MCID: SPN027
MIFTS: 54

Spinal Stenosis malady

Summaries for Spinal Stenosis

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. spinal stenosis causes narrowing in your spine. the narrowing puts pressure on your nerves and spinal cord and can cause pain. spinal stenosis occurs mostly in people older than 50. younger people with a spine injury or a narrow spinal canal are also at risk. diseases such as arthritis and scoliosis can cause spinal stenosis, too. symptoms might appear gradually or not at all. they include pain in your neck or back numbness, weakness, cramping, or pain in your arms or legs pain going down the leg foot problems doctors diagnose spinal stenosis with a physical exam and imaging tests. treatments include medications, physical therapy, braces, and surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and radiculopathy. An important gene associated with Spinal Stenosis is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are RXR and RAR heterodimerization with other nuclear receptor and Endochondral Ossification. The compounds calcium gluconate and etidronic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, spinal cord and bone, and related mouse phenotypes are hearing/vestibular/ear and skeleton.

Disease Ontology:8 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia:63 Spinal stenosis is an abnormal narrowing (stenosis) of the spinal canal that may occur in any of the... more...

Aliases & Classifications for Spinal Stenosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

spinal stenosis 8 10 44 33 30 60
spinal stenosis of lumbar region 8 60
spinal stenosis in cervical region 60
cervical spinal stenosis 8
lumbar spinal stenosis 8


Related Diseases for Spinal Stenosis

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17GeneCards, 18GeneDecks
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Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1spondylolisthesis30.9BMP7, TSSK4, FTH1
2radiculopathy30.5COL6A1, KLK8, HSF4
3osteoarthritis30.5COL11A2, COL9A1, TGFB1, ACAN, VDR, BMP7
4renal osteodystrophy30.2BMP7, VDR, CALCA
5spondylosis30.1COL6A1, TSSK4
6osteoporosis29.9CALCA, TGFB1, VDR, BMP7
7diabetes mellitus29.8CALCA, TGFB1, INS, FTH1, VDR, BMP7
8cervicitis10.6
9intermittent claudication10.4
10achondroplasia10.4
11cauda equina syndrome10.4
12quadriplegia10.3
13hyperostosis10.3
14pseudogout10.2
15osteoporotic fracture10.1
16diffuse idiopathic skeletal hyperostosis10.1
17syringomyelia10.1
18cerebritis10.1
19lipomatosis10.1
20paraplegia10.1
21short stature10.0INS
22myopia 610.0COL11A2
23nephrosclerosis10.0TGFB1
24spondylitis10.0ACAN
25hypothyroidism10.0INS
26hypoparathyroidism10.0CALCA
27hemochromatosis10.0FTH1
28myelodysplastic syndromes10.0VDR
29cataract10.0HSF4
30cleft palate10.0COL11A2
31alpha thalassemia10.0FTH1
32intracranial hypotension10.0HSF4
33hyperparathyroidism10.0VDR, CALCA
34scheuermann's disease10.0COL9A3
35diabetic retinopathy10.0INS
36duodenal ulcer10.0INS
37myopathy10.0INS, COL6A1
38spinal cord disease10.0COL6A1, HSF4
39diastrophic dysplasia10.0COL9A3, COL9A2
40hypogonadism10.0CALCA, INS
41parathyroid adenoma10.0VDR, CALCA
42migraine10.0CALCA
43degenerative disc disease10.0COL9A3, COL9A2
44nephrolithiasis10.0VDR
45graves' disease10.0VDR
46secondary hyperparathyroidism of renal origin10.0CALCA, VDR, BMP7
47thyroid cancer, anaplastic10.0TGFB1, CALCA, BMP7
48proteinuria10.0BMP7, INS, TGFB1
49ureteral disease10.0BMP7, TGFB1
50lumbar disc disease10.0VDR, COL9A3, COL9A2

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to spinal stenosis

Clinical Features for Spinal Stenosis

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Drugs & Therapeutics for Spinal Stenosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Spinal Stenosis

Drug clinical trials:

Search ClinicalTrials for Spinal Stenosis

Search NIH Clinical Center for Spinal Stenosis

Search CenterWatch for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 20528753

Genetic Tests for Spinal Stenosis

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Anatomical Context for Spinal Stenosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Spinal Stenosis:

32
Spinal cord, Bone, Testes, Skin, Brain, Lung, Cortex, Pituitary

FMA organs/tissues related to Spinal Stenosis:

14
Spinal cord

Animal Models for Spinal Stenosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spinal Stenosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6ACAN, BMP7, COL9A1
2MP:00053909.4COL9A1, CALCA, BMP7, VDR, INS, ACAN

Publications for Spinal Stenosis

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Sources:
50PubMed
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Articles related to Spinal Stenosis:

(show top 50)    (show all 600)
idTitleAuthorsYear
1
Life dissatisfaction burden is associated with a poor surgical outcome among lumbar spinal stenosis patients: a 5-year follow-up study. (24135635)
2014
2
Predictors of objectively measured walking capacity in people with degenerative lumbar spinal stenosis. (23948821)
2013
3
Re: Macedo LG, Wang Y, BattiAc MC. The sedimentation sign for differential diagnosis of lumbar spinal stenosis. [published online ahead of print November 28, 2012.] Spine. doi:10.1097/BRS.0b013e31827e8ecd. (23660806)
2013
4
Nationwide trends in the surgical management of lumbar spinal stenosis. (23324922)
2013
5
Hypertrophy and Fibrosis of the Ligamentum Flavum in Lumbar Spinal Stenosis is Associated with Increased Expression of LPA and LPAR1. (24247031)
2013
6
X-STOP surgical implant for the treatment of lumbar spinal stenosis: clinical practice recommendations for neurosurgical nurse practitioners. (23291871)
2013
7
Increased intraoperative epidural pressure in lumbar spinal stenosis patients with a positive nerve root sedimentation sign. (24166020)
2013
8
Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery. (23924165)
2013
9
Associations of self-report measures with gait, range of motion and proprioception in patients with lumbar spinal stenosis. (23810090)
2013
10
Re: Radcliff K, Kepler C, Hilibrand A, et al. Epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis: a subgroup analysis of the spine patient outcomes research trial. Spine (Phila Pa 1976). 2013;38:279a8991. (23900112)
2013
11
Complications in patients undergoing combined transforaminal lumbar interbody fusion and posterior instrumentation with deformity correction for degenerative scoliosis and spinal stenosis. (22439116)
2012
12
Clinical characteristics and surgical outcome of the symptomatic ossification of ligamentum flavum at the thoracic level with combined lumbar spinal stenosis. (22139388)
2012
13
Changes in vitamin D status after surgery in female patients with lumbar spinal stenosis and its clinical significance. (22805343)
2012
14
Minimally invasive surgical treatment of lumbar spinal stenosis: Two-year follow-up in 54 patients. (22530175)
2012
15
Unilateral laminotomy with bilateral decompression for lumbar spinal stenosis: short-term risks in elderly individuals. (23162966)
2012
16
Clinical experiences of transforaminal balloon decompression for patients with spinal stenosis. (22259719)
2012
17
Walking assessment in people with lumbar spinal stenosis: capacity, performance, and self-report measures. (21145292)
2011
18
Dural sac cross-sectional area does not correlate with efficacy of percutaneous adhesiolysis in single level lumbar spinal stenosis. (21785481)
2011
19
Spinaplasty following lumbar laminectomy for multilevel lumbar spinal stenosis to prevent iatrogenic instability. (21886919)
2011
20
Minimally invasive treatment of moderate lumbar spinal stenosis with the superion interspinous spacer. (22043255)
2011
21
Bilateral operation of lumbar degenerative central spinal stenosis in full-endoscopic interlaminar technique with unilateral approach: prospective 2-year results of 74 patients. (20975592)
2011
22
Efficacy of interspinous device versus surgical decompression in the treatment of lumbar spinal stenosis: a modified network analysis. (22956936)
2011
23
Spinal cord injury in cervical spinal stenosis by minor trauma. (20452868)
2010
24
Lumbar spinal stenosis: a brief review of the nonsurgical management. (20428988)
2010
25
Degenerative spondylolisthesis versus spinal stenosis: does a slip matter? Comparison of baseline characteristics and outcomes (SPORT). (20075768)
2010
26
Degenerative lumbar spinal stenosis and lumbar spine configuration. (20652366)
2010
27
Qualitative grading of severity of lumbar spinal stenosis based on the morphology of the dural sac on magnetic resonance images. (20671589)
2010
28
Rare ligamentum flavum cyst causing incapacitating lumbar spinal stenosis: Experience with 3 Chinese patients. (21047439)
2010
29
Protocol for evaluation of the comparative effectiveness of percutaneous adhesiolysis and caudal epidural steroid injections in low back and/or lower extremity pain without post surgery syndrome or spinal stenosis. (20309389)
2010
30
Effectiveness of exercise in the treatment of lumbar spinal stenosis, knee osteoarthritis, and osteoporosis. (19920410)
2010
31
The analysis of the factors affecting lumbar spinal stenosis in adult patients. (20162467)
2010
32
Algorithmic approach to the management of the patient with lumbar spinal stenosis. (20733968)
2010
33
Efficacy of surgery and type of fusion in patients with degenerative lumbar spinal stenosis. (19577930)
2009
34
The efficacy of physical therapy and physical therapy plus calcitonin in the treatment of lumbar spinal stenosis. (19881973)
2009
35
Concomitant noncontiguous level (thoracic & lumbar) spinal stenosis. (18414858)
2009
36
Clinical outcomes of microendoscopic decompressive laminotomy for degenerative lumbar spinal stenosis. (19238459)
2009
37
Surgical treatment of lumbar spinal stenosis associated with adult scoliosis. (19385576)
2009
38
One-staged combined cervical and lumbar decompression for patients with tandem spinal stenosis on cervical and lumbar spine: analyses of clinical outcomes with minimum 3 years follow-up. (19956034)
2009
39
Lumbar spinal stenosis. (18557179)
2008
40
Dynamic neutralization of the lumbar spine after microsurgical decompression in acquired lumbar spinal stenosis and segmental instability. (18303447)
2008
41
JAMA patient page. Spinal stenosis. (18314441)
2008
42
Spinal stenosis. (18764759)
2008
43
Clinical outcome of nonoperative treatment for lumbar spinal stenosis, and predictive factors relating to prognosis, in a 5-year minimum follow-up. (19057249)
2008
44
Spinal stenosis: assessment of motor function, VEGF expression and angiogenesis in an experimental model in the rat. (17992557)
2007
45
The distended facet sign: an indicator of position-dependent spinal stenosis and degenerative spondylolisthesis. (17321977)
2007
46
Dynamic stabilization in addition to decompression for lumbar spinal stenosis with degenerative spondylolisthesis. (16481955)
2006
47
Spinal stenosis in grade I degenerative lumbar spondylolisthesis: a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion. (15928889)
2005
48
Buschke-Ollendorff syndrome, otosclerosis, and congenital spinal stenosis. (8170846)
1994
49
Achondroplasia and lumbar spinal stenosis. (1797731)
1991
50
Autosomal dominant osteosclerosis associated with familial spinal canal stenosis. (3703268)
1986

Genetic Variations for Spinal Stenosis

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Expression for genes affiliated with Spinal Stenosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for genes affiliated with Spinal Stenosis

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
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Pathways related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2TGFB1, VDR
210.0BMP7, ACAN, TGFB1
3
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10.0COL9A1, COL6A1, COL11A2
49.9TGFB1, ACAN, KLK8
5
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9.8COL6A1, COL9A1, COL9A2, COL9A3
6
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9.8COL6A1, COL9A1, COL9A2, COL9A3
7
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9.7COL9A3, COL9A2, COL9A1, COL6A1, COL11A2
8
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9.7COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
99.7COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
10
Hide members
9.4COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, BMP7
11
Hide members
9.4COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, BMP7
12
Hide members
9.1ACAN, KLK8, COL11A2, COL6A1, COL9A1, COL9A2

Compounds for genes affiliated with Spinal Stenosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1calcium gluconate4410.5INS, CALCA
2etidronic acid44 49 1112.4CALCA, VDR
3safranin o4410.4BMP7, ACAN
4thiazide4410.4INS, VDR, CALCA
5dmsa4410.4VDR, CALCA
6alfacalcidol44 59 1112.3CALCA, VDR
7alginate4410.3BMP7, ACAN, TGFB1
824,25-dihydroxyvitamin d34410.3CALCA, VDR
9thyroxine44 2411.2TGFB1, INS, VDR, CALCA
10calcitriol44 59 11 2413.2TGFB1, VDR, BMP7, CALCA
11i-app4410.1CALCA, INS
121,25 dihydroxy vitamin d34410.1TGFB1, VDR, CALCA
13vitamin d4410.0CALCA, BMP7, VDR, ACAN, TGFB1
14pge24410.0CALCA, BMP7, VDR, ACAN, TGFB1
15creatinine449.9CALCA, BMP7, VDR, INS, TGFB1
16pramlintide44 1110.9INS, CALCA
17ascorbic acid44 2410.8ACAN, FTH1, VDR, BMP7

GO Terms for genes affiliated with Spinal Stenosis

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16Gene Ontology
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Cellular components related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0TGFB1, ACAN, INS
2collagen type IXGO:0055949.6COL9A1, COL9A2, COL9A3
3endoplasmic reticulum lumenGO:0057889.2INS, COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
4extracellular regionGO:0055768.6COL11A2, COL6A1, COL9A1, COL9A2, COL9A3, CALCA

Biological processes related to Spinal Stenosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ossificationGO:03027910.2TGFB1, CALCA
2positive regulation of cellular protein metabolic processGO:03227010.1TGFB1, INS
3positive regulation of peptidyl-threonine phosphorylationGO:0108009.9TGFB1, BMP7
4collagen catabolic processGO:0305749.8COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
5extracellular matrix disassemblyGO:0226179.8COL11A2, COL6A1, COL9A1, COL9A2, COL9A3
6skeletal system developmentGO:0015019.8ACAN, VDR, BMP7, COL9A2, COL11A2
7axon guidanceGO:0074119.7COL6A1, COL9A1, COL9A2, COL9A3, BMP7
8extracellular matrix organizationGO:0301989.4TGFB1, COL11A2, COL6A1, COL9A1, COL9A2, COL9A3

Molecular functions related to Spinal Stenosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:0300209.8COL9A3, COL9A2, COL9A1, COL11A2

Products for genes affiliated with Spinal Stenosis

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  • Antibodies
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Sources for Spinal Stenosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet