MCID: SPN032
MIFTS: 42

Spindle Cell Carcinoma malady

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

Aliases & Descriptions for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 14
Carcinoma, Spindle-Cell 69
Carcinoma Spindle Cell 52
Sarcomatoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 42 D002277
NCIt 47 C27004
SNOMED-CT 64 23109009 65692009
UMLS 69 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to osteomyelitis and rectum sarcomatoid carcinoma. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Sunitinib and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and skin, and related phenotype is mortality/aging.

Wikipedia : 71 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
id Related Disease Score Top Affiliating Genes
1 osteomyelitis 29.7 ACTC1 DES VIM
2 rectum sarcomatoid carcinoma 11.9
3 thymus sarcomatoid carcinoma 11.9
4 sarcomatoid squamous cell skin carcinoma 11.2
5 sarcomatoid transitional cell carcinoma 10.9
6 sarcomatoid penile squamous cell carcinoma 10.8
7 lymphomatoid papulosis 10.3 ACTC1 VIM
8 chest wall parachordoma 10.3 ACTC1 VIM
9 immunodeficiency due to a classical component pathway complement deficiency 10.3 MUC1 VIM
10 isolated anterior cervical hypertrichosis 10.3 ACTC1 VIM
11 lacrimal gland mucoepidermoid carcinoma 10.3 MUC1 PGR
12 inflammatory linear verrucous epidermal nevus 10.3 DES VIM
13 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.3 MUC1 VIM
14 mucinous cystadenocarcinoma 10.3 ACTC1 MUC1
15 cervical lymphoepithelioma-like carcinoma 10.3 MUC1 PGR
16 pericardium leiomyoma 10.3 ACTC1 PGR
17 ovarian squamous cell carcinoma 10.3 CDH1 VIM
18 oral erosive lichen 10.3 ACTC1 DES
19 hydrarthrosis 10.3 ACTC1 PGR
20 exotropia 10.3 MUC1 PGR
21 carbon monoxide-induced parkinsonism 10.3 ACTC1 DES
22 invasive malignant thymoma 10.3 DES MUC1
23 subglottis verrucous carcinoma 10.3 MUC1 VIM
24 ovarian cystadenoma 10.3 DES MUC1
25 skeletal-extraskeletal angiomatosis 10.3 MUC1 SYP
26 lymphangiosarcoma 10.3 ACTC1 MUC1 VIM
27 clear cell ependymoma 10.3 MUC1 VIM
28 larynx verrucous carcinoma 10.2 CDH1 VIM
29 jejunal neuroendocrine tumor 10.2 SYP VIM
30 desmoid tumor 10.2 ACTC1 MUC1 VIM
31 differentiating neuroblastoma 10.2 CDH1 MUC1 VIM
32 endometrial stromal sarcoma 10.2 MUC1 PGR VIM
33 progressive multifocal leukoencephalopathy 10.2 AMACR VIM
34 bladder adenocarcinoma 10.2 MUC1 PGR VIM
35 myxopapillary ependymoma 10.2 SYP VIM
36 atypical lipomatous tumor 10.2 PGR TP63
37 biliary papillomatosis 10.2 DES MUC1 VIM
38 porokeratosis 10.2 MUC1 PGR
39 13q12.3 microdeletion syndrome 10.2 ACTC1 DES VIM
40 petrous apex meningioma 10.2 DES MUC1 VIM
41 anal gland neoplasm 10.2 DES MUC1 VIM
42 occlusion precerebral artery 10.2 ACTC1 MUC1 VIM
43 congenital myasthenic syndrome 10.2 ACTC1 DES VIM
44 malignant dermis tumor 10.2 ACTC1 DES VIM
45 sternum cancer 10.2 MUC1 VIM
46 urethral cancer 10.2 ACTC1 DES VIM
47 kidney benign neoplasm 10.2 MUC1 PGR VIM
48 adult central nervous system primitive neuroectodermal neoplasm 10.2 SYP VIM
49 intestinal obstruction 10.2 ACTC1 DES VIM
50 vagina leiomyosarcoma 10.2 ACTC1 DES MUC1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.32 ACTC1 AMACR CDH1 DES KRT14 KRT5

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
2
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6
Succinylcholine Approved Phase 2 306-40-1 5314
7
nivolumab Approved Phase 2 946414-94-4
8
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Mitogens Phase 2
12 Endothelial Growth Factors Phase 2
13 Immunoglobulins Phase 2
14 Anti-Infective Agents Phase 2
15 Antibodies, Monoclonal Phase 2
16 Immunosuppressive Agents Phase 2
17 Antimetabolites Phase 2
18 Antimetabolites, Antineoplastic Phase 2
19 Antibodies Phase 2
20 Antiviral Agents Phase 2
21
tremelimumab Phase 2
22 Neuromuscular Agents Phase 2
23 Neuromuscular Blocking Agents Phase 2
24 Neuromuscular Depolarizing Agents Phase 2
25 Peripheral Nervous System Agents Phase 2
26 Albumin-Bound Paclitaxel Phase 2
27 Antimitotic Agents Phase 2
28 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2
2 Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2
3 A Phase I/II Trial of Crolibulin (EPC2407) Plus Cisplatin in Adults With Solid Tumors With a Focus on Anaplastic Thyroid Cancer (ATC) Completed NCT01240590 Phase 1, Phase 2
4 Pulmonary sarcomatoid_MEDI4736+Treme Recruiting NCT03022500 Phase 2
5 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
6 Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery Recruiting NCT02734537 Phase 2
7 A Phase II Study of HMPL-504 in Lung Sarcomatoid Carcinoma Not yet recruiting NCT02897479 Phase 2
8 Alisertib in Chemotherapy-pretreated Urothelial Cancer Not yet recruiting NCT02109328 Phase 2

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

39
Kidney, Breast, Skin, Lung, Tongue, Thyroid, Lymph Node

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 285)
id Title Authors Year
1
CT and MR imaging features of mucinous tubular and spindle cell carcinoma of the kidneys. A multi-institutional review. ( 27334016 )
2016
2
Spindle Cell Carcinoma of the Mandibular Gingiva - A Case Report. ( 27042594 )
2016
3
Spindle cell carcinoma of the esophagus: A multicenter analysis in comparison with typical squamous cell carcinoma. ( 27631227 )
2016
4
Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. ( 27764039 )
2016
5
Spindle cell carcinoma of the conjunctiva: A rare entity. ( 27380985 )
2016
6
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study. ( 27491291 )
2016
7
Spindle cell carcinoma of the tongue combined with double primary cancer of the thyroid gland: a case report. ( 27595090 )
2016
8
Spindle cell carcinoma of the mandible: Clinicopathological and immunohistochemical characteristics. ( 27195215 )
2016
9
Spindle Cell Carcinoma of Nasal Cavity- A Case Report. ( 27190843 )
2016
10
Bi-allelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. ( 27604489 )
2016
11
Sinonasal spindle cell carcinoma presenting with bilateral visual loss: A case report and review of the literature. ( 27347158 )
2016
12
Spindle cell carcinoma of the breast: a comprehensive analysis. ( 26830716 )
2016
13
Expression of p40 and laminin 332 in metaplastic spindle cell carcinoma of the breast compared with other malignant spindle cell tumours. ( 25795733 )
2015
14
Comparative study of CT appearances in mucinous tubular and spindle cell carcinoma and collecting duct carcinoma of the kidney. ( 26435393 )
2015
15
Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients. ( 26635898 )
2015
16
Clinicopathological characteristics of kidney mucinous tubular and spindle cell carcinoma. ( 25755810 )
2015
17
Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms undergoing epithelial-mesenchymal transition. ( 25420898 )
2015
18
Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival. ( 25994520 )
2015
19
Renal mucinous tubular and spindle cell carcinoma: report of four cases and literature review. ( 26045827 )
2015
20
Cutaneous spindle cell carcinoma misdiagnosed as atypical fibroxanthoma based on immunohistochemical stains. ( 27051790 )
2015
21
Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. ( 25699980 )
2015
22
A Case of Granulocyte-Colony Stimulating Factor-Producing Spindle Cell Carcinoma of the Breast. ( 25823685 )
2015
23
An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage. ( 26558362 )
2015
24
Low-Grade Fibromatosis-like Spindle Cell Carcinoma of the Breast. ( 25822766 )
2015
25
Osseous Metaplasia in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Case of Massive, Bilateral Tumors. ( 26347846 )
2015
26
Mucinous tubular and spindle cell carcinoma of kidney: A case report of an unusual tumor. ( 26458668 )
2015
27
Spindle cell carcinoma arising at the buccal mucosa: a case report and review of the literature. ( 25547144 )
2015
28
Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician. ( 26788392 )
2015
29
(18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. ( 25589812 )
2015
30
Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. ( 25713418 )
2015
31
Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck. ( 26203085 )
2015
32
Wide expression of ZEB1 in sarcomatous component of spindle cell carcinoma of the esophagus. ( 26515382 )
2015
33
Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. ( 25785207 )
2015
34
Mucinous tubular and spindle cell carcinoma of the kidney: Diagnosis by fine needle aspiration and review of the literature. ( 26884801 )
2015
35
Spindle cell carcinoma of the breast as complex cystic lesion: a case report. ( 25009755 )
2014
36
Contrast-enhanced ultrasound characterization of renal mucinous tubular and spindle cell carcinoma: Report of two cases. ( 24706525 )
2014
37
Mucinous tubular and spindle cell carcinoma and solid variant papillary renal cell carcinoma: a clinicopathologic comparative analysis of four cases with similar molecular genetics datum. ( 25476569 )
2014
38
Management of spindle cell carcinoma of the maxillary sinus: a case report and literature review. ( 25350698 )
2014
39
Mucinous tubular and spindle cell carcinoma of the kidney: the contrast-enhanced ultrasonography and CT features of six cases and review of the literature. ( 25158894 )
2014
40
Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case. ( 25328308 )
2014
41
Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. ( 24634155 )
2014
42
HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast. ( 25309767 )
2014
43
Renal mucinous tubular and spindle cell carcinoma and 18F-fluorodeoxyglucose-PET/CT findings. ( 24815536 )
2014
44
Mucinous tubular and spindle cell carcinoma of the kidney: a rare case diagnosed in the early postpartum. ( 24619013 )
2014
45
Sarcomatoid variant of urothelial carcinoma (carcinosarcoma, spindle cell carcinoma): a review of the literature. ( 24587922 )
2014
46
Spindle cell carcinoma of the vulva: a series of 4 cases and review of the literature. ( 24487477 )
2014
47
Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney: A Retrospective Detailed Study of Radiologic, Pathologic and Clinical Outcomes. ( 25395040 )
2014
48
Mucinous, tubular and spindle cell carcinoma of kidney: report of two cases with pathological differences. ( 25407154 )
2014
49
Mucinous tubular and spindle cell carcinoma of the kidney: A case report and review of the literature. ( 24520298 )
2014
50
Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma. ( 25114719 )
2014

Variations for Spindle Cell Carcinoma

Cosmic variations for Spindle Cell Carcinoma:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM45765 TP53 skin,leg,carcinoma,squamous cell carcinoma c.987C>A p.T329T 9
2 COSM45114 TP53 skin,leg,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 9
3 COSM10863 TP53 skin,leg,carcinoma,squamous cell carcinoma c.833C>T p.P278L 9
4 COSM498 HRAS skin,leg,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 9

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.65 ACTC1 CDH1 DES KRT5 KRT8 MUC1
2
Show member pathways
11.39 DES KRT14 KRT5 KRT8 VIM
3 11.29 ACTC1 DES VIM
4 10.59 CDH1 CDH16 VIM

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.9 ACTC1 AMACR CDH1 DES KRT14 KRT5
2 extracellular exosome GO:0070062 9.61 ACTC1 CDH1 CDH16 DES KRT14 KRT5
3 keratin filament GO:0045095 9.43 KRT14 KRT5 KRT8
4 intermediate filament GO:0005882 9.02 DES KRT14 KRT5 KRT8 VIM

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT14 KRT5 KRT8
2 epidermis development GO:0008544 9.43 KRT14 KRT5 TP63
3 intermediate filament organization GO:0045109 9.4 DES VIM
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 MUC1 TP63
5 hemidesmosome assembly GO:0031581 9.16 KRT14 KRT5
6 epithelial cell differentiation GO:0030855 9.13 KRT14 MUC1 TP63
7 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratin filament binding GO:1990254 9.16 KRT14 VIM
2 scaffold protein binding GO:0097110 9.13 KRT5 KRT8 VIM
3 structural constituent of cytoskeleton GO:0005200 8.92 DES KRT14 KRT5 VIM

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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