MCID: SPN006
MIFTS: 47

Spindle Cell Lipoma malady

Cancer diseases category
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Summaries for Spindle Cell Lipoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards: Spindle Cell Lipoma is related to lipoma and dermatofibrosarcoma. An important gene associated with Spindle Cell Lipoma is DES (desmin), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:65 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Aliases & Classifications for Spindle Cell Lipoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

spindle cell lipoma 8 62


External Ids:

Disease Ontology8 DOID:10184
SNOMED-CT58 27313007, 404058008
NCIt40 C4254

Related Diseases for Spindle Cell Lipoma

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17GeneCards, 18GeneDecks
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Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1lipoma31.7CD34, S100A1, MDM2, DES, CDK4
2dermatofibrosarcoma30.6MDM2
3dermatofibrosarcoma protuberans30.4CD34, DES, S100A1, ACTC1, VIM
4liposarcoma30.4CD34, MDM2, RB1, VIM, DES, CDK4
5adenoma30.2S100A1, ACTC1, CDK4, RB1
6fibroma30.2DES, CD34, S100A1, ACTC1, VIM
7pleomorphic adenoma30.2DES, MDM2, S100A1, ACTC1, VIM
8fibrosarcoma30.1MDM2, VIM, ACTC1, DES, CD34
9pleomorphic lipoma10.3
10atypical lipomatous tumor10.3
11solitary fibrous tumor10.3
12myositis ossificans10.2
13spindle cell liposarcoma10.2
14cervicitis10.2
15myositis10.2
16dysphagia10.2
17calcified aponeurotic fibroma10.2
18peripheral primitive neuroectodermal tumor10.1CD99
19syringoma10.1S100A1
20infantile myofibromatosis10.1DES
21cerebral primitive neuroectodermal tumor10.1CD99
22fasciitis10.1ACTC1
23fibrous histiocytoma10.1CD34
24neurilemmoma10.1CD34
25giant cell glioblastoma10.1MDM2
26adenomatoid tumor10.1VIM
27desmoid tumor10.1ACTC1, DES
28adenosarcoma10.1ACTC1, DES
29mesenchymal chondrosarcoma10.1VIM, DES
30mucoepidermoid carcinoma10.1S100A1, ACTC1
31alveolar soft part sarcoma10.1DES, VIM
32sertoli cell tumor10.1VIM, DES
33teratoma10.1CD99, ACTC1
34pyogenic granuloma10.1ACTC1, CD34
35lymphangioma10.1ACTC1, CD34
36synovial sarcoma10.1CD99, CD34
37sex cord-gonadal stromal tumor10.1DES, VIM
38uterine sarcoma10.1MDM2, DES
39uterine fibroid10.0S100A1, DES
40oxyphilic adenoma10.0VIM, S100A1
41epithelioid sarcoma10.0VIM, CD34
42myxoid liposarcoma10.0MDM2, CDK4
43renal clear cell carcinoma10.0VIM, S100A1
44perineurioma10.0CD34, VIM
45noonan syndrome10.0ACTC1, S100A1, DES
46anaplastic oligodendroglioma10.0MDM2, CDK4
47granular cell tumor10.0S100A1, VIM, DES
48embryonal rhabdomyosarcoma10.0DES, CDK4, ACTC1
49chordoma10.0DES, VIM, S100A1
50myoepithelioma10.0S100A1, VIM, ACTC1

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to spindle cell lipoma

Symptoms for Spindle Cell Lipoma

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Drugs & Therapeutics for Spindle Cell Lipoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Lipoma

Search NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

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Anatomical Context for Spindle Cell Lipoma

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33MalaCards
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MalaCards organs/tissues related to Spindle Cell Lipoma:

33
Breast, Tongue, Skin, Bone

Animal Models for Spindle Cell Lipoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Spindle Cell Lipoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CD34, CDK4, MDM2, RB1
2MP:00053978.2VIM, MDM2, CDK4, CD34, RB1
3MP:00053847.9VIM, CD34, CDK4, MDM2, RB1, ACTC1
4MP:00053767.8VIM, CD34, CDK4, RB1, ACTC1, DES
5MP:00107687.7CDK4, VIM, MDM2, RB1, ACTC1, DES
6MP:00053867.7MDM2, VIM, DES, CDK4, S100A1, RB1
7MP:00053697.4ACTC1, S100A1, DES, VIM, CDK4, MDM2
8MP:00053857.4VIM, ACTC1, S100A1, RB1, MDM2, CDK4

Publications for Spindle Cell Lipoma

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52PubMed
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Articles related to Spindle Cell Lipoma:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
MR imaging features of spindle cell lipoma. (24240205)
2014
2
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
3
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
4
Spindle cell lipoma of the larynx. (23780614)
2013
5
Spindle cell lipoma: a rare tumor of the mediastinum. (23991327)
2013
6
Dysphagia caused by spindle cell lipoma of hypopharynx: presentation of clinical case and literature review. (23326743)
2012
7
Spindle cell lipoma: a case report and review of literature. (23132485)
2012
8
Focal breast uptake of 99mTc-sestamibi in a man with spindle cell lipoma. (22415820)
2012
9
Spindle cell lipoma with collagen rosettes. (21645033)
2011
10
Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. (20852591)
2011
11
An unusual and spectacular case of spindle cell lipoma of the posterior neck invading the spinal cervical canal and posterior cranial fossa. (21819187)
2011
12
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
13
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (20559119)
2010
14
Left supraclavicular spindle cell lipoma. (20508829)
2010
15
Spindle cell lipoma of the aortic valve: a rare cardiac finding. (19010061)
2010
16
Infantile fibrosarcoma successfully treated with chemotherapy, with occurrence of calcifying aponeurotic fibroma and pleomorphic/spindled celled lipoma at the site 12 years later. (19648795)
2009
17
Infiltrating intramuscular spindle cell lipoma of the face. (19187113)
2009
18
Spindle-cell lipoma. (19623524)
2009
19
Spindle cell lipoma breast. (18603691)
2008
20
Spindle cell lipoma of the spermatic cord. (17956535)
2007
21
CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking. (17497167)
2007
22
Giant spindle cell lipoma of the posterior neck. (17903161)
2007
23
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
24
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
25
Synchronous ordinary lipoma and spindle-cell lipoma diagnosed by fine needle aspiration. (16680778)
2006
26
Spindle cell lipoma of the oral cavity. (16456321)
2006
27
Spindle cell lipoma showing biphasic pattern--a case report. (16075897)
2005
28
Spindle cell lipoma of the floor of the mouth: report of a case. (15917181)
2005
29
Pseudoangiomatous spindle cell lipoma with "true" angiomatous features. (16012844)
2005
30
Spindle cell lipoma of the knee: a case report. (14767709)
2004
31
Dermal spindle cell lipoma of the posterior neck: CT and MR findings. (15018196)
2003
32
Imaging characteristics of spindle cell lipoma. (14573414)
2003
33
Intramuscular dendritic fibromyxolipoma: myxoid variant of spindle cell lipoma? (12675771)
2003
34
Spindle cell lipoma of the hypopharynx. (11453572)
2001
35
Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations. (11748578)
2001
36
Spindle-cell lipoma of the cheek: a case report. (10964060)
2000
37
Pleomorphic lipoma with pseudopapillary structures: a pleomorphic counterpart of pseudoangiomatous spindle cell lipoma. (10792493)
2000
38
Fine-needle aspiration diagnosis of spindle-cell lipoma: a case report and review of the literature. (11074636)
2000
39
Myofibroblastoma of the breast: genetic link with spindle cell lipoma. (10878550)
2000
40
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
41
Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. (9422311)
1998
42
Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. (9199640)
1997
43
Spindle cell lipoma--a pseudoangiomatous variant. (8063285)
1994
44
Spindle cell lipoma within the larynx: a case report with correlated light and electron microscopy. (8321547)
1993
45
Spindle cell lipoma of the breast: a case report and literature review. (8261850)
1993
46
Spindle-cell lipoma: an unusual oral presentation. (2512544)
1989
47
Large intramuscular spindle-cell lipoma. With review of the literature. A case report. (3285867)
1988
48
Spindle cell lipoma. (6487132)
1984
49
Spindle-cell lipoma. A clinical, light- and electron-microscopical study. (7282993)
1981
50
Spindle cell lipoma (report of 2 cases and differential diagnosis). (205204)
1977

Variations for Spindle Cell Lipoma

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Expression for genes affiliated with Spindle Cell Lipoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Lipoma

Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for genes affiliated with Spindle Cell Lipoma

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Sources:
50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 5Cell Signaling Technology, 30KEGG, 57SinoBiological
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Pathways related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MDM2, CDK4
29.7CDK4, MDM2
39.6RB1, CDK4
49.6CDK4, RB1
5
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.6DES, VIM
69.6MDM2, RB1
79.6MDM2, RB1
89.3DES, VIM, ACTC1
9
Show member pathways
9.3DES, VIM, ACTC1
109.2RB1, MDM2, CDK4
11
Show member pathways
Signaling Pathways in Glioblastoma38
9.2RB1, MDM2, CDK4
12
Show member pathways
9.2RB1, MDM2, CDK4
13
Show member pathways
9.2RB1, MDM2, CDK4
14
Show member pathways
DNA damage response38
9.2RB1, MDM2, CDK4
159.2RB1, MDM2, CDK4
16
Show member pathways
Cell cycle38
9.2RB1, MDM2, CDK4
17
Show member pathways
9.2CDK4, MDM2, RB1
189.2CDK4, MDM2, RB1
19
Show member pathways
9.2CDK4, MDM2, RB1
20
Show member pathways
9.2CDK4, MDM2, RB1
219.2CDK4, MDM2, RB1
229.2CDK4, MDM2, RB1
23
Show member pathways
9.2CDK4, MDM2, RB1
24
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2CDK4, MDM2, RB1
259.2CDK4, MDM2, RB1
269.1CDK4, RB1, VIM
279.1MDM2, RB1, VIM
28
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.7CDK4, MDM2, RB1, VIM
29
Show member pathways
8.4DES, VIM, RB1, MDM2, CDK4

Compounds for genes affiliated with Spindle Cell Lipoma

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1orcein459.7DES, ACTC1, VIM
2s 100459.7DES, VIM, ACTC1
3benzo(a)pyrene459.5RB1, CDK4, MDM2
4flavopiridol45 1110.5MDM2, CDK4, RB1
5procollagen459.5VIM, DES, ACTC1
6n-(4-hydroxyphenyl)retinamide459.4CDK4, RB1, VIM
7gefitinib45 51 1111.3CDK4, VIM, MDM2
8adpribose459.3RB1, CDK4, DES, MDM2
9progestin459.3DES, VIM, CDK4
10reticulin459.2ACTC1, VIM, CD34, DES
11toluidine459.2S100A1, VIM, DES
122-methoxyethanol459.2S100A1, ACTC1, VIM
13formaldehyde45 2410.2ACTC1, DES, VIM, RB1
14bromodeoxyuridine459.2DES, VIM, CDK4, RB1
15carboplatin45 51 1111.1CDK4, MDM2, RB1
16roscovitine459.1RB1, MDM2, CDK4, VIM
17adriamycin459.1DES, VIM, RB1, MDM2
18actomyosin459.1ACTC1, VIM, S100A1
19thymidylate459.1CDK4, MDM2, VIM, RB1
20actinomycin d459.0VIM, RB1, DES, MDM2
21paclitaxel45 51 1111.0CDK4, MDM2, RB1, VIM
22rapamycin459.0RB1, MDM2, CDK4, VIM
23silver458.9DES, CD34, S100A1
24mucicarmine458.9VIM, ACTC1, S100A1, DES
25b 723458.9DES, VIM, ACTC1, S100A1
26steroid458.9RB1, ACTC1, CDK4, MDM2, DES
27doxorubicin45 51 1110.8MDM2, RB1, VIM, DES, CDK4
28genistein45 29 61 3 24 1113.8CDK4, MDM2, RB1, VIM
29estradiol45 24 1110.8DES, MDM2, CDK4, RB1, VIM
30lysine458.8MDM2, VIM, DES, RB1
31oxygen45 249.7ACTC1, MDM2, CDK4, DES, RB1
32thymidine45 249.7CD34, DES, RB1, MDM2, CDK4
33cyclic amp45 249.7DES, VIM, RB1, CDK4, MDM2
3412-o-tetradecanoylphorbol 13-acetate458.7VIM, DES, CD34, CDK4, RB1
35dexamethasone45 51 29 1111.7MDM2, RB1, CDK4, ACTC1, VIM
36agar458.6CDK4, VIM, RB1, MDM2, CD34
37proline458.6DES, CDK4, MDM2, VIM
38testosterone45 61 24 1111.5MDM2, RB1, VIM, DES, ACTC1, CDK4
39biotin45 24 1110.4ACTC1, S100A1, DES, VIM, RB1
40hematoxylin458.4ACTC1, DES, S100A1, CD34, VIM
41nitric oxide45 24 1110.4S100A1, DES, RB1, MDM2, CDK4
42glycogen45 249.1ACTC1, MDM2, S100A1, VIM, DES, CDK4
43iron45 249.1MDM2, CDK4, S100A1, DES, VIM, ACTC1
44cysteine457.9DES, VIM, S100A1, RB1, MDM2, CDK4
45tyrosine457.6DES, ACTC1, S100A1, CD34, CDK4, MDM2
46retinoic acid45 248.5CDK4, RB1, ACTC1, DES, VIM, CD34
47vegf457.4CDK4, CD99, MDM2, RB1, ACTC1, VIM
48progesterone45 29 61 24 1111.2DES, VIM, ACTC1, S100A1, RB1, MDM2
49estrogen457.1ACTC1, CD34, RB1, MDM2, CDK4, S100A1
50paraffin456.5CDK4, DES, VIM, ACTC1, S100A1, RB1

GO Terms for genes affiliated with Spindle Cell Lipoma

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16Gene Ontology
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Cellular components related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.6CDK4, RB1
2cytosolGO:0058298.2CDK4, MDM2, ACTC1, VIM, DES

Biological processes related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:0711579.6CDK4, MDM2
2response to drugGO:0424939.3CDK4, MDM2, ACTC1
3muscle filament slidingGO:0300499.3ACTC1, VIM, DES
4regulation of heart contractionGO:0080169.0DES, S100A1

Molecular functions related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.5MDM2, VIM
2identical protein bindingGO:0428027.6MDM2, RB1, S100A1, VIM, DES

Products for genes affiliated with Spindle Cell Lipoma

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Sources for Spindle Cell Lipoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet