MCID: SPN032
MIFTS: 51

Spindle Cell Carcinoma malady

Cancer category

Summaries for Spindle Cell Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to spindle cell sarcoma and squamous cell carcinoma. An important gene associated with Spindle Cell Carcinoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cytoskeletal Signaling. The compounds glutamate and forskolin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, heart and kidney, and related mouse phenotypes are cardiovascular system and normal.

Wikipedia:64 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Aliases & Classifications for Spindle Cell Carcinoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

spindle cell carcinoma 8
carcinoma, spindle-cell 61
carcinoma spindle cell 45
sarcomatoid carcinoma 8


External Ids:

Disease Ontology8 DOID:4015
MeSH35 D002277
SNOMED-CT57 23109009, 65692009
NCIt40 C27004

Related Diseases for Spindle Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1spindle cell sarcoma31.0S100B, DES, MUC1, KRT7, ACTC1
2squamous cell carcinoma30.8TWIST1, ENO2, ACTC1, KRT7, KRT18, KRT1
3papillary carcinoma30.6SYP, CHGA, MUC1, KRT18, KRT7, ACTC1
4neuroendocrine carcinoma30.6S100B, SYP, CHGA, MUC1, KRT1, KRT18
5fibromatosis30.6S100A1, DES, CD34, ACTC1
6bladder carcinoma30.3KRT18
7large cell carcinoma30.3SYP, CHGA, KRT7, ENO2
8fibrous histiocytoma30.2ACTC1, CD34, DES, S100B
9renal clear cell carcinoma30.1AMACR, S100A1, MUC1, CDH16, KRT7
10basal cell carcinoma30.1CD34, KRT7, ACTC1
11adenoid cystic carcinoma30.1S100B, S100A1, MUC1, KRT7, ACTC1
12granular cell tumor30.1S100B, S100A1, DES, SYP, ENO2
13transitional cell carcinoma30.1KRT18, KRT7, ENO2
14adenoma30.1ENO2, ACTC1, KRT7, KRT18, AMACR, S100A1
15adenocarcinoma30.1SYP, CHGA, MUC1, CD34, KRT1, KRT18
16thymic carcinoma30.0SYP, MUC1, KRT18, KRT7
17rhabdoid tumor30.0DES, SYP, MUC1, ACTC1, WT1
18bladder sarcoma10.5
19papillary renal cell carcinoma10.4
20pleomorphic carcinoma10.4
21papillary renal carcinoma10.4
22bile duct carcinoma10.4
23rectum sarcomatoid carcinoma10.3
24sarcomatoid mesothelioma10.3
25thymus sarcomatoid carcinoma10.3
26sarcomatoid squamous cell skin carcinoma10.3
27blastoma10.2
28conjunctiva squamous cell carcinoma10.2
29lung combined large cell neuroendocrine carcinoma10.2
30small cell carcinoma10.2
31spindle cell variant squamous cell breast carcinoma10.2
32trachea carcinoma10.2
33mucinous tubular and spindle cell carcinoma10.2
34bone carcinoma10.2
35bladder diverticulum10.2
36bladder squamous cell carcinoma10.2
37small intestinal sarcoma10.2
38bullous pemphigoid10.1
39pancreas sarcoma10.1
40sarcomatoid renal cell carcinoma10.1
41acute t cell leukemia10.1
42breast myoepithelial carcinoma10.1
43nasopharynx carcinoma10.1
44sarcomatoid transitional cell carcinoma10.1
45lung giant cell carcinoma10.1
46verrucous carcinoma10.1
47sclerosing cholangitis10.1
48granular cell carcinoma10.1
49larynx verrucous carcinoma10.1
50breast adenoid cystic carcinoma10.1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Clinical Features for Spindle Cell Carcinoma

Drugs & Therapeutics for Spindle Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Spindle Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Spindle Cell Carcinoma

Search NIH Clinical Center for Spindle Cell Carcinoma

Search CenterWatch for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Spindle Cell Carcinoma:

33
Lymph node, Heart, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Uterus, Tonsil, Endothelial, Tongue, Trachea

Animal Models for Spindle Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.4WT1, BMP4, SNAI1, DES, CHGA, ACTC1
2MP:00028739.1S100B, S100A1, WT1, BMP4, SNAI1, SYP
3MP:00107688.8TWIST1, AMACR, WT1, BMP4, SNAI1, SNAI2

Publications for Spindle Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Sarcomatoid (spindle cell) carcinoma of the pancreas: A case report and review of the literature. (24348857)
2014
2
The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney: a case report. (23374174)
2013
3
Pigmented mucoepidermoid carcinoma with spindle cell differentiation. (24275356)
2013
4
Spindle cell carcinoma progressed from transitional cell carcinoma of the urinary bladder. (22295151)
2012
5
Rare renal tumor--mucinous tubular and spindle cell carcinoma. (22395517)
2012
6
Renal mucinous tubular and spindle cell carcinoma with an aorto-caval mass mimicking metastatic lymphadenopathy. (22632991)
2012
7
Expression of KRT7 and WT1 differentiates precursor lesions of Wilms' tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas. (22382985)
2012
8
A case of esophageal spindle cell carcinoma. (21957183)
2011
9
Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature. (19805959)
2009
10
Aggressive high-grade mucinous tubular and spindle cell carcinoma. (19442792)
2009
11
Renal cell carcinoma with extensive clear cell change sharing characteristics of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma. (19712140)
2009
12
Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change. (18941398)
2009
13
A case of renal mucinous tubular and spindle cell carcinoma. (19682107)
2009
14
Spindle cell lesions--neoplastic or non-neoplastic?: spindle cell carcinoma and other atypical spindle cell lesions of the head and neck. (20614332)
2008
15
Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma. (18670354)
2008
16
A spindle cell carcinoma presenting with osseous metaplasia in the gingiva: a case report with immunohistochemical analysis. (19040765)
2008
17
Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. (17721310)
2007
18
Right maxillary sinus sarcomatoid carcinoma (sarcomatoid/spindle cell carcinoma). (17666274)
2007
19
Immunophenotype and cytogenetics of mucinous tubular and spindle cell carcinoma of the kidney. (18459456)
2007
20
Spindle cell carcinoma of the external auditory meatus with intracranial extension: histological, immunohistochemical and electron microscopic evaluation. (17364339)
2007
21
Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells. (16625096)
2006
22
A 59-year-old woman with a spindle cell lesion of the breast. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. (16683904)
2006
23
Spindle cell carcinoma of the larynx with actinomyces chondritis of the larynx and trachea. (16455393)
2006
24
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. (16776716)
2006
25
Lymphoepithelioma-like carcinoma of the skin with spindle cell differentiation. (15953375)
2005
26
Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors. (15848743)
2005
27
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
28
A case of spindle cell carcinoma of the breast--long survival achieved by multiple surgical treatment. (11668247)
2001
29
Extensive F-18 FDG uptake in metastatic spindle cell carcinoma of the lung. (11139069)
2001
30
Spindle cell carcinoma of the pancreas. (10982621)
2000
31
Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide. (10669709)
2000
32
Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. (10366152)
1999
33
Spindle cell carcinoma of the breast: a case report and an immunohistochemical study including p53 and Ki-67 expression. (9211529)
1997
34
Spindle cell carcinoma of the breast. (9070341)
1997
35
Invasive spindle cell carcinoma of the conjunctiva. (9046272)
1997
36
Squamous spindle cell carcinoma of the conjunctiva. Fatal outcome of a plerygium-like lesion. (8751131)
1995
37
Undifferentiated spindle cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and flow cytometric study of 11 cases. (8276377)
1993
38
Spindle cell neoplasms coexpressing cytokeratin and vimentin (metaplastic squamous cell carcinoma). (1385501)
1992
39
Lymph node metastasis in spindle cell carcinoma arising in odontogenic cyst. Report of a case. (2003016)
1991
40
Histological types of spindle cell carcinoma of the cornea and conjunctiva. A clinicopathologic report of 8 patients with ultrastructural and immunohistochemical findings in three tumors. (2125913)
1990
41
Spindle-cell carcinoma of the oral cavity and larynx. Immunohistochemical aspects. (2474578)
1989
42
Spindle cell carcinoma of oral mucosa: case report with immunoperoxidase and electron microscopic studies. (3546639)
1987
43
Spindle-cell carcinoma of the aerodigestive tract. An immunohistochemical analysis of 21 cases. (2437812)
1987
44
Undifferentiated spindle cell carcinoma of the thyroid in a dog. (3962088)
1986
45
The controversial role of radiotherapy in spindle cell carcinoma (pseudosarcoma) of the head and neck. (3836441)
1985
46
Anaplastic giant and spindle-cell carcinoma of the thyroid: a different therapeutic approach. (7370924)
1980
47
Proceedings of the tumor board of the Children's Hospital of Philadelphia: Spindle-cell carcinoma of the palate. (723795)
1978
48
Combined therapy for undifferentiated giant and spindle cell carcinoma of the thyroid. (855660)
1977
49
Spindle cell carcinoma of the larynx. (1139427)
1975
50
A limbal spindle-cell carcinoma. (5582831)
1967

Genetic Variations for Spindle Cell Carcinoma

Expression for genes affiliated with Spindle Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

Sources:
12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KRT1, KRT18, KRT7
29.9ACTC1, KRT7, KRT18, DES
39.9TWIST1, SNAI2, SNAI1, BMP4
4
Hide members
9.5BMP4, SNAI1, SNAI2, DES, MUC1, CDH16

Compounds for genes affiliated with Spindle Cell Carcinoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1glutamate4510.5AMACR
2forskolin45 50 1112.5ENO2, KRT18, WT1
3orcein4510.4S100B, DES, ACTC1
4smcc4510.4SYP, CHGA, ENO2
5dexamethasone45 50 29 1113.3AMACR, S100B, KRT18, ENO2
6creatinine4510.3WT1, SYP, CHGA, KRT18, ACTC1
7toluidine4510.3S100A1, DES, ENO2
8l-amino acid4510.3S100B, SYP, CHGA, ENO2
9etoposide45 50 60 1113.2S100B, WT1, CHGA
10glycogen45 2411.2SYP, CHGA, KRT18, KRT7, ACTC1
11glucose4510.2AMACR, MUC1, KRT18, KRT7, ACTC1
12gold4510.2DES, SYP, CHGA, MUC1, KRT18
13acetylcholine45 50 29 11 2414.2S100A1, SYP, CHGA, ENO2
14dbc-amp4510.2ENO2, SYP, BMP4, S100B
15dopamine45 29 11 2413.1BMP4, CHGA, KRT18, ENO2
16biotin45 11 2412.1AMACR, S100A1, DES, MUC1, KRT1, ACTC1
17streptavidin4510.1KRT7, DES, AMACR
18serine4510.1S100B, WT1, DES, SYP, KRT1
19acth4510.1S100B, SYP, CHGA, MUC1, ENO2
20catecholamine4510.0ENO2, CHGA, SYP, S100B
21steroid4510.0WT1, BMP4, DES, SYP, KRT1, KRT18
22ribonucleic acid4510.0ENO2, ACTC1, MUC1, CHGA, BMP4, WT1
23mucicarmine4510.0MUC1, SYP, DES, S100A1, S100B, KRT7
24s 1004510.0ENO2, ACTC1, MUC1, CHGA, SYP, DES
2512-o-tetradecanoylphorbol 13-acetate4510.0KRT1, CD34, MUC1, CHGA, DES, WT1
26reticulin459.9ACTC1, KRT7, CD34, MUC1, SYP, DES
27matrigel459.9BMP4, SNAI2, CHGA, MUC1, KRT18, KRT7
28silver459.9S100A1, DES, SYP, CHGA, CD34, ENO2
29bromodeoxyuridine459.9S100B, BMP4, DES, CHGA, KRT1, KRT18
30ethanol45 50 11 2412.9S100B, DES, SYP, MUC1, KRT18
31threonine459.8S100B, WT1, BMP4, DES, MUC1, KRT1
32b 723459.7ACTC1, KRT7, MUC1, CHGA, SYP, DES
33thymidine45 2410.7S100B, WT1, BMP4, DES, MUC1, CD34
34iron45 2410.7S100B, S100A1, BMP4, DES, KRT18, KRT7
35adenylate459.7AMACR, S100B, BMP4, DES, CHGA, ENO2
36formaldehyde45 2410.7S100B, DES, SYP, CHGA, MUC1, KRT18
37cysteine459.7AMACR, S100B, S100A1, WT1, BMP4, DES
38norepinephrine45 11 2411.7S100B, DES, SYP, CHGA, ENO2
39lipid459.6AMACR, S100B, SYP, CHGA, MUC1, KRT1
40nitric oxide45 11 2411.5S100B, S100A1, WT1, BMP4, DES, SYP
41zinc45 2410.4AMACR, S100B, S100A1, WT1, BMP4, SNAI1
42testosterone45 60 11 2412.3SYP, DES, WT1, S100B, AMACR, CHGA
43vegf459.2SYP, DES, BMP4, WT1, S100B, CHGA
44oxygen45 2410.2S100B, DES, CHGA, MUC1, KRT18, ACTC1
45calcium45 50 11 2412.2DES, BMP4, S100A1, S100B, AMACR, SYP
46hematoxylin459.1CD34, MUC1, CHGA, SYP, DES, S100A1
47paraffin459.0CD34, MUC1, CHGA, SYP, DES, WT1
48retinoic acid45 249.8ENO2, ACTC1, KRT7, KRT18, KRT1, CD34
49progesterone45 60 29 11 2412.8SYP, DES, BMP4, WT1, S100A1, S100B
50tyrosine458.6TWIST1, S100A1, S100B, AMACR, WT1, BMP4

GO Terms for genes affiliated with Spindle Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.1KRT7, KRT18, DES
2keratin filamentGO:0450959.8KRT1, KRT18, KRT7
3cytoplasmGO:0057378.8ACTC1, AMACR, S100B, WT1, SNAI1, SNAI2

Biological processes related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of vitamin D biosynthetic processGO:01095710.3SNAI2, SNAI1
2negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.3TWIST1, SNAI2, SNAI1
3cartilage morphogenesisGO:06053610.2SNAI2, SNAI1
4negative regulation of chondrocyte differentiationGO:03233110.2SNAI2, BMP4
5cranial suture morphogenesisGO:06036310.2BMP4, TWIST1
6osteoblast differentiationGO:00164910.1BMP4, SNAI1, SNAI2, TWIST1
7regulation of tight junction assemblyGO:200081010.1SNAI2, SNAI1
8negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageGO:19022309.9SNAI2, SNAI1
9negative regulation of transcription from RNA polymerase II promoterGO:0001229.8S100A1, WT1, BMP4, SNAI1, SNAI2, TWIST1

Molecular functions related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.2S100A1, S100B

Products for genes affiliated with Spindle Cell Carcinoma

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  • Proteins
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Sources for Spindle Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet