MCID: SPN032
MIFTS: 54

Spindle Cell Carcinoma malady

Cancer diseases category

Summaries for Spindle Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to squamous cell carcinoma and papillary carcinoma. An important gene associated with Spindle Cell Carcinoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cytoskeletal Signaling. The compounds glutamate and forskolin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and breast, and related mouse phenotypes are cardiovascular system and normal.

Wikipedia:63 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Aliases & Classifications for Spindle Cell Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell carcinoma 8
carcinoma, spindle-cell 60
carcinoma spindle cell 44
sarcomatoid carcinoma 8


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Disease Ontology8 DOID:4015
MeSH34 D002277
SNOMED-CT56 23109009, 65692009
NCIt39 C27004

Related Diseases for Spindle Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.8CHGA, MUC1, SNAI2, AMACR, SYP, S100A1
2papillary carcinoma30.6KRT18, MUC1, CHGA, S100A1, SYP, KRT7
3neuroendocrine carcinoma30.6MUC1, S100B, KRT7, KRT1, KRT18, ENO2
4spindle cell sarcoma30.4ACTC1, KRT7, DES, MUC1, S100B
5sarcoma30.4MUC1, S100A1, ACTC1, CD34, S100B, ENO2
6bladder carcinoma30.3KRT18
7large cell carcinoma30.3SYP, KRT7, ENO2, CHGA
8transitional cell carcinoma30.3KRT18, ENO2, KRT7
9giant cell tumor30.2S100B, DES, ACTC1, MUC1
10fibrous histiocytoma30.2ACTC1, DES, S100B, CD34
11malignant mesothelioma30.2MUC1, SNAI2, S100A1, DES, WT1, KRT7
12hepatitis30.1AMACR
13neuroblastoma30.1ENO2, SYP
14leukemia30.1BMP4, WT1, CD34
15renal clear cell carcinoma30.1AMACR, CDH16, S100A1, MUC1, KRT7
16basal cell carcinoma30.1CD34, ACTC1, KRT7
17adenoid cystic carcinoma30.1KRT7, ACTC1, S100B, S100A1, MUC1
18granular cell tumor30.1S100B, S100A1, SYP, ENO2, DES
19lung small cell carcinoma30.1ENO2, SYP, MUC1, KRT7, AMACR, CHGA
20adenoma30.1MUC1, S100A1, KRT18, KRT7, SYP, ENO2
21melanoma30.1S100B, KRT18, S100A1, SNAI2, BMP4, AMACR
22adenocarcinoma30.1MUC1, KRT18, KRT1, CD34, KRT7, SYP
23lung adenocarcinoma30.0MUC1, KRT18, KRT7, AMACR
24renal cell carcinoma10.7
25mucinous tubular and spindle renal cell carcinoma10.7
26breast metaplastic carcinoma10.5
27papillary renal cell carcinoma10.4
28pleomorphic carcinoma10.4
29thyroiditis10.4
30bile duct carcinoma10.4
31rectum sarcomatoid carcinoma10.3
32sarcomatoid mesothelioma10.3
33thymus sarcomatoid carcinoma10.3
34sarcomatoid squamous cell skin carcinoma10.3
35mucinous tubular and spindle cell carcinoma10.3
36blastoma10.2
37conjunctiva squamous cell carcinoma10.2
38lung combined large cell neuroendocrine carcinoma10.2
39small cell carcinoma10.2
40spindle cell variant squamous cell breast carcinoma10.2
41esophagitis10.2
42laryngeal carcinoma10.2
43laryngitis10.2
44lung large cell carcinoma10.2
45pulmonary blastoma10.2
46bone carcinoma10.2
47bladder diverticulum10.2
48bladder squamous cell carcinoma10.2
49histiocytoma10.2
50prostatitis10.2

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Clinical Features for Spindle Cell Carcinoma

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Drugs & Therapeutics for Spindle Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Carcinoma

Search NIH Clinical Center for Spindle Cell Carcinoma

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Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Carcinoma:

32
Skin, Kidney, Breast, Lung, Thyroid, Tongue, Lymph node, Pancreas, Trachea, Liver, Uterus, Tonsil, Endothelial, Heart, Eye

Animal Models for Spindle Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.4WT1, BMP4, SNAI1, DES, CHGA, ACTC1
2MP:00028739.1S100B, S100A1, WT1, BMP4, SNAI1, SYP
3MP:00107688.8TWIST1, AMACR, WT1, BMP4, SNAI1, SNAI2

Publications for Spindle Cell Carcinoma

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50PubMed
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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro. (23962337)
2013
2
Urinary bladder urothelial carcinoma with expression of KIT and PDGFRA and showing diverse differentiations into plasmacytoid, clear cell, acantholytic, nested, and spindle variants, and into adenocarcinoma, signet-ring cell carcinoma, small cell carcinoma, large cell carcinoma, and pleomorphic carcinoma. (23696935)
2013
3
Metaplastic carcinoma of the breast with transformation from adenosquamous carcinoma to osteosarcomatoid and spindle cell morphology. (24137400)
2013
4
Cutaneous basal cell carcinoma with dual differentiation into squamous cell carcinoma and spindle cell squamous cell carcinoma: a case report with immunohistochemical studies. (23227812)
2013
5
Spindle cell ameloblastic carcinoma in a labrador retriever dog. (23229541)
2013
6
Low-grade fibromatosis-like spindle cell metaplastic carcinoma of the breast: a case report and literature review. (22444721)
2012
7
Spindle cell typical carcinoid tumor (well-differentiated neuroendocrine carcinoma) diagnosed by electromagnetic navigation bronchoscopy with cytologic rapid on-site evaluation. (21987437)
2012
8
Primary spindle cell carcinoma of the frontal sinus. (22959877)
2012
9
Spindle cell variant of ameloblastic carcinoma arising from an unicystic amelobastoma: Report of a rare case. (23087740)
2012
10
Study of D2-40 immunoexpression of the spindle cell areas of a metaplastic basal cell carcinoma (sarcomatoid basal cell carcinoma). (21602664)
2012
11
Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man. (21970492)
2011
12
Spindle cell carcinoma of the breast: MR findings correlated with histopathology. (21720116)
2011
13
Clinicopathological and immunohistochemical features of oral spindle cell carcinoma. (20002980)
2010
14
Mucinous tubular and spindle cell carcinoma of the kidney. (20022029)
2010
15
Fine needle aspiration biopsy of renal mucinous tubular and spindle cell carcinoma: report of two cases. (19626627)
2010
16
Magnetic resonance imaging characterization of a mucinous tubular and spindle cell carcinoma of the kidney detected incidentally during an ectopic pregnancy. (19962725)
2010
17
Vascular endothelial growth factors and their receptors in the novel human cell line, HN-Eso-1, established from esophageal spindle cell carcinoma. (20847522)
2010
18
Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid differentiation. (18784804)
2008
19
Polypoid spindle cell carcinoma of the esophagus. (17249460)
2007
20
Spindle cell carcinoma arising in the pharynx, with granulocytosis and high serum granulocyte colony stimulating factor titre. (17147842)
2007
21
HER2 and EGFR expression in cutaneous spindle squamous cell carcinoma. (18032952)
2007
22
Renal mucinous and tubular spindle cell carcinoma: a clinicopathological study of 4 cases. (17396379)
2006
23
Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. (17122511)
2006
24
Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature. (16231179)
2005
25
Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects. (15578440)
2005
26
Spindle cell transformation of papillary carcinoma: an aggressive entity distinct from anaplastic thyroid carcinoma. (14692805)
2004
27
Spindle cell carcinoma of the breast: a case series of a rare histological subtype. (12943626)
2003
28
Epithelioid sarcoma: an immunohistochemical analysis evaluating the utility of cytokeratin 5/6 in distinguishing superficial epithelioid sarcoma from spindled squamous cell carcinoma. (12641789)
2003
29
Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas. (12931544)
2003
30
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. (11474284)
2001
31
Spindle cell carcinoma of the tongue in a long-term survivor of childhood acute lymphoblastic leukemia. (9021817)
1997
32
Spindle cell carcinoma of the parotid gland. (7561485)
1995
33
Basaloid squamous cell carcinoma of the head and neck with a spindle cell component. An unusual histologic variant. (7848067)
1995
34
Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. (8227214)
1993
35
Spindle cell carcinoma of the breast. (1694516)
1990
36
Spindle cell carcinomas. Immunohistochemical analysis of 15 cases]. (2130227)
1990
37
Intermediate filament proteins in spindle cell carcinoma of the larynx and tongue. (2459899)
1988
38
Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumors and comparison with seven monophasic spindle-cell tumors. (2430474)
1986
39
Spindle cell carcinoma of the breast: case report and review. (3736058)
1986
40
Spindle cell carcinoma (pseudosarcoma) of the anus: a light, electron microscopic and immunocytochemical study of a case. (2415439)
1985
41
Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions. A clinicopathologic and immunohistochemical study of 21 cases. (2578080)
1985
42
Spindle cell carcinoma of the hamster trachea induced by N-methyl-N-nitrosourea. (6837722)
1983
43
Treatment of anaplastic giant and spindle cell carcinoma of the thyroid gland with combination Adriamycin and radiation therapy. A new approach. (6883279)
1983
44
Spindle cell carcinoma of the conjunctiva. (7425908)
1980
45
Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases. (6935609)
1980
46
Juvenile spindle cell carcinoma. (503519)
1979
47
Spindle cell carcinoma: ultrastructural evidence of squamous origin and collagen production by the tumor cells. (1260715)
1976
48
SQUAMOUS CELL CARCINOMA OF THE LARYNX WITH SARCOMA-LIKE STROMA. A CLINICOPATHOLOGIC ASSESSMENT OF SPINDLE CELL CARCINOMA AND "PSEUDOSARCOMA". (14323485)
1965
49
SPINDLE-CELL CARCINOMA OF THE FLOOR OF THE MOUTH; REPORT OF A CASE. (14342934)
1965
50
Polypoid and junctional squamous cell carcinoma of the tongue and larynx with spindle cell carcinoma ("pseudosarcoma"). (13977205)
1963

Genetic Variations for Spindle Cell Carcinoma

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Expression for genes affiliated with Spindle Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KRT1, KRT18, KRT7
29.9ACTC1, KRT7, KRT18, DES
39.9TWIST1, SNAI2, SNAI1, BMP4
4
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9.5BMP4, SNAI1, SNAI2, DES, MUC1, CDH16

Compounds for genes affiliated with Spindle Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1glutamate4410.5AMACR
2forskolin44 49 1112.5ENO2, WT1, KRT18
3orcein4410.4ACTC1, DES, S100B
4smcc4410.4SYP, CHGA, ENO2
5dexamethasone44 49 28 1113.3KRT18, ENO2, AMACR, S100B
6creatinine4410.3CHGA, WT1, ACTC1, SYP, KRT18
7toluidine4410.3DES, S100A1, ENO2
8l-amino acid4410.3SYP, CHGA, S100B, ENO2
9etoposide44 49 59 1113.2CHGA, WT1, S100B
10glycogen44 2411.2SYP, KRT18, KRT7, ACTC1, CHGA
11glucose4410.2KRT18, ACTC1, KRT7, AMACR, MUC1
12gold4410.2MUC1, SYP, DES, CHGA, KRT18
13acetylcholine44 49 28 11 2414.2ENO2, SYP, S100A1, CHGA
14dbc-amp4410.2ENO2, S100B, SYP, BMP4
15dopamine44 28 11 2413.1CHGA, BMP4, KRT18, ENO2
16biotin44 11 2412.1S100A1, AMACR, DES, MUC1, KRT1, ACTC1
17streptavidin4410.1AMACR, KRT7, DES
18serine4410.1KRT1, SYP, DES, WT1, S100B
19acth4410.1SYP, S100B, ENO2, MUC1, CHGA
20catecholamine4410.0S100B, CHGA, ENO2, SYP
21steroid4410.0KRT1, BMP4, WT1, ACTC1, KRT18, SYP
22ribonucleic acid4410.0MUC1, ENO2, ACTC1, CHGA, WT1, BMP4
23mucicarmine4410.0S100A1, DES, ACTC1, KRT7, MUC1, SYP
2412-o-tetradecanoylphorbol 13-acetate4410.0DES, MUC1, KRT1, CD34, WT1, CHGA
25s 1004410.0ENO2, S100B, DES, SYP, CHGA, MUC1
26reticulin449.9DES, ACTC1, KRT7, CD34, MUC1, SYP
27matrigel449.9KRT7, BMP4, MUC1, KRT18, CHGA, ACTC1
28silver449.9CD34, ENO2, CHGA, SYP, DES, S100A1
29bromodeoxyuridine449.9ENO2, KRT1, CHGA, DES, BMP4, S100B
30ethanol44 49 11 2412.9S100B, KRT18, MUC1, SYP, DES
31threonine449.8KRT18, KRT1, MUC1, S100B, WT1, BMP4
32b 723449.7S100B, S100A1, WT1, DES, SYP, CHGA
33thymidine44 2410.7MUC1, S100B, WT1, BMP4, DES, CD34
34iron44 2410.7S100B, BMP4, S100A1, DES, KRT18, KRT7
35adenylate449.7ENO2, CHGA, DES, BMP4, S100B, AMACR
36formaldehyde44 2410.7KRT7, SYP, DES, S100B, ENO2, ACTC1
37cysteine449.7S100B, AMACR, S100A1, BMP4, WT1, DES
38norepinephrine44 11 2411.7S100B, SYP, CHGA, ENO2, DES
39lipid449.6MUC1, KRT7, ENO2, KRT18, KRT1, AMACR
40nitric oxide44 11 2411.5ENO2, S100A1, S100B, CHGA, WT1, BMP4
41zinc44 2410.4SNAI2, S100B, AMACR, SNAI1, BMP4, WT1
42testosterone44 59 11 2412.3ACTC1, AMACR, S100B, WT1, DES, CHGA
43vegf449.2ACTC1, KRT7, KRT18, CD34, MUC1, ENO2
44oxygen44 2410.2MUC1, ENO2, S100B, DES, CHGA, ACTC1
45calcium44 49 11 2412.2S100A1, S100B, AMACR, BMP4, ENO2, KRT1
46hematoxylin449.1DES, S100A1, S100B, AMACR, ENO2, ACTC1
47paraffin449.0AMACR, S100B, S100A1, WT1, DES, SYP
48progesterone44 59 28 11 2412.9S100A1, S100B, AMACR, WT1, CHGA, MUC1
49retinoic acid44 249.8ACTC1, ENO2, AMACR, S100B, KRT7, KRT18
50tyrosine448.6WT1, TWIST1, ENO2, ACTC1, KRT7, KRT18

GO Terms for genes affiliated with Spindle Cell Carcinoma

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16Gene Ontology
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Cellular components related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.1KRT7, KRT18, DES
2keratin filamentGO:0450959.8KRT1, KRT18, KRT7
3cytoplasmGO:0057378.8ACTC1, AMACR, S100B, WT1, SNAI1, SNAI2

Biological processes related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of vitamin D biosynthetic processGO:01095710.3SNAI2, SNAI1
2negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.3TWIST1, SNAI2, SNAI1
3cartilage morphogenesisGO:06053610.2SNAI2, SNAI1
4negative regulation of chondrocyte differentiationGO:03233110.2SNAI2, BMP4
5cranial suture morphogenesisGO:06036310.2BMP4, TWIST1
6osteoblast differentiationGO:00164910.1BMP4, SNAI1, SNAI2, TWIST1
7regulation of tight junction assemblyGO:200081010.1SNAI2, SNAI1
8negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageGO:19022309.9SNAI2, SNAI1
9negative regulation of transcription from RNA polymerase II promoterGO:0001229.8S100A1, WT1, BMP4, SNAI1, SNAI2, TWIST1

Molecular functions related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.2S100A1, S100B

Products for genes affiliated with Spindle Cell Carcinoma

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Sources for Spindle Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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