MCID: SPN032
MIFTS: 50

Spindle Cell Carcinoma malady

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Summaries for Spindle Cell Carcinoma

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Disease Ontology:8 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to neuroendocrine carcinoma and giant cell tumor. An important gene associated with Spindle Cell Carcinoma is AMACR (alpha-methylacyl-CoA racemase), and among its related pathways is Development Slit Robo signaling. The compounds dutp and deoxyribonucleic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and breast, and related mouse phenotypes are liver/biliary system and normal.

Wikipedia:65 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Aliases & Classifications for Spindle Cell Carcinoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT
See all sources

Spindle Cell Carcinoma, Aliases & Descriptions:

Name: Spindle Cell Carcinoma 8
Carcinoma, Spindle-Cell 62
 
Carcinoma Spindle Cell 44
Sarcomatoid Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4015
NCIt39 C27004
SNOMED-CT57 65692009, 23109009
MeSH34 D002277

Related Diseases for Spindle Cell Carcinoma

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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma30.5KRT18, SYP, MUC1
2giant cell tumor30.4MUC1, ACTC1
3malignant pleural mesothelioma30.3WT1, MUC1
4sarcoma30.3WT1, ACTC1, MUC1
5lung adenocarcinoma30.2KRT18, MUC1, AMACR
6bladder carcinoma30.1ACTC1, KRT18
7malignant mesothelioma29.9WT1, ACTC1, MUC1
8melanoma29.7AMACR, ACTC1, SNAI2, KRT18
9rhabdoid tumor29.6WT1, SYP, ACTC1, MUC1
10adenoma29.5AMACR, MUC1, ACTC1, SYP, KRT18
11adenocarcinoma29.1AMACR, MUC1, ACTC1, SYP, KRT18, WT1
12mucinous tubular and spindle cell carcinoma11.0
13nephrogenic adenoma10.5AMACR
14renal cell carcinoma10.5
15thyroiditis10.5
16ganglioglioma10.5SYP
17papillary renal cell carcinoma10.4
18sarcomatoid squamous cell skin carcinoma10.4
19fibromatosis10.4
20kidney cancer10.4AMACR
21rectum sarcomatoid carcinoma10.4
22metanephric adenoma10.4WT1
23adenomatoid tumor10.4WT1
24thymus sarcomatoid carcinoma10.3
25prostatitis10.3
26adenosarcoma10.3ACTC1
27choroid plexus papilloma10.3MUC1, SYP
28sertoli cell tumor10.3MUC1, SYP
29blastoma10.3
30spindle cell variant squamous cell breast carcinoma10.3
31large cell neuroendocrine carcinoma10.3
32esophagitis10.3
33laryngitis10.3
34pulmonary blastoma10.3
35merkel cell carcinoma10.3SYP, MUC1
36hemangioblastoma10.3MUC1, SYP
37primary hyperoxaluria10.2WT1
38renal clear cell carcinoma10.2AMACR, MUC1
39hemangioma10.2ACTC1
40ependymoma10.2MUC1, SYP
41sarcomatoid mesothelioma10.2
42fibrous histiocytoma10.2
43bladder diverticulum10.2
44histiocytoma10.2
45chordoma10.2MUC1, KRT18
46desmoplastic small round cell tumor10.2MUC1, WT1
47sertoli-leydig cell tumor10.2WT1, MUC1
48sex cord-gonadal stromal tumor10.2MUC1, WT1
49pancreatic cancer10.2SYP, MUC1
50endometrial carcinoma10.1WT1, MUC1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Symptoms for Spindle Cell Carcinoma

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Drugs & Therapeutics for Spindle Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Carcinoma

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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MalaCards organs/tissues related to Spindle Cell Carcinoma:

32
Kidney, Skin, Breast, Lung, Tongue, Thyroid, Pancreas, Lymph node, Liver, Trachea, Eye, Heart, Uterus, Tonsil, Endothelial

Animal Models for Spindle Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5WT1, KRT18, MUC1, AMACR
2MP:00028737.9MUC1, ACTC1, SYP, WT1
3MP:00107687.6WT1, KRT18, SNAI2, ACTC1, AMACR
4MP:00053787.5AMACR, ACTC1, SNAI2, KRT18, WT1

Publications for Spindle Cell Carcinoma

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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. (25013496)
2014
2
Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. (24634155)
2014
3
Management of spindle cell carcinoma of the maxillary sinus: a case report and literature review. (25350698)
2014
4
Spindle cell carcinoma of the breast as complex cystic lesion: a case report. (25009755)
2014
5
Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma. (25114719)
2014
6
Clear cell changes in mucinous tubular and spindle cell carcinoma: cytoplasmic pallor/clearing within tubules, vacuoles or hybrid conventional clear cell carcinoma of kidney? (25120820)
2014
7
The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney: a case report. (23374174)
2013
8
Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature. (24330589)
2013
9
Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor. (21684183)
2012
10
Spindle cell carcinoma of the lung. (21308442)
2011
11
A case of esophageal spindle cell carcinoma. (21957183)
2011
12
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (21415004)
2011
13
N-cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. (21070371)
2011
14
Post irradiation spindle cell carcinoma of tonsillar pillar. (22203850)
2011
15
Spindle cell carcinoma of the nasal cavity. (20838841)
2011
16
Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck--hallmark of epithelial-mesenchymal transition. (21237487)
2011
17
Clinicopathological and immunohistochemical features of oral spindle cell carcinoma. (20002980)
2010
18
Mucinous tubular and spindle cell carcinoma of the kidney. (20022029)
2010
19
Fine needle aspiration cytology of spindle cell carcinoma of the tongue: a case report with emphasis on the diagnostic difficulties. (18691220)
2010
20
Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. (20730609)
2010
21
Spindle cell lesions--neoplastic or non-neoplastic?: spindle cell carcinoma and other atypical spindle cell lesions of the head and neck. (20614332)
2008
22
Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck. (18712413)
2008
23
Invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. (17721310)
2007
24
Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. (17098672)
2006
25
A 15-year-old girl with a spindle cell carcinoma of the parotid gland. A diagnostic challenge solved by immunohistochemistry and cytogenetic analysis. (16308263)
2006
26
Renal mucinous and tubular spindle cell carcinoma: a clinicopathological study of 4 cases. (17396379)
2006
27
Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney. (16267782)
2006
28
Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. (17122511)
2006
29
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma. (14767509)
2004
30
Spindle cell carcinoma of the intrahepatic bile duct in a patient with primary sclerosing cholangitis. (14673729)
2003
31
Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. (12047767)
2002
32
So-called carcinosarcoma of the gallbladder; spindle cell carcinoma of the gallbladder: report of a case. (12061703)
2002
33
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
34
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. (11474284)
2001
35
Spindle cell carcinoma of the oral cavity. Report o f a case. (11507539)
2000
36
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
37
Spindle cell carcinoma of the larynx and hypopharynx. (9018257)
1997
38
Spindle cell carcinoma of the breast: a case report and an immunohistochemical study including p53 and Ki-67 expression. (9211529)
1997
39
Spindle cell carcinoma of the conjunctiva. (7536697)
1995
40
A combined small cell and spindle cell carcinoma of the lung. Report of a unique case with immunohistochemical and ultrastructural studies. (1335211)
1992
41
Spindle-cell carcinoma of the oral cavity and larynx. Immunohistochemical aspects. (2474578)
1989
42
Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. (2473024)
1989
43
Spindle cell carcinoma of the larynx. (2482058)
1989
44
Undifferentiated spindle cell carcinoma of the thyroid in a dog. (3962088)
1986
45
The controversial role of radiotherapy in spindle cell carcinoma (pseudosarcoma) of the head and neck. (3836441)
1985
46
Oral findings of a spindle-cell carcinoma of the maxillary alveolar ridge. (3928707)
1985
47
Metastatic spindle-cell carcinoma. Cytologic features and differential diagnosis. (3859145)
1985
48
Spindle cell carcinoma of the hamster trachea induced by N-methyl-N-nitrosourea. (6837722)
1983
49
Spindle cell carcinoma of the vulva. (7117117)
1982
50
Spindle-cell carcinoma of the laryngopharynx. (720254)
1978

Variations for Spindle Cell Carcinoma

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Expression for genes affiliated with Spindle Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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Pathways related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.1KRT18, ACTC1

Compounds for genes affiliated with Spindle Cell Carcinoma

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Compounds related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1dutp449.7KRT18, SYP
2deoxyribonucleic acid449.6AMACR, WT1
3lithium44 50 24 1112.6MUC1, SYP
4nash449.4KRT18, ACTC1
5gold449.4MUC1, SYP, KRT18
6ethanol44 50 24 1112.3MUC1, SYP, KRT18
7tetracycline44 1110.2WT1, KRT18
8s 100449.2SYP, ACTC1, MUC1
9reticulin449.2SYP, ACTC1, MUC1
10mucicarmine449.2MUC1, ACTC1, SYP
11biotin44 24 1111.2ACTC1, MUC1, AMACR
12butyrate449.1MUC1, KRT18, WT1
13thymidine44 2410.0WT1, KRT18, MUC1
14oligonucleotide449.0WT1, KRT18, AMACR
15cholesterol44 28 24 1111.9SYP, MUC1, AMACR
16lipid448.9KRT18, SYP, MUC1, AMACR
17cysteine448.9WT1, SYP, MUC1, AMACR
18ribonucleic acid448.9WT1, ACTC1, MUC1
19forskolin44 50 1110.8MUC1, SYP, KRT18, WT1
20nitric oxide44 24 1110.8MUC1, SYP, KRT18, WT1
21zinc44 249.7AMACR, SNAI2, KRT18, WT1
22formaldehyde44 249.6MUC1, ACTC1, SYP, KRT18
23glycogen44 249.6MUC1, ACTC1, SYP, KRT18
24b 723448.6MUC1, ACTC1, SYP, WT1
25glucose448.5AMACR, MUC1, ACTC1, KRT18
26serine448.5WT1, KRT18, SYP, MUC1
27matrigel448.5KRT18, SNAI2, ACTC1, MUC1
28steroid448.4WT1, KRT18, SYP, ACTC1
29hematoxylin448.3KRT18, SYP, ACTC1, MUC1, AMACR
30dexamethasone44 50 28 1111.3KRT18, SYP, ACTC1, MUC1, AMACR
31creatinine448.0WT1, KRT18, SYP, ACTC1, MUC1
32vegf448.0MUC1, ACTC1, SYP, KRT18, WT1
33paraffin447.7AMACR, MUC1, ACTC1, SYP, KRT18, WT1
34progesterone44 28 61 24 1111.7AMACR, MUC1, ACTC1, SYP, KRT18, WT1
35testosterone44 61 24 1110.7AMACR, MUC1, ACTC1, SYP, KRT18, WT1
36retinoic acid44 248.7AMACR, MUC1, ACTC1, SYP, KRT18, WT1
37estrogen447.2AMACR, MUC1, ACTC1, SNAI2, SYP, KRT18
38tyrosine447.1AMACR, MUC1, ACTC1, SNAI2, SYP, KRT18

GO Terms for genes affiliated with Spindle Cell Carcinoma

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Cellular components related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.5SNAI2, MUC1
2cytoplasmGO:0057376.9WT1, KRT18, SNAI2, ACTC1, MUC1, AMACR

Biological processes related to Spindle Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:0430668.5WT1, KRT18, ACTC1

Products for genes affiliated with Spindle Cell Carcinoma

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Sources for Spindle Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet