SCH
MCID: SPN012
MIFTS: 30

Spindle Cell Hemangioma (SCH) malady

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Spindle Cell Hemangioma

Aliases & Descriptions for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 12 56 14 69
Spindle Cell Hemangioendothelioma [dup] 12
Spindle Cell Hemangioendothelioma 56
Spindle Cell Angioendothelioma 12
Sch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:496
NCIt 47 C4754
Orphanet 56 ORPHA210584
UMLS via Orphanet 70 C1304508
ICD10 via Orphanet 34 D18.0
UMLS 69 C1304508

Summaries for Spindle Cell Hemangioma

MalaCards based summary : Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma [dup], is related to hemangioendothelioma and hemangioma. An important gene associated with Spindle Cell Hemangioma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are Peroxisome and Cytosine methylation. Affiliated tissues include bone, thyroid and cervix.

Wikipedia : 71 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Related Diseases for Spindle Cell Hemangioma

Diseases related to Spindle Cell Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 11.3
2 hemangioma 10.4
3 optic disk drusen 10.2 IDH1 IDH2
4 enterovesical fistula 10.2 IDH1 IDH2
5 acrocallosal syndrome 10.2 IDH1 IDH2
6 neurilemmoma 10.2 IDH1 IDH2
7 testis refractory cancer 10.2 IDH1 IDH2
8 cystinosis, nephropathic 10.2 IDH1 IDH2
9 small cell osteogenic sarcoma 10.2 IDH1 IDH2
10 glycogen storage disease type 0 10.2 IDH1 IDH2
11 angioma hereditary neurocutaneous 10.2 IDH1 IDH2
12 neuropathy, ataxia, and retinitis pigmentosa 10.2 IDH1 IDH2
13 breast papillomatosis 10.2 IDH1 IDH2
14 spinal cord astrocytoma 10.2 IDH1 IDH2
15 cystic lymphangioma 10.2 IDH1 IDH2
16 agammaglobulinemia 8, autosomal dominant 10.2 IDH1 IDH2
17 gummatous syphilis 10.2 IDH1 IDH2
18 amyloid tumor 10.2 IDH1 IDH2
19 t-cell adult acute lymphocytic leukemia 10.2 IDH1 IDH2
20 allergic hypersensitivity disease 10.1 IDH1 IDH2
21 vascular cancer 10.1 IDH1 IDH2
22 asynchronous multifocal osteogenic sarcoma 10.1 IDH1 IDH2
23 systemic lupus erythematosus 2 10.1 IDH1 IDH2
24 macrosomia with microphthalmia, lethal 10.1 IDH1 IDH2
25 basophilic carcinoma 10.0 IDH1 IDH2
26 blastomycosis 9.9
27 purpura 9.7
28 neuronitis 9.7
29 lymphedema 9.7
30 thyroiditis 9.7
31 periostitis 9.7
32 enchondroma 9.7
33 epithelioid hemangioendothelioma 9.7
34 hepatitis c virus 9.6
35 insulin-like growth factor i 9.6
36 gastric cancer 9.6
37 hepatitis 9.6
38 malignant glioma 9.6
39 fusariosis 9.6
40 congenital hypothyroidism 9.6
41 prostatic hypertrophy 9.6
42 tinea cruris 9.6
43 tinea corporis 9.6
44 paracoccidioidomycosis 9.6
45 coccidioidomycosis 9.6
46 phaeohyphomycosis 9.6
47 hypothyroidism 9.6
48 prostatitis 9.6
49 hepatitis c 9.6
50 giant cell tumor 9.6

Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to Spindle Cell Hemangioma

Symptoms & Phenotypes for Spindle Cell Hemangioma

Drugs & Therapeutics for Spindle Cell Hemangioma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

Anatomical Context for Spindle Cell Hemangioma

MalaCards organs/tissues related to Spindle Cell Hemangioma:

39
Bone, Thyroid, Cervix

Publications for Spindle Cell Hemangioma

Articles related to Spindle Cell Hemangioma:

(show all 22)
id Title Authors Year
1
Intramedullary spindle cell hemangioma: case report. ( 27058496 )
2016
2
Spindle cell hemangioma in an elderly patient: Uncommon benign vascular neoplasm. ( 26945705 )
2016
3
Multifocal spindle cell hemangioma: Report of two cases. ( 26728826 )
2016
4
Spindle cell hemangioma: Unusual presentation of an uncommon tumor. ( 26980977 )
2015
5
Spindle cell hemangioma of thyroid. ( 26905134 )
2015
6
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. ( 24673328 )
2014
7
Maffucci syndrome with the spindle cell hemangiomas in the mucosa of the lower lip: a rare case report and literature review. ( 23506121 )
2013
8
Periosteal spindle cell hemangioma of the fibula: a case report. ( 23525489 )
2013
9
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. ( 23485734 )
2013
10
Spindle cell hemangioma reoccurrence in the hand: case report. ( 23730241 )
2012
11
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. ( 22534243 )
2012
12
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. ( 22927295 )
2012
13
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. ( 22057234 )
2011
14
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. ( 20860749 )
2010
15
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. ( 17656123 )
2008
16
Spindle cell hemangioma: report of a case presenting in the oral cavity. ( 17880587 )
2007
17
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? ( 16630186 )
2006
18
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. ( 16778491 )
2006
19
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. ( 15860919 )
2005
20
Spindle cell hemangioma. ( 12859394 )
2003
21
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. ( 10223237 )
1999
22
Spindle cell hemangioma. ( 10592415 )
1999

Variations for Spindle Cell Hemangioma

Expression for Spindle Cell Hemangioma

Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for Spindle Cell Hemangioma

Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.87 IDH1 IDH2
2
Show member pathways
9.74 IDH1 IDH2

GO Terms for Spindle Cell Hemangioma

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of cellular response to heat GO:1900034 9.32 BAG1 BAG2
2 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
3 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
4 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
5 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.32 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH1 IDH2
3 adenyl-nucleotide exchange factor activity GO:0000774 9.16 BAG1 BAG2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Spindle Cell Hemangioma

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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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