SCH
MCID: SPN012
MIFTS: 39

Spindle Cell Hemangioma (SCH) malady

Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases categories

Summaries for Spindle Cell Hemangioma

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Wikipedia:64 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards based summary: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to hemangioma and hemangioendothelioma. An important gene associated with Spindle Cell Hemangioma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Peroxisome and Citric acid cycle (TCA cycle). The compounds Oxalosuccinic acid and Isocitric acid have been mentioned in the context of this disorder. Affiliated tissues include bone and cervix.

Aliases & Classifications for Spindle Cell Hemangioma

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Sources:
9Disease Ontology, 11DISEASES, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Spindle Cell Hemangioma, Aliases & Descriptions:

Name: Spindle Cell Hemangioma 9 11 48 61
Spindle Cell Hemangioendothelioma 9 48
Spindle Cell Angioendothelioma 9 61
 
Spindle Cell Haemangioendothelioma 61
Sch 9


Classifications:



External Ids:

Disease Ontology9 DOID:496
NCIt39 C4754
ICD10 via Orphanet27 D18.0
UMLS via Orphanet62 C1304508

Related Diseases for Spindle Cell Hemangioma

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Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Symptoms for Spindle Cell Hemangioma

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Drugs & Therapeutics for Spindle Cell Hemangioma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Hemangioma

Search NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

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Anatomical Context for Spindle Cell Hemangioma

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MalaCards organs/tissues related to Spindle Cell Hemangioma:

32
Bone, Cervix

Animal Models for Spindle Cell Hemangioma or affiliated genes

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Publications for Spindle Cell Hemangioma

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Articles related to Spindle Cell Hemangioma:

(show all 15)
idTitleAuthorsYear
1
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. (24673328)
2014
2
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. (23485734)
2013
3
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
4
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
5
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
6
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
7
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
8
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
9
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
10
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
11
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
12
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
13
Spindle cell hemangioma. (12859394)
2003
14
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
15
Spindle cell hemangioma. (10592415)
1999

Variations for Spindle Cell Hemangioma

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Expression for genes affiliated with Spindle Cell Hemangioma

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Expression patterns in normal tissues for genes affiliated with Spindle Cell Hemangioma

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Pathways for genes affiliated with Spindle Cell Hemangioma

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Pathways related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IDH1, IDH2
2
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.9IDH1, IDH2
3
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism59
Glutathione metabolism37
9.9IDH1, IDH2
4
Show member pathways
Alzheimers Disease37
9.0ATP5G1, ATP5G2, ATP5G3
5
Show member pathways
8.7IDH2, ATP5G1, ATP5G2, ATP5G3
6
Show member pathways
8.4ATP5G3, ATP5G2, ATP5G1, IDH2, IDH1

Compounds for genes affiliated with Spindle Cell Hemangioma

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Sources:
25HMDB, 12DrugBank, 44Novoseek
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Compounds related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid259.9IDH1, IDH2
2Isocitric acid25 1210.9IDH1, IDH2
3carbon dioxide44 2510.9IDH1, IDH2
4isocitrate449.8IDH2, IDH1
5Oxoglutaric acid259.6IDH1, IDH2

GO Terms for genes affiliated with Spindle Cell Hemangioma

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Cellular components related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057399.1IDH1, IDH2, BNIP1, ATP5G1
2proton-transporting ATP synthase complex, coupling factor F(o)GO:0452638.9ATP5G1, ATP5G2, ATP5G3
3mitochondrial proton-transporting ATP synthase complexGO:0057538.7ATP5G3, ATP5G2, ATP5G1

Biological processes related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:0060979.9IDH1, IDH2
2isocitrate metabolic processGO:0061029.9IDH2, IDH1
3tricarboxylic acid cycleGO:0060999.9IDH1, IDH2
42-oxoglutarate metabolic processGO:0061039.6IDH1, IDH2
5ATP synthesis coupled proton transportGO:0159869.2ATP5G2, ATP5G3
6ATP hydrolysis coupled proton transportGO:0159919.1ATP5G1, ATP5G2, ATP5G3

Molecular functions related to Spindle Cell Hemangioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:00445010.0IDH1, IDH2
2NAD bindingGO:0512879.6IDH1, IDH2
3chaperone bindingGO:0510879.3BAG1, BAG2
4magnesium ion bindingGO:0002879.2IDH1, IDH2, TESC
5hydrogen ion transmembrane transporter activityGO:0150789.1ATP5G1, ATP5G2, ATP5G3
6lipid bindingGO:0082899.1ATP5G1, ATP5G2, ATP5G3
7transporter activityGO:0052159.0ATP5G3, ATP5G2, ATP5G1

Products for genes affiliated with Spindle Cell Hemangioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Spindle Cell Hemangioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet