MCID: SPN012
MIFTS: 30

Spindle Cell Hemangioma malady

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Spindle Cell Hemangioma

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Sources:
11Disease Ontology, 13DISEASES, 31ICD10 via Orphanet, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 11 54 13 68
Spindle Cell Hemangioendothelioma 11 54
 
Spindle Cell Angioendothelioma 11
Sch 11

Classifications:



External Ids:

Disease Ontology11 DOID:496
NCIt45 C4754
Orphanet54 ORPHA210584
UMLS via Orphanet69 C1304508
ICD10 via Orphanet31 D18.0

Summaries for Spindle Cell Hemangioma

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Wikipedia:71 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards based summary: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to subserous uterine fibroid and spinal cord disease. An important gene associated with Spindle Cell Hemangioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways are Citrate cycle (TCA cycle) and Peroxisome. Affiliated tissues include cervix, thyroid and bone.

Related Diseases for Spindle Cell Hemangioma

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Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1subserous uterine fibroid10.4IDH1, IDH2
2spinal cord disease10.4IDH1, IDH2
3endomyocardial fibroelastosis10.4IDH1, IDH2
4cystinosis, nephropathic10.4IDH1, IDH2
5maxillary sinus squamous cell carcinoma10.4IDH1, IDH2
6anaplastic small cell lymphoma10.4IDH1, IDH2
7dyserythropoietic anemia and thrombocytopenia10.4IDH1, IDH2
8gliofibroma10.4IDH1, IDH2
9benign breast phyllodes tumor10.4IDH1, IDH2
10juvenile astrocytoma10.4IDH1, IDH2
11hemangioma10.4
12intrahepatic bile duct cystadenoma10.4IDH1, IDH2
13capgras syndrome10.4IDH1, IDH2
14early myoclonic encephalopathy10.4IDH1, IDH2
15kernicterus due to isoimmunization10.3IDH1, IDH2
16vascular cancer10.3IDH1, IDH2
17brachydactyly10.3IDH1, IDH2
18papillary thymic adenocarcinoma10.3IDH1, IDH2
19protoplasmic astrocytoma10.3IDH1, IDH2
20fryns macrocephaly10.2IDH1, IDH2
21peripheral osteosarcoma10.2IDH1, IDH2
22neuropathy, ataxia, and retinitis pigmentosa10.1IDH1, IDH2
23nasal cavity adenocarcinoma10.1IDH1, IDH2
24d-2-hydroxyglutaric aciduria10.0IDH1, IDH2
25hemangioendothelioma10.0
26blastomycosis9.9
27spinal cord oligodendroglioma9.9IDH1, IDH2
28purpura9.7
29neuronitis9.7
30lymphedema9.7
31thyroiditis9.7
32periostitis9.7
33enchondroma9.7
34epithelioid hemangioendothelioma9.7
35hepatitis c virus9.6
36insulin-like growth factor i9.6
37gastric cancer9.6
38hepatitis9.6
39malignant glioma9.6
40fusariosis9.6
41congenital hypothyroidism9.6
42prostatic hypertrophy9.6
43tinea cruris9.6
44tinea corporis9.6
45paracoccidioidomycosis9.6
46coccidioidomycosis9.6
47phaeohyphomycosis9.6
48hypothyroidism9.6
49prostatitis9.6
50hepatitis c9.6

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

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Drugs & Therapeutics for Spindle Cell Hemangioma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

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Anatomical Context for Spindle Cell Hemangioma

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MalaCards organs/tissues related to Spindle Cell Hemangioma:

36
Cervix, Thyroid, Bone

Publications for Spindle Cell Hemangioma

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Articles related to Spindle Cell Hemangioma:

(show all 22)
idTitleAuthorsYear
1
Multifocal spindle cell hemangioma: Report of two cases. (26728826)
2016
2
Intramedullary spindle cell hemangioma: case report. (27058496)
2016
3
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. (26945705)
2016
4
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. (26980977)
2015
5
Spindle cell hemangioma of thyroid. (26905134)
2015
6
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. (24673328)
2014
7
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. (23485734)
2013
8
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
9
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. (23506121)
2013
10
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
11
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
12
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
13
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
14
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. (20860749)
2010
15
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
16
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
17
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
18
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
19
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
20
Spindle cell hemangioma. (12859394)
2003
21
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
22
Spindle cell hemangioma. (10592415)
1999

Variations for Spindle Cell Hemangioma

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Expression for genes affiliated with Spindle Cell Hemangioma

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Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for genes affiliated with Spindle Cell Hemangioma

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Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8IDH1, IDH2
29.8IDH1, IDH2

GO Terms for genes affiliated with Spindle Cell Hemangioma

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Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
12-oxoglutarate metabolic processGO:000610310.4IDH1, IDH2
2glyoxylate cycleGO:000609710.4IDH1, IDH2
3isocitrate metabolic processGO:000610210.4IDH1, IDH2
4tricarboxylic acid cycleGO:00060999.8IDH1, IDH2
5regulation of catalytic activityGO:00507909.7BAG1, BAG2
6regulation of cellular response to heatGO:19000349.5BAG1, BAG2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:000445010.3IDH1, IDH2
2isocitrate dehydrogenase activityGO:000444810.2IDH1, IDH2
3NAD bindingGO:00512879.8IDH1, IDH2
4adenyl-nucleotide exchange factor activityGO:00007749.7BAG1, BAG2
5chaperone bindingGO:00510879.6BAG1, BAG2

Sources for Spindle Cell Hemangioma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet