MCID: SPN186
MIFTS: 63

Spinal Cord Injury malady

Neuronal diseases, Rare diseases categories

Summaries for Spinal Cord Injury

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Sources:
35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. a spinal cord injury disrupts the signals. spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. most injuries don't cut through your spinal cord. instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. spinal cord injuries can be complete or incomplete. with a complete spinal cord injury, the cord can't send signals below the level of the injury. as a result, you are paralyzed below the injury. with an incomplete injury, you have some movement and sensation below the injury. a spinal cord injury is a medical emergency. immediate treatment can reduce long-term effects. treatments may include medicines, braces or traction to stabilize the spine, and surgery. later treatment usually includes medicines and rehabilitation therapy. mobility aids and assistive devices may help you to get around and do some daily tasks. nih: national institute of neurological disorders and stroke

MalaCards: Spinal Cord Injury, also known as spinal cord injuries, is related to wallerian degeneration and neuropathy. An important gene associated with Spinal Cord Injury is GDNF (glial cell derived neurotrophic factor), and among its related pathways are MSP-RON Signaling and Spinal Cord Injury. The compounds aminoglycosides and riluzole have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related mouse phenotypes are muscle and cellular.

NINDS:45 A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis.

Wikipedia:66 A spinal cord injury (SCI) refers to any injury to the spinal cord that is caused by trauma instead of... more...

Aliases & Classifications for Spinal Cord Injury

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Sources:
45NINDS, 50Orphanet, 32LifeMap Discoveryā„¢, 35MedlinePlus, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
spinal cord injury:
Prevalence: 1-5/10000


Aliases & Descriptions:

spinal cord injury 45 50 32
spinal cord injuries 35


External Ids:

ICD10 via Orphanet27 T09.3
SNOMED-CT via Orphanet60 90584004

Related Diseases for Spinal Cord Injury

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Spinal Cord Injury:



Diseases related to spinal cord injury

Symptoms for Spinal Cord Injury

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Drugs & Therapeutics for Spinal Cord Injury

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
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Approved drugs:

Search CenterWatch for Spinal Cord Injury

Drug clinical trials:

Search ClinicalTrials for Spinal Cord Injury

Search NIH Clinical Center for Spinal Cord Injury

Search CenterWatch for Spinal Cord Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Cord Injury cell therapies at LifeMap Discovery.

Genetic Tests for Spinal Cord Injury

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Anatomical Context for Spinal Cord Injury

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Spinal Cord Injury:

34
Spinal cord, Bone, Brain, Bone marrow, Prostate, Cortex, Skeletal muscle, Testes, Endothelial, Heart, Pituitary, Skin, Thyroid, Hypothalamus, Monocytes, Tongue, Colon, T cells, Pancreas, Testis, Ovary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Spinal Cord Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
4 Peripheral Nervous SystemPeripheral Nerve DomainMyelinating Schwann Cells Potential therapeutic candidate
5 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
6 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
7 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
8 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
13 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
15 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Spinal Cord Injury or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Spinal Cord Injury:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9FXYD1, CNTF, SOD1, DMD, GDNF
2MP:00053848.5GDNF, DMD, MPZ, SOD1, PARG, CNTF
3MP:00107688.0GDNF, DMD, MPZ, SOD1, PARG, CALCA
4MP:00053767.9DMD, MPZ, SOD1, PARG, CNTF, CALCA
5MP:00053867.9GDNF, DMD, GPR17, MPZ, SOD1, CNTF
6MP:00053857.8GDNF, DMD, GPR17, SOD1, CALCA, FXYD1
7MP:00036316.7ARTN, GDNF, DMD, GPR17, MPZ, SOD1

Publications for Spinal Cord Injury

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Sources:
53PubMed
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Articles related to Spinal Cord Injury:

(show top 50)    (show all 993)
idTitleAuthorsYear
1
Effects of the combined administration of vitamins C and E on the oxidative stress status and programmed cell death pathways after experimental spinal cord injury. (24247566)
2014
2
Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury. (24216616)
2014
3
Effects of a visuotemporal cue on walking ability of independent ambulatory subjects with spinal cord injury as compared with healthy subjects. (24394605)
2014
4
Mortality after lower extremity fractures in men with spinal cord injury. (23873733)
2014
5
The incorporation of growth factor and chondroitinase ABC into an electrospun scaffold to promote axon regrowth following spinal cord injury. (23950083)
2013
6
Prevalence and associated factors of T-score discordance between different sites in Iranian patients with spinal cord injury. (24296808)
2013
7
Spinal cord injury: Deep brain stimulation could provide a new approach for restoring motor function after spinal cord injury. (24217523)
2013
8
Residual pathways after spinal cord injury are not always clinically assessed. (24091761)
2013
9
Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. (24090150)
2013
10
Lower extremity functional electrical stimulation cycling promotes physical and functional recovery in chronic spinal cord injury. (24094120)
2013
11
Perceptions of gain following spinal cord injury: a qualitative analysis. (23960704)
2013
12
Bacteriuria and urinary tract infection after urodynamic examination of spinal cord injury patients. (23567758)
2013
13
Tetraplegia or paraplegia with brachial diparesis? What is the most appropriate designation for the motor deficit in patients with lower cervical spinal cord injury? (22825074)
2013
14
Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice. (23926264)
2013
15
Activation of heme oxygenase recovers motor function after spinal cord injury in rats. (24112949)
2013
16
Risk of Fall-Related Injuries among Ambulatory Participants with Spinal Cord Injury. (24244091)
2013
17
Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury. (23916821)
2013
18
Suicide Mortality After Spinal Cord Injury in the United States: Injury Cohorts Analysis. (24161272)
2013
19
HMGB1 Contributes to Regeneration After Spinal Cord Injury in Adult Zebrafish. (23996344)
2013
20
Baseline prevalence of heart diseases, hypertension, diabetes, and obesity in persons with acute traumatic spinal cord injury: potential threats in the recovery trajectory. (23960701)
2013
21
Functional effect of mouse embryonic stem cell implantation after spinal cord injury. (24278865)
2013
22
Selective inhibition of STAT1 reduces spinal cord injury in mice. (24321405)
2013
23
Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage. (24286176)
2013
24
High-Intensity Virtual-reality Arm plus FES-leg Interval Training in Individuals with Spinal Cord Injury. (24042615)
2013
25
MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury. (24042989)
2013
26
Age-related prevalence of low testosterone in men with spinal cord injury. (24090163)
2013
27
The SCIentinel study - prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS) - study protocol and interim feasibility data. (24206943)
2013
28
Animal models of axon regeneration after spinal cord injury. (23893429)
2013
29
Predictors of mortality in veterans with traumatic spinal cord injury. (23896672)
2013
30
Options for independent bladder management in patients with spinal cord injury and hand function prohibiting intermittent catheterization. (24151101)
2013
31
STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury. (23928811)
2013
32
Reappearance of sympathetic skin response below a thoracic level-9 complete spinal cord injury. (24359880)
2013
33
International survey of perceived barriers to admission and discharge from spinal cord injury rehabilitation units. (23896668)
2013
34
Cardiovascular Function After Spinal Cord Injury: Prevalence and Progression of Dysfunction During Inpatient Rehabilitation and 5 Years Following Discharge. (24243916)
2013
35
Use of platelet rich plasma for the treatment of bicipital tendinopathy in spinal cord injury:: a pilot study. (23459023)
2012
36
Muscle spasticity associated with reduced whole-leg perfusion in persons with spinal cord injury. (22330115)
2011
37
Spinal cord injury in cervical spinal stenosis by minor trauma. (20452868)
2010
38
The neuroprotective potential of phase II enzyme inducer on motor neuron survival in traumatic spinal cord injury in vitro. (17912625)
2008
39
Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. (18320028)
2008
40
Men with spinal cord injury have a smaller prostate than men without. (17454950)
2007
41
Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury? (15708030)
2005
42
Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. (14588118)
2003
43
Intrathecal baclofen therapy for spinal origin spasticity: spinal cord injury, spinal cord disease, and multiple sclerosis. (22151114)
1999
44
Osteoporosis after spinal cord injury. (9881730)
1998
45
Dramatic development of quadriplegia in a young man while engaged in heavy manual labour: a post-traumatic spinal cord injury? (9849865)
1998
46
Genetic influences on cellular reactions to spinal cord injury: activation of macrophages/microglia and astrocytes is delayed in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration. (8842900)
1996
47
Adhesion molecules and wound healing in spinal cord injury. (9031328)
1996
48
Vitamin D deficiency in veterans with chronic spinal cord injury. (8786732)
1995
49
Neural arch stenosis and spinal cord injury in thanatophoric dysplasia. (1985437)
1991
50
Telogen effluvium: hair loss after spinal cord injury. (6431941)
1984

Variations for Spinal Cord Injury

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Expression for genes affiliated with Spinal Cord Injury

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Cord Injury

Search GEO for disease gene expression data for Spinal Cord Injury.

Pathways for genes affiliated with Spinal Cord Injury

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database
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Pathways related to Spinal Cord Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6KLK8, KLK6
29.2KLK8, MIR23B, PRB1, GDNF

Compounds for genes affiliated with Spinal Cord Injury

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Spinal Cord Injury according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1aminoglycosides4610.3DMD, GDNF
2riluzole46 30 1212.3GDNF, SOD1
3n(g)-nitro-l-arginine methyl ester4610.2SOD1, CALCA
4ganglioside4610.1GDNF, MPZ, CNTF
5ng-nitro-l-arginine4610.0CALCA, SOD1
6selegiline46 1211.0SOD1, GDNF
7nitroglycerin46 1211.0CALCA, SOD1
8bromodeoxyuridine469.9CNTF, MPZ, DMD, GDNF
9acetylcholine46 52 30 25 1213.8GDNF, DMD, CNTF, CALCA
106-hydroxydopamine469.8ARTN, SOD1, GDNF
11adenylate469.7CALCA, CNTF, DMD, GDNF
12creatinine469.6GDNF, DMD, MPZ, SOD1, CALCA
13glutamate469.6CALCA, CNTF, SOD1, MPZ, GDNF
14nitric oxide46 25 1211.6GDNF, DMD, SOD1, CNTF, CALCA
15dopamine46 30 25 1212.5GDNF, CNTF, CALCA, ARTN
16cyclic amp46 2510.3GDNF, CNTF, CALCA, FXYD1
17h2o2469.2GDNF, SOD1, PARG, CNTF
18lipid469.0CNTF, SOD1, MPZ, DMD, GDNF
19serine468.9KLK8, KLK6, CNTF, MPZ, DMD, GDNF

GO Terms for genes affiliated with Spinal Cord Injury

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Sources:
17Gene Ontology
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Cellular components related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5ARTN, KLK8, CALCA, CNTF, NENF, SOD1

Biological processes related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to heatGO:00940810.0CALCA, SOD1
2regulation of heart rateGO:0020279.9DMD, CALCA
3negative regulation of neuron apoptotic processGO:0435249.9CNTF, SOD1, GDNF
4tissue regenerationGO:0422469.7NINJ1, KLK6
5embryo implantationGO:0075669.7CALCA, SOD1

Molecular functions related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2ARTN, CNTF, NENF, GDNF

Products for genes affiliated with Spinal Cord Injury

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  • Antibodies
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Sources for Spinal Cord Injury

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet