MCID: SPN032
MIFTS: 43

Spindle Cell Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

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Aliases & Descriptions for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 11 13
Carcinoma, Spindle-Cell 67
 
Carcinoma Spindle Cell 49
Sarcomatoid Carcinoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:4015
MeSH38 D002277
SNOMED-CT61 23109009, 65692009
NCIt44 C27004

Summaries for Spindle Cell Carcinoma

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Disease Ontology:11 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to pleomorphic carcinoma and renal cell carcinoma. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways are Striated Muscle Contraction and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include kidney, skin and lung, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:70 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic carcinoma29.0KRT14, KRT5, PGR
2renal cell carcinoma28.9AMACR, CDH1, CDH16, KRT8, MUC1, VIM
3rectum sarcomatoid carcinoma11.9
4thymus sarcomatoid carcinoma11.9
5sarcomatoid squamous cell skin carcinoma11.2
6sarcomatoid transitional cell carcinoma10.9
7sarcomatoid renal cell carcinoma10.9
8sarcomatoid penile squamous cell carcinoma10.8
9distal monosomy 7q3610.7MUC1, VIM
10transitional meningioma10.7MUC1, VIM
11lymphangiomatosis10.7ACTC1, VIM
12myxoid liposarcoma of the ovary10.7ACTC1, VIM
13iridogoniodysgenesis and skeletal anomalies10.7ACTC1, VIM
14pediculus humanus capitis infestation10.7MUC1, VIM
15subependymal giant cell astrocytoma10.7MUC1, VIM
16placental site trophoblastic tumor10.6ACTC1, MUC1
17xq12-q13.3 duplication syndrome10.6ACTC1, DES
18middle ear squamous cell carcinoma10.6CDH1, VIM
19syringoma10.6MUC1, VIM
20breast metaplastic carcinoma10.6MUC1, PGR
21harding ataxia10.6DES, VIM
22plethora of newborn10.6CDH1, MUC1
23malignant peritoneal solitary fibrous tumor10.6ACTC1, VIM
24glottis verrucous carcinoma10.6MUC1, PGR
25absence of fingerprints congenital milia10.6DES, VIM
26urethra squamous cell carcinoma10.6CDH1, VIM
27endometriosis of pelvic peritoneum10.6MUC1, PGR
28adenocarcinoma in situ10.6MUC1, PGR
29combined thymoma10.6DES, MUC1
30pancreatic delta cell neoplasm10.6DES, VIM
31subacute leukemia10.6DES, MUC1
32simple partial epilepsy10.6ACTC1, PGR
33serous surface papilloma10.6MUC1, PGR
34malignant adenofibroma10.6DES, VIM
35non-gestational choriocarcinoma10.5PGR, VIM
36white platelet syndrome10.5DES, MUC1
37hing torack dowston syndrome10.5MUC1, SYP
38fraxf syndrome10.5SYP, VIM
39pura syndrome10.5ACTC1, DES
40pleuropulmonary blastoma type 210.5ACTC1, DES
41sm-ahnmd10.5SYP, VIM
42ovarian surface papilloma10.5AMACR, MUC1, VIM
43focal facial dermal dysplasia10.5ACTC1, SYP
44skin sarcoma10.5ACTC1, MUC1, VIM
45breast malignant phyllodes tumor10.5CDH1, MUC1
46ovarian cystadenocarcinoma10.5ACTC1, MUC1, VIM
47dysembryoplastic neuroepithelial tumor10.5DES, PGR
48apocrine adenocarcinoma10.5MUC1, PGR
49gallbladder signet ring cell adenocarcinoma10.5CDH1, SYP
50dens in dente and palatal invaginations10.5ACTC1, MUC1, VIM

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Symptoms for Spindle Cell Carcinoma

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Drugs & Therapeutics for Spindle Cell Carcinoma

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Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Sunitinibapproved, investigationalPhase 2500341031-54-7, 557795-19-45329102
Synonyms:
(2S)-2-hydroxybutanedioic acid
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
326914-13-0
341031-54-7
5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE
557795-19-4
AC1NS62J
AC1O5CMQ
AKOS005145765
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
CHEBI:38940
CHEBI:550864
CHEMBL1567
CHEMBL535
CID5329102
CID6456015
D06402
D08552
DB01268
DB07417
EN002687
FT-0083555
FT-0083556
I01-1229
K00588a
KS-5022
LS-186078
LS-187023
LS-187648
MolPort-003-986-763
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
 
NSC736511
NSC750690
PDGF TK antagonist
PHA-290940AD
PNU-290940AD
S1042_Selleck
ST51053712
SU 011248
SU 11248
SU-010398
SU-011248 L-malate salt
SU-11248
SU-11248 L-malate salt
SU-11248J
SU-12662
SU010398
SU011248
SU011248 L-malate salt
SU11248
Su-011248
Sunitanib
Sunitinib
Sunitinib (INN)
Sunitinib (free base)
Sunitinib malate
Sunitinib malate (JAN/USAN)
Sunitinib malate [USAN]
Sunitinibum
Sutent
Sutent (TN)
Sutent, SU-11248
TL8002546
UNII-LVX8N1UT73
UNII-V99T50803M
sunitinib
sunitinibum
2
Bevacizumabapproved, investigationalPhase 21968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3
GemcitabineapprovedPhase 2197495058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
4
Capecitabineapproved, investigationalPhase 21296154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
5
nivolumabapprovedPhase 2326946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
6
CisplatinapprovedPhase 2, Phase 1269015663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)
7
SuccinylcholineapprovedPhase 2161306-40-15314
Synonyms:
2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM)
2,2'-[(1,4-DIOXOBUTANE-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
2ha2
2ha6
306-40-1
4-04-00-01451 (Beilstein Handbook Reference)
541-19-5 (diiodide)
55-94-7 (dibromide)
71-27-2 (dichloride)
AC1L1K2T
Anectine
BRN 1805311
C07546
C14H30N2O4
CHEBI:45652
CHEMBL703
CID5314
Choline, succinate (2:1) (ester)
Choline, succinate (ester)
DB00202
Diacetylcholine
Dicholine succinate
Ditilin
Ditiline
HMS2090P14
HSDB 3254
InChI=1/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
L000926
LS-53328
Listenon
 
Lopac-S-8251
Lopac0_001080
Lysthenon
MolPort-002-964-486
NCGC00015971-01
NCGC00015971-03
NCGC00162336-01
Quelicin
Quelicin Preservative Free
SCK
ST50437287
STK177290
Scoline
Succicuran
Succinic acid, diester with choline
Succinic acid, diester with choline chloride
Succinocholine
Succinoylcholine
Succinyl choline
Succinylbischoline
Succinylcholine
Succinylcholine Chloride
Succinyldicholine
Sucostrin
Suxamethonium
Suxamethonium chloride
UNII-J2R869A8YF
ZINC01530820
succinylcholine
succinyldicholine
trimethyl-[2-[4-oxo-4-(2-trimethylazaniumylethoxy)butanoyl]oxyethyl]azanium diio
trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium
8
Paclitaxelapproved, vet_approvedPhase 2275833069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
9Angiogenesis InhibitorsPhase 24143
10Angiogenesis Modulating AgentsPhase 24072
11Immunosuppressive AgentsPhase 212770
12MitogensPhase 21526
13ImmunoglobulinsPhase 26045
14AntibodiesPhase 26045
15Antibodies, MonoclonalPhase 23795
16Endothelial Growth FactorsPhase 2362
17Anti-Infective AgentsPhase 221402
18AntimetabolitesPhase 211774
19Antiviral AgentsPhase 29732
20Antimetabolites, AntineoplasticPhase 27171
21Peripheral Nervous System AgentsPhase 222776
22Neuromuscular Depolarizing AgentsPhase 2135
23Neuromuscular Blocking AgentsPhase 2414
24Neuromuscular AgentsPhase 21129
25Antineoplastic Agents, PhytogenicPhase 25420
26Albumin-Bound PaclitaxelPhase 22757
27
tremelimumabPhase 294
Synonyms:
206
CP675
 
CP675206
Ticilimumab
tremelimumab
28Antimitotic AgentsPhase 25498

Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell CarcinomaUnknown statusNCT01219751Phase 2
2Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell CarcinomaCompletedNCT00496587Phase 2
3Nivolumab and Ipilimumab in Treating Patients With Rare TumorsRecruitingNCT02834013Phase 2
4Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone SurgeryRecruitingNCT02734537Phase 2
5A Phase I/II Trial of Crolibulin (EPC2407) Plus Cisplatin in Adults With Solid Tumors With a Focus on Anaplastic Thyroid Cancer (ATC)Active, not recruitingNCT01240590Phase 1, Phase 2
6A Phase II Study of HMPL-504 in Lung Sarcomatoid CarcinomaNot yet recruitingNCT02897479Phase 2
7Pulmonary sarcomatoid_MEDI4736+TremeNot yet recruitingNCT03022500Phase 2
8Alisertib in Chemotherapy-pretreated Urothelial CancerNot yet recruitingNCT02109328Phase 2

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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MalaCards organs/tissues related to Spindle Cell Carcinoma:

35
Kidney, Skin, Lung, Thyroid, Tongue, Endothelial, Lymph node

Animal Models for Spindle Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.6ACTC1, CDH1, DES, KRT8, PGR, TP63
2MP:00053767.5ACTC1, AMACR, CDH1, DES, KRT14, KRT8
3MP:00107686.3ACTC1, AMACR, CDH1, DES, KRT14, KRT5

Publications for Spindle Cell Carcinoma

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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Spindle Cell Carcinoma of the Mandibular Gingiva - A Case Report. (27042594)
2016
2
Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival. (25994520)
2015
3
A Case of Granulocyte-Colony Stimulating Factor-Producing Spindle Cell Carcinoma of the Breast. (25823685)
2015
4
Wide expression of ZEB1 in sarcomatous component of spindle cell carcinoma of the esophagus. (26515382)
2015
5
Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. (25699980)
2015
6
Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. (25785207)
2015
7
(18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. (25589812)
2015
8
Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck. (26203085)
2015
9
Osseous Metaplasia in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Case of Massive, Bilateral Tumors. (26347846)
2015
10
An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage. (26558362)
2015
11
Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. (24634155)
2014
12
Spindle cell carcinoma of the breast as complex cystic lesion: a case report. (25009755)
2014
13
Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma. (25114719)
2014
14
Clear cell changes in mucinous tubular and spindle cell carcinoma: cytoplasmic pallor/clearing within tubules, vacuoles or hybrid conventional clear cell carcinoma of kidney? (25120820)
2014
15
Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney: A Retrospective Detailed Study of Radiologic, Pathologic and Clinical Outcomes. (25395040)
2014
16
The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney: a case report. (23374174)
2013
17
Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature. (24330589)
2013
18
Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. (21684183)
2012
19
A case of esophageal spindle cell carcinoma. (21957183)
2011
20
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (21415004)
2011
21
Post irradiation spindle cell carcinoma of tonsillar pillar. (22203850)
2011
22
Clinicopathological and immunohistochemical features of oral spindle cell carcinoma. (20002980)
2010
23
Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. (20730609)
2010
24
Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature. (19805959)
2009
25
Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. (18712413)
2008
26
Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma. (18670354)
2008
27
Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma. (18283489)
2008
28
Mucinous tubular and spindle cell carcinoma of the kidney: cytopathologic findings. (17703454)
2007
29
Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. (17098672)
2006
30
Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney. (16267782)
2006
31
Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. (17122511)
2006
32
Mucinous tubular and spindle cell carcinoma of the kidney with neuroendocrine differentiation: report of two cases. (16482997)
2006
33
Spindle cell carcinoma of breast with neuroendocrine differentiation]. (16608642)
2006
34
Cutaneous spindle cell carcinoma following basal cell carcinoma. (15677971)
2005
35
Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. (12047767)
2002
36
So-called carcinosarcoma of the gallbladder; spindle cell carcinoma of the gallbladder: report of a case. (12061703)
2002
37
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
38
Spindle cell carcinoma of the larynx and hypopharynx. (9018257)
1997
39
Spindle cell carcinoma of the breast: a case report and an immunohistochemical study including p53 and Ki-67 expression. (9211529)
1997
40
Spindle cell carcinoma of the conjunctiva. (7536697)
1995
41
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. (7689080)
1993
42
A combined small cell and spindle cell carcinoma of the lung. Report of a unique case with immunohistochemical and ultrastructural studies. (1335211)
1992
43
Proliferating trichilemmal cyst with spindle cell carcinoma. (1700885)
1990
44
Pathologic quiz case 1. Spindle cell carcinoma (spindle cell variant of squamous cell carcinoma). (2294936)
1990
45
Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. (2473024)
1989
46
Spindle cell carcinoma of the renal pelvis. Immunohistochemical and ultrastructural study of a case demonstrating coexpression of keratin and vimentin intermediate filaments. (2468323)
1989
47
Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumors and comparison with seven monophasic spindle-cell tumors. (2430474)
1986
48
Spindle cell carcinoma of the hamster trachea induced by N-methyl-N-nitrosourea. (6837722)
1983
49
Spindle cell carcinoma of the vulva. (7117117)
1982
50
Spindle-cell carcinoma of the laryngopharynx. (720254)
1978

Variations for Spindle Cell Carcinoma

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Cosmic variations for Spindle Cell Carcinoma:

8 (show all 18)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM10988TP53skin,face,carcinoma,squamous cell carcinomac.772G>Ap.E258K9
2COSM43588TP53skin,face,carcinoma,squamous cell carcinomac.740A>Cp.N247T9
3COSM520KRASskin,face,carcinoma,squamous cell carcinomac.35G>Tp.G12V9
4COSM585NRASskin,face,carcinoma,squamous cell carcinomac.183A>Tp.Q61H9
5COSM43582TP53skin,face,carcinoma,squamous cell carcinomac.454C>Tp.P152S9
6COSM564NRASskin,face,carcinoma,squamous cell carcinomac.35G>Ap.G12D9
7COSM483HRASskin,face,carcinoma,squamous cell carcinomac.35G>Tp.G12V9
8COSM498HRASskin,face,carcinoma,squamous cell carcinomac.182A>Tp.Q61L9
9COSM521KRASskin,hand,carcinoma,squamous cell carcinomac.35G>Ap.G12D9
10COSM10726TP53skin,face,carcinoma,squamous cell carcinomac.856G>Ap.E286K9
11COSM10656TP53skin,face,carcinoma,squamous cell carcinomac.742C>Tp.R248W9
12COSM17489PTCH1skin,face,carcinoma,squamous cell carcinomac.3724G>Ap.E1242K9
13COSM10939TP53skin,face,carcinoma,squamous cell carcinomac.832C>Tp.P278S9
14COSM43665TP53skin,face,carcinoma,squamous cell carcinomac.746G>Cp.R249T9
15COSM11081TP53skin,face,carcinoma,squamous cell carcinomac.733G>Tp.G245C9
16COSM574NRASskin,face,carcinoma,squamous cell carcinomac.38G>Tp.G13V9
17COSM10733TP53skin,face,carcinoma,squamous cell carcinomac.574C>Tp.Q192*9
18COSM10654TP53skin,face,carcinoma,squamous cell carcinomac.637C>Tp.R213*9

Expression for genes affiliated with Spindle Cell Carcinoma

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Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ACTC1, DES, VIM
2
Show member pathways
8.1DES, KRT14, KRT5, KRT8, VIM
38.0ACTC1, CDH1, DES, KRT5, KRT8, VIM

GO Terms for genes affiliated with Spindle Cell Carcinoma

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Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.4KRT14, KRT5, KRT8
2intermediate filamentGO:00058828.7DES, KRT14, KRT5, KRT8, VIM
3cytoplasmGO:00057376.2ACTC1, AMACR, CDH1, DES, KRT14, KRT5
4extracellular exosomeGO:00700626.1ACTC1, CDH1, CDH16, DES, KRT14, KRT5

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1MUC1, TP63
2intermediate filament organizationGO:00451099.6DES, VIM
3hemidesmosome assemblyGO:00315819.5KRT14, KRT5
4muscle filament slidingGO:00300499.5ACTC1, DES, VIM
5epidermis developmentGO:00085449.1KRT14, KRT5, TP63
6epithelial cell differentiationGO:00308559.0KRT14, MUC1, TP63

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filament bindingGO:19902549.8KRT14, VIM
2scaffold protein bindingGO:00971109.0KRT5, KRT8, VIM
3structural constituent of cytoskeletonGO:00052008.6DES, KRT14, KRT5, VIM

Sources for Spindle Cell Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet