MCID: SPN186
MIFTS: 63

Spinal Cord Injury malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Injury

Aliases & Descriptions for Spinal Cord Injury:

Name: Spinal Cord Injury 38 51 56
Spinal Cord Injuries 41

Characteristics:

Orphanet epidemiological data:

56
spinal cord injury
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 56 ORPHA90058
ICD10 via Orphanet 34 T09.3

Summaries for Spinal Cord Injury

MedlinePlus : 41 your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. a spinal cord injury disrupts the signals. spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. most injuries don't cut through your spinal cord. instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. spinal cord injuries can be complete or incomplete. with a complete spinal cord injury, the cord can't send signals below the level of the injury. as a result, you are paralyzed below the injury. with an incomplete injury, you have some movement and sensation below the injury. a spinal cord injury is a medical emergency. immediate treatment can reduce long-term effects. treatments may include medicines, braces or traction to stabilize the spine, and surgery. later treatment usually includes medicines and rehabilitation therapy. mobility aids and assistive devices may help you to get around and do some daily tasks. nih: national institute of neurological disorders and stroke

MalaCards based summary : Spinal Cord Injury, also known as spinal cord injuries, is related to detrusor sphincter dyssynergia and neuropathy. An important gene associated with Spinal Cord Injury is RTN4IP1 (Reticulon 4 Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Pregabalin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and behavior/neurological

NINDS : 51 A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis

Wikipedia : 71 The spine consists of the spinal cord, which is a group of nerves that are protected by the individual... more...

Related Diseases for Spinal Cord Injury

Diseases related to Spinal Cord Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
id Related Disease Score Top Affiliating Genes
1 detrusor sphincter dyssynergia 30.3 CXCL8 IL6 NOS2 TGFB1 TNF
2 neuropathy 29.9 CXCL8 IL6 TNF
3 pyelonephritis 29.8 CXCL8 NOS2 TNF
4 histiocytoma 29.6 CXCL8 MMP9 TNF
5 burns 29.2 CXCL8 IL6 MMP9 TGFB1 TNF
6 central cord syndrome 11.3
7 spasticity 11.3
8 paraplegia 11.2
9 spinal shock 11.2
10 syringomyelia 11.2
11 respiratory failure 11.2
12 spinal cord disease 11.2
13 tethered cord syndrome 11.1
14 swallowing disorders 10.8
15 central cervical cord syndrome 10.8
16 acute cystitis 10.8
17 fibrocartilaginous embolism 10.8
18 tethered spinal cord syndrome 10.8
19 myoclonus 10.8
20 cervicitis 10.5
21 neurogenic bladder 10.4
22 neuronitis 10.4
23 bronchopulmonary dysplasia 10.3 GFAP MMP9
24 neurogenic bowel 10.3
25 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
26 measles 10.3 GDNF IL6 TNF
27 vogt-koyanagi-harada disease 10.3 CASP3 IL6 TNF
28 ectodermal dysplasia bartalos type 10.3 IL6 NOS2 TNF
29 psychosexual disorder 10.2 BDNF GDNF NOS1
30 leydig cell hypoplasia 10.2 IL6 NOS2 TNF
31 gastroduodenal crohn's disease 10.2 GDNF NOS1 TNF
32 leukoplakia of vagina 10.2 IL6 MMP9 TNF
33 hypersensitivity reaction type iii disease 10.2 CXCL8 MMP9
34 senile atrophy of choroid 10.2 CASP3 MMP9 NOS2
35 niemann-pick disease 10.2 AQP4 GFAP IL6
36 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6 TNF
37 uterine adnexa cancer 10.2 IL6 MMP9 TNF
38 esophagus lymphoma 10.2 CXCL8 IL6 TNF
39 amyotrophic lateral sclerosis type 14 10.2 CXCL8 NOS2 TNF
40 cicatricial lagophthalmos 10.2 CXCL8 IL6 TNF
41 autosomal recessive type iv ehlers-danlos syndrome 10.2 CXCL8 IL6 TNF
42 orthostatic proteinuria 10.2 CXCL8 IL6 TNF
43 erb-duchenne and dejerine-klumpke palsies 10.2 CXCL8 IL6 TNF
44 congenital hypoplastic anemia 10.2 IL6 NOS1 TNF
45 inappropriate adh syndrome 10.2 CXCL8 IL6 TNF
46 atrophy of prostate 10.2 CXCL8 IL6 TNF
47 hypertelorism, preauricular sinus, punctal pits, and deafness 10.2 CASP3 NOS2 PLA2G2A
48 ovarian mucinous adenocarcinoma 10.2 BDNF CASP3 GFAP TNF
49 larynx carcinoma in situ 10.2 CASP3 CXCL8 IL6
50 adnp syndrome 10.2 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Spinal Cord Injury:



Diseases related to Spinal Cord Injury

Symptoms & Phenotypes for Spinal Cord Injury

GenomeRNAi Phenotypes related to Spinal Cord Injury according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 NOS2 TGFB1 TNF CASP3 CXCL8 GDNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 TGFB1 TNF CASP3 CXCL8 GDNF NGFR

MGI Mouse Phenotypes related to Spinal Cord Injury:

44 (show all 21)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.44 AQP4 BDNF CASP3 GDNF GFAP GRIN1
2 cellular MP:0005384 10.39 NOS1 NOS2 RTN4R TGFB1 TNF BDNF
3 homeostasis/metabolism MP:0005376 10.37 AQP4 ARG1 BDNF CASP3 GFAP GRIN1
4 cardiovascular system MP:0005385 10.36 AQP4 CASP3 GDNF GFAP GRIN1 IL6
5 growth/size/body region MP:0005378 10.36 GFAP GRIN1 IL6 MMP9 NGFR NOS1
6 digestive/alimentary MP:0005381 10.35 NOS2 TGFB1 TNF AQP4 BDNF CASP3
7 hematopoietic system MP:0005397 10.31 CASP3 GDNF GRIN1 IL6 MMP9 NGFR
8 mortality/aging MP:0010768 10.3 AQP4 ARG1 BDNF CASP3 GDNF GFAP
9 immune system MP:0005387 10.29 NGFR NOS1 NOS2 TGFB1 TNF AQP4
10 nervous system MP:0003631 10.28 AQP4 ARG1 BDNF CASP3 GDNF GFAP
11 endocrine/exocrine gland MP:0005379 10.21 AQP4 BDNF CASP3 GDNF IL6 NOS1
12 muscle MP:0005369 10.13 GFAP IL6 MMP9 NGFR NOS1 NOS2
13 integument MP:0010771 10.1 NOS2 TGFB1 TNF BDNF CASP3 IL6
14 adipose tissue MP:0005375 10.08 IL6 NGFR NOS1 NOS2 TGFB1 TNF
15 liver/biliary system MP:0005370 10.02 ARG1 IL6 NGFR NOS1 NOS2 TGFB1
16 renal/urinary system MP:0005367 9.97 AQP4 CASP3 GDNF IL6 MMP9 NGFR
17 reproductive system MP:0005389 9.96 NOS2 TGFB1 TNF BDNF CASP3 GDNF
18 no phenotypic analysis MP:0003012 9.91 AQP4 BDNF CASP3 GRIN1 NOS1 RTN4R
19 respiratory system MP:0005388 9.9 AQP4 BDNF CASP3 GRIN1 IL6 MMP9
20 vision/eye MP:0005391 9.4 TNF AQP4 BDNF CASP3 GFAP GRIN1
21 taste/olfaction MP:0005394 9.26 BDNF CASP3 GRIN1 NGFR

Drugs & Therapeutics for Spinal Cord Injury

Drugs for Spinal Cord Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 414)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
2
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
3
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
5
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 124-94-7 31307
6
Amitriptyline Approved Phase 4 50-48-6 2160
7
Perphenazine Approved Phase 4 58-39-9 4748
8
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
9 Piracetam Approved Phase 4 7491-74-9
10
Teriparatide Approved, Investigational Phase 4,Phase 2 52232-67-4 16133850
11
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
12
Zoledronic acid Approved Phase 4,Phase 3,Phase 2 118072-93-8 68740
13
Neostigmine Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 59-99-4 4456
14
Darifenacin Approved, Investigational Phase 4,Phase 2 133099-04-4 444031
15
Oxybutynin Approved, Investigational Phase 4,Phase 3 5633-20-5 4634
16
Trospium Approved Phase 4,Phase 1 10405-02-4, 47608-32-2 5596 5284631
17
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
18
Oxcarbazepine Approved Phase 4 28721-07-5 34312
19
Midodrine Approved Phase 4,Phase 3,Phase 2 133163-28-7, 42794-76-3 4195
20
Acetaminophen Approved Phase 4 103-90-2 1983
21
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
22
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
23
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
24
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
25
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
26
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
27
Baclofen Approved Phase 4,Phase 3,Phase 2 1134-47-0 2284
28
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
29
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
30
Dextromethorphan Approved Phase 4,Phase 2 125-71-3 5360696 5362449
31
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516
32
Cycloserine Approved Phase 4 68-41-7 401 6234
33
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
34
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
35
Denosumab Approved Phase 4,Phase 2 615258-40-7
36
Deferiprone Approved Phase 4 30652-11-0 2972
37
Vancomycin Approved Phase 4 1404-90-6 441141 14969
38 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
39
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
40
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
41 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
42 Anti-Anxiety Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Anticonvulsants Phase 4,Phase 3,Phase 2
44 calcium channel blockers Phase 4,Phase 3,Phase 1
45 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
46 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
49 Tranquilizing Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
50 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 980)
id Name Status NCT ID Phase
1 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
2 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4
3 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
4 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4
5 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
6 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4
7 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
8 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
9 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4
10 Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males Completed NCT01067391 Phase 4
11 Assess Efficacy in Subjects With Traumatic Spinal Cord Injury Completed NCT00667966 Phase 4
12 Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients Completed NCT01579500 Phase 4
13 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed NCT00320281 Phase 4
14 Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury Completed NCT00252954 Phase 4
15 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed NCT00826228 Phase 4
16 Project to Improve Symptoms and Mood in People With Spinal Cord Injury Completed NCT00592384 Phase 4
17 A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction Completed NCT00654082 Phase 4
18 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
19 Zoledronic Acid Administration in Acute Spinal Cord Injury Completed NCT02042872 Phase 4
20 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed NCT00745095 Phase 4
21 Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity Completed NCT00800462 Phase 4
22 Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis Completed NCT00629642 Phase 4
23 A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition Completed NCT00224029 Phase 4
24 Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels Completed NCT01896037 Phase 4
25 Symptom Based Treatment of Neuropathic Pain Completed NCT02180880 Phase 4
26 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584 Phase 4
27 Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections Completed NCT00318591 Phase 4
28 Body Temperature in Persons With Tetraplegia When Exposed to Cold Completed NCT01822535 Phase 4
29 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed NCT00507546 Phase 4
30 Evaluation of the Nursing C-Spine (Phase IV) Completed NCT01353352 Phase 4
31 C7-T1 Epidural Steroid Injections Versus Targeted Injection for Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4
32 Myobloc Atrophy Study Completed NCT02052024 Phase 4
33 Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression Completed NCT00634426 Phase 4
34 A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Completed NCT00642837 Phase 4
35 Comparison of Bilateral Thoracic Paravertebral Block to Thoracic Epidural Analgesia for Post Operative Analgesia in Patients Undergoing Abdominal Surgery Completed NCT01735851 Phase 4
36 Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier Completed NCT00878371 Phase 4
37 Spinal Cord Injury - Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD Recruiting NCT02537899 Phase 4
38 Bowel Care and Cardiovascular Function After Spinal Cord Injury Recruiting NCT01567605 Phase 4
39 Lower Limb Function After Spinal Cord Injury Recruiting NCT02635893 Phase 4
40 Prevention of Bladder Dysfunction in Acute Spinal Cord Injury Recruiting NCT01698138 Phase 4
41 Pressure Ulcer Healing With Microcyn Recruiting NCT02001558 Phase 4
42 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4
43 Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction Recruiting NCT03169582 Phase 4
44 Effect of Heat Exposure on Cognition in Persons With Tetraplegia Recruiting NCT02488824 Phase 4
45 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Recruiting NCT02379156 Phase 4
46 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
47 Intrathecal Baclofen (ITB) Delivery Location and Its Effect on Spasticity Recruiting NCT02903823 Phase 4
48 Treatment for Alcohol Dependence With Gabapentin Recruiting NCT02771925 Phase 4
49 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Recruiting NCT03181464 Phase 4
50 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4

Search NIH Clinical Center for Spinal Cord Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Cord Injury cell therapies at LifeMap Discovery.

Genetic Tests for Spinal Cord Injury

Anatomical Context for Spinal Cord Injury

MalaCards organs/tissues related to Spinal Cord Injury:

39
Spinal Cord, Bone, Brain, Bone Marrow, Prostate, Testes, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Spinal Cord Injury:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Peripheral Nervous System Peripheral Nerve Domain Myelinating Schwann Cells Potential therapeutic candidate
5 Spinal Cord Spinal Cord White Matter Oligodendrocyte Precursor Cells Potential therapeutic candidate
6 Brain Forebrain White Matter Oligodendrocyte Precursor Cells Potential therapeutic candidate
7 Neural Tube dP4 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
8 Neural Tube Anterior Entopeduncular Area Oligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural Tube Medial Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural Tube dP5 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural Tube Caudal Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural Tube dP3 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural Tube Lateral Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural Tube Motor Neural Progenitor Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
15 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Spinal Cord Injury

Articles related to Spinal Cord Injury:

(show top 50) (show all 1232)
id Title Authors Year
1
Modeling Perceived Exertion during Graded Arm Cycling Exercise in Spinal Cord Injury. ( 28079704 )
2017
2
Bacterial load of conditioned pressure ulcers is not a predictor for early flap failure in spinal cord injury. ( 28071687 )
2017
3
RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model. ( 28088077 )
2017
4
Determinants of quality of life among community-dwelling persons with spinal cord injury: A path analysis. ( 28091431 )
2017
5
Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model. ( 28125047 )
2017
6
Electroacupuncture alleviates the inflammatory response via effects on M1 and M2 macrophages after spinal cord injury. ( 28077367 )
2017
7
Lentivirus-mediated silencing of the CTGF gene suppresses the formation of glial scar tissue in a rat model of spinal cord injury. ( 28089819 )
2017
8
Anxiety and Depression in Patients with Traumatic Spinal Cord Injury: A Nationwide Population-Based Cohort Study. ( 28081205 )
2017
9
Resistance of interleukin-6 to the extracellular inhibitory environment promotes axonal regeneration and functional recovery following spinal cord injury. ( 28075461 )
2017
10
Perspectives of individuals with sub-acute spinal cord injury after personalized adapted locomotor training. ( 28084843 )
2017
11
Correlating spinal cord injuries with neurogenic bladder pathophysiology. ( 28090756 )
2017
12
What do spinal cord injury patients think of their improvement? A distribution and anchor based study of the minimal clinically important difference of the Spinal Cord Independence Measure III (SCIM III). ( 28084060 )
2017
13
Activation of KCNQ channels suppresses spontaneous activity in DRG neurons and reduces chronic pain after spinal cord injury. ( 28073317 )
2017
14
Exergaming boxing versus heavy bag boxing: are these equipotent for individuals with spinal cord injury? ( 28092144 )
2017
15
Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury. ( 28082119 )
2017
16
Femoral and Lumbar Fractures During Rehabilitation for a Traumatic Spinal Cord Injury in Osteogenesis Imperfecta: A Case Presentation. ( 28483687 )
2017
17
Identification of temporal genes involved in the mechanisms of spinal cord injury. ( 28071686 )
2017
18
Exploratory study to suggest the possibility of MMP-8 and MMP-9 serum levels as early markers for remission after traumatic spinal cord injury. ( 27377304 )
2017
19
Ginsenoside Rg3 Improves Recovery from Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation. ( 28085110 )
2017
20
Shoulder pain in the Swiss spinal cord injury community: prevalence and associated factors. ( 28084832 )
2017
21
Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. ( 28479302 )
2017
22
Prognosis Disclosure in Spinal Cord Injury. ( 28086999 )
2017
23
Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury. ( 28089079 )
2017
24
Effect of Concomitant Pain Medications on Response to Pregabalin in Patients with Postherpetic Neuralgia or Spinal Cord Injury-Related Neuropathic Pain. ( 28072797 )
2017
25
Poster 342 Tethered Cord Syndrome in a Patient with 40-Year History of Spinal Cord Injury: A Case Report. ( 27673095 )
2016
26
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 27820732 )
2016
27
Neurogenic Megacolon in Spinal Cord Injury. ( 27959751 )
2016
28
Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery. ( 27651756 )
2016
29
The correlation between dietary fat intake and blood pressure among people with spinal cord injury. ( 27648172 )
2016
30
Epidemiology of spinal cord injury without radiographic abnormality in children: a nationwide perspective. ( 27209042 )
2016
31
Dopaminergic treatment of restless legs syndrome in spinal cord injury patients with neuropathic pain. ( 28053765 )
2016
32
Severe spasticity in lower extremities is associated with reduced adiposity and lower fasting plasma glucose level in persons with spinal cord injury. ( 27618974 )
2016
33
Time-Dependent Discrepancies between Assessments of Sensory Function after Incomplete Cervical Spinal Cord Injury. ( 27203696 )
2016
34
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. ( 27256824 )
2016
35
PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After Spinal Cord Injury. ( 27209304 )
2016
36
Meliorating microcirculatory with melatonin in rat model of spinal cord injury using laser Doppler flowmetry. ( 27648716 )
2016
37
Discovertebral (Andersson) lesion of the Ankylosing Spondylitis, a cause of autonomic dysreflexia in spinal cord injury. ( 28053752 )
2016
38
THE EFFECT OF MONOSIALOGANGLYOSIDE (GM-1) ADMINISTRATION IN SPINAL CORD INJURY. ( 27217811 )
2016
39
Brain Machine Interface- facilitated Neurorehabilitation via Spinal Stimulation after Spinal Cord Injury: Recent Progress and Future Perspectives. ( 27216571 )
2016
40
Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats. ( 27995942 )
2016
41
Disruption of locomotion in response to hindlimb muscle stretch at acute and chronic time points after a spinal cord injury in rats. ( 27196003 )
2016
42
Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats. ( 28039004 )
2016
43
Electroacupuncture at Zusanli (ST36) ameliorates colonic neuronal nitric oxide synthase upregulation in rats with neurogenic bowel dysfunction following spinal cord injury. ( 27377302 )
2016
44
Effects of botulinum toxin A injections in spinal cord injury patients with detrusor overactivity and detrusor sphincter dyssynergia. ( 27563834 )
2016
45
An Increased Serum Level of Lipoprotein(a) Is a Predictor for Deep Vein Thrombosis in Patients with Spinal Cord Injuries. ( 26546997 )
2016
46
Identifying and classifying quality of life tools for neurogenic bladder function after spinal cord injury: A systematic review. ( 27734771 )
2016
47
Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats. ( 27641997 )
2016
48
Treating spinal cord injury via sustained drug delivery from calcium phosphate coatings. ( 27651766 )
2016
49
Kinematic gait parameters are highly sensitive measures of motor deficits and spinal cord injury in mice subjected to experimental autoimmune encephalomyelitis. ( 27639322 )
2016
50
Long-Term Outcomes and Longitudinal Changes of Neurogenic Bowel Management in Adults With Pediatric-Onset Spinal Cord Injury. ( 27473299 )
2016

Variations for Spinal Cord Injury

Expression for Spinal Cord Injury

Search GEO for disease gene expression data for Spinal Cord Injury.

Pathways for Spinal Cord Injury

Pathways related to Spinal Cord Injury according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 ARG1 CASP3 CXCL8 GDNF GRIN1 IL6
2
Show member pathways
13.55 BDNF CASP3 CXCL8 GDNF GRIN1 IL6
3
Show member pathways
13.49 BDNF CASP3 CXCL8 GRIN1 IL6 NOS1
4
Show member pathways
13.42 BDNF CASP3 CXCL8 IL6 NGFR TGFB1
5
Show member pathways
13.32 CASP3 CXCL8 GDNF GRIN1 IL6 MMP9
6
Show member pathways
13.29 BDNF CASP3 CXCL8 IL6 NGFR PLA2G2A
7
Show member pathways
12.9 CASP3 CXCL8 IL6 MMP9 NOS2 TGFB1
8
Show member pathways
12.89 CASP3 IL6 MMP9 NGFR TNF
9
Show member pathways
12.86 CASP3 CXCL8 GDNF IL6 TGFB1 TNF
10
Show member pathways
12.72 BDNF IL6 NGFR TGFB1 TNF
11 12.68 CASP3 CXCL8 IL6 MMP9 NOS2 TGFB1
12
Show member pathways
12.48 CASP3 CXCL8 NOS1 NOS2
13
Show member pathways
12.35 CASP3 CXCL8 IL6 MMP9 TNF
14 12.31 CASP3 MMP9 TGFB1 TNF
15
Show member pathways
12.28 CXCL8 IL6 NOS2 TNF
16
Show member pathways
12.27 CASP3 NOS2 TGFB1 TNF
17 12.25 CXCL8 IL6 MMP9 NGFR
18 12.24 CASP3 IL6 NOS2 TGFB1 TNF
19
Show member pathways
12.2 CXCL8 IL6 NOS2 TNF
20 12.15 CASP3 IL6 MMP9 NOS2 TGFB1 TNF
21 12.13 BDNF CASP3 GRIN1 NGFR
22
Show member pathways
12 CASP3 GRIN1 NOS1 TNF
23 11.97 CASP3 IL6 MMP9 TNF
24 11.91 AQP4 BDNF CASP3 CXCL8 GRIN1 IL6
25 11.89 IL6 NGFR TGFB1
26 11.89 CASP3 CXCL8 IL6 TGFB1 TNF
27 11.88 CXCL8 IL6 TGFB1 TNF
28 11.87 CASP3 CXCL8 TGFB1
29
Show member pathways
11.87 CXCL8 IL6 TGFB1
30 11.83 CXCL8 IL6 NOS2
31
Show member pathways
11.83 BDNF NGFR TNF
32 11.8 BDNF GDNF GFAP
33 11.79 CXCL8 IL6 MMP9 NOS2 TGFB1 TNF
34
Show member pathways
11.77 CASP3 CXCL8 TNF
35 11.77 IL6 TGFB1 TNF
36 11.76 CASP3 CXCL8 IL6 NOS2 TNF
37 11.74 IL6 NOS2 TGFB1 TNF
38 11.7 CASP3 MMP9 NOS2
39
Show member pathways
11.7 BDNF CASP3 NGFR RTN4R
40 11.68 CASP3 CXCL8 IL6 MMP9
41 11.64 CASP3 MMP9 PLA2G2A
42
Show member pathways
11.63 ARG1 NOS1 NOS2
43 11.63 AQP4 ARG1 BDNF CASP3 CXCL8 GDNF
44 11.6 CXCL8 IL6 MMP9 TGFB1 TNF
45 11.58 ARG1 CXCL8 IL6 NOS2
46 11.57 CASP3 CXCL8 IL6 TNF
47
Show member pathways
11.57 CXCL8 IL6 MMP9 NOS2 TNF
48 11.55 CXCL8 IL6 TNF
49 11.54 IL6 MMP9 TNF
50 11.51 ARG1 NGFR RTN4R

GO Terms for Spinal Cord Injury

Cellular components related to Spinal Cord Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 GRIN1 NGFR RTN4R TGFB1 TNF
2 extracellular region GO:0005576 9.32 ARG1 BDNF CXCL8 GDNF IL6 MMP9
3 membrane raft GO:0045121 9.26 CASP3 NOS1 RTN4R TNF

Biological processes related to Spinal Cord Injury according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.94 GDNF GRIN1 TGFB1 TNF
2 inflammatory response GO:0006954 9.91 CXCL8 IL6 NGFR TGFB1 TNF
3 regulation of cell proliferation GO:0042127 9.9 IL6 NOS2 TGFB1 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 IL6 PLA2G2A TGFB1 TNF
5 response to organic substance GO:0010033 9.83 CASP3 TGFB1 TNF
6 wound healing GO:0042060 9.82 CASP3 IL6 TGFB1
7 positive regulation of protein kinase B signaling GO:0051897 9.81 IL6 TGFB1 TNF
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 CASP3 NGFR TNF
9 response to hypoxia GO:0001666 9.8 CASP3 NOS1 NOS2 TGFB1
10 cell redox homeostasis GO:0045454 9.79 IL6 NOS1 NOS2
11 cellular response to organic cyclic compound GO:0071407 9.78 CASP3 TGFB1 TNF
12 apoptotic signaling pathway GO:0097190 9.77 CASP3 NGFR TNF
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.76 IL6 TGFB1 TNF
14 response to glucocorticoid GO:0051384 9.75 CASP3 IL6 TNF
15 defense response to Gram-positive bacterium GO:0050830 9.73 IL6 PLA2G2A TNF
16 response to lipopolysaccharide GO:0032496 9.65 ARG1 CASP3 IL6 NGFR NOS2
17 nitric oxide biosynthetic process GO:0006809 9.64 NOS1 NOS2
18 negative regulation of fat cell differentiation GO:0045599 9.63 IL6 TGFB1 TNF
19 positive regulation of guanylate cyclase activity GO:0031284 9.62 NOS1 NOS2
20 response to wounding GO:0009611 9.62 ARG1 CASP3 IL6 TGFB1
21 response to amino acid GO:0043200 9.58 ARG1 CASP3 IL6
22 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
23 cellular response to lipopolysaccharide GO:0071222 9.55 ARG1 CXCL8 IL6 NOS2 TNF
24 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.54 IL6 TNF
25 cellular response to dexamethasone stimulus GO:0071549 9.54 ARG1 IL6 TGFB1
26 positive regulation of receptor binding GO:1900122 9.52 BDNF MMP9
27 peptidyl-cysteine S-nitrosylation GO:0018119 9.48 NOS1 NOS2
28 positive regulation of mononuclear cell migration GO:0071677 9.43 TGFB1 TNF
29 positive regulation of apoptotic process GO:0043065 9.17 CASP3 GRIN1 IL6 MMP9 NGFR TGFB1
30 arginine catabolic process GO:0006527 9.13 ARG1 NOS1 NOS2
31 negative regulation of apoptotic process GO:0043066 10.02 CASP3 GDNF IL6 MMP9 NGFR

Molecular functions related to Spinal Cord Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 CXCL8 IL6 TGFB1 TNF
2 calmodulin binding GO:0005516 9.62 GRIN1 NGFR NOS1 NOS2
3 growth factor activity GO:0008083 9.46 BDNF GDNF IL6 TGFB1
4 arginine binding GO:0034618 9.37 NOS1 NOS2
5 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS1 NOS2
6 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS2
7 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS2

Sources for Spinal Cord Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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