SCH
MCID: SPN012
MIFTS: 39

Spindle Cell Hemangioma (SCH) malady

Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases categories

Summaries for Spindle Cell Hemangioma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to hemangioma and hemangioendothelioma. An important gene associated with Spindle Cell Hemangioma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Peroxisome and Citric acid cycle (TCA cycle). The compounds Oxalosuccinic acid and Isocitric acid have been mentioned in the context of this disorder. Affiliated tissues include bone and cervix.

Aliases & Classifications for Spindle Cell Hemangioma

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9Disease Ontology, 11DISEASES, 50Orphanet, 63UMLS, 41NCIt, 59SNOMED-CT, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Aliases & Descriptions:

spindle cell hemangioma 9 11 50 63
spindle cell hemangioendothelioma 9 50
spindle cell angioendothelioma 9
sch 9


External Ids:

Disease Ontology9 DOID:496
NCIt41 C4754
ICD10 via Orphanet27 D18.0
SNOMED-CT via Orphanet60 128769003, 403967000
UMLS via Orphanet64 C1304508

Related Diseases for Spindle Cell Hemangioma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Symptoms for Spindle Cell Hemangioma

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Drugs & Therapeutics for Spindle Cell Hemangioma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spindle Cell Hemangioma

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Anatomical Context for Spindle Cell Hemangioma

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34MalaCards
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MalaCards organs/tissues related to Spindle Cell Hemangioma:

34
Bone, Cervix

Animal Models for Spindle Cell Hemangioma or affiliated genes

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Publications for Spindle Cell Hemangioma

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53PubMed
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Articles related to Spindle Cell Hemangioma:

(show all 14)
idTitleAuthorsYear
1
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
2
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
3
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
4
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
5
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
6
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. (20860749)
2010
7
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
8
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
9
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
10
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
11
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
12
Spindle cell hemangioma. (12859394)
2003
13
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
14
Spindle cell hemangioma. (10592415)
1999

Variations for Spindle Cell Hemangioma

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Expression for genes affiliated with Spindle Cell Hemangioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Hemangioma

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Pathways for genes affiliated with Spindle Cell Hemangioma

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IDH1, IDH2
2
Show member pathways
TCA cycle39
pyruvate decarboxylation to acetyl CoA39
NAD phosphorylation and dephosphorylation39
TCA Cycle39
conversion of glucose to acetyl CoA and entry into the TCA cycle39
9.9IDH1, IDH2
3
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
9.9IDH1, IDH2
4
Show member pathways
Alzheimers Disease39
9.0ATP5G1, ATP5G2, ATP5G3
5
Show member pathways
8.7IDH2, ATP5G1, ATP5G2, ATP5G3
6
Show member pathways
8.4ATP5G3, ATP5G2, ATP5G1, IDH2, IDH1

Compounds for genes affiliated with Spindle Cell Hemangioma

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25HMDB, 12DrugBank, 46Novoseek
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Compounds related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid259.9IDH1, IDH2
2Isocitric acid25 1210.9IDH1, IDH2
3carbon dioxide46 2510.9IDH1, IDH2
4isocitrate469.8IDH2, IDH1
5Oxoglutaric acid259.6IDH1, IDH2

GO Terms for genes affiliated with Spindle Cell Hemangioma

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17Gene Ontology
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Cellular components related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057399.1IDH1, IDH2, BNIP1, ATP5G1
2proton-transporting ATP synthase complex, coupling factor F(o)GO:0452638.9ATP5G1, ATP5G2, ATP5G3
3mitochondrial proton-transporting ATP synthase complexGO:0057538.7ATP5G3, ATP5G2, ATP5G1

Biological processes related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:0060979.9IDH1, IDH2
2isocitrate metabolic processGO:0061029.9IDH2, IDH1
3tricarboxylic acid cycleGO:0060999.9IDH1, IDH2
42-oxoglutarate metabolic processGO:0061039.6IDH1, IDH2
5ATP synthesis coupled proton transportGO:0159869.2ATP5G2, ATP5G3
6ATP hydrolysis coupled proton transportGO:0159919.1ATP5G1, ATP5G2, ATP5G3

Molecular functions related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH1, IDH2
2NAD bindingGO:0512879.6IDH1, IDH2
3chaperone bindingGO:0510879.3BAG1, BAG2
4magnesium ion bindingGO:0002879.2IDH1, IDH2, TESC
5hydrogen ion transmembrane transporter activityGO:0150789.1ATP5G1, ATP5G2, ATP5G3
6lipid bindingGO:0082899.1ATP5G1, ATP5G2, ATP5G3
7transporter activityGO:0052159.0ATP5G3, ATP5G2, ATP5G1

Products for genes affiliated with Spindle Cell Hemangioma

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Sources for Spindle Cell Hemangioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet