MCID: SPN027
MIFTS: 61

Spinal Stenosis malady

Neuronal diseases category

Summaries for Spinal Stenosis

About this section


MedlinePlus:34 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and osteoarthritis. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endochondral Ossification and RXR and RAR heterodimerization with other nuclear receptor. The compounds calcium gluconate and safranin o have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Disease Ontology:10 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia:65 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Aliases & Classifications for Spinal Stenosis

About this section

Spinal Stenosis, Aliases & Descriptions:

Name: Spinal Stenosis 32 10 12 45 34 62
Spinal Stenosis of Lumbar Region 10 62
Spinal Stenosis in Cervical Region 62
 
Cervical Spinal Stenosis 10
Lumbar Spinal Stenosis 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Related Diseases for Spinal Stenosis

About this section

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis31.1TSSK4, BMP7, LSS
2osteoarthritis30.3COL9A3, COL9A1, COL9A2, TGFB1, VDR, TIMP1
3renal osteodystrophy30.3VDR, BMP7, CALCA
4spondylosis30.2TSSK4, COL6A1
5osteoporosis29.9CALCA, VDR
6cervicitis10.7
7back pain10.6
8achondroplasia10.5
9blindness10.4
10intermittent claudication10.4
11cauda equina syndrome10.4
12radiculopathy10.4
13scoliosis10.4
14quadriplegia10.3
15hyperostosis10.3
16peripheral artery disease10.2
17artery disease10.2
18paraplegia10.2
19syringomyelia10.1
20diffuse idiopathic skeletal hyperostosis10.1
21cerebritis10.1
22lipomatosis10.1
23central cord syndrome10.1
24foot drop10.1
25spondylitis10.1ACAN
26degenerative disc disease10.1ACAN, COL9A3
27ureteral obstruction10.1TGFB1, BMP7
28ureteral disease10.1BMP7, TGFB1
29fibrochondrogenesis10.1COL11A1
30intervertebral disc disease10.0COL9A3, COL9A2
31osteochondrodysplasia10.0COL11A2, ACAN
32pulpitis10.0TIMP1
33thyroid cancer, anaplastic10.0CALCA, BMP7, TGFB1
34diastrophic dysplasia10.0COL9A3, COL9A2
35giant cell tumor10.0TIMP1, TGFB1
36proteinuria10.0BMP7, INS, TGFB1
37multiple epiphyseal dysplasia, dominant10.0COL9A1, COL9A2, COL9A3
38pseudoachondroplasia10.0COL9A1, COL9A2, COL9A3
39hypertension, essential10.0INS, TGFB1, CALCA
40pulmonary disease, chronic obstructive10.0TGFB1, TIMP1
41biliary atresia10.0TGFB1, TIMP1
42renal fibrosis10.0TIMP1, TGFB1, BMP7
43multiple epiphyseal dysplasia10.0COL9A1, ACAN, COL9A2, COL9A3
44osteochondritis dissecans10.0ACAN, COL9A2, COL9A3, COL9A1
45liver disease10.0TGFB1, INS, TIMP1
46hypertrophic scars10.0TGFB1, TIMP1
47vitreoretinopathy, neovascular inflammatory10.0TGFB1, TIMP1, TIMP2
48myelofibrosis10.0TIMP1, TGFB1, TIMP2
49secondary hyperparathyroidism of renal origin10.0VDR, BMP7, CALCA
50secondary syphilis10.0CALCA, BMP7, VDR

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to spinal stenosis

Symptoms for Spinal Stenosis

About this section

Drugs & Therapeutics for Spinal Stenosis

About this section

Drug clinical trials:

Search ClinicalTrials for Spinal Stenosis

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spinal Stenosis

About this section

Anatomical Context for Spinal Stenosis

About this section

MalaCards organs/tissues related to Spinal Stenosis:

33
Spinal cord, Bone, Testes, Skin, Brain, Lung, Pituitary

FMA organs/tissues related to Spinal Stenosis:

16
Spinal cord

Animal Models for Spinal Stenosis or affiliated genes

About this section

Publications for Spinal Stenosis

About this section

Articles related to Spinal Stenosis:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Problem areas identified as important to older adults with lumbar spinal stenosis. (25791366)
2015
2
Lumbar spinal stenosis-specific symptom scale: validity and responsiveness. (25365718)
2014
3
Clinical Outcome and Postoperative CT Measurements of Microendoscopic Decompression for Lumbar Spinal Stenosis. (25286170)
2014
4
Spinal stenosis. (24365318)
2014
5
Predictors of objectively measured walking capacity in people with degenerative lumbar spinal stenosis. (23948821)
2013
6
Clinical features and surgical outcomes of lumbar spinal stenosis in patients aged 80A years or older: a multi-center retrospective study. (23852590)
2013
7
Obesity is associated with inferior results after surgery for lumbar spinal stenosis: a study of 2633 patients from the Swedish spine register. (22941097)
2013
8
Symptomatic progression of degenerative scoliosis after decompression and limited fusion surgery for lumbar spinal stenosis. (23274034)
2013
9
Lumbar spinal stenosis. (23395043)
2013
10
Re: Macedo LG, Wang Y, BattiAc MC. The sedimentation sign for differential diagnosis of lumbar spinal stenosis. [published online ahead of print November 28, 2012.] Spine. doi:10.1097/BRS.0b013e31827e8ecd. (23660806)
2013
11
Lumbar spinal stenosis impairs function following total knee arthroplasty. (23288774)
2013
12
Spinal Stenosis: Factors That Influence Patients' Decision to Undergo Surgery. (23839025)
2013
13
A comparison of the clinical outcomes of decompression alone and fusion in elderly patients with two-level or more lumbar spinal stenosis. (23440621)
2013
14
Disparities in the outcomes of lumbar spinal stenosis surgery based on insurance status. (23354106)
2013
15
Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. (23473979)
2013
16
Zoster-associated segmental paresis in a patient with cervical spinal stenosis. (23628922)
2013
17
Unilateral approach for bilateral decompression of lumbar spinal stenosis: a minimal invasive surgery. (24304987)
2013
18
Modified Unilateral Laminotomy for Bilateral Decompression for Lumbar Spinal Stenosis-Technical Note. (23466507)
2013
19
Lumbar spinal stenosis: treatment options for an aging population. (23362650)
2012
20
Commentary: Validity and responsiveness of measures of walking in lumbar spinal stenosis--what are we measuring? (22405613)
2012
21
Accuracy and reproducibility of a retrospective outcome assessment for lumbar spinal stenosis surgery. (22642923)
2012
22
Complications in patients undergoing combined transforaminal lumbar interbody fusion and posterior instrumentation with deformity correction for degenerative scoliosis and spinal stenosis. (22439116)
2012
23
Large C4/5 spondylotic disc bulge resulting in spinal stenosis and myelomalacia in a Klippel-Feil patient. (22268974)
2012
24
Commentary: Predictors of outcome from operative management of lumbar spinal stenosis: a plea for better design and reporting practices. (21821199)
2011
25
Lumbar spinal stenosis-diagnosis and management of the aging spine. (21367646)
2011
26
Life dissatisfaction in the pre-operative and early recovery phase predicts low functional ability and coping among post-operative patients with lumbar spinal stenosis: a 2-year prospective study. (20874450)
2011
27
MRI criteria of developmental lumbar spinal stenosis revisited. (22196386)
2011
28
Depression is associated with a poorer outcome of lumbar spinal stenosis surgery: a two-year prospective follow-up study. (21037530)
2011
29
Prospective analysis of surgical outcomes in patients undergoing decompressive laminectomy and posterior instrumentation for degenerative lumbar spinal stenosis. (21088465)
2010
30
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications. (20861423)
2010
31
Contemporary management of symptomatic lumbar spinal stenosis. (20399357)
2010
32
Spinal cord injury in cervical spinal stenosis by minor trauma. (20452868)
2010
33
Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia. (21206180)
2010
34
Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. (21034148)
2010
35
Technical advances in minimally invasive surgery: direct decompression for lumbar spinal stenosis. (21160392)
2010
36
ACP Journal Club. Review: Evidence for the effectiveness of surgery for low back pain, radiculopathy, and spinal stenosis is limited. (19841448)
2009
37
Assessment and management of neurogenic claudication associated with lumbar spinal stenosis in a UK primary care musculoskeletal service: a survey of current practice among physiotherapists. (19796387)
2009
38
Chiropractic treatment of lumbar spinal stenosis: a review of the literature. (19646390)
2009
39
Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis. (19190056)
2009
40
Efficacy of surgery and type of fusion in patients with degenerative lumbar spinal stenosis. (19577930)
2009
41
The clinical effect of gait load test in two level lumbar spinal stenosis. (20404954)
2009
42
Clinical practice. Lumbar spinal stenosis. (18287604)
2008
43
Endoscopic decompression combined with interspinous process implant fusion for lumbar spinal stenosis. (19032852)
2008
44
Surgery may be best way to relieve symptoms of spinal stenosis. (18667961)
2008
45
Clinical outcome of microendoscopic posterior decompression for spinal stenosis associated with degenerative spondylolisthesis--minimum 2-year outcome of 37 patients. (18855290)
2008
46
Degenerative cervical spinal stenosis: current strategies in diagnosis and treatment. (19626174)
2008
47
Spinal stenosis in grade I degenerative lumbar spondylolisthesis: a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion. (15928889)
2005
48
Outcomes of decompression surgery for lumbar spinal stenosis in elderly diabetic patients. (14614597)
2004
49
Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. (11679833)
2001
50
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993

Variations for Spinal Stenosis

About this section

Expression for genes affiliated with Spinal Stenosis

About this section

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for genes affiliated with Spinal Stenosis

About this section

Pathways related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TGFB1, ACAN, BMP7
29.7TGFB1, VDR
39.7COL9A2, COL9A3, COL9A1
49.6TGFB1, COL11A2, COL11A1
59.5TGFB1, TIMP1, TIMP2
69.5ACAN, MMP3, TIMP2
7
Show member pathways
9.3COL9A1, COL9A3, COL9A2, COL6A1
8
Show member pathways
9.3COL6A1, COL9A2, COL9A3, COL9A1
9
Show member pathways
9.3TIMP2, TIMP1, TGFB1, BMP7
10
Show member pathways
9.3TIMP1, TGFB1, BMP7, TIMP2
11
Show member pathways
9.3BMP7, TGFB1, TIMP1, TIMP2
129.3COL11A1, COL6A1, COL11A2, INS
13
Show member pathways
9.3TIMP2, TIMP1, MMP3
149.2TGFB1, ACAN, COL9A2, COL9A3, COL9A1
15
Show member pathways
9.1INS, TIMP2, TIMP1, TGFB1, BMP7
16
Show member pathways
9.1BMP7, TGFB1, TIMP1, TIMP2, INS
17
Show member pathways
9.1INS, TIMP2, TIMP1, TGFB1, BMP7
18
Show member pathways
9.1TIMP2, TIMP1, MMP3, ACAN
19
Show member pathways
8.9INS, TGFB1, COL6A1, COL9A2, COL9A3, COL9A1
20
Show member pathways
8.8TIMP2, TIMP1, TGFB1, MMP3, BMP7
218.7COL11A2, COL6A1, COL9A2, COL11A1, COL9A3, COL9A1
22
Show member pathways
8.2MMP3, COL11A2, COL6A1, COL9A2, COL11A1, COL9A3
23
Show member pathways
8.2INS, TGFB1, MMP3, COL6A1, COL9A2, COL9A3
24
Show member pathways
8.0TGFB1, MMP3, COL11A2, COL6A1, COL9A2, COL11A1
25
Show member pathways
7.5TIMP2, TIMP1, TGFB1, BMP7, COL11A2, COL6A1
26
Show member pathways
7.5BMP7, TGFB1, TIMP1, TIMP2, COL11A2, COL6A1
27
Show member pathways
6.8COL9A1, TIMP2, TIMP1, TGFB1, MMP3, ACAN

Compounds for genes affiliated with Spinal Stenosis

About this section

Compounds related to Spinal Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1calcium gluconate4510.2INS, CALCA
2safranin o4510.0MMP3, BMP7, ACAN
3methyl selenol459.9TIMP1, TIMP2
4sorbinil45 1310.9TIMP2, TIMP1
5thiazide459.9CALCA, INS, VDR
6rhein459.8TIMP1, TGFB1
7agarose459.8BMP7, TIMP2, ACAN, TGFB1
8pyridinoline459.8MMP3, CALCA, TIMP1
9hydroxyproline45 26 1311.7TGFB1, TIMP2, TIMP1, CALCA
10streptozotocin459.7TIMP1, INS, TGFB1
11latanoprost45 1310.7TIMP2, MMP3, TIMP1
12(4-aminophenyl)mercuric acetate459.7MMP3, TIMP2, TIMP1
13deoxypyridinoline459.6VDR, MMP3, CALCA
14beta-ionone459.6TIMP2, TIMP1
15hydroxamate459.6TIMP1, MMP3, TIMP2
16thyroxine45 2610.6INS, VDR, CALCA, TGFB1
17propionate459.6TIMP1, TIMP2, MMP3
18procollagen459.6ACAN, TGFB1, MMP3, TIMP1
191,10-phenanthroline45 310.5TIMP2, MMP3, TIMP1
20batimastat45 61 1311.5MMP3, TIMP1, TIMP2
21etidronic acid45 51 1311.5CALCA, VDR
22alginate459.4ACAN, MMP3, TGFB1, BMP7, TIMP1
23tgf beta1459.4BMP7, TGFB1, ACAN, TIMP1, MMP3
24troglitazone45 30 61 1312.4VDR, INS, MMP3, TGFB1
25cytochalasin d45 6110.4TIMP2, MMP3, TIMP1, TGFB1
26calcitriol45 61 26 1312.3VDR, CALCA, BMP7, TGFB1, TIMP1
27glycosaminoglycan459.3TIMP2, ACAN, MMP3, TGFB1, TIMP1
28hyaluronic acid45 2610.3ACAN, TIMP2, MMP3, TGFB1, TIMP1
29ribonucleic acid459.2TIMP2, BMP7, MMP3, TIMP1, TGFB1
30pd 98,059459.2MMP3, ACAN, TGFB1, TIMP1, TIMP2
31glyceraldehyde 3-phosphate459.2ACAN, TIMP2, TIMP1, MMP3
32tacrolimus45 51 1311.2INS, TIMP2, TIMP1, VDR, TGFB1
33ascorbic acid45 2610.1ACAN, BMP7, MMP3, TIMP2, VDR
34methotrexate51 45 1311.0MMP3, TIMP2, TGFB1, TIMP1
35lactate459.0CALCA, MMP3, TIMP1, TIMP2, TGFB1, INS
36alendronate45 51 1311.0TIMP2, TIMP1, MMP3, CALCA, VDR
37vegf458.9CALCA, MMP3, TGFB1, TIMP1, TIMP2, BMP7
38glutamine458.9VDR, COL9A2, MMP3, TGFB1, TIMP1
39butyrate458.9TGFB1, TIMP1, TIMP2, VDR, MMP3
40sb 20358045 619.8VDR, ACAN, TIMP2, TIMP1, TGFB1, MMP3
41creatinine458.7INS, TGFB1, MMP3, BMP7, CALCA, VDR
42cyclosporin a45 30 6110.7VDR, TIMP2, TIMP1, TGFB1, MMP3, CALCA
43glutamate458.7INS, VDR, TIMP1, MMP3, ACAN, CALCA
44cycloheximide458.7BMP7, TIMP1, VDR, MMP3, TGFB1, TIMP2
45vitamin d458.7TGFB1, MMP3, CALCA, VDR, ACAN, BMP7
46dexamethasone45 51 30 1311.6VDR, TIMP1, BMP7, TGFB1, ACAN, MMP3
47alanine458.5INS, TGFB1, VDR, TIMP2, TIMP1, MMP3
48retinoic acid45 269.5BMP7, ACAN, TGFB1, TIMP1, VDR, TIMP2
49pge2458.4CALCA, BMP7, MMP3, ACAN, TIMP2, TIMP1
50estrogen458.3TIMP1, MMP3, INS, VDR, TIMP2, BMP7

GO Terms for genes affiliated with Spinal Stenosis

About this section

Cellular components related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type XIGO:00055929.8COL11A1, COL11A2
2extracellular matrixGO:00310129.7COL6A1, BMP7, ACAN
3collagen type IXGO:00055949.7COL9A2, COL9A3, COL9A1
4Golgi lumenGO:00057969.5ACAN, TGFB1, INS
5extracellular spaceGO:00056158.7INS, TIMP2, TGFB1, MMP3, BMP7, CALCA
6endoplasmic reticulum lumenGO:00057888.6INS, COL11A2, COL6A1, COL9A2, COL11A1, COL9A3
7extracellular regionGO:00055765.7CALCA, INS, TIMP2, TIMP1, DCD, TGFB1

Biological processes related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:003328010.2TGFB1, BMP7
2positive regulation of cellular protein metabolic processGO:003227010.2TGFB1, INS
3negative regulation of ossificationGO:003027910.2TGFB1, CALCA
4positive regulation of peptidyl-threonine phosphorylationGO:001080010.2TGFB1, BMP7
5positive regulation of adenylate cyclase activityGO:004576210.2CALCA, TIMP2
6positive regulation of vasodilationGO:004590910.1CALCA, INS
7negative regulation of proteolysisGO:004586110.0TIMP2, INS
8negative regulation of mitotic cell cycleGO:00459309.9TGFB1, TIMP2
9positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8BMP7, TGFB1
10agingGO:00075689.6CALCA, TGFB1, TIMP1, TIMP2
11axon guidanceGO:00074119.4BMP7, COL6A1, COL9A2, COL9A3, COL9A1
12skeletal system developmentGO:00015019.3VDR, ACAN, BMP7, COL11A2, COL9A2
13negative regulation of transcription, DNA-templatedGO:00458929.2VDR, TGFB1, BMP7, CALCA
14collagen catabolic processGO:00305748.5MMP3, COL11A2, COL6A1, COL9A2, COL11A1, COL9A3
15extracellular matrix disassemblyGO:00226177.6COL9A3, COL11A1, COL9A2, COL6A1, COL11A2, ACAN
16extracellular matrix organizationGO:00301987.1COL9A1, TIMP2, TIMP1, COL9A3, COL11A1, COL9A2

Molecular functions related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00081919.4TIMP2, TIMP1
2extracellular matrix structural constituent conferring tensile strengthGO:00300209.3COL9A1, COL9A3, COL9A2, COL11A2
3protein bindingGO:00055157.6INS, TIMP2, TIMP1, TGFB1, TSSK4, ACAN

Products for genes affiliated with Spinal Stenosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Spinal Stenosis

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet