MCID: SPN032
MIFTS: 54

Spindle Cell Carcinoma malady

Cancer diseases category

Summaries for Spindle Cell Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to squamous cell carcinoma and papillary carcinoma. An important gene associated with Spindle Cell Carcinoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cytoskeletal Signaling. The compounds glutamate and forskolin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and breast, and related mouse phenotypes are cardiovascular system and normal.

Wikipedia:63 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Aliases & Classifications for Spindle Cell Carcinoma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell carcinoma 8
carcinoma, spindle-cell 60
carcinoma spindle cell 44
sarcomatoid carcinoma 8


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Disease Ontology8 DOID:4015
MeSH34 D002277
SNOMED-CT56 23109009, 65692009
NCIt39 C27004

Related Diseases for Spindle Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.8CHGA, MUC1, SNAI2, AMACR, SYP, S100A1
2papillary carcinoma30.6KRT18, MUC1, CHGA, S100A1, SYP, KRT7
3neuroendocrine carcinoma30.6MUC1, S100B, KRT7, KRT1, KRT18, ENO2
4spindle cell sarcoma30.4ACTC1, KRT7, DES, MUC1, S100B
5sarcoma30.4MUC1, S100A1, ACTC1, CD34, S100B, ENO2
6bladder carcinoma30.3KRT18
7large cell carcinoma30.3SYP, KRT7, ENO2, CHGA
8transitional cell carcinoma30.3KRT18, ENO2, KRT7
9giant cell tumor30.2S100B, DES, ACTC1, MUC1
10fibrous histiocytoma30.2ACTC1, DES, S100B, CD34
11malignant mesothelioma30.2MUC1, SNAI2, S100A1, DES, WT1, KRT7
12hepatitis30.1AMACR
13neuroblastoma30.1ENO2, SYP
14leukemia30.1BMP4, WT1, CD34
15renal clear cell carcinoma30.1AMACR, CDH16, S100A1, MUC1, KRT7
16basal cell carcinoma30.1CD34, ACTC1, KRT7
17adenoid cystic carcinoma30.1KRT7, ACTC1, S100B, S100A1, MUC1
18granular cell tumor30.1S100B, S100A1, SYP, ENO2, DES
19lung small cell carcinoma30.1ENO2, SYP, MUC1, KRT7, AMACR, CHGA
20adenoma30.1MUC1, S100A1, KRT18, KRT7, SYP, ENO2
21melanoma30.1S100B, KRT18, S100A1, SNAI2, BMP4, AMACR
22adenocarcinoma30.1MUC1, KRT18, KRT1, CD34, KRT7, SYP
23lung adenocarcinoma30.0MUC1, KRT18, KRT7, AMACR
24renal cell carcinoma10.7
25mucinous tubular and spindle renal cell carcinoma10.7
26breast metaplastic carcinoma10.5
27papillary renal cell carcinoma10.4
28pleomorphic carcinoma10.4
29thyroiditis10.4
30bile duct carcinoma10.4
31rectum sarcomatoid carcinoma10.3
32sarcomatoid mesothelioma10.3
33thymus sarcomatoid carcinoma10.3
34sarcomatoid squamous cell skin carcinoma10.3
35mucinous tubular and spindle cell carcinoma10.3
36blastoma10.2
37conjunctiva squamous cell carcinoma10.2
38lung combined large cell neuroendocrine carcinoma10.2
39small cell carcinoma10.2
40spindle cell variant squamous cell breast carcinoma10.2
41esophagitis10.2
42laryngeal carcinoma10.2
43laryngitis10.2
44lung large cell carcinoma10.2
45pulmonary blastoma10.2
46bone carcinoma10.2
47bladder diverticulum10.2
48bladder squamous cell carcinoma10.2
49histiocytoma10.2
50prostatitis10.2

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Clinical Features for Spindle Cell Carcinoma

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Drugs & Therapeutics for Spindle Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Carcinoma

Search NIH Clinical Center for Spindle Cell Carcinoma

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Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Carcinoma:

32
Skin, Kidney, Breast, Lung, Thyroid, Tongue, Lymph node, Pancreas, Trachea, Liver, Uterus, Tonsil, Endothelial, Heart, Eye

Animal Models for Spindle Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.4WT1, BMP4, SNAI1, DES, CHGA, ACTC1
2MP:00028739.1S100B, S100A1, WT1, BMP4, SNAI1, SYP
3MP:00107688.8TWIST1, AMACR, WT1, BMP4, SNAI1, SNAI2

Publications for Spindle Cell Carcinoma

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50PubMed
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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 277)
idTitleAuthorsYear
1
Spindle cell carcinoma of the nasal cavity. (23772295)
2013
2
Spindle-cell carcinoma of the hypopharynx presenting with a pedunculated appearance: CT and MR features. (23229865)
2013
3
Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. (21684183)
2012
4
Mucin poor mucinous tubular and spindle cell carcinoma of the kidney, with nonclassic morphologic variant of spindle cell predominance and psammomatous calcification. (21310639)
2012
5
Post irradiation spindle cell carcinoma of tonsillar pillar. (22203850)
2011
6
Spindle cell carcinoma of the nasal cavity. (20838841)
2011
7
Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck--hallmark of epithelial-mesenchymal transition. (21237487)
2011
8
High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study. (21106420)
2011
9
Metastatic Squamous Spindle Cell Carcinoma of the conjunctiva. (23960894)
2010
10
A case of oral multiple primary cancer including Spindle Cell Carcinoma. (22190791)
2010
11
Anaplastic spindle cell carcinoma, arising in a background of an ovarian mucinous cystic tumor: a case report with clinical follow up, review of the literature. (21151395)
2010
12
Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to sunitinib. (20679595)
2010
13
Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma. (19476522)
2009
14
Ameloblastic carcinoma (spindle cell variant). (19291545)
2009
15
Transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma of the head and neck. (19381684)
2009
16
Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. (18712413)
2008
17
Diagnostic utility of P63 and CD10 in distinguishing cutaneous spindle cell/sarcomatoid squamous cell carcinomas and atypical fibroxanthomas. (18787630)
2008
18
Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3: a histological, immunohistochemical, ultrastructural and FISH study. (18830937)
2008
19
An unusual renal neoplasm: mucinous tubular and spindle cell carcinoma]. (18501307)
2008
20
Renal mucinous tubular and spindle cell carcinoma. (19066686)
2008
21
Weakened spindle checkpoint with reduced BubR1 expression in paclitaxel-resistant ovarian carcinoma cell line SKOV3-TR30. (17234259)
2007
22
A 15-year-old girl with a spindle cell carcinoma of the parotid gland. A diagnostic challenge solved by immunohistochemistry and cytogenetic analysis. (16308263)
2006
23
Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney. (16267782)
2006
24
Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. (16554730)
2006
25
Mucinous tubular and spindle-cell carcinoma of the kidney]. (16986488)
2006
26
Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. (16330937)
2006
27
Curative ablation of a polypoid oesophageal spindle cell carcinoma with argon beam diathermy. (16003139)
2005
28
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma. (14767509)
2004
29
Spindle cell carcinoma of the larynx. (15121229)
2004
30
Spindle-cell ameloblastic carcinoma: A case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses. (12469140)
2003
31
Condyloma acuminatum-like lesion of the urinary bladder progressing to invasive spindle cell carcinoma. (14675927)
2003
32
Production of spindle cell carcinoma by transduction of H-Ras 61L into immortalized human mammary epithelial cells. (14580689)
2003
33
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
34
Spindle cell carcinoma of the lung: a clinicopathologic presentation of three cases. (9556949)
1998
35
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. (9350106)
1997
36
Spindle cell endocrine carcinoma of the mammary gland. (8797935)
1996
37
Alteration of the p53 gene of lung carcinomas with sarcomatous transformation (spindle cell carcinoma): analysis of four cases. (10846548)
1996
38
Pathology in focus. Spindle-cell carcinoma of the nasal septum. (8730373)
1996
39
Encapsulated follicular thyroid carcinoma exhibiting glandular and spindle cell components. A case report. (8685044)
1996
40
Spindle cell carcinoma of the conjunctiva. (7536697)
1995
41
Head and neck spindle cell carcinoma: an evaluation of current management. (1281758)
1992
42
Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. (1718079)
1991
43
Spindle cell carcinoma of the renal pelvis. Immunohistochemical and ultrastructural study of a case demonstrating coexpression of keratin and vimentin intermediate filaments. (2468323)
1989
44
Spindle cell carcinoma of cornea and conjunctiva with pseudosarcomatous metaplasia. Light microscopic, electron microscopic and immunohistochemical findings in 2 patients. (2509163)
1989
45
Spindle cell carcinoma of the uterus. (3307294)
1987
46
Spindle cell carcinoma of the larynx. (6464720)
1984
47
Spindle-cell carcinoma of the oral cavity. (6959736)
1982
48
Spindle cell carcinoma of the nose and paranasal sinuses. (401264)
1978
49
Spindle cell carcinoma (pseudosarcoma) of the larynx. (1119994)
1975
50
Spindle-cell carcinoma of the tongue. Report of a case. (5253548)
1969

Genetic Variations for Spindle Cell Carcinoma

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Expression for genes affiliated with Spindle Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KRT1, KRT18, KRT7
29.9ACTC1, KRT7, KRT18, DES
39.9TWIST1, SNAI2, SNAI1, BMP4
4
Hide members
9.5BMP4, SNAI1, SNAI2, DES, MUC1, CDH16

Compounds for genes affiliated with Spindle Cell Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1glutamate4410.5AMACR
2forskolin44 49 1112.5ENO2, KRT18, WT1
3orcein4410.4S100B, DES, ACTC1
4smcc4410.4SYP, CHGA, ENO2
5dexamethasone44 49 28 1113.3AMACR, S100B, KRT18, ENO2
6creatinine4410.3WT1, SYP, CHGA, KRT18, ACTC1
7toluidine4410.3S100A1, DES, ENO2
8l-amino acid4410.3S100B, SYP, CHGA, ENO2
9etoposide44 49 59 1113.2S100B, WT1, CHGA
10glycogen44 2411.2SYP, CHGA, KRT18, KRT7, ACTC1
11glucose4410.2AMACR, MUC1, KRT18, KRT7, ACTC1
12gold4410.2DES, SYP, CHGA, MUC1, KRT18
13acetylcholine44 49 28 11 2414.2S100A1, SYP, CHGA, ENO2
14dbc-amp4410.2ENO2, SYP, BMP4, S100B
15dopamine44 28 11 2413.1BMP4, CHGA, KRT18, ENO2
16biotin44 11 2412.1AMACR, S100A1, DES, MUC1, KRT1, ACTC1
17streptavidin4410.1KRT7, DES, AMACR
18serine4410.1S100B, WT1, DES, SYP, KRT1
19acth4410.1S100B, SYP, CHGA, MUC1, ENO2
20catecholamine4410.0ENO2, CHGA, SYP, S100B
21steroid4410.0WT1, BMP4, DES, SYP, KRT1, KRT18
22ribonucleic acid4410.0ENO2, ACTC1, MUC1, CHGA, BMP4, WT1
23mucicarmine4410.0MUC1, SYP, DES, S100A1, S100B, KRT7
24s 1004410.0ENO2, ACTC1, MUC1, CHGA, SYP, DES
2512-o-tetradecanoylphorbol 13-acetate4410.0KRT1, CD34, MUC1, CHGA, DES, WT1
26reticulin449.9ACTC1, KRT7, CD34, MUC1, SYP, DES
27matrigel449.9BMP4, SNAI2, CHGA, MUC1, KRT18, KRT7
28silver449.9S100A1, DES, SYP, CHGA, CD34, ENO2
29bromodeoxyuridine449.9S100B, BMP4, DES, CHGA, KRT1, KRT18
30ethanol44 49 11 2412.9S100B, DES, SYP, MUC1, KRT18
31threonine449.8S100B, WT1, BMP4, DES, MUC1, KRT1
32b 723449.7ACTC1, KRT7, MUC1, CHGA, SYP, DES
33thymidine44 2410.7S100B, WT1, BMP4, DES, MUC1, CD34
34iron44 2410.7S100B, S100A1, BMP4, DES, KRT18, KRT7
35adenylate449.7AMACR, S100B, BMP4, DES, CHGA, ENO2
36formaldehyde44 2410.7S100B, DES, SYP, CHGA, MUC1, KRT18
37cysteine449.7AMACR, S100B, S100A1, WT1, BMP4, DES
38norepinephrine44 11 2411.7S100B, DES, SYP, CHGA, ENO2
39lipid449.6AMACR, S100B, SYP, CHGA, MUC1, KRT1
40nitric oxide44 11 2411.5S100B, S100A1, WT1, BMP4, DES, SYP
41zinc44 2410.4AMACR, S100B, S100A1, WT1, BMP4, SNAI1
42testosterone44 59 11 2412.3SYP, DES, WT1, S100B, AMACR, CHGA
43vegf449.2SYP, DES, BMP4, WT1, S100B, CHGA
44oxygen44 2410.2S100B, DES, CHGA, MUC1, KRT18, ACTC1
45calcium44 49 11 2412.2DES, BMP4, S100A1, S100B, AMACR, SYP
46hematoxylin449.1CD34, MUC1, CHGA, SYP, DES, S100A1
47paraffin449.0CD34, MUC1, CHGA, SYP, DES, WT1
48retinoic acid44 249.8ENO2, ACTC1, KRT7, KRT18, KRT1, CD34
49progesterone44 59 28 11 2412.8SYP, DES, BMP4, WT1, S100A1, S100B
50tyrosine448.6TWIST1, S100A1, S100B, AMACR, WT1, BMP4

GO Terms for genes affiliated with Spindle Cell Carcinoma

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16Gene Ontology
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Cellular components related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.1KRT7, KRT18, DES
2keratin filamentGO:0450959.8KRT1, KRT18, KRT7
3cytoplasmGO:0057378.8ACTC1, AMACR, S100B, WT1, SNAI1, SNAI2

Biological processes related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of vitamin D biosynthetic processGO:01095710.3SNAI2, SNAI1
2negative regulation of DNA damage response, signal transduction by p53 class mediatorGO:04351810.3TWIST1, SNAI2, SNAI1
3cartilage morphogenesisGO:06053610.2SNAI2, SNAI1
4negative regulation of chondrocyte differentiationGO:03233110.2SNAI2, BMP4
5cranial suture morphogenesisGO:06036310.2BMP4, TWIST1
6osteoblast differentiationGO:00164910.1BMP4, SNAI1, SNAI2, TWIST1
7regulation of tight junction assemblyGO:200081010.1SNAI2, SNAI1
8negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageGO:19022309.9SNAI2, SNAI1
9negative regulation of transcription from RNA polymerase II promoterGO:0001229.8S100A1, WT1, BMP4, SNAI1, SNAI2, TWIST1

Molecular functions related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.2S100A1, S100B

Products for genes affiliated with Spindle Cell Carcinoma

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Sources for Spindle Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet