Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 37 12 36 51 40 41 14
Spinal Stenosis of Lumbar Region 12 69
Cervical Spinal Stenosis 12 72
Lumbar Spinal Stenosis 12 72
Spinal Stenosis in Cervical Region 69

Classifications:



Summaries for Spinal Stenosis

MedlinePlus : 40 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and back pain, and has symptoms including sciatica, low back pain and back pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Betamethasone and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and spinal cord, and related phenotypes are hearing/vestibular/ear and limbs/digits/tail

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located in spinal cord.

Wikipedia : 72 Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 30.7 BMP7 MMP3
2 back pain 30.0 COL9A2 COL9A3 THBS2
3 osteoarthritis 28.6 ACAN COL11A2 COL2A1 COL9A1 MMP3 TIMP1
4 congenital cervical spinal stenosis 12.1
5 achondroplasia 11.2
6 cauda equina syndrome 11.2
7 hypochondroplasia 11.2
8 foot drop 11.2
9 acrodysostosis 2 with or without hormone resistance 11.0
10 spinal disease 10.9
11 spinal cord disease 10.9
12 chromosome 20 trisomy 10.9
13 gingival hypertrophy 10.4 MMP3 TIMP2
14 episodic pain syndrome, familial, 1 10.4
15 microcystic meningioma 10.3 TIMP1 TIMP2
16 cervicitis 10.3
17 nasal cavity squamous cell carcinoma 10.3 TIMP1 TIMP2
18 joint disorders 10.2 MMP3 TIMP1
19 dental fluorosis 10.2 COL1A2 TIMP1
20 squamous cell carcinoma of the hypopharynx 10.2 MMP3 TIMP1 TIMP2
21 conjunctivochalasis 10.2 MMP3 TIMP1 TIMP2
22 sorsby fundus dystrophy 10.2 MMP3 TIMP1 TIMP2
23 varicose veins 10.2 MMP3 TIMP1 TIMP2
24 aortic aneurysm, familial abdominal, 1 10.2 MMP3 TIMP1 TIMP2
25 periodontal disease 10.2 MMP3 TIMP1 TIMP2
26 tendinosis 10.2 MMP3 TIMP1
27 vitreoretinal degeneration 10.2 COL2A1 COL9A2
28 fundus dystrophy 10.2 MMP3 TIMP1 TIMP2
29 fibrosarcoma 10.2 MMP3 TIMP1 TIMP2
30 achondrogenesis 10.2 COL2A1 COL9A2
31 achondrogenesis, type ia 10.1 ACAN COL2A1
32 scheuermann disease 10.1 COL2A1 COL9A3
33 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.1 COL9A1 COL9A2 COL9A3
34 radiculopathy 10.1
35 appendix adenocarcinoma 10.1 TIMP1 TIMP2
36 autosomal recessive stickler syndrome 10.1 COL9A1 COL9A2 COL9A3
37 cartilage disease 10.1 ACAN COL2A1
38 peroneal nerve paralysis 10.1 CALCA COL2A1
39 spondyloepiphyseal dysplasia with congenital joint dislocations 10.1 ACAN COL2A1
40 diffuse pulmonary fibrosis 10.1 BMP7 CALCA TIMP1
41 metaphyseal chondrodysplasia, jansen type 10.1 CALCA COL2A1
42 macroglossia 10.1 COL2A1 COL9A1
43 achondrogenesis, type ii 10.1 ACAN COL2A1
44 aging 10.0
45 intermittent claudication 10.0
46 hypochondrogenesis 10.0 ACAN COL2A1
47 otospondylomegaepiphyseal dysplasia, autosomal recessive 10.0 COL11A2 COL2A1
48 osteoarthritis with mild chondrodysplasia 10.0
49 otospondylomegaepiphyseal dysplasia, autosomal dominant 10.0 COL11A2 COL2A1
50 otospondylomegaepiphyseal dysplasia 10.0 COL11A2 COL2A1

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to Spinal Stenosis

Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:


sciatica, low back pain, back pain, torticollis, neck pain

MGI Mouse Phenotypes related to Spinal Stenosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.55 COL9A2 BMP7 COL11A2 COL2A1 COL9A1
2 limbs/digits/tail MP:0005371 9.5 BMP7 COL1A2 COL2A1 COL9A1 COL9A2 THBS2
3 skeleton MP:0005390 9.28 BMP7 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4,Early Phase 1 378-44-9 9782
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Lidocaine Approved, Vet_approved Phase 4,Early Phase 1 137-58-6 3676
4
Methylprednisolone Approved, Vet_approved Phase 4,Early Phase 1 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Early Phase 1 50-24-8 5755
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
10
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
11
Promethazine Approved, Investigational Phase 4 60-87-7 4927
12
Menthol Approved Phase 4 2216-51-5 16666
13
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
14
Remifentanil Approved Phase 4 132875-61-7 60815
15
Tranexamic Acid Approved Phase 4 1197-18-8 5526
16
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Early Phase 1 437-38-7 3345
19
Gabapentin Approved, Investigational Phase 4,Early Phase 1 60142-96-3 3446
20
gamma-Aminobutyric acid Approved, Investigational Phase 4,Early Phase 1 56-12-2 119
21
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
22
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
23
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
24
Acetaminophen Approved Phase 4,Early Phase 1 103-90-2 1983
25
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
26
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
27
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
28 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Early Phase 1
29 Analgesics Phase 4,Phase 2,Phase 3,Early Phase 1
30 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Early Phase 1
31 Anesthetics Phase 4,Phase 2,Phase 3,Early Phase 1
32 Anesthetics, Local Phase 4,Early Phase 1
33 Anti-Arrhythmia Agents Phase 4
34 Anti-Asthmatic Agents Phase 4,Early Phase 1
35 Antiemetics Phase 4,Early Phase 1
36 Anti-Inflammatory Agents Phase 4,Early Phase 1
37 Antineoplastic Agents, Hormonal Phase 4,Early Phase 1
38 Autonomic Agents Phase 4,Early Phase 1
39 BB 1101 Phase 4
40 Betamethasone benzoate Phase 4,Early Phase 1
41 Betamethasone sodium phosphate Phase 4,Early Phase 1
42 Betamethasone Valerate Phase 4,Early Phase 1 2152-44-5
43 Betamethasone-17,21-dipropionate Phase 4,Early Phase 1
44 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Early Phase 1
45 Dexamethasone acetate Phase 4 1177-87-3
46 Diuretics, Potassium Sparing Phase 4
47 Gastrointestinal Agents Phase 4,Early Phase 1
48 glucocorticoids Phase 4,Early Phase 1
49 HIV Protease Inhibitors Phase 4
50 Hormone Antagonists Phase 4,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 213)

# Name Status NCT ID Phase Drugs
1 Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial) Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
2 A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
3 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
4 Intermittent Neurogenic Claudication Treatment With APERIUS® Completed NCT00887744 Phase 4
5 Lumbar Stenosis Outcomes Research (LUSTOR) Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
6 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
7 Neurogenic Intermittent Claudication Evaluation Study Completed NCT00905359 Phase 4
8 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
9 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
10 Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
11 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study Completed NCT02895555 Phase 4
12 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
13 Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
14 Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
15 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
16 Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
17 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
18 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
19 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Intravenous infusion of Dexmedetomidine or 0.9% Saline
20 The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery Completed NCT01053039 Phase 4 Intrathecal Morphine;Intrathecal Saline
21 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
22 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
23 Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis Recruiting NCT01455805 Phase 4
24 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
25 BIO4 Clinical Case Study: Cervical Spine Recruiting NCT03077204 Phase 4
26 Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? Active, not recruiting NCT02090244 Phase 4 Teriparatide
27 Efficacy of Using Solum IV and BMC With GFC in TLIF Not yet recruiting NCT03223701 Phase 4
28 Condition of Approval Study Terminated NCT00517751 Phase 4
29 Lumbar Stenosis Outcomes Research II Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
30 Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant Terminated NCT01057641 Phase 4
31 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
32 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
33 Effects of X-STOP® Versus Laminectomy Study Withdrawn NCT00558129 Phase 4
34 Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
35 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Unknown status NCT02725723 Phase 2, Phase 3 epidural injection
36 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
37 Surgical Versus Nonsurgical Treatment for Spinal Stenosis Completed NCT00022776 Phase 3
38 Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
39 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
40 The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
41 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
42 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis Active, not recruiting NCT01618435 Phase 3
43 A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis Terminated NCT00697827 Phase 3
44 DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion Terminated NCT00627497 Phase 3
45 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
46 INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine Terminated NCT01415908 Phase 3
47 Surgical Management of Spinal Cord Injuries In Neck Unknown status NCT00475748 Phase 2
48 Chiropractic Dosage for Lumbar Stenosis Completed NCT00527527 Phase 2
49 Cognitive-Behavioral Physical Therapy Completed NCT01131611 Phase 1, Phase 2
50 Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion Completed NCT01106417 Phase 2

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Genetic Tests for Spinal Stenosis

Anatomical Context for Spinal Stenosis

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

18
Spinal Cord

MalaCards organs/tissues related to Spinal Stenosis:

38
Bone, Spinal Cord, Testes, Skin, Bone Marrow, Heart, Lung

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 738)
# Title Authors Year
1
Transforaminal endoscopic decompression for thoracic spinal stenosis under local anesthesia. ( 29353327 )
2018
2
Diagnosis of Lumbar Spinal Stenosis with Functional Myelography. ( 29346832 )
2018
3
A Rare Case of Thoracic Spinal Stenosis in a White Male. ( 29315102 )
2018
4
Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )
2018
5
Effectiveness of dynamic fixation Coflex treatment for degenerative lumbar spinal stenosis. ( 29399069 )
2018
6
Outcome of Transforaminal Epidural Steroid Injection According to the Severity of Lumbar Foraminal Spinal Stenosis. ( 29357335 )
2018
7
Risk factors & associated complications for postoperative urinary retention after lumbar surgery for lumbar spinal stenosis. ( 29447854 )
2018
8
Cervical spine surgery for tandem spinal stenosis: The impact on low back pain. ( 29408772 )
2018
9
Judicious and Vigilant Use of Electronically Based Treatment Enhancements and Subjective Patient-Reported Outcomes: Commentary on an article by Richard L. Skolasky, ScD, et al.: "Telephone-Based Intervention to Improve Rehabilitation Engagement After Spinal Stenosis Surgery. A Prospective Lagged Controlled Trial". ( 29298269 )
2018
10
Lumbar Intraspinal Spindle Cell Rhabdomyosarcoma as a Rare Cause of Spinal Stenosis: A Case Report. ( 29452297 )
2018
11
Decompressive surgery for lumbar spinal stenosis across the Atlantic: a comparison of preoperative MRI between matched cohorts from the US and Norway. ( 29350291 )
2018
12
A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study). ( 29351748 )
2018
13
Bilateral decompression and intervertebral fusion via unilateral fenestration for complex lumbar spinal stenosis with a mobile microendoscopic technique. ( 29369203 )
2018
14
Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis. ( 29391028 )
2018
15
Systemic effects of epidural steroid injections for spinal stenosis. ( 29394207 )
2018
16
Incidence of spinal epidural lipomatosis in patients with spinal stenosis. ( 29203971 )
2018
17
Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review. ( 29357326 )
2018
18
Unilateral repetitive tibial nerve stimulation improves neurogenic claudication and bilateral F-wave conduction in central lumbar spinal stenosis. ( 29352625 )
2018
19
A comparative study of 2-year follow-up outcomes in lumbar spinal stenosis patients treated with physical therapy alone and those with surgical intervention after less successful physical therapy. ( 29395806 )
2018
20
Does the effectiveness of core stability exercises correlate with the severity of spinal stenosis in patients with lumbar spinal stenosis? ( 28811784 )
2017
21
Progress in Intraoperative Neurophysiological Monitoring for the Surgical Treatment of Thoracic Spinal Stenosis. ( 29301602 )
2017
22
Understanding the value of minimally invasive procedures for the treatment of lumbar spinal stenosis: the case of interspinous spacer devices. ( 28847740 )
2017
23
Dural ectasia associated with Mounier-Kuhn syndrome: a novel association in the context of spinal stenosis. ( 28855219 )
2017
24
Cochrane in CORR (Ar): Surgical Versus Non-surgical Treatment for Lumbar Spinal Stenosis. ( 28755156 )
2017
25
Comparison of postoperative clinical outcome after repairing surgery for lumbar spinal stenosis between diabetic and nondiabetic patients. ( 28761519 )
2017
26
Depression is associated with the long-term outcome of lumbar spinal stenosis surgery: a 10-year follow-up study. ( 28822826 )
2017
27
The role of epidural contrast distribution in predicting the effectiveness of steroid and local anesthetic injection in patients with lumbar spinal stenosis. ( 28759948 )
2017
28
Dural sac cross-sectional area and morphological grade show significant associations with patient-rated outcome of surgery for lumbar central spinal stenosis. ( 28856447 )
2017
29
Preliminary Results of Relationship between Preoperative Walking Ability and Magnetic Resonance Imaging Morphology in Patients with Lumbar Canal Stenosis: Comparison between Trefoil and Triangle Types of Spinal Stenosis. ( 28874976 )
2017
30
Persistent cauda equina syndrome after caudal epidural injection under severe spinal stenosis: a case report. ( 28652808 )
2017
31
Surgical management of lumbar spinal stenosis: a survey among Norwegian spine surgeons. ( 27848083 )
2017
32
Survey of integrative lumbar spinal stenosis treatment in Korean medicine doctors: preliminary data for clinical practice guidelines. ( 28851418 )
2017
33
Nursing Review Section of Surgical Neurology International Part 2: Lumbar Spinal Stenosis. ( 28781916 )
2017
34
Cervicothoracic syringomyelia caused by cervical spinal stenosis: Case report and literature review. ( 29285404 )
2017
35
Surgeon Reliability for the Assessment of Lumbar Spinal Stenosis on MRI: The Impact of Surgeon Experience. ( 29372138 )
2017
36
The sagittal spinal profile type: a principal precondition for surgical decision making in patients with lumbar spinal stenosis. ( 28862573 )
2017
37
Patients' experience with non-surgical treatment for lumbar spinal stenosis: a qualitative study. ( 28870836 )
2017
38
Muscle gap approach under a minimally invasive channel technique for treating long segmental lumbar spinal stenosis: A retrospective study. ( 28796075 )
2017
39
Five-year durability of stand-alone interspinous process decompression for lumbar spinal stenosis. ( 28919727 )
2017
40
Surgeries for Patients with Tandem Spinal Stenosis in Cervical andThoracic Spine: Combined or Staged Surgeries? ( 28765029 )
2017
41
Tandem Spinal Stenosis: A Systematic Review. ( 28872572 )
2017
42
Lumbar Spinal Muscles and Spinal Canal Study by MRI Three-Dimensional Reconstruction in Adult Lumbar Spinal Stenosis. ( 28087395 )
2017
43
Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )
2017
44
The Influence of Single-level Versus Multilevel Decompression on the Outcome in Multisegmental Lumbar Spinal Stenosis: Analysis of the Lumbar Spinal Outcome Study (LSOS) Data. ( 28059949 )
2017
45
Decompression Surgery Alone Versus Decompression Plus Fusion in Symptomatic Lumbar Spinal Stenosis: A Swiss Prospective Multi-center Cohort Study with 3 Years of Follow-up. ( 28092340 )
2017
46
Preoperative sense of coherence associated with the 10-year outcomes of lumbar spinal stenosis surgery. ( 28810389 )
2017
47
In Patients with Lumbar Spinal Stenosis, Adding Fusion Surgery to Decompression Surgery Did Not Improve Outcomes at 2 Years. ( 27852913 )
2016
48
Efficacy of intraoperative direct electrical stimulation of the spinal root and measurement of distal motor latency in lumbar spinal stenosis. ( 27613011 )
2016
49
A potential method for identifying dural ossification by measuring the degree of spinal stenosis in thoracic ossification of ligamentum flavum. ( 27959285 )
2016
50
Response to comments on "Microsurgical decompression for central lumbar spinal stenosis: a single-center observational study". ( 27663879 )
2016

Variations for Spinal Stenosis

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
2
Show member pathways
13.17 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
3
Show member pathways
12.82 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3 THBS2
4
Show member pathways
12.77 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
5
Show member pathways
12.75 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
6
Show member pathways
12.67 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7
Show member pathways
12.02 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
8
Show member pathways
11.97 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3 THBS2
9
Show member pathways
11.96 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
10 11.83 COL1A2 MMP3 TIMP1
11
Show member pathways
11.81 MMP3 THBS2 TIMP1 TIMP2
12 11.78 BMP7 COL11A2 COL2A1
13 11.74 ACAN BMP7 COL2A1
14 11.7 MMP3 TIMP1 TIMP2
15 11.56 ACAN BMP7 COL2A1
16 11.55 ACAN COL9A1 COL9A2 COL9A3
17 11.55 COL1A2 COL2A1 MMP3 TIMP1 TIMP2
18 11.53 BMP7 CALCA TIMP1
19 11.31 ACAN MMP3 TIMP2
20 11.28 COL9A1 COL9A2 COL9A3
21 11.17 ACAN COL2A1
22 11.13 COL9A1 COL9A3
23 11 TIMP1 TIMP2
24 10.56 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 ACAN BMP7 CALCA COL11A2 COL1A2 COL2A1
2 endoplasmic reticulum lumen GO:0005788 9.87 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
3 extracellular matrix GO:0031012 9.86 ACAN BMP7 COL1A2 COL2A1 MMP3 THBS2
4 basement membrane GO:0005604 9.73 ACAN COL2A1 THBS2 TIMP1
5 collagen type IX trimer GO:0005594 9.54 COL9A1 COL9A2 COL9A3
6 collagen trimer GO:0005581 9.5 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7 proteinaceous extracellular matrix GO:0005578 9.36 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
8 extracellular space GO:0005615 10.06 ACAN BMP7 CALCA COL1A2 COL2A1 MMP3

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.7 CALCA TIMP1 TIMP2
2 central nervous system development GO:0007417 9.67 ACAN COL2A1 TIMP2
3 extracellular matrix disassembly GO:0022617 9.67 ACAN MMP3 TIMP1 TIMP2
4 cartilage development GO:0051216 9.62 BMP7 COL11A2 COL2A1 TIMP1
5 collagen catabolic process GO:0030574 9.56 COL11A2 COL1A2 COL2A1 MMP3
6 chondrocyte differentiation GO:0002062 9.55 COL11A2 COL2A1
7 cellular response to BMP stimulus GO:0071773 9.54 BMP7 COL2A1
8 tissue homeostasis GO:0001894 9.51 COL11A2 COL2A1
9 positive regulation of adenylate cyclase activity GO:0045762 9.48 CALCA TIMP2
10 embryonic skeletal joint morphogenesis GO:0060272 9.46 BMP7 COL2A1
11 collagen fibril organization GO:0030199 9.46 ACAN COL11A2 COL1A2 COL2A1
12 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.43 TIMP1 TIMP2
13 skeletal system development GO:0001501 9.43 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A2
14 negative regulation of metallopeptidase activity GO:1905049 9.4 TIMP1 TIMP2
15 extracellular matrix organization GO:0030198 9.17 ACAN COL1A2 COL2A1 COL9A1 COL9A2 COL9A3

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.97 ACAN COL11A2 COL1A2 COL2A1 COL9A1 MMP3
2 protease binding GO:0002020 9.43 COL1A2 TIMP1 TIMP2
3 enzyme inhibitor activity GO:0004857 9.4 TIMP1 TIMP2
4 metalloendopeptidase inhibitor activity GO:0008191 9.32 TIMP1 TIMP2
5 extracellular matrix structural constituent GO:0005201 9.26 ACAN COL11A2 COL1A2 COL2A1
6 platelet-derived growth factor binding GO:0048407 9.16 COL1A2 COL2A1
7 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.02 COL11A2 COL2A1 COL9A1 COL9A2 COL9A3

Sources for Spinal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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