MCID: SPN012
MIFTS: 31

Spindle Cell Hemangioma malady

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Spindle Cell Hemangioma

About this section
Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 66UMLS, 43NCIt, 29ICD10 via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 11 13 52 66
Spindle Cell Hemangioendothelioma 11 52
 
Spindle Cell Angioendothelioma 11
Sch 11

Classifications:



External Ids:

Disease Ontology11 DOID:496
NCIt43 C4754
Orphanet52 ORPHA210584
ICD10 via Orphanet29 D18.0
UMLS via Orphanet67 C1304508

Summaries for Spindle Cell Hemangioma

About this section
Wikipedia:69 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards based summary: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to hemangioendothelioma and hemangioma. An important gene associated with Spindle Cell Hemangioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways are Citrate cycle (TCA cycle) and Peroxisome. Affiliated tissues include cervix, thyroid and bone, and related mouse phenotype growth/size/body region.

Related Diseases for Spindle Cell Hemangioma

About this section

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma10.7
2hemangioma10.5
3subserous uterine fibroid10.5IDH1, IDH2
4spinal cord disease10.5IDH1, IDH2
5endomyocardial fibroelastosis10.5IDH1, IDH2
6cystinosis, nephropathic10.5IDH1, IDH2
7maxillary sinus squamous cell carcinoma10.5IDH1, IDH2
8anaplastic small cell lymphoma10.5IDH1, IDH2
9dyserythropoietic anemia and thrombocytopenia10.5IDH1, IDH2
10gliofibroma10.4IDH1, IDH2
11benign breast phyllodes tumor10.4IDH1, IDH2
12juvenile astrocytoma10.4IDH1, IDH2
13intrahepatic bile duct cystadenoma10.4IDH1, IDH2
14capgras syndrome10.4IDH1, IDH2
15early myoclonic encephalopathy10.4IDH1, IDH2
16kernicterus due to isoimmunization10.4IDH1, IDH2
17vascular cancer10.4IDH1, IDH2
18brachydactyly10.4IDH1, IDH2
19papillary thymic adenocarcinoma10.3IDH1, IDH2
20protoplasmic astrocytoma10.3IDH1, IDH2
21fryns macrocephaly10.3IDH1, IDH2
22peripheral osteosarcoma10.3IDH1, IDH2
23neuropathy, ataxia, and retinitis pigmentosa10.2IDH1, IDH2
24d-2-hydroxyglutaric aciduria10.2IDH1, IDH2
25spinal cord oligodendroglioma10.1IDH1, IDH2
26trichorhinophalangeal syndrome, type ii10.1IDH1, IDH2
27blastomycosis10.0
28nasal cavity adenocarcinoma10.0IDH1, IDH2
29purpura9.9
30neuronitis9.9
31giant cell glioblastoma9.8IDH1, IDH2
32lymphedema9.8
33thyroiditis9.8
34periostitis9.8
35enchondroma9.8
36epithelioid hemangioendothelioma9.8
37hepatitis c virus9.7
38insulin-like growth factor i9.7
39gastric cancer9.7
40hepatitis9.7
41malignant glioma9.7
42fusariosis9.7
43congenital hypothyroidism9.7
44prostatic hypertrophy9.7
45tinea cruris9.7
46tinea corporis9.7
47paracoccidioidomycosis9.7
48coccidioidomycosis9.7
49phaeohyphomycosis9.7
50hypothyroidism9.7

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Symptoms for Spindle Cell Hemangioma

About this section

Drugs & Therapeutics for Spindle Cell Hemangioma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

About this section

Anatomical Context for Spindle Cell Hemangioma

About this section

MalaCards organs/tissues related to Spindle Cell Hemangioma:

34
Cervix, Thyroid, Bone

Animal Models for Spindle Cell Hemangioma or affiliated genes

About this section

MGI Mouse Phenotypes related to Spindle Cell Hemangioma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.3ADARB1, DSG4, GPR161, IDH1, NPY2R, PROX1

Publications for Spindle Cell Hemangioma

About this section

Articles related to Spindle Cell Hemangioma:

(show all 22)
idTitleAuthorsYear
1
Multifocal spindle cell hemangioma: Report of two cases. (26728826)
2016
2
Intramedullary spindle cell hemangioma: case report. (27058496)
2016
3
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. (26945705)
2016
4
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. (26980977)
2015
5
Spindle cell hemangioma of thyroid. (26905134)
2015
6
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. (24673328)
2014
7
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. (23485734)
2013
8
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
9
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. (23506121)
2013
10
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
11
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
12
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
13
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
14
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. (20860749)
2010
15
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
16
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
17
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
18
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
19
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
20
Spindle cell hemangioma. (12859394)
2003
21
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
22
Spindle cell hemangioma. (10592415)
1999

Variations for Spindle Cell Hemangioma

About this section

Expression for genes affiliated with Spindle Cell Hemangioma

About this section
Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for genes affiliated with Spindle Cell Hemangioma

About this section

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8IDH1, IDH2
29.8IDH1, IDH2

GO Terms for genes affiliated with Spindle Cell Hemangioma

About this section

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:000609710.2IDH1, IDH2
2isocitrate metabolic processGO:000610210.2IDH1, IDH2
32-oxoglutarate metabolic processGO:00061039.8IDH1, IDH2
4tricarboxylic acid cycleGO:00060999.5IDH1, IDH2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase activityGO:000444810.1IDH1, IDH2
2isocitrate dehydrogenase (NADP+) activityGO:000445010.1IDH1, IDH2
3NAD bindingGO:00512879.8IDH1, IDH2

Sources for Spindle Cell Hemangioma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet