SCH
MCID: SPN012
MIFTS: 30

Spindle Cell Hemangioma (SCH) malady

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Spindle Cell Hemangioma

About this section
Sources:
11Disease Ontology, 13DISEASES, 31ICD10 via Orphanet, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 11 54 13 68
Spindle Cell Hemangioendothelioma 11 54
 
Spindle Cell Angioendothelioma 11
Sch 11

Classifications:



External Ids:

Disease Ontology11 DOID:496
NCIt45 C4754
Orphanet54 ORPHA210584
UMLS via Orphanet69 C1304508
ICD10 via Orphanet31 D18.0

Summaries for Spindle Cell Hemangioma

About this section
Wikipedia:71 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards based summary: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to hemangioendothelioma and hemangioma. An important gene associated with Spindle Cell Hemangioma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways are Peroxisome and Cytosine methylation. Affiliated tissues include cervix, thyroid and bone.

Related Diseases for Spindle Cell Hemangioma

About this section

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma11.3
2hemangioma10.4
3optic disk drusen10.2IDH1, IDH2
4enterovesical fistula10.2IDH1, IDH2
5acrocallosal syndrome10.2IDH1, IDH2
6neurilemmoma10.2IDH1, IDH2
7testis refractory cancer10.2IDH1, IDH2
8cystinosis, nephropathic10.2IDH1, IDH2
9small cell osteogenic sarcoma10.2IDH1, IDH2
10glycogen storage disease type 010.2IDH1, IDH2
11angioma hereditary neurocutaneous10.2IDH1, IDH2
12neuropathy, ataxia, and retinitis pigmentosa10.2IDH1, IDH2
13breast papillomatosis10.2IDH1, IDH2
14spinal cord astrocytoma10.2IDH1, IDH2
15cystic lymphangioma10.2IDH1, IDH2
16agammaglobulinemia 8, autosomal dominant10.2IDH1, IDH2
17gummatous syphilis10.2IDH1, IDH2
18amyloid tumor10.2IDH1, IDH2
19t-cell adult acute lymphocytic leukemia10.2IDH1, IDH2
20allergic hypersensitivity disease10.1IDH1, IDH2
21vascular cancer10.1IDH1, IDH2
22asynchronous multifocal osteogenic sarcoma10.1IDH1, IDH2
23systemic lupus erythematosus 210.1IDH1, IDH2
24macrosomia with microphthalmia, lethal10.1IDH1, IDH2
25basophilic carcinoma10.0IDH1, IDH2
26blastomycosis9.9
27purpura9.7
28neuronitis9.7
29lymphedema9.7
30thyroiditis9.7
31periostitis9.7
32enchondroma9.7
33epithelioid hemangioendothelioma9.7
34hepatitis c virus9.6
35insulin-like growth factor i9.6
36gastric cancer9.6
37hepatitis9.6
38malignant glioma9.6
39fusariosis9.6
40congenital hypothyroidism9.6
41prostatic hypertrophy9.6
42tinea cruris9.6
43tinea corporis9.6
44paracoccidioidomycosis9.6
45coccidioidomycosis9.6
46phaeohyphomycosis9.6
47hypothyroidism9.6
48prostatitis9.6
49hepatitis c9.6
50giant cell tumor9.6

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

About this section

Drugs & Therapeutics for Spindle Cell Hemangioma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

About this section

Anatomical Context for Spindle Cell Hemangioma

About this section

MalaCards organs/tissues related to Spindle Cell Hemangioma:

36
Cervix, Thyroid, Bone

Publications for Spindle Cell Hemangioma

About this section

Articles related to Spindle Cell Hemangioma:

(show all 22)
idTitleAuthorsYear
1
Intramedullary spindle cell hemangioma: case report. (27058496)
2016
2
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. (26945705)
2016
3
Multifocal spindle cell hemangioma: Report of two cases. (26728826)
2016
4
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. (26980977)
2015
5
Spindle cell hemangioma of thyroid. (26905134)
2015
6
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. (24673328)
2014
7
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. (23506121)
2013
8
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
9
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. (23485734)
2013
10
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
11
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
12
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
13
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
14
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. (20860749)
2010
15
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
16
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
17
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
18
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
19
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
20
Spindle cell hemangioma. (12859394)
2003
21
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
22
Spindle cell hemangioma. (10592415)
1999

Variations for Spindle Cell Hemangioma

About this section

Expression for genes affiliated with Spindle Cell Hemangioma

About this section
Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for genes affiliated with Spindle Cell Hemangioma

About this section

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8IDH1, IDH2
2
Show member pathways
9.8IDH1, IDH2

GO Terms for genes affiliated with Spindle Cell Hemangioma

About this section

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
12-oxoglutarate metabolic processGO:000610310.3IDH1, IDH2
2glyoxylate cycleGO:000609710.3IDH1, IDH2
3isocitrate metabolic processGO:000610210.3IDH1, IDH2
4tricarboxylic acid cycleGO:00060999.8IDH1, IDH2
5regulation of cellular response to heatGO:19000349.5BAG1, BAG2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:000445010.3IDH1, IDH2
2isocitrate dehydrogenase activityGO:000444810.3IDH1, IDH2
3NAD bindingGO:005128710.2IDH1, IDH2
4oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorGO:00166169.8IDH1, IDH2
5adenyl-nucleotide exchange factor activityGO:00007749.6BAG1, BAG2

Sources for Spindle Cell Hemangioma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet