MCID: SPN186
MIFTS: 63

Spinal Cord Injury malady

Neuronal category

Summaries for Spinal Cord Injury

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. a spinal cord injury disrupts the signals. spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. most injuries don't cut through your spinal cord. instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. spinal cord injuries can be complete or incomplete. with a complete spinal cord injury, the cord can't send signals below the level of the injury. as a result, you are paralyzed below the injury. with an incomplete injury, you have some movement and sensation below the injury. a spinal cord injury is a medical emergency. immediate treatment can reduce long-term effects. treatments may include medicines, braces or traction to stabilize the spine, and surgery. later treatment usually includes medicines and rehabilitation therapy. mobility aids and assistive devices may help you to get around and do some daily tasks. nih: national institute of neurological disorders and stroke

MalaCards: Spinal Cord Injury, also known as spinal cord injuries, is related to wallerian degeneration and adenocarcinoma. An important gene associated with Spinal Cord Injury is MPZ (myelin protein zero), and among its related pathways are Spinal Cord Injury and NgR-p75(NTR)-Mediated Signaling. The compounds glutamate and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are nervous system and behavior/neurological.

NINDS:44 A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis.

Wikipedia:64 A spinal cord injury (SCI) refers to any injury to the spinal cord that is caused by trauma instead of... more...

Aliases & Classifications for Spinal Cord Injury

Sources:
44NINDS, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
spinal cord injury:
Prevalence: 1-5/10000


Aliases & Descriptions:

spinal cord injury 44 49 31
spinal cord injuries 34


External Ids:

ICD10 via Orphanet26 T09.3
SNOMED-CT via Orphanet58 90584004

Related Diseases for Spinal Cord Injury

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Spinal Cord Injury:



Diseases related to spinal cord injury

Clinical Features for Spinal Cord Injury

Drugs & Therapeutics for Spinal Cord Injury

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Spinal Cord Injury

Drug clinical trials:

Search ClinicalTrials for Spinal Cord Injury

Search NIH Clinical Center for Spinal Cord Injury

Search CenterWatch for Spinal Cord Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Cord Injury cell therapies at LifeMap Discovery.

Genetic Tests for Spinal Cord Injury

Anatomical Context for Spinal Cord Injury

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Spinal Cord Injury:

33
Bone marrow, Whole blood, Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Skin, Ovary, Prostate, Testis, Monocytes, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal thyroid, Adrenal cortex, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Spinal Cord Injury:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
4 Peripheral Nervous SystemPeripheral Nerve DomainMyelinating Schwann Cells Potential therapeutic candidate
5 Neural TubedP5 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
6 Neural TubeCaudal Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
7 Neural TubedP3 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
8 Neural TubeLateral Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural TubeMotor Neural Progenitor DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural TubeAnterior Entopeduncular AreaOligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural TubeMedial Ganglionic EminenceOligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural TubedP4 Neural DomainOligodendrocyte Precursor Cells Potential therapeutic candidate
13 BrainForebrain White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
14 Spinal CordSpinal Cord White MatterOligodendrocyte Precursor Cells Potential therapeutic candidate
15 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Spinal Cord Injury or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Spinal Cord Injury:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.8CNTF, RTN4R, GFRA3, OLIG1, NGFR, AQP4
2MP:000538611.5GDNF, KLK8, CALCA, SOD1, PDYN, AQP4
3MP:000537611.4NGFR, KLK8, SOD1, PDYN, ARG1, DMD
4MP:000538411.2GDNF, NGFR, MPZ, RTN4R, CNTF, DMD
5MP:000537710.6SOD1, DMD, NGFR, AQP4, CALCA

Publications for Spinal Cord Injury

Sources:
51PubMed
See all sources

Articles related to Spinal Cord Injury:

(show top 50)    (show all 1108)
idTitleAuthorsYear
1
Anti-inflammatory and Antiapoptotic Effect of Interleukine-18 Binding Protein on the Spinal Cord Ischemia-Reperfusion Injury. (24429913)
2014
2
Human spinal cord injury: motor unit properties and behaviour. (23901835)
2014
3
Extradural Nerve Anastomosis Technique for Bladder Reinnervation in Spinal Cord Injury: Anatomical Feasibility Study in Human Cadavers. (24430721)
2014
4
Clinical correlates of cerebral diffusion tensor imaging findings in chronic traumatic spinal cord injury. (24418961)
2014
5
Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling. (24090150)
2013
6
Risk of Fall-Related Injuries among Ambulatory Participants with Spinal Cord Injury. (24244091)
2013
7
Plain abdominal radiograph as an evaluation method of bowel dysfunction in patients with spinal cord injury. (24020036)
2013
8
Intractable abdominal pain in a patient with spinal cord injury: a case report. (24236262)
2013
9
Magnitude of forward trunk flexion influences upper limb muscular efforts and dynamic postural stability requirements during sitting pivot transfers in individuals with spinal cord injury. (24094473)
2013
10
Effects of bone marrow stromal cell transplantation through CSF on the subacute and chronic spinal cord injury in rats. (24039961)
2013
11
The impact of mild traumatic brain injury on cognitive functioning following co-occurring spinal cord injury. (24055885)
2013
12
Effects of electromyostimulation on muscle and bone in men with acute traumatic spinal cord injury: A randomized clinical trial. (24090427)
2013
13
Randomized trial of functional electrical stimulation therapy for walking in incomplete spinal cord injury: effects on quality of life and community participation. (24244090)
2013
14
A lesson in continence from spinal cord injury. (24104992)
2013
15
Mechanical ventilation weaning and extubation after spinal cord injury: a Western Trauma Association multicenter study. (24256682)
2013
16
Prolonged electrical stimulation-induced gluteal and hamstring muscle activation and sitting pressure in spinal cord injury: effect of duty cycle. (24301439)
2013
17
Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition. (23541432)
2013
18
Influenza infection control guidance provided to staff at Veterans Affairs facilities for veterans with spinal cord injury during a pandemic(a8 ). (24090346)
2013
19
Use, performance and features of mobile shower commodes: perspectives of adults with spinal cord injury and expert clinicians. (24003959)
2013
20
Spinal Cord Injury due to the Giant Cell Tumor of the Second Thoracic Vertebra: A Case Report. (23705124)
2013
21
Effect of pretreatment with simvastatin on spinal cord ischemia-reperfusion injury in rats. (22445180)
2013
22
Ascending curbs of progressively higher height increases forward trunk flexion along with upper extremity mechanical and muscular demands in manual wheelchair users with a spinal cord injury. (23866992)
2013
23
Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. (24068802)
2013
24
Neurobiological perspective of spasticity as occurs after a spinal cord injury. (22342316)
2012
25
Intermittent catheterization in the management of post spinal cord injury (SCI) neurogenic bladder using new hydrophilic, with lubrication in close circuit devices--our own preliminary results. (22574083)
2012
26
Supratrigonal cystectomy with Hautmann pouch as treatment for neurogenic bladder in spinal cord injury patients: long-term functional results. (22532256)
2012
27
International spinal cord injury pulmonary function basic data set. (22270192)
2012
28
Electroejaculatory stimulation for male infertility secondary to spinal cord injury: the Irish experience in National Rehabilitation Hospital. (20932558)
2011
29
Global gene expression analysis of rodent motor neurons following spinal cord injury associates molecular mechanisms with development of postinjury spasticity. (19939961)
2010
30
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. (19884507)
2010
31
Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK. (19383246)
2009
32
Relationship between median nerve somatosensory evoked potentials and spinal cord injury levels in patients with quadriplegia. (19153589)
2009
33
Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms. (18947003)
2008
34
Optimal treatment for severe neurogenic bowel dysfunction after chronic spinal cord injury: a decision analysis. (17535012)
2007
35
IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. (16184194)
2005
36
Health-related quality of life of patients using clean intermittent catheterization for neurogenic bladder secondary to spinal cord injury. (15708043)
2005
37
Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. (15567326)
2004
38
Neuroprotective effects of FK-506, L-carnitine and azathioprine on spinal cord ischemia-reperfusion injury. (14690740)
2004
39
Preserved granulocyte formation and function, as well as bone marrow innervation, in subjects with complete spinal cord injury. (15352992)
2004
40
Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. (14588118)
2003
41
Prevalence of vitamin B12 deficiency in spinal cord injury. (14639569)
2003
42
The effects of L-carnitine on spinal cord ischemia/reperfusion injury in rabbits. (11847597)
2002
43
Facilitation of immune function, healing of pressure ulcers, and nutritional status in spinal cord injury patients. (10640453)
2000
44
Apoptotic cells associated with Wallerian degeneration after experimental spinal cord injury: a possible mechanism of oligodendroglial death. (10547103)
1999
45
Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment. (9326288)
1997
46
Autonomic dysreflexia and detrusor-sphincter dyssynergia in spinal cord injury patients. (9261785)
1997
47
Immune system-neuroendocrine dysregulation in spinal cord injury. (8988397)
1996
48
Management of bowel dysfunction in children with spinal cord disease or injury by means of the enema continence catheter. (1735813)
1992
49
Pharmacologic strategies in the treatment of experimental spinal cord injury. (1588610)
1992
50
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989

Genetic Variations for Spinal Cord Injury

Expression for genes affiliated with Spinal Cord Injury

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spinal Cord Injury

Search GEO for disease gene expression data for Spinal Cord Injury.

Pathways for genes affiliated with Spinal Cord Injury

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome
See all sources

Pathways related to Spinal Cord Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.1AQP4, KLK8, PDYN, ARG1, NGFR, GDNF
210.7RTN4R, NGFR, ARG1
3
Hide members
10.6RTN4R, NGFR

Compounds for genes affiliated with Spinal Cord Injury

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Spinal Cord Injury according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1glutamate4511.6AQP4, CALCA, SOD1, PDYN, ARG1, MPZ
2nitric oxide45 11 2413.5CALCA, SOD1, PDYN, ARG1, DMD, CNTF
3cysteine4511.4SOD1, PDYN, DMD, MPZ, NGFR, GDNF
4acetylcholine45 50 29 11 2415.4CALCA, PDYN, DMD, CNTF, NGFR, GDNF
5lipid4511.3SOD1, PDYN, DMD, MPZ, CNTF, NGFR
6cyclic amp45 2412.3CALCA, ARG1, CNTF, NGFR, GDNF, FXYD1
7arginine4511.3SOD1, PDYN, ARG1, DMD, MPZ, CNTF
8zinc45 2412.3SOD1, PDYN, DMD, NGFR, GDNF, RTN4R
9potassium45 11 2413.2PDYN, DMD, CNTF, GDNF, AQP4
10dopamine45 29 11 2414.2CALCA, PDYN, CNTF, NGFR, GDNF
11ganglioside4511.2GDNF, NGFR, CNTF, MPZ
12catecholamine4511.2PDYN, CNTF, NGFR, GDNF
13bromodeoxyuridine4511.2GDNF, CNTF, MPZ, DMD
14creatinine4511.2GDNF, MPZ, DMD, SOD1, CALCA
15adenylate4511.1CALCA, PDYN, DMD, CNTF, GDNF
16amphetamine45 1112.1PDYN, CNTF, GDNF
17gaba4511.0PDYN, CNTF, NGFR, GDNF
186-hydroxydopamine4511.0SOD1, PDYN, GDNF
19tellurium4511.0NGFR, MPZ
20capsaicin45 2912.0CALCA, PDYN, GDNF
21serine4511.0KLK6, KLK8, DMD, MPZ, CNTF, NGFR
22ethanol45 50 11 2413.9PDYN, NGFR, GDNF, RTN4IP1
23oligonucleotide4510.9AQP4, GDNF, NGFR, DMD, PDYN
24norepinephrine45 11 2412.9CALCA, PDYN, CNTF, GDNF
25levodopa45 1111.9GDNF, PDYN, SOD1
26aminoglycosides4510.8GDNF, DMD
27riluzole45 29 1112.8SOD1, GDNF
28histamine45 29 2412.8AQP4, NGFR, CNTF, CALCA
29steroid4510.6KLK6, KLK8, PDYN, MPZ, NGFR

GO Terms for genes affiliated with Spinal Cord Injury

Sources:
16Gene Ontology
See all sources

Cellular components related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0CNTF, NENF, ARG1, SOD1, CALCA, KLK8

Biological processes related to Spinal Cord Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nervous system developmentGO:00739910.9AQP4, GFRA3, GDNF, NINJ1
2negative regulation of neuron apoptotic processGO:04352410.7SOD1, CNTF, GDNF
3negative regulation of axonogenesisGO:05077110.6RTN4R, NGFR
4tissue regenerationGO:04224610.5KLK6, NINJ1
5muscle cell cellular homeostasisGO:04671610.3DMD, SOD1

Products for genes affiliated with Spinal Cord Injury

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spinal Cord Injury

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet