MCID: SPN027
MIFTS: 62

Spinal Stenosis malady

Bone diseases, Neuronal diseases categories
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Summaries for Spinal Stenosis

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and renal osteodystrophy. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endochondral Ossification and RXR and RAR heterodimerization with other nuclear receptor. The compounds calcium gluconate and safranin o have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, spinal cord and bone, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Disease Ontology:8 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia:65 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Aliases & Classifications for Spinal Stenosis

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Neuronal diseases


Aliases & Descriptions:

spinal stenosis 8 10 45 34 31 62
spinal stenosis of lumbar region 8 62
spinal stenosis in cervical region 62
cervical spinal stenosis 8
lumbar spinal stenosis 8


Related Diseases for Spinal Stenosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis31.1TSSK4, BMP7, LSS
2renal osteodystrophy30.3VDR, BMP7, CALCA
3spondylosis30.3TSSK4, COL6A1
4osteoarthritis30.1COL9A3, COL9A1, COL9A2, TGFB1, VDR, TIMP1
5hypertension30.0INS, TGFB1, CALCA
6osteoporosis29.9TGFB1, MMP3, BMP7, VDR, CALCA
7diabetes mellitus29.8MMP3, TGFB1, CALCA, INS, VDR, BMP7
8cervicitis10.6
9back pain10.6
10blindness10.4
11cauda equina syndrome10.4
12radiculopathy10.4
13achondroplasia10.4
14intermittent claudication10.4
15lumbar disc herniation10.3
16quadriplegia10.3
17hyperostosis10.3
18pseudogout10.2
19spondylitis10.1ACAN
20syringomyelia10.1
21diffuse idiopathic skeletal hyperostosis10.1
22peripheral artery disease10.1
23cerebritis10.1
24artery disease10.1
25lipomatosis10.1
26paraplegia10.1
27central cord syndrome10.1
28foot drop10.1
29ureteral obstruction10.1TGFB1, BMP7
30ureteral disease10.1BMP7, TGFB1
31fibrochondrogenesis10.1COL11A1
32degenerative disc disease10.1COL9A3, COL9A2
33osteochondrodysplasia10.1COL11A2, ACAN
34pulpitis10.1TIMP1
35thyroid cancer, anaplastic10.1CALCA, BMP7, TGFB1
36diastrophic dysplasia10.1COL9A3, COL9A2
37lung giant cell carcinoma10.1TIMP1, TGFB1
38proteinuria10.1BMP7, INS, TGFB1
39multiple epiphyseal dysplasia, dominant10.1COL9A1, COL9A2, COL9A3
40pseudoachondroplasia10.1COL9A1, COL9A2, COL9A3
41pulmonary disease, chronic obstructive10.1TGFB1, TIMP1
42biliary atresia10.1TGFB1, TIMP1
43renal fibrosis10.1TIMP1, TGFB1, BMP7
44multiple epiphyseal dysplasia10.0COL9A1, ACAN, COL9A2, COL9A3
45osteochondritis dissecans10.0ACAN, COL9A2, COL9A3, COL9A1
46galactosemia10.0TGFB1, INS, TIMP1
47hypertrophic scars10.0TGFB1, TIMP1
48proliferative vitreoretinopathy10.0TGFB1, TIMP1, TIMP2
49myelofibrosis10.0TIMP1, TGFB1, TIMP2
50secondary hyperparathyroidism of renal origin10.0VDR, BMP7, CALCA

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to spinal stenosis

Symptoms for Spinal Stenosis

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Drugs & Therapeutics for Spinal Stenosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Spinal Stenosis

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spinal Stenosis

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Anatomical Context for Spinal Stenosis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Spinal Stenosis:

33
Spinal cord, Bone, Testes, Skin, Brain, Lung, Pituitary

FMA organs/tissues related to Spinal Stenosis:

14
Spinal cord

Animal Models for Spinal Stenosis or affiliated genes

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37MGI
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Publications for Spinal Stenosis

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Sources:
52PubMed
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Articles related to Spinal Stenosis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Spinal stenosis. (24365318)
2014
2
Predictors of objectively measured walking capacity in people with degenerative lumbar spinal stenosis. (23948821)
2013
3
Clinical features and surgical outcomes of lumbar spinal stenosis in patients aged 80A years or older: a multi-center retrospective study. (23852590)
2013
4
Obesity is associated with inferior results after surgery for lumbar spinal stenosis: a study of 2633 patients from the Swedish spine register. (22941097)
2013
5
Symptomatic progression of degenerative scoliosis after decompression and limited fusion surgery for lumbar spinal stenosis. (23274034)
2013
6
Lumbar spinal stenosis. (23395043)
2013
7
Re: Macedo LG, Wang Y, BattiAc MC. The sedimentation sign for differential diagnosis of lumbar spinal stenosis. [published online ahead of print November 28, 2012.] Spine. doi:10.1097/BRS.0b013e31827e8ecd. (23660806)
2013
8
Lumbar spinal stenosis impairs function following total knee arthroplasty. (23288774)
2013
9
Spinal Stenosis: Factors That Influence Patients' Decision to Undergo Surgery. (23839025)
2013
10
A comparison of the clinical outcomes of decompression alone and fusion in elderly patients with two-level or more lumbar spinal stenosis. (23440621)
2013
11
Disparities in the outcomes of lumbar spinal stenosis surgery based on insurance status. (23354106)
2013
12
Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. (23473979)
2013
13
Zoster-associated segmental paresis in a patient with cervical spinal stenosis. (23628922)
2013
14
Unilateral approach for bilateral decompression of lumbar spinal stenosis: a minimal invasive surgery. (24304987)
2013
15
Modified Unilateral Laminotomy for Bilateral Decompression for Lumbar Spinal Stenosis-Technical Note. (23466507)
2013
16
Lumbar spinal stenosis: treatment options for an aging population. (23362650)
2012
17
Commentary: Validity and responsiveness of measures of walking in lumbar spinal stenosis--what are we measuring? (22405613)
2012
18
Accuracy and reproducibility of a retrospective outcome assessment for lumbar spinal stenosis surgery. (22642923)
2012
19
Complications in patients undergoing combined transforaminal lumbar interbody fusion and posterior instrumentation with deformity correction for degenerative scoliosis and spinal stenosis. (22439116)
2012
20
Large C4/5 spondylotic disc bulge resulting in spinal stenosis and myelomalacia in a Klippel-Feil patient. (22268974)
2012
21
Commentary: Predictors of outcome from operative management of lumbar spinal stenosis: a plea for better design and reporting practices. (21821199)
2011
22
Lumbar spinal stenosis-diagnosis and management of the aging spine. (21367646)
2011
23
Life dissatisfaction in the pre-operative and early recovery phase predicts low functional ability and coping among post-operative patients with lumbar spinal stenosis: a 2-year prospective study. (20874450)
2011
24
MRI criteria of developmental lumbar spinal stenosis revisited. (22196386)
2011
25
Depression is associated with a poorer outcome of lumbar spinal stenosis surgery: a two-year prospective follow-up study. (21037530)
2011
26
Correlation between disability and MRI findings in lumbar spinal stenosis: a prospective study of 109 patients operated on by decompression. (21434811)
2011
27
Prospective analysis of surgical outcomes in patients undergoing decompressive laminectomy and posterior instrumentation for degenerative lumbar spinal stenosis. (21088465)
2010
28
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications. (20861423)
2010
29
Contemporary management of symptomatic lumbar spinal stenosis. (20399357)
2010
30
Spinal cord injury in cervical spinal stenosis by minor trauma. (20452868)
2010
31
Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia. (21206180)
2010
32
Spinal subarachnoid space pressure measurements in an in vitro spinal stenosis model: implications on syringomyelia theories. (21034148)
2010
33
Technical advances in minimally invasive surgery: direct decompression for lumbar spinal stenosis. (21160392)
2010
34
Diagnosing lumbar spinal stenosis. (20407053)
2010
35
ACP Journal Club. Review: Evidence for the effectiveness of surgery for low back pain, radiculopathy, and spinal stenosis is limited. (19841448)
2009
36
Assessment and management of neurogenic claudication associated with lumbar spinal stenosis in a UK primary care musculoskeletal service: a survey of current practice among physiotherapists. (19796387)
2009
37
Chiropractic treatment of lumbar spinal stenosis: a review of the literature. (19646390)
2009
38
Health-related quality of life (EQ-5D) before and one year after surgery for lumbar spinal stenosis. (19190056)
2009
39
Efficacy of surgery and type of fusion in patients with degenerative lumbar spinal stenosis. (19577930)
2009
40
The clinical effect of gait load test in two level lumbar spinal stenosis. (20404954)
2009
41
Clinical practice. Lumbar spinal stenosis. (18287604)
2008
42
Endoscopic decompression combined with interspinous process implant fusion for lumbar spinal stenosis. (19032852)
2008
43
Surgery may be best way to relieve symptoms of spinal stenosis. (18667961)
2008
44
Clinical outcome of microendoscopic posterior decompression for spinal stenosis associated with degenerative spondylolisthesis--minimum 2-year outcome of 37 patients. (18855290)
2008
45
Degenerative cervical spinal stenosis: current strategies in diagnosis and treatment. (19626174)
2008
46
Treating lumbar spinal stenosis. Medications and physical therapy can help--and so can surgery. (18700289)
2008
47
Spinal stenosis in grade I degenerative lumbar spondylolisthesis: a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion. (15928889)
2005
48
Outcomes of decompression surgery for lumbar spinal stenosis in elderly diabetic patients. (14614597)
2004
49
Quantitative analysis of transforming growth factor-beta 1 in ligamentum flavum of lumbar spinal stenosis and disc herniation. (11679833)
2001
50
Lumbar spinal stenosis secondary to calcium pyrophosphate crystal deposition (pseudogout). (8472402)
1993

Variations for Spinal Stenosis

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Expression for genes affiliated with Spinal Stenosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for genes affiliated with Spinal Stenosis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 5Cell Signaling Technology, 60Thomson Reuters, 53QIAGEN, 12EMD Millipore
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Pathways related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TGFB1, ACAN, BMP7
29.7TGFB1, VDR
39.7COL9A2, COL9A3, COL9A1
49.6TGFB1, COL11A2, COL11A1
59.5TGFB1, TIMP1, TIMP2
69.5ACAN, MMP3, TIMP2
7
Show member pathways
9.3COL9A1, COL9A3, COL9A2, COL6A1
8
Show member pathways
9.3COL6A1, COL9A2, COL9A3, COL9A1
9
Show member pathways
9.3TIMP2, TIMP1, TGFB1, BMP7
10
Show member pathways
9.3TIMP1, TGFB1, BMP7, TIMP2
11
Show member pathways
9.3BMP7, TGFB1, TIMP1, TIMP2
129.3COL11A1, COL6A1, COL11A2, INS
13
Show member pathways
9.3TIMP2, TIMP1, MMP3
149.2TGFB1, ACAN, COL9A2, COL9A3, COL9A1
15
Show member pathways
9.1INS, TIMP2, TIMP1, TGFB1, BMP7
16
Show member pathways
9.1BMP7, TGFB1, TIMP1, TIMP2, INS
17
Show member pathways
9.1INS, TIMP2, TIMP1, TGFB1, BMP7
18
Show member pathways
9.1TIMP2, TIMP1, MMP3, ACAN
19
Show member pathways
8.9INS, TGFB1, COL6A1, COL9A2, COL9A3, COL9A1
20
Show member pathways
8.8TIMP2, TIMP1, TGFB1, MMP3, BMP7
218.7COL11A2, COL6A1, COL9A2, COL11A1, COL9A3, COL9A1
22
Show member pathways
8.2MMP3, COL11A2, COL6A1, COL9A2, COL11A1, COL9A3
23
Show member pathways
8.2INS, TGFB1, MMP3, COL6A1, COL9A2, COL9A3
24
Show member pathways
8.0TGFB1, MMP3, COL11A2, COL6A1, COL9A2, COL11A1
25
Show member pathways
7.5TIMP2, TIMP1, TGFB1, BMP7, COL11A2, COL6A1
26
Show member pathways
7.5BMP7, TGFB1, TIMP1, TIMP2, COL11A2, COL6A1
27
Show member pathways
6.8COL9A1, TIMP2, TIMP1, TGFB1, MMP3, ACAN

Compounds for genes affiliated with Spinal Stenosis

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 3BitterDB, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR
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Compounds related to Spinal Stenosis according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1calcium gluconate4510.2INS, CALCA
2safranin o4510.0MMP3, BMP7, ACAN
3methyl selenol459.9TIMP1, TIMP2
4sorbinil45 1110.9TIMP2, TIMP1
5thiazide459.9CALCA, INS, VDR
6rhein459.8TIMP1, TGFB1
7agarose459.8BMP7, TIMP2, ACAN, TGFB1
8pyridinoline459.8MMP3, CALCA, TIMP1
9hydroxyproline45 24 1111.7TGFB1, TIMP2, TIMP1, CALCA
10streptozotocin459.7TIMP1, INS, TGFB1
11latanoprost45 1110.7TIMP2, MMP3, TIMP1
12(4-aminophenyl)mercuric acetate459.7MMP3, TIMP2, TIMP1
13deoxypyridinoline459.6VDR, MMP3, CALCA
14beta-ionone459.6TIMP2, TIMP1
15hydroxamate459.6TIMP1, MMP3, TIMP2
16thyroxine45 2410.6INS, VDR, CALCA, TGFB1
17propionate459.6TIMP1, TIMP2, MMP3
18procollagen459.6ACAN, TGFB1, MMP3, TIMP1
191,10-phenanthroline45 310.5TIMP2, MMP3, TIMP1
20batimastat45 61 1111.5MMP3, TIMP1, TIMP2
21etidronic acid45 51 1111.5CALCA, VDR
22alginate459.4ACAN, MMP3, TGFB1, BMP7, TIMP1
23tgf beta1459.4BMP7, TGFB1, ACAN, TIMP1, MMP3
24troglitazone45 29 61 1112.4VDR, INS, MMP3, TGFB1
25cytochalasin d45 6110.4TIMP2, MMP3, TIMP1, TGFB1
26calcitriol45 61 24 1112.3VDR, CALCA, BMP7, TGFB1, TIMP1
27glycosaminoglycan459.3TIMP2, ACAN, MMP3, TGFB1, TIMP1
28hyaluronic acid45 2410.3ACAN, TIMP2, MMP3, TGFB1, TIMP1
29ribonucleic acid459.2TIMP2, BMP7, MMP3, TIMP1, TGFB1
30pd 98,059459.2MMP3, ACAN, TGFB1, TIMP1, TIMP2
31glyceraldehyde 3-phosphate459.2ACAN, TIMP2, TIMP1, MMP3
32tacrolimus45 51 1111.2INS, TIMP2, TIMP1, VDR, TGFB1
33ascorbic acid45 2410.1ACAN, BMP7, MMP3, TIMP2, VDR
34methotrexate51 45 1111.0MMP3, TIMP2, TGFB1, TIMP1
35lactate459.0CALCA, MMP3, TIMP1, TIMP2, TGFB1, INS
36alendronate45 51 1111.0TIMP2, TIMP1, MMP3, CALCA, VDR
37vegf458.9CALCA, MMP3, TGFB1, TIMP1, TIMP2, BMP7
38glutamine458.9VDR, COL9A2, MMP3, TGFB1, TIMP1
39butyrate458.9TGFB1, TIMP1, TIMP2, VDR, MMP3
40sb 20358045 619.8VDR, ACAN, TIMP2, TIMP1, TGFB1, MMP3
41creatinine458.7INS, TGFB1, MMP3, BMP7, CALCA, VDR
42cyclosporin a45 29 6110.7VDR, TIMP2, TIMP1, TGFB1, MMP3, CALCA
43glutamate458.7INS, VDR, TIMP1, MMP3, ACAN, CALCA
44cycloheximide458.7BMP7, TIMP1, VDR, MMP3, TGFB1, TIMP2
45vitamin d458.7TGFB1, MMP3, CALCA, VDR, ACAN, BMP7
46dexamethasone45 51 29 1111.6VDR, TIMP1, BMP7, TGFB1, ACAN, MMP3
47alanine458.5INS, TGFB1, VDR, TIMP2, TIMP1, MMP3
48retinoic acid45 249.5BMP7, ACAN, TGFB1, TIMP1, VDR, TIMP2
49pge2458.4CALCA, BMP7, MMP3, ACAN, TIMP2, TIMP1
50estrogen458.3TIMP1, MMP3, INS, VDR, TIMP2, BMP7

GO Terms for genes affiliated with Spinal Stenosis

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Sources:
16Gene Ontology
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Cellular components related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type XIGO:0055929.8COL11A1, COL11A2
2extracellular matrixGO:0310129.7COL6A1, BMP7, ACAN
3collagen type IXGO:0055949.7COL9A2, COL9A3, COL9A1
4Golgi lumenGO:0057969.5ACAN, TGFB1, INS
5extracellular spaceGO:0056158.7INS, TIMP2, TGFB1, MMP3, BMP7, CALCA
6endoplasmic reticulum lumenGO:0057888.6INS, COL11A2, COL6A1, COL9A2, COL11A1, COL9A3
7extracellular regionGO:0055765.7CALCA, INS, TIMP2, TIMP1, DCD, TGFB1

Biological processes related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:03328010.2BMP7, TGFB1
2positive regulation of cellular protein metabolic processGO:03227010.2TGFB1, INS
3positive regulation of peptidyl-threonine phosphorylationGO:01080010.2BMP7, TGFB1
4negative regulation of ossificationGO:03027910.2TGFB1, CALCA
5positive regulation of adenylate cyclase activityGO:04576210.2CALCA, TIMP2
6positive regulation of vasodilationGO:04590910.1CALCA, INS
7negative regulation of mitotic cell cycleGO:04593010.0TGFB1, TIMP2
8negative regulation of proteolysisGO:0458619.9INS, TIMP2
9positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.8TGFB1, BMP7
10agingGO:0075689.6TIMP2, TIMP1, CALCA, TGFB1
11axon guidanceGO:0074119.4COL6A1, COL9A3, COL9A2, BMP7, COL9A1
12skeletal system developmentGO:0015019.3COL11A2, BMP7, ACAN, VDR, COL9A2
13negative regulation of transcription, DNA-templatedGO:0458929.2BMP7, TGFB1, VDR, CALCA
14collagen catabolic processGO:0305748.5MMP3, COL11A2, COL6A1, COL9A2, COL9A1, COL11A1
15extracellular matrix disassemblyGO:0226177.6COL11A1, COL9A2, COL6A1, COL11A2, ACAN, MMP3
16extracellular matrix organizationGO:0301987.1TGFB1, COL9A1, COL9A3, COL11A1, COL9A2, TIMP1

Molecular functions related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:0081919.4TIMP2, TIMP1
2extracellular matrix structural constituent conferring tensile strengthGO:0300209.3COL11A2, COL9A2, COL9A3, COL9A1
3protein bindingGO:0055157.6VDR, INS, TIMP2, TIMP1, TGFB1, TSSK4

Products for genes affiliated with Spinal Stenosis

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  • Antibodies
  • Proteins
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Sources for Spinal Stenosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet