MCID: SPN032
MIFTS: 42

Spindle Cell Carcinoma malady

Cancer diseases category

Summaries for Spindle Cell Carcinoma

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Disease Ontology:9 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to renal cell carcinoma and merkel cell carcinoma. An important gene associated with Spindle Cell Carcinoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways is Development Slit Robo signaling. The compounds dutp and deoxyribonucleic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, breast and skin, and related mouse phenotypes are liver/biliary system and normal.

Wikipedia:63 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Aliases & Classifications for Spindle Cell Carcinoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 33MeSH, 38NCIt, 55SNOMED-CT
See all sources

Spindle Cell Carcinoma, Aliases & Descriptions:

Name: Spindle Cell Carcinoma 9
Carcinoma, Spindle-Cell 60
 
Carcinoma Spindle Cell 43
Sarcomatoid Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4015
MeSH33 D002277
SNOMED-CT55 23109009, 65692009
NCIt38 C27004

Related Diseases for Spindle Cell Carcinoma

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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma31.4AMACR
2merkel cell carcinoma30.6SYP, MUC1
3giant cell tumor30.4MUC1, ACTC1
4malignant pleural mesothelioma30.3WT1, MUC1
5mesothelioma30.3WT1, ACTC1, MUC1
6sarcoma30.2WT1, ACTC1, MUC1
7melanoma29.7AMACR, ACTC1, SNAI2, KRT18
8rhabdoid tumor29.6WT1, SYP, ACTC1, MUC1
9adenoma29.5AMACR, MUC1, ACTC1, SYP, KRT18
10adenocarcinoma29.1AMACR, MUC1, ACTC1, SYP, KRT18, WT1
11mucinous tubular and spindle cell carcinoma11.0
12nephrogenic adenoma10.5AMACR
13thyroiditis10.5
14fibromatosis10.5
15ganglioglioma10.5SYP
16sarcomatoid squamous cell skin carcinoma10.4
17rectum sarcomatoid carcinoma10.4
18metanephric adenoma10.4WT1
19adenomatoid tumor10.4WT1
20thymus sarcomatoid carcinoma10.4
21prostatitis10.3
22adenosarcoma10.3ACTC1
23choroid plexus papilloma10.3MUC1, SYP
24neuroendocrine carcinoma10.3
25blastoma10.3
26large cell neuroendocrine carcinoma10.3
27spindle cell variant squamous cell breast carcinoma10.3
28esophagitis10.3
29laryngitis10.3
30pulmonary blastoma10.3
31sertoli cell tumor10.3MUC1, SYP
32hemangioblastoma10.3MUC1, SYP
33kidney disease10.2WT1
34renal clear cell carcinoma10.2AMACR, MUC1
35hemangioma10.2ACTC1
36ependymoma10.2MUC1, SYP
37sarcomatoid mesothelioma10.2
38fibrous histiocytoma10.2
39bladder diverticulum10.2
40histiocytoma10.2
41chordoma10.2MUC1, KRT18
42desmoplastic small round cell tumor10.2MUC1, WT1
43sertoli-leydig cell tumor10.2WT1, MUC1
44sex cord-gonadal stromal tumor10.2MUC1, WT1
45pancreatic cancer10.2SYP, MUC1
46endometrial cancer10.1WT1, MUC1
47glomus tumor10.1SYP, ACTC1
48cholangiocarcinoma10.1KRT18, MUC1
49neuroblastoma10.1
50neurofibromatosis, type 110.1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Symptoms for Spindle Cell Carcinoma

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Drugs & Therapeutics for Spindle Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Carcinoma

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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MalaCards organs/tissues related to Spindle Cell Carcinoma:

31
Kidney, Breast, Skin, Lung, Tongue, Thyroid, Lymph node, Pancreas, Liver, Trachea, Eye, Heart, Uterus, Tonsil, Endothelial

Animal Models for Spindle Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5WT1, KRT18, MUC1, AMACR
2MP:00028737.9MUC1, ACTC1, SYP, WT1
3MP:00107687.6WT1, KRT18, SNAI2, ACTC1, AMACR
4MP:00053787.5AMACR, ACTC1, SNAI2, KRT18, WT1

Publications for Spindle Cell Carcinoma

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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Spindle cell carcinoma arising at the buccal mucosa: a case report and review of the literature. (25547144)
2015
2
A Case of Granulocyte-Colony Stimulating Factor-Producing Spindle Cell Carcinoma of the Breast. (25823685)
2015
3
Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. (25713418)
2015
4
Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. (25699980)
2015
5
Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. (25785207)
2015
6
(18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. (25589812)
2015
7
Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. (25013496)
2014
8
Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. (24634155)
2014
9
Management of spindle cell carcinoma of the maxillary sinus: a case report and literature review. (25350698)
2014
10
Spindle cell carcinoma of the breast as complex cystic lesion: a case report. (25009755)
2014
11
Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma. (25114719)
2014
12
Clear cell changes in mucinous tubular and spindle cell carcinoma: cytoplasmic pallor/clearing within tubules, vacuoles or hybrid conventional clear cell carcinoma of kidney? (25120820)
2014
13
The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney: a case report. (23374174)
2013
14
Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. (21684183)
2012
15
Spindle cell carcinoma of the lung. (21308442)
2011
16
A case of esophageal spindle cell carcinoma. (21957183)
2011
17
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (21415004)
2011
18
N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. (21070371)
2011
19
Post irradiation spindle cell carcinoma of tonsillar pillar. (22203850)
2011
20
Clinicopathological and immunohistochemical features of oral spindle cell carcinoma. (20002980)
2010
21
Mucinous tubular and spindle cell carcinoma of the kidney. (20022029)
2010
22
Fine needle aspiration cytology of spindle cell carcinoma of the tongue: a case report with emphasis on the diagnostic difficulties. (18691220)
2010
23
Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. (20730609)
2010
24
Spindle cell lesions--neoplastic or non-neoplastic?: spindle cell carcinoma and other atypical spindle cell lesions of the head and neck. (20614332)
2008
25
Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. (18712413)
2008
26
Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. (17721310)
2007
27
Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. (17098672)
2006
28
A 15-year-old girl with a spindle cell carcinoma of the parotid gland. A diagnostic challenge solved by immunohistochemistry and cytogenetic analysis. (16308263)
2006
29
Renal mucinous and tubular spindle cell carcinoma: a clinicopathological study of 4 cases. (17396379)
2006
30
Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney. (16267782)
2006
31
Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. (17122511)
2006
32
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma. (14767509)
2004
33
Spindle cell carcinoma of the intrahepatic bile duct in a patient with primary sclerosing cholangitis. (14673729)
2003
34
Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. (12047767)
2002
35
So-called carcinosarcoma of the gallbladder; spindle cell carcinoma of the gallbladder: report of a case. (12061703)
2002
36
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
37
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. (11474284)
2001
38
Spindle cell carcinoma of the oral cavity. Report o f a case. (11507539)
2000
39
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
40
Spindle cell carcinoma of the larynx and hypopharynx. (9018257)
1997
41
A combined small cell and spindle cell carcinoma of the lung. Report of a unique case with immunohistochemical and ultrastructural studies. (1335211)
1992
42
Spindle-cell carcinoma of the oral cavity and larynx. Immunohistochemical aspects. (2474578)
1989
43
Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. (2473024)
1989
44
Undifferentiated spindle cell carcinoma of the thyroid in a dog. (3962088)
1986
45
The controversial role of radiotherapy in spindle cell carcinoma (pseudosarcoma) of the head and neck. (3836441)
1985
46
Oral findings of a spindle-cell carcinoma of the maxillary alveolar ridge. (3928707)
1985
47
Metastatic spindle-cell carcinoma. Cytologic features and differential diagnosis. (3859145)
1985
48
Spindle cell carcinoma of the hamster trachea induced by N-methyl-N-nitrosourea. (6837722)
1983
49
Spindle cell carcinoma of the vulva. (7117117)
1982
50
Spindle-cell carcinoma of the laryngopharynx. (720254)
1978

Variations for Spindle Cell Carcinoma

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Cosmic variations for Spindle Cell Carcinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1144150TP53skin,leg,carcinoma,squamous cell carcinoma3

Expression for genes affiliated with Spindle Cell Carcinoma

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Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion58
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.1KRT18, ACTC1

Compounds for genes affiliated with Spindle Cell Carcinoma

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Compounds related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 38)
idCompoundScoreTop Affiliating Genes
1dutp439.7KRT18, SYP
2deoxyribonucleic acid439.6WT1, AMACR
3lithium43 49 24 1212.6SYP, MUC1
4nash439.4KRT18, ACTC1
5gold439.4SYP, KRT18, MUC1
6ethanol43 49 24 1212.3MUC1, SYP, KRT18
7tetracycline43 1210.2WT1, KRT18
8s 100439.2ACTC1, MUC1, SYP
9reticulin439.2MUC1, ACTC1, SYP
10mucicarmine439.2SYP, MUC1, ACTC1
11biotin43 24 1211.2AMACR, MUC1, ACTC1
12butyrate439.1KRT18, WT1, MUC1
13thymidine43 2410.0WT1, MUC1, KRT18
14oligonucleotide439.0KRT18, AMACR, WT1
15cholesterol43 28 24 1211.9MUC1, SYP, AMACR
16lipid438.9SYP, MUC1, AMACR, KRT18
17cysteine438.9SYP, MUC1, AMACR, WT1
18ribonucleic acid438.9MUC1, ACTC1, WT1
19forskolin43 49 1210.8WT1, KRT18, SYP, MUC1
20nitric oxide43 24 1210.8WT1, SYP, MUC1, KRT18
21zinc43 249.7WT1, SNAI2, AMACR, KRT18
22formaldehyde43 249.6KRT18, SYP, MUC1, ACTC1
23glycogen43 249.6ACTC1, MUC1, KRT18, SYP
24b 723438.6WT1, MUC1, ACTC1, SYP
25glucose438.5AMACR, KRT18, MUC1, ACTC1
26serine438.5MUC1, SYP, KRT18, WT1
27matrigel438.5KRT18, SNAI2, MUC1, ACTC1
28steroid438.4KRT18, WT1, ACTC1, SYP
29hematoxylin438.3KRT18, MUC1, AMACR, SYP, ACTC1
30dexamethasone43 49 28 1211.3KRT18, ACTC1, MUC1, AMACR, SYP
31creatinine438.0WT1, KRT18, SYP, ACTC1, MUC1
32vegf438.0MUC1, KRT18, SYP, ACTC1, WT1
33paraffin437.7KRT18, AMACR, MUC1, ACTC1, SYP, WT1
34progesterone43 28 59 24 1211.7KRT18, SYP, ACTC1, MUC1, AMACR, WT1
35testosterone43 59 24 1210.7WT1, KRT18, SYP, ACTC1, MUC1, AMACR
36retinoic acid43 248.7AMACR, WT1, KRT18, SYP, ACTC1, MUC1
37estrogen437.2ACTC1, MUC1, KRT18, AMACR, SYP, SNAI2
38tyrosine437.1SYP, AMACR, MUC1, ACTC1, KRT18, WT1

GO Terms for genes affiliated with Spindle Cell Carcinoma

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Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.5SNAI2, MUC1
2cytoplasmGO:00057376.9WT1, KRT18, SNAI2, ACTC1, MUC1, AMACR

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:00430668.5WT1, KRT18, ACTC1

Products for genes affiliated with Spindle Cell Carcinoma

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Sources for Spindle Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet