Spinal Stenosis malady

MedlinePlus: Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing can occur at the center of your spine, in the canals branching off your spine and/or between the vertebrae, the bones of the spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back, numbness, weakness or pain in your arms or legs, and foot problems. treatments include medications, physical therapy, braces and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to secondary hyperparathyroidism of renal origin and spondylosis. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Protein digestion and absorption and FAK1 Signaling. The compounds glycosaminoglycan and calcium gluconate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, spinal cord and skin, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Disease Ontology: A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.⁶

Wikipedia: Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the...⁴⁴ more...

Aliases & Descriptions:

spinal stenosis 6 8 32 23 43 spinal stenosis of lumbar region 6 43 spinal stenosis in cervical region 43

cervical spinal stenosis 6 lumbar spinal stenosis 6

Diseases related to spinal stenosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 184)

id	Related Disease	Score	Top Affiliating Genes
1	secondary hyperparathyroidism of renal origin	13.5	VDR, BMP7, CALCA
2	spondylosis	13.5	VDR, IFIT1, COL6A1
3	spinal cord disease	13.5	IFIT1, HSF4, COL6A1
4	degenerative disc disease	13.5	COL9A2, COL9A3
5	intracranial hypotension	13.5	HSF4, KLK8
6	craniometaphyseal dysplasia	13.5	ARSD, CALCA
7	lipoid proteinosis	13.5	INS, COL9A1
8	rickets	13.5	VDR, INS, CALCA
9	thyroid cancer, anaplastic	13.5	BMP7, CALCA, TGFB1
10	renal osteodystrophy	13.5	VDR, BMP7, CALCA
11	hip dysplasia	13.5	VDR, TGFB1
12	osteoporosis, postmenopausal	13.4	VDR, CALCA, TGFB1
13	lumbar disc disease	13.4	VDR, COL9A2, COL9A3
14	nephrosclerosis	13.4	BMP7, INS, CALCA, TGFB1
15	exostosis	13.4	IFIT1, ACAN, TGFB1
16	ossification of posterior longitudinal ligament of spine	13.4	VDR, COL11A2, COL6A1, TGFB1
17	stickler syndrome, type 2	13.4	COL11A2, COL11A1
18	diastrophic dysplasia	13.4	COL9A2, COL9A3, TGFB1
19	wagner syndrome	13.3	COL11A2, COL11A1
20	marshall syndrome	13.3	COL11A2, COL11A1
21	hypoparathyroidism	13.3	VDR, INS, CALCA
22	multiple epiphyseal dysplasia, dominant	13.3	COL9A2, COL9A3, COL9A1
23	secondary syphilis	13.2	VDR, BMP7, CALCA, SPARC
24	was-related disorders	13.2	VDR, INS, CALCA, COL6A1, TGFB1
25	iron overload	13.2	VDR, FTH1, INS, CALCA
26	lumbar disc degeneration	13.1	VDR, MMP3, COL9A2
27	hemochromatosis	13.1	FTH1, INS, CALCA, TGFB1
28	macroglossia	13.1	COL11A2, COL11A1, COL9A1
29	parathyroid adenoma	13.1	VDR, CALCA, TGFB1
30	hyperparathyroidism	13.1	VDR, BMP7, INS, CALCA, TGFB1
31	periostitis	13.0	BMP7, MMP3, TGFB1
32	lung giant cell carcinoma	13.0	TIMP1, TGFB1
33	pseudoachondroplasia	13.0	COL9A2, COL9A3, COL9A1, ACAN
34	acrodysostosis	13.0	INS, PDE4D
35	proteinuria	13.0	VDR, BMP7, FTH1, INS, TGFB1
36	hypothyroidism	13.0	VDR, FTH1, INS, CALCA, TGFB1
37	pierre robin sequence	12.9	COL11A2, COL9A2, COL11A1, COL9A1
38	stickler syndrome	12.9	COL11A2, COL9A2, COL11A1, COL9A1
39	hypersensitivity reaction type ii disease	12.9	VDR, FTH1, INS, TGFB1
40	ureteral obstruction	12.9	BMP7, TIMP1, TGFB1
41	chronic kidney failure	12.8	VDR, BMP7, MMP3, INS, TGFB1
42	uremia	12.8	VDR, INS, CALCA, TIMP1
43	arterial calcification	12.8	VDR, MMP3, INS, SPARC
44	sorsby fundus dystrophy	12.7	MMP3, TIMP1
45	neurocirculatory asthenia	12.7	MMP3, COL11A1, TGFB1
46	pneumoconiosis	12.7	FTH1, MMP3, TGFB1
47	migraine without aura	12.7	VDR, MMP3, INS, CALCA, TGFB1
48	status asthmaticus	12.7	MMP3, TIMP1, TGFB1
49	celiac disease	12.7	VDR, MMP3, INS, CALCA, TGFB1
50	chondrodysplasia	12.7	ARSD, COL11A1, COL9A1, ACAN

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to spinal stenosis:

²²

FMA organs/tissues related to spinal stenosis:

¹¹

MGI Mouse Phenotypes related to spinal stenosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	8.3	ACAN, COL9A1, COL11A1, COL11A2, CALCA, BMP7
2	skeleton phenotype	MP:0005390	7.3	ACAN, COL9A1, COL11A1, COL11A2, SPARC, CALCA
3	immune system phenotype	MP:0005387	INF	VDR, TGFB1, TIMP2, TIMP1, ACAN,
4	homeostasis/metabolism phenotype	MP:0005376	INF	TIMP2, TIMP1, ACAN, KLK8, , COL9A1

Articles related to spinal stenosis:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	A haplotype at the COL9A2 gene locus contributes to t he genetic risk for lumbar spinal stenosis in the Korean population. (21228751)	Hyun S.J.... Jeon S.R.	2011	COL9A2
2	Re: Coronado-Zarco R, Cruz-Medina E, Arellano-HernA!nd ez A, et al. Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis. A systemic review. Spine 2009;34;22:E 818-27. (20160619)	Gadoth N.	2010	CALCA
3	The efficacy of physical therapy and physical therapy plus calcitonin in the treatment of lumbar spinal stenosis. (19881973)	Sahin F.... Kuran B.	2009	CALCA
4	Effectiveness of calcitonin in intermittent claudicat ion treatment of patients with lumbar spinal stenosis: a systematic review. (19829246)	Coronado-Zarco R.... LeA^n-HernA!ndez S.R.	2009	CALCA
5	An open study of pamidronate in the treatment of refr actory degenerative lumbar spinal stenosis. (19219479)	Feld J.... Rozenbaum M.	2009	CALCA
6	Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. (16865379)	Tafazal S.I.... Sell P.	2007	CALCA
7	Serum Levels of TGF-beta1, TIMP-1 and TIMP-2 in Patie nts with Lumbar Spinal Stenosis and Disc Herniation. (20411146)	Kim H.J.... Chang H.	2007	TGFB1, TIMP2, TIMP1
8	Outcomes of decompression surgery for lumbar spinal stenosis in elderly diabetic patients. (14614597)	Arinzon Z.... Gepstein R.	2004	INS
9	Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. (14644861)	Noponen-Hietala N.... Ala-Kokko L.	2003	MMP3, VDR, COL9A1
10	Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. (11679833)	Park J.B.... Lee J.K.	2001	TGFB1
11	Characterization of cultured human ligamentum flavum cells in lumbar spine stenosis. (11347704)	Specchia N.... Toesca A.	2001	SPARC
12	Calcitonin treatment in lumbar spinal stenosis: a randomized, placebo-controlled, double-blind, cross-over study with one-year follow-up. (1596776)	Eskola A.... SlAotis P.	1992	CALCA

Genes related to spinal stenosis according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	CALCA	calcitonin-related polypeptide alpha	11.1	Publications
2	BMP7	bone morphogenetic protein 7	11.1
3	HSF4	heat shock transcription factor 4	11.0
4	IFIT1	interferon-induced protein with tetratricopeptide repeats 1	11.0
5	KLK8	kallikrein-related peptidase 8	11.0
6	COL6A1	collagen, type VI, alpha 1	11.0
7	COL11A2	collagen, type XI, alpha 2	11.0	Publications
8	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
9	INS	insulin	11.0	Publications
10	TGFB1	transforming growth factor, beta 1	11.0	Publications
11	TSSK4	testis-specific serine kinase 4	11.0	Disorders
12	COL9A2	collagen, type IX, alpha 2	11.0	Publications
13	VAT1	vesicle amine transport protein 1 homolog (T. californica)	11.0
14	CCDC34	coiled-coil domain containing 34	11.0
15	DCD	dermcidin	11.0
16	OR10R2	olfactory receptor, family 10, subfamily R, member 2	11.0
17	COL9A3	collagen, type IX, alpha 3	11.0	Publications
18	ARSD	arylsulfatase D	11.0
19	ELP2	elongator acetyltransferase complex subunit 2	11.0
20	FTH1	ferritin, heavy polypeptide 1	11.0
21	LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	11.0
22	COL9A1	collagen, type IX, alpha 1	11.0	Publications
23	ACAN	aggrecan	11.0	Publications
24	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
25	PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	11.0	Disorders
26	COL11A1	collagen, type XI, alpha 1	11.0	Publications
27	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
28	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
29	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications

Pathways related to spinal stenosis according to GeneDecks:

(show all 30)

id	Pathway	Score	Top Affiliating Genes
1	Protein digestion and absorption20	9.2	COL9A1, COL6A1, COL11A1, COL9A3, COL9A2, COL11A2
2	FAK1 Signaling36	9.1	COL9A1, COL6A1, COL11A1, COL9A3, COL9A2, COL11A2
3	Integrin Pathway36	9.1	COL9A1, COL6A1, COL11A1, COL9A3, COL9A2, COL11A2
4	GnRH Signaling36	9.1	COL9A1, COL6A1, COL11A1, COL9A3, COL9A2, COL11A2
5	PTEN Pathway36	9.1	BMP7, COL9A1, COL6A1, COL11A1, COL9A3, COL9A2
6	Intrinsic Prothrombin Activation Pathway36	9.1	KLK8, COL9A1, COL6A1, COL11A1, COL9A3, COL9A2
7	Blood Coagulation Cascade36	9.1	KLK8, COL9A1, COL6A1, COL11A1, COL9A3, COL9A2
8	Inhibition of Angiogenesis by TSP136	9.0	TGFB1, COL9A1, COL6A1, COL11A1, COL9A3, COL9A2
9	mTOR Pathway36	8.9	TGFB1, TIMP2, TIMP1, INS, BMP7
10	eIF2 Pathway36	8.8	BMP7, INS, TIMP1, TIMP2, TGFB1
11	p70S6K Signaling36	8.8	TGFB1, TIMP2, TIMP1, INS, BMP7
12	Cell adhesion Cell-matrix glycoconjugates10	8.8	TIMP2, ACAN, MMP3
13	Apoptotic Pathways in Synovial Fibroblasts36	8.8	TGFB1, TIMP2, TIMP1, BMP7
14	Telomerase Components in Cell Signaling36	8.8	BMP7, TIMP1, TIMP2, TGFB1
15	Activation of Matrix Metalloproteinases38	8.8	MMP3, TIMP1, TIMP2
16	Cell adhesion_Cell-matrix glycoconjugates41	8.7	MMP3, ACAN, TIMP2
17	p53 Mediated Apoptosis36	8.7	TGFB1, TIMP2, TIMP1, BMP7
18	Inhibition of Matrix Metalloproteinases36	8.7	MMP3, TIMP1, TIMP2
19	UPA-UPAR Pathway36	8.5	COL9A1, COL6A1, COL11A1, COL9A3, COL9A2, COL11A2
20	Transendothelial Migration of Leukocytes36	8.5	COL9A1, COL6A1, COL11A1, COL9A3, COL9A2, COL11A2
21	Glioma Invasiveness36	8.5	TGFB1, TIMP2, TIMP1, BMP7
22	Cell adhesion_ECM remodeling41	8.4	TIMP2, TIMP1, SPARC, MMP3
23	Cell adhesion ECM remodeling10	8.4	TIMP2, TIMP1, SPARC, MMP3
24	Pancreatic Adenocarcinoma36	8.3	TGFB1, TIMP2, TIMP1, MMP3, BMP7
25	Phospholipase-C Pathway36	7.5	TGFB1, TIMP2, TIMP1, COL9A1, COL6A1, COL11A1
26	ILK Signaling36	7.5	COL9A1, TIMP1, TIMP2, TGFB1, COL6A1, COL11A1
27	MAPK Signaling36	7.5	COL9A1, TIMP1, TIMP2, TGFB1, COL6A1, COL11A1
28	Rho Family GTPases36	7.5	COL9A1, TIMP1, TIMP2, TGFB1, COL6A1, COL11A1
29	ERK Signaling36	7.5	TGFB1, TIMP2, TIMP1, COL9A1, COL6A1, COL11A1
30	Molecular Mechanisms of Cancer36	7.5	TGFB1, TIMP2, TIMP1, COL9A1, COL6A1, COL11A1

Compounds related to spinal stenosis according to GeneDecks:

(show all 45)

id	Compound	Score	Top Affiliating Genes
1	glycosaminoglycan32	10.5	ACAN
2	calcium gluconate32	10.5	CALCA, INS
3	pirfenidone32	10.4	TGFB1, BMP7
4	thiazide32	10.3	VDR, INS, CALCA
5	rhein32	9.9	TIMP1, TGFB1
6	deoxypyridinoline32	9.9	VDR, MMP3, CALCA
7	thyroxine32 18	10.8	TGFB1, CALCA, INS, VDR
8	safranin o32	9.8	BMP7, MMP3, ACAN
9	troglitazone32 42 9 9	12.6	VDR, MMP3, INS, TGFB1
10	sorbinil32 9 9	11.4	TIMP2, TIMP1
11	methyl selenol32	9.4	TIMP2, TIMP1
12	beta-ionone32	9.4	TIMP2, TIMP1
13	calcitriol32 42 9 18 9	13.3	TGFB1, TIMP1, SPARC, CALCA, BMP7, VDR
14	streptozotocin32	9.3	TGFB1, TIMP1, INS
15	tgf beta132	9.2	BMP7, MMP3, ACAN, TIMP1
16	pyridinoline32	9.2	MMP3, CALCA, SPARC, TIMP1
17	alginate32	9.1	TGFB1, TIMP1, ACAN, MMP3, BMP7
18	hyaluronic acid32 18	10.0	TIMP2, ACAN, MMP3
19	agarose32	9.0	BMP7, ACAN, TIMP2, TGFB1
20	latanoprost32 9 9	10.9	TIMP2, TIMP1, MMP3
21	(4-aminophenyl)mercuric acetate32	8.9	MMP3, TIMP1, TIMP2
22	hydroxamate32	8.9	TIMP2, TIMP1, MMP3
23	propionate32	8.8	MMP3, TIMP1, TIMP2
24	hydroxyproline32 18	9.8	TGFB1, TIMP2, TIMP1, SPARC, CALCA
25	1,10-phenanthroline32	8.8	TIMP2, TIMP1, MMP3
26	procollagen32	8.8	TGFB1, TIMP1, ACAN, SPARC, MMP3
27	ascorbic acid32 18	9.7	TIMP2, ACAN, SPARC, FTH1, BMP7, VDR
28	batimastat32 42 9 9	11.7	TIMP2, TIMP1, MMP3
29	alendronate32 9 9	10.6	VDR, MMP3, CALCA, TIMP1, TIMP2
30	tacrolimus32 34 9 9	11.6	TGFB1, TIMP2, TIMP1, SPARC, INS, VDR
31	creatinine32	8.6	TGFB1, TIMP2, CALCA, INS, MMP3, BMP7
32	cytochalasin d32 42	9.5	MMP3, TIMP1, TIMP2, TGFB1
33	ribonucleic acid32	8.5	TGFB1, TIMP2, TIMP1, MMP3, BMP7
34	vitamin d32	8.3	TGFB1, TIMP1, ACAN, SPARC, CALCA, MMP3
35	dexamethasone32 42 34 9 9	12.2	TGFB1, TIMP1, ACAN, SPARC, INS, MMP3
36	butyrate32	8.1	TGFB1, TIMP2, TIMP1, SPARC, MMP3, VDR
37	cyclosporin a32 42	9.0	TGFB1, TIMP2, TIMP1, SPARC, CALCA, MMP3
38	lactate32	8.0	TGFB1, TIMP2, TIMP1, SPARC, CALCA, INS
39	pd 98,05932	7.9	MMP3, ACAN, TIMP1, TIMP2, TGFB1
40	cycloheximide32	7.9	TGFB1, TIMP2, TIMP1, MMP3, BMP7, VDR
41	vegf32	7.8	TGFB1, TIMP2, TIMP1, SPARC, CALCA, MMP3
42	sb 20358032 42	8.8	TGFB1, TIMP2, TIMP1, ACAN, SPARC, MMP3
43	estrogen32	7.7	TGFB1, TIMP2, TIMP1, SPARC, CALCA, INS
44	pge232	7.5	TGFB1, TIMP2, TIMP1, ACAN, SPARC, CALCA
45	retinoic acid32 42 18	9.5	TGFB1, TIMP2, TIMP1, ACAN, SPARC, MMP3

Cellular components related to spinal stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	collagen type XI	GO:005592	9.7	COL11A1, COL11A2
2	collagen type IX	GO:005594	9.7	COL9A2, COL9A3, COL9A1
3	platelet alpha granule lumen	GO:031093	9.1	SPARC, TIMP1, TGFB1
4	extracellular space	GO:005615	8.6	KLK8, SPARC, CALCA, INS, MMP3, BMP7
5	endoplasmic reticulum lumen	GO:005788	8.5	ARSD, COL9A1, COL6A1, COL11A1, COL9A3, COL9A2
6	extracellular region	GO:005576	5.4	COL9A1, ACAN, TIMP1, TIMP2, TGFB1, DCD

Biological processes related to spinal stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chondrocyte differentiation	GO:002062	9.5	TGFB1, COL9A1, COL11A2
2	skeletal system development	GO:001501	9.4	ACAN, COL9A2, COL11A2, BMP7, VDR
3	aging	GO:007568	9.4	VDR, CALCA, TIMP1, TGFB1
4	extracellular matrix disassembly	GO:022617	8.5	MMP3, TIMP1, TIMP2
5	extracellular matrix organization	GO:030198	6.9	MMP3, TIMP2, TIMP1, COL9A1, COL6A1, COL11A1

Molecular functions related to spinal stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent conferring tensile strength	GO:030020	9.5	COL11A2, COL9A2, COL9A3, COL9A1