SCH
MCID: SPN012
MIFTS: 37

Spindle Cell Hemangioma (SCH) malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Spindle Cell Hemangioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to hemangioma and blastomycosis. An important gene associated with Spindle Cell Hemangioma is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are Citric acid cycle (TCA cycle) and 2-Oxocarboxylic acid metabolism. The compounds isocitrate and Isocitric Acid have been mentioned in the context of this disorder. Affiliated tissues include bone and cervix.

Aliases & Classifications for Spindle Cell Hemangioma

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

spindle cell hemangioma 8 10 48 60
spindle cell hemangioendothelioma 8 48
spindle cell angioendothelioma 8
sch 8


External Ids:

Disease Ontology8 DOID:496
NCIt39 C4754
ICD10 via Orphanet26 D18.0
SNOMED-CT via Orphanet57 128769003, 403967000
UMLS via Orphanet61 C1304508

Related Diseases for Spindle Cell Hemangioma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Clinical Features for Spindle Cell Hemangioma

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Drugs & Therapeutics for Spindle Cell Hemangioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spindle Cell Hemangioma

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Anatomical Context for Spindle Cell Hemangioma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Hemangioma:

32
Bone, Cervix

Animal Models for Spindle Cell Hemangioma or affiliated genes

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Publications for Spindle Cell Hemangioma

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50PubMed
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Articles related to Spindle Cell Hemangioma:

(show all 15)
idTitleAuthorsYear
1
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
2
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
3
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
4
Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall. (23227905)
2012
5
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
6
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
7
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. (20860749)
2010
8
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
9
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
10
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
11
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
12
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
13
Spindle cell hemangioma. (12859394)
2003
14
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
15
Spindle cell hemangioma. (10592415)
1999

Genetic Variations for Spindle Cell Hemangioma

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Expression for genes affiliated with Spindle Cell Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Hemangioma

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Pathways for genes affiliated with Spindle Cell Hemangioma

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Spindle Cell Hemangioma

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1isocitrate449.9IDH2, IDH1
2Isocitric Acid11 2410.6IDH2, IDH1

GO Terms for genes affiliated with Spindle Cell Hemangioma

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16Gene Ontology
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Cellular components related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial proton-transporting ATP synthase complexGO:0057538.7ATP5G3, ATP5G1, ATP5G2
2proton-transporting ATP synthase complex, coupling factor F(o)GO:0452638.4ATP5G3, ATP5G1, ATP5G2

Biological processes related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:0060979.9IDH2, IDH1
2isocitrate metabolic processGO:0061029.9IDH2, IDH1
3tricarboxylic acid cycleGO:0060999.9IDH1, IDH2
42-oxoglutarate metabolic processGO:0061039.6IDH1, IDH2
5ATP synthesis coupled proton transportGO:0159868.9ATP5G3, ATP5G2
6ATP hydrolysis coupled proton transportGO:0159918.8ATP5G2, ATP5G1, ATP5G3

Molecular functions related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH2, IDH1
2chaperone bindingGO:0510879.6BAG1, BAG2
3NAD bindingGO:0512879.6IDH2, IDH1
4magnesium ion bindingGO:0002879.2TESC, IDH2, IDH1
5hydrogen ion transmembrane transporter activityGO:0150788.8ATP5G3, ATP5G1, ATP5G2
6lipid bindingGO:0082898.8ATP5G3, ATP5G1, ATP5G2
7transporter activityGO:0052158.7ATP5G2, ATP5G1, ATP5G3

Products for genes affiliated with Spindle Cell Hemangioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Spindle Cell Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet