MCID: SPN006
MIFTS: 43

Spindle Cell Lipoma malady

Summaries for Spindle Cell Lipoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards: Spindle Cell Lipoma is related to lipoma and liposarcoma. An important gene associated with Spindle Cell Lipoma is DES (desmin), and among its related pathways are Cell Cycle and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds glycogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and bone, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:63 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Aliases & Classifications for Spindle Cell Lipoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

spindle cell lipoma 8 60


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Disease Ontology8 DOID:10184
SNOMED-CT56 404058008, 27313007
NCIt39 C4254

Related Diseases for Spindle Cell Lipoma

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17GeneCards, 18GeneDecks
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Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1lipoma31.7CD34, CDK4, DES, MDM2, S100A1
2liposarcoma30.5CD34, CDK4, DES, RB1, MDM2, VIM
3dermatofibrosarcoma30.4MDM2
4adenoma30.2S100A1, RB1, CDK4, ACTC1
5pleomorphic adenoma30.2VIM, S100A1, MDM2, DES, ACTC1
6fibrosarcoma30.2VIM, MDM2, DES, CD34, ACTC1
7breast lipoma10.6
8pleomorphic lipoma10.4
9spindle cell liposarcoma10.4
10breast myofibroblastoma10.3
11lipoma of spermatic cord10.3
12atypical lipomatous tumor10.3
13infiltrating lipoma10.1
14mediastinum liposarcoma10.1
15myositis ossificans10.1
16skin lipoma10.1
17cervicitis10.1
18myositis10.1
19cerebral primitive neuroectodermal tumor10.0CD99
20peripheral primitive neuroectodermal tumor10.0CD99
21syringoma10.0S100A1
22infantile myofibromatosis10.0DES
23hepatitis10.0CD99
24lymphangioleiomyomatosis10.0DES
25psoriasis10.0S100A1
26hepatitis c10.0CD99
27fasciitis10.0ACTC1
28rheumatoid arthritis10.0S100A1
29paraganglioma10.0S100A1
30gliosarcoma10.0CDK4
31cutaneous fibrous histiocytoma10.0CD34
32malignant fibroxanthoma10.0CD34
33neurilemmoma10.0CD34
34acute leukemia10.0CD34
35oxyphilic adenoma10.0S100A1
36kaposi's sarcoma10.0CD34
37vascular cancer10.0CD34
38myelodysplastic syndromes10.0CD34
39giant cell glioblastoma10.0MDM2
40eye disease10.0MDM2
41epidermolysis bullosa simplex10.0DES
42desmoid tumor10.0DES, ACTC1
43teratoma10.0ACTC1, CD99
44hemangioma10.0ACTC1, CD34
45stomach cancer10.0CD34, CD99
46adenosarcoma10.0DES, ACTC1
47hemangioendothelioma10.0CD34
48pyogenic granuloma10.0CD34, ACTC1
49mucoepidermoid carcinoma10.0S100A1, ACTC1
50anaplastic oligodendroglioma10.0CDK4, MDM2

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to spindle cell lipoma

Clinical Features for Spindle Cell Lipoma

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Drugs & Therapeutics for Spindle Cell Lipoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Spindle Cell Lipoma

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Anatomical Context for Spindle Cell Lipoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Lipoma:

32
Breast, Tongue, Bone, Skin

Animal Models for Spindle Cell Lipoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Lipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9MDM2, RB1, CDK4, ACTC1
2MP:00053868.1VIM, S100A1, MDM2, RB1, CDK4, DES
3MP:00053857.4ACTC1, VIM, S100A1, CDK4, MDM2, DES

Publications for Spindle Cell Lipoma

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50PubMed
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Articles related to Spindle Cell Lipoma:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
MR imaging features of spindle cell lipoma. (24240205)
2014
2
Spindle cell lipoma of the larynx. (23780614)
2013
3
Retropharyngeal spindle cell/pleomorphic lipoma. (23690719)
2013
4
Spindle cell lipoma: a rare tumor of the mediastinum. (23991327)
2013
5
Fine needle aspiration biopsy of intraparotid spindle cell lipoma: a case report. (22021087)
2013
6
Subungual spindle cell lipoma. (22171806)
2013
7
Spindle cell lipoma: a case report and review of literature. (23132485)
2012
8
Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. (22790852)
2012
9
Solitary fibrous tumor: is there a molecular relationship with cellular angiofibroma, spindle cell lipoma, and mammary-type myofibroblastoma? (22586056)
2012
10
Spindle cell lipoma with collagen rosettes. (21645033)
2011
11
An unusual and spectacular case of spindle cell lipoma of the posterior neck invading the spinal cervical canal and posterior cranial fossa. (21819187)
2011
12
Spindle cell lipoma of the anterior triangle of the neck: a rare entity. (21739018)
2011
13
Left supraclavicular spindle cell lipoma. (20508829)
2010
14
Spindle cell lipoma of the aortic valve: a rare cardiac finding. (19010061)
2010
15
Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. (20228779)
2010
16
Suprasellar spindle cell lipoma. (19433296)
2009
17
Spindle cell lipoma in Retzius' space. (19228229)
2009
18
Spindle cell lipoma breast. (18603691)
2008
19
Spindle cell lipoma of the spermatic cord. (17956535)
2007
20
Acute stridor caused by a previously asymptomatic large oropharyngeal spindle cell lipoma. (17433592)
2007
21
Angiomatous spindle cell lipoma: Report of three cases with immunohistochemical and ultrastructural study and reappraisal of former 'pseudoangiomatous' variant. (17199739)
2007
22
Cellular angiofibroma: another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma. (17727484)
2007
23
Spindle cell lipoma in the posterior third of the tongue. (17380840)
2006
24
Left-sided facial mass. Spindle cell lipoma of the parotid gland. (16740044)
2006
25
Spindle cell lipoma of the spermatic cord. (15138540)
2004
26
Desmin expression in spindle cell lipomas: a potential diagnostic pitfall. (15322874)
2004
27
Spindle cell lipoma of the alveolar mucosa: a case report. (11862206)
2002
28
Radiologic-Pathologic Conference of Keller Army Community Hospital at West Point, the United States Military Academy: spindle cell lipoma of the upper back. (12388491)
2002
29
Low cellularity of fine needle aspirates in the evaluation of spindle cell lipoma. (12365205)
2002
30
Spindle cell lipoma of the hypopharynx. (11453572)
2001
31
Fine-needle aspiration diagnosis of spindle-cell lipoma: a case report and review of the literature. (11074636)
2000
32
Intradermal spindle cell/pleomorphic lipoma: a distinct subset. (11190440)
2000
33
Spindle cell lipoma of the foot and the application of CD34 immunohistochemistry to atypical lipomatous tumors in unusual locations. (10981875)
2000
34
Spindle-cell lipoma of the preseptal eyelid. (9612807)
1998
35
Spindle cell lipoma is strongly CD34 positive. An immunohistochemical study. (9001985)
1996
36
Spindle cell lipoma of the breast: a case report and literature review. (8261850)
1993
37
Pathologic quiz case 1. Spindle cell lipoma. (8484949)
1993
38
Case report 751: Spindle cell lipoma causing marked bone erosion. (1523441)
1992
39
Spindle-cell lipoma: an unusual oral presentation. (2512544)
1989
40
Spindle cell and pleomorphic lipoma: an immunohistochemical study and histogenetic analysis. (2769483)
1989
41
Spindle cell lipoma of the orbit. (4050936)
1985
42
Spindle cell lipoma. (6487132)
1984
43
Intraoral spindle cell lipoma: case report with correlated light and electron microscopy. (6582434)
1984
44
Vascular spindle cell lipoma. (7096719)
1982
45
Spindle cell lipoma in a perianal location. (7152511)
1982
46
Spindle-cell lipoma. A clinical, light- and electron-microscopical study. (7282993)
1981
47
Spindle cell lipoma of the orbit. (758889)
1979
48
Spindle cell lipoma. An unusual dermatologic presentation. (686729)
1978
49
Spindle cell lipoma: a benign lipoma variant with potential hazards of diagnostic misinterpretation. (684507)
1978
50
Spindle cell lipoma (report of 2 cases and differential diagnosis). (205204)
1977

Genetic Variations for Spindle Cell Lipoma

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Expression for genes affiliated with Spindle Cell Lipoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Lipoma

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Pathways for genes affiliated with Spindle Cell Lipoma

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 55SinoBiological
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Pathways related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0UBE2D1
29.7RB1, MDM2
3
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9.7RB1, MDM2
49.5UBE2D1, RB1
5
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9.4VIM, DES, ACTC1
69.4ACTC1, DES, VIM
7
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9.3CDK4, RB1, MDM2
8
Transcription P53 signaling pathway
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9.3CDK4, RB1, MDM2
9
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9.3CDK4, RB1, MDM2
10
Hide members
9.3CDK4, RB1, MDM2
11
Hide members
9.3CDK4, RB1, MDM2
12
Hide members
9.3CDK4, RB1, MDM2
139.3MDM2, RB1, CDK4
14
Hide members
9.3MDM2, RB1, CDK4
15
Hide members
9.3MDM2, RB1, CDK4
169.3MDM2, RB1, CDK4
17
Hide members
9.3MDM2, RB1, CDK4
189.3MDM2, RB1, CDK4
199.3CDK4, RB1, VIM
209.2RB1, MDM2, VIM
21
Hide members
8.6VIM, MDM2, RB1, DES, CDK4
22
Hide members
8.4CDK4, RB1, MDM2, UBE2D1, VIM

Compounds for genes affiliated with Spindle Cell Lipoma

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1glycogen44 2410.9MDM2, ACTC1, CDK4
2orcein449.8ACTC1, DES, VIM
3s 100449.8DES, ACTC1, VIM
4benzo(a)pyrene449.7RB1, CDK4, MDM2
5flavopiridol44 1110.7CDK4, MDM2, RB1
6dexamethasone44 49 28 1112.6RB1, CDK4, MDM2
7paclitaxel44 49 1111.6CDK4, RB1, MDM2
8carboplatin44 49 1111.6CDK4, RB1, MDM2
9toluidine449.6VIM, S100A1, DES
10n-(4-hydroxyphenyl)retinamide449.6RB1, CDK4, VIM
112-methoxyethanol449.6S100A1, ACTC1, VIM
12progestin449.6DES, CDK4, VIM
13gefitinib44 49 1111.5CDK4, MDM2, VIM
14actomyosin449.5S100A1, VIM, ACTC1
15adpribose449.4CDK4, RB1, MDM2, DES
16formaldehyde44 2410.4ACTC1, DES, RB1, VIM
17bromodeoxyuridine449.3RB1, VIM, DES, CDK4
18adriamycin449.3MDM2, RB1, VIM, DES
19roscovitine449.3CDK4, VIM, MDM2, RB1
20mucicarmine449.3ACTC1, VIM, DES, S100A1
21b 723449.3ACTC1, S100A1, VIM, DES
22thymidylate449.3VIM, CDK4, RB1, MDM2
23vincristine44 49 1111.2RB1, MDM2, VIM
24rapamycin449.2CDK4, RB1, MDM2, VIM
25p002449.1MDM2, DES, RB1
26actinomycin d449.1DES, RB1, MDM2, VIM
27proline449.1VIM, DES, CDK4, MDM2
28steroid449.0DES, ACTC1, CDK4, MDM2, RB1
29silver449.0CD34, DES, S100A1
30reticulin449.0VIM, DES, CD34, ACTC1
31genistein44 28 59 2 11 2414.0RB1, MDM2, CDK4, VIM
32doxorubicin44 49 1111.0CDK4, VIM, DES, MDM2, RB1
33estradiol44 11 2411.0VIM, DES, RB1, CDK4, MDM2
34lysine448.9DES, RB1, MDM2, VIM
35cyclic amp44 249.9MDM2, CDK4, DES, RB1, VIM
36biotin44 11 2410.9RB1, ACTC1, S100A1, VIM, DES
37nitric oxide44 11 2410.7DES, S100A1, CDK4, MDM2, RB1
38testosterone44 59 11 2411.7MDM2, CDK4, ACTC1, DES, VIM, RB1
39oxygen44 249.6DES, CDK4, MDM2, ACTC1, RB1
40thymidine44 249.6DES, CDK4, RB1, CD34, MDM2
4112-o-tetradecanoylphorbol 13-acetate448.5CD34, VIM, RB1, DES, CDK4
42hematoxylin448.5VIM, S100A1, DES, CD34, ACTC1
43agar448.5CDK4, RB1, VIM, MDM2, CD34
44cysteine448.4S100A1, RB1, DES, CDK4, VIM, MDM2
45iron44 249.1MDM2, S100A1, ACTC1, CDK4, VIM, UBE2D1
46tyrosine447.7ACTC1, S100A1, MDM2, RB1, CDK4, CD34
47retinoic acid44 248.7VIM, S100A1, RB1, CDK4, CD34, DES
48progesterone44 59 28 11 2411.4VIM, DES, ACTC1, CDK4, MDM2, S100A1
49vegf447.3VIM, ACTC1, CD34, CD99, RB1, CDK4
50paraffin446.8CDK4, ACTC1, S100A1, CD34, CD99, DES

GO Terms for genes affiliated with Spindle Cell Lipoma

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16Gene Ontology
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Cellular components related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.2ACTC1, CDK4, DES, MDM2, UBE2D1, VIM

Biological processes related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of heart contractionGO:0080169.7DES, S100A1
2muscle filament slidingGO:0300499.1ACTC1, DES, VIM

Molecular functions related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.6MDM2, VIM
2identical protein bindingGO:0428028.1DES, RB1, MDM2, S100A1, VIM

Products for genes affiliated with Spindle Cell Lipoma

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Sources for Spindle Cell Lipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet