MCID: SPN032
MIFTS: 43

Spindle Cell Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

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Aliases & Descriptions for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 11 13
Carcinoma, Spindle-Cell 68
 
Carcinoma Spindle Cell 50
Sarcomatoid Carcinoma 11

Classifications:



External Ids:

Disease Ontology11 DOID:4015
MeSH39 D002277
SNOMED-CT62 23109009, 65692009
NCIt45 C27004

Summaries for Spindle Cell Carcinoma

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Disease Ontology:11 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary: Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to pleomorphic carcinoma and renal cell carcinoma. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways are Striated Muscle Contraction and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include kidney, skin and lung, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:71 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

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Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic carcinoma29.0KRT14, KRT5, PGR
2renal cell carcinoma28.9AMACR, CDH1, CDH16, KRT8, MUC1, VIM
3rectum sarcomatoid carcinoma11.9
4thymus sarcomatoid carcinoma11.9
5sarcomatoid squamous cell skin carcinoma11.2
6sarcomatoid transitional cell carcinoma10.9
7sarcomatoid renal cell carcinoma10.9
8sarcomatoid penile squamous cell carcinoma10.8
9distal monosomy 7q3610.7MUC1, VIM
10transitional meningioma10.7MUC1, VIM
11lymphangiomatosis10.7ACTC1, VIM
12myxoid liposarcoma of the ovary10.7ACTC1, VIM
13iridogoniodysgenesis and skeletal anomalies10.7ACTC1, VIM
14pediculus humanus capitis infestation10.7MUC1, VIM
15subependymal giant cell astrocytoma10.7MUC1, VIM
16placental site trophoblastic tumor10.6ACTC1, MUC1
17xq12-q13.3 duplication syndrome10.6ACTC1, DES
18middle ear squamous cell carcinoma10.6CDH1, VIM
19syringoma10.6MUC1, VIM
20breast metaplastic carcinoma10.6MUC1, PGR
21harding ataxia10.6DES, VIM
22plethora of newborn10.6CDH1, MUC1
23malignant peritoneal solitary fibrous tumor10.6ACTC1, VIM
24glottis verrucous carcinoma10.6MUC1, PGR
25absence of fingerprints congenital milia10.6DES, VIM
26urethra squamous cell carcinoma10.6CDH1, VIM
27endometriosis of pelvic peritoneum10.6MUC1, PGR
28adenocarcinoma in situ10.6MUC1, PGR
29combined thymoma10.6DES, MUC1
30pancreatic delta cell neoplasm10.6DES, VIM
31subacute leukemia10.6DES, MUC1
32simple partial epilepsy10.6ACTC1, PGR
33serous surface papilloma10.6MUC1, PGR
34malignant adenofibroma10.6DES, VIM
35non-gestational choriocarcinoma10.5PGR, VIM
36white platelet syndrome10.5DES, MUC1
37hing torack dowston syndrome10.5MUC1, SYP
38fraxf syndrome10.5SYP, VIM
39pura syndrome10.5ACTC1, DES
40pleuropulmonary blastoma type 210.5ACTC1, DES
41sm-ahnmd10.5SYP, VIM
42ovarian surface papilloma10.5AMACR, MUC1, VIM
43focal facial dermal dysplasia10.5ACTC1, SYP
44skin sarcoma10.5ACTC1, MUC1, VIM
45breast malignant phyllodes tumor10.5CDH1, MUC1
46ovarian cystadenocarcinoma10.5ACTC1, MUC1, VIM
47dysembryoplastic neuroepithelial tumor10.5DES, PGR
48apocrine adenocarcinoma10.5MUC1, PGR
49gallbladder signet ring cell adenocarcinoma10.5CDH1, SYP
50dens in dente and palatal invaginations10.5ACTC1, MUC1, VIM

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to spindle cell carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

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MGI Mouse Phenotypes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.6ACTC1, CDH1, DES, KRT8, PGR, TP63
2MP:00053767.5ACTC1, AMACR, CDH1, DES, KRT14, KRT8
3MP:00107686.3ACTC1, AMACR, CDH1, DES, KRT14, KRT5

Drugs & Therapeutics for Spindle Cell Carcinoma

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Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Sunitinibapproved, investigationalPhase 2500341031-54-7, 557795-19-45329102
Synonyms:
(2S)-2-hydroxybutanedioic acid
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-, (2S)-hydroxybutanedioate (1:1)
326914-13-0
341031-54-7
5-(5-FLUORO-2-OXO-1,2-DIHYDRO-INDOL-3-YLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE
557795-19-4
AC1NS62J
AC1O5CMQ
AKOS005145765
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
CHEBI:38940
CHEBI:550864
CHEMBL1567
CHEMBL535
CID5329102
CID6456015
D06402
D08552
DB01268
DB07417
EN002687
FT-0083555
FT-0083556
I01-1229
K00588a
KS-5022
LS-186078
LS-187023
LS-187648
MolPort-003-986-763
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
 
NSC736511
NSC750690
PDGF TK antagonist
PHA-290940AD
PNU-290940AD
S1042_Selleck
ST51053712
SU 011248
SU 11248
SU-010398
SU-011248 L-malate salt
SU-11248
SU-11248 L-malate salt
SU-11248J
SU-12662
SU010398
SU011248
SU011248 L-malate salt
SU11248
Su-011248
Sunitanib
Sunitinib
Sunitinib (INN)
Sunitinib (free base)
Sunitinib malate
Sunitinib malate (JAN/USAN)
Sunitinib malate [USAN]
Sunitinibum
Sutent
Sutent (TN)
Sutent, SU-11248
TL8002546
UNII-LVX8N1UT73
UNII-V99T50803M
sunitinib
sunitinibum
2
Bevacizumabapproved, investigationalPhase 21968216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
3
GemcitabineapprovedPhase 2197495058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
4
Capecitabineapproved, investigationalPhase 21296154361-50-960953
Synonyms:
(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester
154361-50-9
158798-73-3
5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine
5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
AC1L1U83
AC1Q4KU8
Ambap154361-50-9
C110904
C12650
C15H22FN3O6
CAPE
CAPECITABINE
CHEBI:31348
CHEMBL1773
CID60953
Capecitabin
Capecitabina
Capecitabine (JAN/USAN/INN)
Capecitabine [USAN]
Capecitabinum
Capecitibine
Capiibine
Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester
Caxeta
 
D01223
DB01101
FT-0082472
HSDB 7656
LS-59070
MolPort-005-938-254
N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine
Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate
R-340
R340
RG-340
Ro 09-1978
Ro 09-1978/000
Ro-09-1978
Ro-09-1978/000
S1156_Selleck
UNII-6804DJ8Z9U
Xabine
Xeloda
Xeloda (TN)
Xeloda, Captabin, Capecitabine
ZINC03806413
capecitabina
capecitabine
capecitabinum
pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate
5
nivolumabapprovedPhase 2326946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
6
CisplatinapprovedPhase 2, Phase 1269015663-27-184093, 441203, 2767
Synonyms:
(SP-4-1)-diamminedichloridoplatinum
(SP-4-1)-diamminedichloroplatinum
(SP-4-2)-diamminedichloridoplatinum
(SP-4-2)-diamminedichloroplatinum
Abiplatin
Biocisplatinum
Briplatin
CACP
CDDP
CHEBI:35852
CID441203
CPD0-1392
CPDC
CPDD
Carboquone
Cis Pt II
Cis-DDP
Cis-Diaminedichloroplatinum
Cis-Diamminedichloroplatinum
Cismaplat
Cisplatine
Cisplatino
Cisplatinum
Cisplatyl
Citoplationo
DB00515
DDP
DDPT
Diamminedichloroplatinum
 
EU-0100918
Lederplatin
Neoplatin
Peyrone's chloride
Peyrone's salt
Plastin
Platamine
Platiblastin
Platidiam
Platinex
Platinol
Platinol-AQ
Platinoxan
Platinum Ammine Chloride
Platinum Ammonium Chloride
Platinum Diamine Dichloride
Randa
Trans-DDP
Trans-Diaminedichloroplatinum
Trans-Diamminedichloroplatinum
Trans-Dichlorodiammine Platinum
Trans-Platinumdiammine Dichloride
cis-DDP
cis-Diamminedichloroplatinum
cis-Dichlorodiammineplatinum(II)
cis-[PtCl2(NH3)2]
cis-diamminedichloridoplatinum(II)
cis-diamminedichloroplatinum(II)
nchembio773-comp1
trans-diamminedichloridoplatinum(II)
7
SuccinylcholineapprovedPhase 2161306-40-15314
Synonyms:
2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM)
2,2'-[(1,4-DIOXOBUTANE-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
2ha2
2ha6
306-40-1
4-04-00-01451 (Beilstein Handbook Reference)
541-19-5 (diiodide)
55-94-7 (dibromide)
71-27-2 (dichloride)
AC1L1K2T
Anectine
BRN 1805311
C07546
C14H30N2O4
CHEBI:45652
CHEMBL703
CID5314
Choline, succinate (2:1) (ester)
Choline, succinate (ester)
DB00202
Diacetylcholine
Dicholine succinate
Ditilin
Ditiline
HMS2090P14
HSDB 3254
InChI=1/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
L000926
LS-53328
Listenon
 
Lopac-S-8251
Lopac0_001080
Lysthenon
MolPort-002-964-486
NCGC00015971-01
NCGC00015971-03
NCGC00162336-01
Quelicin
Quelicin Preservative Free
SCK
ST50437287
STK177290
Scoline
Succicuran
Succinic acid, diester with choline
Succinic acid, diester with choline chloride
Succinocholine
Succinoylcholine
Succinyl choline
Succinylbischoline
Succinylcholine
Succinylcholine Chloride
Succinyldicholine
Sucostrin
Suxamethonium
Suxamethonium chloride
UNII-J2R869A8YF
ZINC01530820
succinylcholine
succinyldicholine
trimethyl-[2-[4-oxo-4-(2-trimethylazaniumylethoxy)butanoyl]oxyethyl]azanium diio
trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium
8
Paclitaxelapproved, vet_approvedPhase 2275833069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
9Angiogenesis InhibitorsPhase 24143
10Angiogenesis Modulating AgentsPhase 24072
11Immunosuppressive AgentsPhase 212770
12MitogensPhase 21526
13ImmunoglobulinsPhase 26045
14AntibodiesPhase 26045
15Antibodies, MonoclonalPhase 23795
16Endothelial Growth FactorsPhase 2362
17Anti-Infective AgentsPhase 221402
18AntimetabolitesPhase 211774
19Antiviral AgentsPhase 29732
20Antimetabolites, AntineoplasticPhase 27171
21Peripheral Nervous System AgentsPhase 222776
22Neuromuscular Depolarizing AgentsPhase 2135
23Neuromuscular Blocking AgentsPhase 2414
24Neuromuscular AgentsPhase 21129
25Antineoplastic Agents, PhytogenicPhase 25420
26Albumin-Bound PaclitaxelPhase 22757
27
tremelimumabPhase 294
Synonyms:
206
CP675
 
CP675206
Ticilimumab
tremelimumab
28Antimitotic AgentsPhase 25498

Interventional clinical trials:

idNameStatusNCT IDPhase
1Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell CarcinomaUnknown statusNCT01219751Phase 2
2Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell CarcinomaCompletedNCT00496587Phase 2
3Nivolumab and Ipilimumab in Treating Patients With Rare TumorsRecruitingNCT02834013Phase 2
4Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck Who Have Undergone SurgeryRecruitingNCT02734537Phase 2
5A Phase I/II Trial of Crolibulin (EPC2407) Plus Cisplatin in Adults With Solid Tumors With a Focus on Anaplastic Thyroid Cancer (ATC)Active, not recruitingNCT01240590Phase 1, Phase 2
6A Phase II Study of HMPL-504 in Lung Sarcomatoid CarcinomaNot yet recruitingNCT02897479Phase 2
7Pulmonary sarcomatoid_MEDI4736+TremeNot yet recruitingNCT03022500Phase 2
8Alisertib in Chemotherapy-pretreated Urothelial CancerNot yet recruitingNCT02109328Phase 2

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

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Anatomical Context for Spindle Cell Carcinoma

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MalaCards organs/tissues related to Spindle Cell Carcinoma:

36
Kidney, Skin, Lung, Thyroid, Tongue, Endothelial, Lymph node

Publications for Spindle Cell Carcinoma

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Articles related to Spindle Cell Carcinoma:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Spindle Cell Carcinoma of the Mandibular Gingiva - A Case Report. (27042594)
2016
2
Spindle cell carcinoma of the tongue combined with double primary cancer of the thyroid gland: a case report. (27595090)
2016
3
Spindle cell carcinoma of the conjunctiva: A rare entity. (27380985)
2016
4
Sinonasal spindle cell carcinoma presenting with bilateral visual loss: A case report and review of the literature. (27347158)
2016
5
Bi-allelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. (27604489)
2016
6
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study. (27491291)
2016
7
Spindle cell carcinoma of the breast: a comprehensive analysis. (26830716)
2016
8
CT and MR imaging features of mucinous tubular and spindle cell carcinoma of the kidneys. A multi-institutional review. (27334016)
2016
9
Spindle Cell Carcinoma of Nasal Cavity- A Case Report. (27190843)
2016
10
Spindle cell carcinoma of the esophagus: A multicenter analysis in comparison with typical squamous cell carcinoma. (27631227)
2016
11
Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. (27764039)
2016
12
Spindle cell carcinoma of the mandible: Clinicopathological and immunohistochemical characteristics. (27195215)
2016
13
Laryngeal spindle cell carcinoma: A population-based analysis of incidence and survival. (25994520)
2015
14
A Case of Granulocyte-Colony Stimulating Factor-Producing Spindle Cell Carcinoma of the Breast. (25823685)
2015
15
Wide expression of ZEB1 in sarcomatous component of spindle cell carcinoma of the esophagus. (26515382)
2015
16
Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells. (25699980)
2015
17
Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. (25785207)
2015
18
(18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. (25589812)
2015
19
Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck. (26203085)
2015
20
Osseous Metaplasia in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Case of Massive, Bilateral Tumors. (26347846)
2015
21
An Autopsy Case of Rapidly Progressing Spindle Cell Carcinoma of the Lung Accompanied with Intratumor Hemorrhage. (26558362)
2015
22
Renal mucinous tubular and spindle cell carcinoma: report of four cases and literature review. (26045827)
2015
23
Low-Grade Fibromatosis-like Spindle Cell Carcinoma of the Breast. (25822766)
2015
24
Expression of p40 and laminin 332 in metaplastic spindle cell carcinoma of the breast compared with other malignant spindle cell tumours. (25795733)
2015
25
Spindle cell carcinoma arising at the buccal mucosa: a case report and review of the literature. (25547144)
2015
26
Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. (25713418)
2015
27
Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician. (26788392)
2015
28
Comparative study of CT appearances in mucinous tubular and spindle cell carcinoma and collecting duct carcinoma of the kidney. (26435393)
2015
29
Mucinous tubular and spindle cell carcinoma of kidney: A case report of an unusual tumor. (26458668)
2015
30
Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms undergoing epithelial-mesenchymal transition. (25420898)
2015
31
Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients. (26635898)
2015
32
Mucinous tubular and spindle cell carcinoma of the kidney: Diagnosis by fine needle aspiration and review of the literature. (26884801)
2015
33
Clinicopathological characteristics of kidney mucinous tubular and spindle cell carcinoma. (25755810)
2015
34
Cutaneous spindle cell carcinoma misdiagnosed as atypical fibroxanthoma based on immunohistochemical stains. (27051790)
2015
35
Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. (24634155)
2014
36
Spindle cell carcinoma of the breast as complex cystic lesion: a case report. (25009755)
2014
37
Spindle cell carcinoma of the tongue: a rare variant of squamous cell carcinoma. (25114719)
2014
38
Clear cell changes in mucinous tubular and spindle cell carcinoma: cytoplasmic pallor/clearing within tubules, vacuoles or hybrid conventional clear cell carcinoma of kidney? (25120820)
2014
39
Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney: A Retrospective Detailed Study of Radiologic, Pathologic and Clinical Outcomes. (25395040)
2014
40
Mucinous tubular and spindle cell carcinoma of the kidney: a rare case diagnosed in the early postpartum. (24619013)
2014
41
HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast. (25309767)
2014
42
Mucinous, tubular and spindle cell carcinoma of kidney: report of two cases with pathological differences. (25407154)
2014
43
Contrast-enhanced ultrasound characterization of renal mucinous tubular and spindle cell carcinoma: Report of two cases. (24706525)
2014
44
Spindle cell carcinoma of the breast in a patient with neurofibromatosis type 1. (24941449)
2014
45
Sarcomatoid variant of urothelial carcinoma (carcinosarcoma, spindle cell carcinoma): a review of the literature. (24587922)
2014
46
Clinical and CT imaging features of mucinous tubular and spindle cell carcinoma. (24709180)
2014
47
Spindle cell carcinoma of maxilla: Histomorphological and immunohistochemical analysis of a case. (25328308)
2014
48
Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. (25013496)
2014
49
Management of spindle cell carcinoma of the maxillary sinus: a case report and literature review. (25350698)
2014
50
Sarcomatoid (spindle cell) carcinoma of the pancreas: A case report and review of the literature. (24348857)
2014

Variations for Spindle Cell Carcinoma

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Cosmic variations for Spindle Cell Carcinoma:

8 (show all 18)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM10988TP53skin,face,carcinoma,squamous cell carcinomac.772G>Ap.E258K9
2COSM43588TP53skin,face,carcinoma,squamous cell carcinomac.740A>Cp.N247T9
3COSM520KRASskin,face,carcinoma,squamous cell carcinomac.35G>Tp.G12V9
4COSM585NRASskin,face,carcinoma,squamous cell carcinomac.183A>Tp.Q61H9
5COSM43582TP53skin,face,carcinoma,squamous cell carcinomac.454C>Tp.P152S9
6COSM564NRASskin,face,carcinoma,squamous cell carcinomac.35G>Ap.G12D9
7COSM483HRASskin,face,carcinoma,squamous cell carcinomac.35G>Tp.G12V9
8COSM498HRASskin,face,carcinoma,squamous cell carcinomac.182A>Tp.Q61L9
9COSM521KRASskin,hand,carcinoma,squamous cell carcinomac.35G>Ap.G12D9
10COSM10726TP53skin,face,carcinoma,squamous cell carcinomac.856G>Ap.E286K9
11COSM10656TP53skin,face,carcinoma,squamous cell carcinomac.742C>Tp.R248W9
12COSM17489PTCH1skin,face,carcinoma,squamous cell carcinomac.3724G>Ap.E1242K9
13COSM10939TP53skin,face,carcinoma,squamous cell carcinomac.832C>Tp.P278S9
14COSM43665TP53skin,face,carcinoma,squamous cell carcinomac.746G>Cp.R249T9
15COSM11081TP53skin,face,carcinoma,squamous cell carcinomac.733G>Tp.G245C9
16COSM574NRASskin,face,carcinoma,squamous cell carcinomac.38G>Tp.G13V9
17COSM10733TP53skin,face,carcinoma,squamous cell carcinomac.574C>Tp.Q192*9
18COSM10654TP53skin,face,carcinoma,squamous cell carcinomac.637C>Tp.R213*9

Expression for genes affiliated with Spindle Cell Carcinoma

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Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for genes affiliated with Spindle Cell Carcinoma

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Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6ACTC1, DES, VIM
2
Show member pathways
8.1DES, KRT14, KRT5, KRT8, VIM
38.0ACTC1, CDH1, DES, KRT5, KRT8, VIM

GO Terms for genes affiliated with Spindle Cell Carcinoma

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Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450958.7KRT14, KRT5, KRT8
2intermediate filamentGO:00058828.6DES, KRT14, KRT5, KRT8, VIM
3cytoplasmGO:00057377.0ACTC1, AMACR, CDH1, DES, KRT14, KRT5
4extracellular exosomeGO:00700627.0ACTC1, CDH1, CDH16, DES, KRT14, KRT5

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.4MUC1, TP63
2intermediate filament organizationGO:004510910.3DES, VIM
3hemidesmosome assemblyGO:00315819.7KRT14, KRT5
4muscle filament slidingGO:00300499.6ACTC1, DES, VIM
5epithelial cell differentiationGO:00308559.5KRT14, MUC1, TP63
6epidermis developmentGO:00085449.4KRT14, KRT5, TP63

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filament bindingGO:199025410.0KRT14, VIM
2scaffold protein bindingGO:00971109.8KRT5, KRT8, VIM
3structural constituent of cytoskeletonGO:00052008.6DES, KRT14, KRT5, VIM

Sources for Spindle Cell Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet