MCID: SPN032
MIFTS: 43

Spindle Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

MalaCards integrated aliases for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 14
Carcinoma, Spindle-Cell 69
Carcinoma Spindle Cell 51
Sarcomatoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 41 D002277
NCIt 46 C27004
SNOMED-CT 64 23109009 65692009
UMLS 69 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to sarcomatoid mesothelioma and fibromatosis. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Sunitinib and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lung.

Wikipedia : 72 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 362)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid mesothelioma 30.7 MUC1 VIM
2 fibromatosis 30.5 ACTC1 DES VIM
3 renal cell carcinoma, papillary, 1 30.3 AMACR CDH16 KRT7
4 squamous cell carcinoma 30.3 CDH1 KRT7 MUC1 TP63
5 collecting duct carcinoma 30.1 AMACR KRT7 VIM
6 inflammatory myofibroblastic tumor 29.9 ACTC1 DES VIM
7 pulmonary blastoma 29.8 DES SYP
8 benign breast phyllodes tumor 29.8 PGR TP63 VIM
9 large cell neuroendocrine carcinoma 29.7 ENO2 KRT7 SYP
10 transitional cell carcinoma 29.6 CDH1 ENO2 KRT7
11 granular cell tumor 29.6 DES ENO2 VIM
12 small cell carcinoma 29.5 ENO2 KRT7 SYP
13 merkel cell carcinoma 29.2 ENO2 KRT7 MUC1 SYP
14 renal cell carcinoma, nonpapillary 28.8 AMACR CDH1 CDH16 ENO2 KRT7 MUC1
15 oncocytoma 28.7 AMACR CDH16 KRT7 MUC1 SYP VIM
16 thymus sarcomatoid carcinoma 12.1
17 rectum sarcomatoid carcinoma 12.0
18 sarcomatoid squamous cell skin carcinoma 11.7
19 sarcomatoid penile squamous cell carcinoma 11.3
20 sarcomatoid transitional cell carcinoma 11.0
21 sarcomatoid renal cell carcinoma 11.0
22 glandular cystitis 10.6 KRT7 MUC1
23 malignant peritoneal mesothelioma 10.6 MUC1 VIM
24 bladder diverticulum 10.6 AMACR KRT7
25 lymphangiectasis 10.6 ACTC1 VIM
26 glomangiomyoma 10.6 ACTC1 VIM
27 renal adenoma 10.6 AMACR KRT7
28 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT7 MUC1
29 fibrous meningioma 10.5 MUC1 VIM
30 intravascular papillary endothelial hyperplasia 10.5 ACTC1 VIM
31 clear cell papillary renal cell carcinoma 10.5 AMACR KRT7
32 bile duct cystadenocarcinoma 10.5 KRT7 MUC1
33 epithelial predominant wilms' tumor 10.5 AMACR KRT7
34 eccrine papillary adenocarcinoma 10.5 KRT7 PGR
35 large intestine adenocarcinoma 10.5 CDH1 KRT7
36 linitis plastica 10.5 CDH1 KRT7
37 ovarian mucinous adenocarcinoma 10.5 AMACR KRT7
38 breast mucoepidermoid carcinoma 10.5 MUC1 PGR
39 myxopapillary ependymoma 10.5 MUC1 VIM
40 adenomyoma 10.5 KRT7 MUC1
41 skin glomus tumor 10.5 DES VIM
42 female reproductive endometrioid cancer 10.5 KRT7 PGR
43 infantile digital fibromatosis 10.5 DES VIM
44 oncocytic breast carcinoma 10.5 KRT7 PGR
45 esophagus squamous cell carcinoma 10.5 CDH1 VIM
46 breast scirrhous carcinoma 10.5 MUC1 PGR
47 adenomatoid tumor 10.5 KRT7 VIM
48 calcifying aponeurotic fibroma 10.5 ACTC1 PGR
49 cystic basal cell carcinoma 10.5 KRT7 TP63
50 gastric diffuse adenocarcinoma 10.5 CDH1 KRT7

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
4
Gemcitabine Approved Phase 2 95058-81-4 60750
5
nivolumab Approved Phase 2 946414-94-4
6
Tremelimumab Investigational Phase 2 745013-59-6
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Antibodies Phase 2
10 Antibodies, Monoclonal Phase 2
11 Anti-Infective Agents Phase 2
12 Antimetabolites Phase 2
13 Antimetabolites, Antineoplastic Phase 2
14 Antiviral Agents Phase 2
15 Endothelial Growth Factors Phase 2
16 Immunoglobulins Phase 2
17 Immunosuppressive Agents Phase 2
18 Mitogens Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2 Sunitinib
2 Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 A Phase II Study of HMPL-504 in Lung Sarcomatoid Carcinoma Recruiting NCT02897479 Phase 2 Savolitinib
4 Pulmonary sarcomatoid_MEDI4736+Treme Recruiting NCT03022500 Phase 2 durvalumab + tremelimumab
5 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

38
Kidney, Skin, Lung, Tongue, Endothelial, Thyroid, Lymph Node

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 302)
# Title Authors Year
1
Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity. ( 28843710 )
2017
2
Spindle cell carcinoma of the mandible: a case report. ( 28808219 )
2017
3
Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports. ( 29075488 )
2017
4
Coexistence of Mediastinal Castleman Disease with Spindle Cell Carcinoma of the Lung. ( 28661181 )
2017
5
Long-term complete response to carboplatin plus paclitaxel combined with bevacizumab in a patient with metastatic spindle cell carcinoma. ( 29153418 )
2017
6
Chromosomal abnormalities of high-grade mucinous tubular and spindle cell carcinoma of the kidney. ( 28656700 )
2017
7
Pulmonary spindle cell carcinoma with unusual morphology: A rare case report and review of the literature. ( 28614235 )
2017
8
Increased 18F-2- Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma: Reply. ( 28525462 )
2017
9
Metaplastic spindle cell carcinoma of the breast in a patient with neurofibromatosis type 1. ( 29139585 )
2017
10
Leukoplakia of buccal mucosa with transformation into spindle cell carcinoma: A rare case report. ( 28479698 )
2017
11
Mucinous tubular and spindle cell carcinoma with a high nuclear grade and micropapillary pattern: A case report. ( 29285359 )
2017
12
Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour. ( 29348963 )
2017
13
Mucinous tubular and spindle cell carcinoma. An uncommon renal neoplasm with favorable prognosis. ( 28196744 )
2017
14
Re: Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. ( 28319504 )
2017
15
Vulvar Carcinosarcoma Composed of Intestinal-type Mucinous Adenocarcinoma Associated With Anaplastic Pleomorphic and Spindle Cell Carcinoma and Heterologous Chondrosarcomatous and Osteosarcomatous Elements: A Case Report and Review of the Literature. ( 28319579 )
2017
16
Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors. ( 28591732 )
2017
17
Renal Mucinous Tubular and Spindle Cell Carcinoma Shows a High Uptake on<sup>18</sup>F-FDG PET/CT. ( 29279490 )
2017
18
Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report. ( 28781811 )
2017
19
Spindle cell carcinoma of the conjunctiva: A rare entity. ( 27380985 )
2016
20
Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. ( 27764039 )
2016
21
Spindle cell carcinoma of the mandible: Clinicopathological and immunohistochemical characteristics. ( 27195215 )
2016
22
Sinonasal spindle cell carcinoma presenting with bilateral visual loss: A case report and review of the literature. ( 27347158 )
2016
23
CT and MR imaging features of mucinous tubular and spindle cell carcinoma of the kidneys. A multi-institutional review. ( 27334016 )
2016
24
Spindle cell carcinoma of the breast: a comprehensive analysis. ( 26830716 )
2016
25
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study. ( 27491291 )
2016
26
Spindle cell carcinoma of the tongue combined with double primary cancer of the thyroid gland: a case report. ( 27595090 )
2016
27
Spindle Cell Carcinoma of the Mandibular Gingiva - A Case Report. ( 27042594 )
2016
28
Bi-allelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. ( 27604489 )
2016
29
Spindle cell carcinoma of the esophagus: A multicenter analysis in comparison with typical squamous cell carcinoma. ( 27631227 )
2016
30
Spindle Cell Carcinoma of Nasal Cavity- A Case Report. ( 27190843 )
2016
31
Comparative study of CT appearances in mucinous tubular and spindle cell carcinoma and collecting duct carcinoma of the kidney. ( 26435393 )
2015
32
Clinicopathological characteristics of kidney mucinous tubular and spindle cell carcinoma. ( 25755810 )
2015
33
A Case of Granulocyte-Colony Stimulating Factor-Producing Spindle Cell Carcinoma of the Breast. ( 25823685 )
2015
34
Wide expression of ZEB1 in sarcomatous component of spindle cell carcinoma of the esophagus. ( 26515382 )
2015
35
Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients. ( 26635898 )
2015
36
Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician. ( 26788392 )
2015
37
Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms undergoing epithelial-mesenchymal transition. ( 25420898 )
2015
38
Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. ( 25785207 )
2015
39
(18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. ( 25589812 )
2015
40
Mucinous tubular and spindle cell carcinoma of the kidney: Diagnosis by fine needle aspiration and review of the literature. ( 26884801 )
2015
41
Expression of p40 and laminin 332 in metaplastic spindle cell carcinoma of the breast compared with other malignant spindle cell tumours. ( 25795733 )
2015
42
Mucinous tubular and spindle cell carcinoma of kidney: A case report of an unusual tumor. ( 26458668 )
2015
43
An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage. ( 26558362 )
2015
44
Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck. ( 26203085 )
2015
45
Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival. ( 25994520 )
2015
46
Spindle cell carcinoma arising at the buccal mucosa: a case report and review of the literature. ( 25547144 )
2015
47
Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. ( 25699980 )
2015
48
Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. ( 25713418 )
2015
49
Cutaneous spindle cell carcinoma misdiagnosed as atypical fibroxanthoma based on immunohistochemical stains. ( 27051790 )
2015
50
Renal mucinous tubular and spindle cell carcinoma: report of four cases and literature review. ( 26045827 )
2015

Variations for Spindle Cell Carcinoma

Cosmic variations for Spindle Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM45765 TP53 skin,leg,carcinoma,squamous cell carcinoma c.987C>A p.T329T 9
2 COSM10863 TP53 skin,leg,carcinoma,squamous cell carcinoma c.833C>T p.P278L 9
3 COSM45114 TP53 skin,leg,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 9
4 COSM573 NRAS skin,scalp,carcinoma,squamous cell carcinoma c.38G>A p.G13D 9
5 COSM521 KRAS skin,scalp,carcinoma,squamous cell carcinoma c.35G>A p.G12D 9
6 COSM554 KRAS skin,scalp,carcinoma,squamous cell carcinoma c.183A>C p.Q61H 9
7 COSM499 HRAS skin,trunk,carcinoma,squamous cell carcinoma c.182A>G p.Q61R 9
8 COSM498 HRAS skin,trunk,carcinoma,squamous cell carcinoma c.182A>T p.Q61L 9
9 COSM12475 CDKN2A skin,leg,carcinoma,squamous cell carcinoma c.238C>T p.R80* 9

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.66 ACTC1 CDH1 DES KRT5 KRT7 MUC1
2
Show member pathways
11.49 DES KRT5 KRT7 VIM
3 11.29 ACTC1 DES VIM
4 10.39 CDH1 CDH16 VIM

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.9 ACTC1 AMACR CDH1 DES ENO2 KRT5
2 extracellular exosome GO:0070062 9.28 ACTC1 CDH1 CDH16 DES ENO2 KRT5
3 intermediate filament GO:0005882 9.26 DES KRT5 KRT7 VIM

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.16 DES VIM
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 MUC1 TP63
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 DES KRT5 VIM
2 identical protein binding GO:0042802 9.1 CDH1 DES PGR SYP TP63 VIM

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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