Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 38 12 52 41 42 14
Spinal Stenosis of Lumbar Region 12 69
Spinal Stenosis in Cervical Region 69
Cervical Spinal Stenosis 12
Lumbar Spinal Stenosis 12

Classifications:



Summaries for Spinal Stenosis

MedlinePlus : 41 your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to central cord syndrome and osteochondrosis, and has symptoms including neck pain, torticollis and back pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Betamethasone and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are Increased gamma-H2AX phosphorylation and limbs/digits/tail

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located in spinal cord.

Wikipedia : 72 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 central cord syndrome 29.0 COL9A2 COL9A3 THBS2
2 osteochondrosis 28.8 ACAN COL9A1 MMP3 TIMP1
3 spondylolisthesis 24.3 ACAN BMP7 CALCA COL11A2 COL1A2 COL9A1
4 cauda equina syndrome 11.1
5 hypochondroplasia 11.1
6 foot drop 11.1
7 acrodysostosis 2, with or without hormone resistance 10.9
8 spinal disease 10.7
9 spinal cord disease 10.7
10 chromosome 20 trisomy 10.7
11 childhood endodermal sinus tumor 10.5 MMP3 TIMP2
12 immunodeficiency 27b, mycobacteriosis, ad 10.5 MMP3 TIMP1
13 spindle epithelial tumor with thymus-like differentiation tumor 10.4 TIMP1 TIMP2
14 ulnar neuropathy 10.4 TIMP1 TIMP2
15 colon squamous cell carcinoma 10.3 TIMP1 TIMP2
16 keloids 10.3 MMP3 TIMP1
17 breast mucinous carcinoma 10.3 TIMP1 TIMP2
18 gait apraxia 10.2 MMP3 TIMP1 TIMP2
19 charcot-marie-tooth disease, axonal, type 2cc 10.2 MMP3 TIMP1 TIMP2
20 west syndrome 10.2 MMP3 TIMP1
21 systemic mastocytosis 10.2 BMP7 MMP3
22 pancreatic acth hormone producing tumor 10.2 MMP3 TIMP1 TIMP2
23 cervicitis 10.2
24 inappropriate adh syndrome 10.2 MMP3 TIMP1 TIMP2
25 impetigo 10.2 MMP3 TIMP1 TIMP2
26 mesenchymal cell neoplasm 10.2 ACAN MMP3 TIMP1
27 back pain 10.1
28 rare endometriosis 10.1 TIMP1 TIMP2
29 benign familial mesial temporal lobe epilepsy 10.1 COL9A1 COL9A2 COL9A3
30 dysmorphism-short stature-deafness-disorder of sex development syndrome 10.1 COL9A1 COL9A2 COL9A3
31 tricuspid valve prolapse 10.1 BMP7 CALCA TIMP1
32 radiculopathy 10.1
33 laryngomalacia 10.0 COL11A2 COL9A1
34 intermittent claudication 10.0
35 slc6a4-related altered drug metabolism 10.0 ACAN COL1A2
36 osteoarthritis 9.9
37 achondroplasia 9.9
38 scoliosis 9.9
39 mastoiditis 9.9 TIMP1 TIMP2
40 dengue hemorrhagic fever 9.9 ACAN CALCA COL9A3 MMP3
41 hyperostosis 9.8
42 quadriplegia 9.8
43 epiphyseal dysplasia, multiple, 1 9.7 ACAN COL9A1 COL9A2 COL9A3
44 peripheral artery disease 9.7
45 paraplegia 9.7
46 spondylosis 9.7
47 renal osteodystrophy 9.7
48 artery disease 9.7
49 epileptic encephalopathy, early infantile, 7 9.7 COL9A2 COL9A3 THBS2
50 diffuse idiopathic skeletal hyperostosis 9.6

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to Spinal Stenosis

Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:


neck pain, torticollis, back pain, low back pain, sciatica

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.1 CALCA COL11A2 COL1A2 COL9A1 COL9A2 COL9A3

MGI Mouse Phenotypes related to Spinal Stenosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.43 BMP7 COL1A2 COL9A1 COL9A2 THBS2 TIMP1
2 skeleton MP:0005390 9.23 BMP7 COL11A2 COL1A2 COL9A1 COL9A2 MMP3

Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 197)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4,Early Phase 1 378-44-9 9782
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Lidocaine Approved, Vet_approved Phase 4,Early Phase 1 137-58-6 3676
4
Methylprednisolone Approved, Vet_approved Phase 4,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Early Phase 1 50-24-8 5755
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Diphenhydramine Approved Phase 4 58-73-1, 147-24-0 3100
10
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
11
Promethazine Approved Phase 4 60-87-7 4927
12
Menthol Approved Phase 4 2216-51-5 16666
13
Nicardipine Approved Phase 4 55985-32-5 4474
14
Remifentanil Approved Phase 4 132875-61-7 60815
15
Tranexamic Acid Approved Phase 4 1197-18-8 5526
16
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Early Phase 1 437-38-7 3345
19
Gabapentin Approved, Investigational Phase 4,Early Phase 1 60142-96-3 3446
20
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
21
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
22
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
23
Acetaminophen Approved Phase 4,Early Phase 1 103-90-2 1983
24
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
25
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
26
gamma-Aminobutyric acid Investigational Phase 4,Early Phase 1 56-12-2 119
27 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Early Phase 1
28 Analgesics Phase 4,Phase 2,Phase 3,Early Phase 1
29 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Early Phase 1
30 Anesthetics Phase 4,Phase 2,Phase 3,Early Phase 1
31 Anesthetics, Local Phase 4,Early Phase 1
32 Anti-Arrhythmia Agents Phase 4
33 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
34 Antiemetics Phase 4,Early Phase 1
35 Anti-Inflammatory Agents Phase 4,Early Phase 1
36 Antineoplastic Agents, Hormonal Phase 4,Early Phase 1
37 Autonomic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
38 BB 1101 Phase 4
39 Betamethasone benzoate Phase 4,Early Phase 1
40 Betamethasone sodium phosphate Phase 4,Early Phase 1
41 Betamethasone Valerate Phase 4,Early Phase 1 2152-44-5
42 Betamethasone-17,21-dipropionate Phase 4,Early Phase 1
43 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Early Phase 1
44 Dexamethasone acetate Phase 4 1177-87-3
45 Diuretics, Potassium Sparing Phase 4
46 Gastrointestinal Agents Phase 4,Early Phase 1
47 glucocorticoids Phase 4,Early Phase 1
48 HIV Protease Inhibitors Phase 4
49 Hormone Antagonists Phase 4,Early Phase 1
50 Hormones Phase 4,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 212)

id Name Status NCT ID Phase Drugs
1 Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial) Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
2 Long-Term Outcomes for Lumbar Spinal Stenosis Patients Treated With X STOP® Completed NCT00534092 Phase 4
3 A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
4 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
5 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
6 Intermittent Neurogenic Claudication Treatment With APERIUS® Completed NCT00887744 Phase 4
7 Lumbar Stenosis Outcomes Research (LUSTOR) Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
8 Neurogenic Intermittent Claudication Evaluation Study Completed NCT00905359 Phase 4
9 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
10 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
11 Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
12 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study Completed NCT02895555 Phase 4
13 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
14 Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
15 Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
16 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
17 Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
18 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
19 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
20 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Intravenous infusion of Dexmedetomidine or 0.9% Saline
21 The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery Completed NCT01053039 Phase 4 Intrathecal Morphine;Intrathecal Saline
22 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
23 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
24 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
25 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
26 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
27 Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? Active, not recruiting NCT02090244 Phase 4 Teriparatide
28 Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis Not yet recruiting NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
29 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
30 Condition of Approval Study Terminated NCT00517751 Phase 4
31 Lumbar Stenosis Outcomes Research II Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
32 Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant Terminated NCT01057641 Phase 4
33 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
34 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
35 Effects of X-STOP® Versus Laminectomy Study Withdrawn NCT00558129 Phase 4
36 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
37 Surgical Versus Nonsurgical Treatment for Spinal Stenosis Completed NCT00022776 Phase 3
38 Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
39 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
40 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
41 The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
42 Ephedrine and Phenylephrine for Spinal Hypotension Recruiting NCT03047109 Phase 2, Phase 3 Phenylephrine;Ephedrine
43 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis Active, not recruiting NCT01618435 Phase 3
44 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Not yet recruiting NCT02725723 Phase 2, Phase 3 epidural injection
45 A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis Terminated NCT00697827 Phase 3
46 DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion Terminated NCT00627497 Phase 3
47 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
48 INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine Terminated NCT01415908 Phase 3
49 Surgical Management of Spinal Cord Injuries In Neck Unknown status NCT00475748 Phase 2
50 Chiropractic Dosage for Lumbar Stenosis Completed NCT00527527 Phase 2

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Genetic Tests for Spinal Stenosis

Anatomical Context for Spinal Stenosis

MalaCards organs/tissues related to Spinal Stenosis:

39
Bone, Spinal Cord, Testes, Skin, Heart, Bone Marrow, Lung

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 713)
id Title Authors Year
1
Cochrane in CORR (Ar): Surgical Versus Non-surgical Treatment for Lumbar Spinal Stenosis. ( 28755156 )
2017
2
Five-year durability of stand-alone interspinous process decompression for lumbar spinal stenosis. ( 28919727 )
2017
3
Surgical management of lumbar spinal stenosis: a survey among Norwegian spine surgeons. ( 27848083 )
2017
4
Dural sac cross-sectional area and morphological grade show significant associations with patient-rated outcome of surgery for lumbar central spinal stenosis. ( 28856447 )
2017
5
Tandem Spinal Stenosis: A Systematic Review. ( 28872572 )
2017
6
Does the effectiveness of core stability exercises correlate with the severity of spinal stenosis in patients with lumbar spinal stenosis? ( 28811784 )
2017
7
The Influence of Single-level Versus Multilevel Decompression on the Outcome in Multisegmental Lumbar Spinal Stenosis: Analysis of the Lumbar Spinal Outcome Study (LSOS) Data. ( 28059949 )
2017
8
Survey of integrative lumbar spinal stenosis treatment in Korean medicine doctors: preliminary data for clinical practice guidelines. ( 28851418 )
2017
9
Depression is associated with the long-term outcome of lumbar spinal stenosis surgery: a 10-year follow-up study. ( 28822826 )
2017
10
Understanding the value of minimally invasive procedures for the treatment of lumbar spinal stenosis: the case of interspinous spacer devices. ( 28847740 )
2017
11
Preoperative sense of coherence associated with the 10-year outcomes of lumbar spinal stenosis surgery. ( 28810389 )
2017
12
Preliminary Results of Relationship between Preoperative Walking Ability and Magnetic Resonance Imaging Morphology in Patients with Lumbar Canal Stenosis: Comparison between Trefoil and Triangle Types of Spinal Stenosis. ( 28874976 )
2017
13
Nursing Review Section of Surgical Neurology International Part 2: Lumbar Spinal Stenosis. ( 28781916 )
2017
14
Patients' experience with non-surgical treatment for lumbar spinal stenosis: a qualitative study. ( 28870836 )
2017
15
The role of epidural contrast distribution in predicting the effectiveness of steroid and local anesthetic injection in patients with lumbar spinal stenosis. ( 28759948 )
2017
16
Surgeries for Patients with Tandem Spinal Stenosis in Cervical andThoracic Spine: Combined or Staged Surgeries? ( 28765029 )
2017
17
Lumbar Spinal Muscles and Spinal Canal Study by MRI Three-Dimensional Reconstruction in Adult Lumbar Spinal Stenosis. ( 28087395 )
2017
18
Comparison of postoperative clinical outcome after repairing surgery for lumbar spinal stenosis between diabetic and nondiabetic patients. ( 28761519 )
2017
19
Dural ectasia associated with Mounier-Kuhn syndrome: a novel association in the context of spinal stenosis. ( 28855219 )
2017
20
The sagittal spinal profile type: a principal precondition for surgical decision making in patients with lumbar spinal stenosis. ( 28862573 )
2017
21
Persistent cauda equina syndrome after caudal epidural injection under severe spinal stenosis: a case report. ( 28652808 )
2017
22
Decompression Surgery Alone Versus Decompression Plus Fusion in Symptomatic Lumbar Spinal Stenosis: A Swiss Prospective Multi-center Cohort Study with 3 Years of Follow-up. ( 28092340 )
2017
23
Muscle gap approach under a minimally invasive channel technique for treating long segmental lumbar spinal stenosis: A retrospective study. ( 28796075 )
2017
24
Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )
2017
25
Suprapedicular Foraminal Endoscopic Approach to Lumbar Lateral Recess Decompression Surgery to Treat Degenerative Lumbar Spinal Stenosis. ( 27890911 )
2016
26
Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis. ( 27136214 )
2016
27
Enough positive rate of paraspinal mapping and diffusion tensor imaging with levels which should be decompressed in lumbar spinal stenosis. ( 27188929 )
2016
28
Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis. ( 27136217 )
2016
29
A potential method for identifying dural ossification by measuring the degree of spinal stenosis in thoracic ossification of ligamentum flavum. ( 27959285 )
2016
30
Fusion adds little value to decompression for lumbar spinal stenosis, studies show. ( 27081100 )
2016
31
Outcome after Surgery of Lumbar Spinal Stenosis: A Randomized Comparison of Bilateral Laminotomy, Trumpet Laminectomy, and Conventional Laminectomy. ( 27092304 )
2016
32
Multifidus Degeneration, a New Risk Factor for Lumbar Spinal Stenosis: A Case-Control Study. ( 27931946 )
2016
33
Diabetes Mellitus, a New Risk Factor for Lumbar Spinal Stenosis: A Case-Control Study. ( 27168730 )
2016
34
Effect of TENS Versus Placebo on Walking Capacity in Patients With Lumbar Spinal Stenosis: A Protocol for a Randomized Controlled Trial. ( 27660596 )
2016
35
Microsurgical unilateral laminotomy for decompression of lumbar spinal stenosis: long-term results and predictive factors. ( 27084380 )
2016
36
Lumbar spondylosis, lumbar spinal stenosis, knee pain, back muscle strength are associated with the locomotive syndrome: Rural population study in Japan. ( 27021251 )
2016
37
Minimally invasive surgery for lumbar spinal stenosis. ( 27659170 )
2016
38
Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis. ( 27136218 )
2016
39
Psychosocial Factors in Patients Indicated for Lumbar Spinal Stenosis Surgery. ( 27144540 )
2016
40
Cost-effectiveness of conservative versus surgical treatment strategies of lumbar spinal stenosis in the Swiss setting: analysis of the prospective multicenter Lumbar Stenosis Outcome Study (LSOS). ( 28040872 )
2016
41
Surgery for Lumbar Spinal Stenosis in Individuals Aged 80 and Older: A Multicenter Observational Study. ( 27611928 )
2016
42
Persistent Symptoms After Anatomically Successful Surgery for Lumbar Spinal Stenosis. ( 27080753 )
2016
43
The effect of incidental dural lesions on outcome after decompression surgery for lumbar spinal stenosis: results of a multi-center study with 800 patients. ( 27125375 )
2016
44
Eidurographic Findings Following Percutaneous Epidural Adhesiolysis Failed to Correlate with Level of Pain Reduction in Patients with Lumbar Spinal Stenosis. ( 27651508 )
2016
45
Clinical and Radiological Study Focused on Relief of low Back Pain Following Decompression Surgery in Selected Patients of Lumbar Spinal Stenosis Associated with Grade I Degenerative Spondylolisthesis. ( 27488289 )
2016
46
Degenerative lumbar spinal stenosis and physical functioning: an exploration of associations between self-reported measures and physical performance tests. ( 27846739 )
2016
47
Clinical outcome of lumbar spinal stenosis based on new classification according to hypertrophied ligamentum flavum. ( 27580526 )
2016
48
Patient Priority Weighting of the Roland Morris Disability Questionnaire Does Not Change Results of the Lumbar Epidural Steroid Injections for Spinal Stenosis Trial. ( 27105466 )
2016
49
The effectiveness of decompression alone compared with additional fusion for lumbar spinal stenosis with degenerative spondylolisthesis: a pragmatic comparative non-inferiority observational study from the Norwegian Registry for Spine Surgery. ( 27421276 )
2016
50
Surgical Versus Non-Surgical Treatment for Lumbar Spinal Stenosis. ( 27128388 )
2016

Variations for Spinal Stenosis

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 ACAN BMP7 COL11A2 COL1A2 COL9A1 COL9A2
2
Show member pathways
13.19 ACAN COL11A2 COL1A2 COL9A1 COL9A2 COL9A3
3
Show member pathways
12.68 COL11A2 COL1A2 COL9A1 COL9A2 COL9A3 THBS2
4
Show member pathways
12.57 COL11A2 COL1A2 COL9A1 COL9A2 COL9A3 MMP3
5
Show member pathways
12.5 ACAN BMP7 COL11A2 COL1A2 COL9A1 COL9A2
6 12.48 COL1A2 COL9A1 COL9A2 COL9A3 THBS2
7
Show member pathways
11.98 ACAN BMP7 COL11A2 COL1A2 COL9A1 COL9A2
8 11.79 COL1A2 MMP3 TIMP1
9
Show member pathways
11.73 COL1A2 COL9A1 COL9A2 COL9A3 THBS2
10
Show member pathways
11.7 MMP3 THBS2 TIMP1 TIMP2
11 11.65 MMP3 TIMP1 TIMP2
12 11.5 BMP7 CALCA TIMP1
13 11.41 COL1A2 MMP3 TIMP1 TIMP2
14 11.31 ACAN COL9A1 COL9A2 COL9A3
15 11.24 ACAN MMP3 TIMP2
16 11.22 COL1A2 THBS2
17 11.2 COL9A1 COL9A2 COL9A3
18 11.09 COL9A1 COL9A3
19 10.97 TIMP1 TIMP2

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.85 COL11A2 COL1A2 COL9A1 COL9A2 COL9A3 TIMP1
2 extracellular matrix GO:0031012 9.8 ACAN BMP7 COL1A2 MMP3 THBS2 TIMP1
3 extracellular region GO:0005576 9.73 ACAN BMP7 CALCA COL11A2 COL1A2 COL9A1
4 collagen trimer GO:0005581 9.63 COL11A2 COL1A2 COL9A1 COL9A2 COL9A3 TIMP1
5 basement membrane GO:0005604 9.61 ACAN THBS2 TIMP1
6 collagen type IX trimer GO:0005594 9.5 COL9A1 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.32 ACAN COL11A2 COL1A2 COL9A1 COL9A2 COL9A3
8 extracellular space GO:0005615 10.01 ACAN BMP7 CALCA COL1A2 MMP3 THBS2

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.65 CALCA TIMP1 TIMP2
2 cartilage development GO:0051216 9.61 BMP7 COL11A2 TIMP1
3 collagen catabolic process GO:0030574 9.54 COL11A2 COL1A2 MMP3
4 positive regulation of adenylate cyclase activity GO:0045762 9.46 CALCA TIMP2
5 extracellular matrix disassembly GO:0022617 9.46 ACAN MMP3 TIMP1 TIMP2
6 collagen fibril organization GO:0030199 9.43 ACAN COL11A2 COL1A2
7 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.4 TIMP1 TIMP2
8 extracellular matrix organization GO:0030198 9.35 ACAN COL1A2 COL9A1 COL9A2 COL9A3
9 negative regulation of metallopeptidase activity GO:1905049 9.32 TIMP1 TIMP2
10 skeletal system development GO:0001501 9.02 ACAN BMP7 COL11A2 COL1A2 COL9A2

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 COL1A2 TIMP1 TIMP2
2 enzyme inhibitor activity GO:0004857 9.32 TIMP1 TIMP2
3 metalloendopeptidase inhibitor activity GO:0008191 9.26 TIMP1 TIMP2
4 extracellular matrix structural constituent GO:0005201 9.13 ACAN COL11A2 COL1A2
5 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.92 COL11A2 COL9A1 COL9A2 COL9A3

Sources for Spinal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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