MCID: SPN027
MIFTS: 63

Spinal Stenosis malady

Bone diseases, Neuronal diseases categories
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Summaries for Spinal Stenosis

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MedlinePlus:33 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and spondylosis. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endochondral Ossification and RXR and RAR heterodimerization with other nuclear receptor. The compounds calcium gluconate and safranin o have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Disease Ontology:8 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia:65 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Aliases & Classifications for Spinal Stenosis

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Spinal Stenosis, Aliases & Descriptions:

Name: Spinal Stenosis 30 8 10 44 33 62
Spinal Stenosis of Lumbar Region 8 62
Spinal Stenosis in Cervical Region 62
 
Cervical Spinal Stenosis 8
Lumbar Spinal Stenosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Neuronal diseases


Related Diseases for Spinal Stenosis

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Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis31.4TSSK4, BMP7, LSS
2spondylosis30.8TSSK4, COL6A1
3renal osteodystrophy30.5CALCA, BMP7, VDR
4hypertension30.4INS, TGFB1, CALCA
5osteoporosis29.6VDR, TGFB1, MMP3, BMP7, CALCA
6diabetes mellitus29.5VDR, INS, TGFB1, MMP3, BMP7, CALCA
7osteoarthritis28.8TGFB1, TIMP1, TIMP2, VDR, MMP3, ACAN
8cervicitis10.7
9back pain10.6
10spondylitis10.5ACAN
11ureteral disease10.4TGFB1, BMP7
12achondroplasia10.4
13blindness10.4
14ureteral obstruction10.4TGFB1, BMP7
15fibrochondrogenesis10.4COL11A1
16degenerative disc disease10.4COL9A3, COL9A2
17intermittent claudication10.4
18radiculopathy10.4
19osteochondrodysplasia10.4ACAN, COL11A2
20cauda equina syndrome10.4
21pulpitis10.4TIMP1
22thyroid cancer, anaplastic10.4CALCA, BMP7, TGFB1
23diastrophic dysplasia10.4COL9A2, COL9A3
24lumbar disc herniation10.4
25lung giant cell carcinoma10.3TGFB1, TIMP1
26quadriplegia10.3
27hyperostosis10.3
28proteinuria10.3INS, TGFB1, BMP7
29multiple epiphyseal dysplasia, dominant10.3COL9A1, COL9A3, COL9A2
30pseudoachondroplasia10.3COL9A2, COL9A3, COL9A1
31chronic obstructive pulmonary disease10.3TIMP1, TGFB1
32biliary atresia10.3TIMP1, TGFB1
33renal fibrosis10.2TIMP1, TGFB1, BMP7
34osteochondritis dissecans10.2ACAN, COL9A1, COL9A3, COL9A2
35multiple epiphyseal dysplasia10.2COL9A1, COL9A3, COL9A2, ACAN
36pseudogout10.2
37peripheral artery disease10.2
38artery disease10.2
39paraplegia10.2
40galactosemia10.2INS, TIMP1, TGFB1
41hypertrophic scars10.2TGFB1, TIMP1
42proliferative vitreoretinopathy10.2TIMP2, TIMP1, TGFB1
43myelofibrosis10.1TIMP2, TIMP1, TGFB1
44secondary hyperparathyroidism of renal origin10.1VDR, BMP7, CALCA
45syringomyelia10.1
46diffuse idiopathic skeletal hyperostosis10.1
47cerebritis10.1
48lipomatosis10.1
49central cord syndrome10.1
50foot drop10.1

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to spinal stenosis

Symptoms for Spinal Stenosis

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Drugs & Therapeutics for Spinal Stenosis

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Drug clinical trials:

Search ClinicalTrials for Spinal Stenosis

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spinal Stenosis

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Anatomical Context for Spinal Stenosis

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MalaCards organs/tissues related to Spinal Stenosis:

32
Spinal cord, Bone, Testes, Skin, Brain, Lung, Pituitary

FMA organs/tissues related to Spinal Stenosis:

14
Spinal cord

Animal Models for Spinal Stenosis or affiliated genes

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Publications for Spinal Stenosis

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Articles related to Spinal Stenosis:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
Lumbar spinal stenosis-specific symptom scale: validity and responsiveness. (25365718)
2014
2
Clinical Outcome and Postoperative CT Measurements of Microendoscopic Decompression for Lumbar Spinal Stenosis. (25286170)
2014
3
Spinal stenosis. (24365318)
2014
4
Predictors of objectively measured walking capacity in people with degenerative lumbar spinal stenosis. (23948821)
2013
5
Clinical features and surgical outcomes of lumbar spinal stenosis in patients aged 80A years or older: a multi-center retrospective study. (23852590)
2013
6
Obesity is associated with inferior results after surgery for lumbar spinal stenosis: a study of 2633 patients from the Swedish spine register. (22941097)
2013
7
Symptomatic progression of degenerative scoliosis after decompression and limited fusion surgery for lumbar spinal stenosis. (23274034)
2013
8
Lumbar spinal stenosis. (23395043)
2013
9
Re: Macedo LG, Wang Y, BattiAc MC. The sedimentation sign for differential diagnosis of lumbar spinal stenosis. [published online ahead of print November 28, 2012.] Spine. doi:10.1097/BRS.0b013e31827e8ecd. (23660806)
2013
10
Lumbar spinal stenosis impairs function following total knee arthroplasty. (23288774)
2013
11
Spinal Stenosis: Factors That Influence Patients' Decision to Undergo Surgery. (23839025)
2013
12
A comparison of the clinical outcomes of decompression alone and fusion in elderly patients with two-level or more lumbar spinal stenosis. (23440621)
2013
13
Disparities in the outcomes of lumbar spinal stenosis surgery based on insurance status. (23354106)
2013
14
Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. (23473979)
2013
15
Zoster-associated segmental paresis in a patient with cervical spinal stenosis. (23628922)
2013
16
Unilateral approach for bilateral decompression of lumbar spinal stenosis: a minimal invasive surgery. (24304987)
2013
17
Modified Unilateral Laminotomy for Bilateral Decompression for Lumbar Spinal Stenosis-Technical Note. (23466507)
2013
18
Lumbar spinal stenosis: treatment options for an aging population. (23362650)
2012
19
Commentary: Validity and responsiveness of measures of walking in lumbar spinal stenosis--what are we measuring? (22405613)
2012
20
Accuracy and reproducibility of a retrospective outcome assessment for lumbar spinal stenosis surgery. (22642923)
2012
21
Complications in patients undergoing combined transforaminal lumbar interbody fusion and posterior instrumentation with deformity correction for degenerative scoliosis and spinal stenosis. (22439116)
2012
22
Large C4/5 spondylotic disc bulge resulting in spinal stenosis and myelomalacia in a Klippel-Feil patient. (22268974)
2012
23
Commentary: Predictors of outcome from operative management of lumbar spinal stenosis: a plea for better design and reporting practices. (21821199)
2011
24
Lumbar spinal stenosis-diagnosis and management of the aging spine. (21367646)
2011
25
Life dissatisfaction in the pre-operative and early recovery phase predicts low functional ability and coping among post-operative patients with lumbar spinal stenosis: a 2-year prospective study. (20874450)
2011
26
MRI criteria of developmental lumbar spinal stenosis revisited. (22196386)
2011
27
Depression is associated with a poorer outcome of lumbar spinal stenosis surgery: a two-year prospective follow-up study. (21037530)
2011
28
Prospective analysis of surgical outcomes in patients undergoing decompressive laminectomy and posterior instrumentation for degenerative lumbar spinal stenosis. (21088465)
2010
29
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications. (20861423)
2010
30
Contemporary management of symptomatic lumbar spinal stenosis. (20399357)
2010
31
Spinal cord injury in cervical spinal stenosis by minor trauma. (20452868)
2010
32
Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia. (21206180)
2010
33
Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. (21034148)
2010
34
Technical advances in minimally invasive surgery: direct decompression for lumbar spinal stenosis. (21160392)
2010
35
ACP Journal Club. Review: Evidence for the effectiveness of surgery for low back pain, radiculopathy, and spinal stenosis is limited. (19841448)
2009
36
Assessment and management of neurogenic claudication associated with lumbar spinal stenosis in a UK primary care musculoskeletal service: a survey of current practice among physiotherapists. (19796387)
2009
37
Chiropractic treatment of lumbar spinal stenosis: a review of the literature. (19646390)
2009
38
Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis. (19190056)
2009
39
Efficacy of surgery and type of fusion in patients with degenerative lumbar spinal stenosis. (19577930)
2009
40
The clinical effect of gait load test in two level lumbar spinal stenosis. (20404954)
2009
41
Clinical practice. Lumbar spinal stenosis. (18287604)
2008
42
Endoscopic decompression combined with interspinous process implant fusion for lumbar spinal stenosis. (19032852)
2008
43
Surgery may be best way to relieve symptoms of spinal stenosis. (18667961)
2008
44
Clinical outcome of microendoscopic posterior decompression for spinal stenosis associated with degenerative spondylolisthesis--minimum 2-year outcome of 37 patients. (18855290)
2008
45
Degenerative cervical spinal stenosis: current strategies in diagnosis and treatment. (19626174)
2008
46
Lumbar spinal stenosis. (18557179)
2008
47
Spinal stenosis in grade I degenerative lumbar spondylolisthesis: a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion. (15928889)
2005
48
Outcomes of decompression surgery for lumbar spinal stenosis in elderly diabetic patients. (14614597)
2004
49
Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. (11679833)
2001
50
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993

Variations for Spinal Stenosis

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Expression for genes affiliated with Spinal Stenosis

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Expression patterns in normal tissues for genes affiliated with Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for genes affiliated with Spinal Stenosis

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Pathways related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8BMP7, ACAN, TGFB1
29.7TGFB1, VDR
39.7COL9A2, COL9A3, COL9A1
49.6COL11A1, TGFB1, COL11A2
59.5TIMP2, TGFB1, TIMP1
69.5TIMP2, MMP3, ACAN
7
Show member pathways
9.3COL9A1, COL6A1, COL9A3, COL9A2
8
Show member pathways
9.3COL6A1, COL9A2, COL9A3, COL9A1
9
Show member pathways
9.3BMP7, TIMP2, TIMP1, TGFB1
10
Show member pathways
9.3TIMP2, TIMP1, TGFB1, BMP7
11
Show member pathways
9.3TIMP2, TIMP1, BMP7, TGFB1
129.3COL11A2, INS, COL6A1, COL11A1
13
Show member pathways
9.3TIMP1, MMP3, TIMP2
149.2COL9A3, COL9A2, COL9A1, ACAN, TGFB1
15
Show member pathways
9.1TIMP1, TIMP2, TGFB1, INS, BMP7
16
Show member pathways
9.1TGFB1, TIMP1, BMP7, INS, TIMP2
17
Show member pathways
9.1INS, TIMP1, TGFB1, BMP7, TIMP2
18
Show member pathways
9.1ACAN, MMP3, TIMP2, TIMP1
19
Show member pathways
8.9COL6A1, COL9A1, COL9A3, COL9A2, TGFB1, INS
20
Show member pathways
8.8BMP7, MMP3, TGFB1, TIMP1, TIMP2
218.7COL9A1, COL9A3, COL11A1, COL9A2, COL6A1, COL11A2
22
Show member pathways
8.2MMP3, COL11A2, COL6A1, COL9A1, COL9A3, COL11A1
23
Show member pathways
8.2COL9A2, COL9A1, CALCA, COL9A3, COL6A1, MMP3
24
Show member pathways
8.0COL9A1, COL11A1, COL9A3, MMP3, COL11A2, COL6A1
25
Show member pathways
7.5TIMP2, TGFB1, TIMP1, COL9A1, COL9A3, COL11A1
26
Show member pathways
7.5BMP7, TGFB1, TIMP1, TIMP2, COL11A2, COL6A1
27
Show member pathways
6.8COL9A1, TIMP1, TIMP2, TGFB1, ACAN, BMP7

Compounds for genes affiliated with Spinal Stenosis

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Compounds related to Spinal Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1calcium gluconate4410.2INS, CALCA
2safranin o4410.0MMP3, BMP7, ACAN
3methyl selenol449.9TIMP1, TIMP2
4sorbinil44 1110.9TIMP2, TIMP1
5thiazide449.9CALCA, INS, VDR
6rhein449.8TIMP1, TGFB1
7agarose449.8BMP7, TIMP2, ACAN, TGFB1
8pyridinoline449.8MMP3, CALCA, TIMP1
9hydroxyproline44 24 1111.7TGFB1, TIMP2, TIMP1, CALCA
10streptozotocin449.7TIMP1, INS, TGFB1
11latanoprost44 1110.7TIMP2, MMP3, TIMP1
12(4-aminophenyl)mercuric acetate449.7MMP3, TIMP2, TIMP1
13deoxypyridinoline449.6VDR, MMP3, CALCA
14beta-ionone449.6TIMP2, TIMP1
15hydroxamate449.6TIMP1, MMP3, TIMP2
16thyroxine44 2410.6INS, VDR, CALCA, TGFB1
17propionate449.6TIMP1, TIMP2, MMP3
18procollagen449.6ACAN, TGFB1, MMP3, TIMP1
191,10-phenanthroline44 210.5TIMP2, MMP3, TIMP1
20batimastat44 61 1111.5MMP3, TIMP1, TIMP2
21etidronic acid44 50 1111.5CALCA, VDR
22alginate449.4ACAN, MMP3, TGFB1, BMP7, TIMP1
23tgf beta1449.4BMP7, TGFB1, ACAN, TIMP1, MMP3
24troglitazone44 28 61 1112.4VDR, INS, MMP3, TGFB1
25cytochalasin d44 6110.4TIMP2, MMP3, TIMP1, TGFB1
26calcitriol44 61 24 1112.3VDR, CALCA, BMP7, TGFB1, TIMP1
27glycosaminoglycan449.3TIMP2, ACAN, MMP3, TGFB1, TIMP1
28hyaluronic acid44 2410.3ACAN, TIMP2, MMP3, TGFB1, TIMP1
29ribonucleic acid449.2TIMP2, BMP7, MMP3, TIMP1, TGFB1
30pd 98,059449.2MMP3, ACAN, TGFB1, TIMP1, TIMP2
31glyceraldehyde 3-phosphate449.2ACAN, TIMP2, TIMP1, MMP3
32tacrolimus44 50 1111.2INS, TIMP2, TIMP1, VDR, TGFB1
33ascorbic acid44 2410.1ACAN, BMP7, MMP3, TIMP2, VDR
34methotrexate50 44 1111.0MMP3, TIMP2, TGFB1, TIMP1
35lactate449.0CALCA, MMP3, TIMP1, TIMP2, TGFB1, INS
36alendronate44 50 1111.0TIMP2, TIMP1, MMP3, CALCA, VDR
37vegf448.9CALCA, MMP3, TGFB1, TIMP1, TIMP2, BMP7
38glutamine448.9VDR, COL9A2, MMP3, TGFB1, TIMP1
39butyrate448.9TGFB1, TIMP1, TIMP2, VDR, MMP3
40sb 20358044 619.8VDR, ACAN, TIMP2, TIMP1, TGFB1, MMP3
41creatinine448.7INS, TGFB1, MMP3, BMP7, CALCA, VDR
42cyclosporin a44 28 6110.7VDR, TIMP2, TIMP1, TGFB1, MMP3, CALCA
43glutamate448.7INS, VDR, TIMP1, MMP3, ACAN, CALCA
44cycloheximide448.7BMP7, TIMP1, VDR, MMP3, TGFB1, TIMP2
45vitamin d448.7TGFB1, MMP3, CALCA, VDR, ACAN, BMP7
46dexamethasone44 50 28 1111.6VDR, TIMP1, BMP7, TGFB1, ACAN, MMP3
47alanine448.5INS, TGFB1, VDR, TIMP2, TIMP1, MMP3
48retinoic acid44 249.5BMP7, ACAN, TGFB1, TIMP1, VDR, TIMP2
49pge2448.4CALCA, BMP7, MMP3, ACAN, TIMP2, TIMP1
50estrogen448.3TIMP1, MMP3, INS, VDR, TIMP2, BMP7

GO Terms for genes affiliated with Spinal Stenosis

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Cellular components related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type XIGO:0055929.8COL11A1, COL11A2
2extracellular matrixGO:0310129.7COL6A1, BMP7, ACAN
3collagen type IXGO:0055949.7COL9A1, COL9A3, COL9A2
4Golgi lumenGO:0057969.5INS, TGFB1, ACAN
5extracellular spaceGO:0056158.7MMP3, CALCA, BMP7, INS, TIMP2, TGFB1
6endoplasmic reticulum lumenGO:0057888.6COL9A3, COL11A1, COL9A2, COL6A1, COL11A2, INS
7extracellular regionGO:0055765.7CALCA, INS, TIMP2, TIMP1, DCD, TGFB1

Biological processes related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:03328010.2BMP7, TGFB1
2positive regulation of cellular protein metabolic processGO:03227010.2TGFB1, INS
3positive regulation of peptidyl-threonine phosphorylationGO:01080010.2BMP7, TGFB1
4negative regulation of ossificationGO:03027910.2TGFB1, CALCA
5positive regulation of adenylate cyclase activityGO:04576210.2CALCA, TIMP2
6positive regulation of vasodilationGO:04590910.1CALCA, INS
7negative regulation of mitotic cell cycleGO:04593010.0TGFB1, TIMP2
8negative regulation of proteolysisGO:0458619.9INS, TIMP2
9positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.8TGFB1, BMP7
10agingGO:0075689.6TIMP2, TIMP1, CALCA, TGFB1
11axon guidanceGO:0074119.4COL6A1, COL9A3, COL9A2, BMP7, COL9A1
12skeletal system developmentGO:0015019.3COL11A2, BMP7, ACAN, VDR, COL9A2
13negative regulation of transcription, DNA-templatedGO:0458929.2BMP7, TGFB1, VDR, CALCA
14collagen catabolic processGO:0305748.5MMP3, COL11A2, COL6A1, COL9A2, COL9A1, COL11A1
15extracellular matrix disassemblyGO:0226177.6COL11A1, COL9A2, COL6A1, COL11A2, ACAN, MMP3
16extracellular matrix organizationGO:0301987.1TGFB1, COL9A1, COL9A3, COL11A1, COL9A2, TIMP1

Molecular functions related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.4TIMP2, TIMP1
2extracellular matrix structural constituent conferring tensile strengthGO:0300209.3COL11A2, COL9A2, COL9A3, COL9A1
3protein bindingGO:0055157.6VDR, INS, TIMP2, TIMP1, TGFB1, TSSK4

Products for genes affiliated with Spinal Stenosis

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  • Antibodies
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Sources for Spinal Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet