MCID: SPN012
MIFTS: 30

Spindle Cell Hemangioma

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Spindle Cell Hemangioma

MalaCards integrated aliases for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 12 55 14 69
Sch 12 72
Spindle Cell Hemangioendothelioma 55

Classifications:



External Ids:

Disease Ontology 12 DOID:496
NCIt 46 C4754
Orphanet 55 ORPHA210584
UMLS via Orphanet 70 C1304508
ICD10 via Orphanet 33 D18.0
UMLS 69 C1304508

Summaries for Spindle Cell Hemangioma

MalaCards based summary : Spindle Cell Hemangioma, also known as sch, is related to multiple enchondromatosis, maffucci type and enchondroma. An important gene associated with Spindle Cell Hemangioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways/superpathways are Peroxisome and Cytosine methylation. Affiliated tissues include cervix, thyroid and bone.

Wikipedia : 72 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 multiple enchondromatosis, maffucci type 30.4 IDH1 IDH2
2 enchondroma 30.2 IDH1 IDH2
3 enchondromatosis, multiple, ollier type 29.9 IDH1 IDH2
4 hemangioendothelioma 11.4
5 hemangioma 10.5
6 interval angle-closure glaucoma 10.4 IDH1 IDH2
7 adult oligodendroglioma 10.4 IDH1 IDH2
8 intracranial chondrosarcoma 10.4 IDH1 IDH2
9 glioma susceptibility 1 10.3 IDH1 IDH2
10 anaplastic oligodendroglioma 10.3 IDH1 IDH2
11 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
12 chondroblastic osteosarcoma 10.3 IDH1 IDH2
13 intraductal papilloma 10.3 IDH1 IDH2
14 periosteal chondrosarcoma 10.3 IDH1 IDH2
15 adult astrocytic tumour 10.3 IDH1 IDH2
16 fibrillary astrocytoma 10.3 IDH1 IDH2
17 undifferentiated pleomorphic sarcoma 10.3 IDH1 IDH2
18 drug-induced mental disorder 10.3 IDH1 IDH2
19 drug psychosis 10.3 IDH1 IDH2
20 diffuse infiltrative lymphocytosis syndrome 10.2 IDH1 IDH2
21 2-hydroxyglutaric aciduria 10.2 IDH1 IDH2
22 breast papillary carcinoma 10.2 IDH1 IDH2
23 d-2-hydroxyglutaric aciduria 1 10.2 IDH1 IDH2
24 bile duct adenocarcinoma 10.1 IDH1 IDH2
25 intrahepatic cholangiocarcinoma 10.0 IDH1 IDH2
26 blastomycosis 10.0
27 oligodendroglioma 9.9 IDH1 IDH2
28 purpura 9.9
29 neuronitis 9.9
30 ring chromosome y syndrome 9.9
31 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
32 lymphedema 9.8
33 hereditary wilms' tumor 9.8
34 thyroiditis 9.8
35 periostitis 9.8
36 epithelioid hemangioendothelioma 9.8
37 hypertension, essential 9.7
38 insulin-like growth factor i 9.7
39 asthma 9.7
40 hypercholesterolemia, autosomal dominant, 3 9.7
41 hepatitis c virus 9.7
42 gastric cancer 9.7
43 hepatitis 9.7
44 malignant glioma 9.7
45 fusariosis 9.7
46 congenital hypothyroidism 9.7
47 prostatic hypertrophy 9.7
48 tinea cruris 9.7
49 tinea corporis 9.7
50 paracoccidioidomycosis 9.7

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Anatomical Context for Spindle Cell Hemangioma

MalaCards organs/tissues related to Spindle Cell Hemangioma:

38
Cervix, Thyroid, Bone

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show all 23)
# Title Authors Year
1
Spindle Cell Hemangioma of the Midfoot: A Case Report. ( 29242801 )
2017
2
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. ( 26945705 )
2016
3
Intramedullary spindle cell hemangioma: case report. ( 27058496 )
2016
4
Multifocal spindle cell hemangioma: Report of two cases. ( 26728826 )
2016
5
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. ( 26980977 )
2015
6
Spindle cell hemangioma of thyroid. ( 26905134 )
2015
7
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. ( 24673328 )
2014
8
Periosteal spindle cell hemangioma of the fibula: a case report. ( 23525489 )
2013
9
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. ( 23485734 )
2013
10
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. ( 23506121 )
2013
11
Spindle cell hemangioma reoccurrence in the hand: case report. ( 23730241 )
2012
12
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. ( 22927295 )
2012
13
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. ( 22534243 )
2012
14
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. ( 22057234 )
2011
15
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. ( 20860749 )
2010
16
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. ( 17656123 )
2008
17
Spindle cell hemangioma: report of a case presenting in the oral cavity. ( 17880587 )
2007
18
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. ( 16778491 )
2006
19
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? ( 16630186 )
2006
20
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. ( 15860919 )
2005
21
Spindle cell hemangioma. ( 12859394 )
2003
22
Spindle cell hemangioma. ( 10592415 )
1999
23
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. ( 10223237 )
1999

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 IDH1 IDH2
2
Show member pathways
9.74 IDH1 IDH2

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
3 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
4 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Spindle Cell Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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