MCID: SPN186
MIFTS: 62

Spinal Cord Injury

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Injury

MalaCards integrated aliases for Spinal Cord Injury:

Name: Spinal Cord Injury 38 51 56
Spinal Cord Injuries 41

Characteristics:

Orphanet epidemiological data:

56
spinal cord injury
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 56 ORPHA90058
UMLS via Orphanet 70 C0037929
ICD10 via Orphanet 34 T09.3

Summaries for Spinal Cord Injury

MedlinePlus : 41 your spinal cord is a bundle of nerves that runs down the middle of your back. it carries signals back and forth between your body and your brain. a spinal cord injury disrupts the signals. spinal cord injuries usually begin with a blow that fractures or dislocates your vertebrae, the bone disks that make up your spine. most injuries don't cut through your spinal cord. instead, they cause damage when pieces of vertebrae tear into cord tissue or press down on the nerve parts that carry signals. spinal cord injuries can be complete or incomplete. with a complete spinal cord injury, the cord can't send signals below the level of the injury. as a result, you are paralyzed below the injury. with an incomplete injury, you have some movement and sensation below the injury. a spinal cord injury is a medical emergency. immediate treatment can reduce long-term effects. treatments may include medicines, braces or traction to stabilize the spine, and surgery. later treatment usually includes medicines and rehabilitation therapy. mobility aids and assistive devices may help you to get around and do some daily tasks. nih: national institute of neurological disorders and stroke

MalaCards based summary : Spinal Cord Injury, also known as spinal cord injuries, is related to detrusor sphincter dyssynergia and dysphagia. An important gene associated with Spinal Cord Injury is RTN4IP1 (Reticulon 4 Interacting Protein 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Pregabalin and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and behavior/neurological

NINDS : 51 A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons -- extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery. Others will result in complete paralysis

Wikipedia : 72 A spinal cord injury (SCI) is damage to the spinal cord that causes changes in its function, either... more...

Related Diseases for Spinal Cord Injury

Diseases related to Spinal Cord Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
id Related Disease Score Top Affiliating Genes
1 detrusor sphincter dyssynergia 29.9 CXCL8 IL6 NOS2 TGFB1 TNF
2 dysphagia 29.7 CXCL8 IL6 TNF
3 pulmonary embolism 29.3 CXCL8 IL6 MMP9 TNF
4 atherosclerosis 29.0 CXCL8 IL6 MMP9 TNF
5 spinal stenosis 21.5 AQP4 ARG1 BDNF CASP3 CXCL8 GDNF
6 central cord syndrome 11.3
7 spasticity 11.3
8 paraplegia 11.2
9 spinal shock 11.2
10 syringomyelia 11.2
11 respiratory failure 11.1
12 spinal cord disease 11.1
13 tethered cord syndrome 11.1
14 tethered spinal cord syndrome 10.8
15 myoclonus 10.8
16 swallowing disorders 10.8
17 central cervical cord syndrome 10.8
18 acute cystitis 10.8
19 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
20 psychologic vaginismus 10.7 BDNF GDNF NOS2
21 upper gum cancer 10.7 GDNF IL6 TNF
22 aortic arch interruption 10.6 IL6 TNF
23 early-onset zonular cataract 10.6 IL6 NOS2 TNF
24 intracranial arteriosclerosis 10.6 IL6 NOS2 TNF
25 levator syndrome 10.6 IL6 NOS2 TNF
26 xanthogranulomatous cholecystitis 10.6 CASP3 MMP9 NOS2
27 vogt-koyanagi-harada disease 10.6 CASP3 IL6 TNF
28 cutaneous leishmaniasis 10.6 IL6 TNF
29 ovarian cystadenocarcinoma 10.6 BDNF CASP3 GFAP
30 cellular schwannoma 10.5 AQP4 GDNF TNF
31 pityriasis rosea 10.5 IL6 MMP9 TNF
32 newborn respiratory distress syndrome 10.5 AQP4 GFAP IL6
33 benign struma ovarii 10.5 IL6 MMP9 NOS2
34 cervicitis 10.5
35 connective tissue cancer 10.5 GDNF GFAP TGFB1
36 tracheal stenosis 10.5 AQP4 IL6 TNF
37 uterine adnexa cancer 10.5 IL6 MMP9 TNF
38 scrotal carcinoma 10.5 IL6 TGFB1 TNF
39 potato nose 10.5 IL6 TGFB1 TNF
40 idiopathic generalized epilepsy 10.5 BDNF CASP3 GFAP
41 rheumatic myocarditis 10.5 IL6 TGFB1 TNF
42 emphysema, congenital lobar 10.4 IL6 MMP9 TNF
43 lung superior sulcus carcinoma 10.4 IL6 NOS2 TNF
44 brain meningioma 10.4 BDNF CASP3 GFAP IL6
45 neurogenic bladder 10.4
46 neuronitis 10.4
47 biemond syndrome 10.4 TGFB1 TNF
48 diamond-blackfan anemia 10.4 MMP9 TGFB1
49 calciphylaxis 10.4 AQP4 IL6 MMP9
50 ileocolitis 10.4 GDNF NOS1 TNF

Graphical network of the top 20 diseases related to Spinal Cord Injury:



Diseases related to Spinal Cord Injury

Symptoms & Phenotypes for Spinal Cord Injury

GenomeRNAi Phenotypes related to Spinal Cord Injury according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 GDNF NGFR NOS2 TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 GDNF NGFR NOS2 TGFB1 TNF

MGI Mouse Phenotypes related to Spinal Cord Injury:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 IL6 KLK8 MMP9 NGFR NOS1 NOS2
2 homeostasis/metabolism MP:0005376 10.36 ARG1 AQP4 NOS1 NOS2 TGFB1 TNF
3 cardiovascular system MP:0005385 10.35 AQP4 CASP3 GDNF GFAP GRIN1 IL6
4 cellular MP:0005384 10.35 BDNF CASP3 GDNF GFAP GRIN1 IL6
5 growth/size/body region MP:0005378 10.35 AQP4 BDNF CASP3 GDNF GFAP GRIN1
6 digestive/alimentary MP:0005381 10.34 AQP4 BDNF CASP3 GDNF GFAP IL6
7 mortality/aging MP:0010768 10.31 KLK8 MMP9 NGFR NOS1 NOS2 TGFB1
8 hematopoietic system MP:0005397 10.3 TNF AQP4 ARG1 CASP3 GDNF GRIN1
9 immune system MP:0005387 10.27 AQP4 ARG1 CASP3 GDNF GFAP IL6
10 nervous system MP:0003631 10.24 GDNF GFAP GRIN1 IL6 KLK8 MMP9
11 endocrine/exocrine gland MP:0005379 10.2 AQP4 BDNF CASP3 GDNF IL6 NOS1
12 muscle MP:0005369 10.1 CASP3 GDNF GFAP IL6 MMP9 NGFR
13 integument MP:0010771 10.08 IL6 MMP9 NGFR NOS2 TGFB1 TNF
14 adipose tissue MP:0005375 10.07 IL6 NGFR NOS1 NOS2 TGFB1 TNF
15 liver/biliary system MP:0005370 10 ARG1 IL6 NGFR NOS1 NOS2 TGFB1
16 renal/urinary system MP:0005367 9.97 AQP4 CASP3 GDNF IL6 MMP9 NGFR
17 reproductive system MP:0005389 9.96 GRIN1 IL6 MMP9 NOS1 NOS2 TGFB1
18 respiratory system MP:0005388 9.9 MMP9 NGFR NOS1 NOS2 TGFB1 TNF
19 vision/eye MP:0005391 9.4 AQP4 BDNF CASP3 GFAP GRIN1 IL6
20 taste/olfaction MP:0005394 9.26 BDNF CASP3 GRIN1 NGFR

Drugs & Therapeutics for Spinal Cord Injury

Drugs for Spinal Cord Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 404)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
2
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
3
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
5
Menthol Approved Phase 4,Phase 2,Phase 3,Phase 1 2216-51-5 16666
6
Amitriptyline Approved Phase 4 50-48-6 2160
7
Perphenazine Approved Phase 4 58-39-9 4748
8
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
9 Piracetam Approved Phase 4 7491-74-9
10
Teriparatide Approved, Investigational Phase 4,Phase 2 52232-67-4 16133850
11
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
12
Zoledronic acid Approved Phase 4,Phase 3,Phase 2 118072-93-8 68740
13
Neostigmine Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 59-99-4 4456
14
Darifenacin Approved, Investigational Phase 4,Phase 2 133099-04-4 444031
15
Oxybutynin Approved, Investigational Phase 4,Phase 3,Phase 2 5633-20-5 4634
16
Trospium Approved Phase 4,Phase 1 10405-02-4, 47608-32-2 5596 5284631
17
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
18
Oxcarbazepine Approved Phase 4 28721-07-5 34312
19
Midodrine Approved Phase 4,Phase 3,Phase 2 133163-28-7, 42794-76-3 4195
20
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
21
Acetaminophen Approved Phase 4 103-90-2 1983
22
Tramadol Approved, Investigational Phase 4,Phase 3 27203-92-5 33741
23
Baclofen Approved Phase 4,Phase 2 1134-47-0 2284
24
Dextromethorphan Approved Phase 4,Phase 2 125-71-3 5360696 5362449
25
Guaifenesin Approved, Vet_approved Phase 4,Phase 2 93-14-1 3516
26
Cycloserine Approved Phase 4 68-41-7 401 6234
27
Trazodone Approved, Investigational Phase 4,Phase 2 19794-93-5 5533
28
Denosumab Approved Phase 4,Phase 2 615258-40-7
29
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
30
Vancomycin Approved Phase 4 1404-90-6 441141 14969
31 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
32
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
33
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
34 Etiracetam Investigational Phase 4 33996-58-6
35
Lactitol Investigational Phase 4 585-86-4 3871
36 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
37 Anti-Anxiety Agents Phase 4,Phase 3,Phase 1,Phase 2
38 Anticonvulsants Phase 4,Phase 3,Phase 2
39 calcium channel blockers Phase 4,Phase 3
40 Calcium, Dietary Phase 4,Phase 3,Phase 2
41 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
44 Tranquilizing Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
45 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3
46 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
47 Vardenafil Dihydrochloride Phase 4,Phase 3
48 Vasodilator Agents Phase 4,Phase 3,Phase 2
49 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
50 Anesthetics Phase 4,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 966)

id Name Status NCT ID Phase Drugs
1 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
2 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
3 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
4 A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury Unknown status NCT00725790 Phase 4 Vardenafil;Placebo
5 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
6 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
7 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
8 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
9 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
10 Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males Completed NCT01067391 Phase 4 tadalafil;placebo
11 Assess Efficacy in Subjects With Traumatic Spinal Cord Injury Completed NCT00667966 Phase 4 Vardenafil (Levitra, BAY 38-9456), 10 mg;Placebo;Vardenafil (Levitra, BAY 38-9456), 20 mg
12 Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients Completed NCT01579500 Phase 4 Botulinum toxin type A;normal saline
13 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed NCT00320281 Phase 4 botulinum toxin A
14 Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury Completed NCT00252954 Phase 4 Levetiracetam
15 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed NCT00826228 Phase 4 teriparatide
16 Project to Improve Symptoms and Mood in People With Spinal Cord Injury Completed NCT00592384 Phase 4 venlafaxine XR;placebo
17 Pressure Ulcer Healing With Microcyn Completed NCT02001558 Phase 4 Microcyn
18 A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction Completed NCT00654082 Phase 4 sildenafil;placebo
19 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
20 Zoledronic Acid Administration in Acute Spinal Cord Injury Completed NCT02042872 Phase 4 Zoledronic acid
21 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed NCT00745095 Phase 4 Neostigmine
22 Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity Completed NCT00800462 Phase 4 Oxybutynin Cl;Trospium Cl;Darifenacin Hydrogen Bromide (HBr)
23 Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis Completed NCT00629642 Phase 4 Solifenacin Succinate;Solifenacin Succinate;Oxybutynin Hydrochloride;Placebo
24 A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition Completed NCT00224029 Phase 4 Oxybutynin transdermal system
25 Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels Completed NCT01896037 Phase 4
26 Symptom Based Treatment of Neuropathic Pain Completed NCT02180880 Phase 4 Pregabalin and Oxcarbazepine
27 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584 Phase 4
28 Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections Completed NCT00318591 Phase 4
29 Body Temperature in Persons With Tetraplegia When Exposed to Cold Completed NCT01822535 Phase 4 Midodrine hydrochloride
30 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed NCT00507546 Phase 4 Ramelteon;Placebo
31 Evaluation of the Nursing C-Spine (Phase IV) Completed NCT01353352 Phase 4
32 C7-T1 Epidural Steroid Injections Versus Targeted Injection for Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4 Triamcinolone 80mg
33 Myobloc Atrophy Study Completed NCT02052024 Phase 4 Botox;MYOBLOC
34 Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression Completed NCT00634426 Phase 4
35 A Study on Health - Related Quality of Life in Patients With Rheumatic Diseases Taking Tramadol 37.5mg/Acetaminophen 325mg Tablets Completed NCT00642837 Phase 4 Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen;Tramadol/acetaminophen
36 Spinal Cord Injury - Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD Recruiting NCT02537899 Phase 4 NeuroAiD
37 Bowel Care and Cardiovascular Function After Spinal Cord Injury Recruiting NCT01567605 Phase 4 Lidocaine lubricant
38 Lower Limb Function After Spinal Cord Injury Recruiting NCT02635893 Phase 4 D-Cycloserine;Placebo
39 Prevention of Bladder Dysfunction in Acute Spinal Cord Injury Recruiting NCT01698138 Phase 4 Onabotulinumtoxin A;Placebo
40 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
41 Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction Recruiting NCT03169582 Phase 4 Avanafil;Sildenafil
42 Effect of Heat Exposure on Cognition in Persons With Tetraplegia Recruiting NCT02488824 Phase 4
43 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
44 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
45 Intrathecal Baclofen (ITB) Delivery Location and Its Effect on Spasticity Recruiting NCT02903823 Phase 4 Baclofen bolus injection
46 Enhancing STDP After Spinal Cord Injury Not yet recruiting NCT02701777 Phase 4 Seromycin;Dextromethorphan;Seromycin Placebo;Dextromethorphan Placebo
47 The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury Not yet recruiting NCT03029442 Phase 4 Denosumab (Prolia)
48 Once Weekly GLP-1 in Persons With Spinal Cord Injury Not yet recruiting NCT03292315 Phase 4 Exenatide 2 MG Injection [Bydureon]
49 Effectiveness of Three Times of Starting Antibiotic Prophylaxis in Patients With Asymptomatic Bacteriuria. Not yet recruiting NCT03269604 Phase 4
50 Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury Terminated NCT02355938 Phase 4 Fidaxomicin 200 mg;Placebo;Vancomycin

Search NIH Clinical Center for Spinal Cord Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Cord Injury cell therapies at LifeMap Discovery.

Genetic Tests for Spinal Cord Injury

Anatomical Context for Spinal Cord Injury

MalaCards organs/tissues related to Spinal Cord Injury:

39
Spinal Cord, Bone, Brain, Testes, Bone Marrow, Colon, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Spinal Cord Injury:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Peripheral Nervous System Peripheral Nerve Domain Myelinating Schwann Cells Potential therapeutic candidate
5 Spinal Cord Spinal Cord White Matter Oligodendrocyte Precursor Cells Potential therapeutic candidate
6 Brain Forebrain White Matter Oligodendrocyte Precursor Cells Potential therapeutic candidate
7 Neural Tube dP4 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
8 Neural Tube Anterior Entopeduncular Area Oligodendrocyte Precursor Cells Potential therapeutic candidate
9 Neural Tube Medial Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
10 Neural Tube dP5 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
11 Neural Tube Caudal Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
12 Neural Tube dP3 Neural Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
13 Neural Tube Lateral Ganglionic Eminence Oligodendrocyte Precursor Cells Potential therapeutic candidate
14 Neural Tube Motor Neural Progenitor Domain Oligodendrocyte Precursor Cells Potential therapeutic candidate
15 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Spinal Cord Injury

Articles related to Spinal Cord Injury:

(show top 50) (show all 1265)
id Title Authors Year
1
Exploratory study to suggest the possibility of MMP-8 and MMP-9 serum levels as early markers for remission after traumatic spinal cord injury. ( 27377304 )
2017
2
Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating Monocytes/Macrophages after Spinal Cord Injury. ( 28082119 )
2017
3
Re: Incidence of Urethral Stricture in Patients with Spinal Cord Injury Treated with Clean Intermittent Self-Catheterization. ( 28905775 )
2017
4
What do spinal cord injury patients think of their improvement? A distribution and anchor based study of the minimal clinically important difference of the Spinal Cord Independence Measure III (SCIM III). ( 28084060 )
2017
5
Spinal cord injury following a mild trauma in homocystinuria-related bone frailty: neurorehabilitation and education on bone health management. ( 28777128 )
2017
6
Chd7 collaborates with Sox2 to regulate activation of oligodendrocyte precursor cells after spinal cord injury. ( 28931573 )
2017
7
Repeated subarachnoid administrations of autologous mesenchymal stromal cells supported in autologous plasma improve quality of life in patients suffering incomplete spinal cord injury. ( 28089079 )
2017
8
Electroacupuncture alleviates the inflammatory response via effects on M1 and M2 macrophages after spinal cord injury. ( 28077367 )
2017
9
Activation of KCNQ channels suppresses spontaneous activity in DRG neurons and reduces chronic pain after spinal cord injury. ( 28073317 )
2017
10
Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength. ( 28929919 )
2017
11
Effect of Concomitant Pain Medications on Response to Pregabalin in Patients with Postherpetic Neuralgia or Spinal Cord Injury-Related Neuropathic Pain. ( 28072797 )
2017
12
Liver Adiposity and Metabolic Profile in Individuals with Chronic Spinal Cord Injury. ( 28948164 )
2017
13
Successful spinal cord stimulation for neuropathic below-level spinal cord injury pain following complete paraplegia: a case report. ( 28808583 )
2017
14
A simple tool to measure spasticity in spinal cord injury subjects. ( 28814047 )
2017
15
Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury. ( 28951789 )
2017
16
Ginsenoside Rg3 Improves Recovery from Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation. ( 28085110 )
2017
17
Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. ( 28479302 )
2017
18
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 28628542 )
2017
19
Elucidation of Gene Expression Patterns in the Brain after Spinal Cord Injury. ( 28933220 )
2017
20
Neuroprotective effects of C-terminal domain of tetanus toxin on rat brain against motorneuron damages after experimental spinal cord injury. ( 28767631 )
2017
21
Lentivirus-mediated silencing of the CTGF gene suppresses the formation of glial scar tissue in a rat model of spinal cord injury. ( 28089819 )
2017
22
Shoulder pain in the Swiss spinal cord injury community: prevalence and associated factors. ( 28084832 )
2017
23
Magnetic resonance imaging tracking and assessing repair function of the bone marrow mesenchymal stem cells transplantation in a rat model of spinal cord injury. ( 28938612 )
2017
24
Suicide and traumatic spinal cord injury-a cohort study. ( 28948966 )
2017
25
Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway. ( 28941865 )
2017
26
Effect of Shikonin on Spinal Cord Injury in Rats Via Regulation of HMGB1/TLR4/NF-kB Signaling Pathway. ( 28934735 )
2017
27
Taking back a little of what you have lost: the meaning of using an Environmental Control System (ECS) for people with high cervical spinal cord injury. ( 28936883 )
2017
28
Identifying the Long-Term Role of Inducible Nitric Oxide Synthase after Contusive Spinal Cord Injury Using a Transgenic Mouse Model. ( 28125047 )
2017
29
Modeling Perceived Exertion during Graded Arm Cycling Exercise in Spinal Cord Injury. ( 28079704 )
2017
30
Anxiety and Depression in Patients with Traumatic Spinal Cord Injury: A Nationwide Population-Based Cohort Study. ( 28081205 )
2017
31
Effective management of spasticity and impacts on weight change and resting energy expenditure in a female with spinal cord injury: a case report. ( 28919982 )
2017
32
Hope, coping and psychosocial adjustment after spinal cord injury. ( 28944084 )
2017
33
Computer-Assessed Preference-Based Quality of Life in Patients with Spinal Cord Injury. ( 28948166 )
2017
34
White matter changes in corticospinal tract associated with improvement in arm and hand functions in incomplete cervical spinal cord injury: pilot case series. ( 28944083 )
2017
35
Twenty Years of a Veterans' Spinal Cord Injury Colorectal Clinic: Flexible Sigmoidoscopy and Multiple Hemorrhoid Ligation. ( 28267007 )
2017
36
Perspectives of individuals with sub-acute spinal cord injury after personalized adapted locomotor training. ( 28084843 )
2017
37
Identification of temporal genes involved in the mechanisms of spinal cord injury. ( 28071686 )
2017
38
Spinal cord injury peer mentorship: Applying self-determination theory to explain quality of life and participation. ( 28947164 )
2017
39
Femoral and Lumbar Fractures During Rehabilitation for a Traumatic Spinal Cord Injury in Osteogenesis Imperfecta: A Case Presentation. ( 28483687 )
2017
40
Hyperphosphatemia in a patient with spinal cord injury who received etidronate for the treatment of heterotopic ossification. ( 28616259 )
2017
41
RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model. ( 28088077 )
2017
42
Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target. ( 28935700 )
2017
43
Post-spinal cord injury astrocyte-mediated functional recovery in rats after intraspinal injection of the recombinant adenoviral vectors Ad5-VEGF and Ad5-ANG. ( 28452633 )
2017
44
Bacterial load of conditioned pressure ulcers is not a predictor for early flap failure in spinal cord injury. ( 28071687 )
2017
45
Suppression of MicroRNA-383 Enhances Therapeutic Potential of Human Bone-Marrow-Derived Mesenchymal Stem Cells in Treating Spinal Cord Injury via GDNF. ( 28365701 )
2017
46
Phase-Dependent deficits during Reach-to-Grasp after Human Spinal Cord Injury. ( 28931614 )
2017
47
Resistance of interleukin-6 to the extracellular inhibitory environment promotes axonal regeneration and functional recovery following spinal cord injury. ( 28075461 )
2017
48
Prognosis Disclosure in Spinal Cord Injury. ( 28086999 )
2017
49
Management of obesity after spinal cord injury: a systematic review. ( 28929907 )
2017
50
Correlating spinal cord injuries with neurogenic bladder pathophysiology. ( 28090756 )
2017

Variations for Spinal Cord Injury

Expression for Spinal Cord Injury

Search GEO for disease gene expression data for Spinal Cord Injury.

Pathways for Spinal Cord Injury

Pathways related to Spinal Cord Injury according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 ARG1 CASP3 CXCL8 GDNF GRIN1 IL6
2
Show member pathways
13.55 BDNF CASP3 CXCL8 GDNF GRIN1 IL6
3
Show member pathways
13.48 BDNF CASP3 CXCL8 GRIN1 IL6 NOS1
4
Show member pathways
13.42 BDNF CASP3 CXCL8 IL6 NGFR TGFB1
5
Show member pathways
13.32 CASP3 CXCL8 GDNF GRIN1 IL6 MMP9
6
Show member pathways
13.28 BDNF CASP3 CXCL8 IL6 NGFR PLA2G2A
7
Show member pathways
12.89 CASP3 IL6 MMP9 NGFR TNF
8
Show member pathways
12.88 CXCL8 IL6 NOS2 TGFB1 TNF
9
Show member pathways
12.85 CASP3 CXCL8 GDNF IL6 TGFB1 TNF
10
Show member pathways
12.71 BDNF IL6 NGFR TGFB1 TNF
11 12.67 CASP3 CXCL8 IL6 MMP9 NOS2 TGFB1
12
Show member pathways
12.48 CASP3 CXCL8 NOS1 NOS2
13
Show member pathways
12.34 CASP3 CXCL8 IL6 MMP9 TNF
14 12.31 CASP3 MMP9 TGFB1 TNF
15
Show member pathways
12.28 CXCL8 IL6 NOS2 TNF
16
Show member pathways
12.26 CASP3 NOS2 TGFB1 TNF
17 12.24 CXCL8 IL6 MMP9 NGFR
18 12.23 CASP3 IL6 NOS2 TGFB1 TNF
19
Show member pathways
12.19 CXCL8 IL6 NOS2 TNF
20 12.15 CASP3 IL6 MMP9 NOS2 TGFB1 TNF
21 12.13 BDNF CASP3 GRIN1 NGFR
22
Show member pathways
12 CASP3 GRIN1 NOS1 TNF
23 11.96 CASP3 IL6 MMP9 TNF
24 11.91 AQP4 BDNF CASP3 CXCL8 GRIN1 IL6
25 11.89 IL6 NGFR TGFB1
26 11.89 CASP3 CXCL8 IL6 TGFB1 TNF
27 11.87 CASP3 CXCL8 TGFB1
28
Show member pathways
11.87 CXCL8 IL6 TGFB1
29 11.87 CXCL8 IL6 TGFB1 TNF
30 11.83 CXCL8 IL6 NOS2
31
Show member pathways
11.83 BDNF NGFR TNF
32 11.8 BDNF GDNF GFAP
33 11.79 CXCL8 IL6 MMP9 NOS2 TGFB1 TNF
34
Show member pathways
11.77 CASP3 CXCL8 TNF
35 11.77 IL6 TGFB1 TNF
36 11.76 CASP3 CXCL8 IL6 NOS2 TNF
37 11.72 IL6 NOS2 TGFB1 TNF
38 11.7 CASP3 MMP9 NOS2
39
Show member pathways
11.7 BDNF CASP3 NGFR
40 11.68 CASP3 CXCL8 IL6 MMP9
41 11.63 CASP3 MMP9 PLA2G2A
42 11.63 AQP4 ARG1 BDNF CASP3 CXCL8 GDNF
43
Show member pathways
11.62 ARG1 NOS1 NOS2
44 11.6 CXCL8 IL6 MMP9 TGFB1 TNF
45 11.58 ARG1 CXCL8 IL6 NOS2
46 11.57 CASP3 CXCL8 IL6 TNF
47
Show member pathways
11.57 CXCL8 IL6 MMP9 NOS2 TNF
48 11.55 CXCL8 IL6 TNF
49 11.53 IL6 MMP9 TNF
50 11.53 KLK8 NOS2 TNF

GO Terms for Spinal Cord Injury

Cellular components related to Spinal Cord Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ARG1 CXCL8 IL6 KLK8 MMP9 PLA2G2A
2 extracellular region GO:0005576 9.36 ARG1 BDNF CXCL8 GDNF IL6 KLK8

Biological processes related to Spinal Cord Injury according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.94 GDNF GRIN1 TGFB1 TNF
2 inflammatory response GO:0006954 9.91 CXCL8 IL6 NGFR TGFB1 TNF
3 regulation of cell proliferation GO:0042127 9.89 IL6 NOS2 TGFB1 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 IL6 PLA2G2A TGFB1 TNF
5 wound healing GO:0042060 9.83 CASP3 IL6 TGFB1
6 defense response to Gram-positive bacterium GO:0050830 9.83 IL6 PLA2G2A TNF
7 response to organic substance GO:0010033 9.82 CASP3 TGFB1 TNF
8 positive regulation of protein kinase B signaling GO:0051897 9.82 IL6 TGFB1 TNF
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.8 CASP3 NGFR TNF
10 response to hypoxia GO:0001666 9.8 CASP3 NOS1 NOS2 TGFB1
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 IL6 TGFB1 TNF
12 cellular response to organic cyclic compound GO:0071407 9.77 CASP3 TGFB1 TNF
13 apoptotic signaling pathway GO:0097190 9.76 CASP3 NGFR TNF
14 cell redox homeostasis GO:0045454 9.75 IL6 NOS1 NOS2
15 response to glucocorticoid GO:0051384 9.73 CASP3 IL6 TNF
16 response to lipopolysaccharide GO:0032496 9.72 ARG1 CASP3 IL6 NGFR NOS2
17 negative regulation of fat cell differentiation GO:0045599 9.65 IL6 TGFB1 TNF
18 cellular response to lipopolysaccharide GO:0071222 9.65 ARG1 CXCL8 IL6 NOS2 TNF
19 nitric oxide biosynthetic process GO:0006809 9.63 NOS1 NOS2
20 positive regulation of guanylate cyclase activity GO:0031284 9.61 NOS1 NOS2
21 cellular response to dexamethasone stimulus GO:0071549 9.58 ARG1 IL6 TGFB1
22 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
23 positive regulation of receptor binding GO:1900122 9.54 BDNF MMP9
24 response to amino acid GO:0043200 9.54 ARG1 CASP3 IL6
25 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.52 IL6 TNF
26 positive regulation of apoptotic process GO:0043065 9.5 CASP3 GRIN1 IL6 MMP9 NGFR TGFB1
27 peptidyl-cysteine S-nitrosylation GO:0018119 9.46 NOS1 NOS2
28 positive regulation of mononuclear cell migration GO:0071677 9.43 TGFB1 TNF
29 arginine catabolic process GO:0006527 9.33 ARG1 NOS1 NOS2
30 negative regulation of activated T cell proliferation GO:0046007 9.3 CASP3
31 response to wounding GO:0009611 9.02 ARG1 CASP3 IL6 KLK8 TGFB1
32 negative regulation of apoptotic process GO:0043066 10.03 CASP3 GDNF IL6 MMP9 NGFR

Molecular functions related to Spinal Cord Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 CXCL8 IL6 TGFB1 TNF
2 calmodulin binding GO:0005516 9.62 GRIN1 NGFR NOS1 NOS2
3 growth factor activity GO:0008083 9.46 BDNF GDNF IL6 TGFB1
4 FMN binding GO:0010181 9.43 NOS1 NOS2
5 arginine binding GO:0034618 9.37 NOS1 NOS2
6 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS1 NOS2
7 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS2
8 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS2

Sources for Spinal Cord Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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