MCID: SPN006
MIFTS: 39

Spindle Cell Lipoma malady

Summaries for Spindle Cell Lipoma

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Disease Ontology:9 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards based summary: Spindle Cell Lipoma is related to lipoma and dermatofibrosarcoma protuberans. An important gene associated with Spindle Cell Lipoma is DES (desmin), and among its related pathways are DNA damage ATM ATR regulation of G1 S checkpoint and Oncogene Induced Senescence. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:63 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Aliases & Classifications for Spindle Cell Lipoma

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Spindle Cell Lipoma, Aliases & Descriptions:

Name: Spindle Cell Lipoma 9 60


External Ids:

Disease Ontology9 DOID:10184
SNOMED-CT55 27313007, 404058008
NCIt38 C4254

Related Diseases for Spindle Cell Lipoma

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Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1lipoma31.4DES, S100A1, MDM2, CDK4, CD34
2dermatofibrosarcoma protuberans31.1MDM2
3adenoma29.9ACTC1, S100A1, RB1, CDK4
4fibroma29.9DES, VIM, ACTC1, S100A1, CD34
5pleomorphic adenoma29.8DES, VIM, ACTC1, S100A1, MDM2
6fibrosarcoma29.7DES, VIM, ACTC1, MDM2, CD34
7liposarcoma29.5DES, VIM, RB1, MDM2, CDK4, CD34
8peripheral primitive neuroectodermal tumor10.5CD99
9syringoma10.5S100A1
10infantile myofibromatosis10.5DES
11ewing's family of tumors10.5CD99
12fasciitis10.5ACTC1
13fibrous histiocytoma10.5CD34
14neurilemmoma10.4CD34
15giant cell glioblastoma10.4MDM2
16adenomatoid tumor10.4VIM
17pleomorphic lipoma10.3
18atypical lipomatous tumor10.3
19desmoid disease, hereditary10.3ACTC1, DES
20adenosarcoma10.3ACTC1, DES
21mesenchymal chondrosarcoma10.3VIM, DES
22mucoepidermoid carcinoma10.3S100A1, ACTC1
23alveolar soft-part sarcoma10.3DES, VIM
24sertoli cell tumor10.2VIM, DES
25teratoma10.2CD99, ACTC1
26pyogenic granuloma10.2ACTC1, CD34
27lymphangioma10.2CD34, ACTC1
28sarcoma, synovial10.2CD99, CD34
29sex cord-gonadal stromal tumor10.2VIM, DES
30uterine sarcoma10.2MDM2, DES
31uterine fibroid10.2DES, S100A1
32oxyphilic adenoma10.2S100A1, VIM
33connective tissue benign neoplasm10.2CDK4, MDM2
34myositis ossificans10.2
35spindle cell liposarcoma10.2
36cervicitis10.2
37myositis10.2
38dysphagia10.2
39calcified aponeurotic fibroma10.2
40myxoid liposarcoma10.2MDM2, CDK4
41epithelioid sarcoma10.2CD34, VIM
42perineurioma10.2VIM, CD34
43renal clear cell carcinoma10.2VIM, S100A1
44noonan syndrome 110.2S100A1, ACTC1, DES
45anaplastic oligodendroglioma10.2MDM2, CDK4
46granular cell tumor10.1DES, VIM, S100A1
47embryonal rhabdomyosarcoma10.1DES, ACTC1, CDK4
48chordoma10.1DES, VIM, S100A1
49myoepithelioma10.1VIM, ACTC1, S100A1
50epithelioid leiomyosarcoma10.1DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to spindle cell lipoma

Symptoms for Spindle Cell Lipoma

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Drugs & Therapeutics for Spindle Cell Lipoma

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Drug clinical trials:

Search ClinicalTrials for Spindle Cell Lipoma

Search NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

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Anatomical Context for Spindle Cell Lipoma

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MalaCards organs/tissues related to Spindle Cell Lipoma:

31
Breast, Tongue, Bone, Skin

Animal Models for Spindle Cell Lipoma or affiliated genes

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MGI Mouse Phenotypes related to Spindle Cell Lipoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7RB1, MDM2, CDK4, CD34
2MP:00053978.2CD34, CDK4, MDM2, RB1, VIM
3MP:00053847.9VIM, ACTC1, RB1, MDM2, CDK4, CD34
4MP:00053767.8DES, VIM, ACTC1, RB1, CDK4, CD34
5MP:00107687.7DES, VIM, ACTC1, RB1, MDM2, CDK4
6MP:00053867.7DES, VIM, S100A1, RB1, MDM2, CDK4
7MP:00053697.4CDK4, DES, VIM, ACTC1, S100A1, RB1
8MP:00053857.4DES, VIM, ACTC1, S100A1, RB1, MDM2

Publications for Spindle Cell Lipoma

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Articles related to Spindle Cell Lipoma:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Rare occurrence of lip spindle cell lipoma. (25815220)
2015
2
"Low-Fat" Pseudoangiomatous Spindle Cell Lipoma: A Rare Variant With Loss of 13q14 Region. (25839893)
2015
3
MR imaging features of spindle cell lipoma. (24240205)
2014
4
Spindle Cell Lipoma of the Orbit. (24819207)
2014
5
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
6
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
7
Spindle cell lipoma of the larynx. (23780614)
2013
8
Spindle cell lipoma: a rare tumor of the mediastinum. (23991327)
2013
9
Dysphagia caused by spindle cell lipoma of hypopharynx: presentation of clinical case and literature review. (23326743)
2012
10
Spindle cell lipoma: a case report and review of literature. (23132485)
2012
11
Spindle cell lipoma with collagen rosettes. (21645033)
2011
12
Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. (20852591)
2011
13
An unusual and spectacular case of spindle cell lipoma of the posterior neck invading the spinal cervical canal and posterior cranial fossa. (21819187)
2011
14
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
15
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (20559119)
2010
16
Left supraclavicular spindle cell lipoma. (20508829)
2010
17
Spindle cell lipoma of the aortic valve: a rare cardiac finding. (19010061)
2010
18
Infantile fibrosarcoma successfully treated with chemotherapy, with occurrence of calcifying aponeurotic fibroma and pleomorphic/spindled celled lipoma at the site 12 years later. (19648795)
2009
19
Infiltrating intramuscular spindle cell lipoma of the face. (19187113)
2009
20
Spindle cell lipoma breast. (18603691)
2008
21
Spindle cell lipoma of the spermatic cord. (17956535)
2007
22
CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking. (17497167)
2007
23
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
24
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
25
Synchronous ordinary lipoma and spindle-cell lipoma diagnosed by fine needle aspiration. (16680778)
2006
26
Spindle cell lipoma of the oral cavity. (16456321)
2006
27
Spindle cell lipoma showing biphasic pattern--a case report. (16075897)
2005
28
Spindle cell lipoma of the floor of the mouth: report of a case. (15917181)
2005
29
Pseudoangiomatous spindle cell lipoma with "true" angiomatous features. (16012844)
2005
30
Spindle cell lipoma of the knee: a case report. (14767709)
2004
31
Dermal spindle cell lipoma of the posterior neck: CT and MR findings. (15018196)
2003
32
Imaging characteristics of spindle cell lipoma. (14573414)
2003
33
Intramuscular dendritic fibromyxolipoma: myxoid variant of spindle cell lipoma? (12675771)
2003
34
Spindle cell lipoma of the hypopharynx. (11453572)
2001
35
Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations. (11748578)
2001
36
Spindle-cell lipoma of the cheek: a case report. (10964060)
2000
37
Pleomorphic lipoma with pseudopapillary structures: a pleomorphic counterpart of pseudoangiomatous spindle cell lipoma. (10792493)
2000
38
Fine-needle aspiration diagnosis of spindle-cell lipoma: a case report and review of the literature. (11074636)
2000
39
Myofibroblastoma of the breast: genetic link with spindle cell lipoma. (10878550)
2000
40
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
41
Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. (9422311)
1998
42
Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. (9199640)
1997
43
Spindle cell lipoma--a pseudoangiomatous variant. (8063285)
1994
44
Spindle cell lipoma within the larynx: a case report with correlated light and electron microscopy. (8321547)
1993
45
Spindle cell lipoma of the breast: a case report and literature review. (8261850)
1993
46
Spindle-cell lipoma: an unusual oral presentation. (2512544)
1989
47
Large intramuscular spindle-cell lipoma. With review of the literature. A case report. (3285867)
1988
48
Spindle cell lipoma. (6487132)
1984
49
Spindle-cell lipoma. A clinical, light- and electron-microscopical study. (7282993)
1981
50
Spindle cell lipoma (report of 2 cases and differential diagnosis). (205204)
1977

Variations for Spindle Cell Lipoma

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Expression for genes affiliated with Spindle Cell Lipoma

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Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for genes affiliated with Spindle Cell Lipoma

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Pathways related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MDM2, CDK4
29.7CDK4, MDM2
39.6RB1, CDK4
49.6CDK4, RB1
5
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.6DES, VIM
69.6MDM2, RB1
79.6MDM2, RB1
89.3DES, VIM, ACTC1
9
Show member pathways
9.3DES, VIM, ACTC1
109.2RB1, MDM2, CDK4
11
Show member pathways
Signaling Pathways in Glioblastoma36
9.2RB1, MDM2, CDK4
12
Show member pathways
9.2RB1, MDM2, CDK4
13
Show member pathways
9.2RB1, MDM2, CDK4
14
Show member pathways
DNA damage response36
9.2RB1, MDM2, CDK4
159.2RB1, MDM2, CDK4
16
Show member pathways
Cell cycle36
9.2RB1, MDM2, CDK4
17
Show member pathways
9.2CDK4, MDM2, RB1
189.2CDK4, MDM2, RB1
19
Show member pathways
9.2CDK4, MDM2, RB1
20
Show member pathways
9.2CDK4, MDM2, RB1
219.2CDK4, MDM2, RB1
229.2CDK4, MDM2, RB1
23
Show member pathways
9.2CDK4, MDM2, RB1
24
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2CDK4, MDM2, RB1
259.2CDK4, MDM2, RB1
269.1CDK4, RB1, VIM
279.1MDM2, RB1, VIM
28
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.7CDK4, MDM2, RB1, VIM
29
Show member pathways
8.4DES, VIM, RB1, MDM2, CDK4

Compounds for genes affiliated with Spindle Cell Lipoma

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Compounds related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1orcein439.7DES, ACTC1, VIM
2s 100439.7DES, VIM, ACTC1
3benzo(a)pyrene439.5RB1, CDK4, MDM2
4flavopiridol43 1210.5MDM2, CDK4, RB1
5procollagen439.5VIM, DES, ACTC1
6n-(4-hydroxyphenyl)retinamide439.4CDK4, RB1, VIM
7gefitinib43 49 1211.3CDK4, VIM, MDM2
8adpribose439.3RB1, CDK4, DES, MDM2
9progestin439.3DES, VIM, CDK4
10reticulin439.2ACTC1, VIM, CD34, DES
11toluidine439.2S100A1, VIM, DES
122-methoxyethanol439.2S100A1, ACTC1, VIM
13formaldehyde43 2410.2ACTC1, DES, VIM, RB1
14bromodeoxyuridine439.2DES, VIM, CDK4, RB1
15carboplatin43 49 1211.1CDK4, MDM2, RB1
16roscovitine439.1RB1, MDM2, CDK4, VIM
17adriamycin439.1DES, VIM, RB1, MDM2
18actomyosin439.1ACTC1, VIM, S100A1
19thymidylate439.1CDK4, MDM2, VIM, RB1
20actinomycin d439.0VIM, RB1, DES, MDM2
21paclitaxel43 49 1211.0CDK4, MDM2, RB1, VIM
22rapamycin439.0RB1, MDM2, CDK4, VIM
23silver438.9DES, CD34, S100A1
24mucicarmine438.9VIM, ACTC1, S100A1, DES
25b 723438.9DES, VIM, ACTC1, S100A1
26steroid438.9RB1, ACTC1, CDK4, MDM2, DES
27doxorubicin43 49 1210.8MDM2, RB1, VIM, DES, CDK4
28genistein43 28 59 2 24 1213.8CDK4, MDM2, RB1, VIM
29estradiol43 24 1210.8DES, MDM2, CDK4, RB1, VIM
30lysine438.8MDM2, VIM, DES, RB1
31oxygen43 249.7ACTC1, MDM2, CDK4, DES, RB1
32thymidine43 249.7CD34, DES, RB1, MDM2, CDK4
33cyclic amp43 249.7DES, VIM, RB1, CDK4, MDM2
3412-o-tetradecanoylphorbol 13-acetate438.7VIM, DES, CD34, CDK4, RB1
35dexamethasone43 49 28 1211.7MDM2, RB1, CDK4, ACTC1, VIM
36agar438.6CDK4, VIM, RB1, MDM2, CD34
37proline438.6DES, CDK4, MDM2, VIM
38testosterone43 59 24 1211.5MDM2, RB1, VIM, DES, ACTC1, CDK4
39biotin43 24 1210.4ACTC1, S100A1, DES, VIM, RB1
40hematoxylin438.4ACTC1, DES, S100A1, CD34, VIM
41nitric oxide43 24 1210.4S100A1, DES, RB1, MDM2, CDK4
42glycogen43 249.1ACTC1, MDM2, S100A1, VIM, DES, CDK4
43iron43 249.1MDM2, CDK4, S100A1, DES, VIM, ACTC1
44cysteine437.9DES, VIM, S100A1, RB1, MDM2, CDK4
45tyrosine437.6DES, ACTC1, S100A1, CD34, CDK4, MDM2
46retinoic acid43 248.5CDK4, RB1, ACTC1, DES, VIM, CD34
47vegf437.4CDK4, CD99, MDM2, RB1, ACTC1, VIM
48progesterone43 28 59 24 1211.2DES, VIM, ACTC1, S100A1, RB1, MDM2
49estrogen437.1ACTC1, CD34, RB1, MDM2, CDK4, S100A1
50paraffin436.5CDK4, DES, VIM, ACTC1, S100A1, RB1

GO Terms for genes affiliated with Spindle Cell Lipoma

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Cellular components related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00007859.6CDK4, RB1
2cytosolGO:00058298.2CDK4, MDM2, ACTC1, VIM, DES

Biological processes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:00711579.6CDK4, MDM2
2response to drugGO:00424939.3CDK4, MDM2, ACTC1
3muscle filament slidingGO:00300499.3ACTC1, VIM, DES
4regulation of heart contractionGO:00080169.0DES, S100A1

Molecular functions related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.5MDM2, VIM
2identical protein bindingGO:00428027.6MDM2, RB1, S100A1, VIM, DES

Products for genes affiliated with Spindle Cell Lipoma

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Sources for Spindle Cell Lipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet