MCID: SPN006
MIFTS: 43

Spindle Cell Lipoma malady

Summaries for Spindle Cell Lipoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lipoma that is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men.

MalaCards: Spindle Cell Lipoma is related to lipoma and liposarcoma. An important gene associated with Spindle Cell Lipoma is DES (desmin), and among its related pathways are Cell Cycle and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds glycogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and bone, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:63 Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the... more...

Aliases & Classifications for Spindle Cell Lipoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

spindle cell lipoma 8 60


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Disease Ontology8 DOID:10184
SNOMED-CT56 404058008, 27313007
NCIt39 C4254

Related Diseases for Spindle Cell Lipoma

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17GeneCards, 18GeneDecks
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Diseases related to Spindle Cell Lipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1lipoma31.7CD34, CDK4, DES, MDM2, S100A1
2liposarcoma30.5CD34, CDK4, DES, RB1, MDM2, VIM
3dermatofibrosarcoma30.4MDM2
4adenoma30.2S100A1, RB1, CDK4, ACTC1
5pleomorphic adenoma30.2VIM, S100A1, MDM2, DES, ACTC1
6fibrosarcoma30.2VIM, MDM2, DES, CD34, ACTC1
7breast lipoma10.6
8pleomorphic lipoma10.4
9spindle cell liposarcoma10.4
10breast myofibroblastoma10.3
11lipoma of spermatic cord10.3
12atypical lipomatous tumor10.3
13infiltrating lipoma10.1
14mediastinum liposarcoma10.1
15myositis ossificans10.1
16skin lipoma10.1
17cervicitis10.1
18myositis10.1
19cerebral primitive neuroectodermal tumor10.0CD99
20peripheral primitive neuroectodermal tumor10.0CD99
21syringoma10.0S100A1
22infantile myofibromatosis10.0DES
23hepatitis10.0CD99
24lymphangioleiomyomatosis10.0DES
25psoriasis10.0S100A1
26hepatitis c10.0CD99
27fasciitis10.0ACTC1
28rheumatoid arthritis10.0S100A1
29paraganglioma10.0S100A1
30gliosarcoma10.0CDK4
31cutaneous fibrous histiocytoma10.0CD34
32malignant fibroxanthoma10.0CD34
33neurilemmoma10.0CD34
34acute leukemia10.0CD34
35oxyphilic adenoma10.0S100A1
36kaposi's sarcoma10.0CD34
37vascular cancer10.0CD34
38myelodysplastic syndromes10.0CD34
39giant cell glioblastoma10.0MDM2
40eye disease10.0MDM2
41epidermolysis bullosa simplex10.0DES
42desmoid tumor10.0DES, ACTC1
43teratoma10.0ACTC1, CD99
44hemangioma10.0ACTC1, CD34
45stomach cancer10.0CD34, CD99
46adenosarcoma10.0DES, ACTC1
47hemangioendothelioma10.0CD34
48pyogenic granuloma10.0CD34, ACTC1
49mucoepidermoid carcinoma10.0S100A1, ACTC1
50anaplastic oligodendroglioma10.0CDK4, MDM2

Graphical network of the top 20 diseases related to Spindle Cell Lipoma:



Diseases related to spindle cell lipoma

Clinical Features for Spindle Cell Lipoma

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Drugs & Therapeutics for Spindle Cell Lipoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Spindle Cell Lipoma

Drug clinical trials:

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Search NIH Clinical Center for Spindle Cell Lipoma

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Genetic Tests for Spindle Cell Lipoma

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Anatomical Context for Spindle Cell Lipoma

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32MalaCards
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MalaCards organs/tissues related to Spindle Cell Lipoma:

32
Breast, Tongue, Bone, Skin

Animal Models for Spindle Cell Lipoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Spindle Cell Lipoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9ACTC1, CDK4, RB1, MDM2
2MP:00053868.1CDK4, DES, RB1, MDM2, S100A1, VIM
3MP:00053857.4VIM, S100A1, MDM2, RB1, DES, CDK4

Publications for Spindle Cell Lipoma

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50PubMed
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Articles related to Spindle Cell Lipoma:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Co-existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma:report of a case. (24166610)
2013
2
Transoral robotic surgery for huge spindle cell lipoma of the hypopharynx. (23851787)
2013
3
Spindle cell lipoma. (23946512)
2013
4
Spindle cell lipoma masquerading as lipomatous pleomorphic adenoma: A diagnostic dilemma on fine needle aspiration cytology. (23661944)
2013
5
Dysphagia caused by spindle cell lipoma of hypopharynx: presentation of clinical case and literature review. (23326743)
2012
6
Focal breast uptake of 99mTc-sestamibi in a man with spindle cell lipoma. (22415820)
2012
7
Spindle cell lipoma of the hypopharynx. (21850199)
2011
8
Spindle cell lipoma of the orbit: a case report of an unusual orbital pathology. (20827617)
2010
9
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (20559119)
2010
10
Infiltrating intramuscular spindle cell lipoma of the face. (19187113)
2009
11
Spindle-cell lipoma. (19623524)
2009
12
Spindle cell lipoma of the esophagus. (19195907)
2009
13
Spindle cell lipoma of the vestibule of the nose. (18656742)
2008
14
CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking. (17497167)
2007
15
Giant spindle cell lipoma of the posterior neck. (17903161)
2007
16
Spindle cell lipoma: an uncommon tumour with distinctive morphology. (17397499)
2007
17
Buffalo hump: spindle cell lipoma in posterior part of the neck. (17214682)
2007
18
Spindle cell lipoma of the floor of the mouth. A case report. (16878055)
2006
19
Pathology quiz case 2. Spindle cell lipoma. (16490884)
2006
20
Massive spindle cell lipoma. (16399199)
2006
21
Extramammary myofibroblastoma is genetically related to spindle cell lipoma. (16715228)
2006
22
Spindle cell lipoma of the floor of the mouth: report of a case. (15917181)
2005
23
Pseudoangiomatous spindle cell lipoma with "true" angiomatous features. (16012844)
2005
24
Spindle cell lipoma in an intramuscular lipoma. (15363044)
2004
25
Dermal spindle cell lipoma of the posterior neck: CT and MR findings. (15018196)
2003
26
Imaging characteristics of spindle cell lipoma. (14573414)
2003
27
Intramuscular dendritic fibromyxolipoma: myxoid variant of spindle cell lipoma? (12675771)
2003
28
Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. (11889594)
2002
29
Spindle cell lipoma with extramedullary haematopoiesis. (11493343)
2001
30
Spindle cell lipoma of the female genital tract. A report of two cases. (11547655)
2001
31
Spindle cell lipoma of the parapharyngeal space: first report of a case. (11338650)
2001
32
Pleomorphic lipoma with pseudopapillary structures: a pleomorphic counterpart of pseudoangiomatous spindle cell lipoma. (10792493)
2000
33
Spindle cell lipoma of the scalp: a case report and review. (9935099)
1999
34
Spindle cell lipoma of the oral cavity: report of a case. (10319842)
1999
35
Spindle cell lipoma of the breast. (10503279)
1999
36
Angiomyofibroblastomalike tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. (9422311)
1998
37
Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. (9199640)
1997
38
Fibrohistiocytic differentiation in subcutaneous fatty tumors. Study of spindle cell, pleomorphic, myxoid, and atypical lipoma and dedifferentiated liposarcoma cases composed in part of CD34+ fibroblasts and FXIIIa+ histiocytes. (9331894)
1997
39
Spindle cell lipoma of the breast. A case report. (8995461)
1996
40
Spindle-cell lipoma of the skin. (8599462)
1995
41
Spindle cell lipoma in a 14-month-old girl. (8583335)
1995
42
Spindle cell lipoma of the oral cavity. (8627104)
1995
43
Intraoral spindle-cell lipoma: report of a case and literature review. (8572549)
1995
44
Dermal spindle cell lipoma: plexiform and nodular variants. (8838333)
1995
45
Spindle cell lipoma--a pseudoangiomatous variant. (8835273)
1995
46
Spindle cell lipoma--a pseudoangiomatous variant. (8063285)
1994
47
Spindle cell lipoma of the oral cavity: report of a case. (8046661)
1994
48
Oral spindle cell lipoma. Report of a case. (2507669)
1989
49
Large intramuscular spindle-cell lipoma. With review of the literature. A case report. (3285867)
1988
50
Spindle cell lipoma. (1192370)
1975

Genetic Variations for Spindle Cell Lipoma

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Expression for genes affiliated with Spindle Cell Lipoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Spindle Cell Lipoma

Search GEO for disease gene expression data for Spindle Cell Lipoma.

Pathways for genes affiliated with Spindle Cell Lipoma

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 55SinoBiological
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Pathways related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0UBE2D1
29.7RB1, MDM2
3
Hide members
9.7RB1, MDM2
49.5UBE2D1, RB1
5
Hide members
9.4VIM, DES, ACTC1
69.4ACTC1, DES, VIM
7
Hide members
9.3CDK4, RB1, MDM2
8
Transcription P53 signaling pathway
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9.3CDK4, RB1, MDM2
9
Hide members
9.3CDK4, RB1, MDM2
10
Hide members
9.3CDK4, RB1, MDM2
11
Hide members
9.3CDK4, RB1, MDM2
12
Hide members
9.3CDK4, RB1, MDM2
139.3MDM2, RB1, CDK4
14
Hide members
9.3MDM2, RB1, CDK4
15
Hide members
9.3MDM2, RB1, CDK4
169.3MDM2, RB1, CDK4
17
Hide members
9.3MDM2, RB1, CDK4
189.3MDM2, RB1, CDK4
199.3CDK4, RB1, VIM
209.2RB1, MDM2, VIM
21
Hide members
8.6VIM, MDM2, RB1, DES, CDK4
22
Hide members
8.4CDK4, RB1, MDM2, UBE2D1, VIM

Compounds for genes affiliated with Spindle Cell Lipoma

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1glycogen44 2410.9MDM2, ACTC1, CDK4
2orcein449.8ACTC1, DES, VIM
3s 100449.8DES, ACTC1, VIM
4benzo(a)pyrene449.7RB1, CDK4, MDM2
5flavopiridol44 1110.7CDK4, MDM2, RB1
6dexamethasone44 49 28 1112.6RB1, CDK4, MDM2
7paclitaxel44 49 1111.6CDK4, RB1, MDM2
8carboplatin44 49 1111.6CDK4, RB1, MDM2
9toluidine449.6VIM, S100A1, DES
10n-(4-hydroxyphenyl)retinamide449.6RB1, CDK4, VIM
112-methoxyethanol449.6S100A1, ACTC1, VIM
12progestin449.6DES, CDK4, VIM
13gefitinib44 49 1111.5CDK4, MDM2, VIM
14actomyosin449.5S100A1, VIM, ACTC1
15adpribose449.4CDK4, RB1, MDM2, DES
16formaldehyde44 2410.4ACTC1, DES, RB1, VIM
17bromodeoxyuridine449.3RB1, VIM, DES, CDK4
18adriamycin449.3MDM2, RB1, VIM, DES
19roscovitine449.3CDK4, VIM, MDM2, RB1
20mucicarmine449.3ACTC1, VIM, DES, S100A1
21b 723449.3ACTC1, S100A1, VIM, DES
22thymidylate449.3VIM, CDK4, RB1, MDM2
23vincristine44 49 1111.2RB1, MDM2, VIM
24rapamycin449.2CDK4, RB1, MDM2, VIM
25p002449.1MDM2, DES, RB1
26actinomycin d449.1DES, RB1, MDM2, VIM
27proline449.1VIM, DES, CDK4, MDM2
28steroid449.0DES, ACTC1, CDK4, MDM2, RB1
29silver449.0CD34, DES, S100A1
30reticulin449.0VIM, DES, CD34, ACTC1
31genistein44 28 59 2 11 2414.0RB1, MDM2, CDK4, VIM
32doxorubicin44 49 1111.0CDK4, VIM, DES, MDM2, RB1
33estradiol44 11 2411.0VIM, DES, RB1, CDK4, MDM2
34lysine448.9DES, RB1, MDM2, VIM
35cyclic amp44 249.9MDM2, CDK4, DES, RB1, VIM
36biotin44 11 2410.9RB1, ACTC1, S100A1, VIM, DES
37nitric oxide44 11 2410.7DES, S100A1, CDK4, MDM2, RB1
38testosterone44 59 11 2411.7MDM2, CDK4, ACTC1, DES, VIM, RB1
39oxygen44 249.6DES, CDK4, MDM2, ACTC1, RB1
40thymidine44 249.6DES, CDK4, RB1, CD34, MDM2
4112-o-tetradecanoylphorbol 13-acetate448.5CD34, VIM, RB1, DES, CDK4
42hematoxylin448.5VIM, S100A1, DES, CD34, ACTC1
43agar448.5CDK4, RB1, VIM, MDM2, CD34
44cysteine448.4S100A1, RB1, DES, CDK4, VIM, MDM2
45iron44 249.1MDM2, S100A1, ACTC1, CDK4, VIM, UBE2D1
46tyrosine447.7ACTC1, S100A1, MDM2, RB1, CDK4, CD34
47retinoic acid44 248.7VIM, S100A1, RB1, CDK4, CD34, DES
48progesterone44 59 28 11 2411.4VIM, DES, ACTC1, CDK4, MDM2, S100A1
49vegf447.3VIM, ACTC1, CD34, CD99, RB1, CDK4
50paraffin446.8CDK4, ACTC1, S100A1, CD34, CD99, DES

GO Terms for genes affiliated with Spindle Cell Lipoma

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16Gene Ontology
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Cellular components related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.2ACTC1, CDK4, DES, MDM2, UBE2D1, VIM

Biological processes related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of heart contractionGO:0080169.7DES, S100A1
2muscle filament slidingGO:0300499.1ACTC1, DES, VIM

Molecular functions related to Spindle Cell Lipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.6MDM2, VIM
2identical protein bindingGO:0428028.1DES, RB1, MDM2, S100A1, VIM

Products for genes affiliated with Spindle Cell Lipoma

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Sources for Spindle Cell Lipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet