MCID: SPN027
MIFTS: 53

Spinal Stenosis malady

Summaries for Spinal Stenosis

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and radiculopathy. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are RXR and RAR heterodimerization with other nuclear receptor and Endochondral Ossification. The compounds calcium gluconate and etidronic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and spinal cord, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Disease Ontology:8 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia:64 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Aliases & Classifications for Spinal Stenosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

spinal stenosis 8 10 45 34 31 61
spinal stenosis of lumbar region 8 61
spinal stenosis in cervical region 61
cervical spinal stenosis 8
lumbar spinal stenosis 8


Related Diseases for Spinal Stenosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis30.9BMP7, FTH1, TSSK4
2radiculopathy30.5HSF4, COL6A1, KLK8
3osteoarthritis30.5COL11A2, COL9A1, COL9A2, COL9A3, CALCA, BMP7
4renal osteodystrophy30.2VDR, BMP7, CALCA
5spondylosis30.1COL6A1, TSSK4
6osteoporosis29.9CALCA, BMP7, VDR, TGFB1
7back pain10.6
8intermittent claudication10.4
9lumbar disc herniation10.4
10achondroplasia10.4
11cauda equina syndrome10.4
12chronic pain10.3
13quadriplegia10.3
14pseudogout10.2
15osteoporotic fracture10.1
16diffuse idiopathic skeletal hyperostosis10.1
17syringomyelia10.1
18central cord syndrome10.1
19foot drop10.1
20spinal cord injury10.1
21short stature10.0INS
22myopia 610.0COL11A2
23nephrosclerosis10.0TGFB1
24spondylitis10.0ACAN
25hypothyroidism10.0INS
26hypoparathyroidism10.0CALCA
27hemochromatosis10.0FTH1
28myelodysplastic syndromes10.0VDR
29cataract10.0HSF4
30cleft palate10.0COL11A2
31thalassemia10.0FTH1
32intracranial hypotension10.0HSF4
33hyperparathyroidism10.0VDR, CALCA
34scheuermann's disease10.0COL9A3
35diabetic retinopathy10.0INS
36duodenal ulcer10.0INS
37myopathy10.0COL6A1, INS
38spinal cord disease10.0HSF4, COL6A1
39diastrophic dysplasia10.0COL9A3, COL9A2
40hypogonadism10.0CALCA, INS
41parathyroid adenoma10.0VDR, CALCA
42migraine10.0CALCA
43degenerative disc disease10.0COL9A3, COL9A2
44nephrolithiasis10.0VDR
45graves' disease10.0VDR
46secondary hyperparathyroidism of renal origin10.0CALCA, BMP7, VDR
47thyroid cancer, anaplastic10.0TGFB1, BMP7, CALCA
48proteinuria10.0BMP7, INS, TGFB1
49ureteral disease10.0BMP7, TGFB1
50lumbar disc disease10.0VDR, COL9A3, COL9A2

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to spinal stenosis

Clinical Features for Spinal Stenosis

Drugs & Therapeutics for Spinal Stenosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spinal Stenosis

Drug clinical trials:

Search ClinicalTrials for Spinal Stenosis

Search NIH Clinical Center for Spinal Stenosis

Search CenterWatch for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spinal Stenosis

Anatomical Context for Spinal Stenosis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Spinal Stenosis:

33
Skin, Spinal cord, Brain, Lung, Whole blood, Cortex, Skeletal muscle, Dorsal root ganglion, Pituitary

FMA organs/tissues related to Spinal Stenosis:

14
Spinal cord

Animal Models for Spinal Stenosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Spinal Stenosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6ACAN, BMP7, COL9A1
2MP:00053909.4COL9A1, CALCA, BMP7, VDR, INS, ACAN

Publications for Spinal Stenosis

Sources:
51PubMed
See all sources

Articles related to Spinal Stenosis:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
Spinal stenosis. (24365318)
2014
2
The 2-Year Cost-Effectiveness of 3 options to Treat Lumbar Spinal Stenosis Patients. (24393198)
2014
3
Lumbar spinal stenosis impairs function following total knee arthroplasty. (23288774)
2013
4
Unilateral approach for bilateral decompression of lumbar spinal stenosis: a minimal invasive surgery. (24304987)
2013
5
Limaprost alfadex and nonsteroidal anti-inflammatory drugs for sciatica due to lumbar spinal stenosis. (23090093)
2013
6
Associations between physical therapy and long-term outcomes for individuals with lumbar spinal stenosis in the SPORT study. (24373681)
2013
7
Decompression and Coflex interlaminar stabilization compared with decompression and instrumented spinal fusion for spinal stenosis and low-grade degenerative spondylolisthesis: two-year results from the prospective, randomized, multicenter, Food and Drug Administration Investigational Device Exemption trial. (23680830)
2013
8
Anatomic radiological variations in developmental lumbar spinal stenosis: a prospective, control-matched comparative analysis. (24314904)
2013
9
The professor position and the single-stance flexion test may clarify the effect of lumbar spinal stenosis or pseudostenosis on lower-extremity symptoms. (23536509)
2013
10
Clinical Effectiveness of Percutaneous Adhesiolysis and Predictive Factors of Treatment Efficacy in Patients with Lumbosacral Spinal Stenosis. (23802996)
2013
11
The effects of lumbo-pelvic postural taping on gait parameters in patients with lumbar spinal stenosis. (24168812)
2013
12
Evaluation of prognostic predictors of percutaneous adhesiolysis using a Racz catheter for post lumbar surgery syndrome or spinal stenosis. (24077203)
2013
13
Neurological deterioration due to missed thoracic spinal stenosis after decompressive lumbar surgery: A report of six cases of tandem thoracic and lumbar spinal stenosis. (24078537)
2013
14
Lumbar vertebral hemangioma mimicking lateral spinal canal stenosis: Case report and review of literature. (24090267)
2013
15
Atypical guillain-barrAc syndrome misdiagnosed as lumbar spinal stenosis. (23826482)
2013
16
Changes in objectively measured physical activity (performance) after epidural steroid injection for lumbar spinal stenosis. (22659537)
2012
17
Study protocol- Lumbar Epidural steroid injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults. (22458343)
2012
18
Regarding: long-term results of percutaneous lumbar decompression mild for spinal stenosis. (22390527)
2012
19
Difficulty of diagnosing the origin of lower leg pain in patients with both lumbar spinal stenosis and hip joint osteoarthritis. (22588380)
2012
20
Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study. (22020607)
2012
21
Correlation between disability and MRI findings in lumbar spinal stenosis: a prospective study of 109 patients operated on by decompression. (21434811)
2011
22
Uncertainties in the diagnosis of lumbar spinal stenosis. (22095990)
2011
23
mild(Ar) Lumbar Decompression for the Treatment of Lumbar Spinal Stenosis. (24059721)
2011
24
Rationale, design and clinical performance of the SuperionAr Interspinous Spacer: a minimally invasive implant for treatment of lumbar spinal stenosis. (21728727)
2011
25
Comparative effectiveness evidence from the spine patient outcomes research trial: surgical versus nonoperative care for spinal stenosis, degenerative spondylolisthesis, and intervertebral disc herniation. (22048651)
2011
26
Postoperative rehabilitation does not improve functional outcome in lumbar spinal stenosis: a prospective study with 2-year postoperative follow-up. (21523459)
2011
27
Intraoperative three-dimensional imaging in selective decompression for lumbar spinal stenosis: a useful tool in theory but also in everyday practice? (22091370)
2011
28
A haplotype at the COL9A2 gene locus contributes to the genetic risk for lumbar spinal stenosis in the Korean population. (21228751)
2011
29
Three-step treadmill test and McKenzie mechanical diagnosis and therapy to establish directional preference in a patient with lumbar spinal stenosis: a case report. (22294852)
2011
30
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications. (20861423)
2010
31
Diabetes mellitus as a risk factor for the development of lumbar spinal stenosis. (20450123)
2010
32
Fluoroscopically guided caudal epidural steroid injection for management of degenerative lumbar spinal stenosis: short-term and long-term results. (20033148)
2010
33
Diagnostic challenge: bilateral infected lumbar facet cysts--a rare cause of acute lumbar spinal stenosis and back pain. (20205727)
2010
34
Treatment options for lumbar spinal stenosis. (20594015)
2010
35
Transforaminal epidural steroid injection via a preganglionic approach for lumbar spinal stenosis and lumbar discogenic pain with radiculopathy. (20508344)
2010
36
Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis. (19190056)
2009
37
The relationship between spinal stenosis and neurological outcome in traumatic cervical spine injury: an analysis using Pavlov's ratio, spinal cord area, and spinal canal area. (19884992)
2009
38
Postoperative outcome after modified unilateral-approach microendoscopic midline decompression for degenerative spinal stenosis. (19441985)
2009
39
Comparison of effectiveness according to different approaches of epidural steroid injection in lumbosacral herniated disk and spinal stenosis. (20023335)
2009
40
A prospective, masked 18-month minimum follow-up on neurophysiologic changes in persons with spinal stenosis, low back pain, and no symptoms. (19627886)
2009
41
Treating lumbar spinal stenosis. Medications and physical therapy can help--and so can surgery. (18700289)
2008
42
Gait analysis does not correlate with clinical and MR imaging parameters in patients with symptomatic lumbar spinal stenosis. (18570636)
2008
43
Microsurgical bilateral decompression via a unilateral approach for lumbar spinal canal stenosis including degenerative spondylolisthesis. (19035747)
2008
44
High failure rate of the interspinous distraction device (X-Stop) for the treatment of lumbar spinal stenosis caused by degenerative spondylolisthesis. (17846801)
2008
45
Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. (16865379)
2007
46
Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. (14644861)
2003
47
Metabolic changes in the cerebrospinal fluid of patients with lumbar disc herniation or spinal stenosis. (12210836)
2002
48
Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. (11679833)
2001
49
Thoracic spinal stenosis associated with renal osteodystrophy. Diagnosis based on magnetic resonance imaging and computed tomography. (8211372)
1993
50
Sudden quadriplegia after a minor trauma. The role of preexisting spinal stenosis. (3966211)
1985

Genetic Variations for Spinal Stenosis

Expression for genes affiliated with Spinal Stenosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for genes affiliated with Spinal Stenosis

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 52QIAGEN
See all sources

Pathways related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TGFB1, VDR
210.0BMP7, ACAN, TGFB1
3
Hide members
10.0COL9A1, COL6A1, COL11A2
49.9TGFB1, ACAN, KLK8
5
Hide members
9.8COL6A1, COL9A1, COL9A2, COL9A3
6
Hide members
9.8COL6A1, COL9A1, COL9A2, COL9A3
7
Hide members
9.7COL9A3, COL9A2, COL9A1, COL6A1, COL11A2
8
Hide members
9.7COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
99.7COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
10
Hide members
9.4COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, BMP7
11
Hide members
9.4COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, BMP7
12
Hide members
9.1ACAN, KLK8, COL11A2, COL6A1, COL9A1, COL9A2

Compounds for genes affiliated with Spinal Stenosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1calcium gluconate4510.5INS, CALCA
2etidronic acid45 50 1112.4CALCA, VDR
3safranin o4510.4BMP7, ACAN
4thiazide4510.4INS, VDR, CALCA
5dmsa4510.4VDR, CALCA
6alfacalcidol45 60 1112.3CALCA, VDR
7alginate4510.3BMP7, ACAN, TGFB1
824,25-dihydroxyvitamin d34510.3CALCA, VDR
9thyroxine45 2411.2TGFB1, INS, VDR, CALCA
10calcitriol45 60 11 2413.2TGFB1, VDR, BMP7, CALCA
11i-app4510.1CALCA, INS
121,25 dihydroxy vitamin d34510.1TGFB1, VDR, CALCA
13vitamin d4510.0CALCA, BMP7, VDR, ACAN, TGFB1
14pge24510.0CALCA, BMP7, VDR, ACAN, TGFB1
15creatinine459.9CALCA, BMP7, VDR, INS, TGFB1
16pramlintide45 1110.9INS, CALCA
17ascorbic acid45 2410.8ACAN, FTH1, VDR, BMP7

GO Terms for genes affiliated with Spinal Stenosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0TGFB1, ACAN, INS
2collagen type IXGO:0055949.6COL9A1, COL9A2, COL9A3
3endoplasmic reticulum lumenGO:0057889.2INS, COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
4extracellular regionGO:0055768.6COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, CALCA

Biological processes related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ossificationGO:03027910.2TGFB1, CALCA
2positive regulation of cellular protein metabolic processGO:03227010.1TGFB1, INS
3positive regulation of peptidyl-threonine phosphorylationGO:0108009.9TGFB1, BMP7
4collagen catabolic processGO:0305749.8COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
5extracellular matrix disassemblyGO:0226179.8COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
6skeletal system developmentGO:0015019.8ACAN, VDR, BMP7, COL9A2, COL11A2
7axon guidanceGO:0074119.7COL6A1, COL9A1, COL9A2, COL9A3, BMP7
8extracellular matrix organizationGO:0301989.4TGFB1, COL11A2, COL6A1, COL9A1, COL9A2, COL9A3

Molecular functions related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.8COL9A3, COL9A2, COL9A1, COL11A2

Products for genes affiliated with Spinal Stenosis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Spinal Stenosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet