MCID: SPN006
MIFTS: 47

Spindle Cell Lipoma malady

Cancer diseases category

Summaries for Spindle Cell Lipoma

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Disease Ontology:9 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards based summary: Spindle Cell Lipoma is related to lipoma and dermatofibrosarcoma protuberans. An important gene associated with Spindle Cell Lipoma is DES (desmin), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:64 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Aliases & Classifications for Spindle Cell Lipoma

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Spindle Cell Lipoma, Aliases & Descriptions:

Name: Spindle Cell Lipoma 9 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:10184
SNOMED-CT56 404058008, 27313007
NCIt39 C4254

Related Diseases for Spindle Cell Lipoma

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Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1lipoma31.4DES, S100A1, MDM2, CDK4, CD34
2dermatofibrosarcoma protuberans31.1MDM2
3adenoma29.9ACTC1, S100A1, RB1, CDK4
4fibroma29.9DES, VIM, ACTC1, S100A1, CD34
5pleomorphic adenoma29.9DES, VIM, ACTC1, S100A1, MDM2
6fibrosarcoma29.7DES, VIM, ACTC1, MDM2, CD34
7liposarcoma29.5DES, VIM, RB1, MDM2, CDK4, CD34
8peripheral primitive neuroectodermal tumor10.5CD99
9syringoma10.5S100A1
10infantile myofibromatosis10.5DES
11cerebral primitive neuroectodermal tumor10.5CD99
12fasciitis10.5ACTC1
13fibrous histiocytoma10.5CD34
14solitary fibrous tumor10.4
15neurilemmoma10.4CD34
16giant cell glioblastoma10.4MDM2
17adenomatoid tumor10.4VIM
18atypical lipomatous tumor10.3
19desmoid tumor10.3ACTC1, DES
20adenosarcoma10.3ACTC1, DES
21mesenchymal chondrosarcoma10.3VIM, DES
22mucoepidermoid carcinoma10.3S100A1, ACTC1
23alveolar soft part sarcoma10.3DES, VIM
24sertoli cell tumor10.3VIM, DES
25teratoma10.3CD99, ACTC1
26pyogenic granuloma10.2ACTC1, CD34
27lymphangioma10.2CD34, ACTC1
28synovial sarcoma10.2CD99, CD34
29sex cord-gonadal stromal tumor10.2VIM, DES
30uterine sarcoma10.2MDM2, DES
31uterine fibroid10.2DES, S100A1
32oxyphilic adenoma10.2S100A1, VIM
33myositis ossificans10.2
34spindle cell liposarcoma10.2
35pleomorphic lipoma10.2
36cervicitis10.2
37myositis10.2
38calcified aponeurotic fibroma10.2
39myxoid liposarcoma10.2MDM2, CDK4
40epithelioid sarcoma10.2CD34, VIM
41perineurioma10.2VIM, CD34
42renal clear cell carcinoma10.2VIM, S100A1
43noonan syndrome10.2S100A1, ACTC1, DES
44anaplastic oligodendroglioma10.2MDM2, CDK4
45granular cell tumor10.1DES, VIM, S100A1
46embryonal rhabdomyosarcoma10.1DES, ACTC1, CDK4
47chordoma10.1DES, VIM, S100A1
48myoepithelioma10.1VIM, ACTC1, S100A1
49epithelioid leiomyosarcoma10.1DES, VIM, ACTC1
50salivary gland adenoid cystic carcinoma10.1S100A1, ACTC1, VIM

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to spindle cell lipoma

Symptoms for Spindle Cell Lipoma

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Drugs & Therapeutics for Spindle Cell Lipoma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Lipoma

Search NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

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Anatomical Context for Spindle Cell Lipoma

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MalaCards organs/tissues related to Spindle Cell Lipoma:

32
Breast, Tongue, Bone, Skin

Animal Models for Spindle Cell Lipoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Lipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7RB1, MDM2, CDK4, CD34
2MP:00053978.2CD34, CDK4, MDM2, RB1, VIM
3MP:00053847.9VIM, ACTC1, RB1, MDM2, CDK4, CD34
4MP:00053767.8DES, VIM, ACTC1, RB1, CDK4, CD34
5MP:00107687.7DES, VIM, ACTC1, RB1, MDM2, CDK4
6MP:00053867.7DES, VIM, S100A1, RB1, MDM2, CDK4
7MP:00053697.4CDK4, DES, VIM, ACTC1, S100A1, RB1
8MP:00053857.4DES, VIM, ACTC1, S100A1, RB1, MDM2

Publications for Spindle Cell Lipoma

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Articles related to Spindle Cell Lipoma:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
MR imaging features of spindle cell lipoma. (24240205)
2014
2
Spindle Cell Lipoma of the Orbit. (24819207)
2014
3
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
4
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
5
Spindle cell lipoma of the larynx. (23780614)
2013
6
Spindle cell lipoma: a rare tumor of the mediastinum. (23991327)
2013
7
Spindle cell lipoma: a case report and review of literature. (23132485)
2012
8
Focal breast uptake of 99mTc-sestamibi in a man with spindle cell lipoma. (22415820)
2012
9
Spindle cell lipoma with collagen rosettes. (21645033)
2011
10
Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. (20852591)
2011
11
An unusual and spectacular case of spindle cell lipoma of the posterior neck invading the spinal cervical canal and posterior cranial fossa. (21819187)
2011
12
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
13
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (20559119)
2010
14
Left supraclavicular spindle cell lipoma. (20508829)
2010
15
Spindle cell lipoma of the aortic valve: a rare cardiac finding. (19010061)
2010
16
Infantile fibrosarcoma successfully treated with chemotherapy, with occurrence of calcifying aponeurotic fibroma and pleomorphic/spindled celled lipoma at the site 12 years later. (19648795)
2009
17
Infiltrating intramuscular spindle cell lipoma of the face. (19187113)
2009
18
Spindle-cell lipoma. (19623524)
2009
19
Spindle cell lipoma breast. (18603691)
2008
20
Spindle cell lipoma of the spermatic cord. (17956535)
2007
21
CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking. (17497167)
2007
22
Giant spindle cell lipoma of the posterior neck. (17903161)
2007
23
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
24
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
25
Synchronous ordinary lipoma and spindle-cell lipoma diagnosed by fine needle aspiration. (16680778)
2006
26
Spindle cell lipoma of the oral cavity. (16456321)
2006
27
Spindle cell lipoma showing biphasic pattern--a case report. (16075897)
2005
28
Spindle cell lipoma of the floor of the mouth: report of a case. (15917181)
2005
29
Pseudoangiomatous spindle cell lipoma with "true" angiomatous features. (16012844)
2005
30
Spindle cell lipoma of the knee: a case report. (14767709)
2004
31
Dermal spindle cell lipoma of the posterior neck: CT and MR findings. (15018196)
2003
32
Imaging characteristics of spindle cell lipoma. (14573414)
2003
33
Intramuscular dendritic fibromyxolipoma: myxoid variant of spindle cell lipoma? (12675771)
2003
34
Spindle cell lipoma of the hypopharynx. (11453572)
2001
35
Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations. (11748578)
2001
36
Spindle-cell lipoma of the cheek: a case report. (10964060)
2000
37
Pleomorphic lipoma with pseudopapillary structures: a pleomorphic counterpart of pseudoangiomatous spindle cell lipoma. (10792493)
2000
38
Fine-needle aspiration diagnosis of spindle-cell lipoma: a case report and review of the literature. (11074636)
2000
39
Myofibroblastoma of the breast: genetic link with spindle cell lipoma. (10878550)
2000
40
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
41
Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. (9422311)
1998
42
Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. (9199640)
1997
43
Spindle cell lipoma--a pseudoangiomatous variant. (8063285)
1994
44
Spindle cell lipoma within the larynx: a case report with correlated light and electron microscopy. (8321547)
1993
45
Spindle cell lipoma of the breast: a case report and literature review. (8261850)
1993
46
Spindle-cell lipoma: an unusual oral presentation. (2512544)
1989
47
Large intramuscular spindle-cell lipoma. With review of the literature. A case report. (3285867)
1988
48
Spindle cell lipoma. (6487132)
1984
49
Spindle-cell lipoma. A clinical, light- and electron-microscopical study. (7282993)
1981
50
Spindle cell lipoma (report of 2 cases and differential diagnosis). (205204)
1977

Variations for Spindle Cell Lipoma

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Expression for genes affiliated with Spindle Cell Lipoma

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Expression patterns in normal tissues for genes affiliated with Spindle Cell Lipoma

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Pathways for genes affiliated with Spindle Cell Lipoma

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Pathways related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MDM2, CDK4
29.7CDK4, MDM2
39.6RB1, CDK4
49.6CDK4, RB1
5
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.6DES, VIM
69.6MDM2, RB1
79.6MDM2, RB1
89.3DES, VIM, ACTC1
9
Show member pathways
9.3DES, VIM, ACTC1
109.2RB1, MDM2, CDK4
11
Show member pathways
Signaling Pathways in Glioblastoma37
9.2RB1, MDM2, CDK4
12
Show member pathways
9.2RB1, MDM2, CDK4
13
Show member pathways
9.2RB1, MDM2, CDK4
14
Show member pathways
DNA damage response37
9.2RB1, MDM2, CDK4
159.2RB1, MDM2, CDK4
16
Show member pathways
Cell cycle37
9.2RB1, MDM2, CDK4
17
Show member pathways
9.2CDK4, MDM2, RB1
189.2CDK4, MDM2, RB1
19
Show member pathways
9.2CDK4, MDM2, RB1
20
Show member pathways
9.2CDK4, MDM2, RB1
219.2CDK4, MDM2, RB1
229.2CDK4, MDM2, RB1
23
Show member pathways
9.2CDK4, MDM2, RB1
24
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.2CDK4, MDM2, RB1
259.2CDK4, MDM2, RB1
269.1CDK4, RB1, VIM
279.1MDM2, RB1, VIM
28
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I59
8.7CDK4, MDM2, RB1, VIM
29
Show member pathways
8.4DES, VIM, RB1, MDM2, CDK4

Compounds for genes affiliated with Spindle Cell Lipoma

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Compounds related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1orcein449.7ACTC1, VIM, DES
2s 100449.7ACTC1, VIM, DES
3benzo(a)pyrene449.5CDK4, MDM2, RB1
4flavopiridol44 1210.5RB1, MDM2, CDK4
5procollagen449.5ACTC1, VIM, DES
6n-(4-hydroxyphenyl)retinamide449.4VIM, RB1, CDK4
7gefitinib44 50 1211.3CDK4, MDM2, VIM
8adpribose449.3DES, RB1, MDM2, CDK4
9progestin449.3DES, VIM, CDK4
10reticulin449.2CD34, ACTC1, VIM, DES
11toluidine449.2S100A1, VIM, DES
122-methoxyethanol449.2S100A1, ACTC1, VIM
13formaldehyde44 2510.2RB1, ACTC1, VIM, DES
14bromodeoxyuridine449.2CDK4, RB1, VIM, DES
15carboplatin44 50 1211.1CDK4, MDM2, RB1
16roscovitine449.1VIM, RB1, MDM2, CDK4
17adriamycin449.1DES, VIM, RB1, MDM2
18actomyosin449.1VIM, ACTC1, S100A1
19thymidylate449.1CDK4, MDM2, RB1, VIM
20actinomycin d449.0DES, VIM, RB1, MDM2
21paclitaxel44 50 1211.0CDK4, MDM2, RB1, VIM
22rapamycin449.0CDK4, MDM2, RB1, VIM
23silver448.9DES, S100A1, CD34
24mucicarmine448.9DES, VIM, ACTC1, S100A1
25b 723448.9DES, VIM, ACTC1, S100A1
26steroid448.9CDK4, MDM2, RB1, ACTC1, DES
27doxorubicin44 50 1210.8DES, VIM, RB1, MDM2, CDK4
28genistein44 29 60 3 25 1213.8CDK4, MDM2, RB1, VIM
29estradiol44 25 1210.8DES, VIM, RB1, MDM2, CDK4
30lysine448.8MDM2, RB1, VIM, DES
31oxygen44 259.7DES, ACTC1, RB1, MDM2, CDK4
32thymidine44 259.7DES, RB1, MDM2, CDK4, CD34
33cyclic amp44 259.7DES, VIM, RB1, MDM2, CDK4
3412-o-tetradecanoylphorbol 13-acetate448.7DES, VIM, RB1, CDK4, CD34
35dexamethasone44 50 29 1211.7VIM, ACTC1, RB1, MDM2, CDK4
36agar448.6VIM, RB1, MDM2, CDK4, CD34
37proline448.6DES, VIM, MDM2, CDK4
38testosterone44 60 25 1211.5DES, VIM, ACTC1, RB1, MDM2, CDK4
39biotin44 25 1210.4DES, VIM, ACTC1, S100A1, RB1
40hematoxylin448.4DES, VIM, ACTC1, S100A1, CD34
41nitric oxide44 25 1210.4DES, S100A1, RB1, MDM2, CDK4
42glycogen44 259.1DES, VIM, ACTC1, S100A1, MDM2, CDK4
43iron44 259.1DES, VIM, ACTC1, S100A1, MDM2, CDK4
44cysteine447.9DES, VIM, S100A1, RB1, MDM2, CDK4
45tyrosine447.6DES, ACTC1, S100A1, RB1, MDM2, CDK4
46retinoic acid44 258.5DES, VIM, ACTC1, S100A1, RB1, CDK4
47vegf447.4DES, VIM, ACTC1, RB1, MDM2, CD99
48progesterone44 29 60 25 1211.2DES, VIM, ACTC1, S100A1, RB1, MDM2
49estrogen447.1DES, VIM, ACTC1, S100A1, RB1, MDM2
50paraffin446.5CD34, DES, VIM, ACTC1, S100A1, RB1

GO Terms for genes affiliated with Spindle Cell Lipoma

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Cellular components related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.6CDK4, RB1
2cytosolGO:0058298.2CDK4, MDM2, ACTC1, VIM, DES

Biological processes related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:0711579.6CDK4, MDM2
2response to drugGO:0424939.3CDK4, MDM2, ACTC1
3muscle filament slidingGO:0300499.3ACTC1, VIM, DES
4regulation of heart contractionGO:0080169.0DES, S100A1

Molecular functions related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5MDM2, VIM
2identical protein bindingGO:0428027.6MDM2, RB1, S100A1, VIM, DES

Products for genes affiliated with Spindle Cell Lipoma

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Sources for Spindle Cell Lipoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet