Spinal Cord Injury malady

NINDS: A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis.³¹

MalaCards: Spinal Cord Injury, also known as spinal cord injuries, is related to orthostatic hypotension and myelomeningocele. An important gene associated with Spinal Cord Injury is NENF (neudesin neurotrophic factor), and among its related pathways are Apoptosis and Autophagy and Colorectal cancer. The compounds glucose and citrate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord, and related mouse phenotypes are respiratory system and renal/urinary system.

MedlinePlus: Spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. most injuries don't sever your spinal cord. instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. in a complete spinal cord injury, the cord can't relay messages below the level of the injury. as a result, you are paralyzed below the level of injury. in an incomplete injury, you have some movement and sensation below the injury. a spinal cord injury is a medical emergency. immediate treatment can reduce long-term effects. later treatment usually includes medicine and rehabilitation therapy. nih: national institute of neurological disorders and stroke²³

Wikipedia: A spinal cord injury (SCI) refers to any injury to the spinal cord that is caused by trauma instead of...⁴⁴ more...

spinal cord injury 31 spinal cord injuries 23

Diseases related to spinal cord injury by text searches and GeneDecks gene sharing:

(show top 50)    (show all 972)

id	Related Disease	Score	Top Affiliating Genes
1	orthostatic hypotension	30.7	REN, ALB, CALCA, SST, POMC, ADRB2
2	myelomeningocele	30.4	BGLAP, LEP, MTHFR, IGF1, TPPP3, PRL
3	hepatitis	30.3	ARG1, GSR, GPT, F2, ALB, TNFRSF1A
4	paralysis	29.9	PIK3C2A, PDE4A, CNTF, MPZ, INS, IL10
5	gliosis	29.3	CNTF, MPZ, FOS, IL6, AQP4, MBP
6	hepatitis c	27.7	JUN, CD69, GSR, IL10, IL2, IL4
7	deep vein thrombosis	27.3	SERPINC1, SERPINE1, MTHFR, FGA, GPT, F8
8	squamous cell carcinoma	26.5	PIN1, GC, BIRC5, CLU, PARP1, BCL2
9	respiratory failure	26.4	PIK3C2A, REN, SERPINC1, SERPINA7, INS, IL10
10	proteinuria	25.6	PIK3C2A, COG2, REN, SERPINC1, SERPINE1, NAGLU
11	neuronitis	23.2	PIK3C2A, PIN1, PDE4A, REN, CNP, CNTF
12	thrombosis	22.9	PIK3C2A, COG2, REN, SERPINC1, SERPINE1, BGLAP
13	osteoporosis	22.6	PDE4A, GC, SERPINC1, BGLAP, LEP, MTHFR
14	cervicitis	21.6	PIN1, PDE4A, REN, GC, SERPINC1, SERPINE1
15	blindness	20.5	PIK3C2A, COG2, PDE4A, REN, CNTF, SERPINC1
16	coronary heart disease	20.1	PIK3C2A, COG2, SERPINC1, SERPINE1, CLU, BGLAP
17	multiple sclerosis	18.8	PDE4A, CNP, CNTF, GC, SERPINC1, SERPINE1
18	prostatitis	18.6	PIK3C2A, PIN1, PDE4A, CNTF, GC, SERPINC1
19	obesity	18.3	PIK3C2A, COG2, REN, CNTF, GC, SERPINC1
20	atherosclerosis	17.7	PIK3C2A, COG2, PDE4A, REN, SERPINC1, SERPINE1
21	leukemia	16.4	PIK3C2A, PIN1, COG2, PDE4A, REN, CNTF
22	carcinoma	16.2	PIK3C2A, PIN1, PDE4A, REN, CNTF, GC
23	thyroiditis	15.9	PIK3C2A, PIN1, COG2, PDE4A, REN, GC
24	temporal lobe epilepsy	14.2	BDNF, AQP4, HTR1A, NTF3, PDYN, GFAP
25	muscular atrophy	14.2	CNTF, PARP1, BCL2, BAD, MPZ, FBXO32
26	cognitive disease	14.1	BDNF, APOE, HTR1A, DMD, GABBR1, GAL
27	basal cell carcinoma	14.0	BCL2, LGALS1, LAMC2, CD34, ITGB4, MCL1
28	huntington's disease	14.0	CNTF, PARP1, BDNF, SDHB, GRIN2A, CASP3
29	postpartum depression	14.0	BDNF, HTR1A, CALCA, CRH, PRL
30	diabetic neuropathy	14.0	CNTF, MPZ, INS, NTF3, NGFR, GAD1
31	b-cell lymphomas	14.0	BIRC5, CLU, PARP1, BCL2, BAD, XIAP
32	memory impairment	13.9	PDE4A, BDNF, APOE, HTR1A, HTR2A, PDYN
33	tardive dyskinesia	13.9	BDNF, APOE, HTR2A, NOS1, PRL, SOD1
34	anxiety disorder	13.9	BDNF, HTR1A, HTR2A, CRH, GABBR1, GAD1
35	status epilepticus	13.9	CNP, CNTF, BDNF, JUN, FOS, CASP3
36	seasonal affective disorder	13.9	HTR1A, HTR2A, CRH, PRL, POMC, GABBR1
37	brain cancer	13.8	PDE4A, CNTF, BIRC5, CLU, LGALS1, FGF2
38	osteomalacia	13.8	GC, CLU, BGLAP, CD36, ALPP, CALCA
39	endogenous depression	13.8	BDNF, HTR1A, CRH, GAD1
40	granular cell tumor	13.8	BCL2, MPZ, MBP, IGF1, CASP3, NGFR
41	hypocalcemia	13.8	PIK3C2A, BGLAP, CD36, ALB, ALPP, CALCA
42	neurilemmoma	13.8	MPZ, CD34, ITGB4, MBP, NTF3, NGFR
43	hirschsprung's disease	13.8	ARTN, HMOX2, NTF3, NOS1, NGFR, GDNF
44	frontotemporal dementia	13.8	PIN1, BDNF, JUN, APOE, RPS27A, GFAP
45	borderline personality disorder	13.8	BGLAP, BDNF, IL6, HTR1A, HTR1B, HTR2A
46	meningitis and encephalitis	13.7	NTF3, CRP, SOD1, GDNF
47	premature ejaculation	13.7	PDE4A, LEP, HTR1A, HTR1B, LSL, PRL
48	osteopenia/osteoporosis	13.7	BGLAP, IGF1, CALCA, TNFRSF11B, SLPI
49	attention deficit hyperactivity disorder	13.7	BDNF, MTHFR, FOS, GRIN2A, HTR1A, HTR1B
50	substance abuse	13.7	BDNF, GPT, IGF1, HTR1A, HTR1B, CRH

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to spinal cord injury:

²²

MGI Mouse Phenotypes related to spinal cord injury:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.8	CNP, BDNF, P2RX2, AQP4, APOE, CALCA
2	renal/urinary system phenotype	MP:0005367	10.3	REN, NAGLU, CLU, BCL2, UPK3A, LAMC2
3	hematopoietic system phenotype	MP:0005397	10.2	CNTF, BCL2, BAD, XIAP, P2RX7, CD69
4	craniofacial phenotype	MP:0005382	10.1	NAGLU, BDNF, LAMA3, CASP9, PTPRS, NFE2L2
5	no phenotypic analysis	MP:0003012	10.0	PARP1, BDNF, MTHFR, CD69, INS, AQP4
6	endocrine/exocrine gland phenotype	MP:0005379	10.0	CNP, PARG, BCL2L2, IL2, IFNG, HTR1B
7	taste/olfaction phenotype	MP:0005394	9.9	PDE4A, BDNF, MAPK1, CASP3, CASP9, PTPRS
8	other phenotype	MP:0005395	9.8	CLU, LAMC2, IL2, APOE, TNFRSF1A, PTGER2
9	embryogenesis phenotype	MP:0005380	9.5	SERPINC1, BIRC5, PARP1, UBC, FOS, F2
10	liver/biliary system phenotype	MP:0005370	9.5	SERPINC1, CD36, INS, FGA, IL2, IL6
11	hearing/vestibular/ear phenotype	MP:0005377	9.3	NAGLU, MYO1A, PARP1, BDNF, BCL2, LAMC2
12	integument phenotype	MP:0010771	8.9	PIN1, PARP1, BDNF, BCL2, LGALS1, LAMA3
13	immune system phenotype	MP:0005387	8.6	PDE4A, REN, CNP, CNTF, NAGLU, CLU
14	digestive/alimentary phenotype	MP:0005381	8.0	CNP, MYO1A, BDNF, BCL2, LEP, LAMA3
15	nervous system phenotype	MP:0003631	8.0	PDE4A, REN, CNP, CNTF, SERPINC1, NAGLU
16	reproductive system phenotype	MP:0005389	7.3	REN, CNP, LEP, BAD, MPZ, MMP9
17	normal phenotype	MP:0002873	7.0	REN, BDNF, LGALS1, XIAP, FOS, ARG1
18	adipose tissue phenotype	MP:0005375	7.0	PIK3C2A, SERPINE1, BCL2, LEP, UCP1, ATRN
19	growth/size phenotype	MP:0005378	7.0	PIK3C2A, PIN1, REN, CNP, SERPINE1, NAGLU
20	mortality/aging	MP:0010768	6.8	PIK3C2A, REN, CNP, SERPINC1, SERPINE1, NAGLU
21	skeleton phenotype	MP:0005390	6.7	CNP, GC, NAGLU, LEP, MTHFR, LAMC2
22	muscle phenotype	MP:0005369	5.9	REN, CNP, CNTF, CLU, BCL2, LGALS1
23	tumorigenesis	MP:0002006	5.9	SERPINE1, BCL2, LEP, BAD, CD34, MMP2
24	behavior/neurological phenotype	MP:0005386	5.8	REN, CNP, CNTF, NAGLU, BDNF, BCL2L2
25	vision/eye phenotype	MP:0005391	5.5	PIN1, CNP, SERPINC1, NAGLU, BDNF, BCL2
26	homeostasis/metabolism phenotype	MP:0005376	4.4	PIK3C2A, REN, CNP, CNTF, GC, SERPINC1
27	cellular phenotype	MP:0005384	3.5	PIN1, CNTF, NAGLU, BIRC5, PARP1, PARG
28	cardiovascular system phenotype	MP:0005385	2.3	PDE4A, REN, SERPINC1, SERPINE1, NAGLU, CLU

Articles related to spinal cord injury:

(show top 50)    (show all 172)

id	Title	Authors	Year	Affiliating Genes
1	A new role for RPTPsigma in spinal cord injury: signa ling chondroitin sulfate proteoglycan inhibition. (20179269)	Duan Y.... Giger R.J.	2010	PTPRS
2	Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. (19884507)	Lee H.... Bellamkonda R.V.	2010	NTF3
3	Involvement of ERK2 in traumatic spinal cord injury. (20067580)	Yu C.G.... Geddes J.W.	2010	MAPK1
4	Erythropoietin in spinal cord injury. (19030901)	Matis G.K.... Birbilis T.A.	2009	EPO
5	Risk factors for failure of heparin thromboprophylaxi s in patients with acute traumatic spinal cord injury. (19853891)	Rubin-Asher D.... Lubetsky A.	2009	F2, F8, F5
6	Expression of purinergic P2X2-receptors in neurogenic bladder dysfunction due to spinal cord injury: a preliminary immunohistochemic al study. (19104511)	Pannek J.... Tannapfel A.	2009	P2RX2
7	The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. (19528093)	Ceruti S.... Abbracchio M.P.	2009	GPR17
8	Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. (19324014)	Liu X.... Yamashita T.	2009	RGMB
9	HSV-mediated transfer of artemin overcomes myelin inh ibition to improve outcome after spinal cord injury. (19293775)	Zhou Z.... Mata M.	2009	ARTN, GFRA3
10	Age and motor score predict osteoprotegerin level in chronic spinal cord injury. (18398265)	Morse L.R.... Garshick E.	2008	TNFRSF11B
11	Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury. (18209743)	Maruyama Y.... Hosoya T.	2008	LSL
12	Role of free radicals and poly(ADP-ribose)polymerase-1 in the development of spinal cord injury: new potential therapeutic targets. (18289003)	Genovese T.... Cuzzocrea S.	2008	PARP1, EPRS, PARG
13	Infusion of human umbilical cord blood cells ameliora tes hind limb dysfunction in experimental spinal cord injury through anti-infla mmatory, vasculogenic and neurotrophic mechanisms. (18947003)	Chen C.T.... Chen S.H.	2008	GDNF, IL10
14	Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. (17699671)	Zhao P.... Hains B.C.	2007	MAPK1, CCL21
15	Circulating levels of markers of inflammation and endothelial activation are increased in men with chronic spinal cord injury. (18063513)	Wang T.D.... Chen S.Y.	2007	IL6, ALB, CRP
16	Transient suppression of the vesicular acetylcholine transporter in urinary bladder pathways following spinal cord injury. (17229408)	Takahara Y.... Kiyama H.	2007	SLC18A3
17	The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury. (17706365)	Chu G.K.... Fehlings M.G.	2007	NGFR
18	WITHDRAWN: Association between polymorphisms in genes of inflammatory response and axonal repair with spinal cord injury. (17893696)	Guimaraes P.E.... Teixeira W.G.	2007	BDNF, APOE, ALOX12
19	Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. (17578450)	Penas C.... Casas C.	2007	EPHA3
20	Alterations in mRNA expression and protein products following spinal cord injury in humans. (17218363)	Urso M.L.... Clarkson P.M.	2007	FBXO32
21	Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury. (16198696)	Vizzard M.A.	2006	NOS1, GAL
22	Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury. (16739558)	Zimmer M.B.... Goshgarian H.G.	2006	HTR1A
23	Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial. (16703907)	Kotil K.... Bilge T.	2006	ADC
24	Beta2-adrenoreceptor agonist-enhanced recovery of locomotor function after spinal cord injury is glutathione dependent. (16503801)	Zeman R.J.... Etlinger J.D.	2006	GSR
25	Leukemia inhibitory factor arrests oligodendrocyte death and demyelination in spinal cord injury. (16957585)	Azari M.F.... Petratos S.	2006	MBP
26	High seminal platelet-activating factor acetylhydrolase activity in men with spinal cord injury. (16339448)	Zhu J.... Roudebush W.E.	2006	PLA2G7
27	Testosterone levels among men with spinal cord injury admitted to inpatient rehabilitation. (16865023)	Schopp L.H.... Childers M.K.	2006	ALB, TTR
28	Inflammatory and apoptotic signaling after spinal cord injury. (16629620)	Keane R.W.... Dietrich W.D.	2006	TNFRSF1A
29	Spinal synaptic enhancement with acute intermittent h ypoxia improves respiratory function after chronic cervical spinal cord injury. (15772352)	Golder F.J.... Mitchell G.S.	2005	HTR2A
30	Efficacy of BTA stat, cytology, and survivin in bladder cancer surveillance over 5 years in patients with spinal cord injury. (16230180)	Davies B.... Getzenberg R.H.	2005	BIRC5
31	The nitrosteroid NCX 1015, a prednisolone derivative, improves recovery of function in rats after spinal cord injury. (16263098)	Mallei A.... Mocchetti I.	2005	TNF
32	Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rat s. (15872102)	Choi H.... Teng Y.D.	2005	HTR1A
33	Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts. (16091415)	Seitz A.... Heber-Katz E.	2005	APOE
34	Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries. (14760011)	Basu S.... Brackett N.L.	2004	TGFB1, TNF, IL6
35	Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. (15233942)	Liu J.... Fink D.J.	2004	GAD1
36	Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. (15016081)	Davies J.E.... Davies S.J.	2004	DCN
37	Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. (15152026)	Gu B.... Dolber P.C.	2004	HTR1B, HTR1A
38	Transplantation of human umbilical cord stem cells improves neurological function recovery after spinal cord injury in rats (15052772)	Li H.J.... Han Z.C.	2004	GFAP
39	Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury. (15262419)	Taylor S.J.... Sakiyama-Elbert S.E.	2004	NTF3
40	Rubrospinal neurons fail to respond to brain-derived neurotrophic factor applied to the spinal cord injury site 2 months after cervical axotomy. (15296835)	Kwon B.K.... Tetzlaff W.	2004	BDNF, GAP43
41	Preserved granulocyte formation and function, as well as bone marrow innervation, in subjects with complete spinal cord injury. (15352992)	Iversen P.O.... Benestad H.B.	2004	CD69
42	Incidence and clinical correlates of increased serum creatine kinase levels in persons with spinal cord injury. (12214901)	Szlachcic Y.... Greenwood J.	2002	PIK3C2A
43	Cellular and molecular alterations in spinal cord injury patients with pressure ulcers: a preliminary report. (11890721)	Cruse J.M.... Dilioglou S.	2002	LAMC2, ITGB4
44	Risk factors for development of proteinuria in chronic spinal cord injury. (10213646)	Wall B.M.... Cooke C.R.	1999	ALB
45	Adrenal and pituitary hormone patterns after spinal cord injury. (10418843)	Campagnolo D.I.... Keller S.E.	1999	POMC, PRL
46	Static exercise-induced increase in blood pressure in individuals with cervical spinal cord injury. (10084436)	Yamamoto M.... Ogata H.	1999	REN
47	Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury. (10506519)	Brewer K.L.... Yezierski R.P.	1999	IL10
48	Apoptosis after traumatic human spinal cord injury. (9833815)	Emery E.... Levi A.D.	1998	CASP3, CNP, CARD16
49	Central dysesthesia pain after traumatic spinal cord injury is dependent on N-methyl-D-aspartate receptor activation. (8584148)	Eide P.K.... Stenehjem A.E.	1995	OPRM1
50	Orthostatic hypotension after spinal cord injury: treatment with fludrocortisone and ergotamine. (1985624)	Groomes T.E.... Huang C.T.	1991	REN

Genes related to spinal cord injury according to GeneCards:

(show top 50)    (show all 170)

id	Symbol	Description	Score	GeneCards Section Context
1	NENF	neudesin neurotrophic factor	11.1	Aliases & Descriptions
2	RTN4IP1	reticulon 4 interacting protein 1	11.1	Functions, Summaries
3	GDNF	glial cell derived neurotrophic factor	11.1	Publications
4	MPZ	myelin protein zero	11.1	Publications
5	CNTF	ciliary neurotrophic factor	11.1	Publications
6	BAD	BCL2-associated agonist of cell death	11.1	Publications
7	CALCA	calcitonin-related polypeptide alpha	11.1	Publications
8	APOE	apolipoprotein E	11.1	Publications
9	PARP1	poly (ADP-ribose) polymerase 1	11.1	Publications
10	DMD	dystrophin	11.1	Publications
11	PRL	prolactin	11.1	Publications
12	BCL2	B-cell CLL/lymphoma 2	11.1	Publications
13	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.1	Publications
14	SOD1	superoxide dismutase 1, soluble	11.1	Publications
15	OLIG1	oligodendrocyte transcription factor 1	11.0	Publications
16	SPRR1A	small proline-rich protein 1A	11.0	Publications
17	NINJ1	ninjurin 1	11.0	Publications
18	FBXL16	F-box and leucine-rich repeat protein 16	11.0	Orthologs
19	GPR17	G protein-coupled receptor 17	11.0	Publications
20	GFRA3	GDNF family receptor alpha 3	11.0	Publications
21	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	11.0	Publications
22	RGMB	RGM domain family, member B	11.0	Publications
23	UPK3A	uroplakin 3A	11.0	Publications
24	NRN1	neuritin 1	11.0	Publications
25	ARTN	artemin	11.0	Publications
26	PARG	poly (ADP-ribose) glycohydrolase	11.0	Publications
27	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
28	P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	11.0	Publications
29	KLK8	kallikrein-related peptidase 8	11.0	Functions
30	RTN4R	reticulon 4 receptor	11.0	Publications
31	KLK6	kallikrein-related peptidase 6	11.0	Functions, Publications
32	PYCARD	PYD and CARD domain containing	11.0	Publications
33	FOSB	FBJ murine osteosarcoma viral oncogene homolog B	11.0	Publications
34	SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	11.0	Publications
35	ADC	arginine decarboxylase	11.0	Publications
36	CARD16	caspase recruitment domain family, member 16	11.0	Publications
37	BCL2L2	BCL2-like 2	11.0	Publications
38	MYO1A	myosin IA	11.0	Publications
39	FBXO32	F-box protein 32	11.0	Publications
40	AQP4	aquaporin 4	11.0	Publications
41	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
42	CCL21	chemokine (C-C motif) ligand 21	11.0	Publications
43	ARG1	arginase, liver	11.0	Publications
44	ZP3	zona pellucida glycoprotein 3 (sperm receptor)	11.0	Publications
45	HMOX2	heme oxygenase (decycling) 2	11.0	Publications
46	ALOX12	arachidonate 12-lipoxygenase	11.0	Publications
47	NTF3	neurotrophin 3	11.0	Publications
48	DCN	decorin	11.0	Publications
49	CSPG4	chondroitin sulfate proteoglycan 4	11.0	Publications
50	AIMP1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	11.0	Publications

Pathways related to spinal cord injury according to GeneDecks:

(show top 50)    (show all 157)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and Autophagy3	10.4	XIAP, MCL1, CASP1, CASP9, TNFRSF1A, PYCARD
2	Colorectal cancer20	10.3	TGFB2, TGFB1, CASP9, BAD, FOS
3	Glioma Invasiveness36	10.0	TGFB2, TGFA, FGF2, HGF, ITGB4, NTF3
4	OX40 Pathway36	9.6	NFKBIA, MAPK10, IL4, JUN, BCL2, LTA
5	Amoebiasis20	9.6	LAMC2, LAMA3, ARG1, IL6, NOS2, TGFB1
6	TNF Superfamily Pathway36	9.4	TNF, NFKBIA, TNFRSF1A, LTA, JUN, MAPK10
7	14-3-3 Induced Apoptosis36	9.4	LTA, NFKBIA, TNFRSF1A, CASP9, CASP1, CASP3
8	Toxoplasmosis20	9.3	TGFB1, IL10, TGFB2, NOS2, BCL2, BAD
9	Cellular Transformation by HTLV136	9.2	NFKBIA, LTA, SRF, TNFRSF1A, TNF, IFNG
10	Immune response_MIF-mediated glucocorticoid regulation41	8.7	NR3C1, JUN, FOS, IL6, MAPK1, IFNG
11	Immune response MIF-mediated glucocorticoid regulation10	8.7	NOS2, NFKBIA, NR3C1, JUN, FOS, IL2
12	Molecular Mechanisms of Cancer36	8.7	JUN, LTA, TGFA, TGFB1, TGFB2, HGF
13	Pathways in cancer20	8.6	BIRC5, BCL2, BAD, JUN, HGF, TGFB1
14	Akt Signaling36	8.6	NRG1, NTF3, CASP9, TNFRSF1A, TNF, ITGB4
15	Mitochondrial Apoptosis36	8.5	FGF2, IL2, IGF1, CASP3, CASP9, NTF3
16	Endothelin-1 Signaling Pathway36	8.4	CASP1, NOS1, PF4, EDN1, EDNRA, EPHA3
17	PEDF Induced Signaling36	8.4	BDNF, BCL2, FOS, GRIN2A, IL10, HGF
18	p53 Mediated Apoptosis36	8.4	BCL2, CASP9, CASP3, IL6, IGF1, IL2
19	Cellular Apoptosis Pathway36	8.4	CASP3, CASP9, TNF, TNFRSF1A, NTF3, NRG1
20	PPAR Pathway36	8.4	NGFR, NRG1, IGF1, IL6, TNF, MAPK1
21	ERK Signaling36	8.4	IL2, EPHA3, TGFB2, IL4, IL6, MAPK1
22	MIF Mediated Glucocorticoid Regulation36	8.3	CSF2, HGF, IL1B, IL2, BCL2, LTA
23	DHA Signaling36	8.3	IL2, TGFB1, BDNF, TGFA, BAD, FGF2
24	ILK Signaling36	8.2	NTF3, TNFRSF1A, CASP9, IGF1, MAPK1, MAPK10
25	Pertussis20	8.2	JUN, FOS, CASP3, IL10, MAPK1, IL1B
26	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.2	IL6, IL1B, FOS, JUN, BGLAP, APOE
27	Apoptotic Pathways in Synovial Fibroblasts36	8.2	HGF, FGF2, BDNF, IL6, IL2, NGFR
28	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.2	IGF1, IFNG, TNF, BGLAP, IL6, FOS
29	Immune response IL-1 signaling pathway10	8.1	SERPINE1, EDN1, JUN, FOS, FOSB, IL1B
30	14-3-3 Induced Intracellular Signaling36	8.1	MAPK10, BAD, BDNF, EPHA3, FGF2, JUN
31	JNK Pathway36	8.1	EPHA3, BCL2, TGFB1, NGFR, NRG1, NTF3
32	Leishmaniasis20	8.1	IL10, TGFB2, TGFB1, NFKBIA, NOS2, TNF
33	Immune response_IL-1 signaling pathway41	8.1	FOS, SERPINE1, UBC, JUN, FOSB, IL1B
34	NF-KappaB Family Pathway36	7.9	TGFB2, TGFB1, HGF, TNF, TGFA, BDNF
35	NF-KappaB (p50-p65) Pathway36	7.8	IL2, NFKBIA, LTA, TGFA, TGFB1, TGFB2
36	MIF Regulation of Innate Immune Cells36	7.7	MAPK1, CCL21, TNF, NFKBIA, PF4, LTA
37	Cytokine-cytokine receptor interaction20	7.7	TGFB2, EPO, PRL, CCL21, TNFRSF11B, TNFRSF1A
38	Glucocorticoid Receptor Signaling36	7.6	MAPK1, CCL21, TNFRSF1A, NR3C1, NGFR, MAPK10
39	Tec Kinases Signaling36	7.5	TGFA, BDNF, IL2, IL10, FGF2, FOS
40	p70S6K Signaling36	7.4	BAD, BDNF, IL6, INS, FGF2, HGF
41	Chagas disease (American trypanosomiasis)20	7.3	TGFB2, TGFB1, NFKBIA, NOS2, TNFRSF1A, TNF
42	p38 Signaling36	7.1	CCL21, IL6, IL4, IL2, IL1B, IL10
43	Renin-Angiotensin Pathway36	7.0	JUN, HGF, TGFB2, TGFB1, TGFA, NRG1
44	PAK Pathway36	7.0	MYO1A, BDNF, BCL2, FGF2, IL10, IL1B
45	MAPK Signaling36	6.8	TGFA, NGFR, LTA, TGFB1, FGF2, EPHA3
46	Rho Family GTPases36	6.5	IL1B, TGFB1, TGFB2, CSF2, HGF, EPHA3
47	TGF-Beta Pathway36	6.5	JUN, BCL2, BDNF, NGFR, NRG1, NTF3
48	MAPK Family Pathway36	6.3	HGF, TGFB2, TGFB1, TGFA, IL4, IL2
49	JAK-STAT Pathway36	6.3	EPO, EPHA3, HGF, PRL, IL6, IL4
50	Antioxidant Action of Vitamin-C36	6.1	BCL2, TNF, TNFRSF1A, NTF3, NRG1, PLA2G7

Compounds related to spinal cord injury according to GeneDecks:

(show top 50)    (show all 524)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.9	PDE4A, CNTF, LGALS1, BAD, XIAP, P2RX7
2	citrate32	10.3	PIK3C2A, NAGLU, MYO1A, SDHB, FGF2, F8
3	ivig32	10.2	PIK3C2A, MBP, F8, CRP, PLA2G7, LTA
4	polyethylene glycol32	9.8	SERPINC1, MPO, APOE, MBP, F8, ALPP
5	25-hydroxyvitamin d32	9.8	GC, BGLAP, LEP, ALPP, TNFRSF11B, PTHLH
6	pge132	9.8	PIK3C2A, PDE4A, SERPINE1, FGA, GPT, F5
7	doxorubicin32 34 9 9	12.6	PIK3C2A, CLU, PARP1, BDNF, BAD, XIAP
8	homocysteine32 18	10.4	PIK3C2A, COG2, SERPINC1, SERPINE1, NAGLU, APOE
9	corticosterone32 18	10.3	SERPINA7, BGLAP, BDNF, MPO, FOS, FGF2
10	s-nitroso-n-acetylpenicillamine32	9.3	PARP1, IL1B, IFNG, CASP3, CASP1, CASP9
11	zoledronic acid32	9.2	BGLAP, PARP1, CD36, MMP9, IL2, ALPP
12	celecoxib32 42 34 9 18 9	14.1	REN, BIRC5, PARP1, BCL2, MMP2, MMP9
13	pge232	9.0	PDE4A, REN, CNTF, P2RX7, CD69, ARG1
14	atorvastatin32 34 9 18 9	13.0	PIK3C2A, COG2, MMP2, MMP9, IL10, APOE
15	calcitriol32 42 9 18 9	12.8	REN, GC, CLU, BGLAP, XIAP, JUN
16	heparin32 9 18 9	11.7	PIK3C2A, COG2, SERPINE1, BGLAP, LGALS1, MPO
17	histamine32 18	9.6	PDE4A, CNTF, BGLAP, BDNF, MPO, FGA
18	oxygen32 18	9.6	PIK3C2A, NAGLU, MYO1A, BIRC5, CLU, PARP1
19	arginine32	8.6	PIK3C2A, COG2, PDE4A, REN, CNTF, SERPINC1
20	uric acid32 18	9.5	PIK3C2A, SERPINE1, NAGLU, LGALS1, LEP, MTHFR
21	clozapine32 34 9 9	11.5	LEP, MPO, FOS, IL10, HTR1A, HTR2A
22	forskolin32 42 9 9	11.5	PDE4A, REN, CNP, CNTF, BDNF, UCP1
23	raloxifene32 9 9	10.4	SERPINC1, SERPINA7, SERPINE1, BGLAP, JUN, CD36
24	fibrinogen32	8.3	PIK3C2A, COG2, GC, SERPINC1, SERPINE1, CLU
25	nmda32 42	9.2	PDE4A, BDNF, SDHB, LEP, XIAP, FOS
26	aspirin32 34 18	10.2	COG2, PDE4A, SERPINC1, SERPINA7, SERPINE1, BIRC5
27	triptolide32	8.1	PARP1, BCL2, JUN, IL1B, IL2, IL6
28	matrigel32	8.1	SERPINE1, CLU, BDNF, LGALS1, JUN, CD36
29	chloramphenicol32 9 9	10.0	GC, SERPINC1, SERPINA7, SERPINE1, SDHB, MPO
30	tacrolimus32 34 9 9	10.9	PIN1, REN, SERPINE1, NAGLU, BAD, CD36
31	cisplatin32 34 9 9	10.7	PIK3C2A, NAGLU, BIRC5, CLU, BGLAP, PARP1
32	calcium32 9 18 9	10.6	PIK3C2A, PIN1, COG2, PDE4A, REN, CNTF
33	alpha tocopherol32	7.5	BGLAP, LEP, MTHFR, CD36, MMP9, GSR
34	simvastatin32 34 42 9 18 9	12.5	PIK3C2A, COG2, SERPINE1, BGLAP, MMP9, IL10
35	butyrate32	7.5	BIRC5, CLU, BCL2, LGALS1, LEP, XIAP
36	rantes32	7.5	JUN, MMP9, IL10, IL1B, IL2, IL4
37	adenylate32	7.5	PDE4A, CNP, CNTF, GC, SERPINC1, SERPINE1
38	glutamate32	7.4	CNP, GC, CLU, SDHB, LEP, UCP1
39	lipid32	7.3	PIK3C2A, COG2, PDE4A, CNP, CNTF, GC
40	sb 20358032 42	8.2	BIRC5, BGLAP, PARP1, BCL2, P2RX7, CD36
41	wortmannin32 42	8.0	PIK3C2A, PDE4A, CNTF, BIRC5, BDNF, BCL2
42	thyroxine32 18	7.7	PIK3C2A, COG2, REN, GC, SERPINA7, BGLAP
43	herbimycin a32 42	7.6	JUN, CD36, CD69, MMP2, MMP9, FOS
44	cyclosporin a32 42	7.3	PIK3C2A, PIN1, COG2, PDE4A, NAGLU, BGLAP
45	methotrexate32 34 42 9 9	10.1	PIK3C2A, SERPINE1, NAGLU, BIRC5, LEP, MTHFR
46	estrogen32	5.8	COG2, GC, SERPINC1, SERPINA7, SERPINE1, CLU
47	hydrocortisone32 9 9	7.6	REN, BGLAP, CD36, MMP2, INS, FGF2
48	genistein32 9 18 9	8.3	CNTF, SERPINE1, BIRC5, PARP1, BCL2, P2RX7
49	retinoic acid32 42 18	6.1	PDE4A, CNTF, GC, SERPINE1, BIRC5, CLU
50	dexamethasone32 42 34 9 9	6.8	PDE4A, REN, SERPINC1, SERPINE1, BIRC5, CLU

Cellular components related to spinal cord injury according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	10.2	SST, TGFB1, TGFB2, SOD1, GABBR1, SORT1
2	extracellular matrix	GO:031012	9.9	SERPINE1, SOD1, ZP3, TGFB2, SLPI, DCN
3	cell surface	GO:009986	9.9	TNFRSF1A, TNF, ALPP, GRIN2A, ITGB4, CD36
4	external side of plasma membrane	GO:009897	9.3	CD69, P2RX7, IFNG, CD36, TNF, CD34
5	integral to plasma membrane	GO:005887	9.2	HTR1A, EDNRA, NGFR, PTPRS, PTPRZ1, TNFRSF1A
6	platelet alpha granule lumen	GO:031093	8.8	SERPINE1, CLU, FGA, IGF1, F8, F5
7	plasma membrane	GO:005886	8.3	NTF3, NRN1, RPS27A, NGFR, NFE2L2, NFKBIA
8	cytosol	GO:005829	8.0	MTHFR, XIAP, JUN, ARG1, GSR, IL1B
9	extracellular region	GO:005576	4.5	GC, IL6, APOE, CCL21, IGF1, IFNG
10	extracellular space	GO:005615	3.5	CNTF, FGA, FGF2, IL10, IL1B, IL2

Biological processes related to spinal cord injury according to GeneDecks:

(show all 48)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to wounding	GO:009611	10.7	KLK6, GAP43, TGFB2, GFAP, KLK8, NGFR
2	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.7	NLRP1, RPS27A, PYCARD, CASP1, UBC, BCL2
3	response to axon injury	GO:048678	10.6	EPO, SHH, FGF2, ARG1, LGALS1, SOD1
4	positive regulation of odontogenesis	GO:042482	10.4	EDNRA, CD34, EDN1, TGFB1
5	induction of apoptosis	GO:006917	10.3	MAPK1, TGFB1, APOE, BAD, CASP3, CASP1
6	positive regulation of interleukin-1 beta secretion	GO:050718	10.3	NLRP1, P2RX7, IFNG, CASP1, PYCARD
7	negative regulation of blood coagulation	GO:030195	10.2	APOE, EDN1, THBD, CD34, SERPINE1
8	response to ethanol	GO:045471	10.2	GABBR1, TNFRSF1A, SLC2A4, SOD1, SHH, BGLAP
9	negative regulation of neuron apoptotic process	GO:043524	10.2	GDNF, SOD1, TGFA, NTF3, HMOX1, CNTF
10	response to heat	GO:009408	10.0	SOD1, NOS1, CALCA, IL1B, BCL2, SST
11	positive regulation of cell growth	GO:030307	10.0	IL2, TGFB2, NRG1, F2, INS, BCL2
12	regulation of cell proliferation	GO:042127	10.0	NR3C1, PTGS1, PIN1, SHH, NFKBIA, NOS2
13	positive regulation of vasodilation	GO:045909	10.0	CALCA, NOS1, ADRB2, HMOX1, INS
14	positive regulation of apoptotic process	GO:043065	10.0	IL1B, ALOX12, TNF, PYCARD, TGFB2, SOD1
15	regulation of blood pressure	GO:008217	10.0	REN, HMOX1, LEP, POMC, SOD1, PTGS1
16	synaptic transmission	GO:007268	9.9	PDYN, CNP, SLC1A1, SLC18A3, MAPK1, GAD1
17	response to lipopolysaccharide	GO:032496	9.8	EDN1, LTA, PTGER2, TNFRSF1A, CASP1, MMP9
18	response to estrogen stimulus	GO:043627	9.8	HMOX1, SERPINE1, BGLAP, BCL2, TNFRSF11B, EPO
19	response to radiation	GO:009314	9.7	TGFB2, NR3C1, MMP9, JUN, BCL2, TGFB1
20	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.7	IL1B, TNF, HMOX1, CASP1, CCL21, RPS27A
21	negative regulation of growth of symbiont in host	GO:044130	9.7	IFNG, TNF, CD36, IL10, LTA
22	negative regulation of lipid storage	GO:010888	9.7	TNF, CRP, IL6, NFKBIA
23	female pregnancy	GO:007565	9.6	PRL, CRH, PTHLH, IL4, LEP, BCL2
24	positive regulation of chemokine biosynthetic process	GO:045080	9.5	IL1B, IL4, TNF, IFNG, HMOX1
25	aging	GO:007568	9.5	EPO, JUN, IL1B, HTR2A, CALCA, SERPINA7
26	wound healing	GO:042060	9.5	DCN, TGFB2, TGFA, NRG1, IL1B, FGF2
27	response to cytokine stimulus	GO:034097	9.4	SRF, BCL2, EPHA3, TGFB2, SERPINE1, JUN
28	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.4	NFKBIA, CLU, UBC, INS, IL1B, IL6
29	activation of MAPK activity	GO:000187	9.4	FGF2, P2RX7, RPS27A, IL1B, MAPK10, HGF
30	apoptotic process	GO:006915	9.3	LGALS1, CASP3, CASP1, CASP9, AIMP1, TNF
31	cellular response to lipopolysaccharide	GO:071222	9.3	ARG1, PYCARD, SERPINE1, IFNG, IL10, NOS2
32	inflammatory response	GO:006954	9.2	CALCA, CCL21, AIMP1, TNF, GAL, TNFRSF1A
33	cell-cell signaling	GO:007267	9.1	CCL21, CALCA, SST, POMC, NTF3, PTHLH
34	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.1	IL4, EPO, IL2, IGF1, CSF2
35	innate immune response	GO:045087	9.0	P2RX7, MAPK10, FOS, JUN, PYCARD, UBC
36	platelet degranulation	GO:002576	9.0	F5, HGF, TGFB1, SOD1, TGFB2, CD36
37	positive regulation of mitosis	GO:045840	8.8	EDN1, TNF, INS, IL1B, IGF1, TGFA
38	positive regulation of MAPK cascade	GO:043410	8.7	LEP, P2RX7, INS, IL6, IGF1, NENF
39	positive regulation of protein kinase B signaling cascade	GO:051897	8.7	TGFB1, INS, CCL21, IGF1, ZP3, TNF
40	signal transduction	GO:007165	8.7	IGF1, CASP1, AIMP1, TNFRSF11B, NTF3, NR3C1
41	response to hypoxia	GO:001666	8.5	SHH, NOS2, LTA, LEP, BCL2, EDN1
42	platelet activation	GO:030168	8.4	F2, ALB, SRF, PF4, TGFB1, TGFB2
43	negative regulation of apoptotic process	GO:043066	8.4	CSF2, EPO, SORT1, XIAP, TGFB2, EDNRA
44	blood coagulation	GO:007596	8.2	PLAT, SERPINC1, NOS2, ALB, F2, F5
45	response to drug	GO:042493	8.2	JUN, GAL, IL4, IL10, GRIN2A, ARG1
46	anti-apoptosis	GO:006916	7.7	IL10, HMOX1, TNF, NR3C1, NRG1, RPS27A
47	positive regulation of cell proliferation	GO:008284	7.5	CNTF, BIRC5, HTR2A, F2, IGF1, IL6
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	IL6, IGF1, IFNG, TNF, RPS27A, IL4

Molecular functions related to spinal cord injury according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	copper ion binding	GO:005507	10.2	SOD1, ALB, F5, F8, P2RX7, P2RX2
2	receptor binding	GO:005102	9.3	NTF3, CALCA, F2, FGA, ARTN, ITGB4
3	protease binding	GO:002020	9.1	MBP, INS, SERPINC1, UBC, BCL2, SERPINE1
4	protein homodimerization activity	GO:042803	8.7	HMOX1, AIMP1, PYCARD, SRF, NR3C1, ADRB2
5	hormone activity	GO:005179	8.3	LEP, PTHLH, INS, EPO, POMC, PRL
6	cytokine activity	GO:005125	7.8	TNF, TNFRSF11B, NRG1, LTA, EDN1, TGFB2
7	growth factor activity	GO:008083	6.6	GDNF, IL4, IL2, IL1B, IL10, FGF2
8	protein binding	GO:005515	4.4	KLK3, CRH, NRG1, NR3C1, SPRR1A, SRF