67 BDNF CASP3 NGFR
31 11.65 CASP3 CXCL8 IL6 MMP9
32 11.63 AQP4 ARG1 BDNF CASP3 CXCL8 GDNF
33 11.62 CXCL8 IL6 MMP9 TNF
34 11.62 ARG1 CASP3 CXCL8 IL6 NOS2 TNF
35 11.61 CASP3 MMP9 PLA2G2A
36
Show member pathways
11.6 ARG1 NOS1 NOS2
37 11.6 CASP3 CXCL8 IL6 NOS2 TNF
38 11.52 CXCL8 IL6 TNF
39 11.52 ARG1 CXCL8 IL6 NOS2
40 11.51 CXCL8 IL6 TNF
41 11.5 IL6 MMP9 TNF
42 11.5 CASP3 CXCL8 IL6 TNF
43 11.49 KLK8 NOS2 TNF
44
Show member pathways
11.45 CXCL8 IL6 MMP9 NOS2 TNF
45 11.44 CASP3 CXCL8 IL6 NOS2
46 11.32 CXCL8 IL6 MMP9
47 11.29 CASP3 NGFR TNF
48 11.21 NOS1 NOS2 PLA2G2A
49
Show member pathways
11.17 ARG1 NOS1 NOS2
50 11.01 BDNF CXCL8 GFAP IL6 TNF

GO Terms for Spinal Cord Injury

Cellular components related to Spinal Cord Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.36 ARG1 BDNF CXCL8 GDNF IL6 KLK8

Biological processes related to Spinal Cord Injury according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 CASP3 GDNF IL6 MMP9 NGFR
2 regulation of receptor activity GO:0010469 9.8 BDNF CXCL8 GDNF IL6 PDYN TNF
3 defense response to Gram-positive bacterium GO:0050830 9.74 IL6 PLA2G2A TNF
4 response to lipopolysaccharide GO:0032496 9.73 ARG1 CASP3 NGFR NOS2
5 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.69 CASP3 NGFR TNF
6 apoptotic signaling pathway GO:0097190 9.67 CASP3 NGFR TNF
7 response to glucocorticoid GO:0051384 9.63 CASP3 IL6 TNF
8 positive regulation of apoptotic process GO:0043065 9.63 CASP3 GRIN1 IL6 MMP9 NGFR TNF
9 neurotrophin TRK receptor signaling pathway GO:0048011 9.58 CASP3 NGFR
10 nitric oxide biosynthetic process GO:0006809 9.56 NOS1 NOS2
11 response to wounding GO:0009611 9.56 ARG1 CASP3 GFAP KLK8
12 positive regulation of guanylate cyclase activity GO:0031284 9.54 NOS1 NOS2
13 negative regulation of activated T cell proliferation GO:0046007 9.52 ARG1 CASP3
14 negative regulation of lipid storage GO:0010888 9.48 IL6 TNF
15 positive regulation of receptor binding GO:1900122 9.4 BDNF MMP9
16 peptidyl-cysteine S-nitrosylation GO:0018119 9.37 NOS1 NOS2
17 cellular response to lipopolysaccharide GO:0071222 9.35 ARG1 CXCL8 IL6 NOS2 TNF
18 arginine catabolic process GO:0006527 8.8 ARG1 NOS1 NOS2

Molecular functions related to Spinal Cord Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.56 GRIN1 NGFR NOS1 NOS2
2 FMN binding GO:0010181 9.37 NOS1 NOS2
3 arginine binding GO:0034618 9.32 NOS1 NOS2
4 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS1 NOS2
5 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS2
6 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS2

Sources for Spinal Cord Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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