MCID: SPN006
MIFTS: 39

Spindle Cell Lipoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Lipoma

MalaCards integrated aliases for Spindle Cell Lipoma:

Name: Spindle Cell Lipoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10184
NCIt 46 C4254
SNOMED-CT 64 27313007 404058008
UMLS 69 C0334474

Summaries for Spindle Cell Lipoma

Disease Ontology : 12 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards based summary : Spindle Cell Lipoma is related to lipomatosis, multiple and dermatofibrosarcoma protuberans. An important gene associated with Spindle Cell Lipoma is DES (Desmin), and among its related pathways/superpathways are Endometrial cancer and PI3K-Akt signaling pathway. Affiliated tissues include tongue, skin and adipocyte, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Related Diseases for Spindle Cell Lipoma

Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 lipomatosis, multiple 30.8 CDK4 DES MDM2
2 dermatofibrosarcoma protuberans 30.0 ACTC1 DES VIM
3 atypical lipomatous tumor 29.7 CDK4 MDM2
4 pleomorphic adenoma 29.5 ACTC1 MDM2 VIM
5 hemangiopericytoma, malignant 29.5 ACTC1 DES MDM2 VIM
6 spindle cell liposarcoma 29.4 CDK4 MDM2
7 well-differentiated liposarcoma 29.4 CDK4 MDM2
8 pleomorphic lipoma 29.4 CDK4 MDM2
9 retinoblastoma 28.8 CDK4 MDM2 RB1
10 liposarcoma 28.4 CDK4 DES MDM2 RB1 VIM
11 ovarian fibrothecoma 10.4 ACTC1 DES
12 fibroblastic rheumatism 10.4 ACTC1 DES
13 skin glomus tumor 10.3 DES VIM
14 pulmonary vein stenosis 10.3 ACTC1 DES
15 infantile digital fibromatosis 10.3 DES VIM
16 cystic nephroma 10.3 ACTC1 DES
17 lymphangiomatosis 10.3 DES VIM
18 primitive neuroectodermal tumor of the cervix uteri 10.3 DES VIM
19 epulis 10.3 DES VIM
20 biphasic synovial sarcoma 10.3 DES VIM
21 lymphangiectasis 10.3 ACTC1 VIM
22 glomangiomyoma 10.3 ACTC1 VIM
23 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
24 syringoma 10.3 DES VIM
25 non-langerhans-cell histiocytosis 10.3 ACTC1 DES
26 juvenile xanthogranuloma 10.3 DES VIM
27 adenofibroma 10.3 ACTC1 VIM
28 mesenchymal chondrosarcoma 10.3 DES VIM
29 extraskeletal ewing sarcoma 10.3 DES VIM
30 angiocentric glioma 10.3 ACTC1 VIM
31 bilateral retinoblastoma 10.3 DES RB1
32 granular cell tumor 10.2 DES VIM
33 spiradenoma 10.2 ACTC1 VIM
34 congenital epulis 10.2 DES VIM
35 benign mesothelioma 10.2 DES VIM
36 angiomyolipoma 10.2 ACTC1 DES
37 dendritic cell tumor 10.2 ACTC1 VIM
38 familial isolated dilated cardiomyopathy 10.2 ACTC1 DES
39 granulosa cell tumor of the ovary 10.2 ACTC1 VIM
40 mesenchymoma 10.2 DES MDM2
41 polymorphous low-grade adenocarcinoma 10.2 ACTC1 VIM
42 myoepithelioma 10.2 ACTC1 VIM
43 chordoma 10.2 DES VIM
44 retroperitoneal fibrosis 10.1 MDM2 VIM
45 neurilemmoma 10.1 DES VIM
46 anaplastic ependymoma 10.1 MDM2 VIM
47 uterine sarcoma 10.1 DES MDM2
48 angiolipoma 10.1 ACTC1 DES VIM
49 cutaneous leiomyosarcoma 10.1 ACTC1 DES VIM
50 parachordoma 10.1 ACTC1 DES VIM

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to Spindle Cell Lipoma

Symptoms & Phenotypes for Spindle Cell Lipoma

MGI Mouse Phenotypes related to Spindle Cell Lipoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 DES FOXO1 VIM ACTC1 MDM2 CDK4
2 cellular MP:0005384 9.98 RB1 DES FOXO1 VIM ACTC1 MDM2
3 behavior/neurological MP:0005386 9.95 VIM RB1 DES FOXO1 MDM2 CDK4
4 homeostasis/metabolism MP:0005376 9.91 RB1 DES FOXO1 VIM ACTC1 MDM2
5 mortality/aging MP:0010768 9.87 VIM RB1 DES FOXO1 ACTC1 MDM2
6 embryo MP:0005380 9.8 VIM RB1 FOXO1 MDM2 CDK4
7 muscle MP:0005369 9.8 DES FOXO1 VIM ACTC1 MDM2 CDK4
8 neoplasm MP:0002006 9.46 RB1 FOXO1 MDM2 CDK4
9 normal MP:0002873 9.35 RB1 FOXO1 ACTC1 MDM2 CDK4
10 reproductive system MP:0005389 9.02 VIM RB1 FOXO1 MDM2 CDK4

Drugs & Therapeutics for Spindle Cell Lipoma

Search Clinical Trials , NIH Clinical Center for Spindle Cell Lipoma

Genetic Tests for Spindle Cell Lipoma

Anatomical Context for Spindle Cell Lipoma

MalaCards organs/tissues related to Spindle Cell Lipoma:

38
Tongue, Skin, Adipocyte, Bone

Publications for Spindle Cell Lipoma

Articles related to Spindle Cell Lipoma:

(show top 50) (show all 168)
# Title Authors Year
1
Cytopathological Diagnosis and Differential Diagnoses of Facial Spindle Cell Lipoma. ( 29403177 )
2018
2
Intrasynovial spindle cell lipoma of the deep flexor of the middle finger causing intermittent carpal tunnel syndrome-case report and review of the literature. ( 29429014 )
2018
3
Cytohistological Features of Spindle Cell Lipoma- A Case Report with Differential Diagnosis. ( 28384874 )
2017
4
Anisometric cell lipoma: Insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant ("fat-only") spindle cell lipoma. ( 28807343 )
2017
5
Molecular Signature of Tumors with Monoallelic 13q14 Deletion: a Case Series of Spindle Cell Lipoma and Genetically-Related Tumors Demonstrating a Link Between FOXO1 Status and p38 MAPK Pathway. ( 28887603 )
2017
6
Spindle Cell Lipoma in Dogs. ( 28494701 )
2017
7
Cytogenetic Analysis of a Pseudoangiomatous Pleomorphic/Spindle Cell Lipoma. ( 28476785 )
2017
8
Spindle cell lipoma with prominent Verocay bodies: A potential diagnostic pitfall. ( 28139026 )
2017
9
Intraosseous spindle cell lipoma of the mandible: case report. ( 28735633 )
2017
10
Pseudoangiomatous variant of spindle cell lipoma: Report of a rare case. ( 27510682 )
2016
11
Pseudoangiomatous Spindle Cell Lipoma: a distinct subtype of spindle cell lipoma. ( 27982506 )
2016
12
Low-Fat Plexiform Spindle Cell Lipoma With Prominent Myxoid Stroma: An Unusual Oral Presentation and Immunohistochemical Analysis. ( 28045832 )
2016
13
S-100 protein expressing spindle cells in spindle cell lipoma: a diagnostic pitfall. ( 27444171 )
2016
14
Dermal plexiform spindle cell lipoma. ( 27833986 )
2016
15
Spindle Cell Lipoma in an End-Stage Renal Allograft: Case Report. ( 27932168 )
2016
16
Acute dyspnea caused by a giant spindle cell lipoma of the larynx. ( 26438102 )
2015
17
"Low-Fat" Pseudoangiomatous Spindle Cell Lipoma: A Rare Variant With Loss of 13q14 Region. ( 25839893 )
2015
18
Spindle Cell Lipoma of the Neck: Review of the Literature and Case Report. ( 26893975 )
2015
19
Folliculosebaceous Cystic Hamartoma With Spindle Cell Lipoma-Like Stromal Features. ( 26588344 )
2015
20
Management of a Nasal Spindle Cell Lipoma: Diagnostic and Therapeutic Considerations. ( 26517318 )
2015
21
"Low Fat" Spindle Cell Lipoma of the Eyelid: A Diagnostic Challenge. ( 26017060 )
2015
22
Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature. ( 26045856 )
2015
23
Spindle cell lipoma of the tongue. ( 25682756 )
2015
24
Intramuscular spindle cell lipoma of the deltoid: a case report. ( 25880875 )
2015
25
Letter to the Editor: Re: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case. Response to Laliotis et al. ( 26017887 )
2015
26
Rare occurrence of lip spindle cell lipoma. ( 25815220 )
2015
27
Diagnostically challenging case of low-fat spindle cell lipoma. ( 26053070 )
2015
28
Spindle cell lipoma of the soft palate. ( 25878917 )
2015
29
Spindle Cell Lipoma Occurring in the Buccal Mucosa: An Unusual Location of This Benign Lipomatous Neoplasm. ( 26491592 )
2015
30
Oral Spindle Cell Lipoma in a Rare Location: A Differential Diagnosis. ( 26615969 )
2015
31
Spindle cell lipoma with predominant nerve sheath tumor-like areas: A potential diagnostic pitfall on aspiration cytology. ( 26457887 )
2015
32
Imaging characteristics of spindle cell lipoma and its variants. ( 24554024 )
2014
33
Spindle cell lipoma adherent to the digital nerve in the palm. ( 25414563 )
2014
34
Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. ( 24659226 )
2014
35
MR imaging features of spindle cell lipoma. ( 24240205 )
2014
36
Spindle Cell Lipoma of the Conjunctiva. ( 24911538 )
2014
37
Spindle Cell Lipoma of the Tongue: A Clinicopathologic Study of 8 Cases and Review of the Literature. ( 25319950 )
2014
38
A rare case of spindle cell lipoma of broad ligament presenting as a pelvic mass. ( 25422813 )
2014
39
Re: co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma. Report of a case. ( 25119179 )
2014
40
RE: "Fat-free" spindle cell lipoma in retropharynx. ( 24843246 )
2014
41
Dendritic fibromyxolipoma: a variant of spindle cell lipoma with extensive myxoid change, with cytogenetic evidence. ( 25047505 )
2014
42
Spindle cell lipoma of the mandibular mucogingival junction: a case report of unusual oral neoplasm. ( 24556953 )
2014
43
Spindle Cell Lipoma of the Orbit. ( 24819207 )
2014
44
Re: Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: Report of a case Ivan Chernev, Shane Mctighe, Dirk P. Stanley. ( 25372424 )
2014
45
Spindle cell lipoma of the tongue: A case report of unusual occurrence. ( 23798855 )
2013
46
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. ( 23851787 )
2013
47
Fine needle aspiration biopsy of intraparotid spindle cell lipoma: a case report. ( 22021087 )
2013
48
Subungual spindle cell lipoma. ( 22171806 )
2013
49
Spindle cell lipoma. ( 23946512 )
2013
50
Spindle cell lipoma masquerading as lipomatous pleomorphic adenoma: A diagnostic dilemma on fine needle aspiration cytology. ( 23661944 )
2013

Variations for Spindle Cell Lipoma

Expression for Spindle Cell Lipoma

Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for Spindle Cell Lipoma

Pathways related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CDK4 FOXO1 MDM2 RB1
2
Show member pathways
12.68 CDK4 FOXO1 MDM2 RB1
3 12.53 CDK4 FOXO1 MDM2 RB1
4
Show member pathways
12.44 CDK4 MDM2 RB1
5
Show member pathways
12.34 CDK4 MDM2 RB1
6
Show member pathways
12.34 CDK4 MDM2 RB1
7 12.3 ACTC1 DES VIM
8 12.2 CDK4 RB1 VIM
9
Show member pathways
12.19 CDK4 DES RB1
10 12.14 CDK4 MDM2 RB1 VIM
11
Show member pathways
12.13 CDK4 MDM2 RB1
12 12.12 CDK4 MDM2 RB1
13 12.06 MDM2 RB1 VIM
14 12.05 CDK4 MDM2 RB1
15
Show member pathways
11.98 CDK4 MDM2 RB1
16
Show member pathways
11.88 CDK4 MDM2 RB1
17
Show member pathways
11.81 CDK4 FOXO1 MDM2 RB1
18 11.75 CDK4 RB1 VIM
19 11.66 CDK4 FOXO1 MDM2 RB1
20 11.61 FOXO1 MDM2 RB1
21
Show member pathways
11.6 CDK4 RB1
22 11.58 CDK4 MDM2 RB1
23 11.47 CDK4 MDM2 RB1
24 11.44 ACTC1 DES VIM
25 11.44 CDK4 FOXO1 MDM2 RB1
26 11.41 MDM2 RB1
27 11.39 FOXO1 MDM2
28 11.35 FOXO1 MDM2
29
Show member pathways
11.29 DES VIM
30 11.27 CDK4 MDM2
31 11.19 CDK4 RB1
32 11.11 CDK4 MDM2
33 11.1 CDK4 MDM2 RB1
34 10.97 CDK4 FOXO1 MDM2 RB1
35 10.89 MDM2 RB1

GO Terms for Spindle Cell Lipoma

Biological processes related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 ACTC1 MDM2 VIM
2 response to drug GO:0042493 9.54 ACTC1 CDK4 MDM2
3 cellular response to hydrogen peroxide GO:0070301 9.46 FOXO1 MDM2
4 negative regulation of neuron projection development GO:0010977 9.43 MDM2 VIM
5 blood vessel development GO:0001568 9.4 FOXO1 MDM2
6 protein kinase B signaling GO:0043491 9.32 FOXO1 MDM2
7 positive regulation of cell cycle GO:0045787 9.26 CDK4 MDM2
8 negative regulation of cell cycle arrest GO:0071157 9.16 CDK4 MDM2
9 intermediate filament organization GO:0045109 8.96 DES VIM
10 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Spindle Cell Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.46 DES MDM2 RB1 VIM
2 scaffold protein binding GO:0097110 9.26 MDM2 VIM
3 ubiquitin protein ligase binding GO:0031625 9.13 FOXO1 MDM2 RB1
4 disordered domain specific binding GO:0097718 8.62 MDM2 RB1

Sources for Spindle Cell Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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