MCID: SPN012
MIFTS: 33

Spindle Cell Hemangioma malady

Cardiovascular diseases, Fetal diseases, Rare diseases categories

Aliases & Classifications for Spindle Cell Hemangioma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 61UMLS, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Spindle Cell Hemangioma:

Name: Spindle Cell Hemangioma 8 10 48 61
Spindle Cell Hemangioendothelioma 8 48
 
Spindle Cell Angioendothelioma 8
Sch 8


Classifications:



External Ids:

Disease Ontology8 DOID:496
NCIt39 C4754
Orphanet48 210584
ICD10 via Orphanet26 D18.0
UMLS via Orphanet62 C1304508

Summaries for Spindle Cell Hemangioma

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Wikipedia:64 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

MalaCards based summary: Spindle Cell Hemangioma, also known as spindle cell hemangioendothelioma, is related to hemangioma and hemangioendothelioma. An important gene associated with Spindle Cell Hemangioma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Peroxisome and Citric acid cycle (TCA cycle). The compounds Oxalosuccinic acid and Isocitric acid have been mentioned in the context of this disorder. Affiliated tissues include bone and cervix.

Related Diseases for Spindle Cell Hemangioma

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Graphical network of the top 20 diseases related to Spindle Cell Hemangioma:



Diseases related to spindle cell hemangioma

Symptoms for Spindle Cell Hemangioma

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Drugs & Therapeutics for Spindle Cell Hemangioma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Hemangioma

Search NIH Clinical Center for Spindle Cell Hemangioma

Genetic Tests for Spindle Cell Hemangioma

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Anatomical Context for Spindle Cell Hemangioma

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MalaCards organs/tissues related to Spindle Cell Hemangioma:

31
Bone, Cervix

Animal Models for Spindle Cell Hemangioma or affiliated genes

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Publications for Spindle Cell Hemangioma

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Articles related to Spindle Cell Hemangioma:

(show all 16)
idTitleAuthorsYear
1
Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. (24673328)
2014
2
R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. (23485734)
2013
3
Periosteal spindle cell hemangioma of the fibula: a case report. (23525489)
2013
4
Spindle-cell hemangioma (spindle-cell hemangioendothelioma): a diagnosis on fine-needle aspiration cytology. (22927295)
2012
5
Spindle cell hemangioma reoccurrence in the hand: case report. (23730241)
2012
6
Intraosseous spindle cell hemangioma of the calcaneus: a case report and review of the literature. (22534243)
2012
7
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. (22057234)
2011
8
Spindle cell hemangioma of the calf with myxoid stroma and pseudolipoblasts. (20860749)
2010
9
Spindle cell hemangioma (hemangioendothelioma) of the head and neck: case report of an unusual (or underdiagnosed) tumor. (17656123)
2008
10
Spindle cell hemangioma: report of a case presenting in the oral cavity. (17880587)
2007
11
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
12
Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor? (16630186)
2006
13
Huge spindle cell hemangioma of the cervix--mimicking a pelvic tumor. (15860919)
2005
14
Spindle cell hemangioma. (12859394)
2003
15
Hemorrhagic epithelioid and spindle cell hemangioma: a newly recognized, unique vascular tumor of bone. (10223237)
1999
16
Spindle cell hemangioma. (10592415)
1999

Variations for Spindle Cell Hemangioma

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Expression for genes affiliated with Spindle Cell Hemangioma

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Search GEO for disease gene expression data for Spindle Cell Hemangioma.

Pathways for genes affiliated with Spindle Cell Hemangioma

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Pathways related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IDH1, IDH2
2
Show member pathways
TCA cycle36
pyruvate decarboxylation to acetyl CoA36
NAD phosphorylation and dephosphorylation36
TCA Cycle36
conversion of glucose to acetyl CoA and entry into the TCA cycle36
9.9IDH1, IDH2
3
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism59
Glutathione metabolism36
9.9IDH1, IDH2
4
Show member pathways
Alzheimers Disease36
9.0ATP5G1, ATP5G2, ATP5G3
5
Show member pathways
8.7IDH2, ATP5G1, ATP5G2, ATP5G3
6
Show member pathways
8.4ATP5G3, ATP5G2, ATP5G1, IDH2, IDH1

Compounds for genes affiliated with Spindle Cell Hemangioma

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Sources:
24HMDB, 11DrugBank, 44Novoseek
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Compounds related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid249.9IDH1, IDH2
2Isocitric acid24 1110.9IDH1, IDH2
3carbon dioxide44 2410.9IDH1, IDH2
4isocitrate449.8IDH2, IDH1
5Oxoglutaric acid249.6IDH1, IDH2

GO Terms for genes affiliated with Spindle Cell Hemangioma

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Cellular components related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00057399.1IDH1, IDH2, BNIP1, ATP5G1
2proton-transporting ATP synthase complex, coupling factor F(o)GO:00452638.9ATP5G1, ATP5G2, ATP5G3
3mitochondrial proton-transporting ATP synthase complexGO:00057538.7ATP5G3, ATP5G2, ATP5G1

Biological processes related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:00060979.9IDH1, IDH2
2isocitrate metabolic processGO:00061029.9IDH2, IDH1
3tricarboxylic acid cycleGO:00060999.9IDH1, IDH2
42-oxoglutarate metabolic processGO:00061039.6IDH1, IDH2
5ATP synthesis coupled proton transportGO:00159869.2ATP5G2, ATP5G3
6ATP hydrolysis coupled proton transportGO:00159919.1ATP5G1, ATP5G2, ATP5G3

Molecular functions related to Spindle Cell Hemangioma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1isocitrate dehydrogenase (NADP+) activityGO:000445010.0IDH1, IDH2
2NAD bindingGO:00512879.6IDH1, IDH2
3chaperone bindingGO:00510879.3BAG1, BAG2
4magnesium ion bindingGO:00002879.2IDH1, IDH2, TESC
5hydrogen ion transmembrane transporter activityGO:00150789.1ATP5G1, ATP5G2, ATP5G3
6lipid bindingGO:00082899.1ATP5G1, ATP5G2, ATP5G3
7transporter activityGO:00052159.0ATP5G3, ATP5G2, ATP5G1

Sources for Spindle Cell Hemangioma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet