MCID: SPN027
MIFTS: 54

Spinal Stenosis malady

Summaries for Spinal Stenosis

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and radiculopathy. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are RXR and RAR heterodimerization with other nuclear receptor and Endochondral Ossification. The compounds calcium gluconate and etidronic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, spinal cord and bone, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Disease Ontology:8 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia:63 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Aliases & Classifications for Spinal Stenosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

spinal stenosis 8 10 44 33 30 60
spinal stenosis of lumbar region 8 60
spinal stenosis in cervical region 60
cervical spinal stenosis 8
lumbar spinal stenosis 8


Related Diseases for Spinal Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis30.9BMP7, TSSK4, FTH1
2radiculopathy30.5COL6A1, KLK8, HSF4
3osteoarthritis30.5COL11A2, COL9A1, TGFB1, ACAN, VDR, BMP7
4renal osteodystrophy30.2BMP7, VDR, CALCA
5spondylosis30.1COL6A1, TSSK4
6osteoporosis29.9CALCA, TGFB1, VDR, BMP7
7diabetes mellitus29.8CALCA, TGFB1, INS, FTH1, VDR, BMP7
8cervicitis10.6
9intermittent claudication10.4
10achondroplasia10.4
11cauda equina syndrome10.4
12quadriplegia10.3
13hyperostosis10.3
14pseudogout10.2
15osteoporotic fracture10.1
16diffuse idiopathic skeletal hyperostosis10.1
17syringomyelia10.1
18cerebritis10.1
19lipomatosis10.1
20paraplegia10.1
21short stature10.0INS
22myopia 610.0COL11A2
23nephrosclerosis10.0TGFB1
24spondylitis10.0ACAN
25hypothyroidism10.0INS
26hypoparathyroidism10.0CALCA
27hemochromatosis10.0FTH1
28myelodysplastic syndromes10.0VDR
29cataract10.0HSF4
30cleft palate10.0COL11A2
31alpha thalassemia10.0FTH1
32intracranial hypotension10.0HSF4
33hyperparathyroidism10.0VDR, CALCA
34scheuermann's disease10.0COL9A3
35diabetic retinopathy10.0INS
36duodenal ulcer10.0INS
37myopathy10.0INS, COL6A1
38spinal cord disease10.0COL6A1, HSF4
39diastrophic dysplasia10.0COL9A3, COL9A2
40hypogonadism10.0CALCA, INS
41parathyroid adenoma10.0VDR, CALCA
42migraine10.0CALCA
43degenerative disc disease10.0COL9A3, COL9A2
44nephrolithiasis10.0VDR
45graves' disease10.0VDR
46secondary hyperparathyroidism of renal origin10.0CALCA, VDR, BMP7
47thyroid cancer, anaplastic10.0TGFB1, CALCA, BMP7
48proteinuria10.0BMP7, INS, TGFB1
49ureteral disease10.0BMP7, TGFB1
50lumbar disc disease10.0VDR, COL9A3, COL9A2

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to spinal stenosis

Clinical Features for Spinal Stenosis

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Drugs & Therapeutics for Spinal Stenosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spinal Stenosis

Drug clinical trials:

Search ClinicalTrials for Spinal Stenosis

Search NIH Clinical Center for Spinal Stenosis

Search CenterWatch for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spinal Stenosis

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Anatomical Context for Spinal Stenosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Spinal Stenosis:

32
Spinal cord, Bone, Testes, Skin, Brain, Lung, Cortex, Pituitary

FMA organs/tissues related to Spinal Stenosis:

14
Spinal cord

Animal Models for Spinal Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spinal Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6COL9A1, BMP7, ACAN
2MP:00053909.4COL11A2, COL9A1, CALCA, BMP7, VDR, INS

Publications for Spinal Stenosis

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Sources:
50PubMed
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Articles related to Spinal Stenosis:

(show top 50)    (show all 600)
idTitleAuthorsYear
1
Comparative outcomes and cost-utility following surgical treatment ofA focal lumbar spinal stenosis compared with osteoarthritis of the hip orA knee: part 2-estimated lifetime incremental cost-utility ratios. (24239803)
2014
2
Progression of lumbar spinal stenosis is influenced by polymorphism of thrombospondin 2 gene in the Korean population. (23807322)
2014
3
Clinical features and surgical outcomes of lumbar spinal stenosis in patients aged 80A years or older: a multi-center retrospective study. (23852590)
2013
4
Modified Unilateral Laminotomy for Bilateral Decompression for Lumbar Spinal Stenosis-Technical Note. (23466507)
2013
5
Lumbar spinal stenosis due to a large calcified mass in the ligamentum flavum. (24066222)
2013
6
Depression as a prognostic factor of lumbar spinal stenosis: a systematic review. (24417814)
2013
7
Socioeconomic and physical characteristics of degenerative lumbar spinal stenosis individuals. (23380820)
2013
8
Minimally invasive unilateral approach for bilateral decompression of spinal stenosis and modified transforaminal lumbar interbody fusion for degenerative spondylolisthesis. (23829853)
2013
9
Re: Radcliff K, Kepler C, Hilibrand A, et al. Epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis: a subgroup analysis of the spine patient outcomes research trial. Spine (Phila Pa 1976). 2013;38:279a8991. (23900110)
2013
10
Epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis: a subgroup analysis of the Spine Patient Outcomes Research Trial. (23238485)
2013
11
Uncertainties in the measurement of lumbar spinal stenosis at MR imaging: are they clinically relevant? (22438456)
2012
12
A case of Proteus syndrome with severe spinal canal stenosis, scoliosis, and thoracic deformity associated with tethered cord. (22223075)
2012
13
Interspinous distractor devices for the management of lumbar spinal stenosis: a miracle cure for a common problem? (22582741)
2012
14
Injectate Volumes Needed to Reach Specific Landmarks and Contrast Pattern in Kambin's Triangle Approach with Spinal Stenosis. (22977773)
2012
15
Correlation of low back pain caused by lumbar spinal stenosis and depression in women: a clinical study. (22491968)
2012
16
Intraosseous ganglion cyst within the L4 lamina causing spinal stenosis. (23158970)
2012
17
Relationship between ambulatory performance and self-rated disability in patients with lumbar spinal stenosis. (22261635)
2012
18
Biomechanical analysis in a human cadaveric model of spinous process fixation with an interlaminar allograft spacer for lumbar spinal stenosis: Laboratory investigation. (22519928)
2012
19
Clinical evaluation of the preliminary safety and effectiveness of a minimally invasive interspinous process device APERIUS(Ar) in degenerative lumbar spinal stenosis with symptomatic neurogenic intermittent claudication. (22565799)
2012
20
Predominant leg pain is associated with better surgical outcomes in degenerative spondylolisthesis and spinal stenosis: results from the Spine Patient Outcomes Research Trial (SPORT). (21124260)
2011
21
Cervical spinal stenosis and sports-related cervical cord neurapraxia. (22044106)
2011
22
Smokers show less improvement than nonsmokers two years after surgery for lumbar spinal stenosis: a study of 4555 patients from the Swedish spine register. (21224770)
2011
23
Quantitative radiologic criteria for the diagnosis of lumbar spinal stenosis: a systematic literature review. (21798008)
2011
24
Postoperative improvement in health-related quality of life: a national comparison of surgical treatment for focal (one- to two-level) lumbar spinal stenosis compared with total joint arthroplasty for osteoarthritis. (22122836)
2011
25
Prognosis of surgical treatment for degenerative lumbar spinal stenosis: a prospective cohort study of clinical outcomes and health-related quality of life across gender and age groups. (22135713)
2011
26
Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia. (21206180)
2010
27
Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. (21034148)
2010
28
Erratum: interspinous implant with unilateral laminotomy for bilateral decompression of degenerative lumbar spinal stenosis in elderly patients. (20617100)
2010
29
Fluoroscopically guided transforaminal epidural dry needling for lumbar spinal stenosis using a specially designed needle. (20698999)
2010
30
The results of decompression and instrumented fusion with pedicular screw plate system in degenerative lumbar scoliosis patients with spinal stenosis: a prospective observational study. (20462089)
2010
31
Efficacy of exercise and ultrasound in patients with lumbar spinal stenosis: a prospective randomized controlled trial. (20530650)
2010
32
Continuous intraoperative electromyographic and transcranial motor evoked potential recordings in spinal stenosis surgery. (20006509)
2010
33
Spinal stenosis: example of computed tomography findings. (20450137)
2010
34
Assessment and management of neurogenic claudication associated with lumbar spinal stenosis in a UK primary care musculoskeletal service: a survey of current practice among physiotherapists. (19796387)
2009
35
Midterm outcome after microendoscopic decompressive laminotomy for lumbar spinal stenosis: 4-year prospective study. (19574831)
2009
36
Effect of intervertebral disk degeneration on spinal stenosis during magnetic resonance imaging with axial loading. (19556732)
2009
37
The influence of coughing on cerebrospinal fluid pressure in an in vitro syringomyelia model with spinal subarachnoid space stenosis. (20043856)
2009
38
Modified fenestration with restorative spinoplasty for lumbar spinal stenosis. (19558293)
2009
39
Bilateral pedicle stress fracture in a patient with lumbar spinal stenosis: a case report. (18836368)
2008
40
Surgical results in hidden lumbar spinal stenosis detected by axial loaded computed tomography and magnetic resonance imaging: an outcome study. (18277859)
2008
41
Predictive value of self-reported patient information for the identification of lumbar spinal stenosis. (18552358)
2008
42
Identification and surgical treatment of primary thoracic spinal stenosis. (19104683)
2008
43
Role of psoas compartment and caudal epidural steroid injection in spinal stenosis patients associated with low back pain and lower limb radiculopathy. (18846797)
2008
44
Brachyolmia and spinal stenosis. (12833413)
2003
45
Herrmann multiple synostosis syndrome with neurological complications caused by spinal canal stenosis. (11078560)
2000
46
Cervical spinal stenosis with cord neurapraxia and transient quadriplegia. (8614762)
1995
47
Pseudohypoparathyroidism-associated spinal stenosis. (8059279)
1994
48
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993
49
A technique for necropsy evaluation of stenosis of the foramen magnum and rostral spinal canal in osteochondrodysplasia. (3192205)
1988
50
Pituitary gigantism with cervical spinal stenosis. (6766014)
1980

Genetic Variations for Spinal Stenosis

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Expression for genes affiliated with Spinal Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for genes affiliated with Spinal Stenosis

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
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Pathways related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TGFB1, VDR
210.0BMP7, ACAN, TGFB1
3
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10.0COL9A1, COL6A1, COL11A2
49.9TGFB1, ACAN, KLK8
5
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9.8COL6A1, COL9A1, COL9A2, COL9A3
6
Hide members
9.8COL6A1, COL9A1, COL9A2, COL9A3
7
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9.7COL9A3, COL9A2, COL9A1, COL6A1, COL11A2
8
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9.7COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
99.7COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
10
Hide members
9.4COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, BMP7
11
Hide members
9.4COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, BMP7
12
Hide members
9.1ACAN, KLK8, COL11A2, COL6A1, COL9A1, COL9A2

Compounds for genes affiliated with Spinal Stenosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1calcium gluconate4410.5INS, CALCA
2etidronic acid44 49 1112.4CALCA, VDR
3safranin o4410.4BMP7, ACAN
4thiazide4410.4INS, VDR, CALCA
5dmsa4410.4VDR, CALCA
6alfacalcidol44 59 1112.3CALCA, VDR
7alginate4410.3BMP7, ACAN, TGFB1
824,25-dihydroxyvitamin d34410.3CALCA, VDR
9thyroxine44 2411.2TGFB1, INS, VDR, CALCA
10calcitriol44 59 11 2413.2TGFB1, VDR, BMP7, CALCA
11i-app4410.1CALCA, INS
121,25 dihydroxy vitamin d34410.1TGFB1, VDR, CALCA
13vitamin d4410.0CALCA, BMP7, VDR, ACAN, TGFB1
14pge24410.0CALCA, BMP7, VDR, ACAN, TGFB1
15creatinine449.9CALCA, BMP7, VDR, INS, TGFB1
16pramlintide44 1110.9INS, CALCA
17ascorbic acid44 2410.8ACAN, FTH1, VDR, BMP7

GO Terms for genes affiliated with Spinal Stenosis

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16Gene Ontology
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Cellular components related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0TGFB1, ACAN, INS
2collagen type IXGO:0055949.6COL9A1, COL9A2, COL9A3
3endoplasmic reticulum lumenGO:0057889.2COL9A2, COL9A3, ARSD, INS, COL9A1, COL6A1
4extracellular regionGO:0055768.6COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, CALCA

Biological processes related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ossificationGO:03027910.2TGFB1, CALCA
2positive regulation of cellular protein metabolic processGO:03227010.1TGFB1, INS
3positive regulation of peptidyl-threonine phosphorylationGO:0108009.9TGFB1, BMP7
4collagen catabolic processGO:0305749.8COL9A3, COL11A2, COL6A1, COL9A1, COL9A2
5extracellular matrix disassemblyGO:0226179.8COL9A2, COL9A1, COL6A1, COL11A2, COL9A3
6skeletal system developmentGO:0015019.8ACAN, COL9A2, BMP7, COL11A2, VDR
7axon guidanceGO:0074119.7COL9A1, COL6A1, COL9A3, BMP7, COL9A2
8extracellular matrix organizationGO:0301989.4TGFB1, BMP7, COL9A3, COL9A2, COL9A1, COL6A1

Molecular functions related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.8COL9A3, COL9A2, COL9A1, COL11A2

Products for genes affiliated with Spinal Stenosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spinal Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet