MCID: SPN032
MIFTS: 49

Spindle Cell Carcinoma malady

Cancer diseases category
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Summaries for Spindle Cell Carcinoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to sarcoma and neuroendocrine carcinoma. An important gene associated with Spindle Cell Carcinoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways is Development Slit Robo signaling. The compounds dutp and deoxyribonucleic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and breast, and related mouse phenotypes are liver/biliary system and normal.

Wikipedia:65 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Aliases & Classifications for Spindle Cell Carcinoma

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8Disease Ontology, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell carcinoma 8
carcinoma, spindle-cell 62
carcinoma spindle cell 45
sarcomatoid carcinoma 8


External Ids:

Disease Ontology8 DOID:4015
MeSH35 D002277
SNOMED-CT58 23109009, 65692009
NCIt40 C27004

Related Diseases for Spindle Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.5ACTC1, MUC1, WT1
2neuroendocrine carcinoma30.4SYP, MUC1, KRT18
3giant cell tumor30.3MUC1, ACTC1
4adenoid cystic carcinoma30.2ACTC1, MUC1
5malignant pleural mesothelioma30.1WT1, MUC1
6lung adenocarcinoma30.1AMACR, KRT18, MUC1
7bladder carcinoma30.1KRT18, ACTC1
8malignant mesothelioma30.1MUC1, WT1, SNAI2
9melanoma30.1KRT18, AMACR, SNAI2, ACTC1
10adenoma30.0ACTC1, SYP, MUC1, AMACR, KRT18
11rhabdoid tumor30.0WT1, ACTC1, SYP, MUC1
12adenocarcinoma29.9MUC1, AMACR, ACTC1, SYP, KRT18, WT1
13mucinous tubular and spindle cell carcinoma11.0
14renal cell carcinoma10.5
15thyroiditis10.5
16sarcomatoid squamous cell skin carcinoma10.4
17papillary renal cell carcinoma10.4
18fibromatosis10.4
19rectum sarcomatoid carcinoma10.4
20thymus sarcomatoid carcinoma10.3
21blastoma10.3
22large cell neuroendocrine carcinoma10.3
23spindle cell variant squamous cell breast carcinoma10.3
24esophagitis10.3
25laryngitis10.3
26pulmonary blastoma10.3
27sarcomatoid mesothelioma10.2
28fibrous histiocytoma10.2
29bladder diverticulum10.2
30histiocytoma10.2
31prostatitis10.2
32granular cell tumor10.1
33sarcomatoid transitional cell carcinoma10.1
34bullous pemphigoid10.1
35tonsillitis10.1
36adenoiditis10.1
37sarcomatoid renal cell carcinoma10.1
38pleomorphic carcinoma10.1
39small cell carcinoma10.1
40verrucous carcinoma10.1
41sclerosing cholangitis10.1
42basal cell carcinoma10.1
43cervicitis10.1
44cholangitis10.1
45follicular adenoma10.1
46hepatitis10.1
47leukemia10.1
48lymphoblastic leukemia10.1
49neuroblastoma10.1
50osteomyelitis10.1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Symptoms for Spindle Cell Carcinoma

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Drugs & Therapeutics for Spindle Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Carcinoma

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Spindle Cell Carcinoma:

33
Kidney, Skin, Breast, Lung, Tongue, Thyroid, Lymph node, Pancreas, Trachea, Liver, Uterus, Tonsil, Endothelial, Heart, Eye

Animal Models for Spindle Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5WT1, KRT18, MUC1, AMACR
2MP:00028737.9MUC1, ACTC1, SYP, WT1
3MP:00107687.6WT1, KRT18, SNAI2, ACTC1, AMACR
4MP:00053787.5AMACR, ACTC1, SNAI2, KRT18, WT1

Publications for Spindle Cell Carcinoma

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52PubMed
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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney: a case report. (23374174)
2013
2
Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature. (24330589)
2013
3
Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. (21684183)
2012
4
Spindle cell carcinoma of the lung. (21308442)
2011
5
A case of esophageal spindle cell carcinoma. (21957183)
2011
6
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (21415004)
2011
7
N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. (21070371)
2011
8
Post irradiation spindle cell carcinoma of tonsillar pillar. (22203850)
2011
9
Spindle cell carcinoma of the nasal cavity. (20838841)
2011
10
Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck--hallmark of epithelial-mesenchymal transition. (21237487)
2011
11
Clinicopathological and immunohistochemical features of oral spindle cell carcinoma. (20002980)
2010
12
Mucinous tubular and spindle cell carcinoma of the kidney. (20022029)
2010
13
Fine needle aspiration cytology of spindle cell carcinoma of the tongue: a case report with emphasis on the diagnostic difficulties. (18691220)
2010
14
Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. (20730609)
2010
15
Fine needle aspiration biopsy of renal mucinous tubular and spindle cell carcinoma: report of two cases. (19626627)
2010
16
Spindle cell lesions--neoplastic or non-neoplastic?: spindle cell carcinoma and other atypical spindle cell lesions of the head and neck. (20614332)
2008
17
Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. (18712413)
2008
18
Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. (17721310)
2007
19
Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. (17098672)
2006
20
A 15-year-old girl with a spindle cell carcinoma of the parotid gland. A diagnostic challenge solved by immunohistochemistry and cytogenetic analysis. (16308263)
2006
21
Renal mucinous and tubular spindle cell carcinoma: a clinicopathological study of 4 cases. (17396379)
2006
22
Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney. (16267782)
2006
23
Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. (17122511)
2006
24
Cutaneous spindle cell carcinoma following basal cell carcinoma. (15677971)
2005
25
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma. (14767509)
2004
26
Spindle cell carcinoma of the intrahepatic bile duct in a patient with primary sclerosing cholangitis. (14673729)
2003
27
Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. (12047767)
2002
28
So-called carcinosarcoma of the gallbladder; spindle cell carcinoma of the gallbladder: report of a case. (12061703)
2002
29
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
30
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. (11474284)
2001
31
Spindle cell carcinoma of the oral cavity. Report o f a case. (11507539)
2000
32
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
33
Spindle cell carcinoma of the larynx and hypopharynx. (9018257)
1997
34
Spindle cell carcinoma of the breast: a case report and an immunohistochemical study including p53 and Ki-67 expression. (9211529)
1997
35
Spindle cell carcinoma of the conjunctiva. (7536697)
1995
36
A combined small cell and spindle cell carcinoma of the lung. Report of a unique case with immunohistochemical and ultrastructural studies. (1335211)
1992
37
Lymph node metastasis in spindle cell carcinoma arising in odontogenic cyst. Report of a case. (2003016)
1991
38
Proliferating trichilemmal cyst with spindle cell carcinoma. (1700885)
1990
39
Spindle-cell carcinoma of the oral cavity and larynx. Immunohistochemical aspects. (2474578)
1989
40
Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. (2473024)
1989
41
Spindle cell carcinoma of the larynx. (2482058)
1989
42
Undifferentiated spindle cell carcinoma of the thyroid in a dog. (3962088)
1986
43
The controversial role of radiotherapy in spindle cell carcinoma (pseudosarcoma) of the head and neck. (3836441)
1985
44
Oral findings of a spindle-cell carcinoma of the maxillary alveolar ridge. (3928707)
1985
45
Metastatic spindle-cell carcinoma. Cytologic features and differential diagnosis. (3859145)
1985
46
Spindle cell carcinoma of the hamster trachea induced by N-methyl-N-nitrosourea. (6837722)
1983
47
Treatment of anaplastic giant and spindle cell carcinoma of the thyroid gland with combination Adriamycin and radiation therapy. A new approach. (6883279)
1983
48
Spindle cell carcinoma of the vulva. (7117117)
1982
49
Spindle-cell carcinoma of the laryngopharynx. (720254)
1978
50
Spindle cell carcinoma arising in chronic osteomyelitis. A case report and re-assessment of the literature. (753447)
1978

Variations for Spindle Cell Carcinoma

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Expression for genes affiliated with Spindle Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
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Pathways related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
9.1KRT18, ACTC1

Compounds for genes affiliated with Spindle Cell Carcinoma

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45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1dutp459.7KRT18, SYP
2deoxyribonucleic acid459.6WT1, AMACR
3lithium45 51 24 1112.6SYP, MUC1
4nash459.4KRT18, ACTC1
5gold459.4SYP, KRT18, MUC1
6ethanol45 51 24 1112.3MUC1, SYP, KRT18
7tetracycline45 1110.2WT1, KRT18
8s 100459.2ACTC1, MUC1, SYP
9reticulin459.2MUC1, ACTC1, SYP
10mucicarmine459.2SYP, MUC1, ACTC1
11biotin45 24 1111.2AMACR, MUC1, ACTC1
12butyrate459.1KRT18, WT1, MUC1
13thymidine45 2410.0WT1, MUC1, KRT18
14oligonucleotide459.0KRT18, AMACR, WT1
15cholesterol45 29 24 1111.9MUC1, SYP, AMACR
16lipid458.9SYP, MUC1, AMACR, KRT18
17cysteine458.9SYP, MUC1, AMACR, WT1
18ribonucleic acid458.9MUC1, ACTC1, WT1
19forskolin45 51 1110.8WT1, KRT18, SYP, MUC1
20nitric oxide45 24 1110.8WT1, SYP, MUC1, KRT18
21zinc45 249.7WT1, SNAI2, AMACR, KRT18
22formaldehyde45 249.6KRT18, SYP, MUC1, ACTC1
23glycogen45 249.6ACTC1, MUC1, KRT18, SYP
24b 723458.6WT1, MUC1, ACTC1, SYP
25glucose458.5AMACR, KRT18, MUC1, ACTC1
26serine458.5MUC1, SYP, KRT18, WT1
27matrigel458.5KRT18, SNAI2, MUC1, ACTC1
28steroid458.4KRT18, WT1, ACTC1, SYP
29hematoxylin458.3KRT18, MUC1, AMACR, SYP, ACTC1
30dexamethasone45 51 29 1111.3KRT18, ACTC1, MUC1, AMACR, SYP
31creatinine458.0WT1, KRT18, SYP, ACTC1, MUC1
32vegf458.0MUC1, KRT18, SYP, ACTC1, WT1
33paraffin457.7KRT18, AMACR, MUC1, ACTC1, SYP, WT1
34progesterone45 29 61 24 1111.7KRT18, SYP, ACTC1, MUC1, AMACR, WT1
35testosterone45 61 24 1110.7WT1, KRT18, SYP, ACTC1, MUC1, AMACR
36retinoic acid45 248.7AMACR, WT1, KRT18, SYP, ACTC1, MUC1
37estrogen457.2ACTC1, MUC1, KRT18, AMACR, SYP, SNAI2
38tyrosine457.1SYP, AMACR, MUC1, ACTC1, KRT18, WT1

GO Terms for genes affiliated with Spindle Cell Carcinoma

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16Gene Ontology
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Cellular components related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.5SNAI2, MUC1
2cytoplasmGO:0057376.9WT1, KRT18, SNAI2, ACTC1, MUC1, AMACR

Biological processes related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:0430668.5WT1, KRT18, ACTC1

Products for genes affiliated with Spindle Cell Carcinoma

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Sources for Spindle Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet